NHEJ1 Gene
protein-coding GIFtS: 57
GCID: GC02M219941
|
|
nonhomologous end-joining factor 1
| |
Aliases
for NHEJ1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nonhomologous End-Joining Factor 11 2 | | Cernunnos1 | | XLF1 2 3 5 | | FLJ126101 | | Protein Cernunnos2 3 | | Non-Homologous End-Joining Factor 12 | | XRCC4-Like Factor2 3 | | |
Export aliases for NHEJ1 gene to outside databasesPrevious GC identifers: GC02M219648 GC02M211793 |
Summaries
for NHEJ1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NHEJ1:
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This geneencodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repairof double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NHEJ1_HUMAN, Q9H9Q4Function: DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB)repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, ormay participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may actin concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatchedends that are noncomplementary or partially complementary
Gene Wiki entry for NHEJ1 (XLF)
|
Genomic Views
for NHEJ1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NHEJ1 gene promoter:
AhR E47 Egr-4 YY1 AREB6 POU2F1 POU2F1a FOXO1a NF-kappaB1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NHEJ1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHEJ1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35NHEJ1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M219941: view genomic region
(about GC identifiers)
Start:
|
219,940,039 bp from pter |
End:
|
220,025,587 bp from pter |
Size:
|
85,549 bases |
Orientation:
|
minus strand |
|
Proteins
for NHEJ1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NHEJ1_HUMAN, Q9H9Q4 (See
protein sequence)Recommended Name: Non-homologous end-joining factor 1 Size: 299 amino acids; 33337 Da
Subunit: Interacts with XRCC4 and the XRCC4-LIG4 complex. Binds DNA in a length-dependent manner
Subcellular location: Nucleus
Miscellaneous: Was named 'Cernunnos' after the enigmatic Celtic god of hunting, the underworld and fertility
6 PDB 3D structures from  and Proteopedia  for NHEJ1:2QM4 (3D)
2R9A (3D)
3Q4F (3D)
3RWR (3D)
3SR2 (3D)
3W03 (3D)
Secondary accessions: B8ZZA4 Q4ZFW7 Q6IA64 Q96JS9Alternative splicing: 2 isoforms: Q9H9Q4-1 Q9H9Q4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NHEJ1: NX_Q9H9Q4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9Q4
NHEJ1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079058.1
ENSEMBL proteins: ENSP00000387290 ENSP00000349313 ENSP00000408966 ENSP00000394896 ENSP00000407201 ENSP00000408421
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NHEJ1 for ontologies About GeneDecksing
NHEJ1 Antibody Products:
Assay Products for NHEJ1: |
Protein
Domains /
Families
for NHEJ1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NHEJ1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9Q4ProtoNet protein and cluster: Q9H9Q4 UniProtKB/Swiss-Prot: NHEJ1_HUMAN, Q9H9Q4Similarity: Belongs to the XLF family |
Function
for NHEJ1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NHEJ1_HUMAN, Q9H9Q4Function: DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB)repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, ormay participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may actin concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatchedends that are noncomplementary or partially complementary
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHEJ1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHEJ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NHEJ1 (NM_024782) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHEJ1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHEJ1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHEJ1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NHEJ1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NHEJ1:
Animal Models:
Mouse knock-out Nhej1tm1Fwa for NHEJ1
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nhej1):
NHEJ1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NHEJ1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Non-homologous end-joining | | | 2 | DNA Damage | | | 3 | Cell Cycle / Checkpoint Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for NHEJ1
1  BioSystems Pathway for NHEJ1
1 
Kegg Pathway (Kegg details for NHEJ1):
NHEJ1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NHEJ1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/12 Interacting proteins for NHEJ1 (Q9H9Q41, 2, 3 ENSP000003493134) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
NHEJ1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NHEJ1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NHEJ1
Search CenterWatch for drugs/clinical trials and news about NHEJ1
|
Transcripts
for NHEJ1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NHEJ1 gene: NM_024782.2 Unigene Cluster for NHEJ1: Nonhomologous end-joining factor 1 Hs.225988 [show with all ESTs]Unigene Representative Sequence: NM_02478210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409720 ENST00000356853(uc002vjp.4) ENST00000418099 ENST00000494211
ENST00000426304 ENST00000491159 ENST00000483627 ENST00000457600 ENST00000450447
ENST00000481764
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHEJ1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHEJ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NHEJ1 (NM_024782) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NHEJ1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHEJ1 |
Additional cDNA sequence: AJ972687.1 AK022672.1 BC008210.2 BC012732.2 BC030986.1 CR457291.1 6 DOTS entries: DT.109237 DT.120995373 DT.101983042 DT.100755275 DT.100755274 DT.91967038 24/81 AceView cDNA sequences (see all 81): BF591227 BX280520 AA515515 AI263078 AI734010 AK055730 BC008210 AK125121 AW296385 CR596901 BX280407 CB134508 AW156986 AK091919 BQ071822 BC012732 CA436268 CA436271 AA758027 BX506147 BX401823 AW167520 AW079355 CR457291
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NHEJ1 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | · | 24c | · | 24d | · | 24e | · | 24f |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NHEJ1
|
Expression
for NHEJ1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NHEJ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTACCACG
About this image
See NHEJ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NHEJ1
SOURCE GeneReport for Unigene cluster: Hs.225988
UniProtKB/Swiss-Prot: NHEJ1_HUMAN, Q9H9Q4Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for NHEJ1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHEJ1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NHEJ1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHEJ1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHEJ1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHEJ1 |
Orthologs
for NHEJ1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NHEJ1 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nhej11 , 5 |
nonhomologous end-joining factor 11, 5 |
81.13(n)1
74.92(a)1 |
|
1 (38.56 cM)5
755701 NM_029342.41 NP_083618.31
749671395 |
chicken
(Gallus gallus) |
Aves |
NHEJ11 |
nonhomologous end-joining factor 1 |
54.3(n)
50.17(a) |
|
424205 XM_422052.3 XP_422052.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NHEJ16 |
-- |
55(a) |
1 ↔ 1 |
1(88163716-88171683) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.23432 |
Xenopus laevis transcribed sequence with weak similarity more |
79.36(n) |
|
AW638661.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
nhej11 |
nonhomologous end-joining factor 1 |
47.73(n)
38.78(a) |
|
406593 NM_214749.1 NP_999914.1 |
ENSEMBL Gene Tree for NHEJ1 (if available)
TreeFam Gene Tree for NHEJ1 (if available) |
Paralogs
for NHEJ1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NHEJ1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NHEJ1 (219940039 - 220025587 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NHEJ1
1 CNV: 98139
Human Gene Mutation Database (HGMD): NHEJ1
Locus Specific Mutation Databases (LSDB): NHEJ1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHEJ1 |
|
Disorders
/ Diseases
for NHEJ1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NHEJ1 for disorders About GeneDecksing
OMIM gene information: 611290
OMIM disorders: 611291
UniProtKB/Swiss-Prot: NHEJ1_HUMAN, Q9H9Q4
Defects in NHEJ1 are the cause of severe combined immunodeficiency due to NHEJ1 deficiency (NHEJ1-SCID)[MIM:611291]; also known as autosomal recessive T-cell-negative, B-cell-negative, NK cell-positive, severe combinedimmunodeficiency with microcephaly, growth retardation and sensitivity to ionizing radiation or NHEJ1 syndrome. SCIDrefers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment ofboth humoral and cell-mediated immunity, leukopenia and low or absent antibody levels. Patients with SCID present ininfancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types ofSCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. NHEJ1-SCID ischaracterized by a profound T- and B-lymphocytopenia associated with increased cellular sensitivity to ionizingradiation, microcephaly and growth retardation. Some patients may manifest SCID with sensitivity to ionizing radiationwithout microcephaly and mild growth retardation, probably due to hypomorphic NHEJ1 mutations Note=A chromosomal aberration involving NHEJ1 is found in a patient with polymicrogyria. Translocationt(2;7)(q35;p22)
13  diseases for NHEJ1: About MalaCardssevere combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation severe combined immunodeficiency combined immunodeficiency dna ligase iv deficiency
immunodeficiency nijmegen breakage syndrome microcephaly t-lymphocytopenia
polymicrogyria lymphopenia leukopenia multiple sclerosis
meningioma
2 diseases from the University of Copenhagen DISEASES database for NHEJ1:DNA ligase IV deficiency Nijmegen breakage syndrome Human Genome Epidemiology (HuGE) Navigator: NHEJ1 (4 documents)
Export disorders for NHEJ1 gene to outside databases
|
Publications
for NHEJ1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NHEJ1 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with NHEJ1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. (PubMed id 16439205)1, 2, 3, 9 Ahnesorg P....Jackson S.P. (2006)
- Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. (PubMed id 16439204)1, 2, 3 Buck D.... Revy P. (2006)
- Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity. (PubMed id 17317666)1, 2, 9 Lu H....Lieber M.R. (2007)
- Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. (PubMed id 17470781)1, 2, 9 Tsai C.J....Chu G. (2007)
- Truncation of NHEJ1 in a patient with polymicrogyria. (PubMed id 17191205)1, 2 Cantagrel V.... Villard L. (2007)
- Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1. (PubMed id 16571728)1, 2 Callebaut I....de Villartay J.P. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Nonhomologous end joining and V(D)J recombination require an additional factor. (PubMed id 12604777)1, 2 Dai Y.... Jeggo P.A. (2003)
|
External Searches for NHEJ1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NHEJ1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NHEJ1 gene
(According to HUGE)
About This Section
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Specialized Databases showing NHEJ1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for NHEJ1 | Pharmacogenomics, SNPs, Pathways | | NHEJ1base | http://bioinf.uta.fi/NHEJ1base/ |
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About This Section
| Patent Information for NHEJ1 gene:
Search GeneIP for patents involving NHEJ1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NHEJ1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for NHEJ1 | | OriGene shRNA RFP for NHEJ1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NHEJ1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NHEJ1 | | | OriGene Protein Over-expression Lysate for NHEJ1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for NHEJ1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NHEJ1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NHEJ1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NHEJ1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NHEJ1 | | OriGene Custom Protein Services for NHEJ1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NHEJ1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NHEJ1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NHEJ1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NHEJ1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NHEJ1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NHEJ1 |
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| | Antibodies & Assays for NHEJ1 |
| | | | Search Tocris compounds for NHEJ1 |
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 | | | NHEJ1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NHEJ1 |
|  |  |  | | | | ThermoFisher Antibodies for NHEJ1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NHEJ1 |
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