Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFX1 Gene

protein-coding   GIFtS: 49
GCID: GC09P033280

nuclear transcription factor, X-box binding 1

 Explore 3 diseases affiliated with
NFX1 via our new
 Human Malady Compendium 
Biological research products
for NFX1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nuclear Transcription Factor, X-Box Binding 11 2
NFX21 2 3
Nuclear Transcription Factor, X Box-Binding Protein 12 3
MGC203691
Transcriptional Repressor NF-X12
EC 6.3.2.-3

External Ids:    HGNC: 78031   Entrez Gene: 47992   Ensembl: ENSG000000861027   OMIM: 6032555   UniProtKB: Q129863   

Export aliases for NFX1 gene to outside databases

Previous GC identifers: GC09P033602 GC09P033459


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFX1:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to
the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded
by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC
class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by
limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each
of which encodes a different isoform, have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986
Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in
regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced
by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with
PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination

Gene Wiki entry for NFX1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFX1 gene promoter:
         Max1   AP-1   p53   ATF-2   STAT3   c-Jun   LCR-F1   c-Ets-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NFX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p12

NFX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFX1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033280:  view genomic region     (about GC identifiers)

Start:
33,290,418 bp from pter      End:
33,371,155 bp from pter
Size:
80,738 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986 (See protein sequence)
Recommended Name: Transcriptional repressor NF-X1  
Size: 1120 amino acids; 124395 Da
Subunit: Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts
with PABPC1 and PABPC4
Subcellular location: Nucleus
Sequence caution: Sequence=AAA69517.1; Type=Frameshift; Positions=78, 202, 284;
Secondary accessions: A8K6H8 Q5VXW6 Q96EL5 Q9BXI1
Alternative splicing: 3 isoforms:  Q12986-1   Q12986-2   Q12986-3   

Explore the universe of human proteins at neXtProt for NFX1: NX_Q12986

Post-translational modifications:

  • Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1
  • is not polyubiquitinated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12986

  • NFX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_002495.2  NP_667344.1  NP_667345.1  

    ENSEMBL proteins: 
     ENSP00000368856   ENSP00000368836   ENSP00000317695  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NFX1
    OriGene Custom Protein Services for NFX1 
    GenScript Custom Purified and Recombinant Proteins Services for NFX1
    Novus Biologicals NFX1 Protein
    Novus Biologicals NFX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NFX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    NFX1 for ontologies           About GeneDecksing



    NFX1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NFX1 
    GenScript Custom Superior Antibodies Services for NFX1
    Novus Biologicals NFX1 Antibodies
    Search for Antibodies for NFX1 at Abcam  
    Uscn Antibodies for NFX1
    Search ThermoFisher Antibodies for NFX1

    Assay Products for NFX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFX1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NFX1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NFX1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000967 Znf_NFX1
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001841 Znf_RING
     IPR001374 R3H_ss-bd
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry Q12986

    ProtoNet protein and cluster: Q12986

    4 Blocks protein families:
    IPB000967 Zn-finger
    IPB001374 Single-stranded nucleic acid binding R3H
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986
    Domain: The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates
    ubiquitination
    Similarity: Belongs to the NFX1 family
    Similarity: Contains 8 NF-X1-type zinc fingers
    Similarity: Contains 1 R3H domain
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986
    Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in
    regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced
    by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with
    PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination
    Induction: By IFNG/IFN-gamma

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): NFX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFX1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate NFX1 (see all 20):
    hsa-miR-3164 hsa-miR-3607-3p hsa-miR-128 hsa-miR-378b hsa-miR-629 hsa-miR-320e hsa-miR-378 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidNFX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFX1 (see all 7)
    OriGene shRNA RFP: NFX1
    OriGene siRNA: NFX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFX1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFX1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFX1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NFX1 (NM_147133)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFX1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFX1
    Search LifeMap BioReagents cell lines for NFX1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFX1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    NFX1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NFX1:
     Upregulation of Wnt/beta-caten 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NFX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/162 Interacting proteins for NFX1 (Q129863 ENSP000003688564) via UniProtKB, MINT, STRING, and/or I2D (see all 162)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    MRE11AP499593, ENSP000003258634I2D: score=6 STRING: ENSP00000325863
    NUP214P356583, ENSP000003524004I2D: score=6 STRING: ENSP00000352400
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS7964459
    GO:0006954inflammatory response TAS7964459
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    NFX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFX1
    Search CenterWatch for drugs/clinical trials and news about NFX1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFX1 gene (3 alternative transcripts): 
    NM_002504.4  NM_147133.2  NM_147134.2  

    Unigene Cluster for NFX1:

    Nuclear transcription factor, X-box binding 1
    Hs.413074  [show with all ESTs]
    Unigene Representative Sequence: NM_002504
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379540(uc003zsq.3 uc003zsr.3) ENST00000379521(uc003zsp.2 uc010mjr.2)
    ENST00000318524(uc011lnw.2 uc003zso.3) ENST00000466359 ENST00000466971
    ENST00000463421

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): NFX1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFX1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate NFX1 (see all 20):
    hsa-miR-3164 hsa-miR-3607-3p hsa-miR-128 hsa-miR-378b hsa-miR-629 hsa-miR-320e hsa-miR-378 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidNFX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFX1 (see all 7)
    OriGene shRNA RFP: NFX1
    OriGene siRNA: NFX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFX1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFX1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFX1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NFX1 (NM_147133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFX1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFX1

    Additional cDNA sequence: 

    AF332009.1 AK225750.1 AK291643.1 AL832342.1 BC006447.1 BC012151.1 BX647337.1 U15306.1 

    19 DOTS entries:

    DT.100025546  DT.40214270  DT.100788161  DT.121187724  DT.100788160  DT.121187931  DT.100788168  DT.428516 
    DT.91651161  DT.121187722  DT.95083728  DT.421634  DT.86859957  DT.91969783  DT.95132329  DT.95132367 
    DT.121187752  DT.95093835  DT.95132366 

    24/288 AceView cDNA sequences (see all 288):

    BX647337 BQ894378 BC012151 AA905447 BQ434879 AA604553 AI301976 AI468184 
    BU428857 AI696922 CD515331 BU620169 AW302497 BM693697 AI287776 BU187330 
    AI871178 AI360004 BF516408 AI421926 AW731785 NM_147133 BE693262 BI091592 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NFX1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
    SP1:                                                                                            -                                 
    SP2:                                                                                            -                                 
    SP3:                                      -     -                                                                                 
    SP4:                                                                                                                              
    SP5:                                      -     -                                                                                 


    ECgene alternative splicing isoforms for NFX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NFX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFX1

    SOURCE GeneReport for Unigene cluster: Hs.413074
        SABiosciences Expression via Pathway-Focused PCR Arrays including NFX1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFX1 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NFX11 nuclear transcription factor, X-box binding 1 66.55(n)
    62.36(a)
      420796  XM_418890.3  XP_418890.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    48(a)
    1 ↔ 1
    4(66805308-66835896)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.182562 Transcribed sequence with moderate similarity to protein more 77.69(n)    BX758948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160862 Transcribed sequence with weak similarity to protein more 76.87(n)    BM860330.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stc1 , 3 neurogenesis RNA polymerase II transcription
    factor3
    shuttle craft1
    43(a)
    (best of 2)3
    48.96(n)1
    43(a)1
      35C23
    348881  NM_057250.31  NP_476598.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C16A3.73
    nfx-11
    human NFX1\; D. melanogaster shuttle craft
    protein3
    Protein NFX-11
    40(a)3
    47.57(n)1
    40.45(a)1
      III(6447153-6450771)3
    1759021  NM_065993.51  NP_498394.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAP11 Fap1p 46.85(n)
    37.5(a)
      855708   NP_014375.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NFXL11 NF-X1-type zinc finger protein NFXL1 45.95(n)
    39.86(a)
      837555  NM_100891.2  NP_172488.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02523001 hypothetical protein 47.43(n)
    43.46(a)
      4340659  NM_001063833.1  NP_001057298.1 


    ENSEMBL Gene Tree for NFX1 (if available)
    TreeFam Gene Tree for NFX1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFX1 gene
    NFXL12  

    NFX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1310 NCBI SNPs in NFX1 are shown (see all 1310    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556753081,2
    C--33288519(+) GGTTGA/GCTGGG 3 -- us2k10--------
    rs1830199301,2
    --33288590(+) AGCAGC/TTGTTT 3 -- us2k10--------
    rs8305771,2
    C,F,--33288610(-) GGTAAA/CAGAGA 3 -- us2k17Minor allele frequency- C:0.18NA WA CSA 11
    rs1996533421,2
    --33288655(+) GTTTT-/TTGTTGTT 3 -- us2k10--------
    rs105506841,2
    --33288688(+) GGCAG-/AGAGTTTT 3 -- us2k10--------
    rs724332911,2
    --33288689(+) GCAGA-/GAGTTTTT 3 -- us2k10--------
    rs1863441791,2
    --33288916(+) ATCCCC/TCTGAT 3 -- us2k10--------
    rs727230461,2
    C,--33289239(+) ACCCCC/TGAAAG 3 -- us2k10--------
    rs781928431,2
    C--33289271(+) CCAGGA/CCTTAG 3 -- us2k10--------
    rs1411893541,2
    C,--33289482(+) GGTCT-/GGG   
       GGGTG
    GGGGG
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NFX1 (33290418 - 33371155 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NFX1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFX1
    DNA2.0 Custom Variant and Variant Library Synthesis for NFX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NFX1 for disorders           About GeneDecksing

    OMIM gene information: 603255    OMIM disorders: --

    3 diseases for NFX1:    About MalaCards
    immunodeficiency    malaria    neuronitis


    Export disorders for NFX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFX1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with NFX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor. (PubMed id 7964459)1, 2, 3, 9 Song Z.... Ono S.J. (1994)
    2. NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. (PubMed id 17267499)1, 2 Katzenellenbogen R.A....Galloway D.A. (2007)
    3. Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. (PubMed id 15371341)1, 2 Gewin L.... Galloway D.A. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (1999)
    6. Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors. (PubMed id 2511169)1, 3 Hume C.R. and Lee J.S. (1989)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity. (PubMed id 20739528)1 Xu M....Galloway D.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4799 HGNC: 7803 AceView: NFX1 Ensembl:ENSG00000086102 euGenes: HUgn4799
    ECgene: NFX1 H-InvDB: NFX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFX1 gene:
    Search GeneIP for patents involving NFX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NFX1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFX1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFX1  
     OriGene Protein Over-expression Lysate for NFX1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NFX1   OriGene 3'-UTR Clone for NFX1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFX1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFX1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFX1   OriGene Custom Protein Services for NFX1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFX1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFX1
     GenScript Custom Purified and Recombinant Proteins Services for NFX1 GenScript cDNA clones with any tag delivered in your preferred vector for NFX1
     GenScript Custom Assay Services for NFX1 GenScript Custom Superior Antibodies Services for NFX1
     GenScript Custom overexpressing Cell Line Services for NFX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NFX1 promoter
     Search Chromatin IP Primers for NFX1
     RT2 qPCR Primer Assay in human, mouse, rat NFX1
     Search GNC Networks for NFX1
     SABiosciences PCR Arrays including human, mouse, rat NFX1
     Search Tocris compounds for NFX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NFX1 antibodies
     NFX1 proteins
     NFX1 lysates
     Search for Antibodies for NFX1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NFX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NFX1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NFX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFX1
     SwitchGear 3'UTR luciferase reporter plasmids for NFX1
     SwitchGear Promoter luciferase reporter plasmids for NFX1
     Search ThermoFisher Antibodies for NFX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFX1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFX1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4