Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NGDN Gene

Aliases for NGDN Gene

  • Neuroguidin 2 3 3 5
  • Centromere Accumulated Nuclear Protein 1 3 4
  • Neuroguidin, EIF4E Binding Protein 2 3
  • EIF4E-Binding Protein 3 4
  • C14orf120 3 4
  • CANu1 3 4
  • Eukaryotic Initiation Factor 4E And CPEB Binding Protein 3
  • Chromosome 14 Open Reading Frame 120 2
  • Lpd-2 3
  • LCP5 3
  • NGD 3

External Ids for NGDN Gene

Previous HGNC Symbols for NGDN Gene

  • C14orf120

Previous GeneCards Identifiers for NGDN Gene

  • GC14P023009
  • GC14P023924
  • GC14P004055

Summaries for NGDN Gene

Entrez Gene Summary for NGDN Gene

  • Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NGDN Gene

NGDN (Neuroguidin) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for NGDN Gene

  • Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGDN Gene

Genomics for NGDN Gene

Regulatory Elements for NGDN Gene

Enhancers for NGDN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F023468 1.1 ENCODE 7.9 0.0 -30 2.0 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NOP9 OXA1L KHNYN PABPN1 PPP1R3E BCL2L2 THTPA HOMEZ NFATC4 LRP10
GH14F023484 1.1 ENCODE 6.2 +16.1 16067 1.4 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000157306 ZFHX2 THTPA NGDN
GH14F023482 1 ENCODE 6.2 +13.5 13508 2.4 ZFP64 ARID4B ZNF2 ZNF48 YY1 ZNF202 SP3 SP5 NFYC REST NYNRIN NFATC4 PABPN1 ENSG00000259321 HOMEZ MDP1 PRMT5-AS1 RNA5SP383 LOC102724814 NOP9
GH14F023453 0.9 ENCODE 6.8 -15.2 -15242 1.8 ELF3 ARNT MLX ARID4B ZSCAN9 SLC30A9 MIXL1 HMG20B NCOA1 ZEB2 MYH6 MIR208B SLC22A17 MIR208A ENSG00000157306 ZFHX2 BCL2L2 CMTM5 IL25 HOMEZ
GH14F023478 0.8 ENCODE 7.6 +9.0 9009 0.9 ELF3 CTCF ATF1 SAP130 ARID4B ZNF384 ZSCAN9 RAD21 GATA3 POLR2A ENSG00000157306 ZFHX2 THTPA AP1G2 MYH7 MIR208B NGDN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NGDN on UCSC Golden Path with GeneCards custom track

Promoters for NGDN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096918 -27 2000 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for NGDN Gene

Chromosome:
14
Start:
23,469,628 bp from pter
End:
23,509,862 bp from pter
Size:
40,235 bases
Orientation:
Plus strand

Genomic View for NGDN Gene

Genes around NGDN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGDN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGDN Gene

Proteins for NGDN Gene

  • Protein details for NGDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEJ9-NGDN_HUMAN
    Recommended name:
    Neuroguidin
    Protein Accession:
    Q8NEJ9
    Secondary Accessions:
    • A8K760
    • Q9Y400

    Protein attributes for NGDN Gene

    Size:
    315 amino acids
    Molecular mass:
    35894 Da
    Quaternary structure:
    • Interacts with CPEB1 and EIF4E.

    Alternative splice isoforms for NGDN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NGDN Gene

Post-translational modifications for NGDN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NGDN Gene

No data available for DME Specific Peptides for NGDN Gene

Domains & Families for NGDN Gene

Protein Domains for NGDN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NGDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEJ9

UniProtKB/Swiss-Prot:

NGDN_HUMAN :
  • Belongs to the SAS10 family.
Family:
  • Belongs to the SAS10 family.
genes like me logo Genes that share domains with NGDN: view

No data available for Gene Families for NGDN Gene

Function for NGDN Gene

Molecular function for NGDN Gene

UniProtKB/Swiss-Prot Function:
Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.

Gene Ontology (GO) - Molecular Function for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NGDN: view
genes like me logo Genes that share phenotypes with NGDN: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NGDN Gene

Localization for NGDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGDN Gene

Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium. Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NGDN gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA,IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NGDN: view

Pathways & Interactions for NGDN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NGDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with NGDN: view

No data available for Pathways by source and SIGNOR curated interactions for NGDN Gene

Transcripts for NGDN Gene

Unigene Clusters for NGDN Gene

Neuroguidin, EIF4E binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NGDN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8:
SP9:

Relevant External Links for NGDN Gene

GeneLoc Exon Structure for
NGDN
ECgene alternative splicing isoforms for
NGDN

Expression for NGDN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NGDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NGDN Gene

This gene is overexpressed in Lung (36.4) and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NGDN Gene



Protein tissue co-expression partners for NGDN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NGDN Gene:

NGDN

SOURCE GeneReport for Unigene cluster for NGDN Gene:

Hs.9043
genes like me logo Genes that share expression patterns with NGDN: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NGDN Gene

Orthologs for NGDN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NGDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGDN 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia NGDN 34 35
  • 91.7 (n)
cow
(Bos Taurus)
Mammalia NGDN 34 35
  • 90.36 (n)
rat
(Rattus norvegicus)
Mammalia Ngdn 34
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Ngdn 34 16 35
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia NGDN 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGDN 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGDN 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngdn 34
  • 60.75 (n)
LOC395016 34
zebrafish
(Danio rerio)
Actinopterygii ngdn 34 35
  • 58.5 (n)
zgc66416 34
fruit fly
(Drosophila melanogaster)
Insecta CG11030 34 35
  • 52.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008697 34
  • 52.59 (n)
worm
(Caenorhabditis elegans)
Secernentea lpd-2 34 35
  • 48.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07840 34
  • 44.12 (n)
rice
(Oryza sativa)
Liliopsida Os01g0911000 34
  • 45.3 (n)
Species where no ortholog for NGDN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NGDN Gene

ENSEMBL:
Gene Tree for NGDN (if available)
TreeFam:
Gene Tree for NGDN (if available)

Paralogs for NGDN Gene

No data available for Paralogs for NGDN Gene

Variants for NGDN Gene

Sequence variations from dbSNP and Humsavar for NGDN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10131725 -- 23,473,179(+) TTTTT(A/G)GTAAA intron-variant
rs10142383 -- 23,473,326(+) TTTCA(C/G)TGCCT intron-variant
rs10149626 -- 23,470,072(+) GTGCC(C/G/T)TGACA reference, missense
rs1028586 -- 23,470,676(+) CTCCC(C/T)GTGGT intron-variant
rs1028587 -- 23,470,872(+) ATATA(A/G)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NGDN Gene

Variant ID Type Subtype PubMed ID
nsv1040319 CNV gain 25217958

Variation tolerance for NGDN Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NGDN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NGDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGDN Gene

Disorders for NGDN Gene

Relevant External Links for NGDN

Genetic Association Database (GAD)
NGDN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NGDN

No disorders were found for NGDN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NGDN Gene

Publications for NGDN Gene

  1. CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage. (PMID: 18547334) Sihn C.R. … Kim S.H. (Genes Cells 2008) 3 4 64
  2. Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. (PMID: 16705177) Jung M.Y. … Richter J.D. (Mol. Cell. Biol. 2006) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64

Products for NGDN Gene

Sources for NGDN Gene

Content
Loading form....