Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NFKBIZ Gene

Aliases for NFKBIZ Gene

  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta 2 3
  • IL-1 Inducible Nuclear Ankyrin-Repeat Protein 2 3 4
  • IKBZ 3 4 6
  • INAP 3 4 6
  • MAIL 3 4 6
  • Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide 3 4
  • I-Kappa-B-Zeta 3 4
  • IkappaBzeta 3 4
  • IkB-Zeta 3 4
  • NF-Kappa-B Inhibitor Zeta 3
  • Ikappa B-Zeta Variant 3 3
  • IkappaB-Zeta 3

External Ids for NFKBIZ Gene

Summaries for NFKBIZ Gene

Entrez Gene Summary for NFKBIZ Gene

  • This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFKBIZ Gene

NFKBIZ (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and TNF-alpha/NF-kB Signaling Pathway. An important paralog of this gene is BCL3.

UniProtKB/Swiss-Prot for NFKBIZ Gene

  • Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).

Gene Wiki entry for NFKBIZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIZ Gene

Genomics for NFKBIZ Gene

Genomic Location for NFKBIZ Gene

Start:
101,827,990 bp from pter
End:
101,861,025 bp from pter
Size:
33,036 bases
Orientation:
Plus strand

Genomic View for NFKBIZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFKBIZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIZ Gene

Regulatory Elements for NFKBIZ Gene

Proteins for NFKBIZ Gene

  • Protein details for NFKBIZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYH8-IKBZ_HUMAN
    Recommended name:
    NF-kappa-B inhibitor zeta
    Protein Accession:
    Q9BYH8
    Secondary Accessions:
    • B3KNR2
    • D3DN54
    • Q8IUL4
    • Q8NAZ8

    Protein attributes for NFKBIZ Gene

    Size:
    718 amino acids
    Molecular mass:
    78061 Da
    Quaternary structure:
    • Interacts with NFKB1/p50. Interacts with RELA.

    Alternative splice isoforms for NFKBIZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBIZ Gene

Proteomics data for NFKBIZ Gene at MOPED

Post-translational modifications for NFKBIZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFKBIZ Gene

Domains for NFKBIZ Gene

Gene Families for NFKBIZ Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for NFKBIZ Gene

Suggested Antigen Peptide Sequences for NFKBIZ Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYH8

UniProtKB/Swiss-Prot:

IKBZ_HUMAN
Similarity:
  • Contains 7 ANK repeats.:
    • Q9BYH8
genes like me logo Genes that share domains with NFKBIZ: view

Function for NFKBIZ Gene

Molecular function for NFKBIZ Gene

UniProtKB/Swiss-Prot Function: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).
UniProtKB/Swiss-Prot Induction: By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 25107474
genes like me logo Genes that share ontologies with NFKBIZ: view
genes like me logo Genes that share phenotypes with NFKBIZ: view

Animal Models for NFKBIZ Gene

MGI Knock Outs for NFKBIZ:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NFKBIZ Gene

Localization for NFKBIZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIZ Gene

Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFKBIZ Gene COMPARTMENTS Subcellular localization image for NFKBIZ gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with NFKBIZ: view

Pathways for NFKBIZ Gene

genes like me logo Genes that share pathways with NFKBIZ: view

Pathways by source for NFKBIZ Gene

1 Cell Signaling Technology pathway for NFKBIZ Gene
1 BioSystems pathway for NFKBIZ Gene
1 KEGG pathway for NFKBIZ Gene

Gene Ontology (GO) - Biological Process for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with NFKBIZ: view

Transcripts for NFKBIZ Gene

Unigene Clusters for NFKBIZ Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: -
SP6:

Relevant External Links for NFKBIZ Gene

GeneLoc Exon Structure for
NFKBIZ
ECgene alternative splicing isoforms for
NFKBIZ

Expression for NFKBIZ Gene

mRNA expression in normal human tissues for NFKBIZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFKBIZ Gene

This gene is overexpressed in Fallopian Tube (4.3).

SOURCE GeneReport for Unigene cluster for NFKBIZ Gene Hs.319171

mRNA Expression by UniProt/SwissProt for NFKBIZ Gene

Q9BYH8-IKBZ_HUMAN
Tissue specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
genes like me logo Genes that share expressions with NFKBIZ: view

No data available for Protein expression for NFKBIZ Gene

Orthologs for NFKBIZ Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBIZ 35
  • 99.68 (n)
  • 99.72 (a)
NFKBIZ 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAIL 36
  • 87 (a)
OneToOne
NFKBIZ 35
  • 87.82 (n)
  • 86.97 (a)
dog
(Canis familiaris)
Mammalia MAIL 36
  • 85 (a)
OneToOne
NFKBIZ 35
  • 88.04 (n)
  • 87.5 (a)
mouse
(Mus musculus)
Mammalia Nfkbiz 35
  • 82.54 (n)
  • 81.84 (a)
Nfkbiz 16
Nfkbiz 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFKBIZ 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFKBIZ 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfkbiz 35
  • 87.66 (n)
  • 91.34 (a)
chicken
(Gallus gallus)
Aves NFKBIZ 35
  • 72.03 (n)
  • 72.41 (a)
NFKBIZ 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFKBIZ 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfkbiz 35
  • 61.23 (n)
  • 59.02 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.20590 35
nfkbiz 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C33A11.1 36
  • 16 (a)
OneToMany
Species with no ortholog for NFKBIZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFKBIZ Gene

ENSEMBL:
Gene Tree for NFKBIZ (if available)
TreeFam:
Gene Tree for NFKBIZ (if available)

Paralogs for NFKBIZ Gene

Paralogs for NFKBIZ Gene

Selected SIMAP similar genes for NFKBIZ Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFKBIZ: view

Variants for NFKBIZ Gene

Sequence variations from dbSNP and Humsavar for NFKBIZ Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14134 -- 101,857,331(-) CTGCA(A/G)GCTGG synonymous-codon, reference
rs587451 -- 101,830,283(-) AAATG(C/T)TGTAG intron-variant
rs587555 -- 101,852,706(-) GTGTA(C/T)ACAAA intron-variant
rs595788 -- 101,857,038(+) ATTTT(C/T)TTTTT intron-variant
rs599849 -- 101,857,918(-) ATAGA(C/T)AGAAA intron-variant

Relevant External Links for NFKBIZ Gene

HapMap Linkage Disequilibrium report
NFKBIZ
Human Gene Mutation Database (HGMD)
NFKBIZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NFKBIZ Gene

Disorders for NFKBIZ Gene

(1) University of Copenhagen DISEASES for NFKBIZ Gene

Relevant External Links for NFKBIZ

Genetic Association Database (GAD)
NFKBIZ
Human Genome Epidemiology (HuGE) Navigator
NFKBIZ
genes like me logo Genes that share disorders with NFKBIZ: view

No data available for UniProtKB/Swiss-Prot for NFKBIZ Gene

Publications for NFKBIZ Gene

  1. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. (PMID: 16513645) Totzke G. … Schulze-Osthoff K. (J. Biol. Chem. 2006) 2 3 4
  2. IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. (PMID: 16622025) Cowland J.B. … Borregaard N. (J. Immunol. 2006) 3 4
  3. Innate immunity of the ocular surface and ocular surface inflammatory disorders. (PMID: 18813073) Ueta M. (Cornea 2008) 3 48
  4. Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. (PMID: 11278262) Haruta H. … Todokoro K. (J. Biol. Chem. 2001) 3 23
  5. Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta. (PMID: 12565889) Eto A. … Takeshige K. (Biochem. Biophys. Res. Commun. 2003) 2 3

Products for NFKBIZ Gene

  • antibodies-online proteins for NFKBIZ
  • antibodies-online antibodies for NFKBIZ
  • antibodies-online kits for NFKBIZ

Sources for NFKBIZ Gene

Back to Top

Content