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Aliases for NGB Gene

Aliases for NGB Gene

  • Neuroglobin 2 3 5

External Ids for NGB Gene

Previous GeneCards Identifiers for NGB Gene

  • GC14M075237
  • GC14M071548
  • GC14M075721
  • GC14M076801
  • GC14M077731
  • GC14M057899

Summaries for NGB Gene

Entrez Gene Summary for NGB Gene

  • This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]

GeneCards Summary for NGB Gene

NGB (Neuroglobin) is a Protein Coding gene. Diseases associated with NGB include stroke, ischemic. GO annotations related to this gene include iron ion binding and oxygen binding.

UniProtKB/Swiss-Prot for NGB Gene

  • Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NGB Gene

Genomics for NGB Gene

Regulatory Elements for NGB Gene

Genomic Location for NGB Gene

Chromosome:
14
Start:
77,265,483 bp from pter
End:
77,271,312 bp from pter
Size:
5,830 bases
Orientation:
Minus strand

Genomic View for NGB Gene

Genes around NGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NGB Gene

Proteins for NGB Gene

  • Protein details for NGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG2-NGB_HUMAN
    Recommended name:
    Neuroglobin
    Protein Accession:
    Q9NPG2

    Protein attributes for NGB Gene

    Size:
    151 amino acids
    Molecular mass:
    16933 Da
    Quaternary structure:
    • Monomer. Homodimer and homotetramer; disulfide-linked (By similarity). Interacts with 14-3-3.

    Three dimensional structures from OCA and Proteopedia for NGB Gene

neXtProt entry for NGB Gene

Proteomics data for NGB Gene at MOPED

Post-translational modifications for NGB Gene

  • A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
  • Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.

Other Protein References for NGB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NGB Gene

Domains & Families for NGB Gene

Protein Domains for NGB Gene

Suggested Antigen Peptide Sequences for NGB Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPG2

UniProtKB/Swiss-Prot:

NGB_HUMAN :
  • Belongs to the globin family.
Family:
  • Belongs to the globin family.
genes like me logo Genes that share domains with NGB: view

No data available for Gene Families for NGB Gene

Function for NGB Gene

Molecular function for NGB Gene

UniProtKB/Swiss-Prot Function:
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

Gene Ontology (GO) - Molecular Function for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005344 oxygen transporter activity TAS 11029004
GO:0005515 protein binding IPI 25416956
GO:0019825 oxygen binding IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with NGB: view
genes like me logo Genes that share phenotypes with NGB: view

Animal Models for NGB Gene

MGI Knock Outs for NGB:
  • Ngb tm1.2Geno

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NGB Gene

Localization for NGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NGB Gene

Perikaryon. Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NGB Gene COMPARTMENTS Subcellular localization image for NGB gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 3
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NGB: view

Pathways & Interactions for NGB Gene

SuperPathways for NGB Gene

No Data Available

Gene Ontology (GO) - Biological Process for NGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015671 oxygen transport NAS 11029004
genes like me logo Genes that share ontologies with NGB: view

No data available for Pathways by source and SIGNOR curated interactions for NGB Gene

Drugs & Compounds for NGB Gene

(6) Drugs for NGB Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(9) Additional Compounds for NGB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with NGB: view

Transcripts for NGB Gene

mRNA/cDNA for NGB Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NGB Gene

Neuroglobin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NGB Gene

No ASD Table

Relevant External Links for NGB Gene

GeneLoc Exon Structure for
NGB
ECgene alternative splicing isoforms for
NGB

Expression for NGB Gene

mRNA expression in normal human tissues for NGB Gene

mRNA differential expression in normal tissues according to GTEx for NGB Gene

This gene is overexpressed in Brain - Hypothalamus (x15.1), Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x7.2), and Pituitary (x4.5).

Protein differential expression in normal tissues from HIPED for NGB Gene

This gene is overexpressed in Colon (55.5) and Rectum (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NGB Gene



SOURCE GeneReport for Unigene cluster for NGB Gene Hs.274363

mRNA Expression by UniProt/SwissProt for NGB Gene

Q9NPG2-NGB_HUMAN
Tissue specificity: Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.
genes like me logo Genes that share expression patterns with NGB: view

Protein tissue co-expression partners for NGB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NGB Gene

Orthologs for NGB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NGB 35
  • 92.94 (n)
  • 96.69 (a)
NGB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NGB 35
  • 91.39 (n)
  • 95.36 (a)
NGB 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ngb 35
  • 88.52 (n)
  • 94.04 (a)
Ngb 16
Ngb 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NGB 35
  • 99.78 (n)
  • 100 (a)
NGB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ngb 35
  • 87.2 (n)
  • 94.04 (a)
oppossum
(Monodelphis domestica)
Mammalia NGB 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NGB 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NGB 35
  • 75.84 (n)
  • 70.47 (a)
NGB 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NGB 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ngb 35
  • 65.29 (n)
  • 69.66 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ngb 35
  • 62 (n)
  • 56 (a)
ngb 36
  • 50 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7992 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YHB1 38
Species with no ortholog for NGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NGB Gene

ENSEMBL:
Gene Tree for NGB (if available)
TreeFam:
Gene Tree for NGB (if available)

Paralogs for NGB Gene

No data available for Paralogs for NGB Gene

Variants for NGB Gene

Sequence variations from dbSNP and Humsavar for NGB Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1306963 -- 77,269,784(+) CTCTC(C/T)CTCTC intron-variant
rs1306964 -- 77,269,790(+) CTCTC(C/T)CTCTC intron-variant
rs1600005 -- 77,269,931(+) gcccg(A/G)ggagg intron-variant
rs3783988 -- 77,268,237(-) TTAAC(A/G)AGCTT intron-variant
rs3783989 -- 77,267,900(-) GCTTG(C/T)ATCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NGB Gene

Variant ID Type Subtype PubMed ID
nsv1361 CNV Loss 18451855
nsv902104 CNV Loss 21882294
esv2748901 CNV Deletion 23290073
esv1739588 CNV Deletion 17803354

Variation tolerance for NGB Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NGB Gene

HapMap Linkage Disequilibrium report
NGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NGB Gene

Disorders for NGB Gene

MalaCards: The human disease database

(1) MalaCards diseases for NGB Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
stroke, ischemic
  • ischemic stroke
- elite association - COSMIC cancer census association via MalaCards
Search NGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for NGB

Genetic Association Database (GAD)
NGB
Human Genome Epidemiology (HuGE) Navigator
NGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NGB
genes like me logo Genes that share disorders with NGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NGB Gene

Publications for NGB Gene

  1. A vertebrate globin expressed in the brain. (PMID: 11029004) Burmester T. … Hankeln T. (Nature 2000) 2 3 4 23 67
  2. Neuroglobin expression in ischemic stroke. (PMID: 20075359) Jin K. … Greenberg D.A. (Stroke 2010) 3 23
  3. Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. (PMID: 20091232) Raychaudhuri S. … Brittain T. (Apoptosis 2010) 3 23
  4. Expression and hypoxic up-regulation of neuroglobin in human glioblastoma cells. (PMID: 19383366) Emara M. … Allalunis-Turner J. (Mol Oncol 2009) 3 23
  5. Unusual stability of human neuroglobin at low pH--molecular mechanisms and biological significance. (PMID: 19860834) Picotti P. … Fontana A. (FEBS J. 2009) 3 23

Products for NGB Gene

Sources for NGB Gene

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