Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NHLH1 Gene

protein-coding   GIFtS: 50
GCID: GC01P160336

Nescient Helix Loop Helix 1


(Previous symbol: HEN1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nescient Helix Loop Helix 11 2 3     bHLHa352 3
HEN11 2 3 5     NSCL2
Class A Basic Helix-Loop-Helix Protein 352 3     NSCL12
HEN-12 3     Helix-Loop-Helix Protein 12
NSCL-12 3     BHLHA353

External Ids:    HGNC: 78171   Entrez Gene: 48072   Ensembl: ENSG000001717867   OMIM: 1623605   UniProtKB: Q025753   

Export aliases for NHLH1 gene to outside databases

Previous GC identifers: GC01P158128 GC01P156069 GC01P157114 GC01P157553 GC01P157149 GC01P158603 GC01P131693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NHLH1 Gene:
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown
to play an important role in growth and development of a wide variety of tissues and species. Four members of
this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in
lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).(supplied by OMIM,
Nov 2002)

GeneCards Summary for NHLH1 Gene:
NHLH1 (nescient helix loop helix 1) is a protein-coding gene. Diseases associated with NHLH1 include meningitis, and tonsillitis. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is TWIST1.

UniProtKB/Swiss-Prot: HEN1_HUMAN, Q02575
Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly
within the developing nervous system

Gene Wiki entry for NHLH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NHLH1 gene promoter:
         CUTL1   Meis-1b   C/EBPalpha   GATA-2   AREB6   HOXA5   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNHLH1 promoter sequence
   Search Chromatin IP Primers for NHLH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NHLH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q22

NHLH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NHLH1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160336:  view genomic region     (about GC identifiers)

Start:
160,336,857 bp from pter      End:
160,342,638 bp from pter
Size:
5,782 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HEN1_HUMAN, Q02575 (See protein sequence)
Recommended Name: Helix-loop-helix protein 1  
Size: 133 amino acids; 14618 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein

Explore the universe of human proteins at neXtProt for NHLH1: NX_Q02575

REFSEQ proteins: NP_005589.1  
ENSEMBL proteins: 
 ENSP00000302189  

NHLH1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for NHLH1
OriGene Protein Over-expression Lysate for NHLH1
OriGene MassSpec for NHLH1
OriGene Custom Protein Services for NHLH1
GenScript Custom Purified and Recombinant Proteins Services for NHLH1
Novus Biologicals NHLH1 Proteins
Novus Biologicals NHLH1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for NHLH1
Cloud-Clone Corp. Proteins for NHLH1

NHLH1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for NHLH1
OriGene Custom Antibody Services for NHLH1
Novus Biologicals NHLH1 Antibodies
Abcam antibodies for NHLH1 (Q02577, Q02575)
Cloud-Clone Corp. Antibodies for NHLH1
Search ThermoFisher Antibodies for NHLH1
LSBio Antibodies in human, mouse, rat for NHLH1

NHLH1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for NHLH1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for NHLH1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for NHLH1
Cloud-Clone Corp. CLIAs for NHLH1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
bHLH: Basic helix-loop-helix proteins

1 InterPro protein domain:
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q02575

ProtoNet protein and cluster: Q02575

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: HEN1_HUMAN, Q02575
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


NHLH1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HEN1_HUMAN, Q02575
Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly
within the developing nervous system

     Genatlas biochemistry entry for NHLH1:
nescient helix loop helix protein 1,binding the E-box motif,transciently expressed during neuro-genesis,involved
in retinal development. Also expressed in neuroblastoma cell line

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0046983protein dimerization activity IEA--
     
NHLH1 for ontologies           About GeneDecksing


Phenotypes:
     4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nhlh1):
 behavior/neurological  cardiovascular system  mortality/aging  nervous system 

NHLH1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Nhlh1tm1Irk for NHLH1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NHLH1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NHLH1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NHLH1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NHLH1

Transcription Factor Targeting: 
Selected GeneGlobe predicted Target genes for NHLH1 (see all 843):
ABCC10,  ABCG5,  ABHD12B,  ACAD9,  ACAP3,  ACSM5,  ACTL7A,  ACTL7B,  ADAMTS14,  ADCYAP1R1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat NHLH1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NHLH1 (see all 25):
hsa-miR-3149 hsa-miR-1321 hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-340 hsa-miR-3680 hsa-miR-124
SwitchGear 3'UTR luciferase reporter plasmidNHLH1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for NHLH1
Predesigned siRNA for gene silencing in human, mouse, rat NHLH1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for NHLH1

Clone
Products:
     
OriGene clones in human, mouse for NHLH1 (see all 6)
OriGene ORF clones in mouse, rat for NHLH1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NHLH1 (NM_005598)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHLH1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for NHLH1
Browse ESI BIO Cell Lines and PureStem Progenitors for NHLH1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
HEN1_HUMAN, Q02575: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

NHLH1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for NHLH1 About    
See pathways by source

SuperPathContained pathways About
1Transcription factors in neurogenesis
Transcription factors in neurogenesis



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NHLH1
Interactions:

    GeneGlobe Interaction Network for NHLH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for NHLH1 (Q025753 ENSP000003021894) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
LMO2P257913, ENSP000002578184I2D: score=3 STRING: ENSP00000257818
LMO1P258003, ENSP000003382074I2D: score=2 STRING: ENSP00000338207
LMO4P619683, ENSP000003595734I2D: score=2 STRING: ENSP00000359573
CSRP3P504613, ENSP000002659684I2D: score=1 STRING: ENSP00000265968
TCF3P159233, ENSP000002629654I2D: score=1 STRING: ENSP00000262965
About this table

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--
GO:0007417central nervous system development TAS1328219
GO:0030154cell differentiation IEA--

NHLH1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NHLH1 (HEN1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for NHLH1 gene: 
NM_005598.3  

Unigene Cluster for NHLH1:

Nescient helix loop helix 1
Hs.30956  [show with all ESTs]
Unigene Representative Sequence: M96739
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000302101(uc001fwa.2)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NHLH1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NHLH1 (see all 25):
hsa-miR-3149 hsa-miR-1321 hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-340 hsa-miR-3680 hsa-miR-124
SwitchGear 3'UTR luciferase reporter plasmidNHLH1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NHLH1
Predesigned siRNA for gene silencing in human, mouse, rat NHLH1
Clone
Products:
     
OriGene clones in human, mouse for NHLH1 (see all 6)
OriGene ORF clones in mouse, rat for NHLH1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NHLH1 (NM_005598)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NHLH1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for NHLH1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NHLH1
  QuantiTect SYBR Green Assays in human, mouse, rat NHLH1
  QuantiFast Probe-based Assays in human, mouse, rat NHLH1

Additional mRNA sequence: 

AK313700.1 BC013789.1 BT006859.1 M96739.1 

1 DOTS entry:

DT.80102035 

19 AceView cDNA sequences:

H09935 NM_005598 BC013789 BU173483 BU187004 AI733105 AI793327 AA910905 
AI733300 BT006859 M96739 AI791602 BX113024 AI951857 AA932591 H09936 
BE778250 BI916874 AW090793 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

NHLH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCTTTGCTT
NHLH1 Expression
About this image


NHLH1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebellum
 
 Pancreas (Endocrine System)    fully expand to see all 3 entries
         Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
         Islets of Langerhans
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 NULL (Uncategorized)
         Neural rosettes
NHLH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.30956
    Custom PCR Arrays for NHLH1
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for NHLH1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NHLH1
QuantiTect SYBR Green Assays in human, mouse, rat NHLH1
QuantiFast Probe-based Assays in human, mouse, rat NHLH1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for NHLH1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nhlh11 , 5 nescient helix loop helix 11, 5 88.97(n)1
92.48(a)1
  1 (79.54 cM)5
180711  NM_010916.21  NP_035046.11 
 1720522925 
chicken
(Gallus gallus)
Aves NHLH11 nescient helix loop helix 1 78.46(n)
76.92(a)
  373910  NM_204121.1  NP_989452.1 
lizard
(Anolis carolinensis)
Reptilia NHLH16
nescient helix loop helix 1
90(a)
1 ↔ 1
AAWZ02040013(2204-2462)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nhlh11 nescient helix loop helix 1 68.75(n)
77.34(a)
  100125788  XM_002937261.2  XP_002937307.1 
zebrafish
(Danio rerio)
Actinopterygii nhlh26
nescient helix loop helix 2
68(a)
1 → many
9(34011610-34014968) ENSDARG00000025495
fruit fly
(Drosophila melanogaster)
Insecta HLH4C6
Helix loop helix protein 4C
45(a)
1 → many
X(4539160-4541447)
worm
(Caenorhabditis elegans)
Secernentea hlh-156
Protein HLH-15 (hlh-15) mRNA, complete cds
65(a)
1 → many
X(2412969-2413288) WBGene00001959


ENSEMBL Gene Tree for NHLH1 (if available)
TreeFam Gene Tree for NHLH1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for NHLH1 gene
TWIST12  TWIST22  HAND22  TAL12  NHLH22  LYL12  TAL22  TCF152  
SCXB2  HAND12  SCXA2  
9 SIMAP similar genes for NHLH1 using alignment to 2 protein entries:     HEN1_HUMAN (see all proteins):
SCL    TAL1    tal-1    TAL2    NHLH2    FERD3L
LYL1    HAND1    TCF15

NHLH1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for NHLH1 (see all 132)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1165030861,2
C,F--160334883(+) CCCCAT/AGAGAC 1 -- us2k11Minor allele frequency- A:0.14WA 118
rs800463271,2
F--160334908(+) TCCCTA/GTGTCT 1 -- us2k11Minor allele frequency- G:0.01WA 118
rs2002642061,2
--160334949(+) TCTCA-/TTTTTT 1 -- us2k10--------
rs1815188471,2
--160334997(+) TCGTCA/GTTTCC 1 -- us2k10--------
rs1430835941,2
C--160335147(+) TTGCT-/GGGGGG 1 -- us2k10--------
rs727066881,2
--160335318(+) CAGGTA/GGGAGT 1 -- us2k10--------
rs1151843231,2
C,F--160335432(+) TTGACC/TAGCAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1869008501,2
--160335519(+) CTCCCG/TTAATT 1 -- us2k10--------
rs741231841,2
C,F--160335591(+) TCAAAA/GGGTTG 1 -- us2k13Minor allele frequency- G:0.22WA CSA 121
rs1404774791,2
--160335668(+) CTCCAC/GTCATG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for NHLH1 (160336857 - 160342638 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NHLH1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NHLH1
DNA2.0 Custom Variant and Variant Library Synthesis for NHLH1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 162360    OMIM disorders: --

11 diseases for NHLH1:    
About MalaCards
meningitis    tonsillitis    neuroblastoma    retinitis
cerebritis    malaria    thyroiditis    neuronitis
pancreatitis    endotheliitis    prostatitis


NHLH1 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for NHLH1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 1 17507989 (1)


Export disorders for NHLH1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for NHLH1 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with NHLH1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. (PubMed id 1328219)1, 2, 9 Lipkowitz S....Kirsch I.R. (J. Biol. Chem. 1992)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. (PubMed id 1528853)1, 2 Brown L.... Baer R. (Proc. Natl. Acad. Sci. U.S.A. 1992)
  4. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. (PubMed id 10603358)1, 9 Bao J....Gautier J. (Development 2000)
  5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  8. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. (PubMed id 12878195)1 Manetopoulos C....Axelson H. (Biochem. Biophys. Res. Commun. 2003)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. (PubMed id 1729708)1 Begley C.G....Kirsch I.R. (Proc. Natl. Acad. Sci. U.S.A. 1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 4807 HGNC: 7817 AceView: NHLH1 Ensembl:ENSG00000171786 euGenes: HUgn4807
ECgene: NHLH1 H-InvDB: NHLH1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for NHLH1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NHLH1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for NHLH1 gene:
Search GeneIP for patents involving NHLH1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for NHLH1   OriGene RNAi products in human, mouse, rat for NHLH1  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NHLH1  
 OriGene MassSpec something-or-other for NHLH1   OriGene clones in human, mouse for NHLH1  
 OriGene qSTAR qPCR primer pairs in human, mouse for NHLH1   OriGene Purified Protein for NHLH1  
 OriGene ORF clones in mouse, rat for NHLH1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for NHLH1   OriGene Custom Protein Services for NHLH1  

 
 
 Block miRNA regulation of human, mouse, rat NHLH1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NHLH1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NHLH1 Predesigned siRNA for gene silencing in human, mouse, rat NHLH1
 QuantiFast Probe-based Assays in human, mouse, rat NHLH1 QuantiTect SYBR Green Assays in human, mouse, rat NHLH1
 Custom PCR Arrays for NHLH1 Search Chromatin IP Primers for NHLH1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NHLH1  GeneGlobe Interaction Network for NHLH1
 Regulatory tfbs in NHLH1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for NHLH1 GenScript cDNA clones with any tag delivered in your preferred vector for NHLH1
 GenScript Custom Assay Services for NHLH1 GenScript Custom overexpressing Cell Line Services for NHLH1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for NHLH1 (HEN1)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 NHLH1 antibodies
 NHLH1 proteins
 NHLH1 lysates
 Antibodies for NHLH1
 See all of Abcam's Antibodies, Kits and Proteins for NHLH1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for NHLH1
 Proteins for NHLH1
 Antibodies for NHLH1
 ELISAs for NHLH1
 CLIAs for NHLH1



 Browse ESI BIO Cell Lines and PureStem Progenitors for NHLH1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHLH1
 SwitchGear 3'UTR luciferase reporter plasmids for NHLH1
 SwitchGear Promoter luciferase reporter plasmids for NHLH1
 Search ThermoFisher Antibodies for NHLH1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NHLH1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NHLH1
 LSBio Antibodies in human, mouse, rat for NHLH1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      NHLH1 gene at Home site.
Version: 3.12.164 25 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4