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NGF Gene

protein-coding GIFtS: 69
GCID: GC01M115828

Nerve Growth Factor (Beta Polypeptide)

(Previous symbol: NGFB)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Nerve Growth Factor (Beta Polypeptide)¹ ²
NGFB¹ ² ³ ⁵
Beta-NGF² ³
HSAN5² ⁵
Beta-Nerve Growth Factor²
Nerve Growth Factor, Beta Subunit²

External Ids:	HGNC: 7808¹	Entrez Gene: 4803²	Ensembl: ENSG00000134259⁷	OMIM: 162030⁵	UniProtKB: P01138³

Export aliases for NGF gene to outside databases

Previous GC identifers: GC01M115630 GC01M113686

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NGF Gene:

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is

incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is

involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons.

Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and

dysregulation of this gene's expression is associated with allergic rhinitis. (provided by RefSeq, Jul 2008)

GeneCards Summary for NGF Gene:

NGF (nerve growth factor (beta polypeptide)) is a protein-coding gene. Diseases associated with NGF include autonomic neuropathy, and ependymoblastoma. GO annotations related to this gene include nerve growth factor receptor binding and growth factor activity. An important paralog of this gene is NTF4.

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory

nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades

through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

summary for NGF Gene:

Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase

activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling

pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.

p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds

different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is

involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in

neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is

involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by

neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors

with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as

an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGF (Nerve growth factor) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_032977.10 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the NGF gene promoter:
AP-2alpha isoform 3 STAT5A AP-2alpha isoform 2 deltaCREB FOXO1a STAT3 AP-2alpha isoform 4 AP-2alpha AP-2alphaA FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NGF promoter sequence

Search Chromatin IP Primers for NGF

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1

NGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGF gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M115828: view genomic region (about GC identifiers)

Start:	115,828,537 bp from pter	End:	115,880,857 bp from pter
Size:	52,321 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NGF_HUMAN, P01138 (See protein sequence)

Recommended Name: Beta-nerve growth factor precursor

Size: 241 amino acids; 26959 Da

Subunit: Homodimer

Sequence caution: Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for NGF:

1SG1 (3D)

1WWW (3D)

2IFG (3D)

Secondary accessions: A1A4E5 Q6FHA0 Q96P60 Q9P2Q8 Q9UKL8

Explore the universe of human proteins at neXtProt for NGF: NX_P01138

Explore proteomics data for NGF at MOPED

Post-translational modifications:

Glycosylation² at Ser43, Thr46, Asn69, Asn114

Modification sites at PhosphoSitePlus

See NGF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002497.2

ENSEMBL proteins:

ENSP00000358525

Reactome Protein details: P01138

NGF Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant NGF Protein
	R&D Systems Recombinant & Natural Proteins for NGF (beta-NGF)
	Enzo Life Sciences proteins for NGF
	OriGene Purified Proteins for NGF OriGene Protein Over-expression Lysate for NGF OriGene MassSpec for NGF OriGene Custom Protein Services for NGF
	GenScript Custom Purified and Recombinant Proteins Services for NGF
	Novus Biologicals NGF Proteins Novus Biologicals NGF Lysate
	Sino Biological Recombinant Protein for NGF Sino Biological Cell Lysate for NGF
	ProSpec Recombinant Protein for NGF
	Cloud-Clone Corp. Proteins for NGF

NGF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NGF
	R&D Systems Antibodies for NGF (beta-NGF)
	Cell Signaling Technology (CST) Antibodies for NGF
	OriGene Antibodies for NGF OriGene Custom Antibody Services for NGF
	Novus Biologicals NGF Antibodies
	Abcam antibodies for NGF
	Cloud-Clone Corp. Antibodies for NGF
	ThermoFisher Antibodies for NGF
	LSBio Antibodies in human, mouse, rat for NGF

NGF Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for NGF
	R&D Systems Flow Cytometry Kits for NGF (beta-NGF) (see all)
	GenScript Custom Assay Services for NGF
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for NGF Cloud-Clone Corp. CLIAs for NGF

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

5 InterPro protein domains:

IPR020425 Nerve_growth_factor_bsu

IPR020437 Nerve_growth_factor_bsu_mml

IPR002072 Nerve_growth_factor-rel

IPR019846 Nerve_growth_factor_CS

IPR020408 Nerve_growth_factor-like

Graphical View of Domain Structure for InterPro Entry P01138

ProtoNet protein and cluster: P01138

1 Blocks protein domain: IPB002072 Nerve growth factor

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Similarity: Belongs to the NGF-beta family

NGF for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NGF_HUMAN, P01138

Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory

nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades

through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

Summary:

During embryonic development, NGF as signaling molecule affects the following cells:

Ovary: Pre-Granulosa Cells (Primordial Follicle)

NGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
selected tissues (see all 3)

Brain: Neuron-like cells, Neuron-like cells

Spinal Cord: Motor neuron progenitors (Mm), Neural induced amniotic-derived mesenchymal stem cells to see all 2 cells

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005102	receptor binding	--	--
GO:0005163	nerve growth factor receptor binding	IPI	14985763
GO:0008083	growth factor activity	IEA	--

NGF for ontologies About GeneDecksing

Phenotypes:
11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ngf):

behavior/neurological	cardiovascular system	growth/size/body	homeostasis/metabolism	integument
mortality/aging	muscle	nervous system	no phenotypic analysis	normal
vision/eye

NGF for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Ngf^tm1Gne for NGF

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NGF

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NGF

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NGF

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NGF

miRNA Products:		Block miRNA regulation of human, mouse, rat NGF using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate NGF (see all 12):
		hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: NGF 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NGF
		Predesigned siRNA for gene silencing in human, mouse, rat NGF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NGF

Clone Products:		OriGene clones in human, mouse for NGF (see all 6) OriGene ORF clones in mouse, rat for NGF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NGF (NM_002506)
		Sino Biological Human cDNA Clone for NGF
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NGF
		ESI BIO PureStem Progenitors for NGF: PureStem 4D20.8, NCr-fac Progenitor, PureStem E15, Meso-prx/latp Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGF

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NGF_HUMAN, P01138: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
endosome	4
golgi apparatus	4
cytoskeleton	3
nucleus	3
plasma membrane	3
cytosol	2
endoplasmic reticulum	2
mitochondrion	2
lysosome	1
vacuole	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005768	endosome	TAS	--
GO:0005796	Golgi lumen	TAS	--

NGF for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NGF About (see all 26)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Development HGF signaling pathway

	Development Neurotrophin family signaling	0.45			Apoptosis and survival NGF signaling pathway	0.36
	Apoptosis and survival Role of CDK5 in neuronal death and survival	0.37			Neurotrophin signaling pathway	0.36

Neurotrophic factor-mediated Trk receptor signaling

	Neurotrophic factor-mediated Trk receptor signaling			Signalling to STAT3	0.00
	TRKA activation by NGF	0.00

MAPK signaling pathway

MAPK signaling pathway

0.50

MAPK signaling pathway

0.50

TNF Signaling

Death Receptor Signaling

0.50

TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions

0.49

p75(NTR)-mediated signaling

Ceramide signalling

0.00

p75(NTR)-mediated signaling

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for NGF

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NGF (see all 63)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 Cell Signaling Technology (CST) Pathway for NGF

Neuroscience

Selected GeneGo (Thomson Reuters) Pathways for NGF (see all 6)

	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Development Neurotrophin family signaling
	Apoptosis and survival NGF signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

Selected BioSystems Pathways for NGF (see all 7)

	MAPK signaling pathway
	SIDS Susceptibility Pathways
	BDNF signaling pathway
	Id Signaling Pathway
	p75(NTR)-mediated signaling

1 Sino Biological Pathway for NGF

Death Receptor Signaling

Selected Reactome Pathways for NGF (see all 19)

	NRIF signals cell death from the nucleus
	p75NTR negatively regulates cell cycle via SC1
	Retrograde neurotrophin signalling
	NF-kB is activated and signals survival
	PI3K/AKT activation

Selected Kegg Pathways (Kegg details for NGF) (see all 7):

	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	PI3K-Akt signaling pathway
	Apoptosis

NGF for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including NGF:

Growth Factors in human mouse rat

Neurotrophins & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

Necrosis in human mouse rat

Synaptic Plasticity in human mouse rat

Interactions:

GeneGlobe Interaction Network for NGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NGF (P01138^{2, 3} ENSP00000358525⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 102)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SORCS3	Q9UPU3²^,³, ENSP00000358715⁴	MINT-56552 MINT-56551 MINT-56550 I2D: score=2 STRING: ENSP00000358715
NGFR	P08138³, ENSP00000172229⁴	I2D: score=4 STRING: ENSP00000172229
MMP7	P09237³, ENSP00000260227⁴	I2D: score=1 STRING: ENSP00000260227
NTRK1	P04629³, ENSP00000351486⁴	I2D: score=5 STRING: ENSP00000351486
SORT1	Q99523³, ENSP00000256637⁴	I2D: score=2 STRING: ENSP00000256637

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Gene Ontology (GO): 49 biological process terms (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	TAS	--
GO:0006954	inflammatory response	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	--
GO:0007202	activation of phospholipase C activity	TAS	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007265	Ras protein signal transduction	TAS	--
GO:0007422	peripheral nervous system development	IEA	--
GO:0007613	memory	IEA	--
GO:0008284	positive regulation of cell proliferation	--	--
GO:0008344	adult locomotory behavior	IEA	--
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	14985763
GO:0009314	response to radiation	IEA	--
GO:0009612	response to mechanical stimulus	IEA	--
GO:0010033	response to organic substance	--	--
GO:0010193	response to ozone	IEA	--
GO:0010628	positive regulation of gene expression	IMP	16153003
GO:0014070	response to organic cyclic compound	--	--
GO:0019233	sensory perception of pain	IEA	--
GO:0030307	positive regulation of cell growth	--	--
GO:0031175	neuron projection development	--	--
GO:0031954	positive regulation of protein autophosphorylation	IEA	--
GO:0032455	nerve growth factor processing	TAS	--
GO:0032496	response to lipopolysaccharide	IEA	--
GO:0035094	response to nicotine	IEA	--
GO:0042493	response to drug	IEA	--
GO:0043065	positive regulation of apoptotic process	TAS	--
GO:0043066	negative regulation of apoptotic process	TAS	--
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	--
GO:0043434	response to peptide hormone	IEA	--
GO:0043524	negative regulation of neuron apoptotic process	IEA	--
GO:0045664	regulation of neuron differentiation	--	--
GO:0045666	positive regulation of neuron differentiation	IEA	--
GO:0045773	positive regulation of axon extension	IEA	--
GO:0045786	negative regulation of cell cycle	TAS	--
GO:0046928	regulation of neurotransmitter secretion	IEA	--
GO:0048011	neurotrophin TRK receptor signaling pathway	TAS	--
GO:0048015	phosphatidylinositol-mediated signaling	TAS	--
GO:0048812	neuron projection morphogenesis	IDA	17724343
GO:0050770	regulation of axonogenesis	TAS	--
GO:0050772	positive regulation of axonogenesis	TAS	--
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IEA	--
GO:0051384	response to glucocorticoid	IEA	--
GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway	IEA	--
GO:0051402	neuron apoptotic process	IEA	--
GO:0051602	response to electrical stimulus	IEA	--
GO:0097190	apoptotic signaling pathway	TAS	--
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IEA	--
GO:2000648	positive regulation of stem cell proliferation	IEA	--
GO:2000675	negative regulation of type B pancreatic cell apoptotic process	IEA	--

NGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for NGF available from Tocris Bioscience About this table

Compound	Action	CAS #
BDNF (human)	Activates TrkB and p75 receptors	[218441-99-7]
ANA 12	TrkB receptor antagonist	[219766-25-3]
GNF 5837	Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC	[1033769-28-6]
TLQP 21	VGF-derived peptide	[869988-94-3]
7,8-Dihydroxyflavone	TrkB agonist	[38183-03-8]

1 DrugBank Compound for NGF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Clenbuterol	--	37148-27-9	target	stimulator	10637819 10525174 11146120 11221812 10403429

Selected Novoseek inferred chemical compound relationships for NGF gene (see all 134) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
k252a	87	67	11997324 (3), 1314657 (2), 14532844 (2), 10595705 (2) (see all 44)
tyrosine	78.8	463	1712104 (5), 1706478 (4), 7815475 (4), 1647176 (3) (see all 99)
cipa	69.8	15	15114061 (3), 18955016 (2), 16138253 (1), 10567924 (1) (see all 9)
dbc-amp	57.7	69	2164566 (4), 19176979 (4), 11572090 (4), 2166778 (4) (see all 27)
propentofylline	57.2	18	8951894 (4), 9621361 (2), 15617731 (1), 9062669 (1) (see all 7)
choline	54.2	36	8294910 (3), 11738495 (2), 2044677 (1), 9168835 (1) (see all 26)
pd 98,059	54	25	11731549 (2), 9012803 (2), 9518660 (2), 10617652 (1) (see all 17)
ly294002	53.1	20	9786998 (2), 11223915 (2), 14614965 (2), 9348296 (1) (see all 15)
phosphatidylinositol	50.5	41	9348296 (3), 10050043 (3), 1382475 (2), 9681989 (2) (see all 25)
cyclic amp	46.9	86	7798916 (5), 15546918 (4), 19176979 (4), 2156018 (4) (see all 26)

1 PharmGKB related drug/compound annotation for NGF gene About this table

Drug/compound	PharmGKB Annotation
methadone	CA

NGF for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NGF gene:

NM_002506.2

Unigene Cluster for NGF:

Nerve growth factor (beta polypeptide)

Hs.2561 [show with all ESTs]

Unigene Representative Sequence: BC032517

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369512(uc001efu.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat NGF using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate NGF (see all 12):
		hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: NGF 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NGF
		Predesigned siRNA for gene silencing in human, mouse, rat NGF

Clone Products:		OriGene clones in human, mouse for NGF (see all 6) OriGene ORF clones in mouse, rat for NGF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NGF (NM_002506)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGF

Primer Products:		OriGene qPCR primer pairs and template standards for NGF OriGene qSTAR qPCR primer pairs in human, mouse for NGF
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NGF
		QuantiTect SYBR Green Assays in human, mouse, rat NGF
		QuantiFast Probe-based Assays in human, mouse, rat NGF

Additional mRNA sequence:

AF411526.1 BC032517.2 BC126148.1 BC126150.1 BT019733.1 CR541855.1 X52599.1

1 DOTS entry:

DT.310657

22 AceView cDNA sequences:

NM_002506 BC032517 X52599 CR541855 CD614999 BM449450 AI700604 AF411526

BF223074 BE045524 CD614997 CD614993 CD614995 BE467625 AW770784 AA610120

AA928118 T52484 T56316 AW086159 AI341450 CD614991

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NGF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTAATTTATA

About this image

NGF expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 17) fully expand


Eye (Sensory Organs) fully expand to see all 7 entries
Limbal Basal Epithelial Cells Limbus Epithelium
Retina
Anterior neural specified EBs

Epithelial Cells
Limbal Basal Epithelial Cells Limbus Epithelium

Brain (Nervous System) fully expand to see all 2 entries
Encapsulated choroid plexus cells (NTCELL)
Astrocyte-like cells

Peripheral Nervous System (Nervous System) fully expand to see all 2 entries
Schwann-like cells

Schwann Cells (Nervous System) fully expand to see all 2 entries
Schwann-like cells

NGF Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NGF Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.2561

Pathway & Disease-focused RT² Profiler PCR Arrays including NGF:

Growth Factors in human mouse rat

Neurotrophins & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

Necrosis in human mouse rat

Synaptic Plasticity in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for NGF OriGene qSTAR qPCR primer pairs in human, mouse for NGF
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NGF gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ngf^{1 , 5}	nerve growth factor^{1, 5}	85.48(n)¹ 85.06(a)¹		3 (45.25 cM)⁵ 18049¹ NM_013609.3¹ NP_038637.1¹ 102469928⁵
chicken (Gallus gallus)	Aves	NGF¹	nerve growth factor (beta polypeptide)	70.23(n) 67.09(a)		396466 XM_004935008.1 XP_004935065.1
lizard (Anolis carolinensis)	Reptilia	NGFB⁶	Nerve growth factor beta polypeptide; Uncharacteri...	56(a)	1 ↔ 1	4(130884200-130884781)
tropical clawed frog (Xenopus tropicalis)	Amphibia	ngf¹	nerve growth factor (beta polypeptide)	69.05(n) 68.3(a)		100170161 NM_001129924.1 NP_001123396.1
zebrafish (Danio rerio)	Actinopterygii	ntf7²	neurotrophin 7	78.28(n)		30270 AY162427.1

ENSEMBL Gene Tree for NGF (if available)
TreeFam Gene Tree for NGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NGF gene

NTF4² NTF3² BDNF²

3 SIMAP similar genes for NGF using alignment to 1 protein entry: NGF_HUMAN:

NTF3 NTF4 BDNF

NGF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11466112^1,2,,4	C,F,H	Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)⁴ pathogenic¹	115897404(-)	`CCTGGC/TGGTTT`	2	R W	mis¹		12		NA EU NS EA	1144
rs11584424^1,2	H	--	113734715(+)	`tctttC/Tttttc`	1	--	int¹ trp³		0	--	--	--	--
rs11579114^1,2	H	--	113734716(+)	`ctttcC/Ttttct`	1	--	int¹ trp³		0	--	--	--	--
rs139604780^1,2	C	--	113734717(+)	`TTTCT-/TTTCTTTCT TTCCTTCTTTCTTTCT`	1	--	int¹		0	--	--	--	--
rs7417254^1,2	C,A	--	115846967(+)	`tttttG/Ttattt`	1	--	int¹		0	--	--	--	--
rs370996716^1,2	C	--	115864027(+)	`TTGGG-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs67088159^1,2	C	--	115873352(+)	`GACTT-/CACTC CAAGC`	1	--	int¹		1		CSA	2
rs66486371^1,2	C	--	115873354(+)	`CTTCA-/CTCCA AGCAA`	1	--	int¹		1		NA	2
rs80277383^1,2	C	--	115873356(+)	`TCACTC/TCAAGC`	1	--	int¹		0	--	--	--	--
rs72502827^1,2	C	--	115873731(+)	`GGGAA-/GGGGGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NGF (115828537 - 115880857 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for NGF: About this table

Variant ID	Type	Subtype	PubMed ID
nsv159371	CNV	Loss	16902084
esv26121	CNV	Loss	19812545
esv34370	CNV	Gain	17911159
nsv818389	CNV	Gain	17921354
essv21938	CNV	CNV	17122850
essv18166	CNV	CNV	17122850

Human Gene Mutation Database (HGMD): NGF
Locus Specific Mutation Databases (LSDB): NGF

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NGF

DNA2.0 Custom Variant and Variant Library Synthesis for NGF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 162030
OMIM disorders: 608654
UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and

autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration

of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients

manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation.

The autonomic involvement is variable. Note=The disease is caused by mutations affecting the gene represented in

this entry

Selected diseases for NGF (see all 192):
About MalaCards

autonomic neuropathy ependymoblastoma cannabis abuse diabetic autonomic neuropathy

corneal ulcer hereditary sensory and autonomic neuropathy type v cystitis neuroschistosomiasis

chronic cystitis anhidrosis diabetic polyneuropathy burning mouth syndrome

askin's tumor rhinitis diabetic neuropathy vestibular neuronitis

allergic rhinitis cough variant asthma keratoconjunctivitis polyneuropathy

18 diseases from the University of Copenhagen DISEASES database for NGF:

Alzheimer's disease Neuropathy Anhidrosis Toxic encephalopathy

Neuroblastoma Phaeochromocytoma Parkinson's disease Cystitis

Vascular disease Pain disorder Atopic dermatitis Asthma

Amyotrophic lateral sclerosis Eye disease Cholera Diabetes mellitus

Schizophrenia Neuroschistosomiasis

NGF for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for NGF gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	82.2	131	20155803 (2), 16296925 (2), 1702431 (2), 11288140 (2) (see all 99)
hsan type v	68.9	2	15468048 (1), 19945432 (1)
alzheimers disease	65.9	141	8282080 (5), 10198825 (4), 17404842 (4), 19680822 (4) (see all 92)
neurodegenerative diseases	63.7	35	9829813 (3), 15175980 (2), 2130651 (1), 11263982 (1) (see all 30)
anhidrosis	62.2	11	16138253 (1), 18955016 (1), 10567924 (1), 19201660 (1) (see all 8)
hyperalgesia	58.1	82	7582555 (5), 12958182 (4), 10393882 (3), 18813917 (3) (see all 44)
diabetic neuropathies	53.6	30	2375241 (3), 16528132 (2), 14699981 (2), 2142224 (2) (see all 16)
neurodegeneration	51.9	39	20182028 (3), 16244482 (2), 16815330 (2), 19355851 (2) (see all 25)
sensory neuropathy hereditary	45.2	2	16612677 (1), 10567924 (1)
keratoconjunctivitis vernal	42.8	13	7657550 (6), 10224366 (1), 19844589 (1), 9331280 (1) (see all 6)

Genetic Association Database (GAD): NGF
Human Genome Epidemiology (HuGE) Navigator: NGF (509 documents)

Export disorders for NGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NGF gene, integrated from 10 sources (see all 2092):
(articles sorted by number of sources associating them with NGF)

Utopia: connect your pdf to the dynamic
world of online information

Variation in the BDNF and NGFB genes in German atopic dermatitis patients. (PubMed id 19038326)^{1, 4, 9} Hoffjan S....Stemmler S. (Mol. Cell. Probes 2009)
Crystal structure of nerve growth factor in complex with the ligand- binding domain of the TrkA receptor. (PubMed id 10490030)^{1, 2, 9} Wiesmann C.... de Vos A.M. (Nature 1999)
Genomic NGFB variation and multiple sclerosis in a case control study. (PubMed id 19063739)^{1, 4, 9} Akkad D.A....Epplen J.T. (BMC Med. Genet. 2008)
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. (PubMed id 2025430)^{1, 2, 9} Hallboeoek F.... Persson H. (Neuron 1991)
SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PubMed id 18780967)^{1, 4, 9} Cozza A....Pellegrini S. (J. Alzheimers Dis. 2008)
Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. (PubMed id 18179783)^{1, 4, 9} RibasAcs M....BayAcs M. (Biol. Psychiatry 2008)
A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. (PubMed id 20978020)^{1, 2} Carvalho O.P.... Woods C.G. (J. Med. Genet. 2011)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)^{1, 4} Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
Genes for hereditary sensory and autonomic neuropathies: a genotype- phenotype correlation. (PubMed id 19651702)^{1, 4} Rotthier A.... Timmerman V. (Brain 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4803	HGNC: 7808	AceView: NGFB	Ensembl:ENSG00000134259	euGenes: HUgn4803
ECgene: NGF	Kegg: 4803	H-InvDB: NGF

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NGF	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Nerve_growth_factor

Intellectual Property for NGF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NGF gene:
Search GeneIP for patents involving NGF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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NGF Gene

Nerve Growth Factor (Beta Polypeptide)

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stable disease
Dementia
Cystitis
Skin Ulcer
Retinoblastoma
Retrograde Degeneration
Dermatitis Atopic
Anhidrosis
Keratoconjunctivitis Vernal
sensory neuropathy
Sensory Disorders
Cannabis Abuse
primary tumor
Sensory Neuropathy Hereditary
Memory impairment
Hyperalgesia
Allergic rhinitis
cell damage
Obstruction
bone marrow metastases
Infestation
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Tachycardia Ventricular
Follicular Cyst
Corneal Diseases
effusion
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primitive neuroectodermal tumor PNET
Neuroepithelioma
CHRONIC CYSTITIS
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pediatric brain tumor
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NGF Gene

Nerve Growth Factor (Beta Polypeptide)

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