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Aliases for NGFR Gene

Aliases for NGFR Gene

  • Nerve Growth Factor Receptor 2 3
  • TNFRSF16 3 4 6
  • Low Affinity Nerve Growth Factor Receptor 2 3
  • Low Affinity Neurotrophin Receptor P75NTR 3 4
  • Low-Affinity Nerve Growth Factor Receptor 3 4
  • NGF Receptor 3 4
  • Gp80-LNGFR 3 4
  • P75 ICD 3 4
  • Nerve Growth Factor Receptor (TNFR Superfamily, Member 16) 2
  • Tumor Necrosis Factor Receptor Superfamily Member 16 3
  • TNFR Superfamily, Member 16 3
  • TNFR Superfamily 2
  • CD271 Antigen 4
  • Member 16 2
  • P75(NTR) 3
  • P75NTR 3
  • CD271 3

External Ids for NGFR Gene

Summaries for NGFR Gene

Entrez Gene Summary for NGFR Gene

  • Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGFR Gene

NGFR (Nerve Growth Factor Receptor) is a Protein Coding gene. Diseases associated with NGFR include prurigo nodularis and noma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include signal transducer activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for NGFR Gene

  • Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Tocris Summary for NGFR Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGFR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGFR Gene

Genomics for NGFR Gene

Genomic Location for NGFR Gene

Start:
49,495,293 bp from pter
End:
49,515,020 bp from pter
Size:
19,728 bases
Orientation:
Plus strand

Genomic View for NGFR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGFR Gene

Proteins for NGFR Gene

  • Protein details for NGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08138-TNR16_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 16
    Protein Accession:
    P08138
    Secondary Accessions:
    • B2R961
    • B4E096

    Protein attributes for NGFR Gene

    Size:
    427 amino acids
    Molecular mass:
    45183 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts (via death domain) with RAB31. Interacts with LINGO1 and NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1.

    Three dimensional structures from OCA and Proteopedia for NGFR Gene

    Alternative splice isoforms for NGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGFR Gene

Proteomics data for NGFR Gene at MOPED

Post-translational modifications for NGFR Gene

Other Protein References for NGFR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NGFR Gene

Domains for NGFR Gene

Gene Families for NGFR Gene

HGNC:
  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily
IUPHAR :

UniProtKB/Swiss-Prot:

TNR16_HUMAN
Domain:
  • Death domain is responsible for interaction with RANBP9:
    • P08138
  • The extracellular domain is responsible for interaction with NTRK1.:
    • P08138
  • Contains 1 death domain.:
    • P08138
Similarity:
  • Contains 4 TNFR-Cys repeats.:
    • P08138
genes like me logo Genes that share domains with NGFR: view

Function for NGFR Gene

Molecular function for NGFR Gene

GENATLAS Biochemistry: nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR superfamily,member 16),see also NTRK1
UniProtKB/Swiss-Prot Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Gene Ontology (GO) - Molecular Function for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 3022937
GO:0004872 receptor activity TAS 3022937
GO:0004888 transmembrane signaling receptor activity TAS 1846035
GO:0005035 death receptor activity IEA --
GO:0005515 protein binding IPI 11756426
genes like me logo Genes that share ontologies with NGFR: view
genes like me logo Genes that share phenotypes with NGFR: view

Animal Models for NGFR Gene

MGI Knock Outs for NGFR:

miRNA for NGFR Gene

miRTarBase miRNAs that target NGFR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NGFR Gene

Localization for NGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGFR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGFR Gene COMPARTMENTS Subcellular localization image for NGFR gene
Compartment Confidence
cytosol 4
endosome 4
extracellular 4
nucleus 4
plasma membrane 4
cytoskeleton 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005768 endosome TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NGFR: view

Pathways for NGFR Gene

genes like me logo Genes that share pathways with NGFR: view

Gene Ontology (GO) - Biological Process for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport ISS --
GO:0007165 signal transduction --
GO:0007411 axon guidance IEA --
GO:0007417 central nervous system development IEA --
GO:0010468 regulation of gene expression --
genes like me logo Genes that share ontologies with NGFR: view

Compounds for NGFR Gene

(5) Tocris Compounds for NGFR Gene

Compound Action Cas Number
7,8-Dihydroxyflavone TrkB agonist [38183-03-8]
ANA 12 TrkB receptor antagonist [219766-25-3]
BDNF (human) Activates TrkB and p75 receptors [218441-99-7]
GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
TLQP 21 VGF-derived peptide [869988-94-3]

(4) IUPHAR Ligand for NGFR Gene

Ligand Type Action Affinity Pubmed IDs
neurotrophin-3 None None
neurotrophin-4 None None
NGF None None
BDNF None None

(64) Novoseek inferred chemical compound relationships for NGFR Gene

Compound -log(P) Hits PubMed IDs
k252a 72.2 3
tyrosine 68.6 72
choline 46.3 15
ceramide 41.3 13
acetyl-l-carnitine 36.9 6
genes like me logo Genes that share compounds with NGFR: view

Transcripts for NGFR Gene

mRNA/cDNA for NGFR Gene

Unigene Clusters for NGFR Gene

Nerve growth factor receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NGFR Gene

No ASD Table

Relevant External Links for NGFR Gene

GeneLoc Exon Structure for
NGFR
ECgene alternative splicing isoforms for
NGFR

Expression for NGFR Gene

mRNA expression in normal human tissues for NGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NGFR Gene

This gene is overexpressed in Nerve - Tibial (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NGFR Gene

SOURCE GeneReport for Unigene cluster for NGFR Gene Hs.415768

genes like me logo Genes that share expressions with NGFR: view

Orthologs for NGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGFR 36
  • 99.45 (n)
  • 99.53 (a)
NGFR 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NGFR 36
  • 92.51 (n)
  • 96.02 (a)
NGFR 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGFR 36
  • 92.58 (n)
  • 96.41 (a)
NGFR 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngfr 36
  • 87.84 (n)
  • 92.89 (a)
Ngfr 16
Ngfr 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NGFR 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGFR 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngfr 36
  • 86.73 (n)
  • 92.89 (a)
chicken
(Gallus gallus)
Aves NGFR 36
  • 75.83 (n)
  • 72.77 (a)
NGFR 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGFR 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia p75NTRa 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493992 36
  • 60.33 (n)
  • 59.64 (a)
zebrafish
(Danio rerio)
Actinopterygii NGFR (2 of 3) 37
  • 47 (a)
OneToMany
ngfrb 36
  • 58.82 (n)
  • 52.94 (a)
ngfrb 37
  • 49 (a)
OneToMany
ngfrb 37
  • 45 (a)
OneToMany
Species with no ortholog for NGFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGFR Gene

ENSEMBL:
Gene Tree for NGFR (if available)
TreeFam:
Gene Tree for NGFR (if available)

Paralogs for NGFR Gene

No data available for Paralogs for NGFR Gene

Variants for NGFR Gene

Sequence variations from dbSNP and Humsavar for NGFR Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs558481 -- 49,499,729(+) ACTAC(A/G)GGCGC intron-variant
rs563205 -- 49,500,257(+) ATGAG(A/G)GCAGC intron-variant
rs565042 -- 49,500,477(+) CAGAC(A/G)AAAGC intron-variant
rs575791 -- 49,497,393(+) AGCGT(A/G)GACCA intron-variant
rs600120 -- 49,500,122(+) AACAA(A/G)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NGFR Gene

Variant ID Type Subtype PubMed ID
nsv833473 CNV Gain+Loss 17160897
nsv908585 CNV Loss 21882294

Relevant External Links for NGFR Gene

HapMap Linkage Disequilibrium report
NGFR
Human Gene Mutation Database (HGMD)
NGFR

Disorders for NGFR Gene

(4) University of Copenhagen DISEASES for NGFR Gene

(95) Novoseek inferred disease relationships for NGFR Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 53.7 36
pheochromocytoma 48 4
prurigo nodularis 47.1 3
fibroma shope 45.1 1
tumors 42.1 123

Relevant External Links for NGFR

Genetic Association Database (GAD)
NGFR
Human Genome Epidemiology (HuGE) Navigator
NGFR
genes like me logo Genes that share disorders with NGFR: view

No data available for UniProtKB/Swiss-Prot for NGFR Gene

Publications for NGFR Gene

  1. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PMID: 10514511) Ye X. … Bredesen D.E. (J. Biol. Chem. 1999) 3 4 23
  2. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PMID: 10544233) Irie S. … Sato T.A. (FEBS Lett. 1999) 3 4 23
  3. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PMID: 18780967) Cozza A. … Pellegrini S. (J. Alzheimers Dis. 2008) 3 23 49
  4. Expression and structure of the human NGF receptor. (PMID: 3022937) Johnson D. … Chao M. (Cell 1986) 2 3 4
  5. Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease? (PMID: 16893414) Coulson E.J. (J. Neurochem. 2006) 3 23

Products for NGFR Gene

  • Addgene plasmids for NGFR

Sources for NGFR Gene

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