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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFYA Gene

protein-coding   GIFtS: 59
GCID: GC06P041040

nuclear transcription factor Y, alpha

 Explore 18 diseases affiliated with
NFYA via our new
 Human Malady Compendium 
Biological research products
for NFYA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nuclear Transcription Factor Y, Alpha1 2     CBF-A2
NF-YA1 2 3     CAAT-Box DNA Binding Protein Subunit A2
CBF-B1 2     CCAAT-Binding Transcription Factor Subunit B2
HAP21 2     HAP2 CCAAT-Binding Protein2
Nuclear Transcription Factor Y Subunit A2 3     Nuclear Transcription Factor Y Subunit Alpha2
CAAT Box DNA-Binding Protein Subunit A2 3     Transcription Factor NF-Y, A Subunit2

External Ids:    HGNC: 78041   Entrez Gene: 48002   Ensembl: ENSG000000011677   OMIM: 1899035   UniProtKB: P235113   

Export aliases for NFYA gene to outside databases

Previous GC identifers: GC06P041042 GC06P041087 GC06P041148 GC06P040758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFYA:
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor
that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer
composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The
sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit.
In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation
or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation
domain, with clear tissue-specific preferences for the two isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for
example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYA


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFYA gene promoter:
         p53   CUTL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFYA promoter sequence
   Search SABiosciences Chromatin IP Primers for NFYA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFYA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.3

NFYA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041040:  view genomic region     (about GC identifiers)

Start:
41,040,684 bp from pter      End:
41,070,146 bp from pter
Size:
29,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit alpha  
Size: 347 amino acids; 36877 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must
interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by
glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with
ZFX3
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for NFYA:
4AWL (3D)    
Secondary accessions: Q8IXU0
Alternative splicing: 2 isoforms:  P23511-1   P23511-2   

Explore the universe of human proteins at neXtProt for NFYA: NX_P23511

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23511

  • NFYA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002496.1  NP_068351.1  

    ENSEMBL proteins: 
     ENSP00000345702   ENSP00000229418  
    Reactome Protein details: P23511
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    Novus Biologicals NFYA Proteins
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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15964792
    GO:0016602CCAAT-binding factor complex IDA15243141


    NFYA for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NFYA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001289 TF_CBFB
     IPR018362 CCAAT-binding_factor_CS

    Graphical View of Domain Structure for InterPro Entry P23511

    ProtoNet protein and cluster: P23511

    1 Blocks protein family: IPB001289 CCAAT-binding transcription factor

    UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511
    Similarity: Belongs to the NFYA/HAP2 subunit family
    Similarity: Contains 1 NFYA/HAP2-type DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for
    example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYA:
    nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a
    variety of promoters,interacting with P/CAF

    10/503 SABiosciences Target genes for NFYA (see all 503):
    AASS ABI3 ACADSB ACSL3 ADNP2 ADORA2B ADRA2B AGBL5 AGPAT5 AKAP9

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    8/103 QIAGEN miScript miRNA Assays for microRNAs that regulate NFYA (see all 103):
    hsa-miR-549 hsa-miR-140-5p hsa-miR-520f hsa-miR-520e hsa-miR-4254 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNFYA 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--


    NFYA for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nfyatm1.1Mait for NFYA
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nfya):
     cellular  mortality/aging  no phenotypic analysis  other 

    NFYA for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of Mevalonate Kinase (MVK)
    Expression of Mevalonate Kinase (MVK)1.00
    Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)0.75
    Expression of 7-Dehydrocholesterol Reductase (DHCR7)0.75
    Expression of Phosphomevalonate Kinase (PMVK)0.75
    Expression of Lanosterol Demethylase (CYP51A1)0.75
    Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)0.75
    Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)0.75
    Expression of Fatty Acid Synthase (FASN)0.62
    2Expression of Lathosterol Oxidase (SC5D, SC5DL)
    Expression of Lathosterol Oxidase (SC5D, SC5DL)1.00
    Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)0.71
    Expression of Farnesyl Diphosphate Synthase (FDPS)0.71
    Expression of Squalene Monooxygenase (SQLE)0.71
    Expression of TM7SF20.71
    Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)0.57
    Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)0.71
    3Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    4Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)1.00
    SREBP signalling0.46
    Activation of Gene Expression by SREBP (SREBF)0.67
    5Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NFYA
        Transcription Ligand-dependent activation of the ESR1/SP pathway


    1 GeneGo (Thomson Reuters) Pathway for NFYA
        Transcription Ligand-dependent activation of the ESR1/SP pathway

    5/6 BioSystems Pathways for NFYA (see all 6
        SIDS Susceptibility Pathways
    SREBP signalling
    Wnt Signaling Pathway and Pluripotency
    TGF-beta Receptor Signaling Pathway
    Validated targets of C-MYC transcriptional repression

    5/22        Reactome Pathways for NFYA (see all 22)
        Expression of Fatty Acid Synthase (FASN)
    Expression of Mevalonate Kinase (MVK)
    Expression of Squalene Monooxygenase (SQLE)
    Metabolism
    Expression of 7-Dehydrocholesterol Reductase (DHCR7)


    2         Kegg Pathways  (Kegg details for NFYA):
        Antigen processing and presentation
    Tuberculosis


    NFYA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFYA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for NFYA (P235111, 2, 3 ENSP000003457024) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-389739,EBI-743771 MINT-68389 I2D: score=5 STRING: ENSP00000083182
    NFYBP252081, 3, ENSP000002400554EBI-389739,EBI-389728 I2D: score=4 STRING: ENSP00000240055
    NFYCQ139521, 3, ENSP000003966204EBI-389739,EBI-389755 I2D: score=4 STRING: ENSP00000396620
    TP53P046371, 3, ENSP000002693054EBI-389739,EBI-366083 I2D: score=4 STRING: ENSP00000269305
    SRSF1Q079551, 3, ENSP000002589624EBI-389739,EBI-398920 I2D: score=3 STRING: ENSP00000258962
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IDA15243141
    GO:0006366transcription from RNA polymerase II promoter TAS2000400
    GO:0045893positive regulation of transcription, DNA-dependent ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--


    NFYA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NFYA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFYA
    4 Novoseek chemical compound relationships for NFYA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 42.9 3 14688259 (2)
    serine 11 6 7814413 (4), 12427542 (1), 19302979 (1)
    glutamine 4.06 4 7814413 (4)
    retinoic acid 2.93 1 16223781 (1)

    Search CenterWatch for drugs/clinical trials and news about NFYA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFYA gene (2 alternative transcripts): 
    NM_002505.4  NM_021705.3  

    Unigene Cluster for NFYA:

    Nuclear transcription factor Y, alpha
    Hs.10441  [show with all ESTs]
    Unigene Representative Sequence: NM_002505
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341376(uc003opo.3 uc003opp.3 uc003opq.3) ENST00000353205


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    hsa-miR-549 hsa-miR-140-5p hsa-miR-520f hsa-miR-520e hsa-miR-4254 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p
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    Additional cDNA sequence: 

    AJ420494.1 AK002098.1 AK025201.1 AL137443.1 BC026923.1 BC039244.1 M59079.1 X59711.1 

    8 DOTS entries:

    DT.308635  DT.100814884  DT.111705  DT.310783  DT.100814885  DT.91753183  DT.92423714  DT.121305348 

    24/196 AceView cDNA sequences (see all 196):

    CK823213 BX109895 AA736741 Z45635 BX108428 AI376542 BC026923 AK025201 
    CA397189 AA382555 AW292026 NM_002505 AA779915 AA425472 AL044113 AA485283 
    AI478773 BU623017 BM468488 AV728234 AI809865 CB046263 AI090770 AI313501 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NFYA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:              -                                                                                 
    SP2:                          -                                                                     
    SP3:              -           -                                                                     
    SP4:                                                        -                                       
    SP5:              -                 -     -     -                                                   


    ECgene alternative splicing isoforms for NFYA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFYA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGTGTCGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NFYA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFYA

    SOURCE GeneReport for Unigene cluster: Hs.10441
        SABiosciences Custom PCR Arrays for NFYA
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYA gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfya1 , 5 nuclear transcription factor-Y alpha1, 5 91.45(n)1
    99.71(a)1
      17 (23.99 cM)5
    180441  NM_001110832.11  NP_001104302.11 
     483868855 
    chicken
    (Gallus gallus)
    Aves NFYA1 nuclear transcription factor Y, alpha 84.43(n)
    97.81(a)
      419917  NM_001006325.1  NP_001006325.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFYA6
    --
    97(a)
    1 ↔ 1
    4(123388605-123398075)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4182 Xenopus laevis nuclear Y/CCAAT-box binding factor A more 78.85(n)    AF041203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nfya2 nuclear transcription factor Y, alpha 75.12(n)   83915  57052282 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nf-YA1 Nuclear factor Y-box A 51.84(n)
    47.76(a)
      39091  NM_140056.2  NP_648313.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nfya-26
    nfya-16
    Nuclear transcription Factor Y, A (alpha) subunit ...
    Nuclear transcription Factor Y, A (alpha) subunit ...
    17(a)
    13(a)
    many → 1
    many → 1
    I(11224828-11233329)
    X(11944290-11946766)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NF-YA76
    NF-YA46
    (see all 10)
    nuclear transcription factor Y subunit A-4
    (see all 10)
    26(a)
    24(a)
    (see all 10)
    many → 1
    many → 1
    (see all 10)
    1(10804450-10806319)
    2(14649767-14651627)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 11)
    nuclear transcription factor Y subunit, putative, ...
    nuclear transcription factor Y subunit, putative, ...
    (see all 11)
    27(a)
    26(a)
    (see all 11)
    many → 1
    many → 1
    (see all 11)
    8(5596557-5600332)
    3(4000991-4004424)


    ENSEMBL Gene Tree for NFYA (if available)
    TreeFam Gene Tree for NFYA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/432 NCBI SNPs in NFYA are shown (see all 432    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863842541,2
    --41038721(+) TAAACA/GTCTAA 3 -- us2k1 int10--------
    rs1909747161,2
    --41038760(+) CTTAAA/GAACAT 3 -- us2k1 int10--------
    rs131913231,2
    C,F,--41038845(+) GCAAAC/TCAGGT 3 -- int1 us2k1 tfbs310Minor allele frequency- T:0.25NA WA CSA EA EU 1657
    rs1817713431,2
    C,--41039032(+) GCAAAA/GGAAAA 3 -- us2k1 int10--------
    rs1395723471,2
    --41039071(+) ACTAAC/GCTATT 3 -- us2k1 int10--------
    rs560338651,2
    F,--41039100(+) CCCACG/AACTAC 3 -- int1 us2k12Minor allele frequency- A:0.11WA NA 238
    rs2005072301,2
    --41039312(+) CACCAA/GTAAGT 3 -- int1 us2k10--------
    rs1488991311,2
    --41039572(+) CTGGGG/TCAAAG 3 -- int1 us2k10--------
    rs2009856921,2
    --41039603(+) GAGGC-/TGTCTC 3 -- int1 us2k10--------
    rs1469387331,2
    --41039622(+) CTCATC/TTCGTG 3 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for NFYA (41040684 - 41070146 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NFYA: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFYA
    DNA2.0 Custom Variant and Variant Library Synthesis for NFYA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NFYA for disorders           About GeneDecksing

    OMIM gene information: 189903    OMIM disorders: --

    18 diseases for NFYA:    About MalaCards
    acute promyelocytic leukemia    megakaryocytic leukemia    herpes simplex    angiomyolipoma
    squamous cell carcinoma    embryonal carcinoma    down syndrome    colon adenocarcinoma
    nasopharyngitis    leukemia    osteosarcoma    adenocarcinoma
    prostate cancer    breast cancer    carcinoma    neuroblastoma
    prostatitis    tuberculosis

    1 Novoseek disease relationship for NFYA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 19265534 (1)

    Human Genome Epidemiology (HuGE) Navigator: NFYA (2 documents)

    Export disorders for NFYA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFYA gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with NFYA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PubMed id 12659632)1, 2, 9 Yamada K.... Miyamoto K. (2003)
    2. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PubMed id 19302979)1, 2, 9 Lim K. and Chang H.I. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)1, 2 Kawata H.... Miyamoto K. (2003)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Identification of proteins that interact with NF-YA. (PubMed id 10571058)1, 2 Yamada K.... Granner D.K. (1999)
    7. Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. (PubMed id 10441475)1, 2 Yamada K.... Granner D.K. (1999)
    8. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PubMed id 9612081)1, 3 Maity S.N. and de Crombrugghe B. (1998)
    9. Evolutionary variation of the CCAAT-binding transcription factor NF- Y. (PubMed id 1549471)1, 2 Li X.-Y.... Mathis D. (1992)
    10. A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. (PubMed id 2000400)1, 2 Becker D.M.... Guarente L. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4800 HGNC: 7804 AceView: NFYA Ensembl:ENSG00000001167 euGenes: HUgn4800
    ECgene: NFYA Kegg: 4800 H-InvDB: NFYA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFYA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFYA gene:
    Search GeneIP for patents involving NFYA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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