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NFRKB Gene

protein-coding   GIFtS: 52
GCID: GC11M129733

Nuclear Factor Related To KappaB Binding Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor Related To KappaB Binding Protein1 2     DNA-Binding Protein R Kappa-B2 3
INO80 Complex Subunit G1 2 3     Nuclear Factor Related To Kappa B Binding Protein1
DNA-Binding Protein R Kappa B1 2     Nuclear Factor Related To Kappa-B-Binding Protein2
INO80G2 3     

External Ids:    HGNC: 78021   Entrez Gene: 47982   Ensembl: ENSG000001703227   OMIM: 1640135   UniProtKB: Q6P4R83   

Export aliases for NFRKB gene to outside databases

Previous GC identifers: GC11M131734 GC11M131246 GC11M129767 GC11M129271 GC11M129272 GC11M129238 GC11M125685


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NFRKB Gene:
NFRKB (nuclear factor related to kappaB binding protein) is a protein-coding gene. Diseases associated with NFRKB include nephrotic syndrome, and multiple myeloma. GO annotations related to this gene include protease binding.

UniProtKB/Swiss-Prot: NFRKB_HUMAN, Q6P4R8
Function: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'
Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of
UCHL5 in the INO80 complex

Gene Wiki entry for NFRKB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFRKB gene promoter:
         PPAR-alpha   IRF-2   ARP-1   ZIC2/Zic2   Nkx2-5   Hlf   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFRKB promoter sequence
   Search Chromatin IP Primers for NFRKB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFRKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24-q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24-q25

NFRKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFRKB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M129733:  view genomic region     (about GC identifiers)

Start:
129,733,531 bp from pter      End:
129,765,490 bp from pter
Size:
31,960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NFRKB_HUMAN, Q6P4R8 (See protein sequence)
Recommended Name: Nuclear factor related to kappa-B-binding protein  
Size: 1299 amino acids; 139001 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated
with the N-terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5
Sequence caution: Sequence=AAA17871.1; Type=Frameshift; Positions=1267;
1 PDB 3D structure from and Proteopedia for NFRKB:
3U21 (3D)    
Secondary accessions: Q12869 Q15312 Q9H048
Alternative splicing: 3 isoforms:  Q6P4R8-1   Q6P4R8-2   Q6P4R8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFRKB: NX_Q6P4R8

Explore proteomics data for NFRKB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys148, Lys1207
  • Modification sites at PhosphoSitePlus

  • See NFRKB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137307.1  NP_006156.2  

    ENSEMBL proteins: 
     ENSP00000400476   ENSP00000436926   ENSP00000433572   ENSP00000432606   ENSP00000433730  
     ENSP00000431854   ENSP00000434326   ENSP00000432520   ENSP00000431247   ENSP00000433764  
     ENSP00000303800  

    NFRKB Human Recombinant Protein Products:

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    OriGene Custom Protein Services for NFRKB
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    Novus Biologicals NFRKB Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NFRKB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for NFRKB
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    NFRKB Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    INO80: INO80 complex subunits

    2 InterPro protein domains:
     IPR025220 NFRKB_winged_dom
     IPR024867 NFRKB

    Graphical View of Domain Structure for InterPro Entry Q6P4R8

    ProtoNet protein and cluster: Q6P4R8

    UniProtKB/Swiss-Prot: NFRKB_HUMAN, Q6P4R8
    Domain: NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA
    Similarity: Belongs to the NFRKB family


    NFRKB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFRKB_HUMAN, Q6P4R8
    Function: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'
    Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
    transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of
    UCHL5 in the INO80 complex

         Genatlas biochemistry entry for NFRKB:
    nuclear transcription factor related to kappa B binding protein

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI18922472
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI18922472
         
    NFRKB for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NFRKB:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFRKB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFRKB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFRKB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFRKB

    miRNA
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    Block miRNA regulation of human, mouse, rat NFRKB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFRKB (see all 14):
    hsa-miR-3163 hsa-miR-516b hsa-miR-15a hsa-miR-4297 hsa-miR-497 hsa-miR-378b hsa-miR-422a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidNFRKB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFRKB
    Predesigned siRNA for gene silencing in human, mouse, rat NFRKB

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NFRKB

    Clone
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    OriGene ORF clones in mouse, rat for NFRKB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFRKB (NM_006165)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFRKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFRKB

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NFRKB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFRKB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFRKB_HUMAN, Q6P4R8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0031011colocalizes with Ino80 complex IDA18922472

    NFRKB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFRKB: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NFRKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for NFRKB (Q6P4R81, 2, 3 ENSP000004004764) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    ENSG00000235068Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS1777480
    GO:0006954inflammatory response TAS1777480

    NFRKB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFRKB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NFRKB gene (2 alternative transcripts): 
    NM_001143835.1  NM_006165.3  

    Unigene Cluster for NFRKB:

    Nuclear factor related to kappaB binding protein
    Hs.530539  [show with all ESTs]
    Unigene Representative Sequence: NM_001143835
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446488(uc001qfi.3 uc001qfh.3) ENST00000524794 ENST00000524746(uc010sbw.1)
    ENST00000531755 ENST00000532147 ENST00000530278 ENST00000532225 ENST00000529319
    ENST00000526940 ENST00000526884 ENST00000531318 ENST00000304521(uc009zcr.3 uc001qfg.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFRKB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFRKB (see all 14):
    hsa-miR-3163 hsa-miR-516b hsa-miR-15a hsa-miR-4297 hsa-miR-497 hsa-miR-378b hsa-miR-422a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidNFRKB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFRKB
    Predesigned siRNA for gene silencing in human, mouse, rat NFRKB
    Clone
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    OriGene clones in human, mouse for NFRKB (see all 12)
    OriGene ORF clones in mouse, rat for NFRKB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFRKB (NM_006165)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFRKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFRKB
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NFRKB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFRKB
      QuantiTect SYBR Green Assays in human, mouse, rat NFRKB
      QuantiFast Probe-based Assays in human, mouse, rat NFRKB

    Additional mRNA sequence: 

    AK126294.1 AL512730.1 BC063280.1 X80878.1 

    16 DOTS entries:

    DT.451583  DT.91975369  DT.95124049  DT.100660344  DT.70105238  DT.92440869  DT.102830607  DT.92049438 
    DT.92440863  DT.97827479  DT.120752355  DT.120752374  DT.91746596  DT.100730477  DT.95093525  DT.99994712 

    Selected AceView cDNA sequences (see all 164):

    AI220093 BQ896679 BM473349 AI887378 AI674270 AV707700 BM973964 AV650257 
    BM931173 AL699406 BU184587 BM466805 AL512730 CA393429 AI150201 BQ002708 
    BE048949 BU753897 BG696307 BM669158 CK824713 BU553796 BM984964 BQ576184 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFRKB (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                          -           -     -     -                 -                                                                                       
    SP4:                          -     -     -     -     -                 -                                                                                       
    SP5:                    -     -     -     -     -     -                 -                                                                                       

    ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                -                           
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for NFRKB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NFRKB expression in normal human tissues (normalized intensities)      NFRKB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGTCCAGA
    NFRKB Expression
    About this image


    NFRKB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Neural Tube (Nervous System)
             Telencephalon
    NFRKB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFRKB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530539

    UniProtKB/Swiss-Prot: NFRKB_HUMAN, Q6P4R8
    Tissue specificity: Expressed in thymus, brain, testes, spleen and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFRKB: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NFRKB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFRKB
    QuantiTect SYBR Green Assays in human, mouse, rat NFRKB
    QuantiFast Probe-based Assays in human, mouse, rat NFRKB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFRKB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NFRKB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfrkb1 , 5 nuclear factor related to kappa B binding protein1, 5 88.68(n)1
    94.21(a)1
      9 (16.86 cM)5
    2351341  NM_172766.31  NP_766354.21 
     313861925 
    chicken
    (Gallus gallus)
    Aves NFRKB1 nuclear factor related to kappaB binding protein 74.03(n)
    81.08(a)
      419730  NM_001198556.1  NP_001185485.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFRKB6
    nuclear factor related to kappaB binding protein
    75(a)
    1 ↔ 1
    GL343197.1(215040-235837)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC758712 hypothetical protein MGC75871 75.27(n)    BC063348.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054902.12   -- 74.54(n)    BC054902.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD238763 transcription factor 41(a)   85C1   --


    ENSEMBL Gene Tree for NFRKB (if available)
    TreeFam Gene Tree for NFRKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFRKB (see all 968)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166329681,2
    F--129733194(+) CACCAT/CCTCTA 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1900685561,2
    --129733285(+) GCAGCC/GTCCGC 2 -- int10--------
    rs1995571731,2
    C--129733300(+) GGCTT-/GGCAAGC 2 -- int10--------
    rs1415226101,2
    C--129733364(+) CGCCCA/GGCTAA 2 -- int10--------
    rs600136391,2
    C,F--129733392(+) GAGACG/AGGGTT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1830734871,2
    --129733404(+) CACCAA/TGTTGT 2 -- int10--------
    rs1862594891,2
    --129733417(+) AGGATA/GGTCTC 2 -- int10--------
    rs1906299721,2
    C--129733447(+) CCGCCC/TGCCTT 2 -- int10--------
    rs1476913771,2
    --129733448(+) CGCCCA/GCCTTG 2 -- int10--------
    rs1425014211,2
    C--129733506(+) CACAA-/AAAC  
            
    AAACA
    2 -- int10--------

    HapMap Linkage Disequilibrium report for NFRKB (129733531 - 129765490 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NFRKB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745255CNV Deletion23290073
    esv269495CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFRKB
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164013    OMIM disorders: --

    7 diseases for NFRKB:    About MalaCards
    nephrotic syndrome    multiple myeloma    myeloma    hepatitis b
    hepatitis    alzheimer's disease    cerebritis


    NFRKB for disorders           About GeneDecksing

    Genetic Association Database (GAD): NFRKB
    Human Genome Epidemiology (HuGE) Navigator: NFRKB (6 documents)

    Export disorders for NFRKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFRKB gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with NFRKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of a novel winged-helix like domain from human NFRKB protein. (PubMed id 22984442)1, 2 Kumar A.... Wilson I.A. (PLoS ONE 2012)
    2. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (J. Biol. Chem. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    7. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T.... Conaway J.W. (Mol. Cell 2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Localization of the gene encoding R kappa B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25. (PubMed id 1427843)1, 3 Adams B.S....Nabel G.J. (Genomics 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4798 HGNC: 7802 AceView: NFRKB Ensembl:ENSG00000170322 euGenes: HUgn4798
    ECgene: NFRKB H-InvDB: NFRKB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NFRKB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NFRKB gene:
    Search GeneIP for patents involving NFRKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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