Aliases for NGFR Gene
External Ids for NGFR Gene
Previous GeneCards Identifiers for NGFR Gene
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for NGFR Gene
NGFR (Nerve Growth Factor Receptor) is a Protein Coding gene. Diseases associated with NGFR include Infiltrative Basal Cell Carcinoma and Prurigo Nodularis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75(NTR)-mediated signaling. Gene Ontology (GO) annotations related to this gene include signal transducer activity and transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot for NGFR Gene
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.