Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NFX1 Gene

protein-coding   GIFtS: 52
GCID: GC09P033280

Nuclear Transcription Factor, X-Box Binding 1

  Search for NFX1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Transcription Factor, X-Box Binding 11 2     Tex422
Nuclear Transcription Factor, X Box-Binding Protein 12 3     Transcriptional Repressor NF-X12
NFX22 3     EC 6.3.2.-3
TEG-422     

External Ids:    HGNC: 78031   Entrez Gene: 47992   Ensembl: ENSG000000861027   OMIM: 6032555   UniProtKB: Q129863   

Export aliases for NFX1 gene to outside databases

Previous GC identifers: GC09P033602 GC09P033459


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NFX1 Gene:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that
bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The
protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of
HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an
inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three
alternative splice variants, each of which encodes a different isoform, have been identified. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NFX1 Gene:
NFX1 (nuclear transcription factor, X-box binding 1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ligase activity. An important paralog of this gene is NFXL1.

UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986
Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important
role in regulating the duration of an inflammatory response by limiting the period in which MHC class II
molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its
expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates
E2-dependent ubiquitination

Gene Wiki entry for NFX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFX1 gene promoter:
         Max1   AP-1   p53   ATF-2   STAT3   c-Jun   LCR-F1   c-Ets-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFX1 promoter sequence
   Search Chromatin IP Primers for NFX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p12

NFX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFX1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033280:  view genomic region     (about GC identifiers)

Start:
33,290,418 bp from pter      End:
33,371,155 bp from pter
Size:
80,738 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986 (See protein sequence)
Recommended Name: Transcriptional repressor NF-X1  
Size: 1120 amino acids; 124395 Da
Subunit: Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1
interacts with PABPC1 and PABPC4
Sequence caution: Sequence=AAA69517.1; Type=Frameshift; Positions=78, 202, 284;
Secondary accessions: A8K6H8 Q5VXW6 Q96EL5 Q9BXI1
Alternative splicing: 3 isoforms:  Q12986-1   Q12986-2   Q12986-3   

Explore the universe of human proteins at neXtProt for NFX1: NX_Q12986

Explore proteomics data for NFX1 at MOPED

Post-translational modifications: 

  • Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation.
    Isoform 1 is not polyubiquitinated1
  • Ubiquitination2 at Lys548, Lys885
  • Modification sites at PhosphoSitePlus

  • See NFX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002495.2  NP_667344.1  NP_667345.1  

    ENSEMBL proteins: 
     ENSP00000368856   ENSP00000368836   ENSP00000317695  

    NFX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NFX1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NFX1
    GenScript Custom Purified and Recombinant Proteins Services for NFX1
    Novus Biologicals NFX1 Protein
    Novus Biologicals NFX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NFX1

     
    Search eBioscience for Proteins for NFX1 

    NFX1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NFX1
    Novus Biologicals NFX1 Antibodies
    Abcam antibodies for NFX1
    Cloud-Clone Corp. Antibodies for NFX1
    Search ThermoFisher Antibodies for NFX1
    LSBio Antibodies in human, mouse, rat for NFX1

    NFX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NFX1
    Cloud-Clone Corp. CLIAs for NFX1
    Search eBioscience for ELISAs for NFX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR000967 Znf_NFX1
     IPR001841 Znf_RING
     IPR001374 R3H_ss-bd
     IPR019786 Zinc_finger_PHD-type_CS
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry Q12986

    ProtoNet protein and cluster: Q12986

    4 Blocks protein domains:
    IPB000967 Zn-finger
    IPB001374 Single-stranded nucleic acid binding R3H
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: NFX1_HUMAN, Q12986
    Domain: The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates
    ubiquitination
    Similarity: Belongs to the NFX1 family
    Similarity: Contains 8 NF-X1-type zinc fingers
    Similarity: Contains 1 R3H domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with NFX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFX1_HUMAN, Q12986
    Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important
    role in regulating the duration of an inflammatory response by limiting the period in which MHC class II
    molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its
    expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates
    E2-dependent ubiquitination
    Induction: By IFNG/IFN-gamma

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with NFX1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NFX1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFX1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NFX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFX1 (see all 20):
    hsa-miR-3164 hsa-miR-3607-3p hsa-miR-128 hsa-miR-378b hsa-miR-629 hsa-miR-320e hsa-miR-378 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidNFX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFX1
    Predesigned siRNA for gene silencing in human, mouse, rat NFX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFX1

    Clone
    Products:
         
    OriGene clones in human, mouse for NFX1 (see all 19)
    OriGene ORF clones in mouse, rat for NFX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NFX1 (NM_147133)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NFX1_HUMAN, Q12986: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with NFX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NFX1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    2mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40



        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFX1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NFX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFX1 (Q129863 ENSP000003688564) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    MRE11AP499593, ENSP000003258634I2D: score=6 STRING: ENSP00000325863
    NUP214P356583, ENSP000003524004I2D: score=6 STRING: ENSP00000352400
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS7964459
    GO:0006954inflammatory response TAS7964459
    GO:0016032viral process IEA--

    Find genes that share ontologies with NFX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NFX1 gene (3 alternative transcripts): 
    NM_002504.4  NM_147133.2  NM_147134.2  

    Unigene Cluster for NFX1:

    Nuclear transcription factor, X-box binding 1
    Hs.413074  [show with all ESTs]
    Unigene Representative Sequence: NM_002504
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379540(uc003zsq.3 uc003zsr.3) ENST00000379521(uc003zsp.2 uc010mjr.2)
    ENST00000318524(uc011lnw.2 uc003zso.3) ENST00000466359 ENST00000466971
    ENST00000463421
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFX1 (see all 20):
    hsa-miR-3164 hsa-miR-3607-3p hsa-miR-128 hsa-miR-378b hsa-miR-629 hsa-miR-320e hsa-miR-378 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidNFX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFX1
    Predesigned siRNA for gene silencing in human, mouse, rat NFX1
    Clone
    Products:
         
    OriGene clones in human, mouse for NFX1 (see all 19)
    OriGene ORF clones in mouse, rat for NFX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NFX1 (NM_147133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFX1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFX1
    OriGene qSTAR qPCR primer pairs in human, mouse for NFX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFX1
      QuantiTect SYBR Green Assays in human, mouse, rat NFX1
      QuantiFast Probe-based Assays in human, mouse, rat NFX1

    Additional mRNA sequence: 

    AF332009.1 AK225750.1 AK291643.1 AL832342.1 BC006447.1 BC012151.1 BX647337.1 U15306.1 

    19 DOTS entries:

    DT.100025546  DT.40214270  DT.100788161  DT.121187724  DT.100788160  DT.121187931  DT.100788168  DT.428516 
    DT.91651161  DT.121187722  DT.95083728  DT.421634  DT.86859957  DT.91969783  DT.95132329  DT.95132367 
    DT.121187752  DT.95093835  DT.95132366 

    Selected AceView cDNA sequences (see all 288):

    AI452636 CD637436 BM793125 AI421338 AI362126 NM_147134 BU428857 AW302497 
    AL832342 BU187330 AI871178 AI696922 BU620169 BC012151 BE879668 AA369984 
    BM477265 BE390068 AI468184 BU633584 BQ721867 BQ019420 BU623775 BE390243 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFX1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
    SP1:                                                                                            -                                 
    SP2:                                                                                            -                                 
    SP3:                                      -     -                                                                                 
    SP4:                                                                                                                              
    SP5:                                      -     -                                                                                 


    ECgene alternative splicing isoforms for NFX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NFX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NFX1 Expression
    About this image

    NFX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413074
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFX1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFX1
    OriGene qSTAR qPCR primer pairs in human, mouse for NFX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFX1
    QuantiTect SYBR Green Assays in human, mouse, rat NFX1
    QuantiFast Probe-based Assays in human, mouse, rat NFX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NFX1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfx11 , 5 nuclear transcription factor, X-box binding 11, 5 87.64(n)1
    88.69(a)1
      4 (20.72 cM)5
    741641  NM_023739.31  NP_076228.21 
     409709065 
    chicken
    (Gallus gallus)
    Aves NFX11 nuclear transcription factor, X-box binding 1 66.76(n)
    62.52(a)
      420796  XM_004935068.1  XP_004935125.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFX16
    nuclear transcription factor, X-box binding 1
    59(a)
    1 ↔ 1
    4(66784812-66839997)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.182562 Transcribed sequence with moderate similarity to protein more 77.69(n)    BX758948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160862 Transcribed sequence with weak similarity to protein more 76.87(n)    BM860330.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stc1 , 3 neurogenesis RNA polymerase II
    transcription factor3
    shuttle craft1
    43(a)
    (best of 2)3
    49.16(n)1
    42.93(a)1
      35C23
    348881  NM_001273531.11  NP_001260460.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C16A3.73
    nfx-11
    human NFX1\; D. melanogaster shuttle
    craft protein3
    nfx-11
    40(a)3
    47.56(n)1
    40.62(a)1
      III(6447153-6450771)3
    1759021  NM_065993.61  NP_498394.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAP11 FAP1 47.09(n)
    36.96(a)
      855708   NP_014375.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NFXL11 NFXL1 47.03(n)
    41.09(a)
      837555  NM_100891.2  NP_172488.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02523001 Os06g0252300 47.49(n)
    43.33(a)
      4340659  NM_001063833.1  NP_001057298.1 


    ENSEMBL Gene Tree for NFX1 (if available)
    TreeFam Gene Tree for NFX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NFX1 gene
    NFXL12  

    Find genes that share paralogs with NFX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NFX1 (see all 1674)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556753081,2
    C--33257752(+) GGTTGA/GCTGGG 3 -- us2k10--------
    rs1830199301,2
    --33257823(+) AGCAGC/TTGTTT 3 -- us2k10--------
    rs8305771,2
    C,F--33257843(-) GGTAAA/CAGAGA 3 -- us2k17Minor allele frequency- C:0.18NA WA CSA 11
    rs1996533421,2
    C--33257888(+) GGTTT-/TTGTGTTG 3 -- us2k10--------
    rs105506841,2
    --33257921(+) GGCAG-/AGAGTTTT 6 -- us2k1 cds10--------
    rs724332911,2
    --33257922(+) GCAGA-/GAGTTTTT 3 -- us2k10--------
    rs1863441791,2
    --33258149(+) ATCCCC/TCTGAT 3 -- us2k10--------
    rs727230461,2
    C--33258472(+) ACCCCC/TGAAAG 3 -- us2k10--------
    rs781928431,2
    C--33258504(+) CCAGGA/CCTTAG 3 -- us2k10--------
    rs1411893541,2
    C--33258715(+) GGTCT-/GGG   
       GGGTG
    GGGGG
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NFX1 (33290418 - 33371155 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NFX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8439CNV Loss18304495
    nsv6524CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFX1
    DNA2.0 Custom Variant and Variant Library Synthesis for NFX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603255    OMIM disorders: --


    Find genes that share disorders with NFX1           About GenesLikeMe


    Export disorders for NFX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NFX1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with NFX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor. (PubMed id 7964459)1, 2, 3, 9 Song Z.... Ono S.J. (J. Exp. Med. 1994)
    2. NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. (PubMed id 17267499)1, 2 Katzenellenbogen R.A.... Galloway D.A. (J. Virol. 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. (PubMed id 15371341)1, 2 Gewin L.... Galloway D.A. (Genes Dev. 2004)
    5. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors. (PubMed id 2511169)1, 3 Hume C.R. and Lee J.S. (Hum. Immunol. 1989)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes. (PubMed id 24109236)1 Vliet-Gregg P.A....Katzenellenbogen R.A. (J. Virol. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4799 HGNC: 7803 AceView: NFX1 Ensembl:ENSG00000086102 euGenes: HUgn4799
    ECgene: NFX1 H-InvDB: NFX1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NFX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NFX1 gene:
    Search GeneIP for patents involving NFX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NFX1  
     OriGene qPCR primer pairs and template standards for NFX1   OriGene Protein Over-expression Lysate for NFX1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NFX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFX1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NFX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFX1   OriGene Custom Protein Services for NFX1  

     
     
     Block miRNA regulation of human, mouse, rat NFX1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NFX1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFX1 Predesigned siRNA for gene silencing in human, mouse, rat NFX1
     QuantiFast Probe-based Assays in human, mouse, rat NFX1 QuantiTect SYBR Green Assays in human, mouse, rat NFX1
     PCR Arrays including human, mouse, rat NFX1 Search Chromatin IP Primers for NFX1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFX1  Search GeneGlobe Interaction Network for NFX1
     Regulatory tfbs in NFX1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NFX1 GenScript cDNA clones with any tag delivered in your preferred vector for NFX1
     GenScript Custom Assay Services for NFX1 GenScript Custom overexpressing Cell Line Services for NFX1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NFX1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NFX1 antibodies
     NFX1 proteins
     NFX1 lysates
     Antibodies for NFX1
     See all of Abcam's Antibodies, Kits and Proteins for NFX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NFX1
     Antibodies for NFX1
     ELISAs for NFX1
     CLIAs for NFX1



     Browse ESI BIO Cell Lines and PureStem Progenitors for NFX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFX1
     SwitchGear 3'UTR luciferase reporter plasmids for NFX1
     SwitchGear Promoter luciferase reporter plasmids for NFX1
     Search ThermoFisher Antibodies for NFX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFX1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFX1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFX1
     LSBio Antibodies in human, mouse, rat for NFX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NFX1
      Search eBioscience for proteins for NFX1
      Search eBioscience for elisas for NFX1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFX1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4