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Aliases for NGFRAP1 Gene

Aliases for NGFRAP1 Gene

  • Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 2 3
  • DXS6984E 3 4 6
  • BEX3 3 4 6
  • NADE 3 4 6
  • Ovarian Granulosa Cell 13.0 KDa Protein HGR74 3 4
  • P75NTR-Associated Cell Death Executor 3 4
  • Brain-Expressed X-Linked Protein 3 3 4
  • Nerve Growth Factor Receptor-Associated Protein 1 4
  • Brain Expressed 2
  • Protein BEX3 3
  • X-Linked 3 2
  • HGR74 3
  • Bex 3

External Ids for NGFRAP1 Gene

Previous GeneCards Identifiers for NGFRAP1 Gene

  • GC0XP097933
  • GC0XP099540
  • GC0XP100664
  • GC0XP101403
  • GC0XP102437
  • GC0XP102631
  • GC0XP092293

Summaries for NGFRAP1 Gene

GeneCards Summary for NGFRAP1 Gene

NGFRAP1 (Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process and death receptor binding. An important paralog of this gene is BEX2.

UniProtKB/Swiss-Prot for NGFRAP1 Gene

  • May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.

Gene Wiki entry for NGFRAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGFRAP1 Gene

Genomics for NGFRAP1 Gene

Regulatory Elements for NGFRAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NGFRAP1 Gene

Start:
103,376,323 bp from pter
End:
103,378,164 bp from pter
Size:
1,842 bases
Orientation:
Plus strand

Genomic View for NGFRAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NGFRAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGFRAP1 Gene

Proteins for NGFRAP1 Gene

  • Protein details for NGFRAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00994-BEX3_HUMAN
    Recommended name:
    Protein BEX3
    Protein Accession:
    Q00994
    Secondary Accessions:
    • B2RD17
    • D3DXA3
    • Q5JQT4
    • Q5JQT5

    Protein attributes for NGFRAP1 Gene

    Size:
    111 amino acids
    Molecular mass:
    12959 Da
    Quaternary structure:
    • Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR.
    Miscellaneous:
    • Binds transition metals.

    Three dimensional structures from OCA and Proteopedia for NGFRAP1 Gene

    Alternative splice isoforms for NGFRAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGFRAP1 Gene

Proteomics data for NGFRAP1 Gene at MOPED

Post-translational modifications for NGFRAP1 Gene

Other Protein References for NGFRAP1 Gene

Antibody Products

  • R&D Systems Antibodies for NGFRAP1 (NGFRAP1/BEX3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NGFRAP1

No data available for DME Specific Peptides for NGFRAP1 Gene

Domains for NGFRAP1 Gene

Protein Domains for NGFRAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGFRAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00994

UniProtKB/Swiss-Prot:

BEX3_HUMAN :
  • Q00994
Domain:
  • The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with NGFRAP1: view

No data available for Gene Families for NGFRAP1 Gene

Function for NGFRAP1 Gene

Molecular function for NGFRAP1 Gene

UniProtKB/Swiss-Prot Function:
May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.

Gene Ontology (GO) - Molecular Function for NGFRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005123 death receptor binding IEA --
GO:0005515 protein binding IPI 17355907
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process TAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NGFRAP1: view
genes like me logo Genes that share phenotypes with NGFRAP1: view

Animal Model Products

CRISPR Products

miRNA for NGFRAP1 Gene

miRTarBase miRNAs that target NGFRAP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NGFRAP1 Gene

Localization for NGFRAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGFRAP1 Gene

Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGFRAP1 Gene COMPARTMENTS Subcellular localization image for NGFRAP1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for NGFRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NGFRAP1: view

Pathways for NGFRAP1 Gene

genes like me logo Genes that share pathways with NGFRAP1: view

Pathways by source for NGFRAP1 Gene

1 KEGG pathway for NGFRAP1 Gene
1 GeneGo (Thomson Reuters) pathway for NGFRAP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NGFRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007275 multicellular organismal development TAS 2171551
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA --
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NGFRAP1: view

Transcripts for NGFRAP1 Gene

Unigene Clusters for NGFRAP1 Gene

Nerve growth factor receptor (TNFRSF16) associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NGFRAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGFRAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for NGFRAP1 Gene

GeneLoc Exon Structure for
NGFRAP1
ECgene alternative splicing isoforms for
NGFRAP1

Expression for NGFRAP1 Gene

mRNA expression in normal human tissues for NGFRAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for NGFRAP1 Gene Hs.448588

mRNA Expression by UniProt/SwissProt for NGFRAP1 Gene

Q00994-BEX3_HUMAN
Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.
genes like me logo Genes that share expressions with NGFRAP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for NGFRAP1 Gene

Orthologs for NGFRAP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NGFRAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NGFRAP1 35
  • 93.39 (n)
  • 94.59 (a)
NGFRAP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGFRAP1 35
  • 93.99 (n)
  • 98.2 (a)
NGFRAP1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngfrap1 35
  • 88.89 (n)
  • 92.79 (a)
Ngfrap1 16
Ngfrap1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NGFRAP1 35
  • 100 (n)
  • 100 (a)
NGFRAP1 36
  • 100 (a)
OneToOne
Species with no ortholog for NGFRAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NGFRAP1 Gene

ENSEMBL:
Gene Tree for NGFRAP1 (if available)
TreeFam:
Gene Tree for NGFRAP1 (if available)

Paralogs for NGFRAP1 Gene

Paralogs for NGFRAP1 Gene

Selected SIMAP similar genes for NGFRAP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NGFRAP1: view

Variants for NGFRAP1 Gene

Sequence variations from dbSNP and Humsavar for NGFRAP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14470 -- 103,377,855(-) TCACA(A/G)TATTA utr-variant-3-prime
rs1804033 -- 103,377,852(+) GATTA(A/G)TACTG utr-variant-3-prime
rs1804034 -- 103,377,679(+) TGGAG(A/T)TGGAG reference, missense
rs1804035 -- 103,377,611(+) CAGGC(C/T)CGCCG synonymous-codon, reference
rs1804036 -- 103,377,922(+) GCTGT(A/G)AACCC utr-variant-3-prime

Relevant External Links for NGFRAP1 Gene

HapMap Linkage Disequilibrium report
NGFRAP1
Human Gene Mutation Database (HGMD)
NGFRAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NGFRAP1 Gene

Disorders for NGFRAP1 Gene

No disorders were found for NGFRAP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NGFRAP1 Gene

Publications for NGFRAP1 Gene

  1. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. (PMID: 10764727) Mukai J. … Sato T.-A. (J. Biol. Chem. 2000) 2 3 4 23
  2. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E. … Freed C.R. (Gene 2005) 3 4 23
  3. Characterization of three abundant mRNAs from human ovarian granulosa cells. (PMID: 2171551) Rapp G. … Scheit K.H. (DNA Cell Biol. 1990) 2 3 4
  4. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  5. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. (PMID: 12739005) Tong X. … Koeffler H.P. (Int. J. Oncol. 2003) 3 23

Products for NGFRAP1 Gene

Sources for NGFRAP1 Gene

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