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Aliases for NFXL1 Gene

Aliases for NFXL1 Gene

  • Nuclear Transcription Factor, X-Box Binding-Like 1 2 3
  • Ovarian Zinc Finger Protein 2 3 4
  • HOZFP 3 4
  • OZFP 3 4
  • Cytoplasm-Distribution Zinc Finger Protein 3
  • NF-X1-Type Zinc Finger Protein NFXL1 3
  • Up-Regulated In Colon Cancer 5 3
  • CDZFP 3
  • URCC5 3

External Ids for NFXL1 Gene

Previous GeneCards Identifiers for NFXL1 Gene

  • GC00U991226
  • GC04M047691
  • GC04M047544
  • GC04M047168

Summaries for NFXL1 Gene

GeneCards Summary for NFXL1 Gene

NFXL1 (Nuclear Transcription Factor, X-Box Binding-Like 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFX1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFXL1 Gene

Genomics for NFXL1 Gene

Regulatory Elements for NFXL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFXL1 Gene

47,847,233 bp from pter
47,914,667 bp from pter
67,435 bases
Minus strand

Genomic View for NFXL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFXL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFXL1 Gene

Proteins for NFXL1 Gene

  • Protein details for NFXL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NF-X1-type zinc finger protein NFXL1
    Protein Accession:
    Secondary Accessions:
    • B1Q2K1
    • Q86VG1
    • Q8WVH1

    Protein attributes for NFXL1 Gene

    911 amino acids
    Molecular mass:
    101339 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18459.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NFXL1 Gene


neXtProt entry for NFXL1 Gene

Proteomics data for NFXL1 Gene at MOPED

Post-translational modifications for NFXL1 Gene

  • Ubiquitination at Lys238, Lys402, Lys534, Lys588, Lys604, Lys661, Lys693, Lys759, and Lys766
  • Modification sites at PhosphoSitePlus

Other Protein References for NFXL1 Gene

No data available for DME Specific Peptides for NFXL1 Gene

Domains for NFXL1 Gene

Protein Domains for NFXL1 Gene

Suggested Antigen Peptide Sequences for NFXL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZNB6
  • Belongs to the NFX1 family.
  • Contains 10 NF-X1-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with NFXL1: view

No data available for Gene Families for NFXL1 Gene

Function for NFXL1 Gene

Gene Ontology (GO) - Molecular Function for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with NFXL1: view

Phenotypes for NFXL1 Gene

genes like me logo Genes that share phenotypes with NFXL1: view

Animal Model Products

miRNA for NFXL1 Gene

miRTarBase miRNAs that target NFXL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NFXL1 Gene

Localization for NFXL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFXL1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NFXL1 Gene COMPARTMENTS Subcellular localization image for NFXL1 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NFXL1: view

Pathways for NFXL1 Gene

SuperPathways for NFXL1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NFXL1 Gene

Gene Ontology (GO) - Biological Process for NFXL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with NFXL1: view

No data available for Pathways by source for NFXL1 Gene

Transcripts for NFXL1 Gene

Unigene Clusters for NFXL1 Gene

Nuclear transcription factor, X-box binding-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFXL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFXL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP4: - -
SP5: -

Relevant External Links for NFXL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFXL1 Gene

mRNA expression in normal human tissues for NFXL1 Gene

Protein differential expression in normal tissues for NFXL1 Gene

This gene is overexpressed in Testis (17.8), Plasma (12.0), Placenta (11.3), and Pancreas (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFXL1 Gene

SOURCE GeneReport for Unigene cluster for NFXL1 Gene Hs.646325

genes like me logo Genes that share expressions with NFXL1: view

Expression partners for NFXL1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFXL1 Gene

Orthologs for NFXL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NFXL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NFXL1 35
  • 91.29 (n)
  • 92.97 (a)
NFXL1 36
  • 92 (a)
(Canis familiaris)
Mammalia NFXL1 35
  • 90.83 (n)
  • 90.65 (a)
NFXL1 36
  • 90 (a)
(Mus musculus)
Mammalia Nfxl1 35
  • 87.52 (n)
  • 89.79 (a)
Nfxl1 16
Nfxl1 36
  • 87 (a)
(Pan troglodytes)
Mammalia NFXL1 35
  • 99.41 (n)
  • 99.23 (a)
NFXL1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nfxl1 35
  • 86.57 (n)
  • 88.58 (a)
(Monodelphis domestica)
Mammalia NFXL1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves NFXL1 35
  • 75.5 (n)
  • 76.9 (a)
NFXL1 36
  • 74 (a)
(Anolis carolinensis)
Reptilia NFXL1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nfxl1 35
  • 70.96 (n)
  • 73.3 (a)
(Danio rerio)
Actinopterygii nfxl1 35
  • 61.71 (n)
  • 63.65 (a)
nfxl1 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005362 35
  • 47.47 (n)
  • 43.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15011 35
  • 49.79 (n)
  • 44.19 (a)
CG15011 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP1 36
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATNFXL2 35
  • 49.63 (n)
  • 43.12 (a)
(Oryza sativa)
Liliopsida Os01g0158900 35
  • 48.68 (n)
  • 41.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for NFXL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFXL1 Gene

Gene Tree for NFXL1 (if available)
Gene Tree for NFXL1 (if available)

Paralogs for NFXL1 Gene

Paralogs for NFXL1 Gene

Selected SIMAP similar genes for NFXL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFXL1: view

Variants for NFXL1 Gene

Sequence variations from dbSNP and Humsavar for NFXL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1371730 -- 47,906,587(-) TTTTT(A/T)AAAAA intron-variant
rs1545200 -- 47,903,800(-) GGGCT(A/G)TGTAG intron-variant
rs1822030 -- 47,905,507(-) CTTGA(C/T)AGCTC intron-variant
rs2053405 -- 47,908,110(-) TCGAT(A/G)TATTT intron-variant
rs2119204 -- 47,903,141(-) AGTTT(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFXL1 Gene

Variant ID Type Subtype PubMed ID
nsv829924 CNV Gain 17160897
nsv4328 CNV Loss 18451855

Relevant External Links for NFXL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFXL1 Gene

Disorders for NFXL1 Gene

(1) University of Copenhagen DISEASES for NFXL1 Gene

Relevant External Links for NFXL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NFXL1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for NFXL1 Gene

Publications for NFXL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for NFXL1 Gene

Sources for NFXL1 Gene

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