Aliases for NFS1 Gene
External Ids for NFS1 Gene
Previous GeneCards Identifiers for NFS1 Gene
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
GeneCards Summary for NFS1 Gene
NFS1 (NFS1 Cysteine Desulfurase) is a Protein Coding gene. Diseases associated with NFS1 include severe neonatal lactic acidosis due to nfs1-isd11 complex deficiency and xanthinuria. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include protein homodimerization activity and cysteine desulfurase activity. An important paralog of this gene is ENSG00000272897.
UniProtKB/Swiss-Prot for NFS1 Gene
Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.