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NFYC Gene

protein-coding   GIFtS: 58
GCID: GC01P041159

Nuclear Transcription Factor Y, Gamma

  Search for NFYC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Transcription Factor Y, Gamma1 2     HAP52
Nuclear Transcription Factor Y Subunit C2 3     HSM2
Transactivator HSM-1/22 3     CCAAT Binding Factor Subunit C2
NF-YC2 3     CCAAT Transcription Binding Factor Subunit Gamma2
CAAT Box DNA-Binding Protein Subunit C2 3     Histone H1 Transcription Factor Large Subunit 2A2
CBFC2 5     Nuclear Transcription Factor Y Subunit Gamma2
CBF-C2     Transactivator HSM-12
H1TF2A2     Transcription Factor NF-Y, C Subunit2

External Ids:    HGNC: 78061   Entrez Gene: 48022   Ensembl: ENSG000000661367   OMIM: 6053445   UniProtKB: Q139523   

Export aliases for NFYC gene to outside databases

Previous GC identifers: GC01P041192 GC01P040160 GC01P040620 GC01P040570 GC01P040533 GC01P040826 GC01P040929 GC01P039275


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFYC Gene:
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds
with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C,
forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to
DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for NFYC Gene:
NFYC (nuclear transcription factor Y, gamma) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POLE4.

UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
for example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NFYC gene promoter:
         Sp1   NRSF form 1   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NFYC promoter sequence
   Search Chromatin IP Primers for NFYC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p32

NFYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P041159:  view genomic region     (about GC identifiers)

Start:
41,157,242 bp from pter      End:
41,237,275 bp from pter
Size:
80,034 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit gamma  
Size: 458 amino acids; 50302 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC
must interact and dimerize for NF-YA association and DNA binding
Sequence caution: Sequence=BAD92212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for NFYC:
1N1J (3D)        4AWL (3D)    
Secondary accessions: B4DUS6 B4DW63 D3DPV9 F8VWM3 Q59GY4 Q5T6K8 Q5T6K9 Q5T6L1 Q5TZR6 Q92869
Q9HBX1 Q9NXB5 Q9UM67 Q9UML0 Q9UMT7
Alternative splicing: 7 isoforms:  Q13952-1   Q13952-2   Q13952-3   Q13952-4   Q13952-5   Q13952-6   Q13952-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFYC: NX_Q13952

Explore proteomics data for NFYC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys71, Lys92
  • Modification sites at PhosphoSitePlus

  • See NFYC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001136059.1  NP_001136060.1  NP_001136061.1  NP_001136062.1  NP_055038.2  

    ENSEMBL proteins: 
     ENSP00000408315   ENSP00000404427   ENSP00000396620   ENSP00000397647   ENSP00000408867  
     ENSP00000361738   ENSP00000433820   ENSP00000361737   ENSP00000361754   ENSP00000361736  
     ENSP00000361734   ENSP00000434404   ENSP00000414299   ENSP00000436710   ENSP00000433413  
     ENSP00000409219   ENSP00000312617   ENSP00000416403  
    Reactome Protein details: Q13952

    NFYC Human Recombinant Protein Products:

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    Novus Biologicals NFYC Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR003958 CBFA_NFYB_domain
     IPR027170 NFYC/HAP5_su

    Graphical View of Domain Structure for InterPro Entry Q13952

    ProtoNet protein and cluster: Q13952

    1 Blocks protein domain: IPB003958 Transcription factor CBF/NF-Y/archaeal histone

    UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952
    Similarity: Belongs to the NFYC/HAP5 subunit family


    Find genes that share domains with NFYC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFYC_HUMAN, Q13952
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
    for example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYC:
    nuclear transcription factor NF-Y,C subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs,in a
    variety of promoters,similarity with H2A

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS10446203
    GO:0005515protein binding IPI12401788
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with NFYC           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFYC
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFYC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFYC

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NFYC (see all 225):
    ABI3,  ACSL3,  ADNP2,  ADORA2B,  AGBL5,  AGPAT5,  AKAP9,  ALPK2,  ALS2CR12,  ANKRD37

    miRNA
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    hsa-mir-33a-5p (MIRT007356), hsa-mir-221-3p (MIRT046926), hsa-mir-155-5p (MIRT020636)

    Block miRNA regulation of human, mouse, rat NFYC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFYC (see all 20):
    hsa-miR-596 hsa-miR-137 hsa-miR-3616-5p hsa-miR-25 hsa-miR-199b-5p hsa-miR-3662 hsa-miR-33b hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidNFYC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFYC
    Predesigned siRNA for gene silencing in human, mouse, rat NFYC

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 5): NFYC (NM_014223)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFYC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYC

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NFYC 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFYC_HUMAN, Q13952: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    chloroplast1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0016602CCAAT-binding factor complex IDA15243141

    Find genes that share ontologies with NFYC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NFYC About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by ATF6-alpha0.00
    Activation of Chaperones by ATF6-alpha0.00
    3PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    4Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with NFYC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NFYC
        TGF-beta Receptor Signaling Pathway
    Direct p53 effectors
    Validated targets of C-MYC transcriptional repression

    4 Reactome Pathways for NFYC
        PPARA activates gene expression
    ATF6-alpha activates chaperone genes
    Activation of gene expression by SREBF (SREBP)
    ATF4 activates genes


    2 Kegg Pathways  (Kegg details for NFYC):
        Antigen processing and presentation
    Tuberculosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NFYC
    Interactions:

        GeneGlobe Interaction Network for NFYC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFYC (Q139521, 2, 3 ENSP000003966204) via UniProtKB, MINT, STRING, and/or I2D (see all 148)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFYBP252081, 2, 3, ENSP000002400554EBI-389755,EBI-389728 MINT-25006 I2D: score=7 STRING: ENSP00000240055
    GAPDHP044062, 3, ENSP000002292394MINT-8256371 I2D: score=2 STRING: ENSP00000229239
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA15243141
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10446203
    GO:0006457protein folding TAS10446203
    GO:0044255cellular lipid metabolic process TAS--

    Find genes that share ontologies with NFYC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFYC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NFYC gene (5 alternative transcripts): 
    NM_001142587.1  NM_001142588.1  NM_001142589.1  NM_001142590.1  NM_014223.4  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000467203 ENST00000424419(uc010ojm.1) ENST00000427410 ENST00000447388(uc001cfx.4 uc009vwd.3 uc001cfz.3 uc010ojn.2 uc001cfy.4)
    ENST00000425457 ENST00000453631 ENST00000456393 ENST00000372654 ENST00000534399
    ENST00000372653(uc001cgc.3) ENST00000372669 ENST00000372652(uc001cgb.3)
    ENST00000372651 ENST00000531464 ENST00000440226 ENST00000525290 ENST00000530965
    ENST00000416859
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    Selected qRT-PCR Assays for microRNAs that regulate NFYC (see all 20):
    hsa-miR-596 hsa-miR-137 hsa-miR-3616-5p hsa-miR-25 hsa-miR-199b-5p hsa-miR-3662 hsa-miR-33b hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidNFYC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NFYC
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): NFYC (NM_014223)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFYC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYC
    Primer
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    OriGene qPCR primer pairs and template standards for NFYC
    OriGene qSTAR qPCR primer pairs in human, mouse for NFYC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFYC
      QuantiTect SYBR Green Assays in human, mouse, rat NFYC
      QuantiFast Probe-based Assays in human, mouse, rat NFYC

    Selected AceView cDNA sequences (see all 367):

    BQ775255 BQ772293 AU132177 BM505044 AL537754 CA432482 AU124641 BU632858 
    AA317484 AL549307 AW293992 AU125743 CR601428 Z41425 AI673129 AI740810 
    AI911195 AW512248 AI623580 CA487701 BM930346 AU133467 CA428491 CF265135 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFYC (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16
    SP1:                                                        -           -     -                       -     -     -     -           -     -         
    SP2:              -     -     -                             -           -                             -     -     -     -           -               
    SP3:                    -     -                             -           -                             -     -     -     -           -     -         
    SP4:        -     -     -     -                             -           -                             -     -     -     -           -     -         
    SP5:                                                        -           -                             -           -     -           -               


    ECgene alternative splicing isoforms for NFYC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NFYC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCAATA
    NFYC Expression
    About this image

    NFYC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFYC Protein Expression
        Custom PCR Arrays for NFYC
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NFYC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYC gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfyc1 , 5 nuclear transcription factor-Y gamma1, 5 92.74(n)1
    99.4(a)1
      4 (56.52 cM)5
    180461  NM_008692.41  NP_032718.21 
     1207574385 
    chicken
    (Gallus gallus)
    Aves NFYC1 nuclear transcription factor Y, gamma 84.73(n)
    96.11(a)
      419642  XM_004947796.1  XP_004947853.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    94(a)
    88(a)
    many → 1
    many → 1
    GL343308.1(221509-262619)
    4(119865302-119866294)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.67522 Xenopus laevis nuclear Y/CCAAT-box binding factor C more 73.56(n)    AF041205.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb98f012 wufb98f01 81.75(n)   323445  BC045364.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG30753 transcription factor 60(a)   6D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea nfyc-16
    Protein NFYC-1 (nfyc-1) mRNA, complete cds
    19(a)
    many ↔ many
    II(43880-44981) WBGene00017742
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAP56
    Subunit of the heme-activated, glucose-repressed H...
    26(a)
    1 → many
    XV(1010161-1010889) YOR358W
    soybean
    (Glycine max)
    eudicotyledons Gma.78262 Transcribed sequence with moderate similarity to protein more 74.85(n)    BI321875.1 
    rice
    (Oryza sativa)
    Liliopsida Os.245662 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.56(n)    AK105079.1 


    ENSEMBL Gene Tree for NFYC (if available)
    TreeFam Gene Tree for NFYC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFYC gene
    POLE42  
    11 SIMAP similar genes for NFYC using alignment to 9 protein entries:     NFYC_HUMAN (see all proteins):
    DKFZp667G242    hCBF-C    KIAA1651    SH2B3    pp12301    COQ5
    TUBA1C    SNRPF    ATF1    POLE4    CHRAC1

    Find genes that share paralogs with NFYC           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NFYC
    PGOHUM00000236237 PGOHUM00000241701


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFYC (see all 1149)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357024
    A breast cancer sample4--see VAR_0357022 Q H mis40--------
    rs787251581,2
    C,F--41159950(+) GATATG/ACTTAT 5 -- int11Minor allele frequency- A:0.02EA 120
    rs1500955341,2
    C--41159960(+) TCCTGA/GACAAT 5 -- int10--------
    rs767574531,2
    C,F--41159964(+) GAACAA/GTGTGT 5 -- int11Minor allele frequency- G:0.02NA 120
    rs1810273191,2
    --41160017(+) TTGCAC/TGGAAA 5 -- int10--------
    rs789328851,2
    C,F--41160024(+) GAAACC/TTTTAA 5 -- int11Minor allele frequency- T:0.02NA 120
    rs1871749571,2
    --41160060(+) AGTTGA/GAAATC 5 -- int10--------
    rs1458582421,2
    --41160084(+) GTCTTA/GATGTG 5 -- int10--------
    rs1909089761,2
    --41160123(+) TTACAA/GTAACG 5 -- int10--------
    rs75193481,2
    C,F,A,H--41160204(+) ATTTCG/AGCCTC 5 -- int129Minor allele frequency- A:0.35NS EA NA WA CSA 2774

    HapMap Linkage Disequilibrium report for NFYC (41157242 - 41237275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NFYC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663905CNV Deletion23128226
    nsv610CNV Insertion18451855
    esv8923CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFYC
    DNA2.0 Custom Variant and Variant Library Synthesis for NFYC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605344    OMIM disorders: --


    Find genes that share disorders with NFYC           About GenesLikeMe

    Genetic Association Database (GAD): NFYC
    Human Genome Epidemiology (HuGE) Navigator: NFYC (4 documents)

    Export disorders for NFYC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFYC gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with NFYC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human NF-YC. (PubMed id 9249075)1, 2, 3, 9 Bellorini M....Mantovani R. (Gene 1997)
    2. Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. (PubMed id 8921405)1, 3, 9 Sinha S....de Crombrugghe B. (Genomics 1996)
    3. Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. (PubMed id 9332362)1, 2, 9 Dmitrenko V.V.... Kavsan V.M. (Gene 1997)
    4. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PubMed id 23332751)1, 2 Nardini M.... Mantovani R. (Cell 2013)
    5. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1, 4 Ramsuran V....Ndung'u T. (Clin. Infect. Dis. 2011)
    6. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (Clin. Cancer Res. 2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. (PubMed id 12401788)1, 2 Romier C.... Moras D. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4802 HGNC: 7806 AceView: NFYC Ensembl:ENSG00000066136 euGenes: HUgn4802
    ECgene: NFYC Kegg: 4802 H-InvDB: NFYC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NFYC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFYC gene:
    Search GeneIP for patents involving NFYC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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