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Aliases for NHLH1 Gene

Aliases for NHLH1 Gene

  • Nescient Helix Loop Helix 1 2 3 4
  • HEN1 3 4 6
  • Class A Basic Helix-Loop-Helix Protein 35 3 4
  • BHLHa35 3 4
  • NSCL-1 3 4
  • HEN-1 3 4
  • Helix-Loop-Helix Protein 1 3
  • NSCL1 3
  • NSCL 3

External Ids for NHLH1 Gene

Previous HGNC Symbols for NHLH1 Gene

  • HEN1

Previous GeneCards Identifiers for NHLH1 Gene

  • GC01P158128
  • GC01P156069
  • GC01P157114
  • GC01P157553
  • GC01P157149
  • GC01P158603
  • GC01P160336
  • GC01P131693

Summaries for NHLH1 Gene

Entrez Gene Summary for NHLH1 Gene

  • The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]

GeneCards Summary for NHLH1 Gene

NHLH1 (Nescient Helix Loop Helix 1) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for NHLH1 Gene

  • May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system

Gene Wiki entry for NHLH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLH1 Gene

Genomics for NHLH1 Gene

Regulatory Elements for NHLH1 Gene

Genomic Location for NHLH1 Gene

160,367,067 bp from pter
160,372,848 bp from pter
5,782 bases
Plus strand

Genomic View for NHLH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NHLH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLH1 Gene

Proteins for NHLH1 Gene

  • Protein details for NHLH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Helix-loop-helix protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for NHLH1 Gene

    133 amino acids
    Molecular mass:
    14618 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein

neXtProt entry for NHLH1 Gene

Proteomics data for NHLH1 Gene at MOPED

Post-translational modifications for NHLH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHLH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NHLH1 Gene

Domains for NHLH1 Gene

Gene Families for NHLH1 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for NHLH1 Gene

Suggested Antigen Peptide Sequences for NHLH1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q02575
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NHLH1: view

Function for NHLH1 Gene

Molecular function for NHLH1 Gene

GENATLAS Biochemistry: nescient helix loop helix protein 1,binding the E-box motif,transciently expressed during neuro-genesis,involved in retinal development. Also expressed in neuroblastoma cell line
UniProtKB/Swiss-Prot Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system

Gene Ontology (GO) - Molecular Function for NHLH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 12878195
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 12878195
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NHLH1: view
genes like me logo Genes that share phenotypes with NHLH1: view

Animal Models for NHLH1 Gene

MGI Knock Outs for NHLH1:

Animal Model Products

CRISPR Products

Transcription Factor Targeting for NHLH1 Gene

Selected GeneGlobe predicted Target genes for NHLH1

No data available for Enzyme Numbers (IUBMB) , miRNA and HOMER Transcription for NHLH1 Gene

Localization for NHLH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NHLH1 Gene

Subcellular locations from

Jensen Localization Image for NHLH1 Gene COMPARTMENTS Subcellular localization image for NHLH1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NHLH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NHLH1: view

Pathways for NHLH1 Gene

SuperPathways for NHLH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NHLH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007417 central nervous system development TAS 1328219
GO:0030154 cell differentiation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12878195
genes like me logo Genes that share ontologies with NHLH1: view

No data available for Pathways by source for NHLH1 Gene

Transcripts for NHLH1 Gene

mRNA/cDNA for NHLH1 Gene

(19) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NHLH1 Gene

Nescient helix loop helix 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NHLH1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NHLH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHLH1 Gene

No ASD Table

Relevant External Links for NHLH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHLH1 Gene

mRNA expression in normal human tissues for NHLH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NHLH1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.3), Brain - Putamen (basal ganglia) (4.2), and Brain - Caudate (basal ganglia) (4.2).

SOURCE GeneReport for Unigene cluster for NHLH1 Gene Hs.30956

genes like me logo Genes that share expressions with NHLH1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for NHLH1 Gene

Orthologs for NHLH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NHLH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHLH1 35
  • 99.25 (n)
  • 100 (a)
NHLH1 36
  • 100 (a)
(Bos Taurus)
Mammalia NHLH1 35
  • 90.73 (n)
  • 96.99 (a)
NHLH1 36
  • 97 (a)
(Canis familiaris)
Mammalia NHLH1 35
  • 89.9 (n)
  • 94.7 (a)
NHLH1 36
  • 95 (a)
(Mus musculus)
Mammalia Nhlh1 35
  • 88.97 (n)
  • 92.48 (a)
Nhlh1 16
Nhlh1 36
  • 92 (a)
(Monodelphis domestica)
Mammalia NHLH1 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Nhlh1 35
  • 88.97 (n)
  • 93.23 (a)
(Gallus gallus)
Aves NHLH1 35
  • 78.46 (n)
  • 76.92 (a)
NHLH1 36
  • 80 (a)
(Anolis carolinensis)
Reptilia NHLH1 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhlh1 35
  • 68.75 (n)
  • 77.34 (a)
(Danio rerio)
Actinopterygii nhlh2 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta HLH4C 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea hlh-15 36
  • 65 (a)
Species with no ortholog for NHLH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NHLH1 Gene

Gene Tree for NHLH1 (if available)
Gene Tree for NHLH1 (if available)

Paralogs for NHLH1 Gene

Paralogs for NHLH1 Gene

Selected SIMAP similar genes for NHLH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NHLH1: view

Variants for NHLH1 Gene

Sequence variations from dbSNP and Humsavar for NHLH1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2147472 -- 160,372,086(+) CCTCT(A/G)AAAAT utr-variant-3-prime
rs7521304 -- 160,372,225(+) ATAGC(G/T)CAGGG utr-variant-3-prime
rs10637656 -- 160,372,372(+) TTTAT(-/TTAT)AAATA utr-variant-3-prime
rs10908777 -- 160,369,481(+) agttc(C/T)atttt intron-variant
rs10908778 -- 160,371,352(+) TTTAT(C/T)GCTGA utr-variant-3-prime

Relevant External Links for NHLH1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NHLH1 Gene

Disorders for NHLH1 Gene

(1) Novoseek inferred disease relationships for NHLH1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with NHLH1: view

No data available for UniProtKB/Swiss-Prot for NHLH1 Gene

Publications for NHLH1 Gene

  1. A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. (PMID: 1328219) Lipkowitz S. … Kirsch I.R. (J. Biol. Chem. 1992) 3 4 23
  2. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. (PMID: 10603358) Bao J. … Gautier J. (Development 2000) 3 23
  3. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. (PMID: 1528853) Brown L. … Baer R. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for NHLH1 Gene

Sources for NHLH1 Gene

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