Aliases for NGEF Gene
External Ids for NGEF Gene
Previous GeneCards Identifiers for NGEF Gene
GeneCards Summary for NGEF Gene
NGEF (Neuronal Guanine Nucleotide Exchange Factor) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF5.
UniProtKB/Swiss-Prot for NGEF Gene
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).