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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NGF Gene

protein-coding GIFtS: 69
GCID: GC01M115828

nerve growth factor (beta polypeptide)

(Previous symbol: NGFB)

Explore 194 diseases affiliated with
NGF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nerve Growth Factor (Beta Polypeptide)¹ ²
NGFB¹ ² ³ ⁵
Beta-NGF² ³
HSAN5² ⁵
Beta-Nerve Growth Factor²
Nerve Growth Factor, Beta Subunit²

External Ids:	HGNC: 7808¹	Entrez Gene: 4803²	Ensembl: ENSG00000134259⁷	OMIM: 162030⁵	UniProtKB: P01138³

Export aliases for NGF gene to outside databases

Previous GC identifers: GC01M115630 GC01M113686

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NGF:

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated

into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the

regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have

been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's

expression is associated with allergic rhinitis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous

systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those

receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

summary for NGF:

Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase

activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling

pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.

p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds

different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is

involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in

neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is

involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by

neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors

with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as

an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NGF (Nerve growth factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NGF gene promoter:
AP-2alpha isoform 3 STAT5A AP-2alpha isoform 2 deltaCREB FOXO1a STAT3 AP-2alpha isoform 4 AP-2alpha AP-2alphaA FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NGF promoter sequence

Search SABiosciences Chromatin IP Primers for NGF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1

NGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGF gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M115828: view genomic region (about GC identifiers)

Start:	115,828,537 bp from pter	End:	115,880,857 bp from pter
Size:	52,321 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138 (See protein sequence)

Recommended Name: Beta-nerve growth factor precursor

Size: 241 amino acids; 26959 Da

Subunit: Homodimer

Subcellular location: Secreted

Sequence caution: Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

3 PDB 3D structures from and Proteopedia for NGF:

1SG1 (3D)

1WWW (3D)

2IFG (3D)

Secondary accessions: A1A4E5 Q6FHA0 Q96P60 Q9P2Q8 Q9UKL8

Explore the universe of human proteins at neXtProt for NGF: NX_P01138

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01138

NGF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002497.2

ENSEMBL proteins:

ENSP00000358525

Reactome Protein details: P01138
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant NGF Protein
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	Uscn Proteins for NGF

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005768	endosome	TAS	--
GO:0005788	endoplasmic reticulum lumen	--	--
GO:0005796	Golgi lumen	TAS	--

NGF for ontologies About GeneDecksing

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	ThermoFisher Antibodies for NGF

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	GenScript Custom Assay Services for NGF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NGF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NGF for domains About GeneDecksing

5 InterPro domains/families:

IPR020425 Nerve_growth_factor_bsu

IPR020437 Nerve_growth_factor_bsu_mml

IPR002072 Nerve_growth_factor-rel

IPR019846 Nerve_growth_factor_CS

IPR020408 Nerve_growth_factor-like

Graphical View of Domain Structure for InterPro Entry P01138

ProtoNet protein and cluster: P01138

1 Blocks protein family: IPB002072 Nerve growth factor

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Similarity: Belongs to the NGF-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous

systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those

receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival

Summary:

During embryonic development, NGF as signaling molecule

affects the following cells: Pre-Granulosa Cells in Primordial Follicle

NGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Motor neuron progenitors, Peripheral sensory neuron-like cells (see all 3).

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NGF
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate NGF (see all 12):
		hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGF

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005163	nerve growth factor receptor binding	IPI	14985763
GO:0008083	growth factor activity	IEA	--

NGF for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ngf^tm1Gne for NGF
     10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ngf):

behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism	integument
mortality/aging	muscle	nervous system	normal	vision/eye

NGF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development HGF signaling pathway

Development_Neurotrophin family signaling	0.45	Apoptosis and survival_Role of CDK5 in neuronal death and survival	0.24
Development Neurotrophin family signaling	0.45	Apoptosis and survival Role of CDK5 in neuronal death and survival	0.24
Apoptosis and survival_NGF signaling pathway	0.25	Neurotrophin signaling pathway	0.20
Apoptosis and survival NGF signaling pathway	0.25

p75NTR signals via NF-kB

p75NTR signals via NF-kB	1.00	TRAF6 is auto-ubiquitinated	0.56
NF-kB is activated and signals survival	0.81	NRIF signals cell death from the nucleus	0.35
p75NTR recruits signalling complexes	0.81

ARMS-mediated activation

	ARMS-mediated activation	1.00			Signalling to p38 via RIT and RIN	0.72
	Prolonged ERK activation events	0.80			Frs2-mediated activation	0.70

Cell death signalling via NRAGE, NRIF and NADE

	Cell death signalling via NRAGE, NRIF and NADE	1.00			p75 NTR receptor-mediated signalling	0.73
	NRAGE signals death through JNK	0.74

TRKA activation by NGF

	TRKA activation by NGF	1.00			Signalling to STAT3	0.67
	Activated TrkA receptor internalizes to endosomes	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for NGF (see all 6)

	Apoptosis and survival NGF signaling pathway
	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Development Neurotrophin family signaling
	Apoptosis and survival Apoptotic TNF-family pathways

1 R&D Systems Pathway for NGF

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

1 Cell Signaling Technology (CST) Pathway for NGF

Neuroscience

5/6 GeneGo (Thomson Reuters) Pathways for NGF (see all 6)

	Apoptosis and survival Apoptotic TNF-family pathways
	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Development Neurotrophin family signaling
	Apoptosis and survival NGF signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

5/6 BioSystems Pathways for NGF (see all 6)

	SIDS Susceptibility Pathways
	MAPK signaling pathway
	Id Signaling Pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
	p75(NTR)-mediated signaling

5/31 Reactome Pathways for NGF (see all 31)

	NRIF signals cell death from the nucleus
	Cell death signalling via NRAGE, NRIF and NADE
	p75NTR negatively regulates cell cycle via SC1
	p75NTR regulates axonogenesis
	Retrograde neurotrophin signalling

3 Kegg Pathways (Kegg details for NGF):

	MAPK signaling pathway
	Apoptosis
	Neurotrophin signaling pathway

NGF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/90 Interacting proteins for NGF (P01138^{2, 3} ENSP00000358525⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 90)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SORCS3	Q9UPU3²^,³, ENSP00000358715⁴	MINT-56552 MINT-56551 MINT-56550 I2D: score=2 STRING: ENSP00000358715
NGFR	P08138³, ENSP00000172229⁴	I2D: score=4 STRING: ENSP00000172229
MMP7	P09237³, ENSP00000260227⁴	I2D: score=1 STRING: ENSP00000260227
NTRK1	P04629³, ENSP00000351486⁴	I2D: score=5 STRING: ENSP00000351486
SORT1	Q99523³, ENSP00000256637⁴	I2D: score=2 STRING: ENSP00000256637

About this table

Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	TAS	--
GO:0006915	apoptotic process	TAS	--
GO:0006954	inflammatory response	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	--
GO:0007202	activation of phospholipase C activity	TAS	--

NGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NGF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for NGF available from Tocris Bioscience About this table

Compound	Action	CAS #
BDNF (human)	Activates TrkB and p75 receptors	[218441-99-7]
Ro 08-2750	Inhibits NGF binding to p75NTR and TrkA	[37854-59-4]
NTR 368	p75NTR fragment; induces apoptosis	[197230-90-3]

1 DrugBank Compound for NGF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Clenbuterol	--	37148-27-9	target	stimulator	10637819 10525174 11146120 11221812 10403429

10/134 Novoseek chemical compound relationships for NGF gene (see all 134) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
k252a	87	67	11997324 (3), 1314657 (2), 14532844 (2), 10595705 (2) (see all 44)
tyrosine	78.8	463	1712104 (5), 1706478 (4), 7815475 (4), 1647176 (3) (see all 99)
cipa	69.8	15	15114061 (3), 18955016 (2), 16138253 (1), 10567924 (1) (see all 9)
dbc-amp	57.7	69	2164566 (4), 19176979 (4), 11572090 (4), 2166778 (4) (see all 27)
propentofylline	57.2	18	8951894 (4), 9621361 (2), 15617731 (1), 9062669 (1) (see all 7)
choline	54.2	36	8294910 (3), 11738495 (2), 2044677 (1), 9168835 (1) (see all 26)
pd 98,059	54	25	11731549 (2), 9012803 (2), 9518660 (2), 10617652 (1) (see all 17)
ly294002	53.1	20	9786998 (2), 11223915 (2), 14614965 (2), 9348296 (1) (see all 15)
phosphatidylinositol	50.5	41	9348296 (3), 10050043 (3), 1382475 (2), 9681989 (2) (see all 25)
cyclic amp	46.9	86	7798916 (5), 15546918 (4), 19176979 (4), 2156018 (4) (see all 26)

Search CenterWatch for drugs/clinical trials and news about NGF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NGF gene:

NM_002506.2

Unigene Cluster for NGF:

Nerve growth factor (beta polypeptide)

Hs.2561 [show with all ESTs]

Unigene Representative Sequence: BC032517

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369512(uc001efu.1)

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		hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g

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Additional cDNA sequence:

AF411526.1 BC032517.2 BC126148.1 BC126150.1 BT019733.1 CR541855.1 X52599.1

1 DOTS entry:

DT.310657

22 AceView cDNA sequences:

NM_002506 BC032517 X52599 CR541855 CD614999 BM449450 AI700604 BE045524

CD614997 BF223074 AF411526 CD614993 BE467625 CD614995 AW770784 AA610120

AA928118 T52484 T56316 AI341450 AW086159 CD614991

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NGF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAATTTATA

About this image

NGF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Anterior neural specified EBs (Differentiation of h...)

Photoreceptor-like cells (Differentiation of h...)

See NGF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NGF

SOURCE GeneReport for Unigene cluster: Hs.2561

SABiosciences Expression via Pathway-Focused PCR Arrays including NGF:

Growth Factors in human mouse rat

Neurotrophins & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

Necrosis in human mouse rat

Synaptic Plasticity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NGF gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NGF¹	nerve growth factor (beta polypeptide)	71.16(n) 69.13(a)		396466 XM_418016.3 XP_418016.3
lizard (Anolis carolinensis)	Reptilia	B8QCF9_ANOCA⁶	Nerve growth factor beta polypeptide Fragment	54(a)	1 ↔ 1	4(130884200-130884781)
zebrafish (Danio rerio)	Actinopterygii	ntf7²	neurotrophin 7	78.28(n)		30270 AY162427.1

ENSEMBL Gene Tree for NGF (if available)
TreeFam Gene Tree for NGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NGF gene

NTF3² NTF4² BDNF²

3 SIMAP similar genes for NGF using alignment to 1 protein entry: NGF_HUMAN:

NTF3 NTF4 BDNF

NGF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11466112^1,2	C,F,H	pathogenic	113687134(-)	`CCTGGC/TGGTTT`	2	R W	mis¹		12		NA EU NS EA	1144
rs11466113^1,2	C,F,H,	--	113686649(-)	`GATTAC/TCTGCC`	1	--	ds500¹		16		NA EU NS EA CSA WA	1505
rs80277627^1,2	C,	--	113687128(+)	`CCGGAA/TAAACC`	2	I F	mis¹		0	--	--	--	--
rs202138909^1,2	C	--	113687353(-)	`AGACCA/CCNNNN`	2	T P	mis¹		0	--	--	--	--
rs3730194^1,2	C,F,H,	--	113687924(-)	`GCCCCG/CGTTTG`	1	--	int¹		7		NS EA NA EU	512
rs78220001^1,2		--	113688180(+)	`AGGCCA/GGTGGG`	1	--	int¹		0	--	--	--	--
rs6331^1,2	C,	--	113688272(-)	`TTCCCC/TGTGCC`	1	--	int¹		3		MN NA WA	194
rs11466109^1,2	C,F,H,	--	113688828(-)	`GCAGTG/ACAGTA`	1	--	int¹		8		NA EU NS EA WA	510
rs6326^1,2	C,F,O,H,	--	113688839(-)	`GTGGGG/CTAACT`	1	--	int¹		16		MN NA EU NS EA WA CSA	852
rs3730184^1,2	H	--	113688840(-)	`TGTGGG/CCTAAC`	1	--	int¹		4		NS EA	414

HapMap Linkage Disequilibrium report for NGF (115828537 - 115880857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for NGF
6 CNVs: 9369 5512 64659 2322 8325 3306
Human Gene Mutation Database (HGMD): NGF

Locus Specific Mutation Databases (LSDB): NGF

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NGF

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NGF for disorders           About GeneDecksing

OMIM gene information: 162030
OMIM disorders: 608654
UniProtKB/Swiss-Prot: NGF_HUMAN, P01138

Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The

hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders

characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic

abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in

some cases self-mutilation. The autonomic involvement is variable

20/194 diseases for NGF (see all 194): About MalaCards

autonomic neuropathy allergic rhinitis neuropathy anxiety-related personality traits

rhinitis hereditary sensory and autonomic neuropathy type v thyroid carcinoma lesch-nyhan syndrome

relapsing-remitting multiple sclerosis cannabis abuse attention deficit hyperactivity disorder diabetic autonomic neuropathy

primitive neuroectodermal tumor chronic inflammatory demyelinating polyneuropathy carcinoma neuroaxonal dystrophy

ependymoblastoma demyelinating polyneuropathy supranuclear palsy burning mouth syndrome

17 diseases from the University of Copenhagen DISEASES database for NGF:

Alzheimer's disease Neuropathy Toxic encephalopathy Anhidrosis

Neuroblastoma Phaeochromocytoma Parkinson's disease Cystitis

Vascular disease Pain disorder Amyotrophic lateral sclerosis Atopic dermatitis

Asthma Cholera Eye disease Diabetes mellitus

Schizophrenia

10/94 Novoseek disease relationships for NGF gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	82.2	131	20155803 (2), 16296925 (2), 1702431 (2), 11288140 (2) (see all 99)
hsan type v	68.9	2	15468048 (1), 19945432 (1)
alzheimers disease	65.9	141	8282080 (5), 10198825 (4), 17404842 (4), 19680822 (4) (see all 92)
neurodegenerative diseases	63.7	35	9829813 (3), 15175980 (2), 2130651 (1), 11263982 (1) (see all 30)
anhidrosis	62.2	11	16138253 (1), 18955016 (1), 10567924 (1), 19201660 (1) (see all 8)
hyperalgesia	58.1	82	7582555 (5), 12958182 (4), 10393882 (3), 18813917 (3) (see all 44)
diabetic neuropathies	53.6	30	2375241 (3), 16528132 (2), 14699981 (2), 2142224 (2) (see all 16)
neurodegeneration	51.9	39	20182028 (3), 16244482 (2), 16815330 (2), 19355851 (2) (see all 25)
sensory neuropathy hereditary	45.2	2	16612677 (1), 10567924 (1)
keratoconjunctivitis vernal	42.8	13	7657550 (6), 10224366 (1), 19844589 (1), 9331280 (1) (see all 6)

Human Genome Epidemiology (HuGE) Navigator: NGF (509 documents)

Export disorders for NGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NGF gene, integrated from 9 sources (see all 2070):
(articles sorted by number of sources associating them with NGF)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structure of nerve growth factor in complex with the ligand- binding domain of the TrkA receptor. (PubMed id 10490030)^{1, 2, 9} Wiesmann C.... de Vos A.M. (1999)
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. (PubMed id 2025430)^{1, 2, 9} Hallboeoek F.... Persson H. (1991)
A novel NGF mutation clarifies the molecular mechanis m and extends the phenotypic spectrum of the HSAN5 neuropathy. (PubMed id 20978020)^{1, 2} Carvalho O.P....Woods C.G. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. (PubMed id 14976160)^{1, 2} Einarsdottir E.... Holmberg M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{1, 2} Cargill M....Lander E.S. (1999)
Cloning and sequencing of the gene for premature beta nerve growth factor. (PubMed id 10322959)^{1, 2} Tong Y.... Chen W. (1997)
cDNA sequence of human beta-NGF. (PubMed id 2374737)^{1, 2} Borsani G.... Barelle F.E. (1990)
Human beta-nerve growth factor gene sequence highly homologous to that of mouse. (PubMed id 6688123)^{1, 2} Ullrich A.... Dull T.J. (1983)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4803	HGNC: 7808	AceView: NGFB	Ensembl:ENSG00000134259	euGenes: HUgn4803
ECgene: NGF	Kegg: 4803	H-InvDB: NGF

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NGF	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Nerve_growth_factor

Intellectual Property for NGF gene
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Patent Information for NGF gene:
Search GeneIP for patents involving NGF

GeneCards and IP:
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NGF Gene

nerve growth factor (beta polypeptide)

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