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NGFRAP1 Gene

protein-coding   GIFtS: 56
GCID: GC0XP102631

Nerve Growth Factor Receptor (TNFRSF16) Associated Protein...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 11 2     Brain Expressed1
BEX32 3 5     X-Linked 31
DXS6984E2 3 5     Bex2
NADE2 3 5     HGR742
Brain-Expressed X-Linked Protein 32 3     Protein BEX32
Ovarian Granulosa Cell 13.0 KDa Protein HGR742 3     Nerve Growth Factor Receptor-Associated Protein 13
P75NTR-Associated Cell Death Executor2 3     

External Ids:    HGNC: 133881   Entrez Gene: 270182   Ensembl: ENSG000001666817   OMIM: 3003615   UniProtKB: Q009943   

Export aliases for NGFRAP1 gene to outside databases

Previous GC identifers: GC0XP097933 GC0XP099540 GC0XP100664 GC0XP101403 GC0XP102437 GC0XP092293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NGFRAP1 Gene:
NGFRAP1 (nerve growth factor receptor (TNFRSF16) associated protein 1) is a protein-coding gene. Diseases associated with NGFRAP1 include aicardi syndrome, and neuronitis. GO annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process and death receptor binding. An important paralog of this gene is BEX1.

UniProtKB/Swiss-Prot: BEX3_HUMAN, Q00994
Function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role
in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic
diseases

Gene Wiki entry for NGFRAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NGFRAP1 gene promoter:
         MZF-1   HOXA3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NGFRAP1 promoter sequence
   Search Chromatin IP Primers for NGFRAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NGFRAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22.2

NGFRAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGFRAP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP102631:  view genomic region     (about GC identifiers)

Start:
102,631,268 bp from pter      End:
102,633,005 bp from pter
Size:
1,738 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BEX3_HUMAN, Q00994 (See protein sequence)
Recommended Name: Protein BEX3  
Size: 111 amino acids; 12959 Da
Subunit: Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds
to the DEATH domain of p75NTR/NGFR
Miscellaneous: Binds transition metals (By similarity)
1 PDB 3D structure from and Proteopedia for NGFRAP1:
1SA6 (3D)    
Secondary accessions: B2RD17 D3DXA3 Q5JQT4 Q5JQT5
Alternative splicing: 2 isoforms:  Q00994-1   Q00994-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NGFRAP1: NX_Q00994

Explore proteomics data for NGFRAP1 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Degraded by the proteasome (By similarity)1
  • Modification sites at neXtProt

  • See NGFRAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269603.1  NP_055195.1  NP_996798.1  NP_996800.1  

    ENSEMBL proteins: 
     ENSP00000354843   ENSP00000361728   ENSP00000361718   ENSP00000361717   ENSP00000299872  
    Reactome Protein details: Q00994

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021156 TF_A-like/BEX-like
     IPR007623 BEX

    Graphical View of Domain Structure for InterPro Entry Q00994

    ProtoNet protein and cluster: Q00994

    UniProtKB/Swiss-Prot: BEX3_HUMAN, Q00994
    Domain: The nuclear export signal is required for export from the nucleus and the interactions with itself and
    p75NTR/NGFR (By similarity)
    Similarity: Belongs to the BEX family


    NGFRAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BEX3_HUMAN, Q00994
    Function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role
    in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic
    diseases

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005123death receptor binding IEA--
    GO:0005515protein binding IPI17355907
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process TAS--
    GO:0046872metal ion binding IEA--
         
    NGFRAP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NGFRAP1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NGFRAP1
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    Block miRNA regulation of human, mouse, rat NGFRAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NGFRAP1 (see all 13):
    hsa-miR-3910 hsa-miR-196a* hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-128 hsa-miR-3681* hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidNGFRAP1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BEX3_HUMAN, Q00994: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with
    replicating mitochondria (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    NGFRAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NGFRAP1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NADE modulates death signalling0.00
    Cell death signalling via NRAGE, NRIF and NADE0.74
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58
    4Development HGF signaling pathway
    Neurotrophin signaling pathway0.36
    5Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NGFRAP1
        14-3-3 and Regulation of BAD Activity

    1 GeneGo (Thomson Reuters) Pathway for NGFRAP1
        Apoptosis and survival Apoptotic TNF-family pathways

    1 BioSystems Pathway for NGFRAP1
        p75(NTR)-mediated signaling


    1 Reactome Pathway for NGFRAP1
        NADE modulates death signalling


    1 Kegg Pathway  (Kegg details for NGFRAP1):
        Neurotrophin signaling pathway


    NGFRAP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NGFRAP1: 
              Neurotrophins & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NGFRAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NGFRAP1 (Q009941, 2, 3 ENSP000003617184) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66193 I2D: score=5 STRING: ENSP00000311695
    TSC1Q925741, 3, ENSP000002985524EBI-741753,EBI-1047085 I2D: score=3 STRING: ENSP00000298552
    NGFRP081383, ENSP000001722294I2D: score=3 STRING: ENSP00000172229
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    TRAF5O004633, ENSP000002614644I2D: score=1 STRING: ENSP00000261464
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0007275multicellular organismal development TAS2171551
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IEA--
    GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--

    NGFRAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NGFRAP1 (BEX3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NGFRAP1 gene (4 alternative transcripts): 
    NM_001282674.1  NM_014380.2  NM_206915.2  NM_206917.2  

    Unigene Cluster for NGFRAP1:

    Nerve growth factor receptor (TNFRSF16) associated protein 1
    Hs.448588  [show with all ESTs]
    Unigene Representative Sequence: BC051713
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361298(uc004eki.3 uc004ekh.3) ENST00000372645 ENST00000372635
    ENST00000372634 ENST00000299872(uc004ekj.1)
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    hsa-miR-3910 hsa-miR-196a* hsa-miR-513a-5p hsa-miR-27a hsa-miR-3120-3p hsa-miR-128 hsa-miR-3681* hsa-miR-545
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    Additional mRNA sequence: 

    AF187064.1 AK057859.1 AK315371.1 AY833562.1 BC003190.1 BC051713.1 M38188.1 

    15 DOTS entries:

    DT.100687029  DT.92449185  DT.101957151  DT.101985280  DT.92449177  DT.100876587  DT.100687009  DT.121282459 
    DT.121282466  DT.102831833  DT.121282455  DT.92449186  DT.95372052  DT.121282450  DT.121282471 

    Selected AceView cDNA sequences (see all 601):

    CR601593 AA649853 BF058872 BE408639 BM756565 AK057859 BQ021229 AA364476 
    BM272188 NM_206915 M38188 BQ787161 BM985004 BQ777941 CA950472 BU735527 
    CA848589 AW002096 AI088009 CA842929 AW160845 H24871 BM311142 BE732777 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NGFRAP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for NGFRAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NGFRAP1 expression in normal human tissues (normalized intensities)      NGFRAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAATTTA
    NGFRAP1 Expression
    About this image


    NGFRAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
    NGFRAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NGFRAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.448588

    UniProtKB/Swiss-Prot: BEX3_HUMAN, Q00994
    Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels
    also detected in liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NGFRAP1: 
              Neurotrophins & Receptors in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Necrosis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGFRAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for NGFRAP1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ngfrap11 , 5 nerve growth factor receptor (TNFRSF16) associated more1, 5 88.89(n)1
    92.79(a)1
      X (57.64 cM)5
    120701  NM_009750.21  NP_033880.11 
     1362702615 


    ENSEMBL Gene Tree for NGFRAP1 (if available)
    TreeFam Gene Tree for NGFRAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for NGFRAP1 gene
    BEX12  BEX52  BEX22  BEX42  
    4 SIMAP similar genes for NGFRAP1 using alignment to 2 protein entries:     BEX3_HUMAN (see all proteins):
    BEX4    BEX5    BEX1    BEX2

    NGFRAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NGFRAP1 (see all 66)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465219821,2
    --102599559(+) ATCGCA/GCCACT 1 -- us2k10--------
    rs1491398931,2
    C--102629332(+) TCTGGC/TTTAGC 2 -- us2k10--------
    rs66164651,2
    C--102629402(+) GCTTGC/TCTTGC 2 -- us2k10--------
    rs1864935551,2
    --102629565(+) CACTCA/GGGATA 2 -- us2k10--------
    rs346783491,2
    C--102630003(+) CACTG-/CACTCC 2 -- us2k10--------
    rs718508351,2
    C--102630004(+) ACTGA-/CCTCCA 2 -- us2k10--------
    rs1920979391,2
    --102630381(+) GAGCCA/GCCATG 3 -- us2k10--------
    rs2016744041,2
    C--102630445(+) GTGTG-/TGGAGCC 3 -- us2k10--------
    rs1839716371,2
    --102630483(+) TACAGA/GTCAAC 3 -- us2k10--------
    rs1885162931,2
    --102630698(+) ACCACA/GCCCAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NGFRAP1 (102631268 - 102633005 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NGFRAP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NGFRAP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300361    OMIM disorders: --

    3 diseases for NGFRAP1:    About MalaCards
    aicardi syndrome    neuronitis    prostatitis


    NGFRAP1 for disorders           About GeneDecksing


    Export disorders for NGFRAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NGFRAP1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with NGFRAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. (PubMed id 10764727)1, 2, 3, 9 Mukai J.... Sato T.-A. (J. Biol. Chem. 2000)
    2. Characterization of three abundant mRNAs from human ovarian granulosa cells. (PubMed id 2171551)1, 2, 3 Rapp G....Scheit K.H. (DNA Cell Biol. 1990)
    3. Characterization of the Bex gene family in humans, mice, and rats. (PubMed id 15958283)1, 2, 9 Alvarez E.... Freed C.R. (Gene 2005)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. (PubMed id 12739005)1, 9 Tong X....Koeffler H.P. (Int. J. Oncol. 2003)
    8. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. (PubMed id 15178455)1, 9 Yoon K....Lee S.Y. (Biochem. Biophys. Res. Commun. 2004)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27018 HGNC: 13388 AceView: NGFRAP1 Ensembl:ENSG00000166681 euGenes: HUgn27018
    ECgene: NGFRAP1 Kegg: 27018 H-InvDB: NGFRAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NGFRAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NGFRAP1 gene:
    Search GeneIP for patents involving NGFRAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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