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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFYB Gene

protein-coding   GIFtS: 60
GCID: GC12M104510

nuclear transcription factor Y, beta

 Explore 11 diseases affiliated with
NFYB via our new
 Human Malady Compendium 
Biological research products
for NFYB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nuclear Transcription Factor Y, Beta1 2     CAAT Box DNA-Binding Protein Subunit B2 3
HAP31 2 3     CBF-B2
NF-YB1 2 3     CCAAT-Binding Transcription Factor Subunit A2
CBF-A1 2     Nuclear Transcription Factor Y Subunit Beta2
Nuclear Transcription Factor Y Subunit B2 3     Transcription Factor NF-Y, B Subunit2

External Ids:    HGNC: 78051   Entrez Gene: 48012   Ensembl: ENSG000001208377   OMIM: 1899045   UniProtKB: P252083   

Export aliases for NFYB gene to outside databases

Previous GC identifers: GC12M103626 GC12M104393 GC12M103015 GC12M103013 GC12M101570


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFYB:
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor
that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product,
subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer
binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of
the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and
experiments with mutants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NFYB_HUMAN, P25208
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for
example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYB


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFYB gene promoter:
         HOXA9B   HOXA9   HNF-1   HNF-4alpha2   AP-2gamma   Meis-1b   Meis-1   HNF-1A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFYB promoter sequence
   Search SABiosciences Chromatin IP Primers for NFYB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFYB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22-q23   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q22-q23

NFYB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYB gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M104510:  view genomic region     (about GC identifiers)

Start:
104,510,855 bp from pter      End:
104,532,067 bp from pter
Size:
21,213 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NFYB_HUMAN, P25208 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit beta  
Size: 207 amino acids; 22831 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must
interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP
Subcellular location: Nucleus
Sequence caution: Sequence=CAA42230.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for NFYB:
1N1J (3D)        4AWL (3D)    
Secondary accessions: A8K7B9 Q96IY8

Explore the universe of human proteins at neXtProt for NFYB: NX_P25208

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25208

  • NFYB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006157.1  
    ENSEMBL proteins: 
     ENSP00000240055   ENSP00000447486   ENSP00000448250  
    Reactome Protein details: P25208
    Human Recombinant Protein Products: 
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    Novus Biologicals NFYB Protein
    Novus Biologicals NFYB Lysate
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15964792
    GO:0016602CCAAT-binding factor complex IDA15243141


    NFYB for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NFYB for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003957 Transcrpt_fac_CBFA/NFYB_topo
     IPR003958 CBFA_NFYB_domain
     IPR009072 Histone-fold
     IPR003956 Transcrpt_fac_NFYB/HAP3_CS

    Graphical View of Domain Structure for InterPro Entry P25208

    ProtoNet protein and cluster: P25208

    2 Blocks protein families:
    IPB003957 CCAAT-binding transcription factor subunit A signature
    IPB003958 Transcription factor CBF/NF-Y/archaeal histone


    UniProtKB/Swiss-Prot: NFYB_HUMAN, P25208
    Domain: Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be
    involved in subunit interaction and DNA binding, and the Glu-rich C domain
    Similarity: Belongs to the NFYB/HAP3 subunit family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NFYB_HUMAN, P25208
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for
    example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYB:
    nuclear transcription factor NF-Y,B subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a
    variety of promoters,similarity with H2B

    10/504 SABiosciences Target genes for NFYB (see all 504):
    AASS ABI3 ACADSB ACSL3 ADNP2 ADORA2B ADRA2B AGBL5 AGPAT5 AKAP9

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFYB
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate NFYB (see all 105):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-631 hsa-miR-300 hsa-miR-200a hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidNFYB 3' UTR sequence
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    NFYB for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for NFYB:
     Decreased viability with pacli  Increased S DNA content  Synthetic lethal with c-Myc af 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of Mevalonate Kinase (MVK)
    Expression of Mevalonate Kinase (MVK)1.00
    Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)0.75
    Expression of 7-Dehydrocholesterol Reductase (DHCR7)0.75
    Expression of Phosphomevalonate Kinase (PMVK)0.75
    Expression of Lanosterol Demethylase (CYP51A1)0.75
    Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)0.75
    Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)0.75
    Expression of Fatty Acid Synthase (FASN)0.62
    2Expression of Lathosterol Oxidase (SC5D, SC5DL)
    Expression of Lathosterol Oxidase (SC5D, SC5DL)1.00
    Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)0.71
    Expression of Farnesyl Diphosphate Synthase (FDPS)0.71
    Expression of Squalene Monooxygenase (SQLE)0.71
    Expression of TM7SF20.71
    Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)0.57
    Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)0.71
    3Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    4Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)1.00
    Activation of Gene Expression by SREBP (SREBF)0.67
    5Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for NFYB 
        TGF-beta Receptor Signaling Pathway
    Direct p53 effectors
    Validated targets of C-MYC transcriptional repression

    5/22        Reactome Pathways for NFYB (see all 22)
        Expression of Fatty Acid Synthase (FASN)
    Expression of Mevalonate Kinase (MVK)
    Expression of Squalene Monooxygenase (SQLE)
    Metabolism
    Expression of 7-Dehydrocholesterol Reductase (DHCR7)


    2         Kegg Pathways  (Kegg details for NFYB):
        Antigen processing and presentation
    Tuberculosis


    NFYB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFYB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for NFYB (P252081, 2, 3 ENSP000002400554) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFYCQ139521, 2, 3, ENSP000003966204EBI-389728,EBI-389755 MINT-25006 I2D: score=7 STRING: ENSP00000396620
    HDAC4P565242, 3MINT-49705 I2D: score=1 
    NFYAP235111, 3, ENSP000003457024EBI-389728,EBI-389739 I2D: score=4 STRING: ENSP00000345702
    DRAP1Q149192, 3, ENSP000003078504MINT-66211 I2D: score=5 STRING: ENSP00000307850
    MYCP011063, ENSP000003672074I2D: score=4 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA15243141
    GO:0045893positive regulation of transcription, DNA-dependent IEA--


    NFYB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFYB
    Search CenterWatch for drugs/clinical trials and news about NFYB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFYB gene: 
    NM_006166.3  

    Unigene Cluster for NFYB:

    Nuclear transcription factor Y, beta
    Hs.84928  [show with all ESTs]
    Unigene Representative Sequence: NM_006166
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240055(uc001tkl.1) ENST00000551727 ENST00000550189 ENST00000551446
    ENST00000550881(uc009zum.1)

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    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate NFYB (see all 105):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-631 hsa-miR-300 hsa-miR-200a hsa-miR-485-3p hsa-miR-30d hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidNFYB 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK291934.1 AK311706.1 BC005316.1 BC005317.1 BC007035.1 L06145.1 X59710.1 

    14 DOTS entries:

    DT.95300163  DT.314555  DT.92433377  DT.92039080  DT.121183631  DT.95300158  DT.100025873  DT.100814246 
    DT.100814247  DT.121183616  DT.121183637  DT.92433378  DT.97817897  DT.423963 

    24/188 AceView cDNA sequences (see all 188):

    AA994736 BF590535 BQ008158 CD677713 AW664434 BC005316 CF136748 N50876 
    BQ027539 BQ014601 NM_006166 BU429322 CR616440 AI804118 AA194974 AA385919 
    BM967037 CN482755 AA573456 AI057629 N90429 AL044818 BG390953 BX119230 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NFYB (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:              -     -     -     -           -     -     -                                                               
    SP2:                          -     -           -     -     -                                                               
    SP3:                                -           -     -     -                                                               
    SP4:                                            -     -     -                                                               
    SP5:                                                  -     -                                                               


    ECgene alternative splicing isoforms for NFYB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFYB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NFYB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFYB

    SOURCE GeneReport for Unigene cluster: Hs.84928
        SABiosciences Expression via Pathway-Focused PCR Array including NFYB: 
              Transcription Factors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYB gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfyb1 , 5 nuclear transcription factor-Y beta1, 5 88.73(n)1
    99.03(a)1
      10 (40.25 cM)5
    180451  NM_010914.21  NP_035044.11 
     827487015 
    chicken
    (Gallus gallus)
    Aves NFYB1 nuclear transcription factor Y, beta 86.53(n)
    98.68(a)
      396205  NM_205269.1  NP_990600.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFYB6
    --
    96(a)
    1 ↔ 1
    5(18258880-18267115)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4192 X.laevis mRNA for CAAT-box DNA binding protein subunit more 80.19(n)    AF041204.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147642 Transcribed sequence with moderate similarity to protein more 75.69(n)    BI533139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nf-YB1 Nuclear factor Y-box B 55.37(n)
    55.93(a)
      35261  NM_136153.3  NP_609997.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nfyb-16
    Nuclear transcription Factor Y, B (beta) subunit f...
    16(a)
    1 ↔ 1
    II(461665-467365)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAP3(YBL021C)4
    HAP31
    Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p more4
    Hap3p1
    56.61(n)1
    57.76(a)1
      2(182094-181660)4
    8522601, 4  NP_009532.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NF-YB31 nuclear transcription factor Y subunit B-3 64.9(n)
    67.26(a)
      827101  NM_117534.2  NP_193190.1 
    rice
    (Oryza sativa)
    Liliopsida Os.226372 Oryza sativa (japonica cultivar-group) OsHAP3A mRNA more 69.42(n)    NM_190472.1 


    ENSEMBL Gene Tree for NFYB (if available)
    TreeFam Gene Tree for NFYB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFYB gene
    POLE32  
    3 SIMAP similar genes for NFYB using alignment to 2 protein entries:     NFYB_HUMAN (see all proteins):
    POLE3    DKFZp666G145    DR1

    NFYB for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NFYB
    PGOHUM00000237716 PGOHUM00000235460 PGOHUM00000249305


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 NCBI SNPs in NFYB are shown (see all 293    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385938571,2
    --104510375(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs619391901,2
    C,--104510455(+) CTACTG/ACTGTA 1 -- ds50013Minor allele frequency- A:0.08NA EA 242
    rs1434083501,2
    --104510517(+) GTTAAG/TTGGTA 1 -- ds50010--------
    rs111119001,2
    C,F,A,H,--104510676(+) GAAGGC/TAGCAT 1 -- ds500124Minor allele frequency- T:0.17NS EA NA WA 2686
    rs1908408111,2
    --104510782(+) GCTACC/TTAAGT 1 -- ds50010--------
    rs1830514601,2
    --104510816(+) CTCACA/GGAAAC 1 -- ds50010--------
    rs1854450061,2
    --104511248(+) AGTGGC/TGCGAT 1 -- ut310--------
    rs1906971881,2
    --104511330(+) CAGGTA/GTGCAC 1 -- ut310--------
    rs1471293081,2
    --104511372(+) AGAGAC/TGGGGG 1 -- ut310--------
    rs1828117931,2
    --104511442(+) TGGCCC/TCCCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NFYB (104510855 - 104532067 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NFYB
         2 Indels: 71553 58549

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NFYB for disorders           About GeneDecksing

    OMIM gene information: 189904    OMIM disorders: --

    11 diseases for NFYB:    About MalaCards
    osteochondritis dissecans    fragile x syndrome    cleidocranial dysplasia    acute lymphoblastic leukemia
    lymphoblastic leukemia    leukemia    prostate cancer    neuroblastoma
    prostatitis    tuberculosis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NFYB (2 documents)

    Export disorders for NFYB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFYB gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with NFYB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PubMed id 9612081)1, 3, 9 Maity S.N. and de Crombrugghe B. (1998)
    2. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. (PubMed id 15243141)1, 2 Chattopadhyay C....Maity S.N. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. (PubMed id 12401788)1, 2 Romier C.... Moras D. (2003)
    5. Evolutionary variation of the CCAAT-binding transcription factor NF- Y. (PubMed id 1549471)1, 2 Li X.-Y.... Mathis D. (1992)
    6. Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain. (PubMed id 1577736)1, 2 Li X.-Y....Mathis D. (1992)
    7. One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes. (PubMed id 1774067)1, 3 Li X.Y....Mathis D. (1991)
    8. CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues. (PubMed id 9153318)1, 9 Bellorini M....Mantovani R. (1997)
    9. Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y. (PubMed id 9032250)1, 9 Pise-Masison C.A....Brady J.N. (1997)
    10. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. (PubMed id 15454570)1, 9 Uramoto H....Funa K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4801 HGNC: 7805 AceView: NFYB Ensembl:ENSG00000120837 euGenes: HUgn4801
    ECgene: NFYB Kegg: 4801 H-InvDB: NFYB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFYB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFYB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFYB gene:
    Search GeneIP for patents involving NFYB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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