Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NGRN Gene

Aliases for NGRN Gene

  • Neugrin, Neurite Outgrowth Associated 2 3
  • Neurite Outgrowth-Associated Protein 3 4
  • Mesenchymal Stem Cell Protein DSC92 3 4
  • Spinal Cord-Derived Protein FI58G 3 4
  • Neurite Outgrowth Associated Protein 3
  • DSC92 3
  • FI58G 4

External Ids for NGRN Gene

Previous GeneCards Identifiers for NGRN Gene

  • GC15P088596
  • GC15P088609
  • GC15P090808
  • GC15P066920

Summaries for NGRN Gene

GeneCards Summary for NGRN Gene

NGRN (Neugrin, Neurite Outgrowth Associated) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for NGRN Gene

  • May be involved in neuronal differentiation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGRN Gene

Genomics for NGRN Gene

Regulatory Elements for NGRN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NGRN Gene

Chromosome:
15
Start:
90,265,659 bp from pter
End:
90,278,141 bp from pter
Size:
12,483 bases
Orientation:
Plus strand

Genomic View for NGRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NGRN Gene

Proteins for NGRN Gene

  • Protein details for NGRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPE2-NGRN_HUMAN
    Recommended name:
    Neugrin
    Protein Accession:
    Q9NPE2
    Secondary Accessions:
    • B2R6M8
    • Q4V9L7
    • Q9HBL4

    Protein attributes for NGRN Gene

    Size:
    291 amino acids
    Molecular mass:
    32408 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65447.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAG09725.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAG09725.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305}; Sequence=AAH01682.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH07222.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH09389.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH17192.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB21533.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB21533.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305}; Sequence=BAG35525.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG35525.1; Type=Miscellaneous discrepancy; Note=N-terminus does not match isoform 2.; Evidence={ECO:0000305}; Sequence=CAB96088.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAD39160.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NGRN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGRN Gene

Proteomics data for NGRN Gene at MOPED

Post-translational modifications for NGRN Gene

  • Glycosylation at Asn 158, Asn 186, and Asn 268
  • Modification sites at PhosphoSitePlus

Other Protein References for NGRN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NGRN Gene

Domains & Families for NGRN Gene

Protein Domains for NGRN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPE2

UniProtKB/Swiss-Prot:

NGRN_HUMAN :
  • Belongs to the neugrin family.
Family:
  • Belongs to the neugrin family.
genes like me logo Genes that share domains with NGRN: view

No data available for Gene Families for NGRN Gene

Function for NGRN Gene

Molecular function for NGRN Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation
UniProtKB/Swiss-Prot Induction:
Highly up-regulated in neuroblastostoma cells by retinoic acid treatment inducing neurite outgrowth

Gene Ontology (GO) - Molecular Function for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NGRN: view
genes like me logo Genes that share phenotypes with NGRN: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NGRN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NGRN Gene

Localization for NGRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGRN Gene

Nucleus. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGRN Gene COMPARTMENTS Subcellular localization image for NGRN gene
Compartment Confidence
nucleus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus NAS 11118320
genes like me logo Genes that share ontologies with NGRN: view

Pathways & Interactions for NGRN Gene

SuperPathways for NGRN Gene

No Data Available

Interacting Proteins for NGRN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368389%0d%0a9606.ENSP00000233944%0d%0a9606.ENSP00000301585%0d%0a
Selected Interacting proteins: Q9NPE2-NGRN_HUMAN ENSP00000368389 for NGRN Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for NGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030182 neuron differentiation NAS 11118320
genes like me logo Genes that share ontologies with NGRN: view

No data available for Pathways by source and SIGNOR curated interactions for NGRN Gene

Drugs & Compounds for NGRN Gene

No Compound Related Data Available

Transcripts for NGRN Gene

mRNA/cDNA for NGRN Gene

Unigene Clusters for NGRN Gene

Neugrin, neurite outgrowth associated:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NGRN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGRN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for NGRN Gene

GeneLoc Exon Structure for
NGRN
ECgene alternative splicing isoforms for
NGRN

Expression for NGRN Gene

mRNA expression in normal human tissues for NGRN Gene

Protein differential expression in normal tissues from HIPED for NGRN Gene

This gene is overexpressed in Heart (45.2) and Oral epithelium (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NGRN Gene



SOURCE GeneReport for Unigene cluster for NGRN Gene Hs.135471

mRNA Expression by UniProt/SwissProt for NGRN Gene

Q9NPE2-NGRN_HUMAN
Tissue specificity: Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells.
genes like me logo Genes that share expression patterns with NGRN: view

Protein tissue co-expression partners for NGRN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NGRN Gene

Orthologs for NGRN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGRN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NGRN 35
  • 82.57 (n)
  • 74.56 (a)
NGRN 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGRN 35
  • 84.48 (n)
  • 78.97 (a)
NGRN 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngrn 35
  • 79.43 (n)
  • 72.07 (a)
Ngrn 16
Ngrn 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NGRN 35
  • 99.08 (n)
  • 98.28 (a)
NGRN 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngrn 35
  • 78.51 (n)
  • 72.76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ngrn 35
  • 50.54 (n)
  • 41.58 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-199o1.5 35
  • 48.81 (n)
  • 41.2 (a)
NGRN 36
  • 33 (a)
OneToOne
Species with no ortholog for NGRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGRN Gene

ENSEMBL:
Gene Tree for NGRN (if available)
TreeFam:
Gene Tree for NGRN (if available)

Paralogs for NGRN Gene

genes like me logo Genes that share paralogs with NGRN: view

No data available for Paralogs for NGRN Gene

Variants for NGRN Gene

Sequence variations from dbSNP and Humsavar for NGRN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs6897 -- 90,272,055(+) TGTTG(C/T)TACAA utr-variant-3-prime, nc-transcript-variant
rs2882857 -- 90,268,393(+) AAGAG(A/G)AAAAA intron-variant
rs3029942 -- 90,268,392(+) TAAGA(-/GA/GG)AAAAA intron-variant
rs10588270 -- 90,268,957(+) CCCCC(-/CCC)ATTAT intron-variant
rs11073922 - 90,271,432(+) CTTTG(C/G/T)TTATG reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NGRN Gene

Variant ID Type Subtype PubMed ID
dgv776e1 CNV Complex 17122850
dgv2435n71 CNV Loss 21882294
nsv833087 CNV Loss 17160897
essv11326 CNV CNV 17122850
esv2751541 CNV Gain 17911159

Variation tolerance for NGRN Gene

Residual Variation Intolerance Score: 75.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NGRN Gene

HapMap Linkage Disequilibrium report
NGRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGRN Gene

Disorders for NGRN Gene

Relevant External Links for NGRN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NGRN
genes like me logo Genes that share disorders with NGRN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NGRN Gene

Publications for NGRN Gene

  1. Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. (PMID: 11118320) Ishigaki S. … Sobue G. (Biochem. Biophys. Res. Commun. 2000) 2 23 67
  2. Identification of differentially expressed genes in metastatic and non-metastatic nasopharyngeal carcinoma cells by suppression subtractive hybridization. (PMID: 16308470) Yang X.Y. … Yao K.T. (Cell. Oncol. 2005) 23 67
  3. Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression. (PMID: 15477757) Hustinx S.R. … Hruban R.H. (Cancer Biol. Ther. 2004) 23 67
  4. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis. (PMID: 12417341) Ishigaki S. … Sobue G. (FEBS Lett. 2002) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for NGRN Gene

Sources for NGRN Gene

Back to Top

Content