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Aliases for NHLH1 Gene

Aliases for NHLH1 Gene

  • Nescient Helix-Loop-Helix 1 2 3 5
  • Nescient Helix Loop Helix 1 2 3 4
  • Class A Basic Helix-Loop-Helix Protein 35 3 4
  • BHLHa35 3 4
  • NSCL-1 3 4
  • HEN-1 3 4
  • HEN1 3 4
  • NSCL1 3
  • NSCL 3

External Ids for NHLH1 Gene

Previous HGNC Symbols for NHLH1 Gene

  • HEN1

Previous GeneCards Identifiers for NHLH1 Gene

  • GC01P158128
  • GC01P156069
  • GC01P157114
  • GC01P157553
  • GC01P157149
  • GC01P158603
  • GC01P160336
  • GC01P131693
  • GC01P160367

Summaries for NHLH1 Gene

Entrez Gene Summary for NHLH1 Gene

  • The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]

GeneCards Summary for NHLH1 Gene

NHLH1 (Nescient Helix-Loop-Helix 1) is a Protein Coding gene. Diseases associated with NHLH1 include Orofacial Cleft and Physical Disorder. GO annotations related to this gene include protein dimerization activity and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for NHLH1 Gene

  • May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

Gene Wiki entry for NHLH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLH1 Gene

Genomics for NHLH1 Gene

Regulatory Elements for NHLH1 Gene

Enhancers for NHLH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NHLH1 on UCSC Golden Path with GeneCards custom track

Promoters for NHLH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NHLH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NHLH1 Gene

160,286,369 bp from pter
160,372,848 bp from pter
86,480 bases
Plus strand

Genomic View for NHLH1 Gene

Genes around NHLH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHLH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHLH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLH1 Gene

Proteins for NHLH1 Gene

  • Protein details for NHLH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Helix-loop-helix protein 1
    Protein Accession:

    Protein attributes for NHLH1 Gene

    133 amino acids
    Molecular mass:
    14618 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NHLH1 Gene

Proteomics data for NHLH1 Gene at MOPED

Post-translational modifications for NHLH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHLH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NHLH1 Gene

Domains & Families for NHLH1 Gene

Gene Families for NHLH1 Gene

Protein Domains for NHLH1 Gene

Suggested Antigen Peptide Sequences for NHLH1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NHLH1: view

Function for NHLH1 Gene

Molecular function for NHLH1 Gene

GENATLAS Biochemistry:
nescient helix loop helix protein 1,binding the E-box motif,transciently expressed during neuro-genesis,involved in retinal development. Also expressed in neuroblastoma cell line
UniProtKB/Swiss-Prot Function:
May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

Gene Ontology (GO) - Molecular Function for NHLH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NHLH1: view
genes like me logo Genes that share phenotypes with NHLH1: view

Animal Models for NHLH1 Gene

MGI Knock Outs for NHLH1:

Animal Model Products

CRISPR Products

miRNA for NHLH1 Gene

miRTarBase miRNAs that target NHLH1

Transcription Factor Targets for NHLH1 Gene

Selected GeneGlobe predicted Target genes for NHLH1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for NHLH1 Gene

Localization for NHLH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NHLH1 Gene

Subcellular locations from

Jensen Localization Image for NHLH1 Gene COMPARTMENTS Subcellular localization image for NHLH1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for NHLH1 Gene

Pathways & Interactions for NHLH1 Gene

SuperPathways for NHLH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NHLH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12878195
genes like me logo Genes that share ontologies with NHLH1: view

No data available for Pathways by source and SIGNOR curated interactions for NHLH1 Gene

Drugs & Compounds for NHLH1 Gene

No Compound Related Data Available

Transcripts for NHLH1 Gene

mRNA/cDNA for NHLH1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NHLH1 Gene

Nescient helix loop helix 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NHLH1 Gene

No ASD Table

Relevant External Links for NHLH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHLH1 Gene

mRNA expression in normal human tissues for NHLH1 Gene

mRNA differential expression in normal tissues according to GTEx for NHLH1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.3), Brain - Putamen (basal ganglia) (x4.2), and Brain - Caudate (basal ganglia) (x4.2).

SOURCE GeneReport for Unigene cluster for NHLH1 Gene Hs.30956

genes like me logo Genes that share expression patterns with NHLH1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NHLH1 Gene

Orthologs for NHLH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NHLH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NHLH1 35
  • 90.73 (n)
  • 96.99 (a)
NHLH1 36
  • 97 (a)
(Canis familiaris)
Mammalia NHLH1 35
  • 89.9 (n)
  • 94.7 (a)
NHLH1 36
  • 95 (a)
(Mus musculus)
Mammalia Nhlh1 35
  • 88.97 (n)
  • 92.48 (a)
Nhlh1 16
Nhlh1 36
  • 92 (a)
(Pan troglodytes)
Mammalia NHLH1 35
  • 99.25 (n)
  • 100 (a)
NHLH1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nhlh1 35
  • 88.97 (n)
  • 93.23 (a)
(Monodelphis domestica)
Mammalia NHLH1 36
  • 95 (a)
(Gallus gallus)
Aves NHLH1 35
  • 78.46 (n)
  • 76.92 (a)
NHLH1 36
  • 80 (a)
(Anolis carolinensis)
Reptilia NHLH1 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhlh1 35
  • 68.75 (n)
  • 77.34 (a)
(Danio rerio)
Actinopterygii nhlh2 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta HLH4C 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea hlh-15 36
  • 65 (a)
Species with no ortholog for NHLH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NHLH1 Gene

Gene Tree for NHLH1 (if available)
Gene Tree for NHLH1 (if available)

Paralogs for NHLH1 Gene

Paralogs for NHLH1 Gene

(9) SIMAP similar genes for NHLH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NHLH1: view

Variants for NHLH1 Gene

Sequence variations from dbSNP and Humsavar for NHLH1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2147472 -- 160,372,086(+) CCTCT(A/G)AAAAT utr-variant-3-prime
rs4656256 -- 160,361,229(+) ATATT(A/G)GGATG intron-variant
rs4656902 -- 160,363,952(+) CAAAT(G/T)TAGTA intron-variant
rs6693771 -- 160,365,036(+) CCAtt(C/T)ttttt intron-variant
rs7521304 -- 160,372,225(+) ATAGC(G/T)CAGGG utr-variant-3-prime

Variation tolerance for NHLH1 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NHLH1 Gene

Disorders for NHLH1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NHLH1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
orofacial cleft
physical disorder
  • physical illness
popliteal pterygium syndrome 1
  • popliteal pterygium syndrome
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search NHLH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NHLH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NHLH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NHLH1 Gene

Publications for NHLH1 Gene

  1. A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system. (PMID: 1328219) Lipkowitz S. … Kirsch I.R. (J. Biol. Chem. 1992) 3 4 23 67
  2. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. (PMID: 10603358) Bao J. … Gautier J. (Development 2000) 3 23
  3. Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia. (PMID: 25243493) Chen C. … Liu C. (Bipolar Disord 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for NHLH1 Gene

Sources for NHLH1 Gene