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Aliases for NFYB Gene

Aliases for NFYB Gene

  • Nuclear Transcription Factor Y Subunit Beta 2 3 5
  • Nuclear Transcription Factor Y Subunit B 3 4
  • CAAT Box DNA-Binding Protein Subunit B 3 4
  • Nuclear Transcription Factor Y, Beta 2 3
  • NF-YB 3 4
  • HAP3 3 4
  • CCAAT-Binding Transcription Factor Subunit A 3
  • Transcription Factor NF-Y, B Subunit 3
  • CBF-A 3
  • CBF-B 3

External Ids for NFYB Gene

Previous GeneCards Identifiers for NFYB Gene

  • GC12M103626
  • GC12M104393
  • GC12M103015
  • GC12M103013
  • GC12M104510
  • GC12M101570

Summaries for NFYB Gene

Entrez Gene Summary for NFYB Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYB Gene

NFYB (Nuclear Transcription Factor Y Subunit Beta) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is POLE3.

UniProtKB/Swiss-Prot for NFYB Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYB Gene

Genomics for NFYB Gene

Regulatory Elements for NFYB Gene

Enhancers for NFYB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F104063 1.1 ENCODE 15.8 +73.7 73681 2.8 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 NFYB C12orf73 GC12M104050 HCFC2
GH12F103570 1.4 Ensembl ENCODE 11.7 +566.8 566816 1.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 STAB2 NFYB ENSG00000212594 C12orf42 GLT8D2 GC12P103574 LOC101929084
GH12F103964 1.2 ENCODE 11.8 +172.3 172338 3.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 C12orf73 NFYB TTC41P HSP90B1 MIR3652 GLT8D2 TDG GC12P104022
GH12F104985 1 ENCODE 11.7 -848.5 -848473 2.3 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GTF3C2 SLC41A2 NFYB C12orf45 ALDH1L2 RPL18AP3 LOC105369952 PIR60982
GH12F104093 0.8 ENCODE 11.6 +43.9 43921 1.1 YBX3 HDGF PKNOX1 NFRKB TSC22D4 CDC5L YBX1 PLRG1 ZKSCAN1 CTBP1 NFYB GC12M104073 RNA5SP370
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFYB on UCSC Golden Path with GeneCards custom track

Promoters for NFYB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000436060 589 2601 PKNOX1 DMAP1 ZNF48 YY1 GLIS2 FOS SP3 GTF2B NFYC REST

Genomic Location for NFYB Gene

Chromosome:
12
Start:
104,117,077 bp from pter
End:
104,138,289 bp from pter
Size:
21,213 bases
Orientation:
Minus strand

Genomic View for NFYB Gene

Genes around NFYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYB Gene

Proteins for NFYB Gene

  • Protein details for NFYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25208-NFYB_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit beta
    Protein Accession:
    P25208
    Secondary Accessions:
    • A8K7B9
    • Q96IY8

    Protein attributes for NFYB Gene

    Size:
    207 amino acids
    Molecular mass:
    22831 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.
    SequenceCaution:
    • Sequence=CAA42230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYB Gene

neXtProt entry for NFYB Gene

Post-translational modifications for NFYB Gene

  • Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at Lys-121.
  • Ubiquitination at Lys 140
  • Modification sites at PhosphoSitePlus

Other Protein References for NFYB Gene

No data available for DME Specific Peptides for NFYB Gene

Domains & Families for NFYB Gene

Suggested Antigen Peptide Sequences for NFYB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25208

UniProtKB/Swiss-Prot:

NFYB_HUMAN :
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
  • Belongs to the NFYB/HAP3 subunit family.
Domain:
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Family:
  • Belongs to the NFYB/HAP3 subunit family.
genes like me logo Genes that share domains with NFYB: view

No data available for Gene Families for NFYB Gene

Function for NFYB Gene

Molecular function for NFYB Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,B subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,similarity with H2B
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Ontology (GO) - Molecular Function for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15243141
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS --
GO:0005515 protein binding IPI 12401788
GO:0032403 protein complex binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NFYB: view
genes like me logo Genes that share phenotypes with NFYB: view

Animal Model Products

Transcription Factor Targets for NFYB Gene

Selected GeneGlobe predicted Target genes for NFYB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYB Gene

Localization for NFYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYB gene
Compartment Confidence
nucleus 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15243141
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
genes like me logo Genes that share ontologies with NFYB: view

Pathways & Interactions for NFYB Gene

genes like me logo Genes that share pathways with NFYB: view

Gene Ontology (GO) - Biological Process for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 15243141
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NFYB: view

No data available for SIGNOR curated interactions for NFYB Gene

Transcripts for NFYB Gene

Unigene Clusters for NFYB Gene

Nuclear transcription factor Y, beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFYB Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - - -

Relevant External Links for NFYB Gene

GeneLoc Exon Structure for
NFYB
ECgene alternative splicing isoforms for
NFYB

Expression for NFYB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFYB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Retina (7.9), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFYB Gene



Protein tissue co-expression partners for NFYB Gene

NURSA nuclear receptor signaling pathways regulating expression of NFYB Gene:

NFYB

SOURCE GeneReport for Unigene cluster for NFYB Gene:

Hs.84928
genes like me logo Genes that share expression patterns with NFYB: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFYB Gene

Orthologs for NFYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYB 34
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFYB 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYB 34 35
  • 94.69 (n)
dog
(Canis familiaris)
Mammalia NFYB 34 35
  • 94.04 (n)
mouse
(Mus musculus)
Mammalia Nfyb 34 16 35
  • 88.73 (n)
oppossum
(Monodelphis domestica)
Mammalia NFYB 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfyb 34
  • 87.12 (n)
chicken
(Gallus gallus)
Aves NFYB 34 35
  • 86.53 (n)
lizard
(Anolis carolinensis)
Reptilia NFYB 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfyb 34
  • 81.32 (n)
Str.5961 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.419 34
zebrafish
(Danio rerio)
Actinopterygii nfyba 34 35
  • 71.08 (n)
nfybb 35
  • 70 (a)
OneToMany
Dr.14764 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.388 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008344 34
  • 63 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nf-YB 34 35
  • 58.33 (n)
worm
(Caenorhabditis elegans)
Secernentea nfyb-1 35
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP3 34 35 37
  • 56.75 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR014C 34
  • 53.56 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10429g 34
  • 51.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NF-YB10 34
  • 64 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6634 34
rice
(Oryza sativa)
Liliopsida Os05g0573500 34
  • 59.52 (n)
Os.22637 34
barley
(Hordeum vulgare)
Liliopsida Hv.7207 34
wheat
(Triticum aestivum)
Liliopsida Ta.4075 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6795 35
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.811 34
Species where no ortholog for NFYB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYB Gene

ENSEMBL:
Gene Tree for NFYB (if available)
TreeFam:
Gene Tree for NFYB (if available)

Paralogs for NFYB Gene

Paralogs for NFYB Gene

(3) SIMAP similar genes for NFYB Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NFYB Gene

genes like me logo Genes that share paralogs with NFYB: view

Variants for NFYB Gene

Sequence variations from dbSNP and Humsavar for NFYB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10507174 -- 104,128,302(+) GAACC(A/G)TAACA intron-variant
rs10507175 -- 104,128,342(+) AAGTA(A/G)CCTAG intron-variant
rs10861160 -- 104,124,613(+) CCCAA(C/T)ATAGC intron-variant
rs11111900 -- 104,116,898(+) GAAGG(C/T)AGCAT downstream-variant-500B
rs111446046 -- 104,128,728(+) GTGGC(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFYB Gene

Variant ID Type Subtype PubMed ID
nsv952468 CNV deletion 24416366
nsv819113 CNV gain 19587683
nsv560048 CNV gain 21841781
nsv560047 CNV gain 21841781
nsv1126319 CNV deletion 24896259
esv3580446 CNV loss 25503493
esv23395 CNV loss 19812545
dgv2841n54 CNV gain 21841781

Variation tolerance for NFYB Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYB Gene

Disorders for NFYB Gene

Relevant External Links for NFYB

Human Genome Epidemiology (HuGE) Navigator
NFYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYB

No disorders were found for NFYB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYB Gene

Publications for NFYB Gene

  1. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PMID: 9612081) Maity S.N. … de Crombrugghe B. (Trends Biochem. Sci. 1998) 2 3 22 64
  2. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M. … Mantovani R. (Cell 2013) 3 4 64
  3. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. (PMID: 15964792) Kahle J. … Albig W. (Mol. Cell. Biol. 2005) 3 22 64
  4. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. (PMID: 15243141) Chattopadhyay C. … Maity S.N. (Nucleic Acids Res. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NFYB Gene

Sources for NFYB Gene

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