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NHLH2 Gene

protein-coding   GIFtS: 56
GCID: GC01M116378

Nescient Helix Loop Helix 2


(Previous symbol: HEN2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nescient Helix Loop Helix 21 2 3     bHLHa342 3
HEN21 2 3 5     NSCL22
Class A Basic Helix-Loop-Helix Protein 342 3     Helix-Loop-Helix Protein 22
HEN-22 3     BHLHA343
NSCL-22 3     KIAA04903

External Ids:    HGNC: 78181   Entrez Gene: 48082   Ensembl: ENSG000001775517   OMIM: 1623615   UniProtKB: Q025773   

Export aliases for NHLH2 gene to outside databases

Previous GC identifers: GC01M116792 GC01M115261 GC01M115527 GC01M115726 GC01M116091 GC01M116180 GC01M114236


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NHLH2 Gene:
NHLH2 (nescient helix loop helix 2) is a protein-coding gene. Diseases associated with NHLH2 include egg allergy, and hypogonadism. GO annotations related to this gene include RNA polymerase II activating transcription factor binding and protein dimerization activity. An important paralog of this gene is NHLH1.

UniProtKB/Swiss-Prot: HEN2_HUMAN, Q02577
Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly
within the developing nervous system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NHLH2 gene promoter:
         STAT3   AP-4   AP-2alpha   AP-2alphaA   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNHLH2 promoter sequence
   Search Chromatin IP Primers for NHLH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NHLH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12-p11   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p12-p11

NHLH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NHLH2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M116378:  view genomic region     (about GC identifiers)

Start:
116,378,998 bp from pter      End:
116,386,538 bp from pter
Size:
7,541 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HEN2_HUMAN, Q02577 (See protein sequence)
Recommended Name: Helix-loop-helix protein 2  
Size: 135 amino acids; 15018 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Secondary accessions: Q5T1P6

Explore the universe of human proteins at neXtProt for NHLH2: NX_Q02577

Explore proteomics data for NHLH2 at MOPED


See NHLH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001104531.1  NP_005590.1  

ENSEMBL proteins: 
 ENSP00000322087   ENSP00000358519   ENSP00000405062  

NHLH2 Human Recombinant Protein Products:

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OriGene Purified Protein for NHLH2
OriGene Protein Over-expression Lysate for NHLH2
OriGene MassSpec for NHLH2
OriGene Custom Protein Services for NHLH2
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Novus Biologicals NHLH2 Protein
Novus Biologicals NHLH2 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for NHLH2
Cloud-Clone Corp. Proteins for NHLH2

NHLH2 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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OriGene Custom Antibody Services for NHLH2
Novus Biologicals NHLH2 Antibodies
Abcam antibodies for NHLH2
Cloud-Clone Corp. Antibodies for NHLH2
Search ThermoFisher Antibodies for NHLH2
LSBio Antibodies in human, mouse, rat for NHLH2

NHLH2 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for NHLH2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for NHLH2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for NHLH2
Cloud-Clone Corp. CLIAs for NHLH2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
bHLH: Basic helix-loop-helix proteins

1 InterPro protein domain:
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q02577

ProtoNet protein and cluster: Q02577

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: HEN2_HUMAN, Q02577
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


NHLH2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HEN2_HUMAN, Q02577
Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly
within the developing nervous system

     Genatlas biochemistry entry for NHLH2:
nescient helix loop helix protein 2,coexpressed in neuroblastoma cell line with NHLH1

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001102RNA polymerase II activating transcription factor binding IPI16314316
GO:0003677DNA binding IEA--
GO:0005515protein binding IPI--
GO:0046983protein dimerization activity IEA--
     
NHLH2 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for NHLH2:
 Increased G2M DNA content  Large cells 

     12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nhlh2):
 adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland 
 growth/size/body  homeostasis/metabolism  integument  mortality/aging  nervous system 
 renal/urinary system  reproductive system 

NHLH2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Nhlh2tm1Irk for NHLH2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NHLH2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NHLH2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NHLH2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NHLH2

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat NHLH2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NHLH2 (see all 61):
hsa-miR-576-3p hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-3616-5p hsa-miR-301a hsa-miR-30d
SwitchGear 3'UTR luciferase reporter plasmidNHLH2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for NHLH2
Predesigned siRNA for gene silencing in human, mouse, rat NHLH2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for NHLH2

Clone
Products:
     
OriGene clones in human, mouse for NHLH2 (see all 9)
OriGene ORF clones in mouse, rat for NHLH2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): NHLH2 (NM_005599)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHLH2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for NHLH2
Browse ESI BIO Cell Lines and PureStem Progenitors for NHLH2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HEN2_HUMAN, Q02577: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005667transcription factor complex TAS16314316

NHLH2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NHLH2 About    
See pathways by source

SuperPathContained pathways About
1Transcription factors in neurogenesis
Transcription factors in neurogenesis



    Pathway & Disease-focused RT2 Profiler PCR Array including NHLH2: 
          T-Cell Anergy & Immune Tolerance in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for NHLH2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for NHLH2 (Q025771, 3 ENSP000003220874) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
LMO3Q8TAP43, ENSP000003466894I2D: score=1 STRING: ENSP00000346689
SIRT1Q96EB61, ENSP000002120154EBI-5378683,EBI-1802965 STRING: ENSP00000212015
TCF3ENSP000002629654STRING: ENSP00000262965
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0007417central nervous system development TAS1328219
GO:0007617mating behavior IEA--
GO:0030154cell differentiation IEA--
GO:0042698ovulation cycle IEA--

NHLH2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NHLH2 (HEN2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NHLH2 gene (2 alternative transcripts): 
NM_001111061.1  NM_005599.3  

Unigene Cluster for NHLH2:

Nescient helix loop helix 2
Hs.46296  [show with all ESTs]
Unigene Representative Sequence: M96740
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000320238(uc009wgz.3 uc001efy.3) ENST00000369506(uc021osf.1)
ENST00000429731
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NHLH2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NHLH2 (see all 61):
hsa-miR-576-3p hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-3616-5p hsa-miR-301a hsa-miR-30d
SwitchGear 3'UTR luciferase reporter plasmidNHLH2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NHLH2
Predesigned siRNA for gene silencing in human, mouse, rat NHLH2
Clone
Products:
     
OriGene clones in human, mouse for NHLH2 (see all 9)
OriGene ORF clones in mouse, rat for NHLH2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): NHLH2 (NM_005599)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHLH2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for NHLH2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NHLH2
  QuantiTect SYBR Green Assays in human, mouse, rat NHLH2
  QuantiFast Probe-based Assays in human, mouse, rat NHLH2

Additional mRNA sequence: 

AK307156.1 AK312849.1 BC096359.3 BC096360.1 M96740.1 

5 DOTS entries:

DT.91751519  DT.409829  DT.40131636  DT.97768438  DT.100735527 

6 AceView cDNA sequences:

NM_005599 AI216572 AA947913 AA975977 M96740 BE045427 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NHLH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATGGTGCGC
NHLH2 Expression
About this image


NHLH2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         nGnG Amacrine Cells Inner Nuclear Layer
         Retina
 
 Ovary (Reproductive System)
         Ovarian Somatic Cells Ovigerous Cord
 
 Neurons
         nGnG Amacrine Cells Inner Nuclear Layer
 
 Head Mesenchyme (Muscoskeletal System)
         Frontonasal Process
 
 Testis (Reproductive System)
NHLH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NHLH2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.46296
    Pathway & Disease-focused RT2 Profiler PCR Array including NHLH2: 
          T-Cell Anergy & Immune Tolerance in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for NHLH2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NHLH2
QuantiTect SYBR Green Assays in human, mouse, rat NHLH2
QuantiFast Probe-based Assays in human, mouse, rat NHLH2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NHLH2 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nhlh21 , 5 nescient helix loop helix 21, 5 91.85(n)1
97.78(a)1
  3 (44.30 cM)5
180721  NM_178777.31  NP_848892.11 
 1020101455 
chicken
(Gallus gallus)
Aves NHLH21 nescient helix loop helix 2 83.21(n)
85.71(a)
  395578  NM_204797.1  NP_990128.1 
lizard
(Anolis carolinensis)
Reptilia NHLH26
nescient helix loop helix 2
77(a)
1 ↔ 1
2(82971566-82971985)
African clawed frog
(Xenopus laevis)
Amphibia XHEN12 transcription factor XHEN1 77.06(n)    U94992.1 
zebrafish
(Danio rerio)
Actinopterygii nhlh21 nescient helix loop helix 2 70.31(n)
78.15(a)
  402968  NM_205669.1  NP_991232.1 
fruit fly
(Drosophila melanogaster)
Insecta HLH4C6
Helix loop helix protein 4C
44(a)
1 → many
X(4539160-4541447)
worm
(Caenorhabditis elegans)
Secernentea hlh-156
Protein HLH-15 (hlh-15) mRNA, complete cds
65(a)
1 → many
X(2412969-2413288) WBGene00001959


ENSEMBL Gene Tree for NHLH2 (if available)
TreeFam Gene Tree for NHLH2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NHLH2 gene
NHLH12  TWIST12  TWIST22  HAND22  TAL12  LYL12  TAL22  TCF152  
SCXB2  HAND12  SCXA2  
8 SIMAP similar genes for NHLH2 using alignment to 2 protein entries:     HEN2_HUMAN (see all proteins):
SCL    TAL2    PTF1A    TCF15    NHLH1    LYL1
HAND2    TWIST1

NHLH2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NHLH2 (see all 109)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1394843921,2
--116378623(+) AATAGC/TTATGT 2 -- ds50010--------
rs28115671,2
C,F--116378633(+) TGTTTT/CAGTGT 2 -- ds50013Minor allele frequency- C:0.09NA WA 122
rs1125862311,2
C,F--116378643(+) TAGGTC/TACTCC 2 -- ds50012Minor allele frequency- T:0.08CSA WA 120
rs776753121,2
C,F--116378833(+) ATCCAC/TGTCCA 2 -- ds50012Minor allele frequency- T:0.17CSA WA 120
rs1497447311,2
--116378916(+) CTAAGC/GAATTG 2 -- ds50010--------
rs1915411661,2
C--116379212(+) TTTAAA/C/GAGTTT 4 -- ut310--------
rs796685741,2
C,F--116379230(+) GAGAAC/TATGAA 2 -- ut311Minor allele frequency- T:0.13WA 118
rs109235751,2
C,F,H--116379302(+) TTTTTC/ATTTTT 2 -- ut31 trp34Minor allele frequency- A:0.02NS NA 506
rs1821818901,2
--116379356(+) AAACAC/TCACAC 2 -- ut310--------
rs1860954371,2
--116379371(+) AAAGAA/GGCTAC 2 -- ut310--------

HapMap Linkage Disequilibrium report for NHLH2 (116378998 - 116386538 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for NHLH2:    About this table    
Variant IDTypeSubtypePubMed ID
esv27976CNV Loss19812545
nsv508559CNV Loss20534489
nsv831115CNV Gain17160897

Human Gene Mutation Database (HGMD): NHLH2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NHLH2
DNA2.0 Custom Variant and Variant Library Synthesis for NHLH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 162361    OMIM disorders: --

7 diseases for NHLH2:    
About MalaCards
egg allergy    hypogonadism    neuroblastoma    obesity
rheumatoid arthritis    arthritis    neuronitis

1 disease from the University of Copenhagen DISEASES database for NHLH2:
Egg allergy

NHLH2 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for NHLH2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 2 17633478 (1), 15930276 (1)

Genetic Association Database (GAD): NHLH2
Human Genome Epidemiology (HuGE) Navigator: NHLH2 (2 documents)

Export disorders for NHLH2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NHLH2 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with NHLH2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. (PubMed id 1528853)1, 2, 3 Brown L.... Baer R. (Proc. Natl. Acad. Sci. U.S.A. 1992)
  2. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
  6. A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. (PubMed id 1328219)1, 2 Lipkowitz S....Kirsch I.R. (J. Biol. Chem. 1992)
  7. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (PubMed id 15930276)1, 9 Aoyama M....Nakagawara A. (Cancer Res. 2005)
  8. Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding. (PubMed id 23026212)1 Al Rayyan N....Good D.J. (Gene 2013)
  9. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (Mol. Cell. Biol. 2012)
  10. Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1. (PubMed id 21573214)1 Isogai E....Nakagawara A. (PLoS ONE 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4808 HGNC: 7818 AceView: NHLH2 Ensembl:ENSG00000177551 euGenes: HUgn4808
ECgene: NHLH2 H-InvDB: NHLH2

(According to HUGE)
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HUGE: KIAA0490

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NHLH2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NHLH2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NHLH2 gene:
Search GeneIP for patents involving NHLH2

GeneCards and IP:
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