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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NGF Gene

protein-coding GIFtS: 69
GCID: GC01M115828

Nerve Growth Factor (Beta Polypeptide)

(Previous symbol: NGFB)

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Nerve Growth Factor (Beta Polypeptide)¹ ²
NGFB¹ ² ³ ⁵
Beta-NGF² ³
HSAN5² ⁵
Beta-Nerve Growth Factor²
Nerve Growth Factor, Beta Subunit²

External Ids:	HGNC: 7808¹	Entrez Gene: 4803²	Ensembl: ENSG00000134259⁷	OMIM: 162030⁵	UniProtKB: P01138³

Export aliases for NGF gene to outside databases

Previous GC identifers: GC01M115630 GC01M113686

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NGF Gene:

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is

incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is

involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons.

Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and

dysregulation of this gene's expression is associated with allergic rhinitis. (provided by RefSeq, Jul 2008)

GeneCards Summary for NGF Gene:

NGF (nerve growth factor (beta polypeptide)) is a protein-coding gene. Diseases associated with NGF include autonomic neuropathy, and cystitis, and among its related super-pathways are Development Neurotrophin family signaling and MAPK signaling pathway. GO annotations related to this gene include nerve growth factor receptor binding and growth factor activity. An important paralog of this gene is NTF4.

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory

nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades

through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

summary for NGF Gene:

Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase

activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling

pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.

p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds

different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is

involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in

neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is

involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by

neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors

with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as

an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGF (Nerve growth factor) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.2 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NGF gene promoter:
AP-2alpha isoform 3 STAT5A AP-2alpha isoform 2 deltaCREB FOXO1a STAT3 AP-2alpha isoform 4 AP-2alpha AP-2alphaA FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NGF promoter sequence

Search SABiosciences Chromatin IP Primers for NGF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1

NGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGF gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M115828: view genomic region (about GC identifiers)

Start:	115,828,537 bp from pter	End:	115,880,857 bp from pter
Size:	52,321 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138 (See protein sequence)

Recommended Name: Beta-nerve growth factor precursor

Size: 241 amino acids; 26959 Da

Subunit: Homodimer

Subcellular location: Secreted

Sequence caution: Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for NGF:

1SG1 (3D)

1WWW (3D)

2IFG (3D)

Secondary accessions: A1A4E5 Q6FHA0 Q96P60 Q9P2Q8 Q9UKL8

Explore the universe of human proteins at neXtProt for NGF: NX_P01138

Explore proteomics data for NGF at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P01138

NGF Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_002497.2

ENSEMBL proteins:

ENSP00000358525

Reactome Protein details: P01138
Human Recombinant Protein Products for NGF:

	EMD Millipore Purified and/or Recombinant NGF Protein
	R&D Systems Recombinant & Natural Proteins for NGF (beta-NGF)
	Enzo Life Sciences proteins for NGF
	OriGene Purified Protein for NGF OriGene Protein Over-expression Lysate for NGF OriGene MassSpec for NGF OriGene Custom Protein Services for NGF
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	Novus Biologicals NGF Proteins Novus Biologicals NGF Lysate
	Sino Biological Recombinant Protein for NGF Sino Biological Cell Lysate for NGF
	ProSpec Recombinant Protein for NGF
	Cloud-Clone Corp. Proteins for NGF

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005768	endosome	TAS	--
GO:0005796	Golgi lumen	TAS	--

NGF for ontologies About GeneDecksing

NGF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NGF
	R&D Systems Antibodies for NGF (beta-NGF)
	Cell Signaling Technology (CST) Antibodies for NGF
	OriGene Antibodies for NGF OriGene Custom Antibody Services for NGF
	GenScript Superior Antibodies for NGF
	Novus Biologicals NGF Antibodies
	Abcam antibodies for NGF
	Cloud-Clone Corp. Antibodies for NGF
	ThermoFisher Antibodies for NGF
	LSBio Antibodies in human, mouse, rat for NGF

Assay Products for NGF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for NGF
	R&D Systems Flow Cytometry Kits for NGF (beta-NGF) (see all)
	GenScript Custom Assay Services for NGF
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for NGF Cloud-Clone Corp. CLIAs for NGF

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5 InterPro protein domains:

IPR020425 Nerve_growth_factor_bsu

IPR020437 Nerve_growth_factor_bsu_mml

IPR002072 Nerve_growth_factor-rel

IPR019846 Nerve_growth_factor_CS

IPR020408 Nerve_growth_factor-like

Graphical View of Domain Structure for InterPro Entry P01138

ProtoNet protein and cluster: P01138

1 Blocks protein domain: IPB002072 Nerve growth factor

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Similarity: Belongs to the NGF-beta family

NGF for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NGF_HUMAN, P01138

Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory

nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades

through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

Summary:

During embryonic development, NGF as signaling molecule

affects the following cells: Pre-Granulosa Cells in Primordial Follicle

NGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Neural induced amniotic-derived mesenchymal stem cells from Spinal Cord, Peripheral sensory neuron-like cells from Neuron (see all).

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005102	receptor binding	--	--
GO:0005163	nerve growth factor receptor binding	IPI	14985763
GO:0008083	growth factor activity	IEA	--

NGF for ontologies About GeneDecksing

Phenotypes:
11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ngf):

behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism	integument
mortality/aging	muscle	nervous system	no phenotypic analysis	normal
vision/eye

NGF for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Ngf^tm1Gne for NGF

inGenious Targeting Laboratory - Custom generated mouse model solutions for NGF

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NGF

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NGF

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NGF

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NGF
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate NGF (see all 12):
		hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: NGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for NGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NGF

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NGF
			Sirion Biotech Customized adenovirus for overexpression of NGF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for NGF (see all 7) OriGene ORF clones in mouse, rat for NGF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NGF (NM_002506)
		Sino Biological Human cDNA Clone for NGF
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGF
		Sirion Biotech Customized lentivirus for stable overexpression of NGF Customized lentivirus expression plasmids for stable overexpression of NGF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NGF
		LifeMap BioReagents: cell lines associated with NGF: PureStem 4D20.8, NCr-fac Progenitor, PureStem E15, Meso-prx/latp Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGF

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for NGF About (see all 31)

See pathways by source

SuperPath

Contained pathways About

Development HGF signaling pathway

	Development Neurotrophin family signaling	0.45			Apoptosis and survival NGF signaling pathway	0.36
	Apoptosis and survival Role of CDK5 in neuronal death and survival	0.37			Neurotrophin signaling pathway	0.36

MAPK signaling pathway

MAPK signaling pathway

0.50

MAPK signaling pathway

0.50

TNF Signaling

Death Receptor Signaling

0.50

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

0.49

ARMS-mediated activation

	Prolonged ERK activation events	0.90			ARMS-mediated activation	0.80
	Frs2-mediated activation	0.90			Signalling to p38 via RIT and RIN	0.72

p75NTR signals via NF-kB

	p75NTR signals via NF-kB	0.81			p75NTR recruits signalling complexes	0.81
	NF-kB is activated and signals survival	0.81			NRIF signals cell death from the nucleus	0.40

Pathways by source See SuperPaths
Show all pathways

5/6 EMD Millipore Pathways for NGF (see all 6)

	Apoptosis and survival NGF signaling pathway
	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Development Neurotrophin family signaling
	Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for NGF

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

1 Cell Signaling Technology (CST) Pathway for NGF

Neuroscience

5/6 GeneGo (Thomson Reuters) Pathways for NGF (see all 6)

	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Development Neurotrophin family signaling
	Apoptosis and survival NGF signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

5/7 BioSystems Pathways for NGF (see all 7)

	MAPK signaling pathway
	SIDS Susceptibility Pathways
	BDNF signaling pathway
	Id Signaling Pathway
	p75(NTR)-mediated signaling

1 Sino Biological Pathway for NGF

Death Receptor Signaling

5/29 Reactome Pathways for NGF (see all 29)

	NRIF signals cell death from the nucleus
	Cell death signalling via NRAGE, NRIF and NADE
	p75NTR negatively regulates cell cycle via SC1
	p75NTR regulates axonogenesis
	Retrograde neurotrophin signalling

4 Kegg Pathways (Kegg details for NGF):

	MAPK signaling pathway
	PI3K-Akt signaling pathway
	Apoptosis
	Neurotrophin signaling pathway

NGF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/90 Interacting proteins for NGF (P01138^{2, 3} ENSP00000358525⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 90)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SORCS3	Q9UPU3²^,³, ENSP00000358715⁴	MINT-56552 MINT-56551 MINT-56550 I2D: score=2 STRING: ENSP00000358715
NGFR	P08138³, ENSP00000172229⁴	I2D: score=4 STRING: ENSP00000172229
MMP7	P09237³, ENSP00000260227⁴	I2D: score=1 STRING: ENSP00000260227
NTRK1	P04629³, ENSP00000351486⁴	I2D: score=5 STRING: ENSP00000351486
SORT1	Q99523³, ENSP00000256637⁴	I2D: score=2 STRING: ENSP00000256637

About this table

Gene Ontology (GO): 45 biological process terms (GO ID links to tree view) (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	TAS	--
GO:0006954	inflammatory response	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	--
GO:0007202	activation of phospholipase C activity	TAS	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007265	Ras protein signal transduction	TAS	--
GO:0007422	peripheral nervous system development	IEA	--
GO:0007613	memory	IEA	--
GO:0008284	positive regulation of cell proliferation	--	--
GO:0008344	adult locomotory behavior	IEA	--
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	14985763
GO:0009314	response to radiation	IEA	--
GO:0009612	response to mechanical stimulus	IEA	--
GO:0010033	response to organic substance	--	--
GO:0010193	response to ozone	IEA	--
GO:0010628	positive regulation of gene expression	IMP	16153003
GO:0014070	response to organic cyclic compound	--	--
GO:0019233	sensory perception of pain	IEA	--
GO:0030307	positive regulation of cell growth	--	--
GO:0031175	neuron projection development	IEA	--
GO:0031954	positive regulation of protein autophosphorylation	IEA	--
GO:0032455	nerve growth factor processing	TAS	--
GO:0032496	response to lipopolysaccharide	IEA	--
GO:0035094	response to nicotine	IEA	--
GO:0042493	response to drug	IEA	--
GO:0043065	positive regulation of apoptotic process	TAS	--
GO:0043066	negative regulation of apoptotic process	TAS	--
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	--
GO:0043434	response to peptide hormone stimulus	IEA	--
GO:0043524	negative regulation of neuron apoptotic process	IEA	--
GO:0045664	regulation of neuron differentiation	--	--
GO:0045666	positive regulation of neuron differentiation	IEA	--
GO:0045773	positive regulation of axon extension	IEA	--
GO:0045786	negative regulation of cell cycle	TAS	--
GO:0046928	regulation of neurotransmitter secretion	IEA	--
GO:0048011	neurotrophin TRK receptor signaling pathway	TAS	--
GO:0048015	phosphatidylinositol-mediated signaling	TAS	--
GO:0050770	regulation of axonogenesis	TAS	--
GO:0050772	positive regulation of axonogenesis	TAS	--
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IEA	--
GO:0051384	response to glucocorticoid stimulus	IEA	--
GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway	IEA	--
GO:0051602	response to electrical stimulus	IEA	--
GO:0097190	apoptotic signaling pathway	TAS	--
GO:2000648	positive regulation of stem cell proliferation	IEA	--

NGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NGF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for NGF available from Tocris Bioscience About this table

Compound	Action	CAS #
BDNF (human)	Activates TrkB and p75 receptors	[218441-99-7]
ANA 12	TrkB receptor antagonist	[219766-25-3]
GNF 5837	Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC	[1033769-28-6]
TLQP 21	VGF-derived peptide	[869988-94-3]
7,8-Dihydroxyflavone	TrkB agonist	[38183-03-8]

1 DrugBank Compound for NGF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Clenbuterol	--	37148-27-9	target	stimulator	10637819 10525174 11146120 11221812 10403429

10/134 Novoseek inferred chemical compound relationships for NGF gene (see all 134) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
k252a	87	67	11997324 (3), 1314657 (2), 14532844 (2), 10595705 (2) (see all 44)
tyrosine	78.8	463	1712104 (5), 1706478 (4), 7815475 (4), 1647176 (3) (see all 99)
cipa	69.8	15	15114061 (3), 18955016 (2), 16138253 (1), 10567924 (1) (see all 9)
dbc-amp	57.7	69	2164566 (4), 19176979 (4), 11572090 (4), 2166778 (4) (see all 27)
propentofylline	57.2	18	8951894 (4), 9621361 (2), 15617731 (1), 9062669 (1) (see all 7)
choline	54.2	36	8294910 (3), 11738495 (2), 2044677 (1), 9168835 (1) (see all 26)
pd 98,059	54	25	11731549 (2), 9012803 (2), 9518660 (2), 10617652 (1) (see all 17)
ly294002	53.1	20	9786998 (2), 11223915 (2), 14614965 (2), 9348296 (1) (see all 15)
phosphatidylinositol	50.5	41	9348296 (3), 10050043 (3), 1382475 (2), 9681989 (2) (see all 25)
cyclic amp	46.9	86	7798916 (5), 15546918 (4), 19176979 (4), 2156018 (4) (see all 26)

1 PharmGKB related drug/compound annotation for NGF gene About this table

Drug/compound	PharmGKB Annotation
methadone	CA

Search CenterWatch for drugs/clinical trials and news about NGF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NGF gene:

NM_002506.2

Unigene Cluster for NGF:

Nerve growth factor (beta polypeptide)

Hs.2561 [show with all ESTs]

Unigene Representative Sequence: BC032517

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369512(uc001efu.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NGF
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate NGF (see all 12):
		hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: NGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for NGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NGF

Clone Products:		OriGene clones in human, mouse for NGF (see all 7) OriGene ORF clones in mouse, rat for NGF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NGF (NM_002506)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGF
		Sirion Biotech Customized lentivirus for stable overexpression of NGF Customized lentivirus expression plasmids for stable overexpression of NGF

Primer Products:		OriGene qPCR primer pairs and template standards for NGF OriGene qSTAR qPCR primer pairs in human, mouse for NGF
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NGF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NGF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NGF

Additional mRNA sequence:

AF411526.1 BC032517.2 BC126148.1 BC126150.1 BT019733.1 CR541855.1 X52599.1

1 DOTS entry:

DT.310657

22 AceView cDNA sequences:

BC032517 CR541855 NM_002506 X52599 BM449450 AF411526 AI700604 BE045524

CD614997 CD614999 BF223074 BE467625 AW770784 CD614995 CD614993 AA610120

AA928118 T52484 AW086159 AI341450 T56316 CD614991

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NGF expression in normal human tissues (normalized intensities) NGF embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTAATTTATA

About this image

NGF expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/19 selected tissues (see all 19) fully expand


Uncategorized (Uncategorized) fully expand to see all 5 entries
PureStem Progenitor E72

Fibroblast
X-gene Foreskin Fibroblasts

Eye (Sensory Organs) fully expand to see all 3 entries
retinal progenitor cell p0

Brain (Nervous System) fully expand to see all 2 entries
Human Cerebellar Astrocytes
optic nerve head astrocytes

Pancreas (Endocrine System) fully expand to see all 2 entries
Duct Cells Pancreatic Ducts
Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

See NGF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NGF

SOURCE GeneReport for Unigene cluster: Hs.2561

SABiosciences Expression via Pathway-Focused PCR Arrays including NGF:

Growth Factors in human mouse rat

Neurotrophins & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

Necrosis in human mouse rat

Synaptic Plasticity in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NGF gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ngf^{1 , 5}	nerve growth factor^{1, 5}	85.56(n)¹ 85.42(a)¹		3 (45.25 cM)⁵ 18049¹ NM_013609.2¹ NP_038637.1¹ 102469928⁵
chicken (Gallus gallus)	Aves	NGF¹	nerve growth factor (beta polypeptide)	71.16(n) 69.13(a)		396466 XM_418016.3 XP_418016.3
lizard (Anolis carolinensis)	Reptilia	NGFB⁶	Nerve growth factor beta polypeptide; Uncharacteri...	54(a)	1 ↔ 1	4(130884200-130884781)
zebrafish (Danio rerio)	Actinopterygii	ntf7²	neurotrophin 7	78.28(n)		30270 AY162427.1

ENSEMBL Gene Tree for NGF (if available)
TreeFam Gene Tree for NGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NGF gene

NTF4² NTF3² BDNF²

3 SIMAP similar genes for NGF using alignment to 1 protein entry: NGF_HUMAN:

NTF3 NTF4 BDNF

NGF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11466112^1,2,4	C,F,H	Hereditary sensory and autonomic neuropathy 5 (HSAN5)⁴ pathogenic¹	115897404(-)	`CCTGGC/TGGTTT`	2	R W	mis¹		12		NA EU NS EA	1144
VAR_068479⁴		--	--	see VAR_068479	2	S N	mis⁴		0	--	--	--	--
rs11584424^1,2	H	--	113734715(+)	`tctttC/Tttttc`	1	--	int¹ trp³		0	--	--	--	--
rs11579114^1,2	H	--	113734716(+)	`ctttcC/Ttttct`	1	--	int¹ trp³		0	--	--	--	--
rs139604780^1,2	C	--	113734717(+)	`TTTCT-/TTTCTTTCT TTCCTTCTTTCTTTCT`	1	--	int¹		0	--	--	--	--
rs7417254^1,2	C,A	--	115846967(+)	`tttttG/Ttattt`	1	--	int¹		0	--	--	--	--
rs370996716^1,2	C	--	115864027(+)	`TTGGG-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs67088159^1,2	C	--	115873352(+)	`GACTT-/CACTC CAAGC`	1	--	int¹		1		CSA	2
rs66486371^1,2	C	--	115873354(+)	`CTTCA-/CTCCA AGCAA`	1	--	int¹		1		NA	2
rs80277383^1,2	C	--	115873356(+)	`TCACTC/TCAAGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NGF (115828537 - 115880857 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for NGF: About this table

Variant ID	Type	Subtype	PubMed ID
nsv159371	CNV	Loss	16902084
esv26121	CNV	Loss	19812545
esv34370	CNV	Gain	17911159
nsv818389	CNV	Gain	17921354
essv21938	CNV	CNV	17122850
essv18166	CNV	CNV	17122850

Human Gene Mutation Database (HGMD): NGF

Locus Specific Mutation Databases (LSDB): NGF

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 162030
OMIM disorders: 608654
UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Hereditary sensory and autonomic neuropathy 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and

autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration

of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients

manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation.

The autonomic involvement is variable. Note=The disease is caused by mutations affecting the gene represented in

this entry

20/182 diseases for NGF (see all 182): About MalaCards

autonomic neuropathy cystitis ependymoblastoma hereditary sensory and autonomic neuropathy type v

corneal ulcer diabetic autonomic neuropathy cannabis abuse chronic cystitis

anhidrosis allergic rhinitis diabetic polyneuropathy askin's tumor

rhinitis keratoconjunctivitis vestibular neuronitis burning mouth syndrome

herpetic keratitis pain disorder diabetic neuropathy phaeochromocytoma

18 diseases from the University of Copenhagen DISEASES database for NGF:

Alzheimer's disease Neuropathy Anhidrosis Toxic encephalopathy

Neuroblastoma Phaeochromocytoma Parkinson's disease Cystitis

Vascular disease Pain disorder Atopic dermatitis Asthma

Amyotrophic lateral sclerosis Eye disease Cholera Diabetes mellitus

Schizophrenia Neuroschistosomiasis

NGF for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/94 Novoseek inferred disease relationships for NGF gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	82.2	131	20155803 (2), 16296925 (2), 1702431 (2), 11288140 (2) (see all 99)
hsan type v	68.9	2	15468048 (1), 19945432 (1)
alzheimers disease	65.9	141	8282080 (5), 10198825 (4), 17404842 (4), 19680822 (4) (see all 92)
neurodegenerative diseases	63.7	35	9829813 (3), 15175980 (2), 2130651 (1), 11263982 (1) (see all 30)
anhidrosis	62.2	11	16138253 (1), 18955016 (1), 10567924 (1), 19201660 (1) (see all 8)
hyperalgesia	58.1	82	7582555 (5), 12958182 (4), 10393882 (3), 18813917 (3) (see all 44)
diabetic neuropathies	53.6	30	2375241 (3), 16528132 (2), 14699981 (2), 2142224 (2) (see all 16)
neurodegeneration	51.9	39	20182028 (3), 16244482 (2), 16815330 (2), 19355851 (2) (see all 25)
sensory neuropathy hereditary	45.2	2	16612677 (1), 10567924 (1)
keratoconjunctivitis vernal	42.8	13	7657550 (6), 10224366 (1), 19844589 (1), 9331280 (1) (see all 6)

Genetic Association Database (GAD): NGF
Human Genome Epidemiology (HuGE) Navigator: NGF (509 documents)

Export disorders for NGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NGF gene, integrated from 9 sources (see all 2082):
(articles sorted by number of sources associating them with NGF)

Utopia: connect your pdf to the dynamic
world of online information

Variation in the BDNF and NGFB genes in German atopic dermatitis patients. (PubMed id 19038326)^{1, 4, 9} Hoffjan S....Stemmler S. (2009)
Crystal structure of nerve growth factor in complex with the ligand- binding domain of the TrkA receptor. (PubMed id 10490030)^{1, 2, 9} Wiesmann C.... de Vos A.M. (1999)
Genomic NGFB variation and multiple sclerosis in a case control study. (PubMed id 19063739)^{1, 4, 9} Akkad D.A....Epplen J.T. (2008)
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. (PubMed id 2025430)^{1, 2, 9} Hallboeoek F.... Persson H. (1991)
SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PubMed id 18780967)^{1, 4, 9} Cozza A....Pellegrini S. (2008)
Association study of 10 genes encoding neurotrophic f actors and their receptors in adult and child attention-deficit/hyperactivity d isorder. (PubMed id 18179783)^{1, 4, 9} RibasAcs M....BayAcs M. (2008)
A novel NGF mutation clarifies the molecular mechanis m and extends the phenotypic spectrum of the HSAN5 neuropathy. (PubMed id 20978020)^{1, 2} Carvalho O.P....Woods C.G. (2011)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (2009)
Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)^{1, 4} Tabakoff B....Hoffman P.L. (2009)
Genes for hereditary sensory and autonomic neuropathi es: a genotype-phenotype correlation. (PubMed id 19651702)^{1, 4} Rotthier A....Timmerman V. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4803	HGNC: 7808	AceView: NGFB	Ensembl:ENSG00000134259	euGenes: HUgn4803
ECgene: NGF	Kegg: 4803	H-InvDB: NGF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NGF	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Nerve_growth_factor

Intellectual Property for NGF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NGF gene:
Search GeneIP for patents involving NGF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Nerve Growth Factor (Beta Polypeptide)

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stable disease
Dementia
Cystitis
Skin Ulcer
Retinoblastoma
Retrograde Degeneration
Dermatitis Atopic
Anhidrosis
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sensory neuropathy
Sensory Disorders
Cannabis Abuse
primary tumor
Sensory Neuropathy Hereditary
Memory impairment
Hyperalgesia
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cell damage
Obstruction
bone marrow metastases
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Tachycardia Ventricular
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effusion
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primitive neuroectodermal tumor PNET
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NGF Gene

Nerve Growth Factor (Beta Polypeptide)

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