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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFYA Gene

protein-coding   GIFtS: 59
GCID: GC06P041040

Nuclear Transcription Factor Y, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Transcription Factor Y, Alpha1 2     HAP22
Nuclear Transcription Factor Y Subunit A2 3     CAAT-Box DNA Binding Protein Subunit A2
NF-YA2 3     CCAAT-Binding Transcription Factor Subunit B2
CAAT Box DNA-Binding Protein Subunit A2 3     HAP2 CCAAT-Binding Protein2
CBF-A2     Nuclear Transcription Factor Y Subunit Alpha2
CBF-B2     Transcription Factor NF-Y, A Subunit2

External Ids:    HGNC: 78041   Entrez Gene: 48002   Ensembl: ENSG000000011677   OMIM: 1899035   UniProtKB: P235113   

Export aliases for NFYA gene to outside databases

Previous GC identifers: GC06P041042 GC06P041087 GC06P041148 GC06P040758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFYA Gene:
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription
factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a
tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and
affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the
regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product,
either by protein degradation or control of translation. Further regulation is represented by alternative
splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NFYA Gene: 
NFYA (nuclear transcription factor Y, alpha) is a protein-coding gene. Diseases associated with NFYA include megakaryocytic leukemia, and angiomyolipoma, and among its related super-pathways are Activation of Gene Expression by SREBP (SREBF) and Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
for example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFYA gene promoter:
         p53   CUTL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFYA promoter sequence
   Search SABiosciences Chromatin IP Primers for NFYA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFYA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.3

NFYA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041040:  view genomic region     (about GC identifiers)

Start:
41,040,684 bp from pter      End:
41,070,146 bp from pter
Size:
29,463 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit alpha  
Size: 347 amino acids; 36877 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC
must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is
inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox
domain). Interacts with ZFX3
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for NFYA:
4AWL (3D)    
Secondary accessions: Q8IXU0
Alternative splicing: 2 isoforms:  P23511-1   P23511-2   

Explore the universe of human proteins at neXtProt for NFYA: NX_P23511

Explore proteomics data for NFYA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23511

  • NFYA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NFYA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002496.1  NP_068351.1  

    ENSEMBL proteins: 
     ENSP00000345702   ENSP00000229418  
    Reactome Protein details: P23511
    Human Recombinant Protein Products for NFYA: 
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    Novus Biologicals NFYA Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15243141
    GO:0005654nucleoplasm TAS--
    GO:0016602CCAAT-binding factor complex IDA15243141

    NFYA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001289 TF_CBFB
     IPR018362 CCAAT-binding_factor_CS

    Graphical View of Domain Structure for InterPro Entry P23511

    ProtoNet protein and cluster: P23511

    1 Blocks protein domain: IPB001289 CCAAT-binding transcription factor

    UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511
    Similarity: Belongs to the NFYA/HAP2 subunit family
    Similarity: Contains 1 NFYA/HAP2-type DNA-binding domain


    NFYA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFYA_HUMAN, P23511
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
    for example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYA:
    nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a
    variety of promoters,interacting with P/CAF

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10571058
         
    NFYA for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nfya):
     cellular  mortality/aging  no phenotypic analysis  other 

    NFYA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nfyatm1.1Mait for NFYA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NFYA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFYA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFYA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFYA 

    10/492 SABiosciences Target genes for NFYA (see all 492):
    AASS ABI3 ACADSB ACSL3 ADNP2 ADORA2B ADRA2B AGBL5 AGPAT5 AKAP9

    miRNA
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    hsa-miR-549 hsa-miR-140-5p hsa-miR-520f hsa-miR-520e hsa-miR-4254 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNFYA 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NFYA About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.67
    SREBP signalling0.37
    Activation of Gene Expression by SREBP (SREBF)0.67
    2Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency0.55
    5Development Ligand-dependent activation of the ESR1/AP-1 pathway
    Transcription Ligand-dependent activation of the ESR1/SP pathway0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NFYA
        Transcription Ligand-dependent activation of the ESR1/SP pathway


    1 GeneGo (Thomson Reuters) Pathway for NFYA
        Transcription Ligand-dependent activation of the ESR1/SP pathway

    5/6 BioSystems Pathways for NFYA (see all 6)
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    SREBP signalling
    TGF-beta Receptor Signaling Pathway
    Direct p53 effectors

    5/7        Reactome Pathways for NFYA (see all 7)
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    PPARA Activates Gene Expression
    Activation of Gene Expression by SREBP (SREBF)
    Fatty acid, triacylglycerol, and ketone body metabolism


    2         Kegg Pathways  (Kegg details for NFYA):
        Antigen processing and presentation
    Tuberculosis


    NFYA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFYA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for NFYA (P235111, 2, 3 ENSP000003457024) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-389739,EBI-743771 MINT-68389 I2D: score=5 STRING: ENSP00000083182
    NFYBP252081, 3, ENSP000002400554EBI-389739,EBI-389728 I2D: score=4 STRING: ENSP00000240055
    NFYCQ139521, 3, ENSP000003966204EBI-389739,EBI-389755 I2D: score=4 STRING: ENSP00000396620
    TP53P046371, 3, ENSP000002693054EBI-389739,EBI-366083 I2D: score=4 STRING: ENSP00000269305
    SRSF1Q079551, 3, ENSP000002589624EBI-389739,EBI-398920 I2D: score=3 STRING: ENSP00000258962
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IDA15243141
    GO:0006366transcription from RNA polymerase II promoter TAS2000400
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0045893positive regulation of transcription, DNA-dependent ----

    NFYA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NFYA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NFYA

    4 Novoseek inferred chemical compound relationships for NFYA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 42.9 3 14688259 (2)
    serine 11 6 7814413 (4), 12427542 (1), 19302979 (1)
    glutamine 4.06 4 7814413 (4)
    retinoic acid 2.93 1 16223781 (1)

    Search CenterWatch for drugs/clinical trials and news about NFYA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFYA gene (2 alternative transcripts): 
    NM_002505.4  NM_021705.3  

    Unigene Cluster for NFYA:

    Nuclear transcription factor Y, alpha
    Hs.10441  [show with all ESTs]
    Unigene Representative Sequence: NM_002505
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341376(uc003opo.3 uc003opp.3 uc003opq.3) ENST00000353205

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    8/103 QIAGEN miScript miRNA Assays for microRNAs that regulate NFYA (see all 103):
    hsa-miR-549 hsa-miR-140-5p hsa-miR-520f hsa-miR-520e hsa-miR-4254 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p
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    Additional mRNA sequence: 

    AJ420494.1 AK002098.1 AK025201.1 AL137443.1 BC026923.1 BC039244.1 GQ167198.1 M59079.1 
    X59711.1 

    8 DOTS entries:

    DT.308635  DT.100814884  DT.111705  DT.310783  DT.100814885  DT.91753183  DT.92423714  DT.121305348 

    24/196 AceView cDNA sequences (see all 196):

    BX109895 AA425472 CB046263 AU138422 BM716773 AA927051 BU154258 AW075811 
    NM_002505 AA678780 AA485283 AI160445 AI243114 AA779915 AV709446 AI090770 
    BU623017 AW292026 CK823214 BF058095 BM893531 AK002098 AI313501 BM674400 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NFYA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:              -                                                                                 
    SP2:                          -                                                                     
    SP3:              -           -                                                                     
    SP4:                                                        -                                       
    SP5:              -                 -     -     -                                                   


    ECgene alternative splicing isoforms for NFYA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFYA expression in normal human tissues (normalized intensities)      NFYA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTGTCGA
    NFYA Expression
    About this image


    NFYA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             posterior singulate   
     
     Testis (Reproductive System)
             sperm   
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)
             neutrophils   
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells

    See NFYA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFYA

    SOURCE GeneReport for Unigene cluster: Hs.10441
        SABiosciences Custom PCR Arrays for NFYA
    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYA gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfya1 , 5 nuclear transcription factor-Y alpha1, 5 91.45(n)1
    99.71(a)1
      17 (23.99 cM)5
    180441  NM_001110832.11  NP_001104302.11 
     483868855 
    chicken
    (Gallus gallus)
    Aves NFYA1 nuclear transcription factor Y, alpha 84.43(n)
    97.81(a)
      419917  NM_001006325.1  NP_001006325.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFYA6
    Uncharacterized protein
    97(a)
    1 ↔ 1
    4(123388562-123398075)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4182 Xenopus laevis nuclear Y/CCAAT-box binding factor A more 78.85(n)    AF041203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nfya2 nuclear transcription factor Y, alpha 75.12(n)   83915  57052282 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nf-YA1 Nuclear factor Y-box A 51.84(n)
    47.76(a)
      39091  NM_140056.2  NP_648313.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nfya-26
    nfya-16
    Protein NFYA-1
    21(a)
    14(a)
    many → 1
    many → 1
    I(11224836-11233337)
    X(11944358-11946834)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAP2(YGL237C)4 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p more   --   7(53528-52731) 852614  NP_011277.1 
    corn
    (Zea mays)
    Liliopsida CD433238.12   -- 75.09(n)    CD433238.1 


    ENSEMBL Gene Tree for NFYA (if available)
    TreeFam Gene Tree for NFYA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/409 SNPs in NFYA are shown (see all 409)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs786168721,2
    F--41042258(+) TGACTG/CGCCTT 2 -- int11Minor allele frequency- C:0.03NA 120
    rs1460749611,2
    C--41042391(+) GTAGTA/TGTGAT 2 -- int10--------
    rs1388198341,2
    --41042550(+) TGTTTA/TTGGGT 2 -- int10--------
    rs22681881,2
    C,F,A,H--41042590(-) TCTTCA/CTCCCC 2 -- int122Minor allele frequency- C:0.36EA NS NA WA CSA 4200
    rs1156463271,2
    --41042644(+) AATCAC/TCTAGT 2 -- int10--------
    rs1925566081,2
    --41042924(+) TGGAAC/TGTTTT 2 -- int10--------
    rs22681871,2
    C,F,A--41042993(-) AGCTAC/TGATTG 2 -- int17Minor allele frequency- T:0.36NA WA CSA EA 366
    rs760041171,2
    C--41043040(+) CTTCTC/TGTTCT 2 -- int10--------
    rs1847394221,2
    --41043123(+) AAAAAC/TAGGTA 2 -- int10--------
    rs1161495971,2
    F--41043148(+) CAAAAT/ACACTA 2 -- int11Minor allele frequency- A:0.04NA 120

    HapMap Linkage Disequilibrium report for NFYA (41040684 - 41070146 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NFYA: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NFYA
    DNA2.0 Custom Variant and Variant Library Synthesis for NFYA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189903    OMIM disorders: --

    17 diseases for NFYA:    About MalaCards
    megakaryocytic leukemia    angiomyolipoma    acute promyelocytic leukemia    colon adenocarcinoma
    down syndrome    herpes simplex    nasopharyngitis    osteosarcoma
    neuroblastoma    adenocarcinoma    prostate cancer    squamous cell carcinoma
    tuberculosis    prostatitis    leukemia    endotheliitis
    breast cancer


    NFYA for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NFYA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 19265534 (1)

    Human Genome Epidemiology (HuGE) Navigator: NFYA (2 documents)

    Export disorders for NFYA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFYA gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with NFYA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PubMed id 12659632)1, 2, 9 Yamada K.... Miyamoto K. (2003)
    2. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PubMed id 19302979)1, 2, 9 Lim K. and Chang H.I. (2009)
    3. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PubMed id 23332751)1, 2 Nardini M.... Mantovani R. (2013)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)1, 2 Kawata H.... Miyamoto K. (2003)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Identification of proteins that interact with NF-YA. (PubMed id 10571058)1, 2 Yamada K.... Granner D.K. (1999)
    8. Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. (PubMed id 10441475)1, 2 Yamada K.... Granner D.K. (1999)
    9. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PubMed id 9612081)1, 3 Maity S.N. and de Crombrugghe B. (1998)
    10. Evolutionary variation of the CCAAT-binding transcription factor NF- Y. (PubMed id 1549471)1, 2 Li X.-Y.... Mathis D. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4800 HGNC: 7804 AceView: NFYA Ensembl:ENSG00000001167 euGenes: HUgn4800
    ECgene: NFYA Kegg: 4800 H-InvDB: NFYA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFYA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFYA gene:
    Search GeneIP for patents involving NFYA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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