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Aliases for NFXL1 Gene

Aliases for NFXL1 Gene

  • Nuclear Transcription Factor, X-Box Binding-Like 1 2 3
  • Ovarian Zinc Finger Protein 2 3 4
  • HOZFP 3 4
  • OZFP 3 4
  • Cytoplasm-Distribution Zinc Finger Protein 3
  • Up-Regulated In Colon Cancer 5 3
  • CDZFP 3
  • URCC5 3

External Ids for NFXL1 Gene

Previous GeneCards Identifiers for NFXL1 Gene

  • GC00U991226
  • GC04M047691
  • GC04M047544
  • GC04M047168

Summaries for NFXL1 Gene

GeneCards Summary for NFXL1 Gene

NFXL1 (Nuclear Transcription Factor, X-Box Binding-Like 1) is a Protein Coding gene. Diseases associated with NFXL1 include speech and communication disorders. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NFX1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFXL1 Gene

Genomics for NFXL1 Gene

Regulatory Elements for NFXL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFXL1 Gene

Chromosome:
4
Start:
47,847,233 bp from pter
End:
47,914,667 bp from pter
Size:
67,435 bases
Orientation:
Minus strand

Genomic View for NFXL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFXL1 Gene

Proteins for NFXL1 Gene

  • Protein details for NFXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNB6-NFXL1_HUMAN
    Recommended name:
    NF-X1-type zinc finger protein NFXL1
    Protein Accession:
    Q6ZNB6
    Secondary Accessions:
    • B1Q2K1
    • Q86VG1
    • Q8WVH1

    Protein attributes for NFXL1 Gene

    Size:
    911 amino acids
    Molecular mass:
    101339 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18459.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NFXL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFXL1 Gene

Proteomics data for NFXL1 Gene at MOPED

Post-translational modifications for NFXL1 Gene

  • Ubiquitination at Lys 238, Lys 402, Lys 534, Lys 588, Lys 604, Lys 661, Lys 693, Lys 759, and Lys 766
  • Modification sites at PhosphoSitePlus

Other Protein References for NFXL1 Gene

No data available for DME Specific Peptides for NFXL1 Gene

Domains & Families for NFXL1 Gene

Protein Domains for NFXL1 Gene

Suggested Antigen Peptide Sequences for NFXL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNB6

UniProtKB/Swiss-Prot:

NFXL1_HUMAN :
  • Belongs to the NFX1 family.
  • Contains 10 NF-X1-type zinc fingers.
Family:
  • Belongs to the NFX1 family.
Similarity:
  • Contains 10 NF-X1-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with NFXL1: view

No data available for Gene Families for NFXL1 Gene

Function for NFXL1 Gene

Gene Ontology (GO) - Molecular Function for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with NFXL1: view

Phenotypes for NFXL1 Gene

genes like me logo Genes that share phenotypes with NFXL1: view

Animal Model Products

miRNA for NFXL1 Gene

miRTarBase miRNAs that target NFXL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NFXL1 Gene

Localization for NFXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFXL1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFXL1 Gene COMPARTMENTS Subcellular localization image for NFXL1 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NFXL1: view

Pathways & Interactions for NFXL1 Gene

SuperPathways for NFXL1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NFXL1 Gene

Gene Ontology (GO) - Biological Process for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with NFXL1: view

No data available for Pathways by source and SIGNOR curated interactions for NFXL1 Gene

Drugs & Compounds for NFXL1 Gene

No Compound Related Data Available

Transcripts for NFXL1 Gene

Unigene Clusters for NFXL1 Gene

Nuclear transcription factor, X-box binding-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFXL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFXL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5: -
SP6:

Relevant External Links for NFXL1 Gene

GeneLoc Exon Structure for
NFXL1
ECgene alternative splicing isoforms for
NFXL1

Expression for NFXL1 Gene

mRNA expression in normal human tissues for NFXL1 Gene

Protein differential expression in normal tissues from HIPED for NFXL1 Gene

This gene is overexpressed in Testis (17.8), Plasma (12.0), Placenta (11.3), and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFXL1 Gene



SOURCE GeneReport for Unigene cluster for NFXL1 Gene Hs.646325

genes like me logo Genes that share expression patterns with NFXL1: view

Protein tissue co-expression partners for NFXL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFXL1 Gene

Orthologs for NFXL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFXL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFXL1 35
  • 91.29 (n)
  • 92.97 (a)
NFXL1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFXL1 35
  • 90.83 (n)
  • 90.65 (a)
NFXL1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfxl1 35
  • 87.52 (n)
  • 89.79 (a)
Nfxl1 16
Nfxl1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFXL1 35
  • 99.41 (n)
  • 99.23 (a)
NFXL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfxl1 35
  • 86.57 (n)
  • 88.58 (a)
oppossum
(Monodelphis domestica)
Mammalia NFXL1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves NFXL1 35
  • 75.5 (n)
  • 76.9 (a)
NFXL1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFXL1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfxl1 35
  • 70.96 (n)
  • 73.3 (a)
zebrafish
(Danio rerio)
Actinopterygii nfxl1 35
  • 61.71 (n)
  • 63.65 (a)
nfxl1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005362 35
  • 47.47 (n)
  • 43.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15011 35
  • 49.79 (n)
  • 44.19 (a)
CG15011 36
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP1 36
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATNFXL2 35
  • 49.63 (n)
  • 43.12 (a)
rice
(Oryza sativa)
Liliopsida Os01g0158900 35
  • 48.68 (n)
  • 41.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for NFXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFXL1 Gene

ENSEMBL:
Gene Tree for NFXL1 (if available)
TreeFam:
Gene Tree for NFXL1 (if available)

Paralogs for NFXL1 Gene

Paralogs for NFXL1 Gene

(2) SIMAP similar genes for NFXL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFXL1: view

Variants for NFXL1 Gene

Sequence variations from dbSNP and Humsavar for NFXL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_030869 -

Structural Variations from Database of Genomic Variants (DGV) for NFXL1 Gene

Variant ID Type Subtype PubMed ID
nsv829924 CNV Gain 17160897
nsv4328 CNV Loss 18451855

Variation tolerance for NFXL1 Gene

Residual Variation Intolerance Score: 30.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.41; 96.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFXL1 Gene

HapMap Linkage Disequilibrium report
NFXL1
Human Gene Mutation Database (HGMD)
NFXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFXL1 Gene

Disorders for NFXL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NFXL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
speech and communication disorders
  • communication disorder
- elite association
Search NFXL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NFXL1

Genetic Association Database (GAD)
NFXL1
Human Genome Epidemiology (HuGE) Navigator
NFXL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFXL1
genes like me logo Genes that share disorders with NFXL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFXL1 Gene

Publications for NFXL1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  4. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for NFXL1 Gene

Sources for NFXL1 Gene

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