Aliases for NFU1 Gene
External Ids for NFU1 Gene
Previous HGNC Symbols for NFU1 Gene
Previous GeneCards Identifiers for NFU1 Gene
This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for NFU1 Gene
NFU1 (NFU1 Iron-Sulfur Cluster Scaffold) is a Protein Coding gene. Diseases associated with NFU1 include Multiple Mitochondrial Dysfunctions Syndrome 1 and Fatal Multiple Mitochondrial Dysfunction Syndrome Type 1. GO annotations related to this gene include iron ion binding and iron-sulfur cluster binding.
UniProtKB/Swiss-Prot for NFU1 Gene
Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins.