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Aliases for NFYB Gene

Aliases for NFYB Gene

  • Nuclear Transcription Factor Y Subunit Beta 2 3 5
  • Nuclear Transcription Factor Y Subunit B 3 4
  • CAAT Box DNA-Binding Protein Subunit B 3 4
  • Nuclear Transcription Factor Y, Beta 2 3
  • NF-YB 3 4
  • HAP3 3 4
  • CCAAT-Binding Transcription Factor Subunit A 3
  • Transcription Factor NF-Y, B Subunit 3
  • CBF-A 3
  • CBF-B 3

External Ids for NFYB Gene

Previous GeneCards Identifiers for NFYB Gene

  • GC12M103626
  • GC12M104393
  • GC12M103015
  • GC12M103013
  • GC12M104510
  • GC12M101570

Summaries for NFYB Gene

Entrez Gene Summary for NFYB Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYB Gene

NFYB (Nuclear Transcription Factor Y Subunit Beta) is a Protein Coding gene. Among its related pathways are Allograft rejection and Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is POLE3.

UniProtKB/Swiss-Prot for NFYB Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYB Gene

Additional gene information for NFYB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYB Gene

Genomics for NFYB Gene

Regulatory Elements for NFYB Gene

Enhancers for NFYB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H104063 1.1 ENCODE 15.8 +73.7 73681 2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 NFYB C12orf73 GC12M104050 HCFC2
GH12H103964 1.2 ENCODE 11.8 +172.3 172338 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 TDG C12orf73 NFYB HSP90B1 TTC41P GC12P104022
GH12H104985 1 ENCODE 11.7 -848.5 -848473 2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 GTF3C2 SLC30A9 GLIS2 SLC41A2 NFYB C12orf45 ALDH1L2 RPL18AP3 PIR60982 LOC105369952
GH12H104055 0.9 Ensembl ENCODE 11.2 +81.7 81690 1 FOXA2 HLF MAX RAD21 YY1 JUND HNF4A RCOR1 ZBTB33 NFYB TDG NT5DC3 GLT8D2 GC12P104032 GC12P104033 GC12P104034 GC12P104035 PIR60229
GH12H104136 1 ENCODE 6.2 +0.5 530 3 PKNOX1 SIN3A DMAP1 YY1 ZNF766 GLIS2 ZNF143 FOS RUNX3 SP3 TDG WASHC4 NFYB RNA5SP370
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFYB on UCSC Golden Path with GeneCards custom track

Promoters for NFYB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056499 589 1801 PKNOX1 SIN3A DMAP1 YY1 ZNF766 GLIS2 ZNF143 FOS RUNX3 SP3

Genomic Location for NFYB Gene

Chromosome:
12
Start:
104,117,077 bp from pter
End:
104,138,289 bp from pter
Size:
21,213 bases
Orientation:
Minus strand

Genomic View for NFYB Gene

Genes around NFYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYB Gene

Proteins for NFYB Gene

  • Protein details for NFYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25208-NFYB_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit beta
    Protein Accession:
    P25208
    Secondary Accessions:
    • A8K7B9
    • Q96IY8

    Protein attributes for NFYB Gene

    Size:
    207 amino acids
    Molecular mass:
    22831 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.
    SequenceCaution:
    • Sequence=CAA42230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYB Gene

neXtProt entry for NFYB Gene

Post-translational modifications for NFYB Gene

  • Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at Lys-121.
  • Ubiquitination at posLast=140140
  • Modification sites at PhosphoSitePlus

Other Protein References for NFYB Gene

No data available for DME Specific Peptides for NFYB Gene

Domains & Families for NFYB Gene

Gene Families for NFYB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NFYB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25208

UniProtKB/Swiss-Prot:

NFYB_HUMAN :
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
  • Belongs to the NFYB/HAP3 subunit family.
Domain:
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Family:
  • Belongs to the NFYB/HAP3 subunit family.
genes like me logo Genes that share domains with NFYB: view

Function for NFYB Gene

Molecular function for NFYB Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,B subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,similarity with H2B
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Ontology (GO) - Molecular Function for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 11256944
GO:0003677 DNA binding IEA,IDA 15243141
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS,IEA --
GO:0005515 protein binding IPI 12401788
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with NFYB: view
genes like me logo Genes that share phenotypes with NFYB: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for NFYB Gene

Selected GeneGlobe predicted Target genes for NFYB

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFYB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYB Gene

Localization for NFYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYB gene
Compartment Confidence
nucleus 5
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15243141
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
GO:0090575 RNA polymerase II transcription factor complex IDA 11256944
genes like me logo Genes that share ontologies with NFYB: view

Pathways & Interactions for NFYB Gene

genes like me logo Genes that share pathways with NFYB: view

Gene Ontology (GO) - Biological Process for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 15243141
GO:0045540 regulation of cholesterol biosynthetic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with NFYB: view

No data available for SIGNOR curated interactions for NFYB Gene

Drugs & Compounds for NFYB Gene

No Compound Related Data Available

Transcripts for NFYB Gene

Unigene Clusters for NFYB Gene

Nuclear transcription factor Y, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFYB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NFYB Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - - -

Relevant External Links for NFYB Gene

GeneLoc Exon Structure for
NFYB
ECgene alternative splicing isoforms for
NFYB

Expression for NFYB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFYB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Retina (7.9), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFYB Gene



Protein tissue co-expression partners for NFYB Gene

NURSA nuclear receptor signaling pathways regulating expression of NFYB Gene:

NFYB

SOURCE GeneReport for Unigene cluster for NFYB Gene:

Hs.84928

Evidence on tissue expression from TISSUES for NFYB Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with NFYB: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFYB Gene

Orthologs for NFYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYB 33
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFYB 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYB 33 34
  • 94.69 (n)
dog
(Canis familiaris)
Mammalia NFYB 33 34
  • 94.04 (n)
mouse
(Mus musculus)
Mammalia Nfyb 33 16 34
  • 88.73 (n)
oppossum
(Monodelphis domestica)
Mammalia NFYB 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfyb 33
  • 87.12 (n)
chicken
(Gallus gallus)
Aves NFYB 33 34
  • 86.53 (n)
lizard
(Anolis carolinensis)
Reptilia NFYB 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfyb 33
  • 81.32 (n)
Str.5961 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.419 33
zebrafish
(Danio rerio)
Actinopterygii nfyba 33 34
  • 71.08 (n)
nfybb 34
  • 70 (a)
OneToMany
Dr.14764 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.388 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008344 33
  • 63 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nf-YB 33 34
  • 58.33 (n)
worm
(Caenorhabditis elegans)
Secernentea nfyb-1 34
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP3 33 34 36
  • 56.75 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR014C 33
  • 53.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10429g 33
  • 51.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NF-YB10 33
  • 64 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6634 33
rice
(Oryza sativa)
Liliopsida Os05g0573500 33
  • 59.52 (n)
Os.22637 33
barley
(Hordeum vulgare)
Liliopsida Hv.7207 33
wheat
(Triticum aestivum)
Liliopsida Ta.4075 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6795 34
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.811 33
Species where no ortholog for NFYB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYB Gene

ENSEMBL:
Gene Tree for NFYB (if available)
TreeFam:
Gene Tree for NFYB (if available)

Paralogs for NFYB Gene

Paralogs for NFYB Gene

(3) SIMAP similar genes for NFYB Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NFYB Gene

genes like me logo Genes that share paralogs with NFYB: view

Variants for NFYB Gene

Sequence variations from dbSNP and Humsavar for NFYB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000084724 -- 104,121,885(+) ACTAA(A/C)GATAT intron-variant
rs1000114938 -- 104,131,252(+) AAAGC(C/T)GCTAA intron-variant
rs1000193172 -- 104,117,348(+) GTTAG(C/T)ACTAC downstream-variant-500B, utr-variant-3-prime
rs1000222079 -- 104,129,166(+) TCCCT(A/G)GAATG intron-variant
rs1000225745 -- 104,117,683(+) AATTA(C/T)AGGCA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NFYB Gene

Variant ID Type Subtype PubMed ID
dgv2841n54 CNV gain 21841781
esv23395 CNV loss 19812545
esv3580446 CNV loss 25503493
nsv1126319 CNV deletion 24896259
nsv560047 CNV gain 21841781
nsv560048 CNV gain 21841781
nsv819113 CNV gain 19587683
nsv952468 CNV deletion 24416366

Variation tolerance for NFYB Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYB Gene

Disorders for NFYB Gene

Relevant External Links for NFYB

Human Genome Epidemiology (HuGE) Navigator
NFYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYB

No disorders were found for NFYB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYB Gene

Publications for NFYB Gene

  1. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PMID: 9612081) Maity SN … de Crombrugghe B (Trends in biochemical sciences 1998) 2 3 22 60
  2. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M … Mantovani R (Cell 2013) 3 4 60
  3. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. (PMID: 15964792) Kahle J … Albig W (Molecular and cellular biology 2005) 3 22 60
  4. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. (PMID: 15243141) Chattopadhyay C … Maity SN (Nucleic acids research 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for NFYB Gene

Sources for NFYB Gene

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