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Aliases for NGRN Gene

Aliases for NGRN Gene

  • Neugrin, Neurite Outgrowth Associated 2 3
  • Neurite Outgrowth-Associated Protein 3 4
  • Mesenchymal Stem Cell Protein DSC92 3 4
  • Spinal Cord-Derived Protein FI58G 3 4
  • Neurite Outgrowth Associated Protein 3
  • Neugrin 3
  • DSC92 3
  • FI58G 4

External Ids for NGRN Gene

Previous GeneCards Identifiers for NGRN Gene

  • GC15P088596
  • GC15P088609
  • GC15P090808
  • GC15P066920

Summaries for NGRN Gene

GeneCards Summary for NGRN Gene

NGRN (Neugrin, Neurite Outgrowth Associated) is a Protein Coding gene. Diseases associated with NGRN include neuroblastoma.

UniProtKB/Swiss-Prot for NGRN Gene

  • May be involved in neuronal differentiation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGRN Gene

Genomics for NGRN Gene

Regulatory Elements for NGRN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NGRN Gene

Start:
90,265,659 bp from pter
End:
90,278,141 bp from pter
Size:
12,483 bases
Orientation:
Plus strand

Genomic View for NGRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NGRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGRN Gene

Proteins for NGRN Gene

  • Protein details for NGRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPE2-NGRN_HUMAN
    Recommended name:
    Neugrin
    Protein Accession:
    Q9NPE2
    Secondary Accessions:
    • B2R6M8
    • Q4V9L7
    • Q9HBL4

    Protein attributes for NGRN Gene

    Size:
    291 amino acids
    Molecular mass:
    32408 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65447.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAG09725.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAG09725.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305}; Sequence=AAH01682.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH07222.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH09389.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH17192.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB21533.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB21533.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305}; Sequence=BAG35525.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG35525.1; Type=Miscellaneous discrepancy; Note=N-terminus does not match isoform 2.; Evidence={ECO:0000305}; Sequence=CAB96088.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAD39160.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NGRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGRN Gene

Proteomics data for NGRN Gene at MOPED

Post-translational modifications for NGRN Gene

  • Glycosylation at Asn158, Asn186, and Asn268
  • Modification sites at PhosphoSitePlus

Other Protein References for NGRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NGRN Gene

Domains for NGRN Gene

Protein Domains for NGRN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPE2

UniProtKB/Swiss-Prot:

NGRN_HUMAN :
  • Q9NPE2
Family:
  • Belongs to the neugrin family.
genes like me logo Genes that share domains with NGRN: view

No data available for Gene Families for NGRN Gene

Function for NGRN Gene

Molecular function for NGRN Gene

UniProtKB/Swiss-Prot Function: May be involved in neuronal differentiation
UniProtKB/Swiss-Prot Induction: Highly up-regulated in neuroblastostoma cells by retinoic acid treatment inducing neurite outgrowth

Gene Ontology (GO) - Molecular Function for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NGRN: view

Phenotypes for NGRN Gene

MGI mutant phenotypes for NGRN:
inferred from 1 alleles
GenomeRNAi human phenotypes for NGRN:
genes like me logo Genes that share phenotypes with NGRN: view

Animal Model Products

CRISPR Products

miRNA for NGRN Gene

miRTarBase miRNAs that target NGRN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NGRN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NGRN Gene

Localization for NGRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGRN Gene

Nucleus. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGRN Gene COMPARTMENTS Subcellular localization image for NGRN gene
Compartment Confidence
nucleus 5
extracellular 3
cytoskeleton 1
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus NAS 11118320
genes like me logo Genes that share ontologies with NGRN: view

Pathways for NGRN Gene

SuperPathways for NGRN Gene

No Data Available

Interacting Proteins for NGRN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368389%0d%0a9606.ENSP00000233944%0d%0a9606.ENSP00000301585%0d%0a
Selected Interacting proteins: Q9NPE2-NGRN_HUMAN ENSP00000368389 for NGRN Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030182 neuron differentiation NAS 11118320
genes like me logo Genes that share ontologies with NGRN: view

No data available for Pathways by source for NGRN Gene

Transcripts for NGRN Gene

mRNA/cDNA for NGRN Gene

Unigene Clusters for NGRN Gene

Neugrin, neurite outgrowth associated:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NGRN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NGRN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGRN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for NGRN Gene

GeneLoc Exon Structure for
NGRN
ECgene alternative splicing isoforms for
NGRN

Expression for NGRN Gene

mRNA expression in normal human tissues for NGRN Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NGRN Gene

SOURCE GeneReport for Unigene cluster for NGRN Gene Hs.135471

mRNA Expression by UniProt/SwissProt for NGRN Gene

Q9NPE2-NGRN_HUMAN
Tissue specificity: Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells.
genes like me logo Genes that share expressions with NGRN: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NGRN Gene

Orthologs for NGRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGRN 35
  • 99.08 (n)
  • 98.28 (a)
NGRN 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NGRN 35
  • 82.57 (n)
  • 74.56 (a)
NGRN 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGRN 35
  • 84.48 (n)
  • 78.97 (a)
NGRN 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngrn 35
  • 79.43 (n)
  • 72.07 (a)
Ngrn 16
Ngrn 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngrn 35
  • 78.51 (n)
  • 72.76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ngrn 35
  • 50.54 (n)
  • 41.58 (a)
zebrafish
(Danio rerio)
Actinopterygii NGRN 36
  • 33 (a)
OneToOne
si:ch211-199o1.5 35
  • 48.81 (n)
  • 41.2 (a)
Species with no ortholog for NGRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGRN Gene

ENSEMBL:
Gene Tree for NGRN (if available)
TreeFam:
Gene Tree for NGRN (if available)

Paralogs for NGRN Gene

genes like me logo Genes that share paralogs with NGRN: view

No data available for Paralogs for NGRN Gene

Variants for NGRN Gene

Sequence variations from dbSNP and Humsavar for NGRN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs6897 -- 90,272,055(+) TGTTG(C/T)TACAA utr-variant-3-prime, nc-transcript-variant
rs2882857 -- 90,268,393(+) AAGAG(A/G)AAAAA intron-variant
rs3029942 -- 90,268,392(+) TAAGA(-/GG)AAAAA intron-variant
rs10588270 -- 90,268,957(+) CCCCC(-/CCC)ATTAT intron-variant
rs11073922 - 90,271,432(+) CTTTG(C/T)TTATG reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NGRN Gene

Variant ID Type Subtype PubMed ID
dgv776e1 CNV Complex 17122850
dgv2435n71 CNV Loss 21882294
nsv833087 CNV Loss 17160897
essv11326 CNV CNV 17122850
esv2751541 CNV Gain 17911159

Relevant External Links for NGRN Gene

HapMap Linkage Disequilibrium report
NGRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGRN Gene

Disorders for NGRN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NGRN Gene including...

Search for NGRN Gene in MalaCards »

(1) Novoseek inferred disease relationships for NGRN Gene

Disease -log(P) Hits PubMed IDs
inflammation 16.1 1
genes like me logo Genes that share disorders with NGRN: view

No data available for UniProtKB/Swiss-Prot for NGRN Gene

Publications for NGRN Gene

  1. Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. (PMID: 11118320) Ishigaki S. … Sobue G. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis. (PMID: 12417341) Ishigaki S. … Sobue G. (FEBS Lett. 2002) 23
  3. Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression. (PMID: 15477757) Hustinx S.R. … Hruban R.H. (Cancer Biol. Ther. 2004) 23
  4. Identification of differentially expressed genes in metastatic and non-metastatic nasopharyngeal carcinoma cells by suppression subtractive hybridization. (PMID: 16308470) Yang X.Y. … Yao K.T. (Cell. Oncol. 2005) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NGRN Gene

  • Addgene plasmids for NGRN

Sources for NGRN Gene

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