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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NFS1 Gene

protein-coding GIFtS: 57
GCID: GC20M034220

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

(Previous names: nitrogen fixation 1 (S. cerevisiae, homolog) )

Explore 9 diseases affiliated with
NFS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NFS1 Nitrogen Fixation 1 Homolog (S. Cerevisiae)¹ ²		EC 2.8.1.7³ ⁸
NIFS² ³ ⁵		NifS¹
IscS¹ ²		Cysteine Desulfurase, Mitochondrial²
Nitrogen Fixation 1 (S. Cerevisiae, Homolog)¹ ²		Nitrogen-Fixing Bacteria S-Like Protein²

External Ids:	HGNC: 15910¹	Entrez Gene: 9054²	Ensembl: ENSG00000244005⁷	OMIM: 603485⁵	UniProtKB: Q9Y697³

Export aliases for NFS1 gene to outside databases

Previous GC identifers: GC20U990032 GC20M033975 GC20M034925 GC20M034972 GC20M033720 GC20M034256 GC20M031036

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFS1:

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply

inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene

uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms.

Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the

class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been

described. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: NFS1_HUMAN, Q9Y697

Function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur

for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor

Gene Wiki entry for NFS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NFS1 gene promoter:
GR Pbx1a AML1a GR-beta NF-kappaB C/EBPalpha ZIC2/Zic2 Msx-1 GR-alpha NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NFS1 promoter sequence

Search SABiosciences Chromatin IP Primers for NFS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.22

NFS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFS1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M034220: view genomic region (about GC identifiers)

Start:	34,220,262 bp from pter	End:	34,287,281 bp from pter
Size:	67,020 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NFS1_HUMAN, Q9Y697 (See protein sequence)

Recommended Name: Cysteine desulfurase, mitochondrial precursor

Size: 457 amino acids; 50196 Da

Cofactor: Pyridoxal phosphate (By similarity)

Subunit: Binds ISCU/NIFUN. Forms a complex with LYRM4

Subcellular location: Isoform Mitochondrial: Mitochondrion

Subcellular location: Isoform Cytoplasmic: Cytoplasm. Nucleus

Secondary accessions: B3KMA5 B4DXK9 E1P5R8 F5GYK5 Q6P0L8 Q9NTZ5 Q9Y481

Alternative splicing, Alternative initiation: 3 isoforms: Q9Y697-1 Q9Y697-2 Q9Y697-3

Explore the universe of human proteins at neXtProt for NFS1: NX_Q9Y697

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y697

4/14 DME Specific Peptides for NFS1 (Q9Y697) (see all 14)

KGVARFY

EGESLLM

AHSSIRF

GGGQERG

NFS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001185918.1 NP_066923.3

ENSEMBL proteins:

ENSP00000411232 ENSP00000395201 ENSP00000443983 ENSP00000363205 ENSP00000363198

ENSP00000380570 ENSP00000392871 ENSP00000393669 ENSP00000397572 ENSP00000393482

ENSP00000403253 ENSP00000304740 ENSP00000440897 ENSP00000438594

Reactome Protein details: Q9Y697
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	Uscn Proteins for NFS1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16847322
GO:0005739	mitochondrion	TAS	9885568
GO:0005759	mitochondrial matrix	IDA	16847322
GO:0005829	cytosol	TAS	--

NFS1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NFS1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR020578 Aminotrans_V_PyrdxlP_BS

IPR015424 PyrdxlP-dep_Trfase

IPR010240 Cys_deSase

IPR000192 Aminotrans_V/Cys_dSase

IPR016454 Cysteine_dSase_NifS

Graphical View of Domain Structure for InterPro Entry Q9Y697

ProtoNet protein and cluster: Q9Y697

1 Blocks protein family: IPB000192 Aminotransferase

UniProtKB/Swiss-Prot: NFS1_HUMAN, Q9Y697

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NFS1_HUMAN, Q9Y697

Function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur

for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor

Catalytic activity: L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor

Biophysicochemical properties: Kinetic parameters: KM=434.75 uM for L-cysteine; Note=Kinetic parameter was determined

for the protein lacking the 55 N-terminus amino-acids and in a complex with LYRM4;

Enzyme Number (IUBMB): EC 2.8.1.7¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0005515	protein binding	IPI	18650437
GO:0030170	pyridoxal phosphate binding	IEA	--
GO:0031071	cysteine desulfurase activity	TAS	--
GO:0042803	protein homodimerization activity	IDA	16527810

NFS1 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFS1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Molybdenum cofactor biosynthesis

	Molybdenum cofactor biosynthesis	1.00			Sulfur relay system	0.33
	molybdenum cofactor biosynthesis	0.67

Mitochondrial Iron-Sulfur Cluster Biogenesis

Mitochondrial Iron-Sulfur Cluster Biogenesis

1.00

FXN:NFS1:ISD11:ISCU Synthesizes Iron-Sulfur Cluster

0.67

Vitamin B5 (pantothenate) metabolism

Metabolism of vitamins and cofactors

0.21

Metabolism of water-soluble vitamins and cofactors

0.21

Metabolism

Metabolism

1.00

alanine biosynthesis III

alanine biosynthesis III

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for NFS1

	alanine biosynthesis III
	molybdenum cofactor biosynthesis

5/6 Reactome Pathways for NFS1 (see all 6)

	Molybdenum cofactor biosynthesis
	Mitochondrial Iron-Sulfur Cluster Biogenesis
	Metabolism
	Metabolism of vitamins and cofactors
	Metabolism of water-soluble vitamins and cofactors

2 Kegg Pathways (Kegg details for NFS1):

	Thiamine metabolism
	Sulfur relay system

NFS1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NFS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for NFS1 (Q9Y697³ ENSP00000363205⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519³, ENSP00000361423⁴	I2D: score=1 STRING: ENSP00000361423
FYN	P06241³, ENSP00000357656⁴	I2D: score=1 STRING: ENSP00000357656
GAPDH	P04406³, ENSP00000229239⁴	I2D: score=1 STRING: ENSP00000229239
MOCS3	O95396³, ENSP00000244051⁴	I2D: score=1 STRING: ENSP00000244051
RB1CC1	Q8TDY2³, ENSP00000025008⁴	I2D: score=1 STRING: ENSP00000025008

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000096	sulfur amino acid metabolic process	TAS	9885568
GO:0006461	protein complex assembly	TAS	9885568
GO:0006534	cysteine metabolic process	IEA	--
GO:0006766	vitamin metabolic process	TAS	--
GO:0006767	water-soluble vitamin metabolic process	TAS	--

NFS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NFS1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NFS1

4 HMDB Compounds for NFS1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Iron	Armco iron (see all 19)	7439-89-6	--
L-Alanine	(2S)-2-Aminopropanoate (see all 35)	56-41-7	--
L-Cysteine	(+)-2-Amino-3-mercaptopropionic acid (see all 37)	52-90-4	--
Pyridoxal 5'-phosphate	Apolon B6 (see all 27)	54-47-7	--

3 DrugBank Compounds for NFS1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Cysteine	(R)-2-Amino-3-mercaptopropanoic acid (see all 13)	52-90-4	target	--	16877383 16603772 15828873 15985427 17469805
Pyridoxal Phosphate	Codecarboxylase (see all 9)	54-47-7	target	cofactor	12119030 12196163 12860127 17469805 16310786
L-Alanine	(2S)-2-Aminopropanoic acid (see all 15)	56-41-7	target	--	17469805 17660944

10/12 Novoseek chemical compound relationships for NFS1 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
iron-sulfur	85.8	6	16527810 (2), 9885568 (1), 9812986 (1), 20064440 (1)
moco	78.5	2	17368066 (1), 16784786 (1)
cysteine	74.2	43	16527810 (4), 12382038 (4), 18191630 (2), 9812986 (2) (see all 22)
sulfur	73.4	17	9812986 (2), 9885568 (1), 18191630 (1), 11060020 (1) (see all 11)
molybdopterin	70.4	2	12382038 (1), 11029694 (1)
pyridoxal 5-phosphate	68.2	6	14756555 (1), 11123951 (1), 12382038 (1), 9264543 (1)
selenocysteine	56.6	2	9812986 (2)
iron	44.6	2	16527810 (1), 11555280 (1)
alanine	28.8	4	9812986 (2), 10891064 (1), 12382038 (1)
selenium	24.7	7	9812986 (5), 10609891 (1)

Search CenterWatch for drugs/clinical trials and news about NFS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NFS1 gene (3 alternative transcripts):

NM_001198989.1 NM_021100.4 NM_181679.1

Unigene Cluster for NFS1:

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

Hs.194692 [show with all ESTs]

Unigene Representative Sequence: AK056242

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000441563 ENST00000454607 ENST00000541176(uc002xdn.1 uc002xdo.1 uc002xdp.1)

ENST00000374092(uc010zvl.2 uc010zvk.2 uc002xdw.2) ENST00000374085(uc002xdt.2)

ENST00000498084 ENST00000480655 ENST00000397425 ENST00000440385 ENST00000471137

ENST00000489163 ENST00000413203 ENST00000456462 ENST00000419569 ENST00000421540

ENST00000306750(uc002xdx.3) ENST00000541387 ENST00000540053

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Additional cDNA sequence:

AF097025.2 AJ010952.1 AK001265.1 AK001470.1 AK056242.1 AK223239.1 AK295215.1 AK297969.1

AK301969.1 AK302023.1 AK312293.1 BC018471.1 BC065560.1 NR_037570.2

20 DOTS entries:

DT.91755144 DT.120831356 DT.100809563 DT.95073681 DT.120831403 DT.453288 DT.100818245 DT.100818247

DT.120831317 DT.100818251 DT.100818248 DT.100818249 DT.95073682 DT.91710310 DT.100808665 DT.120831218

DT.120831365 DT.120831379 DT.120831455 DT.95356653

24/189 AceView cDNA sequences (see all 189):

CR594451 BC018471 AA832096 BM704466 CD671950 AK091049 BQ073152 AI214202

F10023 BX437580 N91044 AI041708 CA454242 R55097 AK001470 BC065560

BP366656 BU736632 BF939784 CB216201 AI471710 CR610756 NM_181679 CF139792

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NFS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACATTTGAG

About this image

NFS1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NFS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NFS1

SOURCE GeneReport for Unigene cluster: Hs.194692

UniProtKB/Swiss-Prot: NFS1_HUMAN, Q9Y697

Tissue specificity: Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NFS1 gene from 11/42 species (see all 42) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nfs1^{1 , 5}	nitrogen fixation gene 1 (S. cerevisiae)^{1, 5}	86.99(n)¹ 92.46(a)¹		2 (77.34 cM)⁵ 18041¹ NM_010911.2¹ NP_035041.2¹ 156078929⁵
chicken (Gallus gallus)	Aves	F1NNU3_CHICK⁶	NFS1 nitrogen fixation 1	79(a)	1 ↔ 1	20(1028253-1040388)
lizard (Anolis carolinensis)	Reptilia	NFS1⁶	--	87(a)	1 ↔ 1	4(134414874-134427826)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6508²	Xenopus laevis transcribed sequence with moderate similarity more	75.8(n)		CA789097.1
zebrafish (Danio rerio)	Actinopterygii	nfs1¹	NFS1 nitrogen fixation 1 (S. cerevisiae)	73.71(n) 82.34(a)		562714 NM_001044993.1 NP_001038458.1
fruit fly (Drosophila melanogaster)	Insecta	CG12264^{1 , 3}	iron-sulfur cluster assembly cysteine desulfhydrase³ CG12264¹	67(a)³ 66.17(n)¹ 78.3(a)¹		33B5³ 34613¹ NM_135689.2¹ NP_609533.1¹
worm (Caenorhabditis elegans)	Secernentea	B0205.6^{1 , 3}	aminotransferase³ Protein B0205.6¹	65(a)³ 63.84(n)¹ 70.07(a)¹		I(10744802-10747827)³ 172979¹ NM_060411.4¹ NP_492812.2¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NFS1(YCL017C)⁴ NFS1¹	Cysteine desulfurase involved in iron-sulfur cluster more⁴ Nfs1p¹	58.09(n)¹ 63.88(a)¹		3(94270-92777)⁴ 850343^{1, 4} NP_009912.2^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	NFS1¹	cysteine desulfurase 1	62.18(n) 67.08(a)		836701 NM_125969.2 NP_201373.1
rice (Oryza sativa)	Liliopsida	Os.9367²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.3(n)		AK098947.1

ENSEMBL Gene Tree for NFS1 (if available)
TreeFam Gene Tree for NFS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NFS1 gene

SCLY²

9 SIMAP similar genes for NFS1 using alignment to 12 protein entries: NFS1_HUMAN (see all proteins):

AURA2 SPATS2L LEPROTL1 SH3PXD2A TMEM14B HMGA2

EPS15 FAM175A SCLY

NFS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181908833^1,2		--	34256240(+)	`ATAAGA/GAATAC`	3	--	ds500¹		0	--	--	--	--
rs6088912^1,2	H	--	34256390(+)	`CTCTAG/ATTACA`	3	--	ds500¹		4		NS EA	416
rs6121023^1,2	C,F,A,H	--	34256640(+)	`GTTTAA/CTTATT`	3	--	ut3¹ nc-transcript-variant		20		NS EA NA WA CSA	2346
rs185251941^1,2		--	34256682(+)	`TGAGGA/GCAGGG`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs146515370^1,2		--	34256823(+)	`GGCGG-/GGTTCTTC`	3	--	nc-transcript-variantut3¹		0	--	--	--	--
rs190492301^1,2		--	34256953(+)	`ATTAGA/TATAAC`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs145437310^1,2		--	34256975(+)	`CAGACA/GTATTT`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs181949135^1,2		--	34257075(+)	`GTCAAC/TATGAA`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs186119647^1,2		--	34257173(+)	`AAGACA/GAAGAC`	3	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs7267759^1,2	C,F,A,H	--	34257284(+)	`TGACAG/TCAAAT`	3	--	ut3¹ nc-transcript-variant		12		NA NS EA WA	880

HapMap Linkage Disequilibrium report for NFS1 (34220262 - 34287281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NFS1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFS1

DNA2.0 Custom Variant and Variant Library Synthesis for NFS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NFS1 for disorders           About GeneDecksing

OMIM gene information: 603485    OMIM disorders: --

9 diseases for NFS1:    About MalaCards

xanthinuria sickle cell anemia friedreich ataxia anemia

ataxia pneumonia tuberculosis malaria

mycobacterium tuberculosis

2 diseases from the University of Copenhagen DISEASES database for NFS1:

Friedreich ataxia Sickle cell anemia

Human Genome Epidemiology (HuGE) Navigator: NFS1 (1 document)

Export disorders for NFS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NFS1 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with NFS1)

Utopia: connect your pdf to the dynamic
world of online information

Targeting of a human iron-sulfur cluster assembly enzyme, nifs, to different subcellular compartments is regulated through alternative AUG utilization. (PubMed id 9885568)^{1, 2, 3, 9} Land T. and Rouault T.A. (1998)
Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. (PubMed id 11060020)^{1, 2, 9} Tong W.-H. and Rouault T. (2000)
A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis. (PubMed id 18650437)^{1, 2} Marelja Z.... Leimkuehler S. (2008)
Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. (PubMed id 16847322)^{1, 3} Biederbick A....Lill R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)^{1, 2} Stanchi F.... Valle G. (2001)
Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly. (PubMed id 16527810)^{1, 9} Li K....Rouault T.A. (2006)
Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis. (PubMed id 19454487)^{2, 9} Shi Y....Rouault T.A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9054	HGNC: 15910	AceView: NFS1	Ensembl:ENSG00000244005	euGenes: HUgn9054
ECgene: NFS1	Kegg: 9054	H-InvDB: NFS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NFS1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NFS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NFS1 gene:
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GeneCards and IP:
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NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

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NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

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