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NFXL1 Gene

protein-coding   GIFtS: 50
GCID: GC04M047849

Nuclear Transcription Factor, X-Box Binding-Like 1

  See NFXL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Transcription Factor, X-Box Binding-Like 11 2     URCC52
Ovarian Zinc Finger Protein1 2 3     Cytoplasm-Distribution Zinc Finger Protein2
OZFP2 3     NF-X1-Type Zinc Finger Protein NFXL12
CDZFP2     Up-Regulated In Colon Cancer 52
HOZFP2     hOZFP3

External Ids:    HGNC: 187261   Entrez Gene: 1525182   Ensembl: ENSG000001704487   UniProtKB: Q6ZNB63   

Export aliases for NFXL1 gene to outside databases

Previous GC identifers: GC00U991226 GC04M047691 GC04M047544 GC04M047168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NFXL1 Gene:
NFXL1 (nuclear transcription factor, X-box binding-like 1) is a protein-coding gene. Diseases associated with NFXL1 include colon cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFX1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006238.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFXL1 gene promoter:
         Max1   USF1   p53   MyoD   Lmo2   IRF-2   E2F-1   E2F   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFXL1 promoter sequence
   Search Chromatin IP Primers for NFXL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFXL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p12

NFXL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFXL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M047849:  view genomic region     (about GC identifiers)

Start:
47,849,257 bp from pter      End:
47,916,653 bp from pter
Size:
67,397 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NFXL1_HUMAN, Q6ZNB6 (See protein sequence)
Recommended Name: NF-X1-type zinc finger protein NFXL1  
Size: 911 amino acids; 101339 Da
Sequence caution: Sequence=BAD18459.1; Type=Erroneous initiation;
Secondary accessions: B1Q2K1 Q86VG1 Q8WVH1
Alternative splicing: 2 isoforms:  Q6ZNB6-1   Q6ZNB6-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for NFXL1: NX_Q6ZNB6

Explore proteomics data for NFXL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys238, Lys402, Lys534, Lys588, Lys604, Lys661, Lys693, Lys759, Lys766
  • Modification sites at PhosphoSitePlus

  • See NFXL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_694540.3  NP_001265552.1  NP_001265553.1  

    ENSEMBL proteins: 
     ENSP00000370949   ENSP00000425812   ENSP00000422037   ENSP00000333113  

    NFXL1 Human Recombinant Protein Products:

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    Novus Biologicals NFXL1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NFXL1

     
    Search eBioscience for Proteins for NFXL1 

    NFXL1 Antibody Products:

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    NFXL1 Assay Products:

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    Search eBioscience for ELISAs for NFXL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000967 Znf_NFX1
     IPR001841 Znf_RING
     IPR019786 Zinc_finger_PHD-type_CS

    Graphical View of Domain Structure for InterPro Entry Q6ZNB6

    ProtoNet protein and cluster: Q6ZNB6

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003267 Small proline-rich protein signature


    UniProtKB/Swiss-Prot: NFXL1_HUMAN, Q6ZNB6
    Similarity: Belongs to the NFX1 family
    Similarity: Contains 10 NF-X1-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with NFXL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with NFXL1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nfxl1):
     growth/size/body  limbs/digits/tail  skeleton 

    Find genes that share phenotypes with NFXL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFXL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFXL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFXL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFXL1

    miRNA
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    miRTarBase miRNAs that target NFXL1:
    hsa-mir-500a-5p (MIRT038003)

    Block miRNA regulation of human, mouse, rat NFXL1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NFXL1:
    hsa-miR-577 hsa-miR-548p hsa-miR-135b hsa-miR-24 hsa-miR-3145-3p hsa-miR-570 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidNFXL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFXL1
    Predesigned siRNA for gene silencing in human, mouse, rat NFXL1

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    GenScript: all cDNA clones in your preferred vector: NFXL1 (NM_152995)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFXL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFXL1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NFXL1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFXL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFXL1_HUMAN, Q6ZNB6: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NFXL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NFXL1: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NFXL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for NFXL1 (Q6ZNB63 ENSP000003709494) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SARM1Q6SZW13I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    FKBP1AENSP000003711384STRING: ENSP00000371138
    FKBP1BENSP000003703734STRING: ENSP00000370373
    FKBP1CENSP000003596934STRING: ENSP00000359693
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with NFXL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFXL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NFXL1 gene (3 alternative transcripts): 
    NM_152995.5  NM_001278623.1  NM_001278624.1  

    Unigene Cluster for NFXL1:

    Nuclear transcription factor, X-box binding-like 1
    Hs.646325  [show with all ESTs]
    Unigene Representative Sequence: AB181916
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502448(uc003gxo.3) ENST00000381538(uc003gxp.3) ENST00000464756(uc003gxq.4 uc010igi.3)
    ENST00000507489(uc010igh.3) ENST00000507131 ENST00000508115 ENST00000511452
    ENST00000329043
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFXL1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NFXL1:
    hsa-miR-577 hsa-miR-548p hsa-miR-135b hsa-miR-24 hsa-miR-3145-3p hsa-miR-570 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidNFXL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NFXL1
    Predesigned siRNA for gene silencing in human, mouse, rat NFXL1
    Clone
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    OriGene clones in human, mouse for NFXL1 (see all 7)
    OriGene ORF clones in mouse, rat for NFXL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFXL1 (NM_152995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFXL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFXL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFXL1
    OriGene qSTAR qPCR primer pairs in human, mouse for NFXL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFXL1
      QuantiTect SYBR Green Assays in human, mouse, rat NFXL1
      QuantiFast Probe-based Assays in human, mouse, rat NFXL1

    Additional mRNA sequence: 

    AB085695.1 AB181916.1 AK131285.1 AK302440.1 AY134856.1 BC018019.1 BC040151.1 

    7 DOTS entries:

    DT.92049460  DT.101975377  DT.102839487  DT.426371  DT.99982258  DT.102839486  DT.121240869 

    Selected AceView cDNA sequences (see all 102):

    AI420051 AL697900 BM466645 BC040151 AI700455 BF108827 BF971191 AA908176 
    AK131285 AA046682 BG773458 AF133845 AI354875 BM468006 NM_006587 AI890823 
    BM781738 BU620685 BF221651 AI625201 AA906367 BU568855 AI739441 BX101512 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFXL1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:              -     -                                                                                                         
    SP5:                    -                                                                                                         


    ECgene alternative splicing isoforms for NFXL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NFXL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCGTAAAA
    NFXL1 Expression
    About this image

    NFXL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFXL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646325
        Pathway & Disease-focused RT2 Profiler PCR Array including NFXL1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFXL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFXL1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfxl11 , 5 nuclear transcription factor, X-box binding-like 11, 5 87.52(n)1
    89.79(a)1
      5 (38.44 cM)5
    1009781  NM_133921.21  NP_598682.21 
     725133015 
    chicken
    (Gallus gallus)
    Aves NFXL11 nuclear transcription factor, X-box binding-like 1 75.5(n)
    76.9(a)
      100859761  XM_003641238.2  XP_003641286.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFXL16
    nuclear transcription factor, X-box binding-like 1...
    76(a)
    1 ↔ 1
    GL343293.1(517433-587868)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nfxl11 nuclear transcription factor, X-box binding-like 1 70.96(n)
    73.3(a)
      100126060  NM_001169135.1  NP_001162606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nfxl11 nuclear transcription factor, X-box binding-like 1 61.71(n)
    63.65(a)
      100333008  XM_002666544.3  XP_002666590.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG150111 CG15011 49.79(n)
    44.19(a)
      38518  NM_139622.1  NP_647879.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAP16
    Protein that binds to Fpr1p, conferring rapamycin ...
    20(a)
    1 → many
    XIV(588263-591160) YNL023C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATNFXL21 ATNFXL2 49.63(n)
    43.12(a)
      830450  NM_120648.5  NP_196185.3 
    rice
    (Oryza sativa)
    Liliopsida Os01g01589001 Os01g0158900 48.68(n)
    41.23(a)
      4324058  NM_001048615.1  NP_001042080.1 


    ENSEMBL Gene Tree for NFXL1 (if available)
    TreeFam Gene Tree for NFXL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFXL1 gene
    NFX12  
    2 SIMAP similar genes for NFXL1 using alignment to 2 protein entries:     NFXL1_HUMAN (see all proteins):
    HOZFP    URCC5

    Find genes that share paralogs with NFXL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFXL1 (see all 1312)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895403771,2
    --47848841(+) CAAACA/GCCGCA 1 -- ds50010--------
    rs1807138061,2
    --47848988(+) CAAGTC/TAATGG 1 -- ds50010--------
    rs1853334581,2
    --47848996(+) TGGGTA/GCAGCA 1 -- ds50010--------
    rs1900459191,2
    --47849179(+) TTTCAC/TACATT 1 -- ds50010--------
    rs1457669031,2
    --47849346(+) TTTGAC/TTTACT 1 -- ut310--------
    rs580263411,2
    C,F--47849359(+) TATTTC/TTCTAT 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs131036971,2
    C,F,H--47849391(+) ATTTTC/TAGCTG 1 -- ut31 ese312Minor allele frequency- T:0.01NS EA NA 1400
    rs1812494931,2
    --47849392(+) TTTTCA/GGCTGA 1 -- ut310--------
    rs1416010521,2
    --47849460(+) CCCTGC/TTGTCA 1 -- ut310--------
    rs1867123271,2
    --47849485(+) TAAATA/TCTCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NFXL1 (47849257 - 47916653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NFXL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4328CNV Loss18451855
    nsv829924CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFXL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NFXL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for NFXL1:    
    About MalaCards
    colon cancer

    1 disease from the University of Copenhagen DISEASES database for NFXL1:
    Mucoepidermoid carcinoma

    Find genes that share disorders with NFXL1           About GenesLikeMe

    Genetic Association Database (GAD): NFXL1
    Human Genome Epidemiology (HuGE) Navigator: NFXL1 (1 document)

    Export disorders for NFXL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFXL1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with NFXL1)
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    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 152518 HGNC: 18726 AceView: CORINandHOZFP Ensembl:ENSG00000170448 euGenes: HUgn152518
    ECgene: NFXL1 H-InvDB: NFXL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NFXL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFXL1 gene:
    Search GeneIP for patents involving NFXL1

    GeneCards and IP:
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