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Aliases for NFRKB Gene

Aliases for NFRKB Gene

  • Nuclear Factor Related To KappaB Binding Protein 2 3 5
  • INO80 Complex Subunit G 2 3 4
  • DNA-Binding Protein R Kappa B 2 3
  • INO80G 3 4
  • Nuclear Factor Related To Kappa B Binding Protein 2
  • Nuclear Factor Related To Kappa-B-Binding Protein 3
  • DNA-Binding Protein R Kappa-B 4

External Ids for NFRKB Gene

Previous GeneCards Identifiers for NFRKB Gene

  • GC11M131734
  • GC11M131246
  • GC11M129767
  • GC11M129271
  • GC11M129272
  • GC11M129238
  • GC11M125685
  • GC11M129733

Summaries for NFRKB Gene

GeneCards Summary for NFRKB Gene

NFRKB (Nuclear Factor Related To KappaB Binding Protein) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Metabolism of proteins. GO annotations related to this gene include protease binding.

UniProtKB/Swiss-Prot for NFRKB Gene

  • Binds to the DNA consensus sequence 5-GGGGAATCTCC-3.

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

Gene Wiki entry for NFRKB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFRKB Gene

Genomics for NFRKB Gene

Regulatory Elements for NFRKB Gene

Enhancers for NFRKB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F129852 1.3 FANTOM5 Ensembl ENCODE 36.4 +41.3 41287 3.1 MLX ARID4B FEZF1 YY1 ZNF548 SP5 MIER2 PPARG KAT8 MIER3 NFRKB TMEM45B GC11P129833 GC11M129886
GH11F129860 1.3 FANTOM5 Ensembl ENCODE 36 +34.0 34035 2.6 ELF3 PKNOX1 SIN3A RAD21 RFX5 FOS CREM MIXL1 PAF1 SP5 NFRKB TMEM45B ST14 GC11M129886 GC11P129833
GH11F129845 1.3 FANTOM5 Ensembl ENCODE 24.9 +48.9 48934 2.1 HDAC1 PKNOX1 KLF17 SIN3A FOS ZNF362 CEBPB PBX2 STAT3 ZNF24 NFRKB TMEM45B ST14 GC11P129833 GC11M129886
GH11F129894 0.6 ENCODE 22.8 +0.1 86 1.8 TBP PKNOX1 ZNF76 ARID4B DMAP1 ZNF48 ZNF2 GLIS2 EGR2 THAP11 NFRKB TMEM45B PRDM10 GC11P129888
GH11F129826 0.9 Ensembl ENCODE 18.2 +66.9 66874 3.7 ELF3 MLX ARID4B RAD21 ZSCAN9 ZNF48 RARA YY1 SLC30A9 GATA4 TMEM45B NFRKB ARHGAP32 GC11P129833 GC11M129824 PIR42447
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NFRKB on UCSC Golden Path with GeneCards custom track

Promoters for NFRKB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190801 195 1601 TBP PKNOX1 ZNF76 DMAP1 ZNF48 ZNF2 GLIS2 EGR2 THAP11 GMEB2

Genomic Location for NFRKB Gene

Chromosome:
11
Start:
129,863,636 bp from pter
End:
129,895,595 bp from pter
Size:
31,960 bases
Orientation:
Minus strand

Genomic View for NFRKB Gene

Genes around NFRKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFRKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFRKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFRKB Gene

Proteins for NFRKB Gene

  • Protein details for NFRKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4R8-NFRKB_HUMAN
    Recommended name:
    Nuclear factor related to kappa-B-binding protein
    Protein Accession:
    Q6P4R8
    Secondary Accessions:
    • Q12869
    • Q15312
    • Q9H048

    Protein attributes for NFRKB Gene

    Size:
    1299 amino acids
    Molecular mass:
    139001 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5.
    SequenceCaution:
    • Sequence=AAA17871.1; Type=Frameshift; Positions=1267; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFRKB Gene

    Alternative splice isoforms for NFRKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFRKB Gene

Post-translational modifications for NFRKB Gene

  • Ubiquitination at Lys 148 and Lys 1207
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NFRKB Gene

Domains & Families for NFRKB Gene

Gene Families for NFRKB Gene

Protein Domains for NFRKB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NFRKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P4R8

UniProtKB/Swiss-Prot:

NFRKB_HUMAN :
  • NFRKB seems to be mostly disordered. The wing-helix like domain doesnt bind DNA.
  • Belongs to the NFRKB family.
Domain:
  • NFRKB seems to be mostly disordered. The wing-helix like domain doesnt bind DNA.
Family:
  • Belongs to the NFRKB family.
genes like me logo Genes that share domains with NFRKB: view

Function for NFRKB Gene

Molecular function for NFRKB Gene

GENATLAS Biochemistry:
nuclear transcription factor related to kappa B binding protein
UniProtKB/Swiss-Prot Function:
Binds to the DNA consensus sequence 5-GGGGAATCTCC-3.
UniProtKB/Swiss-Prot Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

Gene Ontology (GO) - Molecular Function for NFRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 18922472
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18922472
genes like me logo Genes that share ontologies with NFRKB: view
genes like me logo Genes that share phenotypes with NFRKB: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NFRKB Gene

Localization for NFRKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFRKB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFRKB Gene COMPARTMENTS Subcellular localization image for NFRKB gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NFRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18922472
GO:0005654 nucleoplasm IDA --
GO:0031011 colocalizes_with Ino80 complex IEA,IDA 18922472
genes like me logo Genes that share ontologies with NFRKB: view

Pathways & Interactions for NFRKB Gene

genes like me logo Genes that share pathways with NFRKB: view

Gene Ontology (GO) - Biological Process for NFRKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 1777480
genes like me logo Genes that share ontologies with NFRKB: view

No data available for SIGNOR curated interactions for NFRKB Gene

Transcripts for NFRKB Gene

Unigene Clusters for NFRKB Gene

Nuclear factor related to kappaB binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFRKB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^
SP1:
SP2:
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7:
SP8:
SP9: -
SP10:
SP11: - - -
SP12:
SP13:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for NFRKB Gene

GeneLoc Exon Structure for
NFRKB
ECgene alternative splicing isoforms for
NFRKB

Expression for NFRKB Gene

mRNA expression in normal human tissues for NFRKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFRKB Gene

This gene is overexpressed in Tlymphocyte (14.7), CD8 Tcells (13.2), and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFRKB Gene



Protein tissue co-expression partners for NFRKB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFRKB Gene:

NFRKB

SOURCE GeneReport for Unigene cluster for NFRKB Gene:

Hs.530539

mRNA Expression by UniProt/SwissProt for NFRKB Gene:

Q6P4R8-NFRKB_HUMAN
Tissue specificity: Expressed in thymus, brain, testes, spleen and liver.
genes like me logo Genes that share expression patterns with NFRKB: view

Primer Products

No data available for mRNA differential expression in normal tissues for NFRKB Gene

Orthologs for NFRKB Gene

This gene was present in the common ancestor of animals.

Orthologs for NFRKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFRKB 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia NFRKB 34 35
  • 91.13 (n)
oppossum
(Monodelphis domestica)
Mammalia NFRKB 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfrkb 34 16 35
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Nfrkb 34
  • 88.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFRKB 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFRKB 34 35
  • 85.47 (n)
chicken
(Gallus gallus)
Aves NFRKB 34 35
  • 74.03 (n)
lizard
(Anolis carolinensis)
Reptilia NFRKB 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfrkb 34
  • 66.03 (n)
MGC75871 34
zebrafish
(Danio rerio)
Actinopterygii wu:fi86h10 34
  • 62.32 (n)
NFRKB 35
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD23876 36
  • 41 (a)
CG11970 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6838 35
  • 28 (a)
OneToOne
Species where no ortholog for NFRKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFRKB Gene

ENSEMBL:
Gene Tree for NFRKB (if available)
TreeFam:
Gene Tree for NFRKB (if available)

Paralogs for NFRKB Gene

No data available for Paralogs for NFRKB Gene

Variants for NFRKB Gene

Sequence variations from dbSNP and Humsavar for NFRKB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1016364 -- 129,874,977(-) AGAGT(C/T)CAAAT intron-variant
rs1030467 -- 129,874,357(-) AGGTG(A/G)GTTTT intron-variant
rs1054783 -- 129,863,863(+) GAGCA(A/G)AAGGT utr-variant-3-prime
rs10691694 -- 129,893,410(+) AAAAA(A/T)TCAGC intron-variant, upstream-variant-2KB
rs10894158 -- 129,866,262(+) CTGTA(C/T)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFRKB Gene

Variant ID Type Subtype PubMed ID
esv2745255 CNV deletion 23290073
esv3361985 CNV insertion 20981092

Variation tolerance for NFRKB Gene

Residual Variation Intolerance Score: 3.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFRKB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFRKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFRKB Gene

Disorders for NFRKB Gene

Relevant External Links for NFRKB

Genetic Association Database (GAD)
NFRKB
Human Genome Epidemiology (HuGE) Navigator
NFRKB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFRKB

No disorders were found for NFRKB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFRKB Gene

Publications for NFRKB Gene

  1. Structure of a novel winged-helix like domain from human NFRKB protein. (PMID: 22984442) Kumar A. … Wilson I.A. (PLoS ONE 2012) 3 4 64
  2. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 46 64
  5. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PMID: 19573080) Liang X.S. … Goldin L.R. (Br. J. Haematol. 2009) 3 46 64

Products for NFRKB Gene

Sources for NFRKB Gene

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