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Aliases for NFYA Gene

Aliases for NFYA Gene

  • Nuclear Transcription Factor Y Subunit Alpha 2 3 5
  • Nuclear Transcription Factor Y Subunit A 3 4
  • Nuclear Transcription Factor Y, Alpha 2 3
  • NF-YA 3 4
  • CCAAT-Binding Transcription Factor Subunit B 3
  • CAAT-Box DNA Binding Protein Subunit A 3
  • CAAT Box DNA-Binding Protein Subunit A 4
  • Transcription Factor NF-Y, A Subunit 3
  • HAP2 CCAAT-Binding Protein 3
  • CBF-A 3
  • CBF-B 3
  • HAP2 3

External Ids for NFYA Gene

Previous GeneCards Identifiers for NFYA Gene

  • GC06P041042
  • GC06P041087
  • GC06P041148
  • GC06P040758

Summaries for NFYA Gene

Entrez Gene Summary for NFYA Gene

  • The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFYA Gene

NFYA (Nuclear Transcription Factor Y Subunit Alpha) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for NFYA Gene

  • Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Wiki entry for NFYA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFYA Gene

Genomics for NFYA Gene

Regulatory Elements for NFYA Gene

Enhancers for NFYA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F041278 1.6 FANTOM5 Ensembl ENCODE 7.5 +206.9 206904 2.9 HDGF ATF1 ARNT CREB3L1 YBX1 GATA2 ZNF143 MXD4 MIER2 REST TREM1 NFYA TFEB ADCY10P1 TREML2 TREML4 GC06M041280 ENSG00000218809
GH06F041270 1.2 FANTOM5 Ensembl ENCODE 9.7 +199.1 199114 2.5 CTCF ZFP64 MAX MYC EZH2 TREM1 TREML4 NFYA TREML3P TFEB TREML2 TREML1 ENSG00000218809 GC06M041280
GH06F041181 1.3 FANTOM5 Ensembl ENCODE 8.5 +109.7 109657 2.0 CTCF ESRRA MAX YBX1 RAD21 GATA2 SMC3 NR2F6 TCF7L2 EGR2 TREM1 ADCY10P1 TREML1 TREML4 NFYA TREML2 TREM2
GH06F040995 1.3 Ensembl ENCODE 4.9 -75.0 -74990 5.3 PKNOX1 ATF1 ARID4B FEZF1 SLC30A9 GLIS2 ZNF416 ZNF143 FOS JUNB TSPO2 UNC5CL NFYA LOC101929555 GC06P040912
GH06F041283 1.3 FANTOM5 Ensembl ENCODE 4.8 +212.9 212858 4.0 CTCF USF1 ETV1 RFX5 ZFHX2 NFYB TRIM24 EGR2 RFX1 HLF TREM1 TFEB NFYA TREML2 TREML4 GC06M041280
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFYA on UCSC Golden Path with GeneCards custom track

Promoters for NFYA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001216457 55 4401 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1

Genomic Location for NFYA Gene

Chromosome:
6
Start:
41,072,945 bp from pter
End:
41,102,407 bp from pter
Size:
29,463 bases
Orientation:
Plus strand

Genomic View for NFYA Gene

Genes around NFYA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFYA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFYA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFYA Gene

Proteins for NFYA Gene

  • Protein details for NFYA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23511-NFYA_HUMAN
    Recommended name:
    Nuclear transcription factor Y subunit alpha
    Protein Accession:
    P23511
    Secondary Accessions:
    • Q8IXU0

    Protein attributes for NFYA Gene

    Size:
    347 amino acids
    Molecular mass:
    36877 Da
    Quaternary structure:
    • Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3.

    Three dimensional structures from OCA and Proteopedia for NFYA Gene

    Alternative splice isoforms for NFYA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFYA Gene

Post-translational modifications for NFYA Gene

  • Ubiquitination at Lys 270
  • Modification sites at PhosphoSitePlus

Other Protein References for NFYA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NFYA Gene

Domains & Families for NFYA Gene

Protein Domains for NFYA Gene

Suggested Antigen Peptide Sequences for NFYA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23511

UniProtKB/Swiss-Prot:

NFYA_HUMAN :
  • Contains 1 NFYA/HAP2-type DNA-binding domain.
  • Belongs to the NFYA/HAP2 subunit family.
Domain:
  • Contains 1 NFYA/HAP2-type DNA-binding domain.
Family:
  • Belongs to the NFYA/HAP2 subunit family.
genes like me logo Genes that share domains with NFYA: view

No data available for Gene Families for NFYA Gene

Function for NFYA Gene

Molecular function for NFYA Gene

GENATLAS Biochemistry:
nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a variety of promoters,interacting with P/CAF
UniProtKB/Swiss-Prot Function:
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5-CCAAT-3 box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Ontology (GO) - Molecular Function for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003677 DNA binding IEA,IDA 15243141
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 10571058
GO:0044212 contributes_to transcription regulatory region DNA binding IDA 11256944
genes like me logo Genes that share ontologies with NFYA: view
genes like me logo Genes that share phenotypes with NFYA: view

Animal Models for NFYA Gene

MGI Knock Outs for NFYA:

Animal Model Products

Transcription Factor Targets for NFYA Gene

Selected GeneGlobe predicted Target genes for NFYA
Targeted motifs for NFYA Gene
HOMER Transcription Factor Regulatory Elements motif NFYA
  • Consensus sequence: AGCCAATCGG Submotif: canonical Cell Type: NA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for NFYA Gene

Localization for NFYA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFYA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFYA gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15243141
GO:0005654 nucleoplasm IDA,TAS --
GO:0016602 CCAAT-binding factor complex IEA,IDA 15243141
GO:0032993 protein-DNA complex IDA 11256944
genes like me logo Genes that share ontologies with NFYA: view

Pathways & Interactions for NFYA Gene

genes like me logo Genes that share pathways with NFYA: view

Gene Ontology (GO) - Biological Process for NFYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 15243141
GO:0006366 transcription from RNA polymerase II promoter TAS 2000400
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with NFYA: view

No data available for SIGNOR curated interactions for NFYA Gene

Drugs & Compounds for NFYA Gene

(2) Drugs for NFYA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NFYA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFYA: view

Transcripts for NFYA Gene

mRNA/cDNA for NFYA Gene

Unigene Clusters for NFYA Gene

Nuclear transcription factor Y, alpha:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFYA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - - - -

Relevant External Links for NFYA Gene

GeneLoc Exon Structure for
NFYA
ECgene alternative splicing isoforms for
NFYA

Expression for NFYA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFYA Gene

Protein differential expression in normal tissues from HIPED for NFYA Gene

This gene is overexpressed in Pancreas (15.2), CD8 Tcells (8.2), Blymphocyte (7.7), Peripheral blood mononuclear cells (7.4), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFYA Gene



Protein tissue co-expression partners for NFYA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFYA Gene:

NFYA

SOURCE GeneReport for Unigene cluster for NFYA Gene:

Hs.10441
genes like me logo Genes that share expression patterns with NFYA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFYA Gene

Orthologs for NFYA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NFYA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFYA 34 35
  • 99.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFYA 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFYA 34 35
  • 95.1 (n)
oppossum
(Monodelphis domestica)
Mammalia NFYA 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFYA 34 35
  • 93.65 (n)
mouse
(Mus musculus)
Mammalia Nfya 34 16 35
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Nfya 34
  • 91.3 (n)
chicken
(Gallus gallus)
Aves NFYA 34 35
  • 82.6 (n)
lizard
(Anolis carolinensis)
Reptilia NFYA 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfya 34
  • 78.2 (n)
MGC76011 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.418 34
zebrafish
(Danio rerio)
Actinopterygii nfya 34 35
  • 79 (a)
nfyal 34 35
  • 75 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nf-YA 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nfya-2 35
  • 21 (a)
OneToMany
nfya-1 35
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAP2 35 37
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for NFYA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFYA Gene

ENSEMBL:
Gene Tree for NFYA (if available)
TreeFam:
Gene Tree for NFYA (if available)

Paralogs for NFYA Gene

No data available for Paralogs for NFYA Gene

Variants for NFYA Gene

Sequence variations from dbSNP and Humsavar for NFYA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080924 -- 41,091,430(+) GGATC(A/G)GTGAG intron-variant
rs1042256 -- 41,097,818(+) CTAGA(A/C/T)AGCAT upstream-variant-2KB, utr-variant-3-prime
rs10571989 -- 41,077,544(+) AATGT(-/ATTGT)GTATT intron-variant
rs1059008 -- 41,075,985(+) CTGTA(G/T)GATGA intron-variant
rs1064742 -- 41,071,178(-) GCTGT(C/T)CTCTT upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NFYA Gene

Variant ID Type Subtype PubMed ID
nsv602970 CNV gain 21841781
nsv1117437 CNV tandem duplication 24896259

Variation tolerance for NFYA Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFYA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFYA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFYA Gene

Disorders for NFYA Gene

Relevant External Links for NFYA

Human Genome Epidemiology (HuGE) Navigator
NFYA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFYA

No disorders were found for NFYA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFYA Gene

Publications for NFYA Gene

  1. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PMID: 19302979) Lim K. … Chang H.I. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  2. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PMID: 12659632) Yamada K. … Miyamoto K. (Biochem. J. 2003) 3 4 22 64
  3. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PMID: 23332751) Nardini M. … Mantovani R. (Cell 2013) 3 4 64
  4. Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. (PMID: 16959611) Di Agostino S. … Piaggio G. (Cancer Cell 2006) 3 22 64
  5. Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment. (PMID: 14688259) Lee M.R. … You H.J. (J. Biol. Chem. 2004) 3 22 64

Products for NFYA Gene

Sources for NFYA Gene

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