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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NHLH1 Gene

protein-coding   GIFtS: 52
GCID: GC01P160336

nescient helix loop helix 1


(Previous symbol: HEN1)
 Explore 3 diseases affiliated with
NHLH1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NHLH1    

Aliases
for NHLH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nescient Helix Loop Helix 11 2 3     Class A Basic Helix-Loop-Helix Protein 352 3
HEN11 2 3 5     HEN-12 3
BHLHa351     NSCL-12 3
NSCL1 2     Helix-Loop-Helix Protein 12
NSCL11 2     BHLHA353

External Ids:    HGNC: 78171   Entrez Gene: 48072   Ensembl: ENSG000001717867   OMIM: 1623605   UniProtKB: Q025753   

Export aliases for NHLH1 gene to outside databases

Previous GC identifers: GC01P158128 GC01P156069 GC01P157114 GC01P157553 GC01P157149 GC01P158603 GC01P131693


Summaries
for NHLH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NHLH1:
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to
play an important role in growth and development of a wide variety of tissues and species. Four members of this family
have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors:
MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).(supplied by OMIM, Nov 2002)

UniProtKB/Swiss-Prot: HEN1_HUMAN, Q02575
Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly
within the developing nervous system

Gene Wiki entry for NHLH1


Genomic Views
for NHLH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NHLH1 gene promoter:
         CUTL1   Meis-1b   C/EBPalpha   GATA-2   AREB6   HOXA5   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NHLH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NHLH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHLH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q22

NHLH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NHLH1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160336:  view genomic region     (about GC identifiers)

Start:
 160,336,857 bp from pter      End:
 160,342,638 bp from pter
Size:
 5,782 bases      Orientation:
 plus strand

Proteins
for NHLH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HEN1_HUMAN, Q02575 (See protein sequence)
Recommended Name: Helix-loop-helix protein 1  
Size: 133 amino acids; 14618 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for NHLH1: NX_Q02575

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02575

    • NHLH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005589.1  
    ENSEMBL proteins: 
     ENSP00000302189  

    Human Recombinant Protein Products: 
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    Novus Biologicals NHLH1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NHLH1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    NHLH1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NHLH1

    Protein Domains /
    Families
    for NHLH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NHLH1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q02575

    ProtoNet protein and cluster: Q02575

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: HEN1_HUMAN, Q02575
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for NHLH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HEN1_HUMAN, Q02575
    Function: May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly
    within the developing nervous system

         Genatlas biochemistry entry for NHLH1:
    nescient helix loop helix protein 1,binding the E-box motif,transciently expressed during neuro-genesis,involved in
    retinal development. Also expressed in neuroblastoma cell line

    10/871 SABiosciences Target genes for NHLH1 (see all 871):
    ABCC10 ABCG5 ABHD12B ACAD9 ACAP3 ACSM5 ACTL7A ACTL7B ADAMTS14 ADCYAP1R1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NHLH1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate NHLH1 (see all 25):
    hsa-miR-3149 hsa-miR-1321 hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-340 hsa-miR-3680 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: NHLH1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHLH1 (see all 7)
    OriGene shRNA RFP: NHLH1
    OriGene siRNA: NHLH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHLH1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NHLH1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NHLH1

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046983protein dimerization activity IEA--


    NHLH1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nhlh1tm1Irk for NHLH1
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nhlh1):
     behavior/neurological  cardiovascular system  mortality/aging  nervous system 

    NHLH1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NHLH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NHLH1
        Transcription factors in neurogenesis




    NHLH1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NHLH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for NHLH1 (Q025753 ENSP000003021894) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO2P257913, ENSP000002578184I2D: score=3 STRING: ENSP00000257818
    LMO1P258003, ENSP000003382074I2D: score=2 STRING: ENSP00000338207
    LMO4P619683, ENSP000003595734I2D: score=2 STRING: ENSP00000359573
    CSRP3P504613, ENSP000002659684I2D: score=1 STRING: ENSP00000265968
    TCF3P159233, ENSP000002629654I2D: score=1 STRING: ENSP00000262965
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007417central nervous system development TAS1328219
    GO:0030154cell differentiation IEA--


    NHLH1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NHLH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NHLH1
    Search CenterWatch for drugs/clinical trials and news about NHLH1 / HEN1 

    Transcripts
    for NHLH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NHLH1 gene: 
    NM_005598.3  

    Unigene Cluster for NHLH1:

    Nescient helix loop helix 1
    Hs.30956  [show with all ESTs]
    Unigene Representative Sequence: M96739
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302101(uc001fwa.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NHLH1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate NHLH1 (see all 25):
    hsa-miR-3149 hsa-miR-1321 hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-340 hsa-miR-3680 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: NHLH1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHLH1 (see all 7)
    OriGene shRNA RFP: NHLH1
    OriGene siRNA: NHLH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHLH1
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHLH1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHLH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHLH1

    Additional cDNA sequence: 

    AK313700.1 BC013789.1 BT006859.1 M96739.1 

    1 DOTS entry:

    DT.80102035 

    19 AceView cDNA sequences:

    H09935 BX113024 AI733105 AA910905 NM_005598 AI733300 BT006859 BU187004 
    BC013789 AI791602 AI793327 BU173483 M96739 AA932591 AI951857 H09936 
    BE778250 BI916874 AW090793 

    GeneLoc Exon Structure


    Expression
    for NHLH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NHLH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTTTGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NHLH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    BrainHypothalamusBrain
    BrainMeningesBrain
    EyeRetinaEye
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NHLH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NHLH1

    SOURCE GeneReport for Unigene cluster: Hs.30956
        SABiosciences Custom PCR Arrays for NHLH1
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    In Situ
    Assay Products:     
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    Orthologs
    for NHLH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NHLH1 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NHLH11 nescient helix loop helix 1 80(n)
    79.23(a)    		   373910  NM_204121.1  NP_989452.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NHLH16
    		 --
    		 87(a)
    		 1 ↔ 1
    		 AAWZ02040013(2205-2456)
    fruit fly
    (Drosophila melanogaster)    		 Insecta HLH4C1 Helix loop helix protein 4C 74.12(n)
    88.16(a)    		   31397  NM_057641.3  NP_476989.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea hlh-151 Protein HLH-15 57.89(n)
    67.11(a)    		   183427  NM_076039.1  NP_508440.1 


    ENSEMBL Gene Tree for NHLH1 (if available)
    TreeFam Gene Tree for NHLH1 (if available) 

    Paralogs
    for NHLH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NHLH1 gene
    TCF242  TWIST12  TWIST22  TAL12  HAND22  TCF232  LYL12  NHLH22  
    TAL22  TCF152  SCXB2  TCF212  HAND12  MSC2  SCXA2  
    10 SIMAP similar genes for NHLH1 using alignment to 2 protein entries:     HEN1_HUMAN (see all proteins):
    SCL    TAL1    tal-1    TAL2    NHLH2    FERD3L
    LYL1    HAND1    TCF15    PTF1A

    NHLH1 for paralogs           About GeneDecksing



    Genomic Variants
    for NHLH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 NCBI SNPs in NHLH1 are shown (see all 105)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1165030861,2
    		F,--160334883(+) CCCCAT/AGAGAC 1 -- us2k11Minor allele frequency- A:0.14WA 118
    rs800463271,2
    		--160334908(+) TCCCTA/GTGTCT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs2002642061,2
    		--160334949(+) TCTCA-/TTTTTT 1 -- us2k10--------
    rs1815188471,2
    		--160334997(+) TCGTCA/GTTTCC 1 -- us2k10--------
    rs1430835941,2
    		C,--160335147(+) TTGCT-/GGGGGG 1 -- us2k10--------
    rs727066881,2
    		--160335318(+) CAGGTA/GGGAGT 1 -- us2k10--------
    rs1151843231,2
    		F,--160335432(+) TTGACC/TAGCAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1869008501,2
    		--160335519(+) CTCCCG/TTAATT 1 -- us2k10--------
    rs741231841,2
    		C,--160335591(+) TCAAAA/GGGTTG 1 -- us2k13Minor allele frequency- G:0.22WA CSA 121
    rs1404774791,2
    		--160335668(+) CTCCAC/GTCATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NHLH1 (160336857 - 160342638 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NHLH1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHLH1
    DNA2.0 Custom Variant and Variant Library Synthesis for NHLH1

    Disorders / Diseases
    for NHLH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NHLH1 for disorders           About GeneDecksing

    OMIM gene information: 162360    OMIM disorders: --

    3 diseases for NHLH1:    About MalaCards
    neuroblastoma    retinitis    neuronitis

    1 Novoseek disease relationship for NHLH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 17507989 (1)


    Export disorders for NHLH1 gene to outside databases

    Publications
    for NHLH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NHLH1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with NHLH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. (PubMed id 1328219)1, 2, 9 Lipkowitz S....Kirsch I.R. (1992)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. (PubMed id 1528853)1, 2 Brown L.... Baer R. (1992)
    4. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. (PubMed id 10603358)1, 9 Bao J....Gautier J. (2000)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. (PubMed id 12878195)1 Manetopoulos C....Axelson H. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. (PubMed id 1729708)1 Begley C.G....Kirsch I.R. (1992)
    10. NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. (PubMed id 15470499)9 Kruger M....Braun T. (2004)

    External Searches for NHLH1 gene

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    Genome Databases showing NHLH1 gene

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    Entrez Gene: 4807 HGNC: 7817 AceView: NHLH1 Ensembl:ENSG00000171786 euGenes: HUgn4807
    ECgene: NHLH1 H-InvDB: NHLH1

    Other Databases showing NHLH1 gene

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    Specialized Databases showing NHLH1 gene

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    PharmGKB entry for NHLH1 Pharmacogenomics, SNPs, Pathways
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