Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NFYA Gene

protein-coding   GIFtS: 61
GCID: GC06P041040

Nuclear Transcription Factor Y, Alpha

  Search for NFYA
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Transcription Factor Y, Alpha1 2     HAP22
Nuclear Transcription Factor Y Subunit A2 3     CAAT-Box DNA Binding Protein Subunit A2
NF-YA2 3     CCAAT-Binding Transcription Factor Subunit B2
CAAT Box DNA-Binding Protein Subunit A2 3     HAP2 CCAAT-Binding Protein2
CBF-A2     Nuclear Transcription Factor Y Subunit Alpha2
CBF-B2     Transcription Factor NF-Y, A Subunit2

External Ids:    HGNC: 78041   Entrez Gene: 48002   Ensembl: ENSG000000011677   OMIM: 1899035   UniProtKB: P235113   

Export aliases for NFYA gene to outside databases

Previous GC identifers: GC06P041042 GC06P041087 GC06P041148 GC06P040758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NFYA Gene:
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription
factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a
tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and
affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the
regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product,
either by protein degradation or control of translation. Further regulation is represented by alternative
splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NFYA Gene:
NFYA (nuclear transcription factor Y, alpha) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511
Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
for example in type 1 collagen, albumin and beta-actin genes

Gene Wiki entry for NFYA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFYA gene promoter:
         p53   CUTL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFYA promoter sequence
   Search Chromatin IP Primers for NFYA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFYA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.3

NFYA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFYA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041040:  view genomic region     (about GC identifiers)

Start:
41,040,684 bp from pter      End:
41,070,146 bp from pter
Size:
29,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511 (See protein sequence)
Recommended Name: Nuclear transcription factor Y subunit alpha  
Size: 347 amino acids; 36877 Da
Subunit: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC
must interact and dimerize for NF-YA association and DNA binding. Interacts with SP1; the interaction is
inhibited by glycosylation of SP1. Interacts with ZHX1. Interacts (via N-terminus) with ZHX2 (via homeobox
domain). Interacts with ZFX3
1 PDB 3D structure from and Proteopedia for NFYA:
4AWL (3D)    
Secondary accessions: Q8IXU0
Alternative splicing: 2 isoforms:  P23511-1   P23511-2   

Explore the universe of human proteins at neXtProt for NFYA: NX_P23511

Explore proteomics data for NFYA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys270
  • Modification sites at PhosphoSitePlus

  • See NFYA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002496.1  NP_068351.1  

    ENSEMBL proteins: 
     ENSP00000345702   ENSP00000229418  
    Reactome Protein details: P23511

    NFYA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NFYA
    OriGene Protein Over-expression Lysate for NFYA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NFYA
    GenScript Custom Purified and Recombinant Proteins Services for NFYA
    Novus Biologicals NFYA Proteins
    Novus Biologicals NFYA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NFYA 

    NFYA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NFYA
    OriGene Custom Antibody Services for NFYA
    Novus Biologicals NFYA Antibodies
    Abcam antibodies for NFYA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NFYA
    LSBio Antibodies in human, mouse, rat for NFYA

    NFYA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFYA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFYA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NFYA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001289 TF_CBFB
     IPR018362 CCAAT-binding_factor_CS

    Graphical View of Domain Structure for InterPro Entry P23511

    ProtoNet protein and cluster: P23511

    1 Blocks protein domain: IPB001289 CCAAT-binding transcription factor

    UniProtKB/Swiss-Prot: NFYA_HUMAN, P23511
    Similarity: Belongs to the NFYA/HAP2 subunit family
    Similarity: Contains 1 NFYA/HAP2-type DNA-binding domain


    Find genes that share domains with NFYA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFYA_HUMAN, P23511
    Function: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters,
    for example in type 1 collagen, albumin and beta-actin genes

         Genatlas biochemistry entry for NFYA:
    nuclear transcription factor NF-Y,A subunit,binding the CCAAT and the inverted CCAT box,Y box (ATGG) motifs in a
    variety of promoters,interacting with P/CAF

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15243141
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10571058
         
    Find genes that share ontologies with NFYA           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nfya):
     cellular  mortality/aging  no phenotypic analysis  other 

    Find genes that share phenotypes with NFYA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nfyatm1.1Mait for NFYA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFYA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFYA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFYA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFYA

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NFYA (see all 485):
    AASS,  ABI3,  ACADSB,  ACSL3,  ADNP2,  ADORA2B,  ADRA2B,  AGBL5,  AGPAT5,  AKAP9

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AGCCAATCGG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NFYA:
    hsa-mir-140-3p (MIRT021682), hsa-mir-221-3p (MIRT046947), hsa-mir-7-5p (MIRT025877), hsa-mir-192-5p (MIRT026722)

    Block miRNA regulation of human, mouse, rat NFYA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFYA (see all 103):
    hsa-miR-549 hsa-miR-140-5p hsa-miR-520f hsa-miR-520e hsa-miR-4254 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNFYA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFYA
    Predesigned siRNA for gene silencing in human, mouse, rat NFYA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFYA

    Clone
    Products:
         
    OriGene clones in human, mouse for NFYA (see all 12)
    OriGene ORF clones in mouse, rat for NFYA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFYA (NM_002505)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFYA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFYA
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFYA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NFYA_HUMAN, P23511: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15243141
    GO:0005654nucleoplasm TAS--
    GO:0016602CCAAT-binding factor complex IDA15243141

    Find genes that share ontologies with NFYA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NFYA About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    SREBP signalling0.31
    Activation of Gene Expression by SREBP (SREBF)0.75
    2Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    3Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by ATF6-alpha0.00
    Activation of Chaperones by ATF6-alpha0.00
    4PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with NFYA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NFYA
        Transcription Ligand-dependent activation of the ESR1/SP pathway

    Selected BioSystems Pathways for NFYA (see all 6)
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    SREBP signalling
    TGF-beta Receptor Signaling Pathway
    Direct p53 effectors

    4 Reactome Pathways for NFYA
        PPARA activates gene expression
    ATF6-alpha activates chaperone genes
    Activation of gene expression by SREBF (SREBP)
    ATF4 activates genes


    2 Kegg Pathways  (Kegg details for NFYA):
        Antigen processing and presentation
    Tuberculosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NFYA
    Interactions:

        GeneGlobe Interaction Network for NFYA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFYA (P235111, 2, 3 ENSP000003457024) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-389739,EBI-743771 MINT-68389 I2D: score=5 STRING: ENSP00000083182
    NFYBP252081, 3, ENSP000002400554EBI-389739,EBI-389728 I2D: score=4 STRING: ENSP00000240055
    NFYCQ139521, 3, ENSP000003966204EBI-389739,EBI-389755 I2D: score=4 STRING: ENSP00000396620
    TP53P046371, 3, ENSP000002693054EBI-389739,EBI-366083 I2D: score=4 STRING: ENSP00000269305
    SRSF1Q079551, 3, ENSP000002589624EBI-389739,EBI-398920 I2D: score=3 STRING: ENSP00000258962
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IDA15243141
    GO:0006366transcription from RNA polymerase II promoter TAS2000400
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0045893positive regulation of transcription, DNA-templated ----

    Find genes that share ontologies with NFYA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFYA

    4 Novoseek inferred chemical compound relationships for NFYA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 42.9 3 14688259 (2)
    serine 11 6 7814413 (4), 12427542 (1), 19302979 (1)
    glutamine 4.06 4 7814413 (4)
    retinoic acid 2.93 1 16223781 (1)



    Find genes that share compounds with NFYA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NFYA gene (2 alternative transcripts): 
    NM_002505.4  NM_021705.3  

    Unigene Cluster for NFYA:

    Nuclear transcription factor Y, alpha
    Hs.10441  [show with all ESTs]
    Unigene Representative Sequence: NM_002505
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341376(uc003opo.3 uc003opp.3 uc003opq.3) ENST00000353205

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFYA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFYA (see all 103):
    hsa-miR-549 hsa-miR-140-5p hsa-miR-520f hsa-miR-520e hsa-miR-4254 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNFYA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFYA
    Predesigned siRNA for gene silencing in human, mouse, rat NFYA
    Clone
    Products:
         
    OriGene clones in human, mouse for NFYA (see all 12)
    OriGene ORF clones in mouse, rat for NFYA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFYA (NM_002505)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFYA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFYA
    OriGene qSTAR qPCR primer pairs in human, mouse for NFYA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFYA
      QuantiTect SYBR Green Assays in human, mouse, rat NFYA
      QuantiFast Probe-based Assays in human, mouse, rat NFYA

    Additional mRNA sequence: 

    AJ420494.1 AK002098.1 AK025201.1 AL137443.1 BC026923.1 BC039244.1 GQ167198.1 M59079.1 
    X59711.1 

    8 DOTS entries:

    DT.308635  DT.100814884  DT.111705  DT.310783  DT.100814885  DT.91753183  DT.92423714  DT.121305348 

    Selected AceView cDNA sequences (see all 196):

    NM_002505 BG232065 CK823214 BI915526 BM893531 AA678780 BE675084 BM966743 
    BC026923 BX109895 CB046263 Z45635 BM674400 AI478773 BU623017 AI376542 
    AA779915 AA485283 AA425472 BM975747 AV728234 BU624343 BU154258 AI313501 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NFYA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:              -                                                                                 
    SP2:                          -                                                                     
    SP3:              -           -                                                                     
    SP4:                                                        -                                       
    SP5:              -                 -     -     -                                                   


    ECgene alternative splicing isoforms for NFYA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NFYA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTGTCGA
    NFYA Expression
    About this image


    NFYA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    NFYA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFYA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10441
        Custom PCR Arrays for NFYA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFYA
    OriGene qSTAR qPCR primer pairs in human, mouse for NFYA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFYA
    QuantiTect SYBR Green Assays in human, mouse, rat NFYA
    QuantiFast Probe-based Assays in human, mouse, rat NFYA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFYA gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfya1 , 5 nuclear transcription factor-Y alpha1, 5 91.45(n)1
    99.71(a)1
      17 (23.99 cM)5
    180441  NM_001110832.11  NP_001104302.11 
     483868855 
    chicken
    (Gallus gallus)
    Aves NFYA1 nuclear transcription factor Y, alpha 82.6(n)
    94.16(a)
      419917  NM_001006325.1  NP_001006325.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFYA6
    nuclear transcription factor Y, alpha
    97(a)
    1 ↔ 1
    4(123388562-123398075)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4182 Xenopus laevis nuclear Y/CCAAT-box binding factor A more 78.85(n)    AF041203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nfya2 nuclear transcription factor Y, alpha 75.12(n)   83915  57052282 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nf-YA6
    Nuclear factor Y-box A
    27(a)
    1 ↔ 1
    3L(9433156-9435367)
    worm
    (Caenorhabditis elegans)
    Secernentea nfya-26
    nfya-16
    Protein NFYA-1 (nfya-1) mRNA, complete cds
    21(a)
    15(a)
    many → 1
    many → 1
    I(11224836-11233337) WBGene00043056
    X(11944358-11946834) WBGene00011614
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAP2(YGL237C)4 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p more   --   7(53528-52731) 852614  NP_011277.1 
    corn
    (Zea mays)
    Liliopsida CD433238.12   -- 75.09(n)    CD433238.1 


    ENSEMBL Gene Tree for NFYA (if available)
    TreeFam Gene Tree for NFYA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NFYA (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs786168721,2
    F--41042258(+) TGACTG/CGCCTT 2 -- int11Minor allele frequency- C:0.03NA 120
    rs1460749611,2
    C--41042391(+) GTAGTA/TGTGAT 2 -- int10--------
    rs1388198341,2
    --41042550(+) TGTTTA/TTGGGT 2 -- int10--------
    rs22681881,2
    C,F,A,H--41042590(-) TCTTCA/CTCCCC 2 -- int122Minor allele frequency- C:0.36EA NS NA WA CSA 4200
    rs1156463271,2
    --41042644(+) AATCAC/TCTAGT 2 -- int10--------
    rs1925566081,2
    --41042924(+) TGGAAC/TGTTTT 2 -- int10--------
    rs22681871,2
    C,F,A--41042993(-) AGCTAC/TGATTG 2 -- int17Minor allele frequency- T:0.36NA WA CSA EA 366
    rs760041171,2
    C--41043040(+) CTTCTC/TGTTCT 2 -- int10--------
    rs1847394221,2
    --41043123(+) AAAAAC/TAGGTA 2 -- int10--------
    rs1161495971,2
    F--41043148(+) CAAAAT/ACACTA 2 -- int11Minor allele frequency- A:0.04NA 120

    HapMap Linkage Disequilibrium report for NFYA (41040684 - 41070146 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NFYA: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFYA
    DNA2.0 Custom Variant and Variant Library Synthesis for NFYA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 189903    OMIM disorders: --


    Find genes that share disorders with NFYA           About GenesLikeMe

    1 Novoseek inferred disease relationship for NFYA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 19265534 (1)

    Human Genome Epidemiology (HuGE) Navigator: NFYA (2 documents)

    Export disorders for NFYA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NFYA gene, integrated from 10 sources (see all 141):
    (articles sorted by number of sources associating them with NFYA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PubMed id 12659632)1, 2, 9 Yamada K.... Miyamoto K. (Biochem. J. 2003)
    2. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PubMed id 19302979)1, 2, 9 Lim K. and Chang H.I. (Biochem. Biophys. Res. Commun. 2009)
    3. Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. (PubMed id 23332751)1, 2 Nardini M.... Mantovani R. (Cell 2013)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)1, 2 Kawata H.... Miyamoto K. (Biochem. J. 2003)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Identification of proteins that interact with NF-YA. (PubMed id 10571058)1, 2 Yamada K.... Granner D.K. (FEBS Lett. 1999)
    8. Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. (PubMed id 10441475)1, 2 Yamada K.... Granner D.K. (Biochem. Biophys. Res. Commun. 1999)
    9. Role of the CCAAT-binding protein CBF/NF-Y in transcription. (PubMed id 9612081)1, 3 Maity S.N. and de Crombrugghe B. (Trends Biochem. Sci. 1998)
    10. Evolutionary variation of the CCAAT-binding transcription factor NF- Y. (PubMed id 1549471)1, 2 Li X.-Y.... Mathis D. (Nucleic Acids Res. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4800 HGNC: 7804 AceView: NFYA Ensembl:ENSG00000001167 euGenes: HUgn4800
    ECgene: NFYA Kegg: 4800 H-InvDB: NFYA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NFYA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NFYA gene:
    Search GeneIP for patents involving NFYA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NFYA   OriGene RNAi products in human, mouse, rat for NFYA  
     OriGene qPCR primer pairs and template standards for NFYA   OriGene Protein Over-expression Lysate for NFYA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NFYA  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFYA   OriGene Purified Protein for NFYA  
     OriGene ORF clones in mouse, rat for NFYA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFYA   OriGene Custom Protein Services for NFYA  

     
     
     Block miRNA regulation of human, mouse, rat NFYA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NFYA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFYA Predesigned siRNA for gene silencing in human, mouse, rat NFYA
     QuantiFast Probe-based Assays in human, mouse, rat NFYA QuantiTect SYBR Green Assays in human, mouse, rat NFYA
     Custom PCR Arrays for NFYA Search Chromatin IP Primers for NFYA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFYA  GeneGlobe Interaction Network for NFYA
     Regulatory tfbs in NFYA promoter
     GenScript Custom Purified and Recombinant Proteins Services for NFYA GenScript cDNA clones with any tag delivered in your preferred vector for NFYA
     GenScript Custom Assay Services for NFYA GenScript Custom overexpressing Cell Line Services for NFYA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NFYA
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NFYA antibodies
     NFYA proteins
     NFYA lysates
     Antibodies for NFYA
     See all of Abcam's Antibodies, Kits and Proteins for NFYA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for NFYA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFYA
     SwitchGear 3'UTR luciferase reporter plasmids for NFYA
     SwitchGear Promoter luciferase reporter plasmids for NFYA
     ThermoFisher Antibody for NFYA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFYA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFYA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFYA
     LSBio Antibodies in human, mouse, rat for NFYA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NFYA
      Search eBioscience for proteins for NFYA
      Search eBioscience for elisas for NFYA
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFYA gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4