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NGFR Gene

protein-coding GIFtS: 71

GC17P044927

nerve growth factor receptor (TNFR superfamily, member 16)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD271 ^¹, ²
Gp80-LNGFR ^², ³
TNFRSF16 ^¹, ², ³, ⁵
p75(NTR) ^²
p75NTR ^¹, ²

Descriptions
CD271 antigen ^³
Low affinity neurotrophin receptor p75NTR ^³
Low-affinity nerve growth factor receptor ^², ³
NGF receptor ^³
low affinity nerve growth factor receptor ^²
nerve growth factor receptor ^²
nerve growth factor receptor (TNFR superfamily, member 16) ^²
p75 ICD ^³

External Ids
HGNC: 7809¹
Entrez Gene: 4804²
UniProtKB: P08138³
Ensembl: ENSG00000064300⁷

Search outside databases for aliases for NGFR gene

Previous GC identifers: GC17P047283 GC17P050052 GC17P047914 GC17P048047

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NGFR:

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats

with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a

single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region

contains the nerve growth factor binding domain. [provided by RefSeq]

UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138

Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell

survival as well as cell death of neural cells

Gene Wiki entry for NGFR (Low_affinity_nerve_growth_factor_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NGFR gene

Entrez Gene cytogenetic band: 17q21-q22 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21-q22

NGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P044927: (about GC identifiers)

Start:	44,927,654 bp from pter
End:	44,947,360 bp from pter
Size:	19,707 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 16 precursor

Size: 427 amino acids; 45183 Da

Subunit: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor.

Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which

bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1.

Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression

levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR

and NTRK1 (By similarity). Interacts with LINGO1

Subcellular location: Membrane; Single-pass type I membrane protein

Post-translational modifications:

N- and O-glycosylated¹

O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc¹

Phosphorylated on serine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002498.1

ENSEMBL proteins:

ENSP00000172229

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for NGFR (NGF R/TNFRSF16)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (p75 NGF Receptor)
	Human Recombinant Proteins from Abnova (NGFR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	3022937
GO:0005887	integral to plasma membrane	TAS	3022937

About this table

Antibodies for NGFR:

	Invitrogen Antibodies for NGFR
	Millipore Mono- and Polyclonal Antibodies for the study of NGFR
	Sigma-Aldrich Antibody Arrays and Antibodies for NGFR
	R&D Systems Antibodies for NGFR (NGF R/TNFRSF16)
	Cell Signaling Technology (CST) Antibodies for NGFR (p75NTR)
	Antibodies from Abcam (p75 NGF Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NGFR)
	Novus Biologicals Antibodies for NGFR

Assays for NGFR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08138

ProtoNet protein and cluster: P08138

2 Blocks protein families:

IPB000488 Death domain

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138

Domain: Death domain is responsible for interaction with RANBP9

Domain: The extracellular domain is responsible for interaction with NTRK1 (By similarity)

Similarity: Contains 1 death domain

Similarity: Contains 4 TNFR-Cys repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NGFR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NGFR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002507

Applied Biosystems Silencer® siRNAs for NGFR

Sigma-Aldrich siRNA and siRNA Panels for NGFR

Sigma-Aldrich shRNA Panels and shRNA for NGFR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NGFR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002507
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002507
untagged cDNA clone in CMV expression vector: NM_002507

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002507

UniProtKB/Swiss-Prot: TNR16_HUMAN, P08138

Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell

survival as well as cell death of neural cells

Genatlas biochemistry entry for NGFR:

nerve growth factor receptor p75,low affinity (tumor necrosis factor receptor,TNFR

superfamily,member 16),see also NTRK1

15/21 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ngfr) (see all 21 ):

	behavior/neurological	craniofacial	digestive/alimentary	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	muscle

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005030	neurotrophin receptor activity	IEA	--
GO:0005035	death receptor activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0048406	nerve growth factor binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/20 Sigma-Aldrich "Your Favorite Gene" Pathways for NGFR (Your Favorite Gene powered by Ingenuity) (see all 20 )

LPS/IL-1 Mediated Inhibition of RXR Function
Neurotrophin/TRK Signaling
Tight Junction Signaling
CDK5 Signaling
Acute Phase Response Signaling

GeneDecks NGFR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NGFR

5/124 Interacting proteins for NGFR (ENSP00000172229³ P08138^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 124 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	P05067¹	STRING (score=.929) EBI-1387782, EBI-77613
SALL2	Q9Y467²	MINT-7012365 MINT-7012311 MINT-7012345
BDNF	ENSP00000320002³	STRING (score=.999)
NDN	ENSP00000332643³	STRING (score=.999)
NGF	ENSP00000358525³	STRING (score=.999)

About this table

5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--
GO:0006917	induction of apoptosis	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007411	axon guidance	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for NGFR

Sigma-Aldrich Small Molecules for NGFR:

Antagonist

Compounds for NGFR available from Tocris Bioscience

Compound	Action	CAS number
BDNF (human)	Activates TrkB and p75 receptors	[218441-99-7]
Ro 08-2750	Inhibits NGF binding to p75NTR and TrkA	[37854-59-4]
NTR 368	p75NTR fragment; induces apoptosis	[197230-90-3]

About this table

10/41 Novoseek chemical compound relationships for NGFR gene (see all 41 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	68.73	81	12218049 (2), 10386964 (1), 10708759 (1), 11359788 (1) (see all 67)
ceramide	42.85	16	15264225 (2), 11438587 (2), 15264216 (2), 10398299 (1) (see all 10)
phosphotyrosine	32.36	8	8563936 (2), 7541035 (1), 8529673 (1), 7518293 (1)
phosphatidylinositol	27.57	3	1382475 (1), 17666398 (1), 11312266 (1)
saporin	25.86	1	7738592 (1)
tellurium	25.16	4	1319505 (2), 7723622 (1)
mastoparan	23.90	4	2172020 (2), 7986806 (2)
dbc-amp	21.74	1	7526237 (1)
estradiol valerate	18.58	3	15941472 (2), 15795180 (1)
matrigel	10.59	3	9487024 (1), 9381967 (1), 8665526 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NGFR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NGFR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002507

Sigma-Aldrich siRNA and siRNA Panels for NGFR

Sigma-Aldrich shRNA Panels and shRNA for NGFR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002507

REFSEQ mRNAs for NGFR gene:

NM_002507.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002507

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002507
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002507
                                 untagged cDNA clone in CMV expression vector: NM_002507

Additional cDNA sequence:

AK125088.1 BC052797.1

3 DOTS entries:

DT.452503 DT.101968457 DT.75156349

24/81 AceView cDNA sequences (see all 81 ):

BU689510 BQ718679 BM662493 CD516275 CK299927 CA412447 BP364215 BM980961

BX111500 AU141128 CD514641 BQ639556 BV196211 CD518230 BU931390 BC050309

BM695278 C04752 BG982676 BV196212 M14764 BU931631 AU130851 CD558571

highest scoring ESTs for NGFR:

M14764 AA378128 AA378259 AA378513 AA378573 AA378883 AA971053 AI143345 AI609803 AI698073

Unigene Clusters for NGFR:

Nerve growth factor receptor (TNFR superfamily, member 16)

Hs.415768 [show with all ESTs], Hs.681726 [show with all ESTs]

Unigene Representative Sequences: BC050309, AK125088

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000172229

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NGFR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NGFR

¹ / ² / ³

3 probe-sets matching NGFR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1673_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	M14764	1.00	1.00	1.00	1
205858_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002507	0.60	1.00	0.82	1
205858_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTTATGAG

SOURCE GeneReport for Unigene clusters: Hs.415768 Hs.681726
Expression variation in blood from EXPOLDB for NGFR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NGFR gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NGFR¹	--	nerve growth factor receptor (TNFR superfamily, member more	92.51(n) 96.3(a)	491071 XM_548191.2 XP_548191.2
chimpanzee (Pan troglodytes)	NGFR¹	--	nerve growth factor receptor (TNFR superfamily, member more	99.45(n) 99.53(a)	455206 XM_511950.2 XP_511950.2
cow (Bos taurus)	NGFR¹	--	nerve growth factor receptor (TNFR superfamily, member more	92.51(n) 96.02(a)	353110 XM_584605.3 XP_584605.3
rat (Rattus norvegicus)	Ngfr¹	--	nerve growth factor receptor (TNFR superfamily, member more	86.81(n) 92.89(a)	24596 NM_012610.1 NP_036742.1
mouse (Mus musculus)	Ngfr^{1, 5}	11 (55.60 cM)⁵	nerve growth factor receptor (TNFR superfamily, member more^{1, 5}	87.84(n)¹ 92.89(a)¹	18053¹ NM_033217.3¹ NP_150086.2¹ AA050723⁵ AA172961⁵ (see all 11)

About this table Species with no ortholog for NGFR

ENSEMBL Gene Tree for NGFR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NGFR gene

TNFRSF11A² LTBR² CD40² TNFRSF4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/174 NCBI SNPs in NGFR are shown (see all 174 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 95)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs741071^1,2	A,C,F,H,O	44946689(+)	`GGTTGC/TGATGA`	1	--	ut3¹		20	EU EA WA NA MN	1746
	rs734194^1,2	C,F,H,O	44946608(+)	`CTGTCT/GTCAAG`	1	--	ut3¹ ese³		14	NA EA MN EU WA	1082
	rs741072^1,2	A,C,F,H	44946702(+)	`AAAAGC/TGGGCC`	1	--	ut3¹		13	EU EA WA NA MN	2500
	rs7219709^1,2	A,C,F,H	44946200(+)	`CTTGCC/TTAGGG`	1	--	ut3¹ ese³		10	EU EA WA NA	648
	rs7224806^1,2	A,C,F,H	44946463(+)	`GAGTTT/CTTTCT`	1	--	ut3¹ trp³		15	EU EA WA NA	1136
	rs741073^1,2	A,C,F,H	44946885(+)	`TTGGAA/GTGAGT`	1	--	ut3¹		19	NA EA MN EU WA	1529
	rs2072446^1,2	C,F,H	44942818(+)	`GGGCTC/TGGACA`	1	S/L	mis¹ ese³		13	EA NA EU WA	2102
--	rs11466124^1,2	C,F,H	44927517(+)	`GGAACC/TGCANG`	1	--	ng5¹		7	NA EU EA WA	506
--	rs3729672^1,2	C,F	44945395(+)	`GCCCCG/ACCCCA`	1	--	ut3¹ ese³		3	NA EU	94
	rs11466171^1,2	F,H	44947033(+)	`CTGTGA/TTGAGG`	1	--	ut3¹		7	NA EU EA WA	502

About this table

HapMap Linkage Disequilibrium images for NGFR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 162010

10/95 Novoseek disease relationships for NGFR gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	52.98	36	1464766 (3), 16816366 (2), 1436650 (2), 17349981 (2) (see all 24)
prurigo nodularis	49.27	4	9609137 (2), 11875644 (1)
pheochromocytoma	48.14	5	9681467 (1), 7763473 (1), 14673001 (1), 1964090 (1)
fibroma shope	46.04	1	2160731 (1)
primitive neuroectodermal tumor pnet	43.76	4	1648743 (1), 1649553 (1), 7526237 (1)
neurodegenerative diseases	42.20	3	19128208 (1), 17385278 (1), 17107602 (1)
tumors	41.86	158	11857376 (5), 15517907 (5), 11398197 (4), 17603629 (4) (see all 78)
peripheral nerve sheath tumors	41.34	1	1656253 (1)
medulloblastoma	40.83	23	8437665 (6), 19066726 (4), 16077909 (2), 12588433 (1) (see all 8)
necrosis	37.63	38	12673888 (2), 1646845 (1), 9631659 (1), 10483869 (1) (see all 31)

About this table

Human Gene Mutation Database: NGFR
Genetic Association Database: NGFR
Human Genome Epidemiology Navigator: NGFR (12 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/612 PubMed articles for NGFR gene (see all 612 ):

Expression and structure of the human NGF receptor. (PubMed id 3022937)^{2, 3, 4} Johnson D.... Chao M. (1986)
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PubMed id 10514511)^{1, 3, 4} Ye X....Bredesen D.E. (1999)
Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. (PubMed id 10544233)^{1, 3, 4} Irie S.... Sato T.A. (1999)
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. (PubMed id 14966521)^{3, 4} Mi S....Pepinsky R.B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. (PubMed id 15274039)^{3, 6} Kunugi H....Kamijima K. (2004)
RanBPM is a novel binding protein for p75NTR. (PubMed id 12963025)^{3, 4} Bai D.... Huang B.-R. (2003)
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. (PubMed id 11244088)^{3, 4} Wooten M.W.... Moscat J. (2001)
Association of the p75 neurotrophin receptor with TRAF6. (PubMed id 9915784)^{3, 4} Khursigara G.... Chao M.V. (1999)
O-linked oligosaccharide on the 75-kDa neurotrophin receptor. (PubMed id 8627329)^{3, 4} Chapman B.S.... Lapointe G.R. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4804	HGNC: 7809	AceView: NGFR	Ensembl:ENSG00000064300	euGenes: HUgn4804
ECgene: NGFR	H-InvDB: NGFR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NGFR	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NGFR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NGFR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NGFR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NGFR		Antibodies for NGFR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NGFR		Small molecules for NGFR
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NGFR)
	Antibodies (NGFR)
	Chimera RNAi (NGFR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for NGFR (p75NTR)

	Recombinant Proteins (p75 NGF Receptor)
	Antibodies (p75 NGF Receptor)

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Tocris compounds for NGFR

	Drugs for NGFR
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Antibodies for NGFR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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NGFR Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for NGFR

Summaries
for NGFR

Genomic Location
for NGFR

Proteins
for NGFR

Protein Domains/
Families
for NGFR

Gene Function
for NGFR

Pathways & Interactions
for NGFR

Drugs & Compounds
for NGFR

Transcripts
for NGFR

Expression
for NGFR

Orthologs
for NGFR

Paralogs
for NGFR

SNPs/Variants
for NGFR

Disorders & Mutations
for NGFR

Medical News
for NGFR

Publications
for NGFR

Search for NGFR

Genome Databases showing NGFR

Other Databases showing NGFR

Specialized Databases showing NGFR

Licensable Technologies
for NGFR

Services
for NGFR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NGFR Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor NGFR

Summariesfor NGFR

Genomic Locationfor NGFR

Proteinsfor NGFR

Protein Domains/Familiesfor NGFR

Gene Functionfor NGFR

Pathways & Interactionsfor NGFR

Drugs & Compoundsfor NGFR

Transcriptsfor NGFR

Expression for NGFR

Orthologsfor NGFR

Paralogsfor NGFR

SNPs/Variantsfor NGFR

Disorders & Mutationsfor NGFR

Medical Newsfor NGFR

Publicationsfor NGFR

Search for NGFR

Genome Databases showing NGFR

Other Databases showing NGFR

Specialized Databases showing NGFR

Licensable Technologiesfor NGFR

Servicesfor NGFR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NGFR

Summaries
for NGFR

Genomic Location
for NGFR

Proteins
for NGFR

Protein Domains/
Families
for NGFR

Gene Function
for NGFR

Pathways & Interactions
for NGFR

Drugs & Compounds
for NGFR

Transcripts
for NGFR

Expression
for NGFR

Orthologs
for NGFR

Paralogs
for NGFR

SNPs/Variants
for NGFR

Disorders & Mutations
for NGFR

Medical News
for NGFR

Publications
for NGFR

Licensable Technologies
for NGFR

Services
for NGFR