Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NFRKB Gene

Aliases for NFRKB Gene

  • Nuclear Factor Related To KappaB Binding Protein 2 3
  • INO80 Complex Subunit G 2 3 4
  • DNA-Binding Protein R Kappa B 2 3
  • DNA-Binding Protein R Kappa-B 3 4
  • INO80G 3 4
  • Nuclear Factor Related To Kappa B Binding Protein 2
  • Nuclear Factor Related To Kappa-B-Binding Protein 3

External Ids for NFRKB Gene

Previous GeneCards Identifiers for NFRKB Gene

  • GC11M131734
  • GC11M131246
  • GC11M129767
  • GC11M129271
  • GC11M129272
  • GC11M129238
  • GC11M125685
  • GC11M129733

Summaries for NFRKB Gene

GeneCards Summary for NFRKB Gene

NFRKB (Nuclear Factor Related To KappaB Binding Protein) is a Protein Coding gene. GO annotations related to this gene include protease binding.

UniProtKB/Swiss-Prot for NFRKB Gene

  • Binds to the DNA consensus sequence 5-GGGGAATCTCC-3.

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

Gene Wiki entry for NFRKB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFRKB Gene

Genomics for NFRKB Gene

Regulatory Elements for NFRKB Gene

Genomic Location for NFRKB Gene

Start:
129,863,636 bp from pter
End:
129,895,595 bp from pter
Size:
31,960 bases
Orientation:
Minus strand

Genomic View for NFRKB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFRKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFRKB Gene

Proteins for NFRKB Gene

  • Protein details for NFRKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4R8-NFRKB_HUMAN
    Recommended name:
    Nuclear factor related to kappa-B-binding protein
    Protein Accession:
    Q6P4R8
    Secondary Accessions:
    • Q12869
    • Q15312
    • Q9H048

    Protein attributes for NFRKB Gene

    Size:
    1299 amino acids
    Molecular mass:
    139001 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5.
    SequenceCaution:
    • Sequence=AAA17871.1; Type=Frameshift; Positions=1267; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFRKB Gene

    Alternative splice isoforms for NFRKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFRKB Gene

Proteomics data for NFRKB Gene at MOPED

Post-translational modifications for NFRKB Gene

  • Ubiquitination at Lys148 and Lys1207
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NFRKB Gene

Domains for NFRKB Gene

Gene Families for NFRKB Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for NFRKB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NFRKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P4R8

UniProtKB/Swiss-Prot:

NFRKB_HUMAN :
  • Q6P4R8
Domain:
  • NFRKB seems to be mostly disordered. The wing-helix like domain doesnt bind DNA
Family:
  • Belongs to the NFRKB family.
genes like me logo Genes that share domains with NFRKB: view

Function for NFRKB Gene

Molecular function for NFRKB Gene

GENATLAS Biochemistry: nuclear transcription factor related to kappa B binding protein
UniProtKB/Swiss-Prot Function: Binds to the DNA consensus sequence 5-GGGGAATCTCC-3.
UniProtKB/Swiss-Prot Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

Gene Ontology (GO) - Molecular Function for NFRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 18922472
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18922472
genes like me logo Genes that share ontologies with NFRKB: view
genes like me logo Genes that share phenotypes with NFRKB: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NFRKB Gene

Localization for NFRKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFRKB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFRKB Gene COMPARTMENTS Subcellular localization image for NFRKB gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NFRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0031011 colocalizes_with Ino80 complex IDA 18922472
genes like me logo Genes that share ontologies with NFRKB: view

Pathways for NFRKB Gene

SuperPathways for NFRKB Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NFRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 1777480
GO:0006954 inflammatory response TAS 1777480
genes like me logo Genes that share ontologies with NFRKB: view

No data available for Pathways by source for NFRKB Gene

Transcripts for NFRKB Gene

Unigene Clusters for NFRKB Gene

Nuclear factor related to kappaB binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFRKB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NFRKB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFRKB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^
SP1:
SP2:
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7:
SP8:
SP9: -
SP10:
SP11: - - -
SP12:
SP13:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for NFRKB Gene

GeneLoc Exon Structure for
NFRKB
ECgene alternative splicing isoforms for
NFRKB

Expression for NFRKB Gene

mRNA expression in normal human tissues for NFRKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFRKB Gene

SOURCE GeneReport for Unigene cluster for NFRKB Gene Hs.530539

mRNA Expression by UniProt/SwissProt for NFRKB Gene

Q6P4R8-NFRKB_HUMAN
Tissue specificity: Expressed in thymus, brain, testes, spleen and liver.
genes like me logo Genes that share expressions with NFRKB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NFRKB Gene

Orthologs for NFRKB Gene

This gene was present in the common ancestor of animals.

Orthologs for NFRKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFRKB 35
  • 99.55 (n)
  • 99.7 (a)
NFRKB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFRKB 35
  • 85.47 (n)
  • 92.71 (a)
NFRKB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFRKB 35
  • 91.13 (n)
  • 96.64 (a)
NFRKB 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfrkb 35
  • 88.68 (n)
  • 94.21 (a)
Nfrkb 16
Nfrkb 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFRKB 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFRKB 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfrkb 35
  • 88.68 (n)
  • 93.83 (a)
chicken
(Gallus gallus)
Aves NFRKB 35
  • 74.03 (n)
  • 81.08 (a)
NFRKB 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFRKB 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75871 35
nfrkb 35
  • 66.03 (n)
  • 69.75 (a)
zebrafish
(Danio rerio)
Actinopterygii NFRKB 36
  • 58 (a)
OneToOne
wu:fi86h10 35
  • 62.32 (n)
  • 62.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11970 36
  • 21 (a)
OneToOne
BcDNA:LD23876 37
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6838 36
  • 28 (a)
OneToOne
Species with no ortholog for NFRKB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFRKB Gene

ENSEMBL:
Gene Tree for NFRKB (if available)
TreeFam:
Gene Tree for NFRKB (if available)

Paralogs for NFRKB Gene

No data available for Paralogs for NFRKB Gene

Variants for NFRKB Gene

Sequence variations from dbSNP and Humsavar for NFRKB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1016364 -- 129,874,977(-) AGAGT(C/T)CAAAT intron-variant
rs1030467 -- 129,874,357(-) AGGTG(A/G)GTTTT intron-variant
rs1054783 -- 129,863,863(+) GAGCA(A/G)AAGGT utr-variant-3-prime
rs1131972 -- 129,884,749(+) CCTGC(A/G)GTTTT synonymous-codon, reference
rs1161663 -- 129,879,123(+) CCCTG(A/T)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFRKB Gene

Variant ID Type Subtype PubMed ID
esv2745255 CNV Deletion 23290073
esv269495 CNV Insertion 20981092

Relevant External Links for NFRKB Gene

HapMap Linkage Disequilibrium report
NFRKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFRKB Gene

Disorders for NFRKB Gene

Relevant External Links for NFRKB

Genetic Association Database (GAD)
NFRKB
Human Genome Epidemiology (HuGE) Navigator
NFRKB
genes like me logo Genes that share disorders with NFRKB: view

No data available for UniProtKB/Swiss-Prot for NFRKB Gene

Publications for NFRKB Gene

  1. Localization of the gene encoding R kappa B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25. (PMID: 1427843) Adams B.S. … Nabel G.J. (Genomics 1992) 2 3
  2. Cloning of R kappa B, a novel DNA-binding protein that recognizes the interleukin-2 receptor alpha chain kappa B site. (PMID: 1777480) Adams B.S. … Nabel G.J. (New Biol. 1991) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4

Products for NFRKB Gene

  • Addgene plasmids for NFRKB

Sources for NFRKB Gene

Back to Top

Content