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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFX1 Gene

protein-coding   GIFtS: 51
GCID: GC09P033280

Nuclear Transcription Factor, X-Box Binding 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Transcription Factor, X-Box Binding 11 2
Nuclear Transcription Factor, X Box-Binding Protein 12 3
NFX22 3
Transcriptional Repressor NF-X12
EC 6.3.2.-3

External Ids:    HGNC: 78031   Entrez Gene: 47992   Ensembl: ENSG000000861027   OMIM: 6032555   UniProtKB: Q129863   

Export aliases for NFX1 gene to outside databases

Previous GC identifers: GC09P033602 GC09P033459


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFX1 Gene:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that
bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The
protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of
HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an
inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three
alternative splice variants, each of which encodes a different isoform, have been identified. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NFX1 Gene: 
NFX1 (nuclear transcription factor, X-box binding 1) is a protein-coding gene. Diseases associated with NFX1 include neuronitis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ligase activity. An important paralog of this gene is NFXL1.

UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986
Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important
role in regulating the duration of an inflammatory response by limiting the period in which MHC class II
molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its
expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates
E2-dependent ubiquitination

Gene Wiki entry for NFX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFX1 gene promoter:
         Max1   AP-1   p53   ATF-2   STAT3   c-Jun   LCR-F1   c-Ets-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NFX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p12

NFX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFX1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033280:  view genomic region     (about GC identifiers)

Start:
33,290,418 bp from pter      End:
33,371,155 bp from pter
Size:
80,738 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986 (See protein sequence)
Recommended Name: Transcriptional repressor NF-X1  
Size: 1120 amino acids; 124395 Da
Subunit: Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1
interacts with PABPC1 and PABPC4
Subcellular location: Nucleus
Sequence caution: Sequence=AAA69517.1; Type=Frameshift; Positions=78, 202, 284;
Secondary accessions: A8K6H8 Q5VXW6 Q96EL5 Q9BXI1
Alternative splicing: 3 isoforms:  Q12986-1   Q12986-2   Q12986-3   

Explore the universe of human proteins at neXtProt for NFX1: NX_Q12986

Explore proteomics data for NFX1 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation.
    Isoform 1 is not polyubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12986

  • NFX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NFX1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002495.2  NP_667344.1  NP_667345.1  

    ENSEMBL proteins: 
     ENSP00000368856   ENSP00000368836   ENSP00000317695  

    Human Recombinant Protein Products for NFX1: 
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    Cloud-Clone Corp. Proteins for NFX1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NFX1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for NFX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000967 Znf_NFX1
     IPR001841 Znf_RING
     IPR001374 R3H_ss-bd
     IPR019786 Zinc_finger_PHD-type_CS
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry Q12986

    ProtoNet protein and cluster: Q12986

    4 Blocks protein domains:
    IPB000967 Zn-finger
    IPB001374 Single-stranded nucleic acid binding R3H
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986
    Domain: The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates
    ubiquitination
    Similarity: Belongs to the NFX1 family
    Similarity: Contains 8 NF-X1-type zinc fingers
    Similarity: Contains 1 R3H domain
    Similarity: Contains 1 RING-type zinc finger


    NFX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFX1_HUMAN, Q12986
    Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important
    role in regulating the duration of an inflammatory response by limiting the period in which MHC class II
    molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its
    expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates
    E2-dependent ubiquitination
    Induction: By IFNG/IFN-gamma

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    NFX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NFX1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NFX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/162 Interacting proteins for NFX1 (Q129863 ENSP000003688564) via UniProtKB, MINT, STRING, and/or I2D (see all 162)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    MRE11AP499593, ENSP000003258634I2D: score=6 STRING: ENSP00000325863
    NUP214P356583, ENSP000003524004I2D: score=6 STRING: ENSP00000352400
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS7964459
    GO:0006954inflammatory response TAS7964459
    GO:0019048modulation by virus of host morphology or physiology IEA--

    NFX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFX1

    Search CenterWatch for drugs/clinical trials and news about NFX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFX1 gene (3 alternative transcripts): 
    NM_002504.4  NM_147133.2  NM_147134.2  

    Unigene Cluster for NFX1:

    Nuclear transcription factor, X-box binding 1
    Hs.413074  [show with all ESTs]
    Unigene Representative Sequence: NM_002504
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379540(uc003zsq.3 uc003zsr.3) ENST00000379521(uc003zsp.2 uc010mjr.2)
    ENST00000318524(uc011lnw.2 uc003zso.3) ENST00000466359 ENST00000466971
    ENST00000463421
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    SwitchGear 3'UTR luciferase reporter plasmidNFX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NFX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFX1
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFX1
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    Additional mRNA sequence: 

    AF332009.1 AK225750.1 AK291643.1 AL832342.1 BC006447.1 BC012151.1 BX647337.1 U15306.1 

    19 DOTS entries:

    DT.100025546  DT.40214270  DT.100788161  DT.121187724  DT.100788160  DT.121187931  DT.100788168  DT.428516 
    DT.91651161  DT.121187722  DT.95083728  DT.421634  DT.86859957  DT.91969783  DT.95132329  DT.95132367 
    DT.121187752  DT.95093835  DT.95132366 

    24/288 AceView cDNA sequences (see all 288):

    R98629 BM477265 AI362126 BU620169 CA443228 BQ721867 AI360004 CD515331 
    NM_002504 BE858857 AI287776 AA905447 BE728816 BP871782 BG327231 AA369984 
    AA135897 AW731785 AA905906 BF972691 AI452636 BF063002 CD369874 AL832342 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NFX1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
    SP1:                                                                                            -                                 
    SP2:                                                                                            -                                 
    SP3:                                      -     -                                                                                 
    SP4:                                                                                                                              
    SP5:                                      -     -                                                                                 


    ECgene alternative splicing isoforms for NFX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NFX1 Expression
    About this image


    See NFX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFX1

    SOURCE GeneReport for Unigene cluster: Hs.413074
        SABiosciences Expression via Pathway-Focused PCR Arrays including NFX1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFX1 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfx11 , 5 nuclear transcription factor, X-box binding 11, 5 87.64(n)1
    88.69(a)1
      4 (20.72 cM)5
    741641  NM_023739.31  NP_076228.21 
     409709065 
    chicken
    (Gallus gallus)
    Aves NFX11 nuclear transcription factor, X-box binding 1 66.55(n)
    62.36(a)
      420796  XM_418890.3  XP_418890.3 
    lizard
    (Anolis carolinensis)
    Reptilia NFX16
    nuclear transcription factor, X-box binding 1
    59(a)
    1 ↔ 1
    4(66784812-66839997)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.182562 Transcribed sequence with moderate similarity to protein more 77.69(n)    BX758948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160862 Transcribed sequence with weak similarity to protein more 76.87(n)    BM860330.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stc1 , 3 neurogenesis RNA polymerase II
    transcription factor3
    shuttle craft1
    43(a)
    (best of 2)3
    48.96(n)1
    43(a)1
      35C23
    348881  NM_057250.31  NP_476598.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C16A3.73
    nfx-11
    human NFX1\; D. melanogaster shuttle
    craft protein3
    Protein NFX-11
    40(a)3
    47.57(n)1
    40.45(a)1
      III(6447153-6450771)3
    1759021  NM_065993.51  NP_498394.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAP11 Fap1p 46.85(n)
    37.5(a)
      855708   NP_014375.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NFXL11 NF-X1-type zinc finger protein NFXL1 45.95(n)
    39.86(a)
      837555  NM_100891.2  NP_172488.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02523001 hypothetical protein 47.43(n)
    43.46(a)
      4340659  NM_001063833.1  NP_001057298.1 


    ENSEMBL Gene Tree for NFX1 (if available)
    TreeFam Gene Tree for NFX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFX1 gene
    NFXL12  

    NFX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1674 SNPs in NFX1 are shown (see all 1674)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556753081,2
    C--33257752(+) GGTTGA/GCTGGG 3 -- us2k10--------
    rs1830199301,2
    --33257823(+) AGCAGC/TTGTTT 3 -- us2k10--------
    rs8305771,2
    C,F--33257843(-) GGTAAA/CAGAGA 3 -- us2k17Minor allele frequency- C:0.18NA WA CSA 11
    rs1996533421,2
    C--33257888(+) GGTTT-/TTGTGTTG 3 -- us2k10--------
    rs105506841,2
    --33257921(+) GGCAG-/AGAGTTTT 6 -- us2k1 cds10--------
    rs724332911,2
    --33257922(+) GCAGA-/GAGTTTTT 3 -- us2k10--------
    rs1863441791,2
    --33258149(+) ATCCCC/TCTGAT 3 -- us2k10--------
    rs727230461,2
    C--33258472(+) ACCCCC/TGAAAG 3 -- us2k10--------
    rs781928431,2
    C--33258504(+) CCAGGA/CCTTAG 3 -- us2k10--------
    rs1411893541,2
    C--33258715(+) GGTCT-/GGG   
       GGGTG
    GGGGG
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NFX1 (33290418 - 33371155 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NFX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8439CNV Loss18304495
    nsv6524CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603255    OMIM disorders: --

    2 diseases for NFX1:    About MalaCards
    neuronitis    


    NFX1 for disorders           About GeneDecksing


    Export disorders for NFX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFX1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with NFX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor. (PubMed id 7964459)1, 2, 3, 9 Song Z.... Ono S.J. (1994)
    2. NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. (PubMed id 17267499)1, 2 Katzenellenbogen R.A....Galloway D.A. (2007)
    3. Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. (PubMed id 15371341)1, 2 Gewin L.... Galloway D.A. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (1999)
    6. Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors. (PubMed id 2511169)1, 3 Hume C.R. and Lee J.S. (1989)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4799 HGNC: 7803 AceView: NFX1 Ensembl:ENSG00000086102 euGenes: HUgn4799
    ECgene: NFX1 H-InvDB: NFX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFX1 gene:
    Search GeneIP for patents involving NFX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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