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Aliases for NFYA Gene

Aliases for NFYA Gene

  • Nuclear Transcription Factor Y Subunit Alpha 2 3 5
  • Nuclear Transcription Factor Y Subunit A 3 4
  • Nuclear Transcription Factor Y, Alpha 2 3
  • NF-YA 3 4
  • CCAAT-Binding Transcription Factor Subunit B 3
  • CAAT-Box DNA Binding Protein Subunit A 3
  • CAAT Box DNA-Binding Protein Subunit A 4
  • Transcription Factor NF-Y, A Subunit 3
  • HAP2 CCAAT-Binding Protein 3
  • CBF-A 3
  • CBF-B 3
  • HAP2 3

External Ids for NFYA Gene

Previous GeneCards Identifiers for NFYA Gene

  • GC06P041042
  • GC06P041087
  • GC06P041148
  • GC06P041040
  • GC06P040758
  • GC06P041074

Summaries for NFYA Gene

Entrez Gene Summary for NFYA Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYA Gene

NFYA (Nuclear Transcription Factor Y Subunit Alpha) is a Protein Coding gene. Among its related pathways are Allograft rejection and Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for NFYA Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Wiki entry for NFYA Gene

Additional gene information for NFYA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYA Gene

Genomics for NFYA Gene

Regulatory Elements for NFYA Gene

Enhancers for NFYA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H041198 1.5 Ensembl ENCODE dbSUPER 10.5 +128.5 128486 6 HDGF ATF1 ARNT TCF12 GATA2 RUNX3 NCOA1 ZNF592 MBD2 SMARCA4 TREML4 TREML3P TREM2 USP49 ADCY10P1 NFYA TREML5P TREML1 ENSG00000218809 TREML2
GH06H041487 1.4 Ensembl ENCODE dbSUPER 10.4 +416.0 415973 1 HDGF PKNOX1 ZNF473 ZSCAN4 KLF17 GLIS2 FOS RCOR1 RUNX3 IKZF2 NFYA GC06M041477 LINC01276
GH06H041271 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +199.2 199214 2 CTCF ZFP64 MAX ZKSCAN1 GABPA POLR2A CREB1 MYC TREM1 TREML4 NFYA TREML3P TFEB TREML2 TREML1 ENSG00000218809 GC06M041280
GH06H041278 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.6 +206.3 206255 0 HDGF ATF1 ARNT TCF12 ZNF766 GATA2 ZNF143 ATF7 RUNX3 MXD4 TREM1 USP49 NFYA TFEB TREML2 TREML4 GC06M041280 ENSG00000218809
GH06H041181 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.5 +109.7 109688 1 CTCF MAX RAD21 TCF12 GATA2 SMC3 ZNF143 ZNF654 L3MBTL2 USF2 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 TREM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFYA on UCSC Golden Path with GeneCards custom track

Promoters for NFYA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196789 55 3601 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZNF610 GLIS1 RCOR2

Genomic Location for NFYA Gene

Chromosome:
6
Start:
41,072,945 bp from pter
End:
41,102,407 bp from pter
Size:
29,463 bases
Orientation:
Plus strand

Genomic View for NFYA Gene

Genes around NFYA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYA Gene

Proteins for NFYA Gene

  • Protein details for NFYA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23511-NFYA_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit alpha
    Protein Accession:
    P23511
    Secondary Accessions:
    • Q8IXU0

    Protein attributes for NFYA Gene

    Size:
    347 amino acids
    Molecular mass:
    36877 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3.

    Three dimensional structures from OCA and Proteopedia for NFYA Gene

    Alternative splice isoforms for NFYA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFYA Gene

Post-translational modifications for NFYA Gene

  • Ubiquitination at Lys270
  • Modification sites at PhosphoSitePlus

Other Protein References for NFYA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NFYA Gene

Domains & Families for NFYA Gene

Gene Families for NFYA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFYA Gene

Suggested Antigen Peptide Sequences for NFYA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23511

UniProtKB/Swiss-Prot:

NFYA_HUMAN :
  • Belongs to the NFYA/HAP2 subunit family.
Family:
  • Belongs to the NFYA/HAP2 subunit family.
genes like me logo Genes that share domains with NFYA: view

Function for NFYA Gene

Molecular function for NFYA Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,interacting with P/CAF
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Phenotypes From GWAS Catalog for NFYA Gene

Gene Ontology (GO) - Molecular Function for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 11256944
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003677 DNA binding IDA 15243141
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS --
GO:0005515 protein binding IPI 10571058
genes like me logo Genes that share ontologies with NFYA: view
genes like me logo Genes that share phenotypes with NFYA: view

Animal Models for NFYA Gene

MGI Knock Outs for NFYA:

Animal Model Products

CRISPR Products

Transcription Factor Targets for NFYA Gene

Selected GeneGlobe predicted Target genes for NFYA
Targeted motifs for NFYA Gene
HOMER Transcription Factor Regulatory Elements motif NFYA
  • Consensus sequence: AGCCAATCGG Submotif: canonical Cell Type: NA

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFYA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for NFYA Gene

Localization for NFYA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYA gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 15243141
GO:0005654 nucleoplasm TAS --
GO:0016602 CCAAT-binding factor complex IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
GO:0090575 RNA polymerase II transcription factor complex IDA 11256944
genes like me logo Genes that share ontologies with NFYA: view

Pathways & Interactions for NFYA Gene

genes like me logo Genes that share pathways with NFYA: view

Gene Ontology (GO) - Biological Process for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0006366 transcription from RNA polymerase II promoter TAS 2000400
GO:0045540 regulation of cholesterol biosynthetic process TAS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with NFYA: view

No data available for SIGNOR curated interactions for NFYA Gene

Drugs & Compounds for NFYA Gene

(2) Drugs for NFYA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NFYA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFYA: view

Transcripts for NFYA Gene

mRNA/cDNA for NFYA Gene

Unigene Clusters for NFYA Gene

Nuclear transcription factor Y, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFYA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NFYA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for NFYA Gene

GeneLoc Exon Structure for
NFYA
ECgene alternative splicing isoforms for
NFYA

Expression for NFYA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFYA Gene

Protein differential expression in normal tissues from HIPED for NFYA Gene

This gene is overexpressed in Pancreas (15.2), CD8 Tcells (8.2), Blymphocyte (7.7), Peripheral blood mononuclear cells (7.4), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFYA Gene



Protein tissue co-expression partners for NFYA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFYA Gene:

NFYA

SOURCE GeneReport for Unigene cluster for NFYA Gene:

Hs.10441

Evidence on tissue expression from TISSUES for NFYA Gene

  • Liver(4.4)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with NFYA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFYA Gene

Orthologs for NFYA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NFYA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYA 33 34
  • 99.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFYA 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFYA 33 34
  • 95.1 (n)
oppossum
(Monodelphis domestica)
Mammalia NFYA 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYA 33 34
  • 93.65 (n)
mouse
(Mus musculus)
Mammalia Nfya 33 16 34
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Nfya 33
  • 91.3 (n)
chicken
(Gallus gallus)
Aves NFYA 33 34
  • 82.6 (n)
lizard
(Anolis carolinensis)
Reptilia NFYA 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfya 33
  • 78.2 (n)
MGC76011 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.418 33
zebrafish
(Danio rerio)
Actinopterygii nfya 33 34
  • 79 (a)
nfyal 33 34
  • 75 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nf-YA 34
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfya-2 34
  • 21 (a)
OneToMany
nfya-1 34
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP2 34 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToOne
Species where no ortholog for NFYA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFYA Gene

ENSEMBL:
Gene Tree for NFYA (if available)
TreeFam:
Gene Tree for NFYA (if available)

Paralogs for NFYA Gene

No data available for Paralogs for NFYA Gene

Variants for NFYA Gene

Sequence variations from dbSNP and Humsavar for NFYA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000074411 -- 41,089,112(+) CCAAG(C/T)AGCTG intron-variant
rs1000078279 -- 41,102,389(+) GTATT(C/G)TCTTC intron-variant, utr-variant-3-prime
rs1000128522 -- 41,096,700(+) GCGGA(A/G)TGTTG intron-variant
rs1000201091 -- 41,094,838(+) GAGGG(C/T)TGAGA intron-variant
rs1000225000 -- 41,086,060(+) TCAGC(A/C/G)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFYA Gene

Variant ID Type Subtype PubMed ID
nsv1117437 CNV tandem duplication 24896259
nsv602970 CNV gain 21841781

Variation tolerance for NFYA Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYA Gene

Disorders for NFYA Gene

Relevant External Links for NFYA

Human Genome Epidemiology (HuGE) Navigator
NFYA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYA

No disorders were found for NFYA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYA Gene

Publications for NFYA Gene

  1. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PMID: 19302979) Lim K … Chang HI (Biochemical and biophysical research communications 2009) 3 4 22 60
  2. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PMID: 12659632) Yamada K … Miyamoto K (The Biochemical journal 2003) 3 4 22 60
  3. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M … Mantovani R (Cell 2013) 3 4 60
  4. Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. (PMID: 16959611) Di Agostino S … Piaggio G (Cancer cell 2006) 3 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for NFYA Gene

Sources for NFYA Gene

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