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Aliases for NFYB Gene

Aliases for NFYB Gene

  • Nuclear Transcription Factor Y Subunit Beta 2 3 5
  • Nuclear Transcription Factor Y Subunit B 3 4
  • CAAT Box DNA-Binding Protein Subunit B 3 4
  • Nuclear Transcription Factor Y, Beta 2 3
  • NF-YB 3 4
  • HAP3 3 4
  • CCAAT-Binding Transcription Factor Subunit A 3
  • Transcription Factor NF-Y, B Subunit 3
  • CBF-A 3
  • CBF-B 3

External Ids for NFYB Gene

Previous GeneCards Identifiers for NFYB Gene

  • GC12M103626
  • GC12M104393
  • GC12M103015
  • GC12M103013
  • GC12M104510
  • GC12M101570

Summaries for NFYB Gene

Entrez Gene Summary for NFYB Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYB Gene

NFYB (Nuclear Transcription Factor Y Subunit Beta) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is POLE3.

UniProtKB/Swiss-Prot for NFYB Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Wiki entry for NFYB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYB Gene

Genomics for NFYB Gene

Regulatory Elements for NFYB Gene

Promoters for NFYB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NFYB on UCSC Golden Path with GeneCards custom track

Genomic Location for NFYB Gene

Chromosome:
12
Start:
104,117,077 bp from pter
End:
104,138,289 bp from pter
Size:
21,213 bases
Orientation:
Minus strand

Genomic View for NFYB Gene

Genes around NFYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYB Gene

Proteins for NFYB Gene

  • Protein details for NFYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25208-NFYB_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit beta
    Protein Accession:
    P25208
    Secondary Accessions:
    • A8K7B9
    • Q96IY8

    Protein attributes for NFYB Gene

    Size:
    207 amino acids
    Molecular mass:
    22831 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.
    SequenceCaution:
    • Sequence=CAA42230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFYB Gene

neXtProt entry for NFYB Gene

Proteomics data for NFYB Gene at MOPED

Post-translational modifications for NFYB Gene

  • Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at Lys-121.
  • Ubiquitination at Lys 140
  • Modification sites at PhosphoSitePlus

Other Protein References for NFYB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NFYB Gene

Domains & Families for NFYB Gene

Suggested Antigen Peptide Sequences for NFYB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25208

UniProtKB/Swiss-Prot:

NFYB_HUMAN :
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
  • Belongs to the NFYB/HAP3 subunit family.
Domain:
  • Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
Family:
  • Belongs to the NFYB/HAP3 subunit family.
genes like me logo Genes that share domains with NFYB: view

No data available for Gene Families for NFYB Gene

Function for NFYB Gene

Molecular function for NFYB Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,B subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,similarity with H2B
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

Gene Ontology (GO) - Molecular Function for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12401788
GO:0032403 protein complex binding IEA --
GO:0046982 protein heterodimerization activity IEA --
GO:0070491 repressing transcription factor binding IPI 19223331
genes like me logo Genes that share ontologies with NFYB: view
genes like me logo Genes that share phenotypes with NFYB: view

Animal Model Products

Transcription Factor Targets for NFYB Gene

Selected GeneGlobe predicted Target genes for NFYB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for NFYB Gene

Localization for NFYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFYB Gene COMPARTMENTS Subcellular localization image for NFYB gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for NFYB Gene

Pathways & Interactions for NFYB Gene

genes like me logo Genes that share pathways with NFYB: view

Gene Ontology (GO) - Biological Process for NFYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NFYB: view

No data available for SIGNOR curated interactions for NFYB Gene

Drugs & Compounds for NFYB Gene

No Compound Related Data Available

Transcripts for NFYB Gene

Unigene Clusters for NFYB Gene

Nuclear transcription factor Y, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFYB Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8: - - - -

Relevant External Links for NFYB Gene

GeneLoc Exon Structure for
NFYB
ECgene alternative splicing isoforms for
NFYB

Expression for NFYB Gene

mRNA expression in normal human tissues for NFYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFYB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Retina (7.9), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFYB Gene



SOURCE GeneReport for Unigene cluster for NFYB Gene Hs.84928

genes like me logo Genes that share expression patterns with NFYB: view

Protein tissue co-expression partners for NFYB Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFYB Gene

Orthologs for NFYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFYB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFYB 35
  • 94.69 (n)
  • 99.03 (a)
NFYB 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFYB 35
  • 94.04 (n)
  • 98.55 (a)
NFYB 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfyb 35
  • 88.73 (n)
  • 99.03 (a)
Nfyb 16
Nfyb 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFYB 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Nfyb 35
  • 87.12 (n)
  • 99.03 (a)
oppossum
(Monodelphis domestica)
Mammalia NFYB 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFYB 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFYB 35
  • 86.53 (n)
  • 98.68 (a)
NFYB 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFYB 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfyb 35
  • 81.32 (n)
  • 91.79 (a)
Str.5961 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.419 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14764 35
nfyba 35
  • 71.08 (n)
  • 82.35 (a)
nfyba 36
  • 81 (a)
OneToMany
nfybb 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.388 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008344 35
  • 63 (n)
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nf-YB 35
  • 58.33 (n)
  • 64 (a)
Nf-YB 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfyb-1 36
  • 18 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR014C 35
  • 53.56 (n)
  • 60.68 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10429g 35
  • 51.7 (n)
  • 45.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP3 35
  • 56.75 (n)
  • 57.02 (a)
HAP3 36
  • 46 (a)
OneToMany
HAP3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NF-YB10 35
  • 64 (n)
  • 66 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6634 35
barley
(Hordeum vulgare)
Liliopsida Hv.7207 35
rice
(Oryza sativa)
Liliopsida Os.22637 35
Os05g0573500 35
  • 59.52 (n)
  • 67.35 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4075 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.811 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6795 36
  • 51 (a)
OneToOne
Species with no ortholog for NFYB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NFYB Gene

ENSEMBL:
Gene Tree for NFYB (if available)
TreeFam:
Gene Tree for NFYB (if available)

Paralogs for NFYB Gene

Paralogs for NFYB Gene

(3) SIMAP similar genes for NFYB Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NFYB Gene

genes like me logo Genes that share paralogs with NFYB: view

Variants for NFYB Gene

Sequence variations from dbSNP and Humsavar for NFYB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2466551 -- 104,119,140(-) TGCAG(A/C)AGCAA utr-variant-3-prime
rs2468333 -- 104,118,622(+) AATCC(A/G)AGTAC utr-variant-3-prime
rs2723852 -- 104,118,773(-) GTACA(C/G)ACCTT utr-variant-3-prime
rs4257050 -- 104,135,571(+) TATCA(A/G)TAGTA intron-variant
rs7135603 -- 104,125,720(+) GTGCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFYB Gene

Variant ID Type Subtype PubMed ID
nsv819113 CNV Gain 19587683
esv23395 CNV Loss 19812545

Variation tolerance for NFYB Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYB Gene

HapMap Linkage Disequilibrium report
NFYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYB Gene

Disorders for NFYB Gene

Relevant External Links for NFYB

Human Genome Epidemiology (HuGE) Navigator
NFYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYB

No disorders were found for NFYB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYB Gene

Publications for NFYB Gene

  1. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PMID: 9612081) Maity S.N. … de Crombrugghe B. (Trends Biochem. Sci. 1998) 2 3 23 67
  2. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. (PMID: 15964792) Kahle J. … Albig W. (Mol. Cell. Biol. 2005) 3 23
  3. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. (PMID: 15454570) Uramoto H. … Funa K. (J. Cell. Sci. 2004) 3 23
  4. Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development. (PMID: 9660784) Currie R.A. (J. Biol. Chem. 1998) 3 23
  5. Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo. (PMID: 9799238) Li Q. … Wolffe A.P. (EMBO J. 1998) 3 23

Products for NFYB Gene

Sources for NFYB Gene

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