Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NGDN Gene

Aliases for NGDN Gene

  • Neuroguidin, EIF4E Binding Protein 2 3
  • Centromere Accumulated Nuclear Protein 1 3 4
  • EIF4E-Binding Protein 3 4
  • C14orf120 3 4
  • CANu1 3 4
  • Eukaryotic Initiation Factor 4E And CPEB Binding Protein 3
  • Chromosome 14 Open Reading Frame 120 2
  • Lpd-2 3
  • LCP5 3
  • NGD 3

External Ids for NGDN Gene

Previous HGNC Symbols for NGDN Gene

  • C14orf120

Previous GeneCards Identifiers for NGDN Gene

  • GC14P023009
  • GC14P023924
  • GC14P004055

Summaries for NGDN Gene

Entrez Gene Summary for NGDN Gene

  • Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NGDN Gene

NGDN (Neuroguidin, EIF4E Binding Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for NGDN Gene

  • Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGDN Gene

Genomics for NGDN Gene

Regulatory Elements for NGDN Gene

Genomic Location for NGDN Gene

Chromosome:
14
Start:
23,469,628 bp from pter
End:
23,509,862 bp from pter
Size:
40,235 bases
Orientation:
Plus strand

Genomic View for NGDN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NGDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGDN Gene

Proteins for NGDN Gene

  • Protein details for NGDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEJ9-NGDN_HUMAN
    Recommended name:
    Neuroguidin
    Protein Accession:
    Q8NEJ9
    Secondary Accessions:
    • A8K760
    • Q9Y400

    Protein attributes for NGDN Gene

    Size:
    315 amino acids
    Molecular mass:
    35894 Da
    Quaternary structure:
    • Interacts with CPEB1 and EIF4E.

    Alternative splice isoforms for NGDN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGDN Gene

Proteomics data for NGDN Gene at MOPED

Post-translational modifications for NGDN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NGDN Gene

No data available for DME Specific Peptides for NGDN Gene

Domains & Families for NGDN Gene

Protein Domains for NGDN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEJ9

UniProtKB/Swiss-Prot:

NGDN_HUMAN :
  • Belongs to the SAS10 family.
Family:
  • Belongs to the SAS10 family.
genes like me logo Genes that share domains with NGDN: view

No data available for Gene Families for NGDN Gene

Function for NGDN Gene

Molecular function for NGDN Gene

UniProtKB/Swiss-Prot Function:
Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

Gene Ontology (GO) - Molecular Function for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NGDN: view

Phenotypes for NGDN Gene

genes like me logo Genes that share phenotypes with NGDN: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NGDN Gene

Localization for NGDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGDN Gene

Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium. Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGDN Gene COMPARTMENTS Subcellular localization image for NGDN gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IEA --
GO:0030175 filopodium IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with NGDN: view

Pathways & Interactions for NGDN Gene

SuperPathways for NGDN Gene

No Data Available

Interacting Proteins for NGDN Gene

Gene Ontology (GO) - Biological Process for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with NGDN: view

No data available for Pathways by source and SIGNOR curated interactions for NGDN Gene

Drugs & Compounds for NGDN Gene

No Compound Related Data Available

Transcripts for NGDN Gene

Unigene Clusters for NGDN Gene

Neuroguidin, EIF4E binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NGDN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8:
SP9:

Relevant External Links for NGDN Gene

GeneLoc Exon Structure for
NGDN
ECgene alternative splicing isoforms for
NGDN

Expression for NGDN Gene

mRNA expression in normal human tissues for NGDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NGDN Gene

This gene is overexpressed in Lung (36.4) and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NGDN Gene



SOURCE GeneReport for Unigene cluster for NGDN Gene Hs.9043

genes like me logo Genes that share expression patterns with NGDN: view

Protein tissue co-expression partners for NGDN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NGDN Gene

Orthologs for NGDN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NGDN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NGDN 35
  • 90.36 (n)
  • 93.54 (a)
NGDN 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGDN 35
  • 91.7 (n)
  • 93.43 (a)
NGDN 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngdn 35
  • 86.02 (n)
  • 88.71 (a)
Ngdn 16
Ngdn 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NGDN 35
  • 99.46 (n)
  • 99.03 (a)
NGDN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngdn 35
  • 86.67 (n)
  • 90 (a)
oppossum
(Monodelphis domestica)
Mammalia NGDN 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGDN 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGDN 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC395016 35
ngdn 35
  • 60.75 (n)
  • 61.61 (a)
zebrafish
(Danio rerio)
Actinopterygii ngdn 35
  • 58.5 (n)
  • 56.29 (a)
zgc66416 35
ngdn 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008697 35
  • 52.59 (n)
  • 47.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11030 35
  • 52.78 (n)
  • 46.18 (a)
CG11030 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lpd-2 35
  • 48.47 (n)
  • 38.53 (a)
lpd-2 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07840 35
  • 44.12 (n)
  • 34.93 (a)
rice
(Oryza sativa)
Liliopsida Os01g0911000 35
  • 45.3 (n)
  • 36.29 (a)
Species with no ortholog for NGDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NGDN Gene

ENSEMBL:
Gene Tree for NGDN (if available)
TreeFam:
Gene Tree for NGDN (if available)

Paralogs for NGDN Gene

No data available for Paralogs for NGDN Gene

Variants for NGDN Gene

Sequence variations from dbSNP and Humsavar for NGDN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1028586 -- 23,470,676(+) CTCCC(C/T)GTGGT intron-variant
rs1028587 -- 23,470,872(+) ATATA(A/G)TCTAA intron-variant
rs1028588 -- 23,470,877(+) ATCTA(A/G)TCACT intron-variant
rs1028589 -- 23,471,150(+) TAAGT(A/G)TTAAT intron-variant
rs1956950 -- 23,478,165(+) ATTTT(A/G)CTTAT utr-variant-3-prime

Variation tolerance for NGDN Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NGDN Gene

HapMap Linkage Disequilibrium report
NGDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NGDN Gene

Disorders for NGDN Gene

Relevant External Links for NGDN

Genetic Association Database (GAD)
NGDN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NGDN
genes like me logo Genes that share disorders with NGDN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NGDN Gene

Publications for NGDN Gene

  1. Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. (PMID: 16705177) Jung M.Y. … Richter J.D. (Mol. Cell. Biol. 2006) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for NGDN Gene

Sources for NGDN Gene

Back to Top

Content