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Aliases for NFYA Gene

Aliases for NFYA Gene

  • Nuclear Transcription Factor Y, Alpha 2 3
  • Nuclear Transcription Factor Y Subunit A 3 4
  • CAAT Box DNA-Binding Protein Subunit A 3 4
  • NF-YA 3 4
  • CCAAT-Binding Transcription Factor Subunit B 3
  • CAAT-Box DNA Binding Protein Subunit A 3
  • Transcription Factor NF-Y, A Subunit 3
  • HAP2 CCAAT-Binding Protein 3
  • CBF-A 3
  • CBF-B 3
  • HAP2 3

External Ids for NFYA Gene

Previous GeneCards Identifiers for NFYA Gene

  • GC06P041042
  • GC06P041087
  • GC06P041148
  • GC06P040758

Summaries for NFYA Gene

Entrez Gene Summary for NFYA Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYA Gene

NFYA (Nuclear Transcription Factor Y, Alpha) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for NFYA Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Wiki entry for NFYA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYA Gene

Genomics for NFYA Gene

Regulatory Elements for NFYA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFYA Gene

Chromosome:
6
Start:
41,072,945 bp from pter
End:
41,102,407 bp from pter
Size:
29,463 bases
Orientation:
Plus strand

Genomic View for NFYA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NFYA Gene

Proteins for NFYA Gene

  • Protein details for NFYA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23511-NFYA_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit alpha
    Protein Accession:
    P23511
    Secondary Accessions:
    • Q8IXU0

    Protein attributes for NFYA Gene

    Size:
    347 amino acids
    Molecular mass:
    36877 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3.

    Three dimensional structures from OCA and Proteopedia for NFYA Gene

    Alternative splice isoforms for NFYA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFYA Gene

Proteomics data for NFYA Gene at MOPED

Post-translational modifications for NFYA Gene

  • Ubiquitination at Lys 270
  • Modification sites at PhosphoSitePlus

Other Protein References for NFYA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NFYA Gene

Domains & Families for NFYA Gene

Protein Domains for NFYA Gene

Suggested Antigen Peptide Sequences for NFYA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23511

UniProtKB/Swiss-Prot:

NFYA_HUMAN :
  • Contains 1 NFYA/HAP2-type DNA-binding domain.
  • Belongs to the NFYA/HAP2 subunit family.
Domain:
  • Contains 1 NFYA/HAP2-type DNA-binding domain.
Family:
  • Belongs to the NFYA/HAP2 subunit family.
genes like me logo Genes that share domains with NFYA: view

No data available for Gene Families for NFYA Gene

Function for NFYA Gene

Molecular function for NFYA Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,interacting with P/CAF
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Ontology (GO) - Molecular Function for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003677 DNA binding IDA 15243141
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 10571058
GO:0044212 contributes_to transcription regulatory region DNA binding IDA 11256944
genes like me logo Genes that share ontologies with NFYA: view
genes like me logo Genes that share phenotypes with NFYA: view

Animal Models for NFYA Gene

MGI Knock Outs for NFYA:

Animal Model Products

Transcription Factor Targets for NFYA Gene

Selected GeneGlobe predicted Target genes for NFYA
Targeted motifs for NFYA Gene
HOMER Transcription Factor Regulatory Elements motif NFYA
  • Consensus sequence: AGCCAATCGG Submotif: canonical Cell Type: NA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFYA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for NFYA Gene

Localization for NFYA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFYA Gene COMPARTMENTS Subcellular localization image for NFYA gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15243141
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
genes like me logo Genes that share ontologies with NFYA: view

Pathways & Interactions for NFYA Gene

genes like me logo Genes that share pathways with NFYA: view

Gene Ontology (GO) - Biological Process for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006366 transcription from RNA polymerase II promoter TAS 2000400
GO:0044281 small molecule metabolic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with NFYA: view

No data available for SIGNOR curated interactions for NFYA Gene

Drugs & Compounds for NFYA Gene

(2) Drugs for NFYA Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glutamine Nutra 137
serine Nutra 420

(2) Additional Compounds for NFYA Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Methylmethanesulfonate
retinoic acid
302-79-4
genes like me logo Genes that share compounds with NFYA: view

Transcripts for NFYA Gene

Unigene Clusters for NFYA Gene

Nuclear transcription factor Y, alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFYA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFYA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for NFYA Gene

GeneLoc Exon Structure for
NFYA
ECgene alternative splicing isoforms for
NFYA

Expression for NFYA Gene

mRNA expression in normal human tissues for NFYA Gene

Protein differential expression in normal tissues from HIPED for NFYA Gene

This gene is overexpressed in Pancreas (15.2), CD8 Tcells (8.2), Blymphocyte (7.7), Peripheral blood mononuclear cells (7.4), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFYA Gene



SOURCE GeneReport for Unigene cluster for NFYA Gene Hs.10441

genes like me logo Genes that share expression patterns with NFYA: view

Protein tissue co-expression partners for NFYA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFYA Gene

Orthologs for NFYA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NFYA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFYA 35
  • 93.65 (n)
  • 99.41 (a)
NFYA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFYA 35
  • 95.1 (n)
  • 100 (a)
NFYA 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfya 35
  • 91.45 (n)
  • 99.71 (a)
Nfya 16
Nfya 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFYA 35
  • 99.52 (n)
  • 100 (a)
NFYA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfya 35
  • 91.3 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia NFYA 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFYA 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFYA 35
  • 82.6 (n)
  • 94.16 (a)
NFYA 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFYA 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76011 35
nfya 35
  • 78.2 (n)
  • 92.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.418 35
zebrafish
(Danio rerio)
Actinopterygii nfya 35
nfyal 35
  • 75 (n)
  • 85 (a)
nfya 36
  • 79 (a)
OneToMany
nfyal 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nf-YA 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfya-1 36
  • 15 (a)
OneToMany
nfya-2 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP2 36
  • 28 (a)
OneToOne
HAP2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for NFYA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFYA Gene

ENSEMBL:
Gene Tree for NFYA (if available)
TreeFam:
Gene Tree for NFYA (if available)

Paralogs for NFYA Gene

No data available for Paralogs for NFYA Gene

Variants for NFYA Gene

Sequence variations from dbSNP and Humsavar for NFYA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs717883 -- 41,077,531(+) GTTTA(C/T)AGCCA intron-variant
rs767497 -- 41,079,868(-) CTTTT(A/C)TATAT intron-variant
rs1042256 -- 41,097,818(+) CTAGA(A/C/T)AGCAT utr-variant-3-prime
rs1059008 -- 41,075,985(+) CTGTA(G/T)GATGA intron-variant
rs1883596 -- 41,098,559(+) TGGAA(A/G)GCACT utr-variant-3-prime

Variation tolerance for NFYA Gene

Residual Variation Intolerance Score: 23.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYA Gene

HapMap Linkage Disequilibrium report
NFYA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NFYA Gene

Disorders for NFYA Gene

Relevant External Links for NFYA

Human Genome Epidemiology (HuGE) Navigator
NFYA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYA
genes like me logo Genes that share disorders with NFYA: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYA Gene

Publications for NFYA Gene

  1. The CCAAT box binding transcription factor, nuclear factor-Y (NF-Y) regulates transcription of human aldo-keto reductase 1C1 (AKR1C1) gene. (PMID: 20338228) Pallai R. … Parekh H.K. (Gene 2010) 23 67
  2. Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients. (PMID: 19265534) Habib S.L. (Mol. Cancer 2009) 23 67
  3. The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension. (PMID: 19348505) Wienk H. … Folkers G.E. (Biochemistry 2009) 23 67
  4. Members of miR-169 family are induced by high salinity and transiently inhibit the NF-YA transcription factor. (PMID: 19351418) Zhao B. … Jin Y. (BMC Mol. Biol. 2009) 23 67
  5. NF-YC complexity is generated by dual promoters and alternative splicing. (PMID: 19690168) Ceribelli M. … Mantovani R. (J. Biol. Chem. 2009) 23 67

Products for NFYA Gene

Sources for NFYA Gene

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