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NGF Gene

protein-coding   GIFtS: 69
GCID: GC01M115828

Nerve Growth Factor (Beta Polypeptide)


(Previous symbol: NGFB)
  See NGF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nerve Growth Factor (Beta Polypeptide)1 2
NGFB1 2 3 5
Beta-NGF2 3
HSAN52 5
Beta-Nerve Growth Factor2
Nerve Growth Factor, Beta Subunit2

External Ids:    HGNC: 78081   Entrez Gene: 48032   Ensembl: ENSG000001342597   OMIM: 1620305   UniProtKB: P011383   

Export aliases for NGF gene to outside databases

Previous GC identifers: GC01M115630 GC01M113686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NGF Gene:
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is
incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is
involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons.
Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and
dysregulation of this gene's expression is associated with allergic rhinitis. (provided by RefSeq, Jul 2008)

GeneCards Summary for NGF Gene:
NGF (nerve growth factor (beta polypeptide)) is a protein-coding gene. Diseases associated with NGF include ependymoblastoma, and neuroschistosomiasis. GO annotations related to this gene include nerve growth factor receptor binding and growth factor activity. An important paralog of this gene is NTF4.

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138
Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory
nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades
through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

summary for NGF Gene:
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase
activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling
pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.
p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds
different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is
involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in
neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is
involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by
neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors
with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as
an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGF (Nerve growth factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NGF gene promoter:
         AP-2alpha isoform 3   STAT5A   AP-2alpha isoform 2   deltaCREB   FOXO1a   STAT3   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNGF promoter sequence
   Search Chromatin IP Primers for NGF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

NGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M115828:  view genomic region     (about GC identifiers)

Start:
115,828,537 bp from pter      End:
115,880,857 bp from pter
Size:
52,321 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NGF_HUMAN, P01138 (See protein sequence)
Recommended Name: Beta-nerve growth factor precursor  
Size: 241 amino acids; 26959 Da
Subunit: Homodimer
Sequence caution: Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for NGF:
1SG1 (3D)        1WWW (3D)        2IFG (3D)    
Secondary accessions: A1A4E5 Q6FHA0 Q96P60 Q9P2Q8 Q9UKL8

Explore the universe of human proteins at neXtProt for NGF: NX_P01138

Explore proteomics data for NGF at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser43, Thr46, Asn69, Asn114
  • Modification sites at PhosphoSitePlus

  • See NGF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002497.2  
    ENSEMBL proteins: 
     ENSP00000358525  
    Reactome Protein details: P01138

    NGF Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for NGF
    Sino Biological Cell Lysate for NGF
    ProSpec Recombinant Protein for NGF
    Cloud-Clone Corp. Proteins for NGF

     
    Search eBioscience for Proteins for NGF 

    NGF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NGF
    R&D Systems Antibodies for NGF (beta-NGF)
    Cell Signaling Technology (CST) Antibodies for NGF 
    OriGene Antibodies for OriGene Antibodies for NGF (NM_002506  NM_002506  )
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    Novus Biologicals NGF Antibodies
    Abcam antibodies for NGF
    Cloud-Clone Corp. Antibodies for NGF
    ThermoFisher Antibodies for NGF
    LSBio Antibodies in human, mouse, rat for NGF

    NGF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Flow Cytometry Kits for NGF (beta-NGF)         (see all)
    GenScript Custom Assay Services for NGF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NGF
    Cloud-Clone Corp. CLIAs for NGF
    Search eBioscience for ELISAs for NGF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR020425 Nerve_growth_factor_bsu
     IPR020437 Nerve_growth_factor_bsu_mml
     IPR002072 Nerve_growth_factor-rel
     IPR019846 Nerve_growth_factor_CS
     IPR020408 Nerve_growth_factor-like

    Graphical View of Domain Structure for InterPro Entry P01138

    ProtoNet protein and cluster: P01138

    1 Blocks protein domain: IPB002072 Nerve growth factor

    UniProtKB/Swiss-Prot: NGF_HUMAN, P01138
    Similarity: Belongs to the NGF-beta family


    Find genes that share domains with NGF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NGF_HUMAN, P01138
    Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory
    nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades
    through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

         Summary: 

    During embryonic development, NGF as signaling molecule affects the following cells:
    Ovary: Pre-Granulosa Cells (Primordial Follicle)

    NGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 3)      
    Brain: Neuron-like cells, Neuron-like cells
    Spinal Cord: Motor neuron progenitors (Mm), Neural induced amniotic-derived mesenchymal stem cells        to see all 2 cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005102receptor binding ----
    GO:0005163nerve growth factor receptor binding IPI14985763
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with NGF           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ngf):
     behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism  integument 
     mortality/aging  muscle  nervous system  no phenotypic analysis  normal 
     vision/eye 

    Find genes that share phenotypes with NGF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ngftm1Gne for NGF

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NGF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NGF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NGF

    miRNA
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    Block miRNA regulation of human, mouse, rat NGF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NGF (see all 12):
    hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidNGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NGF
    Predesigned siRNA for gene silencing in human, mouse, rat NGF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NGF

    Clone
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    OriGene clones in human, mouse for NGF (see all 6)
    OriGene ORF clones in mouse, rat for NGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NGF (NM_002506)
    Sino Biological Human cDNA Clone for NGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGF

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NGF
    ESI BIO PureStem Progenitors for NGF: 
    PureStem 4D20.8, NCr-fac Progenitor, PureStem E15, Meso-prx/latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NGF_HUMAN, P01138: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endosome4
    golgi apparatus4
    cytoskeleton3
    nucleus3
    plasma membrane3
    cytosol2
    endoplasmic reticulum2
    mitochondrion2
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005768endosome TAS--
    GO:0005796Golgi lumen TAS--

    Find genes that share ontologies with NGF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NGF About   (see all 26)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Neurotrophin signaling pathway0.36
    2Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    Signalling to STAT30.00
    TRKA activation by NGF0.00
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4TNF Signaling
    Death Receptor Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    5p75(NTR)-mediated signaling
    Ceramide signalling0.00
    p75(NTR)-mediated signaling


    Find genes that share SuperPaths with NGF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NGF
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NGF (see all 63)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for NGF
        Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for NGF (see all 6)
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development Neurotrophin family signaling
    Apoptosis and survival NGF signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for NGF (see all 7)
        MAPK signaling pathway
    SIDS Susceptibility Pathways
    BDNF signaling pathway
    Id Signaling Pathway
    p75(NTR)-mediated signaling

    1 Sino Biological Pathway for NGF
        Death Receptor Signaling

    Selected Reactome Pathways for NGF (see all 19)
        NRIF signals cell death from the nucleus
    p75NTR negatively regulates cell cycle via SC1
    Retrograde neurotrophin signalling
    NF-kB is activated and signals survival
    PI3K/AKT activation


    Selected Kegg Pathways  (Kegg details for NGF) (see all 7):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Apoptosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NGF: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NGF (P011382, 3 ENSP000003585254) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SORCS3Q9UPU32, 3, ENSP000003587154MINT-56552 MINT-56551 MINT-56550 I2D: score=2 STRING: ENSP00000358715
    NGFRP081383, ENSP000001722294I2D: score=4 STRING: ENSP00000172229
    MMP7P092373, ENSP000002602274I2D: score=1 STRING: ENSP00000260227
    NTRK1P046293, ENSP000003514864I2D: score=5 STRING: ENSP00000351486
    SORT1Q995233, ENSP000002566374I2D: score=2 STRING: ENSP00000256637
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    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0006954inflammatory response IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS--
    GO:0007202activation of phospholipase C activity TAS--
    GO:0007264small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with NGF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NGF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BDNF (human)Activates TrkB and p75 receptors[218441-99-7]
    ANA 12TrkB receptor antagonist[219766-25-3]
    GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
    TLQP 21VGF-derived peptide[869988-94-3]
    7,8-Dihydroxyflavone TrkB agonist[38183-03-8]

    1 DrugBank Compound for NGF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Clenbuterol-- 37148-27-9targetstimulator10637819 10525174 11146120 11221812 10403429

    Selected Novoseek inferred chemical compound relationships for NGF gene (see all 134)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 87 67 11997324 (3), 1314657 (2), 14532844 (2), 10595705 (2) (see all 44)
    tyrosine 78.8 463 1712104 (5), 1706478 (4), 7815475 (4), 1647176 (3) (see all 99)
    cipa 69.8 15 15114061 (3), 18955016 (2), 16138253 (1), 10567924 (1) (see all 9)
    dbc-amp 57.7 69 2164566 (4), 19176979 (4), 11572090 (4), 2166778 (4) (see all 27)
    propentofylline 57.2 18 8951894 (4), 9621361 (2), 15617731 (1), 9062669 (1) (see all 7)
    choline 54.2 36 8294910 (3), 11738495 (2), 2044677 (1), 9168835 (1) (see all 26)
    pd 98,059 54 25 11731549 (2), 9012803 (2), 9518660 (2), 10617652 (1) (see all 17)
    ly294002 53.1 20 9786998 (2), 11223915 (2), 14614965 (2), 9348296 (1) (see all 15)
    phosphatidylinositol 50.5 41 9348296 (3), 10050043 (3), 1382475 (2), 9681989 (2) (see all 25)
    cyclic amp 46.9 86 7798916 (5), 15546918 (4), 19176979 (4), 2156018 (4) (see all 26)

    1 PharmGKB related drug/compound annotation for NGF gene    About this table
    Drug/compound PharmGKB Annotation
    methadoneCA  



    Find genes that share compounds with NGF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NGF gene: 
    NM_002506.2  

    Unigene Cluster for NGF:

    Nerve growth factor (beta polypeptide)
    Hs.2561  [show with all ESTs]
    Unigene Representative Sequence: BC032517
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369512(uc001efu.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NGF (see all 12):
    hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidNGF 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NGF (NM_002506)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NGF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NGF
      QuantiTect SYBR Green Assays in human, mouse, rat NGF
      QuantiFast Probe-based Assays in human, mouse, rat NGF

    Additional mRNA sequence: 

    AF411526.1 BC032517.2 BC126148.1 BC126150.1 BT019733.1 CR541855.1 X52599.1 

    1 DOTS entry:

    DT.310657 

    22 AceView cDNA sequences:

    NM_002506 BC032517 X52599 CR541855 CD614999 BM449450 AI700604 AF411526 
    BF223074 BE045524 CD614997 CD614993 CD614995 BE467625 AW770784 AA610120 
    AA928118 T52484 T56316 AW086159 AI341450 CD614991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NGF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAATTTATA
    NGF Expression
    About this image


    NGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 7 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
             Retina
             Anterior neural specified EBs
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Encapsulated choroid plexus cells (NTCELL)
             Astrocyte-like cells
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Schwann-like cells
     
     Schwann Cells (Nervous System)    fully expand to see all 2 entries
             Schwann-like cells
    NGF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NGF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2561
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NGF: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NGF gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ngf1 , 5 nerve growth factor1, 5 85.48(n)1
    85.06(a)1
      3 (45.25 cM)5
    180491  NM_013609.31  NP_038637.11 
     1024699285 
    chicken
    (Gallus gallus)
    Aves NGF1 nerve growth factor (beta polypeptide) 70.23(n)
    67.09(a)
      396466  XM_004935008.1  XP_004935065.1 
    lizard
    (Anolis carolinensis)
    Reptilia NGFB6
    Nerve growth factor beta polypeptide; Uncharacteri...
    56(a)
    1 ↔ 1
    4(130884200-130884781)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ngf1 nerve growth factor (beta polypeptide) 69.05(n)
    68.3(a)
      100170161  NM_001129924.1  NP_001123396.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntf72 neurotrophin 7 78.28(n)   30270  AY162427.1 


    ENSEMBL Gene Tree for NGF (if available)
    TreeFam Gene Tree for NGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NGF gene
    NTF42  NTF32  BDNF2  
    3 SIMAP similar genes for NGF using alignment to 1 protein entry:     NGF_HUMAN:
    NTF3    NTF4    BDNF

    Find genes that share paralogs with NGF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NGF (see all 1091)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114661121,2,,4
    C,F,HNeuropathy, hereditary sensory and autonomic, 5 (HSAN5)4 pathogenic1115897404(-) CCTGGC/TGGTTT 2 R W mis112Minor allele frequency- T:0.01NA EU NS EA 1144
    rs115844241,2
    H--113734715(+) tctttC/Tttttc 1 -- int1 trp30--------
    rs115791141,2
    H--113734716(+) ctttcC/Ttttct 1 -- int1 trp30--------
    rs1396047801,2
    C--113734717(+) TTTCT-/TTTCTTTCT
    TTCCTTCTTTC
    TTTCT
    1 -- int10--------
    rs74172541,2
    C,A--115846967(+) tttttG/Ttattt 1 -- int10--------
    rs3709967161,2
    C--115864027(+) TTGGG-/TTTTTT 1 -- int10--------
    rs670881591,2
    C--115873352(+) GACTT-/CACTC 
            
    CAAGC
    1 -- int11Minor allele frequency- CACTC:0.00CSA 2
    rs664863711,2
    C--115873354(+) CTTCA-/CTCCA 
            
    AGCAA
    1 -- int11Minor allele frequency- CTCCA:0.00NA 2
    rs802773831,2
    C--115873356(+) TCACTC/TCAAGC 1 -- int10--------
    rs725028271,2
    C--115873731(+) GGGAA-/GGGGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NGF (115828537 - 115880857 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NGF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv159371CNV Loss16902084
    esv26121CNV Loss19812545
    esv34370CNV Gain17911159
    nsv818389CNV Gain17921354
    essv21938CNV CNV17122850
    essv18166CNV CNV17122850

    Human Gene Mutation Database (HGMD): NGF
    Locus Specific Mutation Databases (LSDB): NGF

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162030   
    OMIM disorders: 608654  
    UniProtKB/Swiss-Prot: NGF_HUMAN, P01138
  • Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and
    autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration
    of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients
    manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation.
    The autonomic involvement is variable. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for NGF (see all 30):    
    About MalaCards
    ependymoblastoma    neuroschistosomiasis    autonomic neuropathy    cystitis
    corneal ulcer    diabetic autonomic neuropathy    hereditary sensory and autonomic neuropathy type v    cannabis abuse
    congenital insensitivity to pain with anhidrosis    chronic cystitis    burning mouth syndrome    anhidrosis
    diabetic polyneuropathy    cough variant asthma    askin's tumor    rhinitis
    allergic rhinitis    polyneuropathy    diabetic neuropathy    keratoconjunctivitis

    18 diseases from the University of Copenhagen DISEASES database for NGF:
    Alzheimer's disease     Neuropathy     Anhidrosis     Toxic encephalopathy
    Neuroblastoma     Phaeochromocytoma     Parkinson's disease     Cystitis
    Vascular disease     Pain disorder     Atopic dermatitis     Asthma
    Amyotrophic lateral sclerosis     Eye disease     Cholera     Diabetes mellitus
    Schizophrenia     Neuroschistosomiasis

    Find genes that share disorders with NGF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NGF gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 82.2 131 20155803 (2), 16296925 (2), 1702431 (2), 11288140 (2) (see all 99)
    hsan type v 68.9 2 15468048 (1), 19945432 (1)
    alzheimers disease 65.9 141 8282080 (5), 10198825 (4), 17404842 (4), 19680822 (4) (see all 92)
    neurodegenerative diseases 63.7 35 9829813 (3), 15175980 (2), 2130651 (1), 11263982 (1) (see all 30)
    anhidrosis 62.2 11 16138253 (1), 18955016 (1), 10567924 (1), 19201660 (1) (see all 8)
    hyperalgesia 58.1 82 7582555 (5), 12958182 (4), 10393882 (3), 18813917 (3) (see all 44)
    diabetic neuropathies 53.6 30 2375241 (3), 16528132 (2), 14699981 (2), 2142224 (2) (see all 16)
    neurodegeneration 51.9 39 20182028 (3), 16244482 (2), 16815330 (2), 19355851 (2) (see all 25)
    sensory neuropathy hereditary 45.2 2 16612677 (1), 10567924 (1)
    keratoconjunctivitis vernal 42.8 13 7657550 (6), 10224366 (1), 19844589 (1), 9331280 (1) (see all 6)

    Genetic Association Database (GAD): NGF
    Human Genome Epidemiology (HuGE) Navigator: NGF (509 documents)

    Export disorders for NGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NGF gene, integrated from 10 sources (see all 2092):
    (articles sorted by number of sources associating them with NGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation in the BDNF and NGFB genes in German atopic dermatitis patients. (PubMed id 19038326)1, 4, 9 Hoffjan S....Stemmler S. (Mol. Cell. Probes 2009)
    2. Crystal structure of nerve growth factor in complex with the ligand- binding domain of the TrkA receptor. (PubMed id 10490030)1, 2, 9 Wiesmann C.... de Vos A.M. (Nature 1999)
    3. Genomic NGFB variation and multiple sclerosis in a case control study. (PubMed id 19063739)1, 4, 9 Akkad D.A....Epplen J.T. (BMC Med. Genet. 2008)
    4. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. (PubMed id 2025430)1, 2, 9 Hallboeoek F.... Persson H. (Neuron 1991)
    5. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. (PubMed id 18780967)1, 4, 9 Cozza A....Pellegrini S. (J. Alzheimers Dis. 2008)
    6. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. (PubMed id 18179783)1, 4, 9 RibasAcs M....BayAcs M. (Biol. Psychiatry 2008)
    7. A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. (PubMed id 20978020)1, 2 Carvalho O.P.... Woods C.G. (J. Med. Genet. 2011)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    10. Genes for hereditary sensory and autonomic neuropathies: a genotype- phenotype correlation. (PubMed id 19651702)1, 4 Rotthier A.... Timmerman V. (Brain 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4803 HGNC: 7808 AceView: NGFB Ensembl:ENSG00000134259 euGenes: HUgn4803
    ECgene: NGF Kegg: 4803 H-InvDB: NGF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NGF Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Nerve_growth_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NGF gene:
    Search GeneIP for patents involving NGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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