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Aliases for NGF Gene

Aliases for NGF Gene

  • Nerve Growth Factor 2 3 5
  • Nerve Growth Factor (Beta Polypeptide) 2 3
  • Beta-NGF 3 4
  • NGFB 3 4
  • Nerve Growth Factor, Beta Subunit 3
  • Beta-Nerve Growth Factor 3
  • HSAN5 3

External Ids for NGF Gene

Previous HGNC Symbols for NGF Gene

  • NGFB

Previous GeneCards Identifiers for NGF Gene

  • GC01M115630
  • GC01M115828
  • GC01M113686

Summaries for NGF Gene

Entrez Gene Summary for NGF Gene

  • This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGF Gene

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are p70S6K Signaling and CREB Pathway. GO annotations related to this gene include receptor binding and receptor signaling protein activity. An important paralog of this gene is NTF3.

UniProtKB/Swiss-Prot for NGF Gene

  • Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

Tocris Summary for NGF Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.

Gene Wiki entry for NGF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGF Gene

Genomics for NGF Gene

Regulatory Elements for NGF Gene

Enhancers for NGF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NGF on UCSC Golden Path with GeneCards custom track

Promoters for NGF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NGF on UCSC Golden Path with GeneCards custom track

Genomic Location for NGF Gene

Chromosome:
1
Start:
115,285,916 bp from pter
End:
115,338,384 bp from pter
Size:
52,469 bases
Orientation:
Minus strand

Genomic View for NGF Gene

Genes around NGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGF Gene

Proteins for NGF Gene

  • Protein details for NGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01138-NGF_HUMAN
    Recommended name:
    Beta-nerve growth factor
    Protein Accession:
    P01138
    Secondary Accessions:
    • A1A4E5
    • Q6FHA0
    • Q96P60
    • Q9P2Q8
    • Q9UKL8

    Protein attributes for NGF Gene

    Size:
    241 amino acids
    Molecular mass:
    26959 Da
    Quaternary structure:
    • Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.
    SequenceCaution:
    • Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NGF Gene

neXtProt entry for NGF Gene

Post-translational modifications for NGF Gene

  • Glycosylation at Thr 46, Asn 69, and Asn 114
  • Modification sites at PhosphoSitePlus

Other Protein References for NGF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NGF Gene

Domains & Families for NGF Gene

Gene Families for NGF Gene

Suggested Antigen Peptide Sequences for NGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01138

UniProtKB/Swiss-Prot:

NGF_HUMAN :
  • Belongs to the NGF-beta family.
Family:
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NGF: view

Function for NGF Gene

Molecular function for NGF Gene

UniProtKB/Swiss-Prot Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

Gene Ontology (GO) - Molecular Function for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005163 nerve growth factor receptor binding IPI 14985763
GO:0005515 protein binding IPI 10490030
GO:0008083 growth factor activity IBA --
GO:0008191 metalloendopeptidase inhibitor activity IDA 20164177
genes like me logo Genes that share ontologies with NGF: view
genes like me logo Genes that share phenotypes with NGF: view

Human Phenotype Ontology for NGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NGF Gene

MGI Knock Outs for NGF:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NGF Gene

Localization for NGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGF Gene COMPARTMENTS Subcellular localization image for NGF gene
Compartment Confidence
endosome 5
extracellular 5
golgi apparatus 5
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005768 endosome TAS --
GO:0005796 Golgi lumen TAS --
GO:0016023 cytoplasmic, membrane-bounded vesicle IBA --
genes like me logo Genes that share ontologies with NGF: view

Pathways & Interactions for NGF Gene

SuperPathways for NGF Gene

Superpath Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
2 p75 NTR receptor-mediated signalling
3 Interleukin-3, 5 and GM-CSF signaling
4 GPCR Pathway
5 ERK Signaling
genes like me logo Genes that share pathways with NGF: view

SIGNOR curated interactions for NGF Gene

Activates:

Gene Ontology (GO) - Biological Process for NGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
genes like me logo Genes that share ontologies with NGF: view

Drugs & Compounds for NGF Gene

(90) Drugs for NGF Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clenbuterol Approved, Vet_approved Pharma Target, stimulator 3
Methadone Approved Pharma 310
RI 624 Investigational Pharma Target 0
CERE-110 Investigational Pharma 0
Cyclotraxin B Pharma TrkB receptor antagonist 0

(57) Additional Compounds for NGF Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
HIOC
314054-36-9

(5) Tocris Compounds for NGF Gene

Compound Action Cas Number
ANA 12 TrkB receptor antagonist 219766-25-3
BDNF (human) Activates TrkB and p75 receptors 218441-99-7
Cyclotraxin B TrkB receptor antagonist 1203586-72-4
HIOC Selective TrkB receptor agonist; neuroprotectant 314054-36-9
LM 22A4 Potent TrkB agonist 37988-18-4

(2) ApexBio Compounds for NGF Gene

Compound Action Cas Number
Cyclotraxin B 1203586-72-4
Ro 08-2750 antagonist of nerve growth factor (NGF) 37854-59-4
genes like me logo Genes that share compounds with NGF: view

Transcripts for NGF Gene

mRNA/cDNA for NGF Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NGF Gene

Nerve growth factor (beta polypeptide):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGF Gene

No ASD Table

Relevant External Links for NGF Gene

GeneLoc Exon Structure for
NGF
ECgene alternative splicing isoforms for
NGF

Expression for NGF Gene

mRNA expression in normal human tissues for NGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NGF Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.7), Ovary (x4.6), and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for NGF Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NGF Gene



Protein tissue co-expression partners for NGF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NGF Gene:

NGF

SOURCE GeneReport for Unigene cluster for NGF Gene:

Hs.2561
genes like me logo Genes that share expression patterns with NGF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NGF Gene

Orthologs for NGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for NGF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NGF 34
  • 87.97 (n)
  • 90.87 (a)
NGF 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGF 34
  • 87.41 (n)
  • 90.87 (a)
NGFB 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngf 34
  • 85.48 (n)
  • 85.06 (a)
Ngf 16
Ngf 35
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NGF 34
  • 99.03 (n)
  • 99.17 (a)
NGF 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngf 34
  • 85.62 (n)
  • 85.89 (a)
oppossum
(Monodelphis domestica)
Mammalia NGF 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NGF 34
  • 70.23 (n)
  • 67.09 (a)
NGF 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGFB 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngf 34
  • 69.05 (n)
  • 68.3 (a)
zebrafish
(Danio rerio)
Actinopterygii ngf 35
  • 51 (a)
OneToMany
ntf7 35
  • 44 (a)
OneToMany
ntf7 34
Species where no ortholog for NGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGF Gene

ENSEMBL:
Gene Tree for NGF (if available)
TreeFam:
Gene Tree for NGF (if available)

Paralogs for NGF Gene

Paralogs for NGF Gene

(3) SIMAP similar genes for NGF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NGF: view

Variants for NGF Gene

Sequence variations from dbSNP and Humsavar for NGF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6330 - 115,286,692(-) CCAAG(C/T)CCACT reference, missense
rs11466110 - 115,286,582(-) TTACT(A/G)TGGAC reference, missense
rs11466111 - 115,286,557(-) AAAGC(A/G)GCGAC reference, missense
rs11466112 Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) 115,286,135(-) CCTGG(C/T)GGTTT reference, missense
VAR_068479 -

Structural Variations from Database of Genomic Variants (DGV) for NGF Gene

Variant ID Type Subtype PubMed ID
esv26121 CNV loss 19812545
esv34370 CNV gain 17911159
nsv159371 CNV deletion 16902084
nsv818389 CNV gain 17921354

Variation tolerance for NGF Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NGF Gene

Human Gene Mutation Database (HGMD)
NGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGF Gene

Disorders for NGF Gene

MalaCards: The human disease database

(31) MalaCards diseases for NGF Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuropathy, hereditary sensory and autonomic, type v
  • insensitivity to pain, congenital
autonomic neuropathy
neuropathy
  • peripheral neuropathy
ischemic neuropathy
  • ischemic peripheral neuropathy
anhidrosis
  • absence of sweating
- elite association - COSMIC cancer census association via MalaCards
Search NGF in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NGF_HUMAN
  • Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. {ECO:0000269 PubMed:14976160, ECO:0000269 PubMed:22302274}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NGF

Genetic Association Database (GAD)
NGF
Human Genome Epidemiology (HuGE) Navigator
NGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NGF
genes like me logo Genes that share disorders with NGF: view

No data available for Genatlas for NGF Gene

Publications for NGF Gene

  1. A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. (PMID: 20978020) Carvalho O.P. … Woods C.G. (J. Med. Genet. 2011) 3 4 65
  2. Nerve growth factor promotes cardiac repair following myocardial infarction. (PMID: 20360245) Meloni M. … Emanueli C. (Circ. Res. 2010) 3 22 65
  3. Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI. (PMID: 20164177) Wijeyewickrema L.C. … Andrews R.K. (J. Biol. Chem. 2010) 3 4 65
  4. Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis. (PMID: 18922683) Yamaguchi J. … Ikezawa Z. (J. Dermatol. Sci. 2009) 3 22 65
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 65

Products for NGF Gene

Sources for NGF Gene

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