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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NHLH2 Gene

protein-coding GIFtS: 55
GCID: GC01M116378

nescient helix loop helix 2

(Previous symbol: HEN2)

Explore 6 diseases affiliated with
NHLH2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nescient Helix Loop Helix 2¹ ² ³		HEN-2² ³
HEN2¹ ² ³ ⁵		NSCL-2² ³
BHLHa34¹		Helix-Loop-Helix Protein 2²
NSCL2¹ ²		BHLHA34³
Class A Basic Helix-Loop-Helix Protein 34² ³		KIAA0490³

External Ids:	HGNC: 7818¹	Entrez Gene: 4808²	Ensembl: ENSG00000177551⁷	OMIM: 162361⁵	UniProtKB: Q02577³

Export aliases for NHLH2 gene to outside databases

Previous GC identifers: GC01M116792 GC01M115261 GC01M115527 GC01M115726 GC01M116091 GC01M116180 GC01M114236

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HEN2_HUMAN, Q02577

Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly

within the developing nervous system

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NHLH2 gene promoter:
STAT3 AP-4 AP-2alpha AP-2alphaA GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NHLH2 promoter sequence

Search SABiosciences Chromatin IP Primers for NHLH2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHLH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12-p11 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p12-p11

NHLH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NHLH2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M116378: view genomic region (about GC identifiers)

Start:	116,378,998 bp from pter	End:	116,386,538 bp from pter
Size:	7,541 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HEN2_HUMAN, Q02577 (See protein sequence)

Recommended Name: Helix-loop-helix protein 2

Size: 135 amino acids; 15018 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q5T1P6

Explore the universe of human proteins at neXtProt for NHLH2: NX_Q02577

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q02577

NHLH2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001104531.1 NP_005590.1

ENSEMBL proteins:

ENSP00000322087 ENSP00000358519 ENSP00000405062

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NHLH2 OriGene Protein Over-expression Lysate (see all 2): NHLH2 OriGene Custom Protein Services for NHLH2
	GenScript Custom Purified and Recombinant Proteins Services for NHLH2
	Novus Biologicals NHLH2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NHLH2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005667	transcription factor complex	TAS	16314316

NHLH2 for ontologies About GeneDecksing

NHLH2 Antibody Products:

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	Uscn Antibodies for NHLH2
	Search ThermoFisher Antibodies for NHLH2

Assay Products for NHLH2:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for NHLH2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NHLH2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NHLH2 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry Q02577

ProtoNet protein and cluster: Q02577

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: HEN2_HUMAN, Q02577

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HEN2_HUMAN, Q02577

Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly

within the developing nervous system

Genatlas biochemistry entry for NHLH2:

nescient helix loop helix protein 2,coexpressed in neuroblastoma cell line with NHLH1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NHLH2
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate NHLH2 (see all 61):
		hsa-miR-576-3p hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-3616-5p hsa-miR-301a hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: NHLH2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHLH2 (see all 7) OriGene shRNA RFP: NHLH2 OriGene siRNA: NHLH2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHLH2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NHLH2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHLH2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHLH2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NHLH2 (NM_005599)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHLH2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NHLH2
		Search LifeMap BioReagents cell lines for NHLH2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001102	RNA polymerase II activating transcription factor binding	IPI	16314316
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0046983	protein dimerization activity	IEA	--

NHLH2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NHLH2:

Increased G2M DNA content

Large cells

Animal Models:
Mouse knock-out Nhlh2^tm1Irk for NHLH2
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nhlh2):

adipose tissue	behavior/neurological	cardiovascular system	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	integument	mortality/aging	nervous system
renal/urinary system	reproductive system

NHLH2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription factors in neurogenesis

Transcription factors in neurogenesis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NHLH2

Transcription factors in neurogenesis

NHLH2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NHLH2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for NHLH2 (Q02577^{1, 3} ENSP00000322087⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LMO3	Q8TAP4³, ENSP00000346689⁴	I2D: score=1 STRING: ENSP00000346689
SIRT1	Q96EB6¹, ENSP00000212015⁴	EBI-5378683,EBI-1802965 STRING: ENSP00000212015
TCF3	ENSP00000262965⁴	STRING: ENSP00000262965

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007417	central nervous system development	TAS	1328219
GO:0007617	mating behavior	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0042698	ovulation cycle	IEA	--

NHLH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NHLH2
Search CenterWatch for drugs/clinical trials and news about NHLH2 / HEN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NHLH2 gene (2 alternative transcripts):

NM_001111061.1 NM_005599.3

Unigene Cluster for NHLH2:

Nescient helix loop helix 2

Hs.46296 [show with all ESTs]

Unigene Representative Sequence: M96740

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000320238(uc009wgz.3 uc001efy.3) ENST00000369506(uc021osf.1)

ENST00000429731

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NHLH2
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate NHLH2 (see all 61):
		hsa-miR-576-3p hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-300 hsa-miR-3616-5p hsa-miR-301a hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: NHLH2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHLH2 (see all 7) OriGene shRNA RFP: NHLH2 OriGene siRNA: NHLH2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHLH2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHLH2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHLH2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NHLH2 (NM_005599)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHLH2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHLH2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NHLH2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHLH2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHLH2

Additional cDNA sequence:

AK307156.1 AK312849.1 BC096359.3 BC096360.1 M96740.1

5 DOTS entries:

DT.91751519 DT.409829 DT.40131636 DT.97768438 DT.100735527

6 AceView cDNA sequences:

AI216572 AA947913 NM_005599 AA975977 M96740 BE045427

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NHLH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGGTGCGC

About this image

NHLH2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Amacrine, Retina

Ovarian Somatic Cells

Ovary

Brain

Brain

Head Mesenchyme

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NHLH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NHLH2

SOURCE GeneReport for Unigene cluster: Hs.46296

SABiosciences Expression via Pathway-Focused PCR Array including NHLH2:

T-Cell Anergy & Immune Tolerance in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHLH2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NHLH2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHLH2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHLH2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NHLH2 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NHLH2¹	nescient helix loop helix 2	83.21(n) 85.71(a)		395578 NM_204797.1 NP_990128.1
lizard (Anolis carolinensis)	Reptilia	NHLH2⁶	--	77(a)	1 ↔ 1	2(82971566-82971985)
African clawed frog (Xenopus laevis)	Amphibia	XHEN1²	transcription factor XHEN1	77.06(n)		U94992.1
zebrafish (Danio rerio)	Actinopterygii	nhlh2¹	nescient helix loop helix 2	68.87(n) 74.38(a)		402968 NM_205669.1 NP_991232.1
fruit fly (Drosophila melanogaster)	Insecta	HLH4C⁶	Helix loop helix protein 4C	41(a)	1 → many	X(4539160-4541447)
worm (Caenorhabditis elegans)	Secernentea	hlh-15⁶	Helix Loop Helix family member (hlh-15)	57(a)	1 → many	X(2412962-2413281)

ENSEMBL Gene Tree for NHLH2 (if available)
TreeFam Gene Tree for NHLH2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NHLH2 gene

TCF24² NHLH1² TWIST1² TWIST2² TAL1² HAND2² TCF23² LYL1²

TAL2² TCF15² SCXB² TCF21² HAND1² MSC² SCXA²

11 SIMAP similar genes for NHLH2 using alignment to 2 protein entries: HEN2_HUMAN (see all proteins):

SCL TAL2 PTF1A TCF15 NHLH1 LYL1

HAND2 TWIST1 HAND1 SCXA SCXB

NHLH2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139484392^1,2		--	116378623(+)	`AATAGC/TTATGT`	2	--	ds500¹		0	--	--	--	--
rs2811567^1,2	C,	--	116378633(+)	`TGTTTT/CAGTGT`	2	--	ds500¹		3		NA WA	122
rs112586231^1,2		--	116378643(+)	`TAGGTC/TACTCC`	2	--	ds500¹		2		CSA WA	120
rs77675312^1,2		--	116378833(+)	`ATCCAC/TGTCCA`	2	--	ds500¹		2		CSA WA	120
rs149744731^1,2		--	116378916(+)	`CTAAGC/GAATTG`	2	--	ds500¹		0	--	--	--	--
rs191541166^1,2		--	116379212(+)	`TTTAAA/GAGTTT`	2	--	ut3¹		0	--	--	--	--
rs79668574^1,2	C,F,	--	116379230(+)	`GAGAAC/TATGAA`	2	--	ut3¹		1		WA	118
rs10923575^1,2	C,F,H,	--	116379302(+)	`TTTTTC/ATTTTT`	2	--	ut3¹ trp³		4		NS NA	506
rs182181890^1,2		--	116379356(+)	`AAACAC/TCACAC`	2	--	ut3¹		0	--	--	--	--
rs186095437^1,2		--	116379371(+)	`AAAGAA/GGCTAC`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NHLH2 (116378998 - 116386538 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NHLH2
3 CNVs: 64669 2322 3306

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHLH2

DNA2.0 Custom Variant and Variant Library Synthesis for NHLH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NHLH2 for disorders           About GeneDecksing

OMIM gene information: 162361    OMIM disorders: --

6 diseases for NHLH2:    About MalaCards

rheumatoid arthritis hypogonadism arthritis obesity

neuroblastoma neuronitis

1 Novoseek disease relationship for NHLH2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	17633478 (1), 15930276 (1)

Human Genome Epidemiology (HuGE) Navigator: NHLH2 (2 documents)

Export disorders for NHLH2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NHLH2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with NHLH2)

Utopia: connect your pdf to the dynamic
world of online information

HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. (PubMed id 1528853)^{1, 2, 3} Brown L.... Baer R. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (1997)
A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. (PubMed id 1328219)^{1, 2} Lipkowitz S....Kirsch I.R. (1992)
LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (PubMed id 15930276)^{1, 9} Aoyama M....Nakagawara A. (2005)
Two single nucleotide polymorphisms in the human nesci ent helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding. (PubMed id 23026212)¹ Al Rayyan N....Good D.J. (2013)
Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)¹ Teachenor R....Murre C. (2012)
Oncogenic LMO3 collaborates with HEN2 to enhance neur oblastoma cell growth through transactivation of Mash1. (PubMed id 21573214)¹ Isogai E....Nakagawara A. (2011)
Genetic variants at CD28, PRDM1 and CD2/CD58 are asso ciated with rheumatoid arthritis risk. (PubMed id 19898481)¹ Raychaudhuri S....Plenge R.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4808	HGNC: 7818	AceView: NHLH2	Ensembl:ENSG00000177551	euGenes: HUgn4808
ECgene: NHLH2	H-InvDB: NHLH2

(According to HUGE)
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HUGE: KIAA0490

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NHLH2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NHLH2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NHLH2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NHLH2 gene:
Search GeneIP for patents involving NHLH2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH2

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Search ThermoFisher Antibodies for NHLH2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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NHLH2 Gene

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for NHLH2 gene

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for NHLH2 gene

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for NHLH2 gene

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for NHLH2 gene

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for NHLH2 gene

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for NHLH2 gene

Expression
for NHLH2 gene

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for NHLH2 gene

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for NHLH2 gene

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for NHLH2 gene

Disorders / Diseases
for NHLH2 gene

Publications
for NHLH2 gene

Intellectual Property
for NHLH2 gene

Products
for NHLH2 gene