NFU1 Gene
protein-coding GIFtS: 52
GCID: GC02M069622
|
|
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)(Previous name: HIRA interacting protein 5 ) (Previous symbol: HIRIP5)
| |
Aliases for NFU1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| NFU1 Iron-Sulfur Cluster Scaffold Homolog (S. Cerevisiae)1 2 | | HIRIP2 | | HIRIP51 2 3 5 | | MMDS12 | | NIFUC1 2 | | Nfu2 | | NifU1 2 | | Iron-Sulfur Cluster Scaffold Protein2 | | HIRA-Interacting Protein 52 3 | | NFU1 Iron-Sulfur Cluster Scaffold Homolog, Mitochondrial2 | | CGI-331 | | NifU-Like C-Terminal Domain Containing2 | | HIRA Interacting Protein 51 | | |
Export aliases for NFU1 gene to outside databasesPrevious GC identifers: GC02M069477 GC02M069359 |
Summaries for NFU1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for NFU1: This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur clusterbiogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinatedehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctionssyndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively splicedtranscript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011) UniProtKB/Swiss-Prot: NFU1_HUMAN, Q9UMS0Function: Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins
|
Genomic Views for NFU1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NFU1 gene promoter: Max1 USF1 AML1a Meis-1b AREB6 USF-1 Meis-1a Meis-1 RSRFC4 Other transcription factors
Search SABiosciences Chromatin IP Primers for NFU1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFU1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p15-p13 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p15-p13NFU1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M069622: view genomic region
(about GC identifiers)
Start:
|
69,622,882 bp from pter |
End:
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69,664,760 bp from pter |
Size:
|
41,879 bases |
Orientation:
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minus strand |
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Proteins for NFU1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: NFU1_HUMAN, Q9UMS0 (See
protein sequence)Recommended Name: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial precursor Size: 254 amino acids; 28463 Da
Subunit: Interacts with HIRA and EPM2A/laforin
Subcellular location: Mitochondrion. Cytoplasm, cytosol
Developmental stage: Expressed in embryo and adult
Sequence caution: Sequence=AAD27742.1; Type=Frameshift; Positions=5, 16, 115, 117; Sequence=AAY14828.1; Type=Erroneousgene model prediction; Sequence=BAG36716.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAB53015.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for NFU1:2LTM (3D)
 
Secondary accessions: B4DUL9 Q53QE5 Q6VNZ8 Q7Z5B1 Q7Z5B2 Q9Y322Alternative splicing: 3 isoforms: Q9UMS0-1 Q9UMS0-2 Q9UMS0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NFU1: NX_Q9UMS0
NFU1 Protein expression data from MOPED and PaxDb: About this image 

REFSEQ proteins (3 alternative transcripts):
NP_001002755.1 NP_001002756.1 NP_056515.2 ENSEMBL proteins: ENSP00000387219 ENSP00000418882 ENSP00000306965 ENSP00000418598 ENSP00000415102 ENSP00000417693 ENSP00000405495 ENSP00000393338 ENSP00000377842 Human Recombinant Protein Products for NFU1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NFU1 for ontologies About GeneDecksing
NFU1 Antibody Products: Assay Products for NFU1: |
Protein
Domains / Families for NFU1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NFU1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UMS0ProtoNet protein and cluster: Q9UMS0 1 Blocks protein family: IPB001075 Nitrogen-fixing NifU
UniProtKB/Swiss-Prot: NFU1_HUMAN, Q9UMS0Similarity: Belongs to the NifU family |
Function for NFU1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: NFU1_HUMAN, Q9UMS0Function: Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
NFU1 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFU1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFU1 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): NFU1 (NM_001002755) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NFU1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFU1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFU1 |
|
Pathways & Interactions for NFU1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NFU1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
 5/26 Interacting proteins for NFU1 (Q9UMS01, 2, 3 ENSP000003872194) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016226 | iron-sulfur cluster assembly |
IDA | 12886008 |
NFU1 for ontologies About GeneDecksing
|
Drugs & Compounds for NFU1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NFU1 for compounds About GeneDecksing
Browse Tocris compounds for NFU1
1 HMDB Compound for NFU1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Iron | Armco iron (see all 19) | 7439-89-6 | -- | 4 Novoseek chemical compound relationships for NFU1 gene About this table
Search CenterWatch for drugs/clinical trials and news about NFU1 
|
Transcripts for NFU1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NFU1 gene (4 alternative transcripts): NM_001002755.2 NM_001002756.2 NM_015700.3 NM_001002757.1 Unigene Cluster for NFU1: NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) Hs.430439 [show with all ESTs]Unigene Representative Sequence: BX53834710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000410022(uc002sfj.3 uc002sfk.3 uc002sfm.3 uc010fdi.3 uc002sfn.2) ENST00000471185 ENST00000474230 ENST00000303698 ENST00000462320 ENST00000450796 ENST00000484177 ENST00000419370 ENST00000438184 ENST00000394305(uc002sfl.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFU1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFU1 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): NFU1 (NM_001002755) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NFU1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFU1  |
Additional cDNA sequence: AF132967.1 AJ132584.1 AK300700.1 AK308567.1 AK314004.1 AY286306.1 AY286307.1 AY335194.1 BC113692.1 BC113694.1 BX538347.1 NR_045631.1 NR_045632.1 12 DOTS entries: DT.101983365 DT.100785594 DT.99934120 DT.100785592 DT.120944857 DT.100785591 DT.120944891 DT.95102804 DT.100036120 DT.100785593 DT.92013410 DT.100036119 24/140 AceView cDNA sequences (see all 140): BM763845 AI304712 CA867269 BM694187 BM763836 CA447183 CR621922 AW298703 BM978940 CB321762 BX398479 AI382688 CA420143 BM704717 AJ132584 NM_001002755 CA431406 AA252159 NM_001002756 W81412 CD365057 BF475477 NM_015700 BM692922 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NFU1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for NFU1
|
Expression for NFU1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NFU1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTGCAGTTTT
 About this image See NFU1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NFU1
SOURCE GeneReport for Unigene cluster: Hs.430439
UniProtKB/Swiss-Prot: NFU1_HUMAN, Q9UMS0Tissue specificity: Ubiquitous. Expression in adult lung is weak compared to fetal lung SABiosciences Custom PCR Arrays for NFU1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFU1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFU1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFU1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFU1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFU1 |
Orthologs for NFU1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NFU1 gene from 10/38 species (see all 38) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Nfu11 , 5 |
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)1, 5 |
85.73(n)1 89.2(a)1 |
  |
6 (37.76 cM)5 567481 NM_001170591.11 NP_001164062.11 870092365 |
chicken (Gallus gallus) |
Aves |
NFU11 |
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) |
76.85(n) 80.75(a) |
  |
419513 NM_001006305.2 NP_001006305.2 |
lizard (Anolis carolinensis) |
Reptilia |
NFU16 |
-- |
77(a) |
1 ↔ 1 |
GL344011.1(2127-5724) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.14672 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.91(n) |
  |
CA973778.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.10422 |
Danio rerio clone RK075A4E01 HIRA interacting protein more |
76.45(n) |
  |
AY398357.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG335021 |
CG33502 |
59.89(n) 66.31(a) |
  |
2768875 NM_206806.2 NP_996529.1 |
worm (Caenorhabditis elegans) |
Secernentea |
lpd-81 |
Protein LPD-8 |
58.96(n) 57.29(a) |
  |
177928 NM_069516.3 NP_501917.1 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
NFU1(YKL040C)4 NFU11 |
Protein involved in iron metabolism in mitochondria; more4 Nfu1p1 |
50.51(n)1 43.43(a)1 |
  |
11(361828-361058)4 8538261, 4 NP_012884.31 NP_012884.14 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
NFU41 |
NifU-like protein 4 |
60.21(n) 58.12(a) |
  |
821647 NM_112989.2 NP_566673.1 |
rice (Oryza sativa) |
Liliopsida |
Os.78182 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
69.27(n) |
  |
NM_185273.1 |
ENSEMBL Gene Tree for NFU1 (if available) TreeFam Gene Tree for NFU1 (if available)  |
Paralogs for NFU1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for NFU1 gene
NFU1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for NFU1 PGOHUM00000244809 PGOHUM00000238002
|
Genomic Variants for NFU1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NFU1 (69622882 - 69664760 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for NFU1 1 CNV: 7279 Human Gene Mutation Database (HGMD): NFU1
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFU1 |
|
Disorders
/ Diseases for NFU1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NFU1 for disorders About GeneDecksing
OMIM gene information: 608100
OMIM disorders: --
UniProtKB/Swiss-Prot: NFU1_HUMAN, Q9UMS0
Defects in NFU1 are the cause of multiple mitochondrial dysfunctions syndrome type 1 (MMDS1) [MIM:605711]. Asevere disorder of systemic energy metabolism, resulting in weakness, respiratory failure, lack of neurologicdevelopment, lactic acidosis, hyperglycinemia and early death. Some patients show failure to thrive, pulmonaryhypertension, hypotonia and irritability. Biochemical features include severe combined deficiency of the 2-oxoaciddehydrogenases, defective lipoic acid synthesis and reduction in activity of mitochondrial respiratory chain complexes 10 diseases for NFU1: About MalaCardsmultiple mitochondrial dysfunctions syndrome multiple mitochondrial dysfunctions syndrome 1 lafora disease genital herpes lactic acidosis respiratory failure hypotonia malaria pancreatic cancer pancreatitis 3 diseases from the University of Copenhagen DISEASES database for NFU1:Genital herpes Epilepsy with generalized tonic-clonic seizures Lafora disease 1 Novoseek disease relationship for NFU1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lafora disease |
79.7 |
5 |
12915448 (2), 15651314 (1) |
Human Genome Epidemiology (HuGE) Navigator: NFU1 (1 document) Export disorders for NFU1 gene to outside databases
|
Publications for NFU1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NFU1 gene, integrated from 9 sources (see all 31): (articles sorted by number of sources associating them with NFU1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. (PubMed id 12886008)1, 2, 3, 9 Tong W.H....Rouault T.A. (2003)
- Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins. (PubMed id 11342215)1, 2, 3, 9 Lorain S.... Lipinski M. (2001)
- The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain. (PubMed id 12915448)1, 2, 9 Ganesh S.... Yamakawa K. (2003)
- A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins. (PubMed id 22077971)1, 2 Navarro-Sastre A.... Lill R. (2011)
- Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes. (PubMed id 21944046)1, 2 Cameron J.M.... Robinson B.H. (2011)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Iron-sulfur cluster biosynthesis: characterization of a molten globule domain in human NFU. (PubMed id 19722697)1 Liu Y. and Cowan J.A. (2009)
|
External Searches for NFU1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NFU1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NFU1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NFU1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for NFU1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NFU1 gene: Search GeneIP for patents involving NFU1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for NFU1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for NFU1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFU1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFU1 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for NFU1 | | OriGene 3'-UTR Clone for NFU1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFU1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFU1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for NFU1 | | OriGene Custom Protein Services for NFU1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFU1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFU1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFU1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFU1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFU1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFU1 |
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| | | Search Tocris compounds for NFU1 |
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 | | NFU1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFU1 |
|  |  |  |  | | | ThermoFisher Antibody for NFU1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFU1 |
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