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Aliases for NFYC Gene

Aliases for NFYC Gene

  • Nuclear Transcription Factor Y Subunit Gamma 2 3 5
  • Nuclear Transcription Factor Y Subunit C 3 4
  • CAAT Box DNA-Binding Protein Subunit C 3 4
  • Nuclear Transcription Factor Y, Gamma 2 3
  • Transactivator HSM-1/2 3 4
  • NF-YC 3 4
  • CCAAT Transcription Binding Factor Subunit Gamma 3
  • Histone H1 Transcription Factor Large Subunit 2A 3
  • Transcription Factor NF-Y, C Subunit 3
  • CCAAT Binding Factor Subunit C 3
  • Transactivator HSM-1 3
  • H1TF2A 3
  • CBF-C 3
  • CBFC 3
  • HAP5 3
  • HSM 3

External Ids for NFYC Gene

Previous GeneCards Identifiers for NFYC Gene

  • GC01P041192
  • GC01P040160
  • GC01P040620
  • GC01P040570
  • GC01P040533
  • GC01P040826
  • GC01P040929
  • GC01P039275
  • GC01P041159

Summaries for NFYC Gene

Entrez Gene Summary for NFYC Gene

  • This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for NFYC Gene

NFYC (Nuclear Transcription Factor Y Subunit Gamma) is a Protein Coding gene. Among its related pathways are Tuberculosis and Unfolded Protein Response (UPR). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is POLE4.

UniProtKB/Swiss-Prot for NFYC Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYC Gene

Genomics for NFYC Gene

Regulatory Elements for NFYC Gene

Enhancers for NFYC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NFYC on UCSC Golden Path with GeneCards custom track

Promoters for NFYC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NFYC Gene

Chromosome:
1
Start:
40,691,570 bp from pter
End:
40,771,603 bp from pter
Size:
80,034 bases
Orientation:
Plus strand

Genomic View for NFYC Gene

Genes around NFYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYC Gene

Proteins for NFYC Gene

  • Protein details for NFYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13952-NFYC_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit gamma
    Protein Accession:
    Q13952
    Secondary Accessions:
    • B4DUS6
    • B4DW63
    • D3DPV9
    • F8VWM3
    • Q59GY4
    • Q5T6K8
    • Q5T6K9
    • Q5T6L1
    • Q5TZR6
    • Q92869
    • Q9HBX1
    • Q9NXB5
    • Q9UM67
    • Q9UML0
    • Q9UMT7

    Protein attributes for NFYC Gene

    Size:
    458 amino acids
    Molecular mass:
    50302 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.
    SequenceCaution:
    • Sequence=BAD92212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYC Gene

    Alternative splice isoforms for NFYC Gene

neXtProt entry for NFYC Gene

Post-translational modifications for NFYC Gene

  • Ubiquitination at Lys 36, Lys 71, and Lys 92
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NFYC Gene

Domains & Families for NFYC Gene

Protein Domains for NFYC Gene

Graphical View of Domain Structure for InterPro Entry

Q13952

UniProtKB/Swiss-Prot:

NFYC_HUMAN :
  • Belongs to the NFYC/HAP5 subunit family.
Family:
  • Belongs to the NFYC/HAP5 subunit family.
genes like me logo Genes that share domains with NFYC: view

No data available for Gene Families for NFYC Gene

Function for NFYC Gene

Molecular function for NFYC Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,C subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs,in a variety of promoters,similarity with H2A
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Ontology (GO) - Molecular Function for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IDA 15243141
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9332362
GO:0003713 transcription coactivator activity TAS 10446203
genes like me logo Genes that share ontologies with NFYC: view
genes like me logo Genes that share phenotypes with NFYC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NFYC

CRISPR Products

miRNA for NFYC Gene

miRTarBase miRNAs that target NFYC

Transcription Factor Targets for NFYC Gene

Selected GeneGlobe predicted Target genes for NFYC

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYC Gene

Localization for NFYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFYC Gene COMPARTMENTS Subcellular localization image for NFYC gene
Compartment Confidence
nucleus 5
cytosol 2
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15243141
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
genes like me logo Genes that share ontologies with NFYC: view

Pathways & Interactions for NFYC Gene

genes like me logo Genes that share pathways with NFYC: view

Gene Ontology (GO) - Biological Process for NFYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10446203
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006457 protein folding TAS 10446203
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NFYC: view

No data available for SIGNOR curated interactions for NFYC Gene

Drugs & Compounds for NFYC Gene

No Compound Related Data Available

Transcripts for NFYC Gene

Unigene Clusters for NFYC Gene

Nuclear transcription factor Y, gamma:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFYC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: -
SP7:
SP8:
SP9: -
SP10: - -

Relevant External Links for NFYC Gene

GeneLoc Exon Structure for
NFYC
ECgene alternative splicing isoforms for
NFYC

Expression for NFYC Gene

mRNA expression in normal human tissues for NFYC Gene

Protein differential expression in normal tissues from HIPED for NFYC Gene

This gene is overexpressed in Ovary (8.7) and Oral epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFYC Gene



NURSA nuclear receptor signaling pathways regulating expression of NFYC Gene:

NFYC

SOURCE GeneReport for Unigene cluster for NFYC Gene:

Hs.713051
genes like me logo Genes that share expression patterns with NFYC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NFYC Gene

Orthologs for NFYC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFYC 34
  • 95.21 (n)
  • 99.4 (a)
NFYC 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFYC 34
  • 94.81 (n)
  • 99.1 (a)
NFYC 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfyc 34
  • 92.74 (n)
  • 99.4 (a)
Nfyc 16
Nfyc 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFYC 34
  • 99.7 (n)
  • 100 (a)
NFYC 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfyc 34
  • 91.94 (n)
  • 99.4 (a)
oppossum
(Monodelphis domestica)
Mammalia NFYC 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFYC 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFYC 34
  • 84.73 (n)
  • 96.11 (a)
NFYC 35
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75886 34
nfyc 34
  • 79.34 (n)
  • 90.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6752 34
zebrafish
(Danio rerio)
Actinopterygii nfyc 34
  • 77.98 (n)
  • 88.38 (a)
wufb98f01 34
nfyc 35
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3075 36
  • 60 (a)
Nf-YC 35
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfyc-1 35
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP5 35
  • 26 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.7826 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1103 34
barley
(Hordeum vulgare)
Liliopsida Hv.10173 34
rice
(Oryza sativa)
Liliopsida Os.24566 34
wheat
(Triticum aestivum)
Liliopsida Ta.7755 34
corn
(Zea mays)
Liliopsida Zm.17510 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12254 34
Species where no ortholog for NFYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYC Gene

ENSEMBL:
Gene Tree for NFYC (if available)
TreeFam:
Gene Tree for NFYC (if available)

Paralogs for NFYC Gene

Paralogs for NFYC Gene

Pseudogenes.org Pseudogenes for NFYC Gene

genes like me logo Genes that share paralogs with NFYC: view

Variants for NFYC Gene

Sequence variations from dbSNP and Humsavar for NFYC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035702 A breast cancer sample
rs1494 -- 40,706,176(-) TTTCC(A/G)CTGCA intron-variant
rs475268 -- 40,713,183(-) GGAAG(C/T)CCTAA intron-variant
rs650949 -- 40,714,937(+) tagcc(A/G)ggtgt intron-variant
rs569159 -- 40,701,862(-) CTCCA(C/T)CGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFYC Gene

Variant ID Type Subtype PubMed ID
esv2663905 CNV deletion 23128226
esv3577821 CNV loss 25503493
esv3577822 CNV loss 25503493
esv8923 CNV gain 19470904
nsv1137251 CNV deletion 24896259
nsv610 CNV insertion 18451855

Variation tolerance for NFYC Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYC Gene

Disorders for NFYC Gene

Relevant External Links for NFYC

Genetic Association Database (GAD)
NFYC
Human Genome Epidemiology (HuGE) Navigator
NFYC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYC

No disorders were found for NFYC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYC Gene

Publications for NFYC Gene

  1. Cloning and expression of human NF-YC. (PMID: 9249075) Bellorini M. … Mantovani R. (Gene 1997) 2 3 4 22 65
  2. Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. (PMID: 9332362) Dmitrenko V.V. … Kavsan V.M. (Gene 1997) 3 4 22 65
  3. Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. (PMID: 8921405) Sinha S. … de Crombrugghe B. (Genomics 1996) 2 3 22 65
  4. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M. … Mantovani R. (Cell 2013) 3 4 65
  5. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V. … Ndung'u T. (Clin. Infect. Dis. 2011) 3 46 65

Products for NFYC Gene

Sources for NFYC Gene

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