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Aliases for NHLH2 Gene

Aliases for NHLH2 Gene

  • Nescient Helix Loop Helix 2 2 3 4
  • HEN2 3 4 6
  • Class A Basic Helix-Loop-Helix Protein 34 3 4
  • BHLHa34 3 4
  • NSCL-2 3 4
  • HEN-2 3 4
  • Helix-Loop-Helix Protein 2 3
  • KIAA0490 4
  • NSCL2 3

External Ids for NHLH2 Gene

Previous Symbols for NHLH2 Gene

  • HEN2

Summaries for NHLH2 Gene

GeneCards Summary for NHLH2 Gene

NHLH2 (Nescient Helix Loop Helix 2) is a Protein Coding gene. Diseases associated with NHLH2 include egg allergy. GO annotations related to this gene include protein dimerization activity and RNA polymerase II activating transcription factor binding. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for NHLH2 Gene

  • May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLH2 Gene

Genomics for NHLH2 Gene

Genomic Location for NHLH2 Gene

115,836,377 bp from pter
115,843,917 bp from pter
7,541 bases
Minus strand

Genomic View for NHLH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NHLH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLH2 Gene

Regulatory Elements for NHLH2 Gene

Proteins for NHLH2 Gene

  • Protein details for NHLH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Helix-loop-helix protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5T1P6

    Protein attributes for NHLH2 Gene

    135 amino acids
    Molecular mass:
    15018 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein

neXtProt entry for NHLH2 Gene

Proteomics data for NHLH2 Gene at MOPED

Post-translational modifications for NHLH2 Gene

No Post-translational modifications

Other Protein References for NHLH2 Gene

No data available for DME Specific Peptides for NHLH2 Gene

Domains for NHLH2 Gene

Gene Families for NHLH2 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for NHLH2 Gene


  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q02577
genes like me logo Genes that share domains with NHLH2: view

Function for NHLH2 Gene

Molecular function for NHLH2 Gene

GENATLAS Biochemistry: nescient helix loop helix protein 2,coexpressed in neuroblastoma cell line with NHLH1
UniProtKB/Swiss-Prot Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system

Gene Ontology (GO) - Molecular Function for NHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 16314316
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22169038
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NHLH2: view
genes like me logo Genes that share phenotypes with NHLH2: view

Animal Models for NHLH2 Gene

MGI Knock Outs for NHLH2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NHLH2 Gene

Localization for NHLH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NHLH2 Gene

Subcellular locations from

Jensen Localization Image for NHLH2 Gene COMPARTMENTS Subcellular localization image for NHLH2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for NHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex TAS 16314316
genes like me logo Genes that share ontologies with NHLH2: view

Pathways for NHLH2 Gene

SuperPathways for NHLH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NHLH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007417 central nervous system development TAS 1328219
GO:0007617 mating behavior IEA --
GO:0030154 cell differentiation IEA --
GO:0042698 ovulation cycle IEA --
genes like me logo Genes that share ontologies with NHLH2: view

No data available for Pathways by source for NHLH2 Gene

Transcripts for NHLH2 Gene

mRNA/cDNA for NHLH2 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NHLH2 Gene

Nescient helix loop helix 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NHLH2 Gene

No ASD Table

Relevant External Links for NHLH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHLH2 Gene

mRNA expression in normal human tissues for NHLH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NHLH2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.5), Brain - Cerebellum (8.0), and Brain - Hypothalamus (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NHLH2 Gene

SOURCE GeneReport for Unigene cluster for NHLH2 Gene Hs.46296

genes like me logo Genes that share expressions with NHLH2: view

Orthologs for NHLH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NHLH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHLH2 36
  • 99.51 (n)
  • 100 (a)
NHLH2 37
  • 100 (a)
(Bos Taurus)
Mammalia NHLH2 36
  • 95.24 (n)
  • 96.99 (a)
NHLH2 37
  • 97 (a)
(Canis familiaris)
Mammalia NHLH2 36
  • 96.05 (n)
  • 97.78 (a)
NHLH2 37
  • 98 (a)
(Mus musculus)
Mammalia Nhlh2 36
  • 91.85 (n)
  • 97.78 (a)
Nhlh2 16
Nhlh2 37
  • 98 (a)
(Monodelphis domestica)
Mammalia NHLH2 37
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia NHLH2 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Nhlh2 36
  • 93.09 (n)
  • 97.04 (a)
(Gallus gallus)
Aves NHLH2 36
  • 83.21 (n)
  • 85.71 (a)
(Anolis carolinensis)
Reptilia NHLH2 37
  • 77 (a)
African clawed frog
(Xenopus laevis)
Amphibia XHEN1 36
(Danio rerio)
Actinopterygii nhlh2 36
  • 70.31 (n)
  • 78.15 (a)
nhlh2 37
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta HLH4C 37
  • 44 (a)
(Caenorhabditis elegans)
Secernentea hlh-15 37
  • 65 (a)
Species with no ortholog for NHLH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NHLH2 Gene

Gene Tree for NHLH2 (if available)
Gene Tree for NHLH2 (if available)

Paralogs for NHLH2 Gene

Paralogs for NHLH2 Gene

Selected SIMAP similar genes for NHLH2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NHLH2: view

Variants for NHLH2 Gene

Sequence variations from dbSNP and Humsavar for NHLH2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs883555 -- 115,839,697(+) CCTCC(A/G)CGACG intron-variant, utr-variant-5-prime
rs1109610 -- 115,839,333(-) CTCCC(G/T)CCGGG intron-variant
rs1418664 -- 115,841,469(-) GAATT(C/T)TTTGA upstream-variant-2KB
rs2797191 -- 115,839,890(-) AGCTC(A/C/T)CTGGG intron-variant, utr-variant-5-prime
rs2797208 -- 115,841,959(-) ACTGG(A/G)ACACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NHLH2 Gene

Variant ID Type Subtype PubMed ID
esv27976 CNV Loss 19812545
nsv831115 CNV Gain 17160897
nsv508559 CNV Loss 20534489

Relevant External Links for NHLH2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for NHLH2 Gene

(1) MalaCards Diseases for NHLH2 Gene

Search for NHLH2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NHLH2 Gene

(1) Novoseek inferred disease relationships for NHLH2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for NHLH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NHLH2: view

No data available for UniProtKB/Swiss-Prot for NHLH2 Gene

Publications for NHLH2 Gene

  1. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. (PMID: 1528853) Brown L. … Baer R. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  3. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (PMID: 15930276) Aoyama M. … Nakagawara A. (Cancer Res. 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for NHLH2 Gene

Sources for NHLH2 Gene

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