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Aliases for NFXL1 Gene

Aliases for NFXL1 Gene

  • Nuclear Transcription Factor, X-Box Binding Like 1 2 3
  • Ovarian Zinc Finger Protein 2 3 4
  • Nuclear Transcription Factor, X-Box Binding-Like 1 3 5
  • HOZFP 3 4
  • OZFP 3 4
  • Cytoplasm-Distribution Zinc Finger Protein 3
  • Up-Regulated In Colon Cancer 5 3
  • CDZFP 3
  • URCC5 3

External Ids for NFXL1 Gene

Previous GeneCards Identifiers for NFXL1 Gene

  • GC00U991226
  • GC04M047691
  • GC04M047544
  • GC04M047168

Summaries for NFXL1 Gene

GeneCards Summary for NFXL1 Gene

NFXL1 (Nuclear Transcription Factor, X-Box Binding Like 1) is a Protein Coding gene. Diseases associated with NFXL1 include Speech And Communication Disorders and Specific Language Impairment. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NFX1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFXL1 Gene

Genomics for NFXL1 Gene

Regulatory Elements for NFXL1 Gene

Enhancers for NFXL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NFXL1 on UCSC Golden Path with GeneCards custom track

Promoters for NFXL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NFXL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NFXL1 Gene

47,847,233 bp from pter
47,914,667 bp from pter
67,435 bases
Minus strand

Genomic View for NFXL1 Gene

Genes around NFXL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFXL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFXL1 Gene

Proteins for NFXL1 Gene

  • Protein details for NFXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NF-X1-type zinc finger protein NFXL1
    Protein Accession:
    Secondary Accessions:
    • B1Q2K1
    • Q86VG1
    • Q8WVH1

    Protein attributes for NFXL1 Gene

    911 amino acids
    Molecular mass:
    101339 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18459.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NFXL1 Gene


neXtProt entry for NFXL1 Gene

Proteomics data for NFXL1 Gene at MOPED

Post-translational modifications for NFXL1 Gene

  • Ubiquitination at Lys 238, Lys 402, Lys 534, Lys 588, Lys 604, Lys 661, Lys 693, Lys 759, and Lys 766
  • Modification sites at PhosphoSitePlus

Other Protein References for NFXL1 Gene

No data available for DME Specific Peptides for NFXL1 Gene

Domains & Families for NFXL1 Gene

Protein Domains for NFXL1 Gene

Suggested Antigen Peptide Sequences for NFXL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NFX1 family.
  • Contains 10 NF-X1-type zinc fingers.
  • Belongs to the NFX1 family.
  • Contains 10 NF-X1-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with NFXL1: view

No data available for Gene Families for NFXL1 Gene

Function for NFXL1 Gene

Gene Ontology (GO) - Molecular Function for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with NFXL1: view
genes like me logo Genes that share phenotypes with NFXL1: view

Animal Models for NFXL1 Gene

MGI Knock Outs for NFXL1:

Animal Model Products

miRNA for NFXL1 Gene

miRTarBase miRNAs that target NFXL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFXL1 Gene

Localization for NFXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFXL1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NFXL1 Gene COMPARTMENTS Subcellular localization image for NFXL1 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NFXL1: view

Pathways & Interactions for NFXL1 Gene

SuperPathways for NFXL1 Gene

No Data Available

Interacting Proteins for NFXL1 Gene

Gene Ontology (GO) - Biological Process for NFXL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NFXL1 Gene

Drugs & Compounds for NFXL1 Gene

No Compound Related Data Available

Transcripts for NFXL1 Gene

Unigene Clusters for NFXL1 Gene

Nuclear transcription factor, X-box binding-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFXL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP4: - -
SP5: -

Relevant External Links for NFXL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFXL1 Gene

mRNA expression in normal human tissues for NFXL1 Gene

Protein differential expression in normal tissues from HIPED for NFXL1 Gene

This gene is overexpressed in Testis (17.8), Plasma (12.0), Placenta (11.3), and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFXL1 Gene

SOURCE GeneReport for Unigene cluster for NFXL1 Gene Hs.646325

genes like me logo Genes that share expression patterns with NFXL1: view

Protein tissue co-expression partners for NFXL1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFXL1 Gene

Orthologs for NFXL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFXL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NFXL1 35
  • 91.29 (n)
  • 92.97 (a)
NFXL1 36
  • 92 (a)
(Canis familiaris)
Mammalia NFXL1 35
  • 90.83 (n)
  • 90.65 (a)
NFXL1 36
  • 90 (a)
(Mus musculus)
Mammalia Nfxl1 35
  • 87.52 (n)
  • 89.79 (a)
Nfxl1 16
Nfxl1 36
  • 87 (a)
(Pan troglodytes)
Mammalia NFXL1 35
  • 99.41 (n)
  • 99.23 (a)
NFXL1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nfxl1 35
  • 86.57 (n)
  • 88.58 (a)
(Monodelphis domestica)
Mammalia NFXL1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves NFXL1 35
  • 75.5 (n)
  • 76.9 (a)
NFXL1 36
  • 74 (a)
(Anolis carolinensis)
Reptilia NFXL1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nfxl1 35
  • 70.96 (n)
  • 73.3 (a)
(Danio rerio)
Actinopterygii nfxl1 35
  • 61.71 (n)
  • 63.65 (a)
nfxl1 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005362 35
  • 47.47 (n)
  • 43.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15011 35
  • 49.79 (n)
  • 44.19 (a)
CG15011 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP1 36
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATNFXL2 35
  • 49.63 (n)
  • 43.12 (a)
(Oryza sativa)
Liliopsida Os01g0158900 35
  • 48.68 (n)
  • 41.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for NFXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFXL1 Gene

Gene Tree for NFXL1 (if available)
Gene Tree for NFXL1 (if available)

Paralogs for NFXL1 Gene

Paralogs for NFXL1 Gene

(2) SIMAP similar genes for NFXL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFXL1: view

Variants for NFXL1 Gene

Sequence variations from dbSNP and Humsavar for NFXL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs12651301 - 47,899,459(+) GCCAC(A/G)GATCT nc-transcript-variant, reference, missense
rs1371730 -- 47,906,587(-) TTTTT(A/T)AAAAA intron-variant
rs1545200 -- 47,903,800(-) GGGCT(A/G)TGTAG intron-variant
rs1822030 -- 47,905,507(-) CTTGA(C/T)AGCTC intron-variant
rs2119204 -- 47,903,141(-) AGTTT(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFXL1 Gene

Variant ID Type Subtype PubMed ID
nsv829924 CNV Gain 17160897
nsv4328 CNV Loss 18451855

Variation tolerance for NFXL1 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.41; 96.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFXL1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFXL1 Gene

Disorders for NFXL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NFXL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
speech and communication disorders
  • communication disorder
specific language impairment
- elite association - COSMIC cancer census association via MalaCards
Search NFXL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NFXL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NFXL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFXL1 Gene

Publications for NFXL1 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Exome sequencing in an admixed isolated population indicates NFXL1 variants confer a risk for specific language impairment. (PMID: 25781923) Villanueva P. … Newbury D.F. (PLoS Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for NFXL1 Gene

Sources for NFXL1 Gene