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Aliases for NGRN Gene

Aliases for NGRN Gene

  • Neugrin, Neurite Outgrowth Associated 2 3 5
  • Mesenchymal Stem Cell Protein DSC92 3 4
  • Spinal Cord-Derived Protein FI58G 3 4
  • Neurite Outgrowth Associated Protein 3
  • Neurite Outgrowth-Associated Protein 4
  • Neugrin 3
  • DSC92 3
  • FI58G 4

External Ids for NGRN Gene

Previous GeneCards Identifiers for NGRN Gene

  • GC15P088596
  • GC15P088609
  • GC15P090808
  • GC15P066920

Summaries for NGRN Gene

GeneCards Summary for NGRN Gene

NGRN (Neugrin, Neurite Outgrowth Associated) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ENSG00000275674.

UniProtKB/Swiss-Prot for NGRN Gene

  • May be involved in neuronal differentiation.

Additional gene information for NGRN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGRN Gene

Genomics for NGRN Gene

Regulatory Elements for NGRN Gene

Enhancers for NGRN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H090157 2 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -102.1 -102118 12 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 CIB1 RCCD1 SEMA4B RPL36AP43 GDPGP1 NGRN ENSG00000259314 UNC45A GABARAPL3 ZNF774
GH15H090209 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -53.2 -53173 5 HDAC1 TBP SIN3A FEZF1 BATF RAD21 TCF12 GATA2 SCRT2 ZNF143 SEMA4B CIB1 GDPGP1 IDH2 NGRN IQGAP1 ENSG00000228998 TTLL13P RPS12P26 PIR48569
GH15H090141 1.6 Ensembl ENCODE dbSUPER 11.3 -122.8 -122821 2 PKNOX1 ARNT SIN3A ZNF2 ZNF766 ZNF143 DEK SP3 REST SMARCB1 CIB1 UNC45A NGRN GDPGP1 POLG IDH2 TTLL13P SEMA4B GC15M090124
GH15H090153 1.5 Ensembl ENCODE dbSUPER 11.6 -110.7 -110736 1 PKNOX1 FOXA2 ZNF133 ARID4B FEZF1 ZNF2 YY1 GLIS2 FOS ATF7 CIB1 GDPGP1 NGRN GABARAPL3 ZNF774 SEMA4B IDH2 GC15M090124
GH15H090148 1.5 Ensembl ENCODE dbSUPER 11.2 -116.3 -116274 1 HDGF FOXA2 ATF1 ARNT ARID4B YY1 GATA2 ATF7 RUNX3 JUNB CIB1 GDPGP1 NGRN GABARAPL3 ZNF774 SEMA4B TTLL13P GC15M090124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NGRN on UCSC Golden Path with GeneCards custom track

Promoters for NGRN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000081033 341 2001 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766

Genomic Location for NGRN Gene

Chromosome:
15
Start:
90,265,659 bp from pter
End:
90,278,141 bp from pter
Size:
12,483 bases
Orientation:
Plus strand

Genomic View for NGRN Gene

Genes around NGRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGRN Gene

Proteins for NGRN Gene

  • Protein details for NGRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPE2-NGRN_HUMAN
    Recommended name:
    Neugrin
    Protein Accession:
    Q9NPE2
    Secondary Accessions:
    • B2R6M8
    • Q4V9L7
    • Q9HBL4

    Protein attributes for NGRN Gene

    Size:
    291 amino acids
    Molecular mass:
    32408 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65447.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAG09725.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAG09725.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305}; Sequence=AAH01682.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH07222.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH09389.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH17192.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB21533.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB21533.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305}; Sequence=BAG35525.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG35525.1; Type=Miscellaneous discrepancy; Note=N-terminus does not match isoform 2.; Evidence={ECO:0000305}; Sequence=CAB96088.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAD39160.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NGRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGRN Gene

Post-translational modifications for NGRN Gene

  • Glycosylation at Asn158, posLast=186186, and posLast=268268
  • Modification sites at PhosphoSitePlus

Other Protein References for NGRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NGRN Gene

Domains & Families for NGRN Gene

Gene Families for NGRN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NGRN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPE2

UniProtKB/Swiss-Prot:

NGRN_HUMAN :
  • Belongs to the neugrin family.
Family:
  • Belongs to the neugrin family.
genes like me logo Genes that share domains with NGRN: view

Function for NGRN Gene

Molecular function for NGRN Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.
UniProtKB/Swiss-Prot Induction:
Highly up-regulated in neuroblastostoma cells by retinoic acid treatment inducing neurite outgrowth.

Phenotypes From GWAS Catalog for NGRN Gene

Gene Ontology (GO) - Molecular Function for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NGRN: view
genes like me logo Genes that share phenotypes with NGRN: view

Animal Models for NGRN Gene

MGI Knock Outs for NGRN:
  • Ngrn tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NGRN
  • Applied Biological Materials Clones for NGRN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NGRN Gene

Localization for NGRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGRN Gene

Nucleus. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGRN gene
Compartment Confidence
extracellular 4
nucleus 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus NAS,IBA 11118320
genes like me logo Genes that share ontologies with NGRN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NGRN Gene

Pathways & Interactions for NGRN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
GO:0030182 neuron differentiation NAS 11118320
genes like me logo Genes that share ontologies with NGRN: view

No data available for Pathways by source and SIGNOR curated interactions for NGRN Gene

Drugs & Compounds for NGRN Gene

No Compound Related Data Available

Transcripts for NGRN Gene

Unigene Clusters for NGRN Gene

Neugrin, neurite outgrowth associated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NGRN
  • Applied Biological Materials Clones for NGRN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NGRN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for NGRN Gene

GeneLoc Exon Structure for
NGRN
ECgene alternative splicing isoforms for
NGRN

Expression for NGRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NGRN Gene

Protein differential expression in normal tissues from HIPED for NGRN Gene

This gene is overexpressed in Heart (45.2) and Oral epithelium (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NGRN Gene



Protein tissue co-expression partners for NGRN Gene

NURSA nuclear receptor signaling pathways regulating expression of NGRN Gene:

NGRN

SOURCE GeneReport for Unigene cluster for NGRN Gene:

Hs.135471

mRNA Expression by UniProt/SwissProt for NGRN Gene:

Q9NPE2-NGRN_HUMAN
Tissue specificity: Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells.

Evidence on tissue expression from TISSUES for NGRN Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Muscle(4.5)
  • Kidney(4.3)
  • Pancreas(3.8)
  • Skin(2.8)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with NGRN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NGRN Gene

Orthologs for NGRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGRN 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia NGRN 33 34
  • 84.48 (n)
cow
(Bos Taurus)
Mammalia NGRN 33 34
  • 82.57 (n)
mouse
(Mus musculus)
Mammalia Ngrn 33 16 34
  • 79.43 (n)
rat
(Rattus norvegicus)
Mammalia Ngrn 33
  • 78.51 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ngrn 33
  • 50.54 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-199o1.5 33
  • 48.81 (n)
NGRN 34
  • 33 (a)
OneToOne
Species where no ortholog for NGRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGRN Gene

ENSEMBL:
Gene Tree for NGRN (if available)
TreeFam:
Gene Tree for NGRN (if available)

Paralogs for NGRN Gene

Paralogs for NGRN Gene

genes like me logo Genes that share paralogs with NGRN: view

Variants for NGRN Gene

Sequence variations from dbSNP and Humsavar for NGRN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000280670 -- 90,267,815(+) AGACA(A/G)ATGCA intron-variant
rs1000284543 -- 90,268,001(+) TTTTC(-/GTTT)GTTTG intron-variant
rs1000696502 -- 90,268,020(+) TTTTT(A/G)TTTGA intron-variant
rs1003068902 -- 90,269,924(+) TTCTT(A/G)AAATA intron-variant
rs1003409078 -- 90,271,312(+) AGAAG(A/C)TGAAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NGRN Gene

Variant ID Type Subtype PubMed ID
esv2751541 CNV gain 17911159
esv2760054 CNV gain 17122850
esv3637218 CNV gain 21293372
nsv1052652 CNV gain 25217958
nsv833087 CNV loss 17160897
nsv976963 CNV duplication 23825009

Variation tolerance for NGRN Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NGRN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGRN Gene

Disorders for NGRN Gene

Relevant External Links for NGRN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NGRN

No disorders were found for NGRN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NGRN Gene

Publications for NGRN Gene

  1. Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. (PMID: 11118320) Ishigaki S … Sobue G (Biochemical and biophysical research communications 2000) 2 3 4 22 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2. (PMID: 27337956) Li Q … Xiong W (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  4. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. (PMID: 27667664) Arroyo JD … Mootha VK (Cell metabolism 2016) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for NGRN Gene

  • Addgene plasmids for NGRN

Sources for NGRN Gene

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