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Aliases for NGFR Gene

Aliases for NGFR Gene

  • Nerve Growth Factor Receptor 2 3 5
  • Low Affinity Neurotrophin Receptor P75NTR 3 4
  • Low-Affinity Nerve Growth Factor Receptor 3 4
  • TNFR Superfamily, Member 16 2 3
  • NGF Receptor 3 4
  • Gp80-LNGFR 3 4
  • TNFRSF16 3 4
  • P75 ICD 3 4
  • Nerve Growth Factor Receptor (TNFR Superfamily, Member 16) 2
  • Tumor Necrosis Factor Receptor Superfamily Member 16 3
  • Low Affinity Nerve Growth Factor Receptor 2
  • CD271 Antigen 4
  • P75(NTR) 3
  • P75NTR 3
  • CD271 3

External Ids for NGFR Gene

Previous GeneCards Identifiers for NGFR Gene

  • GC17P047283
  • GC17P050052
  • GC17P047914
  • GC17P048047
  • GC17P044927
  • GC17P047572
  • GC17P042937

Summaries for NGFR Gene

Entrez Gene Summary for NGFR Gene

  • Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGFR Gene

NGFR (Nerve Growth Factor Receptor) is a Protein Coding gene. Diseases associated with NGFR include Infiltrative Basal Cell Carcinoma and Prurigo Nodularis. Among its related pathways are p75 NTR receptor-mediated signalling and Phospholipase-C Pathway. GO annotations related to this gene include signal transducer activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for NGFR Gene

  • Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Tocris Summary for NGFR Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.

Gene Wiki entry for NGFR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGFR Gene

Genomics for NGFR Gene

Regulatory Elements for NGFR Gene

Enhancers for NGFR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F049519 1.1 Ensembl ENCODE 17.5 +26.0 25968 3.7 GATA3 SMARCA4 POLR2A IKZF1 REST RAD21 NGFR PHB ENSG00000250186 RPL21P124 LOC100288866 NXPH3 ENSG00000248172 DLX3 MIR6165
GH17F049469 0.9 Ensembl ENCODE 12.8 -24.4 -24381 2.3 KLF1 ZBTB33 ZIC2 NGFR PHB ENSG00000250186 RPL21P124 ENSG00000248172 DLX3 LINC02075
GH17F049453 0.8 Ensembl ENCODE 11.8 -40.9 -40939 1.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A GLIS2 SP3 SP5 TBX21 GLIS1 ENSG00000207127 PHB NGFR RPL21P124 ENSG00000250186 SPOP DLX3 ENSG00000248172 LINC02075 EIF4EP2
GH17F049438 1.3 Ensembl ENCODE 11.8 -55.8 -55845 2.7 ZNF202 CTCF ZNF362 PKNOX1 BHLHE40 ZNF623 JUND KDM1A FOS SPI1 ENSG00000262837 PHB ENSG00000207127 NGFR RPL21P124 ENSG00000250186 NXPH3 LOC100288866 PHOSPHO1 DLX3
GH17F049435 0.6 ENCODE 11.5 -60.0 -60040 0.2 CTCF MAZ ZNF654 ZNF740 REST RAD21 ZFP69B ZGPAT ZNF692 KLF16 PHB ENSG00000250186 RPL21P124 NGFR LOC100288866 NXPH3 EIF4EP2 LINC02075
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NGFR on UCSC Golden Path with GeneCards custom track

Promoters for NGFR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001807911 107 1201 ZNF76 RAD21 GLIS2 ZNF366 KLF7 ZNF391 SP3 YY2 REST ZNF623
ENSR00001807912 1507 801 CTCF SUZ12 ZNF133 ZIC2 RAD21 HBP1 HIC1 GLIS2 SCRT2 ZNF143

Genomic Location for NGFR Gene

Chromosome:
17
Start:
49,495,293 bp from pter
End:
49,515,020 bp from pter
Size:
19,728 bases
Orientation:
Plus strand

Genomic View for NGFR Gene

Genes around NGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGFR Gene

Proteins for NGFR Gene

  • Protein details for NGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08138-TNR16_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 16
    Protein Accession:
    P08138
    Secondary Accessions:
    • B2R961
    • B4E096

    Protein attributes for NGFR Gene

    Size:
    427 amino acids
    Molecular mass:
    45183 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with RTN4R (By similarity). Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts (via death domain) with RAB31. Interacts with LINGO1 and NRADD. Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1.

    Three dimensional structures from OCA and Proteopedia for NGFR Gene

    Alternative splice isoforms for NGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGFR Gene

Post-translational modifications for NGFR Gene

Other Protein References for NGFR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NGFR Gene

Domains & Families for NGFR Gene

Suggested Antigen Peptide Sequences for NGFR Gene

Graphical View of Domain Structure for InterPro Entry

P08138

UniProtKB/Swiss-Prot:

TNR16_HUMAN :
  • Death domain is responsible for interaction with RANBP9.
  • Contains 4 TNFR-Cys repeats.
Domain:
  • Death domain is responsible for interaction with RANBP9.
  • The extracellular domain is responsible for interaction with NTRK1.
  • Contains 1 death domain.
Similarity:
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with NGFR: view

Function for NGFR Gene

Molecular function for NGFR Gene

GENATLAS Biochemistry:
nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR superfamily,member 16),see also NTRK1
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Gene Ontology (GO) - Molecular Function for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 3022937
GO:0004872 receptor activity TAS 3022937
GO:0004888 transmembrane signaling receptor activity TAS 1846035
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0005515 protein binding IPI 11756426
genes like me logo Genes that share ontologies with NGFR: view
genes like me logo Genes that share phenotypes with NGFR: view

Animal Models for NGFR Gene

MGI Knock Outs for NGFR:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NGFR

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NGFR Gene

Localization for NGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGFR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGFR Gene COMPARTMENTS Subcellular localization image for NGFR gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
nucleus 5
plasma membrane 5
golgi apparatus 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005768 endosome TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NGFR: view

Pathways & Interactions for NGFR Gene

genes like me logo Genes that share pathways with NGFR: view

Pathways by source for NGFR Gene

SIGNOR curated interactions for NGFR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport ISS --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP,TAS --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with NGFR: view

Drugs & Compounds for NGFR Gene

(62) Drugs for NGFR Gene - From: ClinicalTrials, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1113,1113
Aldesleukin Approved Pharma 397
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2829
Mesna Approved Pharma 258
Vidarabine Approved Pharma 512

(33) Additional Compounds for NGFR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
HIOC
314054-36-9

(5) Tocris Compounds for NGFR Gene

Compound Action Cas Number
ANA 12 TrkB receptor antagonist 219766-25-3
BDNF (human) Activates TrkB and p75 receptors 218441-99-7
Cyclotraxin B TrkB receptor antagonist 1203586-72-4
HIOC Selective TrkB receptor agonist; neuroprotectant 314054-36-9
LM 22A4 Potent TrkB agonist 37988-18-4
genes like me logo Genes that share compounds with NGFR: view

Transcripts for NGFR Gene

mRNA/cDNA for NGFR Gene

Unigene Clusters for NGFR Gene

Nerve growth factor receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NGFR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGFR Gene

No ASD Table

Relevant External Links for NGFR Gene

GeneLoc Exon Structure for
NGFR
ECgene alternative splicing isoforms for
NGFR

Expression for NGFR Gene

mRNA expression in normal human tissues for NGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NGFR Gene

This gene is overexpressed in Nerve - Tibial (x9.4).

Protein differential expression in normal tissues from HIPED for NGFR Gene

This gene is overexpressed in Retina (39.4) and Fetal testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NGFR Gene



Protein tissue co-expression partners for NGFR Gene

NURSA nuclear receptor signaling pathways regulating expression of NGFR Gene:

NGFR

SOURCE GeneReport for Unigene cluster for NGFR Gene:

Hs.415768
genes like me logo Genes that share expression patterns with NGFR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NGFR Gene

Orthologs for NGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGFR 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia NGFR 34 35
  • 92.58 (n)
cow
(Bos Taurus)
Mammalia NGFR 34 35
  • 92.51 (n)
mouse
(Mus musculus)
Mammalia Ngfr 34 16 35
  • 87.84 (n)
rat
(Rattus norvegicus)
Mammalia Ngfr 34
  • 86.73 (n)
oppossum
(Monodelphis domestica)
Mammalia NGFR 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGFR 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NGFR 34 35
  • 75.83 (n)
lizard
(Anolis carolinensis)
Reptilia NGFR 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493992 34
  • 60.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia p75NTRa 34
zebrafish
(Danio rerio)
Actinopterygii ngfrb 34 35 35
  • 58.82 (n)
NGFR (2 of 3) 35
  • 47 (a)
OneToMany
Species where no ortholog for NGFR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGFR Gene

ENSEMBL:
Gene Tree for NGFR (if available)
TreeFam:
Gene Tree for NGFR (if available)

Paralogs for NGFR Gene

No data available for Paralogs for NGFR Gene

Variants for NGFR Gene

Sequence variations from dbSNP and Humsavar for NGFR Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1042549 -- 49,514,541(+) CCCCT(A/C)TATTT intron-variant, utr-variant-3-prime
rs10626377 -- 49,507,760(+) AGGCA(-/ATAT)AATAT intron-variant
rs10672288 -- 49,502,870(+) TCCTT(-/CCTT)TCTCT intron-variant
rs11079872 -- 49,511,399(+) tttca(C/T)tcagt intron-variant, downstream-variant-500B
rs111331586 -- 49,514,372(+) AGGAA(C/T)TGACT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NGFR Gene

Variant ID Type Subtype PubMed ID
nsv833473 CNV gain+loss 17160897

Variation tolerance for NGFR Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NGFR Gene

Human Gene Mutation Database (HGMD)
NGFR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGFR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGFR Gene

Disorders for NGFR Gene

MalaCards: The human disease database

(35) MalaCards diseases for NGFR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
infiltrative basal cell carcinoma
  • skin infiltrating basal cell carcinoma
prurigo nodularis
anhidrosis
  • absence of sweating
mucosal melanoma
tetraploidy
  • tetraploidy syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NGFR in MalaCards View complete list of genes associated with diseases

Relevant External Links for NGFR

Genetic Association Database (GAD)
NGFR
Human Genome Epidemiology (HuGE) Navigator
NGFR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NGFR
genes like me logo Genes that share disorders with NGFR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NGFR Gene

Publications for NGFR Gene

  1. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PMID: 18780967) Cozza A. … Pellegrini S. (J. Alzheimers Dis. 2008) 3 22 46 64
  2. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PMID: 10514511) Ye X. … Bredesen D.E. (J. Biol. Chem. 1999) 3 4 22 64
  3. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PMID: 10544233) Irie S. … Sato T.A. (FEBS Lett. 1999) 3 4 22 64
  4. Expression and structure of the human NGF receptor. (PMID: 3022937) Johnson D. … Chao M. (Cell 1986) 2 3 4 64
  5. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. (PMID: 20219210) GratacA^s M. … Estivill X. (J Psychiatr Res 2010) 3 46 64

Products for NGFR Gene

Sources for NGFR Gene

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