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Aliases for NGB Gene

Aliases for NGB Gene

  • Neuroglobin 2 3

External Ids for NGB Gene

Summaries for NGB Gene

Entrez Gene Summary for NGB Gene

  • This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGB Gene

NGB (Neuroglobin) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxygen binding.

UniProtKB/Swiss-Prot for NGB Gene

  • Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGB Gene

Genomics for NGB Gene

Genomic Location for NGB Gene

Start:
77,265,483 bp from pter
End:
77,271,312 bp from pter
Size:
5,830 bases
Orientation:
Minus strand

Genomic View for NGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGB Gene

Regulatory Elements for NGB Gene

Proteins for NGB Gene

  • Protein details for NGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG2-NGB_HUMAN
    Recommended name:
    Neuroglobin
    Protein Accession:
    Q9NPG2
    Secondary Accessions:

    Protein attributes for NGB Gene

    Size:
    151 amino acids
    Molecular mass:
    16933 Da
    Quaternary structure:
    • Monomer. Homodimer and homotetramer; disulfide-linked (By similarity). Interacts with 14-3-3.

    Three dimensional structures from OCA and Proteopedia for NGB Gene

neXtProt entry for NGB Gene

Proteomics data for NGB Gene at MOPED

Post-translational modifications for NGB Gene

  • A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO
  • Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.

Other Protein References for NGB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NGB Gene

Domains for NGB Gene

Protein Domains for NGB Gene

UniProtKB/Swiss-Prot:

NGB_HUMAN
Family:
  • Belongs to the globin family.:
    • Q9NPG2
genes like me logo Genes that share domains with NGB: view

No data available for Gene Families for NGB Gene

Function for NGB Gene

Molecular function for NGB Gene

UniProtKB/Swiss-Prot Function: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

Gene Ontology (GO) - Molecular Function for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005344 oxygen transporter activity TAS 11029004
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0019825 oxygen binding --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with NGB: view
genes like me logo Genes that share phenotypes with NGB: view

Animal Models for NGB Gene

MGI Knock Outs for NGB:
  • Ngb tm1.2Geno

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NGB Gene

Localization for NGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGB Gene

Perikaryon. Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGB Gene COMPARTMENTS Subcellular localization image for NGB gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with NGB: view

Pathways for NGB Gene

SuperPathways for NGB Gene

No Data Available

Gene Ontology (GO) - Biological Process for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0015671 oxygen transport NAS 11029004
genes like me logo Genes that share ontologies with NGB: view

No data available for Pathways by source for NGB Gene

Compounds for NGB Gene

(2) HMDB Compounds for NGB Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Oxygen
  • Oxygen
7782-44-7

(1) Drugbank Compounds for NGB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Heme
target

(14) Novoseek inferred chemical compound relationships for NGB Gene

Compound -log(P) Hits PubMed IDs
fe2+ 75 24
oxygen 63.5 65
histidine 60.9 13
peroxynitrite 37.6 3
nitric oxide 33.9 16
genes like me logo Genes that share compounds with NGB: view

Transcripts for NGB Gene

mRNA/cDNA for NGB Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NGB Gene

Neuroglobin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NGB Gene

No ASD Table

Relevant External Links for NGB Gene

GeneLoc Exon Structure for
NGB
ECgene alternative splicing isoforms for
NGB

Expression for NGB Gene

mRNA expression in normal human tissues for NGB Gene

mRNA differential expression in normal tissues according to GTEx for NGB Gene

This gene is overexpressed in Brain - Hypothalamus (15.1), Brain - Cortex (8.3), Brain - Frontal Cortex (BA9) (7.2), and Pituitary (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NGB Gene

SOURCE GeneReport for Unigene cluster for NGB Gene Hs.274363

mRNA Expression by UniProt/SwissProt for NGB Gene

Q9NPG2-NGB_HUMAN
Tissue specificity: Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.
genes like me logo Genes that share expressions with NGB: view

Orthologs for NGB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NGB 36
  • 99.78 (n)
  • 100 (a)
NGB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NGB 36
  • 92.94 (n)
  • 96.69 (a)
NGB 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGB 36
  • 91.39 (n)
  • 95.36 (a)
NGB 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngb 36
  • 88.52 (n)
  • 94.04 (a)
Ngb 16
Ngb 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NGB 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGB 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngb 36
  • 87.2 (n)
  • 94.04 (a)
chicken
(Gallus gallus)
Aves NGB 36
  • 75.84 (n)
  • 70.47 (a)
NGB 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGB 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngb 36
  • 65.29 (n)
  • 69.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7992 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
ngb 36
  • 62 (n)
  • 56 (a)
ngb 37
  • 50 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YHB1 39
Species with no ortholog for NGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGB Gene

ENSEMBL:
Gene Tree for NGB (if available)
TreeFam:
Gene Tree for NGB (if available)

Paralogs for NGB Gene

No data available for Paralogs for NGB Gene

Variants for NGB Gene

Sequence variations from dbSNP and Humsavar for NGB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1306963 -- 77,269,784(+) CTCTC(C/T)CTCTC intron-variant
rs1306964 -- 77,269,790(+) CTCTC(C/T)CTCTC intron-variant
rs1600005 -- 77,269,931(+) gcccg(A/G)ggagg intron-variant
rs3783988 -- 77,268,237(-) TTAAC(A/G)AGCTT intron-variant
rs3783989 -- 77,267,900(-) GCTTG(C/T)ATCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NGB Gene

Variant ID Type Subtype PubMed ID
nsv1361 CNV Loss 18451855
nsv902104 CNV Loss 21882294
esv2748901 CNV Deletion 23290073
esv1739588 CNV Deletion 17803354

Relevant External Links for NGB Gene

HapMap Linkage Disequilibrium report
NGB

Disorders for NGB Gene

(1) University of Copenhagen DISEASES for NGB Gene

(2) Novoseek inferred disease relationships for NGB Gene

Disease -log(P) Hits PubMed IDs
ischemia 23.2 9
stroke 9.59 12

Relevant External Links for NGB

Genetic Association Database (GAD)
NGB
Human Genome Epidemiology (HuGE) Navigator
NGB
genes like me logo Genes that share disorders with NGB: view

No data available for UniProtKB/Swiss-Prot for NGB Gene

Publications for NGB Gene

  1. A vertebrate globin expressed in the brain. (PMID: 11029004) Burmester T. … Hankeln T. (Nature 2000) 2 3 4 23
  2. Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin. (PMID: 11820779) Zhang C.G. … He F.C. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  3. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. (PMID: 11473128) Dewilde S. … Moens L. (J. Biol. Chem. 2001) 3 4 23
  4. Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. (PMID: 12962627) Pesce A. … Bolognesi M. (Structure 2003) 3 4 23
  5. Coupling of the heme and an internal disulfide bond in human neuroglobin. (PMID: 15036292) Hamdane D. … Marden M.C. (Micron 2004) 3 4 23

Products for NGB Gene

Sources for NGB Gene

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