Aliases for NHLH1 Gene
External Ids for NHLH1 Gene
Previous HGNC Symbols for NHLH1 Gene
Previous GeneCards Identifiers for NHLH1 Gene
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]
GeneCards Summary for NHLH1 Gene
NHLH1 (Nescient Helix-Loop-Helix 1) is a Protein Coding gene. Diseases associated with NHLH1 include Cleft Palate, Isolated and Orofacial Cleft. GO annotations related to this gene include protein dimerization activity and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is NHLH2.
UniProtKB/Swiss-Prot for NHLH1 Gene
May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.