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Aliases for NGF Gene

Aliases for NGF Gene

  • Nerve Growth Factor (Beta Polypeptide) 2 3
  • NGFB 3 4 6
  • Beta-NGF 3 4
  • HSAN5 3 6
  • Nerve Growth Factor, Beta Subunit 3
  • Beta-Nerve Growth Factor 3

External Ids for NGF Gene

Previous Symbols for NGF Gene

  • NGFB

Summaries for NGF Gene

Entrez Gene Summary for NGF Gene

  • This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGF Gene

NGF (Nerve Growth Factor (Beta Polypeptide)) is a Protein Coding gene. Diseases associated with NGF include neuropathy, hereditary sensory and autonomic, type v and neuroschistosomiasis. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include growth factor activity and nerve growth factor receptor binding. An important paralog of this gene is BDNF.

UniProtKB/Swiss-Prot for NGF Gene

  • Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

Tocris Summary for NGF Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGF Gene

Genomics for NGF Gene

Genomic Location for NGF Gene

Start:
115,285,916 bp from pter
End:
115,338,384 bp from pter
Size:
52,469 bases
Orientation:
Minus strand

Genomic View for NGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGF Gene

Proteins for NGF Gene

  • Protein details for NGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01138-NGF_HUMAN
    Recommended name:
    Beta-nerve growth factor
    Protein Accession:
    P01138
    Secondary Accessions:
    • A1A4E5
    • Q6FHA0
    • Q96P60
    • Q9P2Q8
    • Q9UKL8

    Protein attributes for NGF Gene

    Size:
    241 amino acids
    Molecular mass:
    26959 Da
    Quaternary structure:
    • Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.
    SequenceCaution:
    • Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NGF Gene

neXtProt entry for NGF Gene

Proteomics data for NGF Gene at MOPED

Post-translational modifications for NGF Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser43, Thr46, Asn69, and Asn114

Other Protein References for NGF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NGF Gene

Domains for NGF Gene

Gene Families for NGF Gene

HGNC:

Suggested Antigen Peptide Sequences for NGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01138

UniProtKB/Swiss-Prot:

NGF_HUMAN
Family:
  • Belongs to the NGF-beta family.:
    • P01138
genes like me logo Genes that share domains with NGF: view

Function for NGF Gene

Molecular function for NGF Gene

UniProtKB/Swiss-Prot Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

LifeMap Function Summary for NGF Gene

It affects the following cells:
NGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005102 receptor binding --
GO:0005163 nerve growth factor receptor binding IPI 14985763
GO:0005515 protein binding IPI 10490030
GO:0008083 growth factor activity IBA --
genes like me logo Genes that share ontologies with NGF: view
genes like me logo Genes that share phenotypes with NGF: view

Animal Models for NGF Gene

MGI Knock Outs for NGF:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NGF Gene

Localization for NGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGF Gene COMPARTMENTS Subcellular localization image for NGF gene
Compartment Confidence
extracellular 5
endosome 4
golgi apparatus 4
cytoskeleton 3
nucleus 3
plasma membrane 3
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005768 endosome TAS --
GO:0005796 Golgi lumen TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IBA --
genes like me logo Genes that share ontologies with NGF: view

Pathways for NGF Gene

SuperPathways for NGF Gene

genes like me logo Genes that share pathways with NGF: view

Gene Ontology (GO) - Biological Process for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006954 inflammatory response IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with NGF: view

Compounds for NGF Gene

(5) Tocris Compounds for NGF Gene

Compound Action Cas Number
7,8-Dihydroxyflavone TrkB agonist [38183-03-8]
ANA 12 TrkB receptor antagonist [219766-25-3]
BDNF (human) Activates TrkB and p75 receptors [218441-99-7]
GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
TLQP 21 VGF-derived peptide [869988-94-3]

(1) Drugbank Compounds for NGF Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Clenbuterol
37148-27-9 target stimulator

(134) Novoseek inferred chemical compound relationships for NGF Gene

Compound -log(P) Hits PubMed IDs
k252a 87 50
tyrosine 78.8 161
cipa 69.8 12
dbc-amp 57.7 49
propentofylline 57.2 11

(1) PharmGKB related drug/compound annotations for NGF Gene

Drug/compound Annotation
methadone CA
genes like me logo Genes that share compounds with NGF: view

Transcripts for NGF Gene

mRNA/cDNA for NGF Gene

Unigene Clusters for NGF Gene

Nerve growth factor (beta polypeptide):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NGF Gene

No ASD Table

Relevant External Links for NGF Gene

GeneLoc Exon Structure for
NGF
ECgene alternative splicing isoforms for
NGF

Expression for NGF Gene

mRNA expression in normal human tissues for NGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NGF Gene

This gene is overexpressed in Heart - Atrial Appendage (4.7), Ovary (4.6), and Artery - Aorta (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NGF Gene

SOURCE GeneReport for Unigene cluster for NGF Gene Hs.2561

genes like me logo Genes that share expressions with NGF: view

No data available for mRNA Expression by UniProt/SwissProt for NGF Gene

Orthologs for NGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGF 35
  • 99.03 (n)
  • 99.17 (a)
NGF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NGF 35
  • 87.97 (n)
  • 90.87 (a)
NGF 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGF 35
  • 87.41 (n)
  • 90.87 (a)
NGFB 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngf 35
  • 85.48 (n)
  • 85.06 (a)
Ngf 16
Ngf 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NGF 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngf 35
  • 85.62 (n)
  • 85.89 (a)
chicken
(Gallus gallus)
Aves NGF 35
  • 70.23 (n)
  • 67.09 (a)
NGF 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGFB 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngf 35
  • 69.05 (n)
  • 68.3 (a)
zebrafish
(Danio rerio)
Actinopterygii ngf 36
  • 51 (a)
OneToMany
ntf7 35
ntf7 36
  • 44 (a)
OneToMany
Species with no ortholog for NGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGF Gene

ENSEMBL:
Gene Tree for NGF (if available)
TreeFam:
Gene Tree for NGF (if available)

Paralogs for NGF Gene

Paralogs for NGF Gene

Selected SIMAP similar genes for NGF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NGF: view

Variants for NGF Gene

Sequence variations from dbSNP and Humsavar for NGF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6325 -- 115,286,742(-) CAGGC(A/G)GAACC synonymous-codon, reference
rs6326 -- 115,287,840(-) GTGGG(C/G)TAACT intron-variant
rs6327 -- 115,287,365(-) GCTCC(A/G)AGTCA intron-variant
rs6328 -- 115,287,322(-) GAAAG(G/T)GGGTA intron-variant
rs6329 -- 115,287,199(-) GAGAG(A/G)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NGF Gene

Variant ID Type Subtype PubMed ID
esv26121 CNV Loss 19812545
essv18166 CNV CNV 17122850
essv21938 CNV CNV 17122850
esv34370 CNV Gain 17911159
nsv818389 CNV Gain 17921354
nsv159371 CNV Loss 16902084

Relevant External Links for NGF Gene

HapMap Linkage Disequilibrium report
NGF
Human Gene Mutation Database (HGMD)
NGF
Locus Specific Mutation Databases (LSDB)
NGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGF Gene

Disorders for NGF Gene

(1) OMIM Diseases for NGF Gene (162030)

UniProtKB/Swiss-Prot

NGF_HUMAN
  • Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. {ECO:0000269 PubMed:14976160, ECO:0000269 PubMed:22302274}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(94) Novoseek inferred disease relationships for NGF Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 82.2 104
hsan type v 68.9 2
alzheimers disease 65.9 115
neurodegenerative diseases 63.7 33
anhidrosis 62.2 8

Relevant External Links for NGF

Genetic Association Database (GAD)
NGF
Human Genome Epidemiology (HuGE) Navigator
NGF
genes like me logo Genes that share disorders with NGF: view

Publications for NGF Gene

  1. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PMID: 18780967) Cozza A. … Pellegrini S. (J. Alzheimers Dis. 2008) 3 23 48
  2. Variation in the BDNF and NGFB genes in German atopic dermatitis patients. (PMID: 19038326) Hoffjan S. … Stemmler S. (Mol. Cell. Probes 2009) 3 23 48
  3. Genomic NGFB variation and multiple sclerosis in a case control study. (PMID: 19063739) Akkad D.A. … Epplen J.T. (BMC Med. Genet. 2008) 3 23 48
  4. Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI. (PMID: 20164177) Wijeyewickrema L.C. … Andrews R.K. (J. Biol. Chem. 2010) 3 4 23
  5. Nerve growth factor promotes cardiac repair following myocardial infarction. (PMID: 20360245) Meloni M. … Emanueli C. (Circ. Res. 2010) 3 23

Products for NGF Gene

Sources for NGF Gene

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