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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NGFR Gene

protein-coding   GIFtS: 67
GCID: GC17P047572

nerve growth factor receptor

(Previous names: nerve growth factor receptor (TNFR superfamily, member...)
 Explore 126 diseases affiliated with
NGFR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NGFR    

Aliases
for NGFR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nerve Growth Factor Receptor1 2     P75 ICD2 3
TNFRSF161 2 3 5     Nerve Growth Factor Receptor (TNFR Superfamily, Member 16)1
CD2711 2     Low Affinity Nerve Growth Factor Receptor2
P75NTR1     P75(NTR)1
Low Affinity Neurotrophin Receptor P75NTR2 3     TNFR Superfamily, Member 162
Low-Affinity Nerve Growth Factor Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 162
Gp80-LNGFR2 3     CD271 Antigen3
NGF Receptor2 3     

External Ids:    HGNC: 78091   Entrez Gene: 48042   Ensembl: ENSG000000643007   OMIM: 1620105   UniProtKB: P081383   

Export aliases for NGFR gene to outside databases

Previous GC identifers: GC17P047283 GC17P050052 GC17P047914 GC17P048047 GC17P044927 GC17P042937


Summaries
for NGFR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NGFR:
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine
residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a
155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138
Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal
muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation
of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and
NT-4. Can mediate cell survival as well as cell death of neural cells

summary for NGFR:
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase
activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling
pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.
p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds
different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is
involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in
neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is
involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by
neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors
with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as
an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGFR (Low-affinity nerve growth factor receptor)


Genomic Views
for NGFR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NGFR gene promoter:
         AP-2alpha isoform 3   AP-1   ATF-2   AP-2alpha isoform 4   AP-2alpha isoform 2   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NGFR promoter sequence
   Search SABiosciences Chromatin IP Primers for NGFR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NGFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21-q22   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21-q22

NGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGFR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P047572:  view genomic region     (about GC identifiers)

Start:
 47,572,655 bp from pter      End:
 47,592,382 bp from pter
Size:
 19,728 bases      Orientation:
 plus strand

Proteins
for NGFR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 16 precursor  
Size: 427 amino acids; 45183 Da
Subunit: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2,
TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1
and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this
complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased
association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor.
Interacts (via death domain) with RAB31 (By similarity). Interacts with LINGO1
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for NGFR:
3EWV (3D)    
Secondary accessions: B2R961

Explore the universe of human proteins at neXtProt for NGFR: NX_P08138

Post-translational modifications:

  • N- and O-glycosylated1
  • O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc1
  • Phosphorylated on serine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08138

    • NGFR Protein expression data from MOPED and PaxDb:    About this image 
    NGFR Protein Expression
    REFSEQ proteins: NP_002498.1  
    ENSEMBL proteins: 
     ENSP00000172229   ENSP00000421514   ENSP00000421731  
    Reactome Protein details: P08138
    Human Recombinant Protein Products for NGFR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NGFR (NGF R/TNFRSF16)
    Enzo Life Sciences proteins for NGFR
    OriGene Purified Protein: NGFR
    OriGene Protein Over-expression Lysate: NGFR
    OriGene Custom Protein Services for NGFR 
    GenScript Custom Purified and Recombinant Proteins Services for NGFR
    Novus Biologicals NGFR Proteins
    Novus Biologicals NGFR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005768endosome TAS--

    NGFR for ontologies           About GeneDecksing



    NGFR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NGFR
    R&D Systems Antibodies for NGFR (NGF R/TNFRSF16)
    Cell Signaling Technology (CST) Antibodies for NGFR 
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    GenScript Custom Superior Antibodies Services for NGFR
    Novus Biologicals NGFR Antibodies
    Abcam antibodies for NGFR 
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    ThermoFisher Antibody for NGFR

    Assay Products for NGFR: 
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    R&D Systems ELISAs for NGFR (NGF R/TNFRSF16)
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for NGFR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NGFR for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR022325 TNFR_16
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry P08138

    ProtoNet protein and cluster: P08138

    2 Blocks protein families:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region


    UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138
    Domain: Death domain is responsible for interaction with RANBP9
    Domain: The extracellular domain is responsible for interaction with NTRK1 (By similarity)
    Similarity: Contains 1 death domain
    Similarity: Contains 4 TNFR-Cys repeats


    Function
    for NGFR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR16_HUMAN, P08138
    Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal
    muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation
    of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and
    NT-4. Can mediate cell survival as well as cell death of neural cells

         Genatlas biochemistry entry for NGFR:
    nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR superfamily,member 16),see also
    NTRK1

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS3022937
    GO:0004872receptor activity TAS3022937
    GO:0004888transmembrane signaling receptor activity TAS1846035
    GO:0005035death receptor activity IEA--
    GO:0005515protein binding IPI--
         
    NGFR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NGFR:
     Increased S DNA content  Increased number of mitotic ce 

         15/21 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ngfr) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    NGFR for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for NGFR: Ngfrtm1Gdc Ngfrtm1Jae Ngfrtm1.2Vk
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NGFR 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NGFR
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate NGFR (see all 30):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmid: NGFR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NGFR (see all 7)
    OriGene shRNA RFP: NGFR
    OriGene siRNA: NGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NGFR
    Sirion Biotech Custom design and validation of potent shRNA sequences against NGFR 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NGFR
    Sirion Biotech Customized adenovirus for overexpression of NGFR 
    Sirion Biotech Customized adenovirus for potent knockdown of NGFR

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NGFR (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NGFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NGFR (NM_002507)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGFR 

    Cell Line
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    Search LifeMap BioReagents cell lines for NGFR
    Sirion Biotech Customized stable knockdown cell line services for NGFR 
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    Sirion Biotech Customized stable overexpressing cell line services for NGFR
    Sirion Biotech Customized inducible overexpressing cell line services for NGFR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGFR


    Pathways & Interactions
    for NGFR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/12 pathways (see all 12)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		Cellular Apoptosis Pathway0.65
    		p53 Mediated Apoptosis0.84
    		ERK5 Signaling0.61
    		Mitochondrial Apoptosis0.73
    		eIF2 Pathway0.60
    		Telomerase Components in Cell Signaling0.72
    		Rac1 Pathway0.58
    2p75NTR signals via NF-kB
    		p75NTR signals via NF-kB1.00
    		TRAF6 is auto-ubiquitinated0.56
    		NF-kB is activated and signals survival0.81
    		NRIF signals cell death from the nucleus0.35
    		p75NTR recruits signalling complexes0.81
    		Regulated proteolysis of p75NTR0.18
    3Development HGF signaling pathway
    		Development_Neurotrophin family signaling0.45
    		Apoptosis and survival Role of CDK5 in neuronal death and survival0.24
    		Development Neurotrophin family signaling0.45
    		Neurotrophin signaling pathway0.20
    		Apoptosis and survival_Role of CDK5 in neuronal death and survival0.24
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Glucocorticoid Receptor Signaling0.27
    		PGC1Alpha Pathway0.33
    		Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for NGFR
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Development Neurotrophin family signaling
    Apoptosis and survival Apoptotic TNF-family pathways
    Development MAG-dependent inhibition of neurite outgrowth

    1 R&D Systems Pathway for NGFR
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    5/47 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NGFR (see all 47)
        Nuclear Receptor Activation by Vitamin-A
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for NGFR
        Neuroscience

    3 Tocris Bioscience Pathways for NGFR
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    5 GeneGo (Thomson Reuters) Pathways for NGFR
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development Neurotrophin family signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for NGFR 
        Neurotrophic factor-mediated Trk receptor signaling
    p75(NTR)-mediated signaling

    5/18        Reactome Pathways for NGFR (see all 18)
        NRIF signals cell death from the nucleus
    Axonal growth inhibition (RHOA activation)
    Cell death signalling via NRAGE, NRIF and NADE
    p75NTR negatively regulates cell cycle via SC1
    p75NTR regulates axonogenesis


    2         Kegg Pathways  (Kegg details for NGFR):
        Cytokine-cytokine receptor interaction
    Neurotrophin signaling pathway


    NGFR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NGFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for NGFR (P081381, 2, 3 ENSP000001722294) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SALL2Q9Y4672, 3, ENSP000003335374MINT-7012365 MINT-7012311 MINT-7012345 I2D: score=2 STRING: ENSP00000333537
    SMN1Q166372, 3MINT-8271344 I2D: score=2 
    SMN2Q166372, 3MINT-8271344 I2D: score=2 
    APPP050671, 3, ENSP000002849814EBI-1387782,EBI-77613 I2D: score=1 STRING: ENSP00000284981
    ANXA7P200732, 3MINT-8248538 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ISS--
    GO:0006915apoptotic process TAS--
    GO:0006917induction of apoptosis IEA--
    GO:0007165signal transduction ----
    GO:0007411axon guidance IEA--

    NGFR for ontologies           About GeneDecksing



    Drugs & Compounds
    for NGFR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NGFR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for NGFR

    Compounds for NGFR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BDNF (human)Activates TrkB and p75 receptors[218441-99-7]
    Ro 08-2750Inhibits NGF binding to p75NTR and TrkA[37854-59-4]
    NTR 368p75NTR fragment; induces apoptosis[197230-90-3]
    10/64 Novoseek chemical compound relationships for NGFR gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 72.2 3 19428697 (1), 18846424 (1), 19710323 (1)
    tyrosine 68.6 88 12218049 (2), 10386964 (1), 10708759 (1), 11359788 (1) (see all 71)
    choline 46.3 18 7837279 (2), 11738495 (1), 18639597 (1), 1401259 (1) (see all 14)
    ceramide 41.3 16 15264225 (2), 11438587 (2), 15264216 (2), 10398299 (1) (see all 10)
    acetyl-l-carnitine 36.9 9 19263582 (3), 1324679 (2), 18500755 (1)
    phosphotyrosine 31.3 8 8563936 (2), 7541035 (1), 8529673 (1), 7518293 (1)
    phosphatidylinositol 28 4 19457114 (1), 1382475 (1), 17666398 (1), 11312266 (1)
    neocarzinostatin 24.7 3 8363646 (1), 15967538 (1)
    saporin 24.3 1 7738592 (1)
    mastoparan 22.7 4 2172020 (2), 7986806 (2)

    Search CenterWatch for drugs/clinical trials and news about NGFR / TNR16 

    Transcripts
    for NGFR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NGFR gene: 
    NM_002507.3  

    Unigene Clusters for NGFR:

    Nerve growth factor receptor
    Hs.415768  [show with all ESTs], Hs.681726  [show with all ESTs]
    Unigene Representative Sequences: BC050309, AK125088
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000172229(uc002ioz.4) ENST00000509200 ENST00000504201

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NGFR
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate NGFR (see all 30):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmid: NGFR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NGFR (see all 7)
    OriGene shRNA RFP: NGFR
    OriGene siRNA: NGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NGFR
    Sirion Biotech Custom design and validation of potent shRNA sequences against NGFR 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NGFR (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NGFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NGFR (NM_002507)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGFR 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NGFR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NGFR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NGFR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NGFR

    Additional cDNA sequence: 

    AK125088.1 BC052797.1 

    3 DOTS entries:

    DT.452503  DT.101968457  DT.75156349 

    24/81 AceView cDNA sequences (see all 81):

    CD516275 BQ718679 CD514641 BU689510 BX111500 CK299927 BP364215 AU141128 
    BM662493 BM980961 BQ639556 CA412447 BU854788 M14764 BM666448 NM_002507 
    BU845633 AA377931 BU931390 BV196211 BM695278 BQ636044 BU179207 AA977600 

    GeneLoc Exon Structure


    Expression
    for NGFR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NGFR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTCCAGAC
    NGFR Expression
    About this image

    NGFR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    TestisTestis CordDeveloping Peritubular Myoid CellsReproductive System
    LiverMesoblastic Supporting StromaPre-stellate CellsLiver
    LiverMesoblastic Supporting StromaSubmesothelial CellsLiver
    LiverSinusoidsFetal Hepatic Stellate CellsLiver
    LiverSinusoidsHepatic Stellate CellsLiver
    LiverSinusoidsPericytesLiver, Pericytes
    LungRespiratory BronchiolesBasal CellsLung
    LungTracheaBasal CellsLung
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Mature airway epithelial cells (Directed differentia...)
    HNK1+p75+ cells (Derivation of neural...)
    Neural rosettes (Derivation of neural...)
    HNK1+p75+ cells (Derivation of neural...)
    Neural crest-like cells (Directed differentia...)

    See NGFR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NGFR

    SOURCE GeneReport for Unigene clusters: Hs.415768 Hs.681726
        SABiosciences Expression via Pathway-Focused PCR Arrays including NGFR (see all 6): 
              Neurotrophins & Receptors in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NGFR
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGFR

    Orthologs
    for NGFR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NGFR gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NGFR1 nerve growth factor receptor (TNFR superfamily, member more 74.9(n)
    71.88(a)    		   425805  NM_001146133.1  NP_001139605.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NGFR6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 6(76498964-76538301)
    African clawed frog
    (Xenopus laevis)    		 Amphibia p75NTRa2 p75 neurotrophin receptor a-1 72.5(n)    AF172399.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005372041 tumor necrosis factor receptor superfamily member 16-like 57.39(n)
    52.88(a)    		   100537204  XM_003199576.1  XP_003199624.1 


    ENSEMBL Gene Tree for NGFR (if available)
    TreeFam Gene Tree for NGFR (if available) 

    Paralogs
    for NGFR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NGFR gene
    TNFRSF212  TNFRSF6B2  CD402  TNFRSF1B2  TNFRSF42  TNFRSF11A2  TNFRSF142  TNFRSF11B2  
    LTBR2  TNFRSF92  

    NGFR for paralogs           About GeneDecksing



    Genomic Variants
    for NGFR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/389 NCBI SNPs in NGFR are shown (see all 389)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116545581,2
    		H--42947569(+) CCTCAG/TTTTCC 1 -- ds50014Minor allele frequency- T:0.00NS EA 416
    rs1137441391,2
    		--42947716(+) CAGAGT/CTCCCC 1 -- ds50012Minor allele frequency- C:0.06CSA WA 120
    rs114661341,2
    		C,F--42948004(+) AGAGCC/AAGCTC 1 -- ds50014Minor allele frequency- A:0.05NA EU 212
    rs1145326571,2
    		C,F--42948369(+) ACTTAG/ACGGCA 1 -- nc-transcript-variant1Minor allele frequency- A:0.03WA 118
    rs114661351,2
    		C--42948370(+) CTTAGC/TGGCAC 1 -- nc-transcript-variant4Minor allele frequency- T:0.02NA EU WA 212
    rs748928651,2
    		C,F--42948427(+) AGCCTG/AGAGGA 1 -- nc-transcript-variant3Minor allele frequency- A:0.13CSA EA 124
    rs114661371,2
    		C,F--42948435(+) GGATGC/TGGCTC 1 -- nc-transcript-variant4Minor allele frequency- T:0.06NA EU WA 212
    rs792223441,2
    		--42949196(+) TTCCCC/GATCCT 1 -- int14Minor allele frequency- G:0.11CSA WA EA 240
    rs746727251,2
    		F--42949330(+) CTTCCC/TGCTAG 1 -- int11Minor allele frequency- T:0.09NA 120
    rs114661381,2
    		C,F--42949660(+) GCCCTG/ATCTAG 1 -- int16Minor allele frequency- A:0.05NA EU WA 212

    HapMap Linkage Disequilibrium report for NGFR (47572655 - 47592382 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NGFR
         1 CNV: 5016
    Human Gene Mutation Database (HGMD): NGFR

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NGFR
    DNA2.0 Custom Variant and Variant Library Synthesis for NGFR

    Disorders / Diseases
    for NGFR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NGFR for disorders           About GeneDecksing

    OMIM gene information: 162010    OMIM disorders: --

    20/126 diseases for NGFR (see all 126):    About MalaCards
    malignant peripheral nerve sheath tumor    prurigo nodularis    posterior cranial fossa meningioma    epithelioid malignant peripheral nerve sheath tumor
    hereditary sensory and autonomic neuropathy type v    thyroid carcinoma    spinal cord injury    carcinoma
    attention deficit hyperactivity disorder    primitive neuroectodermal tumor    pyloric stenosis    hypertrophic pyloric stenosis
    dupuytren contracture    amyotrophic lateral sclerosis    thyroiditis    temporal lobe epilepsy
    hereditary sensory neuropathy    autonomic neuropathy    distal muscular dystrophy    allergic rhinitis

    1 disease from the University of Copenhagen DISEASES database for NGFR:
    Alzheimer's disease

    10/95 Novoseek disease relationships for NGFR gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 53.7 40 1464766 (3), 16816366 (2), 1436650 (2), 17349981 (2) (see all 28)
    pheochromocytoma 48 5 9681467 (1), 7763473 (1), 14673001 (1), 1964090 (1)
    prurigo nodularis 47.1 4 9609137 (2), 11875644 (1)
    fibroma shope 45.1 1 2160731 (1)
    tumors 42.1 163 11857376 (5), 15517907 (5), 11398197 (4), 17603629 (4) (see all 82)
    primitive neuroectodermal tumor pnet 42 4 1648743 (1), 1649553 (1), 7526237 (1)
    medulloblastoma 41.6 24 8437665 (6), 19066726 (4), 16077909 (2), 12588433 (1) (see all 9)
    neurodegenerative diseases 41.5 5 19128208 (1), 17385278 (1), 19774790 (1), 17107602 (1) (see all 5)
    peripheral nerve sheath tumors 39.5 1 1656253 (1)
    necrosis 38.2 39 12673888 (2), 1646845 (1), 9631659 (1), 10483869 (1) (see all 32)

    Genetic Association Database (GAD): NGFR
    Human Genome Epidemiology (HuGE) Navigator: NGFR (20 documents)

    Export disorders for NGFR gene to outside databases

    Publications
    for NGFR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NGFR gene, integrated from 9 sources (see all 727):
    (articles sorted by number of sources associating them with NGFR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and structure of the human NGF receptor. (PubMed id 3022937)1, 2, 3 Johnson D.... Chao M. (1986)
    2. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PubMed id 10514511)1, 2, 9 Ye X....Bredesen D.E. (1999)
    3. Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PubMed id 10544233)1, 2, 9 Irie S.... Sato T.A. (1999)
    4. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. (PubMed id 14966521)1, 2 Mi S....Pepinsky R.B. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. (PubMed id 15274039)1, 4 Kunugi H....Kamijima K. (2004)
    7. RanBPM is a novel binding protein for p75NTR. (PubMed id 12963025)1, 2 Bai D.... Huang B.-R. (2003)
    8. The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. (PubMed id 11244088)1, 2 Wooten M.W.... Moscat J. (2001)
    9. Association of the p75 neurotrophin receptor with TRAF6. (PubMed id 9915784)1, 2 Khursigara G.... Chao M.V. (1999)
    10. O-linked oligosaccharide on the 75-kDa neurotrophin receptor. (PubMed id 8627329)1, 2 Chapman B.S.... Lapointe G.R. (1996)

    External Searches for NGFR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NGFR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4804 HGNC: 7809 AceView: NGFR Ensembl:ENSG00000064300 euGenes: HUgn4804
    ECgene: NGFR Kegg: 4804 H-InvDB: NGFR

    Other Databases showing NGFR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NGFR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NGFR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NGFR Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NGFR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NGFR gene:
    Search GeneIP for patents involving NGFR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NGFR gene

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
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