NHLRC1 Gene
protein-coding GIFtS: 52
GCID: GC06M018065
|
|
NHL repeat containing 1
| |
Aliases
for NHLRC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NHL Repeat Containing 11 2 | | Malin3 | | EPM2B1 2 3 5 | | MALIN2 | | BA204B7.21 | | E3 Ubiquitin-Protein Ligase NHLRC12 | | NHL Repeat-Containing Protein 12 3 | | EC 6.3.2.-3 | | EPM2A2 5 | | Malin3 |
Export aliases for NHLRC1 gene to outside databasesPrevious GC identifers: GC00U913226 GC06U900282 GC06M018228 GC06M018120 |
Summaries
for NHLRC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NHLRC1:
The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encodedprotein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known asprogressive myoclonic epilepsy type 2 (EPM2).(provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: NHLC1_HUMAN, Q6VVB1Function: E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity ofmisfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). UbiquitinatesPPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradationdecreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them forproteasome-dependent degradation
Gene Wiki entry for NHLRC1
|
Genomic Views
for NHLRC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NHLRC1 gene promoter:
Max1 Elk-1 AML1a p53 Bach2 YY1 HEN1 HOXA5 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for NHLRC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHLRC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.3 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3NHLRC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M018065: view genomic region
(about GC identifiers)
Start:
|
18,120,718 bp from pter |
End:
|
18,122,851 bp from pter |
Size:
|
2,134 bases |
Orientation:
|
minus strand |
|
Proteins
for NHLRC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NHLC1_HUMAN, Q6VVB1 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase NHLRC1 Size: 395 amino acids; 42293 Da
Subunit: Interacts with AGL. Interacts (via the NHL repeats) with EPM2A/laforin. Forms a complex with EPM2A/laforin andHSP70
Subcellular location: Endoplasmic reticulum. Nucleus. Note=Localizes at the endoplasmic reticulum and, to a lesserextent, in the nucleus
Secondary accessions: Q3SYB1 Q5VUK7 Q6IMH1Explore the universe of human proteins at neXtProt for NHLRC1: NX_Q6VVB1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6VVB1
NHLRC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940988.2
ENSEMBL proteins: ENSP00000345464
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NHLRC1 for ontologies About GeneDecksing
NHLRC1 Antibody Products:
Assay Products for NHLRC1: |
Protein
Domains /
Families
for NHLRC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NHLRC1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6VVB1ProtoNet protein and cluster: Q6VVB1 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: NHLC1_HUMAN, Q6VVB1Domain: The RING domain is essential for ubiquitin E3 ligase activitySimilarity: Contains 6 NHL repeatsSimilarity: Contains 1 RING-type zinc finger |
Function
for NHLRC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NHLC1_HUMAN, Q6VVB1Function: E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity ofmisfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). UbiquitinatesPPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradationdecreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them forproteasome-dependent degradationEnzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHLRC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHLRC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NHLRC1 (NM_198586) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHLRC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLRC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLRC1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NHLRC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NHLRC1:
Animal Models:
Mouse knock-outs for NHLRC1: Nhlrc1tm1.2Geno Nhlrc1tm1(KOMP)Vlcg Nhlrc1tm1Bmin
9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Nhlrc1):
NHLRC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NHLRC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for NHLRC1):
UniProtKB/Swiss-Prot: NHLC1_HUMAN, Q6VVB1Pathway: Protein modification; protein ubiquitination
NHLRC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NHLRC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/15 Interacting proteins for NHLRC1 (Q6VVB12, 3 ENSP000003454644) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
NHLRC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NHLRC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NHLRC1 for compounds About GeneDecksing
 Browse Tocris compounds for NHLRC1
1 Novoseek chemical compound relationship for NHLRC1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glycogen |
56 |
17 |
18070875 (4), 19529779 (2), 18033035 (1) |
Search CenterWatch for drugs/clinical trials and news about NHLRC1 / NHLC1
|
Transcripts
for NHLRC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NHLRC1 gene: NM_198586.2 Unigene Cluster for NHLRC1: NHL repeat containing 1 Hs.348351 [show with all ESTs]Unigene Representative Sequence: NM_1985861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000340650(uc003ncl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHLRC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHLRC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NHLRC1 (NM_198586) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHLRC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLRC1 |
Additional cDNA sequence: AY324850.1 BC103888.1 BC103889.1 BC103890.1 1 DOTS entry: DT.99936660 13 AceView cDNA sequences: NM_198586 CA450023 AY324850 BK001510 BI711470 BU075743 AI275075 AA334003 AA868570 BI711752 BU075919 T78798 T78415
GeneLoc Exon Structure
|
Expression
for NHLRC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NHLRC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTTTCGCA
About this image
See NHLRC1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.348351
UniProtKB/Swiss-Prot: NHLC1_HUMAN, Q6VVB1Tissue specificity: Expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas
SABiosciences Expression via Pathway-Focused PCR Array including NHLRC1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHLRC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NHLRC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHLRC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHLRC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLRC1 |
Orthologs
for NHLRC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NHLRC1 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NHLRC11 |
NHL repeat containing 1 |
62.09(n)
53.63(a) |
|
428477 XM_426034.3 XP_426034.2 |
lizard
(Anolis carolinensis) |
Reptilia |
NHLRC16 |
-- |
55(a) |
1 ↔ 1 |
4(56947532-56948737) |
ENSEMBL Gene Tree for NHLRC1 (if available)
TreeFam Gene Tree for NHLRC1 (if available) |
Paralogs
for NHLRC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NHLRC1 gene
- TRIM32 TRIM712 TRIM452 TRIM562 TRIM22 TRIM322
NHLRC1 for paralogs About GeneDecksing
|
Genomic Variants
for NHLRC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NHLRC1 (18120718 - 18122851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NHLRC1: --
Human Gene Mutation Database (HGMD): NHLRC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHLRC1 |
|
Disorders
/ Diseases
for NHLRC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NHLRC1 for disorders About GeneDecksing
OMIM gene information: 608072
OMIM disorders: 254780
UniProtKB/Swiss-Prot: NHLC1_HUMAN, Q6VVB1
Defects in NHLRC1 are a cause of progressive myoclonic epilepsy type 2 (EPM2) [MIM:254780]; also known asLafora disease. EPM2 is an autosomal recessive and severe form of adolescent-onset progressive epilepsy. Typically, asseizures increase in frequency, cognitive function declines towards dementia, and affected individuals die usuallywithin 10 years after onset. EPM2 occurs worldwide, but it is particularly common in the mediterranean countries ofsouthern Europe and northern Africa, in southern India and in the Middle East. At the cellular level, it ischaracterized by accumulation of starch-like polyglucosans called Lafora bodies (LBs) that are most abundant in organswith the highest glucose metabolism: brain, heart, liver and skeletal muscle. Among other conditions involvingpolyglucosans, EPM2 is unique in that the inclusions are in neuronal dendrites but not axons and the formingpolyglucosan fibrils are associated with the endoplasmic reticulum
17  diseases for NHLRC1: About MalaCardslafora disease progressive myoclonus epilepsy myoclonus epilepsy neuroleptic malignant syndrome
myoclonus gaze palsy status epilepticus cerebellar ataxia
neurodegenerative disease dementia brain disease ataxia
seizures blindness neuropathy cardiomyopathy
hepatitis
3 diseases from the University of Copenhagen DISEASES database for NHLRC1:Progressive myoclonus epilepsy Neurodegenerative disease Neuroleptic malignant syndrome 6 Novoseek disease relationships for NHLRC1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lafora disease |
98.3 |
124 |
15781812 (8), 18311786 (7), 16950819 (6), 16021330 (5) (see all 29) |
| progressive myoclonus epilepsies |
96 |
18 |
18617530 (2), 15930137 (1), 19529779 (1), 16134145 (1) (see all 10) |
| neurodegenerative diseases |
50.4 |
3 |
15930137 (1), 19529779 (1) |
| neuroleptic malignant syndrome |
48.5 |
2 |
8904246 (1), 1970519 (1) |
| epilepsy |
39.6 |
6 |
15637270 (1), 12958597 (1), 16115820 (1) |
| dementia |
25.8 |
1 |
16115820 (1) |
GeneTests: NHLRC1
Progressive Myoclonus Epilepsy, Lafora Type
Human Genome Epidemiology (HuGE) Navigator: NHLRC1 (1 document)
Export disorders for NHLRC1 gene to outside databases
|
Publications
for NHLRC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NHLRC1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with NHLRC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in NHLRC1 cause progressive myoclonus epilepsy. (PubMed id 12958597)1, 2, 3, 9 Chan E.M.... Scherer S.W. (2003)
- Lafora disease in the Indian population: EPM2A and NHLRC1 gene mutations and their impact on subcellular localization of laforin and malin. (PubMed id 18311786)1, 2, 9 Singh S.... Ganesh S. (2008)
- Lafora disease due to EPM2B mutations: a clinical and genetic study. (PubMed id 15781812)1, 2, 9 Gomez-Abad C....Serratosa J.M. (2005)
- Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. (PubMed id 15930137)1, 2, 9 Gentry M.S....Dixon J.E. (2005)
- Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). (PubMed id 18070875)1, 2, 9 Worby C.A....Dixon J.E. (2008)
- The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system. (PubMed id 19036738)1, 2, 9 Garyali P....Ganesh S. (2009)
- A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. (PubMed id 17908927)1, 2 Cheng A....Saltiel A.R. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Novel NHLRC1 mutations and genotype-phenotype correlations in patients with Lafora's progressive myoclonic epilepsy. (PubMed id 16950819)1, 9 Singh S....Ganesh S. (2006)
|
External Searches for NHLRC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NHLRC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NHLRC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NHLRC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NHLRC1 | Pharmacogenomics, SNPs, Pathways | | The Lafora progressive myoclonus epilepsy mutation and polymorphism database | http://projects.tcag.ca/lafora/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NHLRC1 |
|
| | |
About This Section
| Patent Information for NHLRC1 gene:
Search GeneIP for patents involving NHLRC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NHLRC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHLRC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHLRC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NHLRC1 | | OriGene 3'-UTR Clone for NHLRC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHLRC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHLRC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NHLRC1 | | OriGene Custom Protein Services for NHLRC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NHLRC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHLRC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHLRC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHLRC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHLRC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHLRC1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NHLRC1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NHLRC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLRC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for NHLRC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLRC1 |
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