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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFYC Gene

protein-coding   GIFtS: 60
GCID: GC01P041159

Nuclear Transcription Factor Y, Gamma

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Transcription Factor Y, Gamma1 2     HAP52
Nuclear Transcription Factor Y Subunit C2 3     HSM2
Transactivator HSM-1/22 3     CCAAT Binding Factor Subunit C2
NF-YC2 3     CCAAT Transcription Binding Factor Subunit Gamma2
CAAT Box DNA-Binding Protein Subunit C2 3     Histone H1 Transcription Factor Large Subunit 2A2
CBFC2 5     Nuclear Transcription Factor Y Subunit Gamma2
CBF-C2     Transactivator HSM-12
H1TF2A2     Transcription Factor NF-Y, C Subunit2

External Ids:    HGNC: 78061   Entrez Gene: 48022   Ensembl: ENSG000000661367   OMIM: 6053445   UniProtKB: Q139523   

Export aliases for NFYC gene to outside databases

Previous GC identifers: GC01P041192 GC01P040160 GC01P040620 GC01P040570 GC01P040533 GC01P040826 GC01P040929 GC01P039275


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFYC Gene:
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds
with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C,
forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to
DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for NFYC Gene: 
NFYC (nuclear transcription factor Y, gamma) is a protein-coding gene. Diseases associated with NFYC include renal cell carcinoma, and tuberculosis, and among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Activation of Gene Expression by SREBP (SREBF). GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POLE4.

UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
for example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFYC gene promoter:
         Sp1   NRSF form 1   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NFYC promoter sequence
   Search SABiosciences Chromatin IP Primers for NFYC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p32

NFYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P041159:  view genomic region     (about GC identifiers)

Start:
41,157,242 bp from pter      End:
41,237,275 bp from pter
Size:
80,034 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit gamma  
Size: 458 amino acids; 50302 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC
must interact and dimerize for NF-YA association and DNA binding
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for NFYC:
1N1J (3D)        4AWL (3D)    
Secondary accessions: B4DUS6 B4DW63 D3DPV9 F8VWM3 Q59GY4 Q5T6K8 Q5T6K9 Q5T6L1 Q5TZR6 Q92869
Q9HBX1 Q9NXB5 Q9UM67 Q9UML0 Q9UMT7
Alternative splicing: 7 isoforms:  Q13952-1   Q13952-2   Q13952-3   Q13952-4   Q13952-5   Q13952-6   Q13952-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFYC: NX_Q13952

Explore proteomics data for NFYC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13952

  • NFYC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NFYC Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001136059.1  NP_001136060.1  NP_001136061.1  NP_001136062.1  NP_055038.2  

    ENSEMBL proteins: 
     ENSP00000408315   ENSP00000404427   ENSP00000396620   ENSP00000397647   ENSP00000408867  
     ENSP00000361738   ENSP00000433820   ENSP00000361737   ENSP00000361754   ENSP00000361736  
     ENSP00000361734   ENSP00000434404   ENSP00000414299   ENSP00000436710   ENSP00000433413  
     ENSP00000409219   ENSP00000312617   ENSP00000416403  
    Reactome Protein details: Q13952
    Human Recombinant Protein Products for NFYC: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA15243141
    GO:0005654nucleoplasm TAS--
    GO:0016602CCAAT-binding factor complex IDA15243141

    NFYC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR003958 CBFA_NFYB_domain
     IPR027170 NFYC/HAP5_su

    Graphical View of Domain Structure for InterPro Entry Q13952

    ProtoNet protein and cluster: Q13952

    1 Blocks protein domain: IPB003958 Transcription factor CBF/NF-Y/archaeal histone

    UniProtKB/Swiss-Prot: NFYC_HUMAN, Q13952
    Similarity: Belongs to the NFYC/HAP5 subunit family


    NFYC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFYC_HUMAN, Q13952
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
    for example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYC:
    nuclear transcription factor NF-Y,C subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs,in a
    variety of promoters,similarity with H2A

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS10446203
    GO:0005515protein binding IPI12401788
    GO:0043565sequence-specific DNA binding IEA--
         
    NFYC for ontologies           About GeneDecksing


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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFYC 

    10/228 SABiosciences Target genes for NFYC (see all 228):
    ABI3 ACSL3 ADNP2 ADORA2B AGBL5 AGPAT5 AKAP9 ALPK2 ALS2CR12 ANKRD37

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNFYC 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NFYC About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    2Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.67
    Activation of Gene Expression by SREBP (SREBF)0.67
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Allograft rejection
    Antigen processing and presentation0.37
    5Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NFYC
        TGF-beta Receptor Signaling Pathway
    Direct p53 effectors
    Validated targets of C-MYC transcriptional repression

    5/7        Reactome Pathways for NFYC (see all 7)
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    PPARA Activates Gene Expression
    Activation of Gene Expression by SREBP (SREBF)
    Fatty acid, triacylglycerol, and ketone body metabolism


    2         Kegg Pathways  (Kegg details for NFYC):
        Antigen processing and presentation
    Tuberculosis


    NFYC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFYC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/115 Interacting proteins for NFYC (Q139521, 2, 3 ENSP000003966204) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFYBP252081, 2, 3, ENSP000002400554EBI-389755,EBI-389728 MINT-25006 I2D: score=7 STRING: ENSP00000240055
    GAPDHP044062, 3, ENSP000002292394MINT-8256371 I2D: score=2 STRING: ENSP00000229239
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA15243141
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10446203
    GO:0006457protein folding TAS10446203
    GO:0044255cellular lipid metabolic process TAS--

    NFYC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFYC

    Search CenterWatch for drugs/clinical trials and news about NFYC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFYC gene (5 alternative transcripts): 
    NM_001142587.1  NM_001142588.1  NM_001142589.1  NM_001142590.1  NM_014223.4  

    Unigene Cluster for NFYC:

    Nuclear transcription factor Y, gamma
    Hs.713051  [show with all ESTs]
    Unigene Representative Sequence: AK055329
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000467203 ENST00000424419(uc010ojm.1) ENST00000427410 ENST00000447388(uc001cfx.4 uc009vwd.3 uc001cfz.3 uc010ojn.2 uc001cfy.4)
    ENST00000425457 ENST00000453631 ENST00000456393 ENST00000372654 ENST00000534399
    ENST00000372653(uc001cgc.3) ENST00000372669 ENST00000372652(uc001cgb.3)
    ENST00000372651 ENST00000531464 ENST00000440226 ENST00000525290 ENST00000530965
    ENST00000416859
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    Additional mRNA sequence: 

    AB208975.1 AF191744.1 AK000346.1 AK055329.1 AK093786.1 AK126386.1 AK127677.1 AK300774.1 
    AK301215.1 AK301385.1 AL713771.1 BC005003.1 BT020081.1 D85425.1 D89986.1 U62296.1 
    U78774.1 Z70024.1 Z74792.1 

    20 DOTS entries:

    DT.100712314  DT.100823613  DT.450364  DT.95304933  DT.100036901  DT.100823620  DT.121375603  DT.86841732 
    DT.97775683  DT.100823614  DT.97862124  DT.95185771  DT.101984405  DT.121375560  DT.428282  DT.100823619 
    DT.121375553  DT.40117139  DT.100823611  DT.121375548 

    24/367 AceView cDNA sequences (see all 367):

    AI740810 BM930346 CA432482 W73611 CR596697 BI906234 AW071617 BQ446058 
    BQ772293 BE811714 AL549307 AL537754 CR590607 CA428288 AW293992 BF980801 
    BQ682892 CD743024 AU132177 BE207914 AK000346 AW027024 BU729678 BU077462 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NFYC (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16
    SP1:                                                        -           -     -                       -     -     -     -           -     -         
    SP2:              -     -     -                             -           -                             -     -     -     -           -               
    SP3:                    -     -                             -           -                             -     -     -     -           -     -         
    SP4:        -     -     -     -                             -           -                             -     -     -     -           -     -         
    SP5:                                                        -           -                             -           -     -           -               


    ECgene alternative splicing isoforms for NFYC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFYC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCAATA
    NFYC Expression
    About this image


    See NFYC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFYC

    SOURCE GeneReport for Unigene cluster: Hs.713051
        SABiosciences Custom PCR Arrays for NFYC
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYC gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfyc1 , 5 nuclear transcription factor-Y gamma1, 5 92.74(n)1
    99.4(a)1
      4 (56.52 cM)5
    180461  NM_008692.31  NP_032718.21 
     1207574385 
    chicken
    (Gallus gallus)
    Aves NFYC1 nuclear transcription factor Y, gamma 84.65(n)
    96.04(a)
      419642  XM_001233265.2  XP_001233266.2 
    lizard
    (Anolis carolinensis)
    Reptilia NFYC6
    --
    Uncharacterized protein
    94(a)
    86(a)
    1 ↔ 1
    possible ortholog
    GL343308.1(221509-262619)
    4(119865302-119866294)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.67522 Xenopus laevis nuclear Y/CCAAT-box binding factor C more 73.56(n)    AF041205.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb98f012 wufb98f01 81.75(n)   323445  BC045364.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG30753
    Nf-YC1
    transcription factor3
    Nuclear factor Y-box C1
    60(a)3
    46.77(n)1
    38.44(a)1
      6D33
    316221  NM_132126.21  NP_572354.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nfyc-16
    Protein NFYC-1
    23(a)
    1 ↔ 1
    II(43880-44981)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAP56
    Subunit of the heme-activated, glucose-repressed H...
    28(a)
    1 → many
    XV(1010161-1010889)
    soybean
    (Glycine max)
    eudicotyledons Gma.78262 Transcribed sequence with moderate similarity to protein more 74.85(n)    BI321875.1 
    rice
    (Oryza sativa)
    Liliopsida Os.245662 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.56(n)    AK105079.1 


    ENSEMBL Gene Tree for NFYC (if available)
    TreeFam Gene Tree for NFYC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFYC gene
    POLE42  
    11 SIMAP similar genes for NFYC using alignment to 9 protein entries:     NFYC_HUMAN (see all proteins):
    DKFZp667G242    hCBF-C    KIAA1651    SH2B3    pp12301    COQ5
    TUBA1C    SNRPF    ATF1    POLE4    CHRAC1

    NFYC for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NFYC
    PGOHUM00000236237 PGOHUM00000241701


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1149 SNPs in NFYC are shown (see all 1149)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357024
    A breast cancer sample4--see VAR_0357022 Q H mis40--------
    VAR_0594604
    ----see VAR_0594602 T I mis40--------
    rs787251581,2
    C,F--41159950(+) GATATG/ACTTAT 5 -- int11Minor allele frequency- A:0.02EA 120
    rs1500955341,2
    C--41159960(+) TCCTGA/GACAAT 5 -- int10--------
    rs767574531,2
    C,F--41159964(+) GAACAA/GTGTGT 5 -- int11Minor allele frequency- G:0.02NA 120
    rs1810273191,2
    --41160017(+) TTGCAC/TGGAAA 5 -- int10--------
    rs789328851,2
    C,F--41160024(+) GAAACC/TTTTAA 5 -- int11Minor allele frequency- T:0.02NA 120
    rs1871749571,2
    --41160060(+) AGTTGA/GAAATC 5 -- int10--------
    rs1458582421,2
    --41160084(+) GTCTTA/GATGTG 5 -- int10--------
    rs1909089761,2
    --41160123(+) TTACAA/GTAACG 5 -- int10--------

    HapMap Linkage Disequilibrium report for NFYC (41157242 - 41237275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NFYC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663905CNV Deletion23128226
    nsv610CNV Insertion18451855
    esv8923CNV Gain19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605344    OMIM disorders: --

    4 diseases for NFYC:    About MalaCards
    renal cell carcinoma    tuberculosis    prostate cancer    prostatitis


    NFYC for disorders           About GeneDecksing

    Genetic Association Database (GAD): NFYC
    Human Genome Epidemiology (HuGE) Navigator: NFYC (4 documents)

    Export disorders for NFYC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFYC gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with NFYC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human NF-YC. (PubMed id 9249075)1, 2, 3, 9 Bellorini M....Mantovani R. (1997)
    2. Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. (PubMed id 8921405)1, 3, 9 Sinha S....de Crombrugghe B. (1996)
    3. Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. (PubMed id 9332362)1, 2, 9 Dmitrenko V.V.... Kavsan V.M. (1997)
    4. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PubMed id 23332751)1, 2 Nardini M.... Mantovani R. (2013)
    5. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1, 4 Ramsuran V....Ndung'u T. (2011)
    6. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. (PubMed id 12401788)1, 2 Romier C.... Moras D. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4802 HGNC: 7806 AceView: NFYC Ensembl:ENSG00000066136 euGenes: HUgn4802
    ECgene: NFYC Kegg: 4802 H-InvDB: NFYC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFYC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFYC gene:
    Search GeneIP for patents involving NFYC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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