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NGFR Gene

protein-coding   GIFtS: 69
GCID: GC17P047572

Nerve Growth Factor Receptor

(Previous names: nerve growth factor receptor (TNFR superfamily, member 16))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nerve Growth Factor Receptor1 2     Nerve Growth Factor Receptor (TNFR Superfamily, Member 16)1
TNFRSF162 3 5     TNFR Superfamily1
Low Affinity Nerve Growth Factor Receptor1 2     CD2712
Low Affinity Neurotrophin Receptor P75NTR2 3     p75(NTR)2
Low-Affinity Nerve Growth Factor Receptor2 3     p75NTR2
Gp80-LNGFR2 3     TNFR Superfamily, Member 162
NGF Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 162
P75 ICD2 3     CD271 Antigen3
Member 161     

External Ids:    HGNC: 78091   Entrez Gene: 48042   Ensembl: ENSG000000643007   OMIM: 1620105   UniProtKB: P081383   

Export aliases for NGFR gene to outside databases

Previous GC identifers: GC17P047283 GC17P050052 GC17P047914 GC17P048047 GC17P044927 GC17P042937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NGFR Gene:
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6
cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane
domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor
binding domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for NGFR Gene:
NGFR (nerve growth factor receptor) is a protein-coding gene. Diseases associated with NGFR include brain medulloblastoma, and prurigo nodularis. GO annotations related to this gene include ubiquitin protein ligase binding and signal transducer activity.

UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138
Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and
skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to
the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF,
BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells

summary for NGFR Gene:
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase
activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling
pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.
p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds
different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is
involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in
neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is
involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by
neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors
with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as
an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGFR (Low-affinity nerve growth factor receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NGFR gene promoter:
         AP-2alpha isoform 3   AP-1   ATF-2   AP-2alpha isoform 4   AP-2alpha isoform 2   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNGFR promoter sequence
   Search Chromatin IP Primers for NGFR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NGFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21-q22   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21-q22

NGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGFR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P047572:  view genomic region     (about GC identifiers)

Start:
47,572,655 bp from pter      End:
47,592,382 bp from pter
Size:
19,728 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 16 precursor  
Size: 427 amino acids; 45183 Da
Subunit: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2,
TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with
BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220
and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to
a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2
receptor. Interacts (via death domain) with RAB31 (By similarity). Interacts with LINGO1
1 PDB 3D structure from and Proteopedia for NGFR:
3EWV (3D)    
Secondary accessions: B2R961

Explore the universe of human proteins at neXtProt for NGFR: NX_P08138

Explore proteomics data for NGFR at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc1
  • Phosphorylated on serine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NGFR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002498.1  
    ENSEMBL proteins: 
     ENSP00000172229   ENSP00000421514   ENSP00000421731  
    Reactome Protein details: P08138

    NGFR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for NGFR
    OriGene Purified Protein for NGFR
    OriGene Protein Over-expression Lysate for NGFR
    OriGene MassSpec for NGFR
    OriGene Custom Protein Services for NGFR
    GenScript Custom Purified and Recombinant Proteins Services for NGFR
    Novus Biologicals NGFR Proteins
    Novus Biologicals NGFR Lysate
    Sino Biological Recombinant Protein for NGFR
    Sino Biological Cell Lysate for NGFR
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NGFR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NGFR
    R&D Systems Antibodies for NGFR (NGF R/TNFRSF16)
    Cell Signaling Technology (CST) Antibodies for NGFR 
    OriGene Antibodies for NGFR
    OriGene Custom Antibody Services for NGFR
    Novus Biologicals NGFR Antibodies
    Abcam antibodies for NGFR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NGFR
    LSBio Antibodies in human, mouse, rat for NGFR

    NGFR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NGFR
    R&D Systems ELISAs for NGFR (NGF R/TNFRSF16)
    GenScript Custom Assay Services for NGFR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: nerve growth factor receptor
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022325 TNFR_16
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry P08138

    ProtoNet protein and cluster: P08138

    2 Blocks protein domains:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region


    UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138
    Domain: Death domain is responsible for interaction with RANBP9
    Domain: The extracellular domain is responsible for interaction with NTRK1 (By similarity)
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    NGFR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR16_HUMAN, P08138
    Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and
    skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to
    the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF,
    BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells

         Genatlas biochemistry entry for NGFR:
    nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR superfamily,member 16),see also
    NTRK1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS3022937
    GO:0004872receptor activity TAS3022937
    GO:0004888transmembrane signaling receptor activity TAS1846035
    GO:0005035death receptor activity IEA--
    GO:0005515protein binding IPI11756426
         
    NGFR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NGFR:
     Increased S DNA content  Increased number of mitotic ce 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ngfr) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    NGFR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NGFR: Ngfrtm1Gdc Ngfrtm1Jae Ngfrtm1.2Vk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NGFR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NGFR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NGFR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NGFR

    miRNA
    Products:
        
    miRTarBase miRNAs that target NGFR:
    hsa-mir-335-5p (MIRT016762)

    Block miRNA regulation of human, mouse, rat NGFR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NGFR (see all 30):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidNGFR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NGFR
    Predesigned siRNA for gene silencing in human, mouse, rat NGFR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NGFR

    Clone
    Products:
         
    OriGene clones in human, mouse for NGFR (see all 6)
    OriGene ORF clones in mouse, rat for NGFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NGFR (NM_002507)
    Sino Biological Human cDNA Clone for NGFR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGFR

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NGFR
    Browse ESI BIO Cell Lines and PureStem Progenitors for NGFR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGFR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR16_HUMAN, P08138: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    extracellular4
    nucleus4
    plasma membrane4
    cytoskeleton2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005768endosome TAS--
    GO:0005829cytosol TAS--

    NGFR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NGFR About   (see all 37)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    4p75(NTR)-mediated signaling
    Ceramide signalling0.00
    p75(NTR)-mediated signaling
    5p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    Regulated proteolysis of p75NTR0.00
    Cell death signalling via NRAGE, NRIF and NADE0.74
    p75NTR recruits signalling complexes0.00
    NRAGE signals death through JNK0.71
    Axonal growth stimulation0.00
    NF-kB is activated and signals survival0.00
    NADE modulates death signalling0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NGFR
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NGFR (see all 47)
        Nuclear Receptor Activation by Vitamin-A
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for NGFR
        Neuroscience

    3 Tocris Bioscience Pathways for NGFR
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    5 GeneGo (Thomson Reuters) Pathways for NGFR
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development Neurotrophin family signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Development MAG-dependent inhibition of neurite outgrowth

    4 BioSystems Pathways for NGFR
        BDNF signaling pathway
    Spinal Cord Injury
    p75(NTR)-mediated signaling
    Neurotrophic factor-mediated Trk receptor signaling

    3 Sino Biological Pathways for NGFR
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    Selected Reactome Pathways for NGFR (see all 11)
        p75NTR recruits signalling complexes
    NRIF signals cell death from the nucleus
    Axonal growth inhibition (RHOA activation)
    p75NTR negatively regulates cell cycle via SC1
    Ceramide signalling


    Selected Kegg Pathways  (Kegg details for NGFR) (see all 6):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Neurotrophin signaling pathway


    NGFR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NGFR (see all 6): 
              Neurotrophins & Receptors in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NGFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NGFR (P081381, 2, 3 ENSP000001722294) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SALL2Q9Y4671, 2, 3, ENSP000003335374EBI-1387782,EBI-8541433 MINT-7012365 MINT-7012311 MINT-7012345 I2D: score=2 STRING: ENSP00000333537
    SMN1Q166372, 3MINT-8271344 I2D: score=2 
    SMN2Q166372, 3MINT-8271344 I2D: score=2 
    APPP050671, 3, ENSP000002849814EBI-1387782,EBI-77613 I2D: score=1 STRING: ENSP00000284981
    ANXA7P200732, 3MINT-8248538 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ISS--
    GO:0007165signal transduction ----
    GO:0007411axon guidance IEA--
    GO:0007417central nervous system development IEA--
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IEA--

    NGFR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NGFR
      Browse compounds at ApexBio 

    Compounds for NGFR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BDNF (human)Activates TrkB and p75 receptors[218441-99-7]
    ANA 12TrkB receptor antagonist[219766-25-3]
    GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
    TLQP 21VGF-derived peptide[869988-94-3]
    7,8-Dihydroxyflavone TrkB agonist[38183-03-8]

    4 IUPHAR Ligands for NGFR (nerve growth factor receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    neurotrophin-3
    NoneNone--
    neurotrophin-4
    NoneNone--
    NGF
    NoneNone--
    BDNF
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for NGFR gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 72.2 3 19428697 (1), 18846424 (1), 19710323 (1)
    tyrosine 68.6 88 12218049 (2), 10386964 (1), 10708759 (1), 11359788 (1) (see all 71)
    choline 46.3 18 7837279 (2), 11738495 (1), 18639597 (1), 1401259 (1) (see all 14)
    ceramide 41.3 16 15264225 (2), 11438587 (2), 15264216 (2), 10398299 (1) (see all 10)
    acetyl-l-carnitine 36.9 9 19263582 (3), 1324679 (2), 18500755 (1)
    phosphotyrosine 31.3 8 8563936 (2), 7541035 (1), 8529673 (1), 7518293 (1)
    phosphatidylinositol 28 4 19457114 (1), 1382475 (1), 17666398 (1), 11312266 (1)
    neocarzinostatin 24.7 3 8363646 (1), 15967538 (1)
    saporin 24.3 1 7738592 (1)
    mastoparan 22.7 4 2172020 (2), 7986806 (2)



    NGFR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NGFR gene: 
    NM_002507.3  

    Unigene Cluster for NGFR:

    Nerve growth factor receptor
    Hs.415768  [show with all ESTs]
    Unigene Representative Sequence: BC050309
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000172229(uc002ioz.4) ENST00000509200 ENST00000504201
    miRNA
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    Block miRNA regulation of human, mouse, rat NGFR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NGFR (see all 30):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidNGFR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NGFR
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NGFR (NM_002507)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGFR
    Primer
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    OriGene qPCR primer pairs and template standards for NGFR
    OriGene qSTAR qPCR primer pairs in human, mouse for NGFR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NGFR
      QuantiTect SYBR Green Assays in human, mouse, rat NGFR
      QuantiFast Probe-based Assays in human, mouse, rat NGFR

    Additional mRNA sequence: 

    AK303278.1 AK313654.1 BC050309.1 M14764.1 

    3 DOTS entries:

    DT.452503  DT.75156349  DT.101968457 

    Selected AceView cDNA sequences (see all 81):

    CA412447 BX111500 BM662493 CD516275 CD514641 BQ718679 BP364215 BM980961 
    AU141128 BQ639556 BU689510 CK299927 NM_002507 AU130851 BQ717136 BP344373 
    BU931631 BQ718171 BV196212 BE905269 AA378573 CD558571 BE221897 W67446 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NGFR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTCCAGAC
    NGFR Expression
    About this image


    NGFR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 11 entries
             Non-myelinating Schwann Cells Peripheral Nerve Domain
             Schwann cells
             Schwann-like cells
     
     Schwann Cells (Nervous System)    fully expand to see all 8 entries
             Schwann cells
             Schwann-like cells
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
             Placenta-derived mesenchymal stem cells
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             HNK1+p75+ neural crest cells
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             Olfactory ensheathing cells
             Dopaminergic neuron-like cells
    NGFR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NGFR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.415768
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NGFR (see all 6): 
              Neurotrophins & Receptors in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NGFR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ngfr1 , 5 nerve growth factor receptor (TNFR superfamily, member more1, 5 87.84(n)1
    92.89(a)1
      11 (59.01 cM)5
    180531  NM_033217.31  NP_150086.21 
     955688185 
    chicken
    (Gallus gallus)
    Aves NGFR1 nerve growth factor receptor 75.83(n)
    72.77(a)
      425805  NM_001146133.1  NP_001139605.1 
    lizard
    (Anolis carolinensis)
    Reptilia NGFR6
    nerve growth factor receptor
    62(a)
    1 ↔ 1
    6(76476817-76538301)
    African clawed frog
    (Xenopus laevis)
    Amphibia p75NTRa2 p75 neurotrophin receptor a-1 72.5(n)    AF172399.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ngfrb1 nerve growth factor receptor b 58.82(n)
    52.94(a)
      564338  NM_001198660.1  NP_001185589.1 


    ENSEMBL Gene Tree for NGFR (if available)
    TreeFam Gene Tree for NGFR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NGFR (see all 232)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443159691,2
    --47570794(+) CCACAA/GTGATG 1 -- us2k10--------
    rs1473662581,2
    --47570890(+) CCCCAC/TGAATG 1 -- us2k10--------
    rs116561431,2
    H--47570905(+) AATTAG/TCTTCA 1 -- us2k10--------
    rs116561911,2
    H--47570942(+) TGCTAG/TCGTGC 1 -- us2k10--------
    rs114661171,2
    C,F--47570963(+) AGCACT/CGTTTT 1 -- us2k15Minor allele frequency- C:0.23NA EU WA 328
    rs1895858221,2
    --47570982(+) TTGTTG/TGTTTG 1 -- us2k10--------
    rs114661181,2
    C,F--47570986(+) TTGTTT/GGTTTT 1 -- us2k1 tfbs36Minor allele frequency- G:0.07NA EU WA CSA 211
    rs1811263831,2
    --47570991(+) TGTTTG/TTTGAG 1 -- us2k10--------
    rs114661191,2
    C--47571063(+) CCTCCG/ACCTCC 1 -- us2k13Minor allele frequency- A:0.01NA EU 88
    rs1844170511,2
    --47571276(+) CAAGCA/GCTCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NGFR (47572655 - 47592382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NGFR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908585CNV Loss21882294
    nsv833473CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): NGFR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NGFR
    DNA2.0 Custom Variant and Variant Library Synthesis for NGFR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162010    OMIM disorders: --

    Selected diseases for NGFR (see all 122):    
    About MalaCards
    brain medulloblastoma    prurigo nodularis    posterior cranial fossa meningioma    thymic epithelial tumor
    epithelioid malignant peripheral nerve sheath tumor    malignant peripheral nerve sheath tumor    pediatric ependymoma    hereditary sensory and autonomic neuropathy type v
    allergic encephalomyelitis    pyloric stenosis    hypertrophic pyloric stenosis    distal muscular dystrophy
    critical limb ischemia    thymic carcinoma    neurilemmoma    ganglioneuroma
    olfactory neuroblastoma    hemangiopericytoma    anhidrosis    adenomyosis

    4 diseases from the University of Copenhagen DISEASES database for NGFR:
    Alzheimer's disease     Neuroblastoma     Melanoma     Anhidrosis

    NGFR for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NGFR gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 53.7 40 1464766 (3), 16816366 (2), 1436650 (2), 17349981 (2) (see all 28)
    pheochromocytoma 48 5 9681467 (1), 7763473 (1), 14673001 (1), 1964090 (1)
    prurigo nodularis 47.1 4 9609137 (2), 11875644 (1)
    fibroma shope 45.1 1 2160731 (1)
    tumors 42.1 163 11857376 (5), 15517907 (5), 11398197 (4), 17603629 (4) (see all 82)
    primitive neuroectodermal tumor pnet 42 4 1648743 (1), 1649553 (1), 7526237 (1)
    medulloblastoma 41.6 24 8437665 (6), 19066726 (4), 16077909 (2), 12588433 (1) (see all 9)
    neurodegenerative diseases 41.5 5 19128208 (1), 17385278 (1), 19774790 (1), 17107602 (1) (see all 5)
    peripheral nerve sheath tumors 39.5 1 1656253 (1)
    necrosis 38.2 39 12673888 (2), 1646845 (1), 9631659 (1), 10483869 (1) (see all 32)

    Genetic Association Database (GAD): NGFR
    Human Genome Epidemiology (HuGE) Navigator: NGFR (20 documents)

    Export disorders for NGFR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NGFR gene, integrated from 10 sources (see all 758):
    (articles sorted by number of sources associating them with NGFR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and structure of the human NGF receptor. (PubMed id 3022937)1, 2, 3 Johnson D.... Chao M. (Cell 1986)
    2. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PubMed id 10514511)1, 2, 9 Ye X....Bredesen D.E. (J. Biol. Chem. 1999)
    3. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PubMed id 10544233)1, 2, 9 Irie S.... Sato T.A. (FEBS Lett. 1999)
    4. Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (PubMed id 18428117)1, 4, 9 Conner A.C....Thome J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    5. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PubMed id 18780967)1, 4, 9 Cozza A....Pellegrini S. (J. Alzheimers Dis. 2008)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. (PubMed id 20219210)1, 4 GratacA^s M....Estivill X. (J Psychiatr Res 2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4804 HGNC: 7809 AceView: NGFR Ensembl:ENSG00000064300 euGenes: HUgn4804
    ECgene: NGFR Kegg: 4804 H-InvDB: NGFR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NGFR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NGFR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NGFR gene:
    Search GeneIP for patents involving NGFR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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