Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NFYB Gene

protein-coding   GIFtS: 62
GCID: GC12M104510

Nuclear Transcription Factor Y, Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Transcription Factor Y, Beta1 2     CBF-A2
Nuclear Transcription Factor Y Subunit B2 3     CBF-B2
HAP32 3     CCAAT-Binding Transcription Factor Subunit A2
NF-YB2 3     Nuclear Transcription Factor Y Subunit Beta2
CAAT Box DNA-Binding Protein Subunit B2 3     Transcription Factor NF-Y, B Subunit2

External Ids:    HGNC: 78051   Entrez Gene: 48012   Ensembl: ENSG000001208377   OMIM: 1899045   UniProtKB: P252083   

Export aliases for NFYB gene to outside databases

Previous GC identifers: GC12M103626 GC12M104393 GC12M103015 GC12M103013 GC12M101570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NFYB Gene:
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription
factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene
product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The
resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like
motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein
sequence alignments and experiments with mutants. (provided by RefSeq, Jul 2008)

GeneCards Summary for NFYB Gene:
NFYB (nuclear transcription factor Y, beta) is a protein-coding gene. Diseases associated with NFYB include osteochondritis dissecans, and cleidocranial dysplasia. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POLE3.

UniProtKB/Swiss-Prot: NFYB_HUMAN, P25208
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
for example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFYB gene promoter:
         HOXA9B   HOXA9   HNF-1   HNF-4alpha2   AP-2gamma   Meis-1b   Meis-1   HNF-1A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFYB promoter sequence
   Search Chromatin IP Primers for NFYB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFYB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22-q23   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q22-q23

NFYB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYB gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M104510:  view genomic region     (about GC identifiers)

Start:
104,510,855 bp from pter      End:
104,532,067 bp from pter
Size:
21,213 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NFYB_HUMAN, P25208 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit beta  
Size: 207 amino acids; 22831 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC
must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP
Sequence caution: Sequence=CAA42230.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for NFYB:
1N1J (3D)        4AWL (3D)    
Secondary accessions: A8K7B9 Q96IY8

Explore the universe of human proteins at neXtProt for NFYB: NX_P25208

Explore proteomics data for NFYB at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of
    histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'1
  • Ubiquitination2 at Lys140
  • Modification sites at PhosphoSitePlus

  • See NFYB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006157.1  
    ENSEMBL proteins: 
     ENSP00000240055   ENSP00000447486   ENSP00000448250  
    Reactome Protein details: P25208

    NFYB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NFYB
    OriGene Protein Over-expression Lysate for NFYB
    OriGene MassSpec for NFYB
    OriGene Custom Protein Services for NFYB
    GenScript Custom Purified and Recombinant Proteins Services for NFYB
    Novus Biologicals NFYB Protein
    Novus Biologicals NFYB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NFYB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NFYB
    OriGene Custom Antibody Services for NFYB
    Novus Biologicals NFYB Antibodies
    Abcam antibodies for NFYB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NFYB
    LSBio Antibodies in human, mouse, rat for NFYB

    NFYB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFYB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFYB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR009072 Histone-fold
     IPR003956 Transcrpt_fac_NFYB/HAP3_CS
     IPR003957 Transcrpt_fac_NFYB/HAP3
     IPR003958 CBFA_NFYB_domain

    Graphical View of Domain Structure for InterPro Entry P25208

    ProtoNet protein and cluster: P25208

    2 Blocks protein domains:
    IPB003957 CCAAT-binding transcription factor subunit A signature
    IPB003958 Transcription factor CBF/NF-Y/archaeal histone


    UniProtKB/Swiss-Prot: NFYB_HUMAN, P25208
    Domain: Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be
    involved in subunit interaction and DNA binding, and the Glu-rich C domain
    Similarity: Belongs to the NFYB/HAP3 subunit family


    NFYB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFYB_HUMAN, P25208
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
    for example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYB:
    nuclear transcription factor NF-Y,B subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a
    variety of promoters,similarity with H2B

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI12401788
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    NFYB for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NFYB:
     Decreased viability with pacli  Increased S DNA content  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFYB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFYB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFYB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFYB

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NFYB (see all 484):
    AASS,  ABI3,  ACADSB,  ACSL3,  ADNP2,  ADORA2B,  ADRA2B,  AGBL5,  AGPAT5,  AKAP9

    miRNA
    Products:
        
    miRTarBase miRNAs that target NFYB:
    hsa-mir-181a-5p (MIRT025209), hsa-mir-30c-5p (MIRT047937), hsa-mir-485-3p (MIRT005607)

    Block miRNA regulation of human, mouse, rat NFYB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFYB (see all 105):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-631 hsa-miR-300 hsa-miR-200a hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidNFYB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFYB
    Predesigned siRNA for gene silencing in human, mouse, rat NFYB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFYB

    Clone
    Products:
         
    OriGene clones in human, mouse for NFYB (see all 6)
    OriGene ORF clones in mouse, rat for NFYB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFYB (NM_006166)
    Sino Biological Human cDNA Clone for NFYB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFYB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFYB
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFYB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NFYB_HUMAN, P25208: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    chloroplast1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA15243141
    GO:0005654nucleoplasm TAS--
    GO:0016602CCAAT-binding factor complex IDA15243141

    NFYB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NFYB About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by ATF6-alpha0.00
    Activation of Chaperones by ATF6-alpha0.00
    3PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    4Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    Activation of Gene Expression by SREBP (SREBF)0.75
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NFYB
        TGF-beta Receptor Signaling Pathway
    Direct p53 effectors
    Validated targets of C-MYC transcriptional repression


    4 Reactome Pathways for NFYB
        PPARA activates gene expression
    ATF6-alpha activates chaperone genes
    Activation of gene expression by SREBF (SREBP)
    ATF4 activates genes


    3 Kegg Pathways  (Kegg details for NFYB):
        Antigen processing and presentation
    Tuberculosis
    HTLV-I infection


    NFYB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NFYB: 
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFYB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFYB (P252081, 2, 3 ENSP000002400554) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA15243141
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0045893positive regulation of transcription, DNA-templated IEA--

    NFYB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFYB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NFYB gene: 
    NM_006166.3  

    Unigene Cluster for NFYB:

    Nuclear transcription factor Y, beta
    Hs.84928  [show with all ESTs]
    Unigene Representative Sequence: NM_006166
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240055(uc001tkl.1) ENST00000551727 ENST00000550189 ENST00000551446
    ENST00000550881(uc009zum.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFYB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFYB (see all 105):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-631 hsa-miR-300 hsa-miR-200a hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidNFYB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFYB
    Predesigned siRNA for gene silencing in human, mouse, rat NFYB
    Clone
    Products:
         
    OriGene clones in human, mouse for NFYB (see all 6)
    OriGene ORF clones in mouse, rat for NFYB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFYB (NM_006166)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFYB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFYB
    OriGene qSTAR qPCR primer pairs in human, mouse for NFYB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFYB
      QuantiTect SYBR Green Assays in human, mouse, rat NFYB
      QuantiFast Probe-based Assays in human, mouse, rat NFYB

    Additional mRNA sequence: 

    AK291934.1 AK311706.1 BC005316.1 BC005317.1 BC007035.1 L06145.1 X59710.1 

    14 DOTS entries:

    DT.95300163  DT.314555  DT.92433377  DT.121183631  DT.95300158  DT.92039080  DT.100025873  DT.100814246 
    DT.100814247  DT.121183616  DT.121183637  DT.92433378  DT.423963  DT.97817897 

    Selected AceView cDNA sequences (see all 188):

    BC005316 AA307919 BP343094 BQ027539 AA385919 BU737309 BM967001 AA573456 
    CD677713 CF136748 BU429322 AI057629 AV706348 AI804118 BQ008158 BI767198 
    AL044818 CB156993 N90429 CN482755 AW611543 AA994736 BC005317 NM_006166 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFYB (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:              -     -     -     -           -     -     -                                                               
    SP2:                          -     -           -     -     -                                                               
    SP3:                                -           -     -     -                                                               
    SP4:                                            -     -     -                                                               
    SP5:                                                  -     -                                                               


    ECgene alternative splicing isoforms for NFYB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NFYB expression in normal human tissues (normalized intensities)      NFYB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NFYB Expression
    About this image


    NFYB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    NFYB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFYB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.84928
        Pathway & Disease-focused RT2 Profiler PCR Array including NFYB: 
              Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFYB
    OriGene qSTAR qPCR primer pairs in human, mouse for NFYB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFYB
    QuantiTect SYBR Green Assays in human, mouse, rat NFYB
    QuantiFast Probe-based Assays in human, mouse, rat NFYB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYB gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfyb1 , 5 nuclear transcription factor-Y beta1, 5 88.73(n)1
    99.03(a)1
      10 (40.25 cM)5
    180451  NM_010914.21  NP_035044.11 
     827487015 
    chicken
    (Gallus gallus)
    Aves NFYB1 nuclear transcription factor Y, beta 86.53(n)
    98.68(a)
      396205  NM_205269.1  NP_990600.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFYB6
    nuclear transcription factor Y, beta
    97(a)
    1 ↔ 1
    5(18257248-18273485)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4192 X.laevis mRNA for CAAT-box DNA binding protein subunit more 80.19(n)    AF041204.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147642 Transcribed sequence with moderate similarity to protein more 75.69(n)    BI533139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nf-YB1 Nuclear factor Y-box B 58.33(n)
    64(a)
      35261  NM_136153.3  NP_609997.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nfyb-16
    Protein NFYB-1 (nfyb-1) mRNA, complete cds
    18(a)
    1 ↔ 1
    II(461665-467365) WBGene00021132
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAP3(YBL021C)4
    HAP31
    Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p more4
    HAP31
    56.75(n)1
    57.02(a)1
      2(182094-181660)4
    8522601, 4  NP_009532.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NF-YB101 NF-YB10 64(n)
    66(a)
      824502  NM_115194.2  NP_190902.2 
    rice
    (Oryza sativa)
    Liliopsida Os.226372 Oryza sativa (japonica cultivar-group) OsHAP3A mRNA more 69.42(n)    NM_190472.1 


    ENSEMBL Gene Tree for NFYB (if available)
    TreeFam Gene Tree for NFYB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NFYB gene
    POLE32  
    3 SIMAP similar genes for NFYB using alignment to 2 protein entries:     NFYB_HUMAN (see all proteins):
    POLE3    DKFZp666G145    DR1

    NFYB for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NFYB
    PGOHUM00000237716 PGOHUM00000235460 PGOHUM00000249305


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NFYB (see all 385)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385938571,2
    --104510375(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs619391901,2
    C--104510455(+) CTACTG/ACTGTA 1 -- ds50013Minor allele frequency- A:0.08NA EA 242
    rs1434083501,2
    C--104510517(+) GTTAAC/G/TTGGTA 1 -- ds50010--------
    rs111119001,2
    C,F,A,H--104510676(+) GAAGGC/TAGCAT 1 -- ds500124Minor allele frequency- T:0.17NS EA NA WA 2686
    rs1908408111,2
    --104510782(+) GCTACC/TTAAGT 1 -- ds50010--------
    rs1830514601,2
    --104510816(+) CTCACA/GGAAAC 1 -- ds50010--------
    rs1854450061,2
    --104511248(+) AGTGGC/TGCGAT 1 -- ut310--------
    rs1906971881,2
    --104511330(+) CAGGTA/GTGCAC 1 -- ut310--------
    rs1471293081,2
    --104511372(+) AGAGAC/TGGGGG 1 -- ut310--------
    rs1828117931,2
    --104511442(+) TGGCCC/TCCCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NFYB (104510855 - 104532067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NFYB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23395CNV Loss19812545
    nsv819113CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFYB
    DNA2.0 Custom Variant and Variant Library Synthesis for NFYB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 189904    OMIM disorders: --

    16 diseases for NFYB:    About MalaCards
    osteochondritis dissecans    cleidocranial dysplasia    fragile x syndrome    lymphoblastic leukemia
    tuberculosis    neuroblastoma    acute myeloid leukemia    myeloid leukemia
    leukemia    prostate cancer    hiv-1    prostatitis
    retinitis    malaria    cerebritis    neuronitis


    NFYB for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: NFYB (2 documents)

    Export disorders for NFYB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NFYB gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with NFYB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PubMed id 9612081)1, 3, 9 Maity S.N. and de Crombrugghe B. (Trends Biochem. Sci. 1998)
    2. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PubMed id 23332751)1, 2 Nardini M.... Mantovani R. (Cell 2013)
    3. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. (PubMed id 15243141)1, 2 Chattopadhyay C.... Maity S.N. (Nucleic Acids Res. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. (PubMed id 12401788)1, 2 Romier C.... Moras D. (J. Biol. Chem. 2003)
    6. Evolutionary variation of the CCAAT-binding transcription factor NF- Y. (PubMed id 1549471)1, 2 Li X.-Y.... Mathis D. (Nucleic Acids Res. 1992)
    7. Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain. (PubMed id 1577736)1, 2 Li X.-Y....Mathis D. (J. Biol. Chem. 1992)
    8. One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes. (PubMed id 1774067)1, 3 Li X.Y....Mathis D. (Genomics 1991)
    9. CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues. (PubMed id 9153318)1, 9 Bellorini M....Mantovani R. (Nucleic Acids Res. 1997)
    10. Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y. (PubMed id 9032250)1, 9 Pise-Masison C.A....Brady J.N. (Mol. Cell. Biol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4801 HGNC: 7805 AceView: NFYB Ensembl:ENSG00000120837 euGenes: HUgn4801
    ECgene: NFYB Kegg: 4801 H-InvDB: NFYB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NFYB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFYB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NFYB gene:
    Search GeneIP for patents involving NFYB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NFYB   OriGene RNAi products in human, mouse, rat for NFYB  
     OriGene qPCR primer pairs and template standards for NFYB   OriGene Protein Over-expression Lysate for NFYB  
     OriGene MassSpec something-or-other for NFYB   OriGene clones in human, mouse for NFYB  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFYB   OriGene Purified Protein for NFYB  
     OriGene ORF clones in mouse, rat for NFYB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFYB   OriGene Custom Protein Services for NFYB  

     
     
     Block miRNA regulation of human, mouse, rat NFYB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NFYB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFYB Predesigned siRNA for gene silencing in human, mouse, rat NFYB
     QuantiFast Probe-based Assays in human, mouse, rat NFYB QuantiTect SYBR Green Assays in human, mouse, rat NFYB
     PCR Arrays including human, mouse, rat NFYB Search Chromatin IP Primers for NFYB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFYB  GeneGlobe Interaction Network for NFYB
     Regulatory tfbs in NFYB promoter
     GenScript Custom Purified and Recombinant Proteins Services for NFYB GenScript cDNA clones with any tag delivered in your preferred vector for NFYB
     GenScript Custom Assay Services for NFYB GenScript Custom overexpressing Cell Line Services for NFYB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NFYB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NFYB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NFYB antibodies
     NFYB proteins
     NFYB lysates
     Antibodies for NFYB
     See all of Abcam's Antibodies, Kits and Proteins for NFYB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for NFYB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYB
     SwitchGear 3'UTR luciferase reporter plasmids for NFYB
     SwitchGear Promoter luciferase reporter plasmids for NFYB
     ThermoFisher Antibody for NFYB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFYB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFYB
     LSBio Antibodies in human, mouse, rat for NFYB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFYB gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4