NGDN Gene
protein-coding GIFtS: 41
GCID: GC14P023924
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neuroguidin, EIF4E binding protein(Previous name: chromosome 14 open reading frame 120 )
(Previous symbol: C14orf120)
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Aliases
for NGDN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuroguidin, EIF4E Binding Protein1 2 | | EIF4E-Binding Protein2 3 | | C14orf1201 2 3 | | DKFZP564O0921 | | NGD1 2 5 | | Chromosome 14 Open Reading Frame 1201 | | LCP51 2 | | Eukaryotic Initiation Factor 4E And CPEB Binding Protein2 | | Lpd-21 | | Neuroguidin1 |
Export aliases for NGDN gene to outside databasesPrevious GC identifers: GC14P023009 GC14P004055 |
Summaries
for NGDN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NGDN:
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as atranslational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 (PubMed16705177)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: NGDN_HUMAN, Q8NEJ9Function: Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (Bysimilarity)
|
Genomic Views
for NGDN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NGDN gene promoter:
Max1 Tal-1 GATA-1 E47 COMP1 HOXA5 c-Myc RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for NGDN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NGDN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2NGDN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P023924: view genomic region
(about GC identifiers)
Start:
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23,938,897 bp from pter |
End:
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23,979,071 bp from pter |
Size:
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40,175 bases |
Orientation:
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plus strand |
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Proteins
for NGDN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NGDN_HUMAN, Q8NEJ9 (See
protein sequence)Recommended Name: Neuroguidin Size: 315 amino acids; 35894 Da
Subunit: Interacts with CPEB1 and EIF4E (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, axon (By similarity). Cellprojection, dendrite (By similarity). Cell projection, filopodium (By similarity). Note=Detected in axons, dendritesand filopodia. Colocalized with EIF4E in neurites (By similarity)
Secondary accessions: A8K760 Q9Y400Alternative splicing: 2 isoforms: Q8NEJ9-1 Q8NEJ9-2 (May be due to a competing donor splice site)Explore the universe of human proteins at neXtProt for NGDN: NX_Q8NEJ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NEJ9
NGDN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001036100.1 NP_056329.1
ENSEMBL proteins: ENSP00000386134 ENSP00000380340 ENSP00000451779 ENSP00000450659 ENSP00000452608 ENSP00000451942
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NGDN for ontologies About GeneDecksing
NGDN Antibody Products:
Assay Products for NGDN: |
Protein
Domains /
Families
for NGDN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NGDN for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NEJ9ProtoNet protein and cluster: Q8NEJ9 UniProtKB/Swiss-Prot: NGDN_HUMAN, Q8NEJ9Similarity: Belongs to the SAS10 family |
Function
for NGDN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NGDN_HUMAN, Q8NEJ9Function: Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NGDN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NGDN (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NGDN (NM_015514) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NGDN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGDN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGDN |
2 GenomeRNAi human phenotypes for NGDN:
|
Pathways & Interactions
for NGDN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NGDN
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for NGDN (ENSP000003861344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006417 | regulation of translation |
IEA | -- |
NGDN for ontologies About GeneDecksing
|
Drugs & Compounds
for NGDN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NGDN
Search CenterWatch for drugs/clinical trials and news about NGDN
|
Transcripts
for NGDN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NGDN gene (2 alternative transcripts): NM_001042635.1 NM_015514.1 Unigene Cluster for NGDN: Neuroguidin, EIF4E binding protein Hs.9043 [show with all ESTs]Unigene Representative Sequence: AK12431813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000408901(uc001wjy.3) ENST00000556378 ENST00000557097 ENST00000553336
ENST00000397154(uc001wjz.3) ENST00000553439 ENST00000555128 ENST00000556953
ENST00000556483 ENST00000556022 ENST00000556580 ENST00000556103 ENST00000556699
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NGDN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NGDN (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NGDN (NM_015514) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NGDN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGDN |
Additional cDNA sequence: AK124318.1 AK291875.1 AL050003.1 BC030817.1 10 DOTS entries: DT.214709 DT.100807929 DT.95336546 DT.92429731 DT.101983718 DT.95336534 DT.95336542 DT.95336510 DT.97847007 DT.95132778 24/184 AceView cDNA sequences (see all 184): BM680339 BG105307 BM766471 BM756669 BU071871 CR598616 BG031301 BQ945149 BM757636 BX379895 BM046313 BM758176 BU664841 AW965137 AK124318 CR599950 CR610556 BM724177 CD683696 CR598946 BM770764 BM746843 C14579 BQ267704
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NGDN (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NGDN
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Expression
for NGDN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NGDN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAAGAGC
About this image
See NGDN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NGDN
SOURCE GeneReport for Unigene cluster: Hs.9043
SABiosciences Custom PCR Arrays for NGDN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NGDN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NGDN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NGDN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NGDN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGDN |
Orthologs
for NGDN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NGDN gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for NGDN (if available)
TreeFam Gene Tree for NGDN (if available) |
Paralogs
for NGDN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NGDN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NGDN (23938897 - 23979071 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NGDN: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NGDN |
|
Disorders
/ Diseases
for NGDN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NGDN for disorders About GeneDecksing
OMIM gene information: 610777
OMIM disorders: --
1  disease for NGDN: About MalaCardsgastric dilatation
Export disorders for NGDN gene to outside databases
|
Publications
for NGDN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NGDN gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with NGDN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. (PubMed id 16705177)1, 3 Jung M.Y....Richter J.D. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. (PubMed id 22727665)1 Udagawa T....Richter J.D. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage. (PubMed id 18547334)1 Sihn C.R....Kim S.H. (2008)
|
External Searches for NGDN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NGDN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NGDN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NGDN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NGDN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NGDN gene:
Search GeneIP for patents involving NGDN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NGDN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NGDN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NGDN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NGDN | | | OriGene Protein Over-expression Lysate for NGDN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NGDN | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NGDN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NGDN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NGDN | | OriGene Custom Protein Services for NGDN | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NGDN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NGDN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NGDN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NGDN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NGDN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NGDN |
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| | | | Search Tocris compounds for NGDN |
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 | | | NGDN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NGDN |
|  |  |  | | | | Search ThermoFisher Antibodies for NGDN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NGDN |
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