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Aliases for NFYC Gene

Aliases for NFYC Gene

  • Nuclear Transcription Factor Y Subunit Gamma 2 3 5
  • Nuclear Transcription Factor Y Subunit C 3 4
  • CAAT Box DNA-Binding Protein Subunit C 3 4
  • Nuclear Transcription Factor Y, Gamma 2 3
  • Transactivator HSM-1/2 3 4
  • NF-YC 3 4
  • CCAAT Transcription Binding Factor Subunit Gamma 3
  • Histone H1 Transcription Factor Large Subunit 2A 3
  • Transcription Factor NF-Y, C Subunit 3
  • CCAAT Binding Factor Subunit C 3
  • Transactivator HSM-1 3
  • H1TF2A 3
  • CBF-C 3
  • CBFC 3
  • HAP5 3
  • HSM 3

External Ids for NFYC Gene

Previous GeneCards Identifiers for NFYC Gene

  • GC01P041192
  • GC01P040160
  • GC01P040620
  • GC01P040570
  • GC01P040533
  • GC01P040826
  • GC01P040929
  • GC01P039275
  • GC01P041159

Summaries for NFYC Gene

Entrez Gene Summary for NFYC Gene

  • This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for NFYC Gene

NFYC (Nuclear Transcription Factor Y Subunit Gamma) is a Protein Coding gene. Among its related pathways are Allograft rejection and Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is POLE4.

UniProtKB/Swiss-Prot for NFYC Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYC Gene

Additional gene information for NFYC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYC Gene

Genomics for NFYC Gene

Regulatory Elements for NFYC Gene

Enhancers for NFYC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H039851 1.3 ENCODE dbSUPER 19.4 -839.2 -839175 1 HNRNPUL1 PKNOX1 FOXA2 MLX ARID4B FEZF1 ZNF2 YY1 MXD4 REST TRIT1 PPIE MYCBP NFYC RLF EXO5 RRAGC LOC101929516 SNORA55 PPIEL
GH01H040372 1.8 FANTOM5 ENCODE dbSUPER 13.3 -315.7 -315718 5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF766 PPIEL PPIE TRIT1 EXO5 SMAP2 ENSG00000259943 ENSG00000182109 RLF NFYC-AS1 LOC105378674
GH01H040906 0.8 dbSUPER 23.4 +215.5 215473 1 ELF3 SOX13 FOXA2 ZFP64 ZNF140 ZNF266 CEBPG ZNF697 RARA ZNF433 EXO5 NFYC ENSG00000259943 CITED4 RLF MIR30C1 MIR30E NFYC-AS1 LOC105378672 PIR51186
GH01H040872 1.5 Ensembl ENCODE dbSUPER 11.8 +184.2 184216 6 HDGF TCF12 GTF3C2 GLIS2 GATA2 FOS RUNX3 SMARCB1 ZNF592 SMARCA4 TRIT1 EXO5 NFYC KCNQ4 CITED4 ENSG00000229528 PIR44205
GH01H041238 1.4 Ensembl ENCODE 11.8 +549.6 549554 5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YBX1 YY1 SLC30A9 EXO5 ENSG00000235358 FOXO6 NFYC SCMH1 CTPS1 PIR51229
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFYC on UCSC Golden Path with GeneCards custom track

Promoters for NFYC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005237 430 2001 ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 GLIS1 NBN

Genomic Location for NFYC Gene

Chromosome:
1
Start:
40,691,570 bp from pter
End:
40,771,603 bp from pter
Size:
80,034 bases
Orientation:
Plus strand

Genomic View for NFYC Gene

Genes around NFYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYC Gene

Proteins for NFYC Gene

  • Protein details for NFYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13952-NFYC_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit gamma
    Protein Accession:
    Q13952
    Secondary Accessions:
    • B4DUS6
    • B4DW63
    • D3DPV9
    • F8VWM3
    • Q59GY4
    • Q5T6K8
    • Q5T6K9
    • Q5T6L1
    • Q5TZR6
    • Q92869
    • Q9HBX1
    • Q9NXB5
    • Q9UM67
    • Q9UML0
    • Q9UMT7

    Protein attributes for NFYC Gene

    Size:
    458 amino acids
    Molecular mass:
    50302 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.
    SequenceCaution:
    • Sequence=BAD92212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYC Gene

    Alternative splice isoforms for NFYC Gene

neXtProt entry for NFYC Gene

Post-translational modifications for NFYC Gene

  • Ubiquitination at posLast=3636, posLast=7171, and posLast=9292
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NFYC Gene

Domains & Families for NFYC Gene

Gene Families for NFYC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

Q13952

UniProtKB/Swiss-Prot:

NFYC_HUMAN :
  • Belongs to the NFYC/HAP5 subunit family.
Family:
  • Belongs to the NFYC/HAP5 subunit family.
genes like me logo Genes that share domains with NFYC: view

Function for NFYC Gene

Molecular function for NFYC Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,C subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs,in a variety of promoters,similarity with H2A
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Phenotypes From GWAS Catalog for NFYC Gene

Gene Ontology (GO) - Molecular Function for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 11256944
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA,IDA 15243141
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9332362
genes like me logo Genes that share ontologies with NFYC: view
genes like me logo Genes that share phenotypes with NFYC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NFYC

CRISPR Products

miRNA for NFYC Gene

miRTarBase miRNAs that target NFYC

Transcription Factor Targets for NFYC Gene

Selected GeneGlobe predicted Target genes for NFYC

Clone Products

  • Applied Biological Materials Clones for NFYC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYC Gene

Localization for NFYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYC gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15243141
GO:0005654 nucleoplasm TAS,IDA --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
GO:0090575 RNA polymerase II transcription factor complex IDA 11256944
genes like me logo Genes that share ontologies with NFYC: view

Pathways & Interactions for NFYC Gene

genes like me logo Genes that share pathways with NFYC: view

Gene Ontology (GO) - Biological Process for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10446203
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006457 protein folding TAS 10446203
genes like me logo Genes that share ontologies with NFYC: view

No data available for SIGNOR curated interactions for NFYC Gene

Drugs & Compounds for NFYC Gene

No Compound Related Data Available

Transcripts for NFYC Gene

Unigene Clusters for NFYC Gene

Nuclear transcription factor Y, gamma:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NFYC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NFYC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: -
SP7:
SP8:
SP9: -
SP10: - -

Relevant External Links for NFYC Gene

GeneLoc Exon Structure for
NFYC
ECgene alternative splicing isoforms for
NFYC

Expression for NFYC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFYC Gene

Protein differential expression in normal tissues from HIPED for NFYC Gene

This gene is overexpressed in Ovary (8.7) and Oral epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFYC Gene



NURSA nuclear receptor signaling pathways regulating expression of NFYC Gene:

NFYC

SOURCE GeneReport for Unigene cluster for NFYC Gene:

Hs.713051

Evidence on tissue expression from TISSUES for NFYC Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Intestine(3.8)
  • Stomach(3.6)
  • Kidney(3.5)
  • Eye(2.9)
  • Liver(2.7)
  • Muscle(2.4)
  • Pancreas(2.3)
  • Heart(2.2)
  • Spleen(2.2)
  • Blood(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with NFYC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFYC Gene

Orthologs for NFYC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYC 33 34
  • 99.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFYC 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFYC 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYC 33 34
  • 95.21 (n)
dog
(Canis familiaris)
Mammalia NFYC 33 34
  • 94.81 (n)
mouse
(Mus musculus)
Mammalia Nfyc 33 16 34
  • 92.74 (n)
rat
(Rattus norvegicus)
Mammalia Nfyc 33
  • 91.94 (n)
chicken
(Gallus gallus)
Aves NFYC 33 34
  • 84.73 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nfyc 33
  • 79.34 (n)
MGC75886 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6752 33
zebrafish
(Danio rerio)
Actinopterygii nfyc 33 34
  • 77.98 (n)
wufb98f01 33
fruit fly
(Drosophila melanogaster)
Insecta CG3075 35
  • 60 (a)
Nf-YC 34
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfyc-1 34
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP5 34
  • 26 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.7826 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1103 33
barley
(Hordeum vulgare)
Liliopsida Hv.10173 33
rice
(Oryza sativa)
Liliopsida Os.24566 33
wheat
(Triticum aestivum)
Liliopsida Ta.7755 33
corn
(Zea mays)
Liliopsida Zm.17510 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12254 33
Species where no ortholog for NFYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYC Gene

ENSEMBL:
Gene Tree for NFYC (if available)
TreeFam:
Gene Tree for NFYC (if available)

Paralogs for NFYC Gene

Paralogs for NFYC Gene

Pseudogenes.org Pseudogenes for NFYC Gene

genes like me logo Genes that share paralogs with NFYC: view

Variants for NFYC Gene

Sequence variations from dbSNP and Humsavar for NFYC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035702 A breast cancer sample
rs1000013139 -- 40,716,985(+) AGATT(A/C/T)GATTT intron-variant
rs1000025325 -- 40,761,170(+) AGTAC(A/C)GTGAT intron-variant
rs1000043897 -- 40,769,491(+) TTGGA(A/T)GGTTA intron-variant
rs1000059839 -- 40,747,009(+) TGTTG(C/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFYC Gene

Variant ID Type Subtype PubMed ID
esv2663905 CNV deletion 23128226
esv3577821 CNV loss 25503493
esv3577822 CNV loss 25503493
esv8923 CNV gain 19470904
nsv1137251 CNV deletion 24896259
nsv610 CNV insertion 18451855

Variation tolerance for NFYC Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYC Gene

Disorders for NFYC Gene

Relevant External Links for NFYC

Genetic Association Database (GAD)
NFYC
Human Genome Epidemiology (HuGE) Navigator
NFYC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYC

No disorders were found for NFYC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYC Gene

Publications for NFYC Gene

  1. Cloning and expression of human NF-YC. (PMID: 9249075) Bellorini M … Mantovani R (Gene 1997) 2 3 4 22 60
  2. Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. (PMID: 9332362) Dmitrenko V … Kavsan V (Gene 1997) 3 4 22 60
  3. Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. (PMID: 8921405) Sinha S … de Crombrugghe B (Genomics 1996) 2 3 22 60
  4. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M … Mantovani R (Cell 2013) 3 4 60
  5. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V … Ndung'u T (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011) 3 45 60

Products for NFYC Gene

Sources for NFYC Gene

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