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NGB Gene

protein-coding   GIFtS: 50
GCID: GC14M077731

Neuroglobin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
neuroglobin1 2

External Ids:    HGNC: 140771   Entrez Gene: 581572   Ensembl: ENSG000001655537   OMIM: 6053045   UniProtKB: Q9NPG23   

Export aliases for NGB gene to outside databases

Previous GC identifers: GC14M075237 GC14M071548 GC14M075721 GC14M076801 GC14M057899


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NGB Gene:
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is
highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it
may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NGB Gene:
NGB (neuroglobin) is a protein-coding gene. Diseases associated with NGB include anoxia, and cocaine abuse. GO annotations related to this gene include iron ion binding and oxygen binding.

UniProtKB/Swiss-Prot: NGB_HUMAN, Q9NPG2
Function: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of
oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated
form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase.
Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the
trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NGB gene promoter:
         MIF-1   GATA-1   Evi-1   c-Ets-1   CREB   AREB6   HEN1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNGB promoter sequence
   Search Chromatin IP Primers for NGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

NGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NGB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077731:  view genomic region     (about GC identifiers)

Start:
77,731,826 bp from pter      End:
77,737,655 bp from pter
Size:
5,830 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NGB_HUMAN, Q9NPG2 (See protein sequence)
Recommended Name: Neuroglobin  
Size: 151 amino acids; 16933 Da
Subunit: Monomer. Homodimer and homotetramer; disulfide-linked (By similarity). Interacts with 14-3-3
2 PDB 3D structures from and Proteopedia for NGB:
1OJ6 (3D)        4MPM (3D)    

Explore the universe of human proteins at neXtProt for NGB: NX_Q9NPG2

Explore proteomics data for NGB at MOPED

Post-translational modifications: 

  • A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO1
  • Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite
    reductase activity1
  • Modification sites at neXtProt

  • See NGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067080.1  
    ENSEMBL proteins: 
     ENSP00000298352  

    NGB Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for NGB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012292 Globin_dom
     IPR009050 Globin-like
     IPR000971 Globin

    Graphical View of Domain Structure for InterPro Entry Q9NPG2

    ProtoNet protein and cluster: Q9NPG2

    2 Blocks protein domains:
    IPB001032 Leghaemoglobin
    IPB013316 Worm globin signature


    UniProtKB/Swiss-Prot: NGB_HUMAN, Q9NPG2
    Similarity: Belongs to the globin family


    NGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NGB_HUMAN, Q9NPG2
    Function: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of
    oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated
    form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase.
    Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the
    trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005344oxygen transporter activity TAS11029004
    GO:0005506iron ion binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--
         
    NGB for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ngb):
     behavior/neurological  mortality/aging  no phenotypic analysis 

    NGB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ngbtm1.2Geno for NGB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NGB
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    hsa-miR-140-3p hsa-miR-3622b-3p hsa-miR-1324 hsa-miR-548s hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidNGB 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NGB_HUMAN, Q9NPG2: Perikaryon (By similarity). Cytoplasm. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005833hemoglobin complex ----
    GO:0043204perikaryon IEA--

    NGB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NGB
    Interactions:

        GeneGlobe Interaction Network for NGB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for NGB (Q9NPG23 ENSP000002983524) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206379O759553, ENSP000003728734I2D: score=2 STRING: ENSP00000372873
    FLOT1O759553, ENSP000003655694I2D: score=2 STRING: ENSP00000365569
    ENSG00000206480O759553I2D: score=2 
    ENSG00000230143O759553I2D: score=2 
    ENSG00000232280O759553I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0015671oxygen transport NAS11029004

    NGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NGB

    2 HMDB Compounds for NGB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for NGB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for NGB gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fe2+ 75 30 18599123 (5), 14645216 (2), 16684569 (2), 18481280 (2) (see all 16)
    oxygen 63.5 88 19001220 (3), 17532579 (3), 17151062 (3), 16179526 (2) (see all 48)
    histidine 60.9 20 16201751 (5), 15036292 (1), 15819897 (1), 18767815 (1) (see all 9)
    peroxynitrite 37.6 3 15020597 (2), 16055362 (1)
    nitric oxide 33.9 30 16223709 (3), 15488767 (2), 18599123 (2), 19651791 (2) (see all 11)
    gdp 24.4 12 12860983 (3), 17337004 (2), 17077295 (1)
    nadh 22.1 2 19782043 (1), 18198128 (1)
    iron 18.9 6 16825958 (2), 15819897 (1), 15020597 (1), 18406335 (1)
    cysteine 18.6 4 14530264 (2), 15122877 (1), 19919085 (1)
    h2o2 13.8 12 18083144 (4), 15020597 (1), 17600531 (1)



    NGB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NGB gene: 
    NM_021257.3  

    Unigene Cluster for NGB:

    Neuroglobin
    Hs.274363  [show with all ESTs]
    Unigene Representative Sequence: AF422797
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000298352(uc001xtg.1)
    miRNA
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    hsa-miR-140-3p hsa-miR-3622b-3p hsa-miR-1324 hsa-miR-548s hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidNGB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF422797.1 AJ245946.1 AK098350.1 AK315395.1 BC032509.1 

    1 DOTS entry:

    DT.432598 

    23 AceView cDNA sequences:

    F13069 AK098350 AJ245946 Z39252 BC032509 BU740886 CR600399 F10663 
    BM727420 BI918146 BX422833 NM_021257 AF422797 BI919200 R36571 AW962007 
    AA324100 R17762 BQ188209 AV723469 BE674160 BF510662 AI381340 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATAAAC
    NGB Expression
    About this image

    NGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274363

    UniProtKB/Swiss-Prot: NGB_HUMAN, Q9NPG2
    Tissue specificity: Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the
    subthalamic nucleus and the thalamus

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NGB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ngb1 , 5 neuroglobin1, 5 88.52(n)1
    94.04(a)1
      12 (41.29 cM)5
    642421  NM_022414.21  NP_071859.11 
     870975315 
    chicken
    (Gallus gallus)
    Aves NGB1 neuroglobin 75.84(n)
    70.47(a)
      428896  NM_001031551.1  NP_001026722.1 
    lizard
    (Anolis carolinensis)
    Reptilia NGB6
    neuroglobin
    61(a)
    1 ↔ 1
    1(20850258-20871863)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ngb1 neuroglobin 65.29(n)
    69.66(a)
      594898  NM_001030351.1  NP_001025522.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ315610.12   -- 76.22(n)   117233  AJ315610.1 


    ENSEMBL Gene Tree for NGB (if available)
    TreeFam Gene Tree for NGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NGB (see all 152)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289099691,2
    C,F--77732623(-) TTACCT/-TTTTT 1 -- ut316Minor allele frequency- -:0.03NS NA 192
    rs1114939381,2
    F--77733139(+) ATTGAA/GTCCAT 1 -- int11Minor allele frequency- G:0.40CSA 5
    rs1151169281,2
    C,F--77733193(+) GTGTCT/CACCTT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1846478681,2
    --77733332(+) CAGACC/TTGAGT 1 -- int10--------
    rs1890656971,2
    --77733463(+) ACCTCC/TCTGAG 1 -- int10--------
    rs1814100891,2
    --77733529(+) GTTGGA/GATGAT 1 -- int10--------
    rs289886251,2
    C,F--77733567(-) ATGCTG/ATGCTA 1 -- int16Minor allele frequency- A:0.04NS WA 304
    rs1502122391,2
    --77733665(+) GACCAC/GTTGAG 1 -- int10--------
    rs1387304531,2
    --77733702(+) AACATA/GGGAAA 1 -- int10--------
    rs289886241,2
    C,F--77733856(-) CCTAGG/CCTGGA 1 -- int17Minor allele frequency- C:0.02NS NA 308

    HapMap Linkage Disequilibrium report for NGB (77731826 - 77737655 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NGB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1739588CNV Deletion17803354
    esv2748901CNV Deletion23290073
    nsv1361CNV Loss18451855
    nsv902104CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605304    OMIM disorders: --

    18 diseases for NGB:    
    About MalaCards
    anoxia    cocaine abuse    traumatic brain injury    arteriovenous malformation
    neuroendocrine carcinoma    brain injury    small cell carcinoma    neurofibromatosis
    hypoxia    ischemia    glaucoma    dementia
    astrocytoma    neuroblastoma    cerebritis    retinitis
    hiv-1    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NGB:
    Cerebrovascular accident

    NGB for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NGB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemia 23.2 10 19751675 (1), 18302932 (1), 18416560 (1), 15637820 (1) (see all 9)
    stroke 9.59 17 20075359 (5), 19087291 (2), 17077295 (1), 11755622 (1) (see all 7)

    Genetic Association Database (GAD): NGB
    Human Genome Epidemiology (HuGE) Navigator: NGB (3 documents)

    Export disorders for NGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NGB gene, integrated from 10 sources (see all 166):
    (articles sorted by number of sources associating them with NGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A vertebrate globin expressed in the brain. (PubMed id 11029004)1, 2, 3, 9 Burmester T.... Hankeln T. (Nature 2000)
    2. Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin. (PubMed id 11820779)1, 2, 9 Zhang C.G.... He F.C. (Biochem. Biophys. Res. Commun. 2002)
    3. Zebrafish neuroglobin is a cell-membrane-penetrating globin. (PubMed id 18416560)1, 2, 9 Watanabe S. and Wakasugi K. (Biochemistry 2008)
    4. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. (PubMed id 11473128)1, 2, 9 Dewilde S.... Moens L. (J. Biol. Chem. 2001)
    5. Association between Ngb polymorphisms and ischemic stroke in the Southern Chinese Han population. (PubMed id 19087291)1, 4, 9 Lin Y....Wu Z.Y. (BMC Med. Genet. 2008)
    6. Coupling of the heme and an internal disulfide bond in human neuroglobin. (PubMed id 15036292)1, 2, 9 Hamdane D.... Marden M.C. (Micron 2004)
    7. Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. (PubMed id 12962627)1, 2, 9 Pesce A.... Bolognesi M. (Structure 2003)
    8. Human neuroglobin functions as a redox-regulated nitrite reductase. (PubMed id 21296891)1, 2 Tiso M.... Gladwin M.T. (J. Biol. Chem. 2011)
    9. 14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide. (PubMed id 21965683)1, 2 Jayaraman T.... Gladwin M.T. (J. Biol. Chem. 2011)
    10. A role for human neuroglobin in apoptosis. (PubMed id 21190290)1, 2 Brittain T.... Raychaudhuri S. (IUBMB Life 2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58157 HGNC: 14077 AceView: NGB Ensembl:ENSG00000165553 euGenes: HUgn58157
    ECgene: NGB H-InvDB: NGB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NGB Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Neuroglobin

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