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Aliases for NFXL1 Gene

Aliases for NFXL1 Gene

  • Nuclear Transcription Factor, X-Box Binding Like 1 2 3 5
  • Ovarian Zinc Finger Protein 2 3 4
  • HOZFP 3 4
  • OZFP 3 4
  • Cytoplasm-Distribution Zinc Finger Protein 3
  • NF-X1-Type Zinc Finger Protein NFXL1 3
  • Up-Regulated In Colon Cancer 5 3
  • CDZFP 3
  • URCC5 3

External Ids for NFXL1 Gene

Previous GeneCards Identifiers for NFXL1 Gene

  • GC00U991226
  • GC04M047691
  • GC04M047544
  • GC04M047168

Summaries for NFXL1 Gene

GeneCards Summary for NFXL1 Gene

NFXL1 (Nuclear Transcription Factor, X-Box Binding Like 1) is a Protein Coding gene. Diseases associated with NFXL1 include Specific Language Impairment and Speech And Communication Disorders. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NFX1.

Additional gene information for NFXL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFXL1 Gene

Genomics for NFXL1 Gene

Regulatory Elements for NFXL1 Gene

Enhancers for NFXL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H047913 1.1 ENCODE 55.7 +0.5 455 2 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF143 SP3 MXD4 NFXL1 CNGA1 SLAIN2 NIPAL1 LOC101927157
GH04H047836 0.9 ENCODE 55.1 +77.5 77470 1 ELF3 PKNOX1 ARID4B RAD21 GLIS2 ZNF143 IKZF2 MIXL1 THAP11 ZNF654 NFXL1 CNGA1 CORIN LOC101927179
GH04H047838 0.9 Ensembl ENCODE 54.4 +75.4 75370 0 CTCF TRIM22 RAD21 IKZF1 EED ZNF143 SMC3 ATF7 RUNX3 NFXL1 CNGA1 CORIN GC04P047839
GH04H048014 1.5 Ensembl ENCODE dbSUPER 23.7 -104.5 -104490 8 FOXA2 ATF1 SIN3A DMAP1 YY1 GLIS2 FOS ATF7 ZNF202 SP3 CNGA1 NFXL1 NIPAL1 RNU6-838P GC04P048104
GH04H047824 0.9 VISTA ENCODE 36.2 +89.4 89425 1 IKZF1 IKZF2 NFXL1 NIPAL1 CNGA1 GC04P047826 GC04M047659
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFXL1 on UCSC Golden Path with GeneCards custom track

Promoters for NFXL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168076 367 2201 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF143 SP3

Genomic Location for NFXL1 Gene

Chromosome:
4
Start:
47,847,233 bp from pter
End:
47,914,667 bp from pter
Size:
67,435 bases
Orientation:
Minus strand

Genomic View for NFXL1 Gene

Genes around NFXL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFXL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFXL1 Gene

Proteins for NFXL1 Gene

  • Protein details for NFXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNB6-NFXL1_HUMAN
    Recommended name:
    NF-X1-type zinc finger protein NFXL1
    Protein Accession:
    Q6ZNB6
    Secondary Accessions:
    • B1Q2K1
    • Q86VG1
    • Q8WVH1

    Protein attributes for NFXL1 Gene

    Size:
    911 amino acids
    Molecular mass:
    101339 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18459.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NFXL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFXL1 Gene

Post-translational modifications for NFXL1 Gene

  • Ubiquitination at posLast=238238, Lys402, Lys534, Lys588, posLast=604604, posLast=661661, Lys693, posLast=759759, and Lys766
  • Modification sites at PhosphoSitePlus

Other Protein References for NFXL1 Gene

No data available for DME Specific Peptides for NFXL1 Gene

Domains & Families for NFXL1 Gene

Gene Families for NFXL1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NFXL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNB6

UniProtKB/Swiss-Prot:

NFXL1_HUMAN :
  • Belongs to the NFX1 family.
Family:
  • Belongs to the NFX1 family.
genes like me logo Genes that share domains with NFXL1: view

Function for NFXL1 Gene

Gene Ontology (GO) - Molecular Function for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NFXL1: view
genes like me logo Genes that share phenotypes with NFXL1: view

Animal Models for NFXL1 Gene

MGI Knock Outs for NFXL1:

Animal Model Products

CRISPR Products

miRNA for NFXL1 Gene

miRTarBase miRNAs that target NFXL1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFXL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFXL1 Gene

Localization for NFXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFXL1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFXL1 gene
Compartment Confidence
nucleus 5
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NFXL1: view

Pathways & Interactions for NFXL1 Gene

SuperPathways for NFXL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with NFXL1: view

No data available for Pathways by source and SIGNOR curated interactions for NFXL1 Gene

Drugs & Compounds for NFXL1 Gene

No Compound Related Data Available

Transcripts for NFXL1 Gene

Unigene Clusters for NFXL1 Gene

Nuclear transcription factor, X-box binding-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFXL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NFXL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5: -
SP6:

Relevant External Links for NFXL1 Gene

GeneLoc Exon Structure for
NFXL1
ECgene alternative splicing isoforms for
NFXL1

Expression for NFXL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFXL1 Gene

Protein differential expression in normal tissues from HIPED for NFXL1 Gene

This gene is overexpressed in Testis (17.8), Plasma (12.0), Placenta (11.3), and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFXL1 Gene



Protein tissue co-expression partners for NFXL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFXL1 Gene:

NFXL1

SOURCE GeneReport for Unigene cluster for NFXL1 Gene:

Hs.646325

Evidence on tissue expression from TISSUES for NFXL1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NFXL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFXL1 Gene

Orthologs for NFXL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFXL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFXL1 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia NFXL1 33 34
  • 91.29 (n)
dog
(Canis familiaris)
Mammalia NFXL1 33 34
  • 90.83 (n)
mouse
(Mus musculus)
Mammalia Nfxl1 33 16 34
  • 87.52 (n)
rat
(Rattus norvegicus)
Mammalia Nfxl1 33
  • 86.57 (n)
oppossum
(Monodelphis domestica)
Mammalia NFXL1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves NFXL1 33 34
  • 75.5 (n)
lizard
(Anolis carolinensis)
Reptilia NFXL1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfxl1 33
  • 70.96 (n)
zebrafish
(Danio rerio)
Actinopterygii nfxl1 33 34
  • 61.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15011 33 34
  • 49.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005362 33
  • 47.47 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP1 34
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATNFXL2 33
  • 49.63 (n)
rice
(Oryza sativa)
Liliopsida Os01g0158900 33
  • 48.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
Species where no ortholog for NFXL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFXL1 Gene

ENSEMBL:
Gene Tree for NFXL1 (if available)
TreeFam:
Gene Tree for NFXL1 (if available)

Paralogs for NFXL1 Gene

Paralogs for NFXL1 Gene

(2) SIMAP similar genes for NFXL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFXL1: view

Variants for NFXL1 Gene

Sequence variations from dbSNP and Humsavar for NFXL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000055505 -- 47,901,701(+) AATTT(-/A)AAAGT intron-variant
rs1000071439 -- 47,878,840(+) AGTAA(C/T)GAATG intron-variant
rs1000088810 -- 47,866,792(+) GTTTA(C/T)GCTGA intron-variant
rs1000130155 -- 47,914,757(+) GGCCC(C/G/T)AACAG intron-variant, upstream-variant-2KB
rs1000242218 -- 47,850,611(+) AATCC(A/C/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFXL1 Gene

Variant ID Type Subtype PubMed ID
dgv5202n100 CNV gain 25217958
nsv4328 CNV deletion 18451855
nsv477067 CNV novel sequence insertion 20440878
nsv594118 CNV loss 21841781
nsv829924 CNV gain 17160897

Variation tolerance for NFXL1 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.41; 96.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFXL1 Gene

Human Gene Mutation Database (HGMD)
NFXL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFXL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFXL1 Gene

Disorders for NFXL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NFXL1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
specific language impairment
speech and communication disorders
  • communication disorder
- elite association - COSMIC cancer census association via MalaCards
Search NFXL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NFXL1

Genetic Association Database (GAD)
NFXL1
Human Genome Epidemiology (HuGE) Navigator
NFXL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFXL1
genes like me logo Genes that share disorders with NFXL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFXL1 Gene

Publications for NFXL1 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for NFXL1 Gene

Sources for NFXL1 Gene

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