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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFYC Gene

protein-coding   GIFtS: 57
GCID: GC01P041159

nuclear transcription factor Y, gamma
 Explore 6 diseases affiliated with
NFYC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NFYC    

Aliases
for NFYC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Transcription Factor Y, Gamma1 2     HAP52
NF-YC1 2 3     HSM2
CBF-C1 2     CCAAT Binding Factor Subunit C2
Nuclear Transcription Factor Y Subunit C2 3     CCAAT Transcription Binding Factor Subunit Gamma2
Transactivator HSM-1/22 3     Histone H1 Transcription Factor Large Subunit 2A2
CAAT Box DNA-Binding Protein Subunit C2 3     Nuclear Transcription Factor Y Subunit Gamma2
CBFC2 5     Transactivator HSM-12
H1TF2A2     Transcription Factor NF-Y, C Subunit2

External Ids:    HGNC: 78061   Entrez Gene: 48022   Ensembl: ENSG000000661367   OMIM: 6053445   UniProtKB: Q139523   

Export aliases for NFYC gene to outside databases

Previous GC identifers: GC01P041192 GC01P040160 GC01P040620 GC01P040570 GC01P040533 GC01P040826 GC01P040929 GC01P039275


Summaries
for NFYC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NFYC:
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with
high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight
dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high
specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for
example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYC


Genomic Views
for NFYC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFYC gene promoter:
         Sp1   NRSF form 1   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NFYC promoter sequence
   Search SABiosciences Chromatin IP Primers for NFYC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p32

NFYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P041159:  view genomic region     (about GC identifiers)

Start:
 41,157,242 bp from pter      End:
 41,237,275 bp from pter
Size:
 80,034 bases      Orientation:
 plus strand

Proteins
for NFYC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit gamma  
Size: 458 amino acids; 50302 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must
interact and dimerize for NF-YA association and DNA binding
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for NFYC:
1N1J (3D)        4AWL (3D)    
Secondary accessions: B4DUS6 B4DW63 D3DPV9 Q5T6K8 Q5T6K9 Q5T6L1 Q5TZR6 Q92869 Q9HBX1 Q9NXB5 Q9UM67
Q9UML0 Q9UMT7
Alternative splicing: 6 isoforms:  Q13952-1   Q13952-2   Q13952-3   Q13952-4   Q13952-5   Q13952-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFYC: NX_Q13952

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13952

    • NFYC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001136059.1  NP_001136060.1  NP_001136061.1  NP_001136062.1  NP_055038.2  

    ENSEMBL proteins: 
     ENSP00000408315   ENSP00000404427   ENSP00000396620   ENSP00000397647   ENSP00000408867  
     ENSP00000361738   ENSP00000433820   ENSP00000361737   ENSP00000361754   ENSP00000361736  
     ENSP00000361734   ENSP00000434404   ENSP00000414299   ENSP00000436710   ENSP00000433413  
     ENSP00000409219   ENSP00000312617   ENSP00000416403  
    Reactome Protein details: Q13952
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: NFYC
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    Novus Biologicals NFYC Proteins
    Novus Biologicals NFYC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NFYC

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA15964792
    GO:0016602CCAAT-binding factor complex IDA15243141


    NFYC for ontologies           About GeneDecksing



    NFYC Antibody Products: 
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    Assay Products for NFYC: 
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    Uscn ELISAs and CLIAs for NFYC

    Protein Domains /
    Families
    for NFYC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NFYC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003958 CBFA_NFYB_domain
     IPR009072 Histone-fold
     IPR027170 NFYC/HAP5_su

    Graphical View of Domain Structure for InterPro Entry Q13952

    ProtoNet protein and cluster: Q13952

    1 Blocks protein family: IPB003958 Transcription factor CBF/NF-Y/archaeal histone

    UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952
    Similarity: Belongs to the NFYC/HAP5 subunit family


    Function
    for NFYC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for
    example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYC:
    nuclear transcription factor NF-Y,C subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs,in a
    variety of promoters,similarity with H2A

    10/233 SABiosciences Target genes for NFYC (see all 233):
    ABI3 ACSL3 ADNP2 ADORA2B AGBL5 AGPAT5 AKAP9 ALPK2 ALS2CR12 ANKRD37

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 5): NFYC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFYC
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate NFYC (see all 20):
    hsa-miR-596 hsa-miR-137 hsa-miR-3616-5p hsa-miR-25 hsa-miR-199b-5p hsa-miR-3662 hsa-miR-33b hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmid: NFYC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFYC (see all 7)
    OriGene shRNA RFP: NFYC
    OriGene siRNA: NFYC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFYC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NFYC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFYC (see all 7)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYC 

    Cell Line
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    Search LifeMap BioReagents cell lines for NFYC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYC

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS10446203
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--


    NFYC for ontologies           About GeneDecksing



    Pathways & Interactions
    for NFYC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of Mevalonate Kinase (MVK)
    		Expression of Mevalonate Kinase (MVK)1.00
    		Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)0.75
    		Expression of 7-Dehydrocholesterol Reductase (DHCR7)0.75
    		Expression of Phosphomevalonate Kinase (PMVK)0.75
    		Expression of Lanosterol Demethylase (CYP51A1)0.75
    		Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)0.75
    		Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)0.75
    		Expression of Fatty Acid Synthase (FASN)0.62
    2Expression of Lathosterol Oxidase (SC5D, SC5DL)
    		Expression of Lathosterol Oxidase (SC5D, SC5DL)1.00
    		Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)0.71
    		Expression of Farnesyl Diphosphate Synthase (FDPS)0.71
    		Expression of Squalene Monooxygenase (SQLE)0.71
    		Expression of TM7SF20.71
    		Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)0.57
    		Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)0.71
    3Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    4Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    		Regulation of Cholesterol Biosynthesis by SREBP (SREBF)1.00
    		Activation of Gene Expression by SREBP (SREBF)0.67
    5Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for NFYC 
        TGF-beta Receptor Signaling Pathway
    Validated targets of C-MYC transcriptional repression
    Direct p53 effectors

    5/22        Reactome Pathways for NFYC (see all 22)
        Expression of Fatty Acid Synthase (FASN)
    Expression of Mevalonate Kinase (MVK)
    Expression of Squalene Monooxygenase (SQLE)
    Metabolism
    Expression of 7-Dehydrocholesterol Reductase (DHCR7)


    2         Kegg Pathways  (Kegg details for NFYC):
        Antigen processing and presentation
    Tuberculosis


    NFYC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFYC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/98 Interacting proteins for NFYC (Q139521, 2, 3 ENSP000003966204) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFYBP252081, 2, 3, ENSP000002400554EBI-389755,EBI-389728 MINT-25006 I2D: score=7 STRING: ENSP00000240055
    GAPDHP044062, 3, ENSP000002292394MINT-8256371 I2D: score=2 STRING: ENSP00000229239
    NFYAP235111, 3, ENSP000003457024EBI-389755,EBI-389739 I2D: score=4 STRING: ENSP00000345702
    ATF6P188503, ENSP000003569194I2D: score=4 STRING: ENSP00000356919
    ARID2Q68CP93, ENSP000003350444I2D: score=3 STRING: ENSP00000335044
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA15243141
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10446203
    GO:0006457protein folding TAS10446203
    GO:0045893positive regulation of transcription, DNA-dependent IEA--


    NFYC for ontologies           About GeneDecksing



    Drugs & Compounds
    for NFYC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFYC
    Search CenterWatch for drugs/clinical trials and news about NFYC 

    Transcripts
    for NFYC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NFYC gene (5 alternative transcripts): 
    NM_001142587.1  NM_001142588.1  NM_001142589.1  NM_001142590.1  NM_014223.4  

    Unigene Cluster for NFYC:

    Nuclear transcription factor Y, gamma
    Hs.713051  [show with all ESTs]
    Unigene Representative Sequence: AK055329
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000467203 ENST00000424419(uc010ojm.1) ENST00000427410 ENST00000447388(uc001cfx.4 uc009vwd.3 uc001cfz.3 uc010ojn.2 uc001cfy.4)
    ENST00000425457 ENST00000453631 ENST00000456393 ENST00000372654 ENST00000534399
    ENST00000372653(uc001cgc.3) ENST00000372669 ENST00000372652(uc001cgb.3)
    ENST00000372651 ENST00000531464 ENST00000440226 ENST00000525290 ENST00000530965
    ENST00000416859

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFYC
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate NFYC (see all 20):
    hsa-miR-596 hsa-miR-137 hsa-miR-3616-5p hsa-miR-25 hsa-miR-199b-5p hsa-miR-3662 hsa-miR-33b hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmid: NFYC 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFYC (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFYC

    Additional cDNA sequence: 

    AB208975.1 AF191744.1 AK000346.1 AK055329.1 AK093786.1 AK126386.1 AK127677.1 AK300774.1 
    AK301215.1 AK301385.1 AL713771.1 BC005003.1 BT020081.1 D85425.1 D89986.1 U62296.1 
    U78774.1 Z70024.1 Z74792.1 

    20 DOTS entries:

    DT.100712314  DT.100823613  DT.450364  DT.95304933  DT.100036901  DT.100823620  DT.121375603  DT.86841732 
    DT.97775683  DT.100823614  DT.97862124  DT.95185771  DT.101984405  DT.121375560  DT.428282  DT.100823619 
    DT.121375553  DT.40117139  DT.100823611  DT.121375548 

    24/367 AceView cDNA sequences (see all 367):

    BM683810 CR590607 BE885872 AA442448 AI623580 CA432482 AI740810 CR601428 
    BE811714 BM505044 BE207914 CA428288 AU133467 BM915566 CB854839 BQ231989 
    AK000346 AL549307 AA317484 BU632858 W73611 BU729678 AI696898 BQ012815 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NFYC (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16
    SP1:                                                        -           -     -                       -     -     -     -           -     -         
    SP2:              -     -     -                             -           -                             -     -     -     -           -               
    SP3:                    -     -                             -           -                             -     -     -     -           -     -         
    SP4:        -     -     -     -                             -           -                             -     -     -     -           -     -         
    SP5:                                                        -           -                             -           -     -           -               


    ECgene alternative splicing isoforms for NFYC

    Expression
    for NFYC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFYC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATGCAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NFYC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFYC

    SOURCE GeneReport for Unigene cluster: Hs.713051
        SABiosciences Custom PCR Arrays for NFYC
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    Orthologs
    for NFYC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYC gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nfyc1 , 5 nuclear transcription factor-Y gamma1, 5 92.74(n)1
    99.4(a)1    		   4 (56.52 cM)5
    180461  NM_008692.31  NP_032718.21 
     1207574385 
    chicken
    (Gallus gallus)    		 Aves NFYC1 nuclear transcription factor Y, gamma 84.65(n)
    96.04(a)    		   419642  XM_001233265.2  XP_001233266.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 89(a)
    87(a)
    		 many → 1
    many → 1
    		 GL343308.1(243962-260520)
    4(119865302-119866294)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.67522 Xenopus laevis nuclear Y/CCAAT-box binding factor C more 73.56(n)    AF041205.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb98f012 wufb98f01 81.75(n)   323445  BC045364.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG30753
    Nf-YC1    		 transcription factor3
    Nuclear factor Y-box C1    		 60(a)3
    46.77(n)1
    38.44(a)1    		   6D33
    316221  NM_132126.21  NP_572354.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea nfyc-16
    		 Nuclear transcription Factor Y, C (gamma) subunit ...
    		 21(a)
    		 1 ↔ 1
    		 II(43880-44981)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NF-YC26
    NF-YC36
    (see all 10)    		 nuclear transcription factor Y subunit C-3
    (see all 10)    		 43(a)
    37(a)
    (see all 10)    		 possible ortholog
    possible ortholog
    (see all 10)    		 1(21024764-21025883)
    1(20451083-20452671)
    rice
    (Oryza sativa)    		 Liliopsida Os.245662 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.56(n)    AK105079.1 


    ENSEMBL Gene Tree for NFYC (if available)
    TreeFam Gene Tree for NFYC (if available) 

    Paralogs
    for NFYC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFYC gene
    POLE42  
    13 SIMAP similar genes for NFYC using alignment to 10 protein entries:     NFYC_HUMAN (see all proteins):
    DKFZp667G242    hCBF-C    KIAA1651    SH2B3    pp12301    COQ5
    TUBA1C    NCKAP1L    SNRPF    LOC100996300    ATF1    POLE4
    CHRAC1

    NFYC for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NFYC
    PGOHUM00000236237 PGOHUM00000241701


    Genomic Variants
    for NFYC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1363 NCBI SNPs in NFYC are shown (see all 1363)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1859907401,2
    		--41155382(+) AAGGGC/G/TGGAGG 6 -- us2k1 nc-transcript-variant0--------
    rs27809521,2
    		C,F,A,H,--41155383(+) AGGGCA/GGAGGC 5 -- us2k1 nc-transcript-variant17Minor allele frequency- G:0.26NA WA CSA EA 515
    rs747188131,2
    		F,--41155463(+) TAACAT/CTGACT 5 -- us2k1 nc-transcript-variant1Minor allele frequency- C:0.03WA 118
    rs27448011,2
    		C,F,A,--41155486(-) CTAGAG/ATATTT 5 -- nc-transcript-variantus2k112Minor allele frequency- A:0.29NA WA CSA EA 376
    rs1441528581,2
    		--41155513(+) GCTGCG/TGTCCC 5 -- us2k1 nc-transcript-variant0--------
    rs1509737211,2
    		--41155599(+) ACCTAA/GCACAG 5 -- us2k1 nc-transcript-variant0--------
    rs782942211,2
    		--41155730(+) TTATTT/CCTGAG 6 -- nc-transcript-variantus2k12Minor allele frequency- C:0.10CSA WA 120
    rs791257291,2
    		--41155760(+) TCTTGG/CAAGGA 6 -- us2k1 nc-transcript-variant1Minor allele frequency- C:0.01WA 118
    rs1921488631,2
    		--41155784(+) CCCTAA/GGTGTG 6 -- us2k1 nc-transcript-variant0--------
    rs1839647691,2
    		--41155805(+) AATTAC/TAACAA 6 -- nc-transcript-variantus2k10--------

    HapMap Linkage Disequilibrium report for NFYC (41157242 - 41237275 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NFYC
         1 Indel: 59928

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    Disorders / Diseases
    for NFYC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NFYC for disorders           About GeneDecksing

    OMIM gene information: 605344    OMIM disorders: --

    6 diseases for NFYC:    About MalaCards
    renal cell carcinoma    lung carcinoma    prostate cancer    carcinoma
    prostatitis    tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: NFYC (4 documents)

    Export disorders for NFYC gene to outside databases

    Publications
    for NFYC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFYC gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with NFYC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human NF-YC. (PubMed id 9249075)1, 2, 3, 9 Bellorini M....Mantovani R. (1997)
    2. Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. (PubMed id 8921405)1, 3, 9 Sinha S....de Crombrugghe B. (1996)
    3. Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. (PubMed id 9332362)1, 2, 9 Dmitrenko V.V.... Kavsan V.M. (1997)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. (PubMed id 12401788)1, 2 Romier C.... Moras D. (2003)
    8. Cell cycle-dependent switch of up- and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. (PubMed id 10446203)1, 2 Taira T.... Ariga H. (1999)
    9. Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox. (PubMed id 8910521)1, 2 Nakshatri H.... Currie R.A. (1996)
    10. NF-YC complexity is generated by dual promoters and a lternative splicing. (PubMed id 19690168)1, 9 Ceribelli M....Mantovani R. (2009)

    External Searches for NFYC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NFYC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4802 HGNC: 7806 AceView: NFYC Ensembl:ENSG00000066136 euGenes: HUgn4802
    ECgene: NFYC Kegg: 4802 H-InvDB: NFYC

    Other Databases showing NFYC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NFYC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFYC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NFYC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFYC gene:
    Search GeneIP for patents involving NFYC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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