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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NFKBIZ Gene

protein-coding GIFtS: 54
GCID: GC03P101546

nuclear factor of kappa light polypeptide gene enhancer...

Explore 3 diseases affiliated with
NFKBIZ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta¹ ²		IkappaB-Zeta¹
INAP¹ ² ³ ⁵		IkB-Zeta¹
MAIL¹ ² ³ ⁵		Ikappa B-Zeta Variant 3²
IKBZ² ³ ⁵		IkappaBzeta³
Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide² ³		NF-Kappa-B Inhibitor Zeta²
I-Kappa-B-Zeta¹		IkB-Zeta¹
IL-1 Inducible Nuclear Ankyrin-Repeat Protein² ³		IkappaBzeta³
FLJ34463¹

External Ids:	HGNC: 29805¹	Entrez Gene: 64332²	Ensembl: ENSG00000144802⁷	OMIM: 608004⁵	UniProtKB: Q9BYH8³

Export aliases for NFKBIZ gene to outside databases

Previous GC identifers: GC03P103051 GC03P098915

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFKBIZ:

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion

of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family

of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B

proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I

kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8

Function: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without

affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the

NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated

transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with

NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6

promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the

induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity)

Gene Wiki entry for NFKBIZ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NFKBIZ gene promoter:
CREB C/EBPbeta Nkx2-2 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NFKBIZ promoter sequence

Search SABiosciences Chromatin IP Primers for NFKBIZ

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIZ

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p12-q12 Ensembl cytogenetic band: 3q12.3 HGNC cytogenetic band: 3p12-q12

NFKBIZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIZ gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P101546: view genomic region (about GC identifiers)

Start:	101,546,834 bp from pter	End:	101,579,869 bp from pter
Size:	33,036 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8 (See protein sequence)

Recommended Name: NF-kappa-B inhibitor zeta

Size: 718 amino acids; 78061 Da

Subunit: Interacts with NFKB1/p50. Interacts with RELA

Subcellular location: Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2

Secondary accessions: B3KNR2 D3DN54 Q8IUL4 Q8NAZ8

Alternative splicing: 3 isoforms: Q9BYH8-1 Q9BYH8-2 Q9BYH8-3

Explore the universe of human proteins at neXtProt for NFKBIZ: NX_Q9BYH8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BYH8

NFKBIZ Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001005474.1 NP_113607.1

ENSEMBL proteins:

ENSP00000418502 ENSP00000419800 ENSP00000377618 ENSP00000325593 ENSP00000325663

ENSP00000418498 ENSP00000420700

Human Recombinant Protein Products for NFKBIZ:

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

NFKBIZ for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NFKBIZ for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q9BYH8

ProtoNet protein and cluster: Q9BYH8

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8

Similarity: Contains 7 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IKBZ_HUMAN, Q9BYH8

Function: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without

affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the

NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated

transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with

NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6

promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the

induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity)

Induction: By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS)

Phenotypes:
1 GenomeRNAi human phenotype for NFKBIZ:

Decreased nuclei size in G2M

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nfkbiz):

behavior/neurological	homeostasis/metabolism	immune system	integument	mortality/aging
vision/eye

NFKBIZ for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for NFKBIZ: Nfkbiz^tm1Mamo Nfkbiz^tm1Aki

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NFKBIZ

miRNA Products:		miRTarBase miRNAs that target NFKBIZ: hsa-mir-124 (MIRT005083)

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		SwitchGear 3'UTR luciferase reporter plasmid: NFKBIZ 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIZ

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

NF-kappaB Signaling

NF-kappaB Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for NFKBIZ

NF-kappaB Signaling

1 BioSystems Pathway for NFKBIZ

TNF-alpha/NF-kB Signaling Pathway

NFKBIZ for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NFKBIZ

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for NFKBIZ (Q9BYH8³ ENSP00000325663⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838³, ENSP00000226574⁴	I2D: score=6 STRING: ENSP00000226574
NFKB2	Q00653³, ENSP00000189444⁴	I2D: score=2 STRING: ENSP00000189444
ELF5	Q9UKW6³, ENSP00000311010⁴	I2D: score=1 STRING: ENSP00000311010
STAT3	P40763³, ENSP00000264657⁴	I2D: score=1 STRING: ENSP00000264657
EHF	Q9NZC4³, ENSP00000257831⁴	I2D: score=1 STRING: ENSP00000257831

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006954	inflammatory response	IEA	--

NFKBIZ for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NFKBIZ
Search CenterWatch for drugs/clinical trials and news about NFKBIZ / IKBZ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NFKBIZ gene (2 alternative transcripts):

NM_001005474.2 NM_031419.3

Unigene Cluster for NFKBIZ:

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

Hs.319171 [show with all ESTs]

Unigene Representative Sequence: BC060800

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000461724 ENST00000483180 ENST00000394054(uc003dvo.3 uc010hpo.3)

ENST00000326151 ENST00000326172(uc003dvp.3 uc003dvq.3) ENST00000486444

ENST00000491281 ENST00000465476 ENST00000477601 ENST00000495089 ENST00000495719

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NFKBIZ Browse OriGene MicroRNA Expression Plasmids
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		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate NFKBIZ (see all 27):
		hsa-miR-607 hsa-miR-376b hsa-miR-1288 hsa-miR-522 hsa-miR-3660 hsa-let-7a-2* hsa-miR-374a hsa-miR-410

		SwitchGear 3'UTR luciferase reporter plasmid: NFKBIZ 3' UTR sequence

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Additional cDNA sequence:

AB037925.1 AB074898.1 AF548362.1 AK054787.1 AK091782.1 BC014587.2 BC060800.1 DQ224339.1

14 DOTS entries:

DT.448922 DT.95228158 DT.86854449 DT.100791436 DT.120878826 DT.100791434 DT.211417 DT.92427608

DT.91966567 DT.95075148 DT.95266831 DT.99950932 DT.99985966 DT.91693666

24/165 AceView cDNA sequences (see all 165):

AX747180 CN480831 CK429418 BX476983 AW044496 BX477621 BU784798 AF548362

AK054787 NM_031419 AI826223 BE274224 AK091782 CD723974 BU784595 AB037925

BU786322 AI889671 AI225043 CA314641 AA112069 C00721 BC060800 CA394049

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIZ (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b
SP1:			-						-																				-
SP2:			-						-																				-
SP3:									-
SP4:																													-		-
SP5:			-

ECgene alternative splicing isoforms for NFKBIZ

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NFKBIZ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGAGGAAT

About this image

NFKBIZ expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Mature Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See NFKBIZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NFKBIZ

SOURCE GeneReport for Unigene cluster: Hs.319171

UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8

Tissue specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver,

placenta, and at low levels in spleen, kidney, skeletal muscle and heart

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIZ

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NFKBIZ gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NFKBIZ¹	nuclear factor of kappa light polypeptide gene enhancer more	71.48(n) 71.8(a)		418404 NM_001006254.1 NP_001006254.1
lizard (Anolis carolinensis)	Reptilia	NFKBIZ⁶ --	--	64(a) 39(a)	1 ↔ 1 possible ortholog	3(173469341-173478408) GL343521.1(273836-280158)
zebrafish (Danio rerio)	Actinopterygii	Dr.20590²	Transcribed sequence with weak similarity to protein more	76.52(n)		57087907
worm (Caenorhabditis elegans)	Secernentea	C33A11.1⁶	--	14(a)	1 → many	X(15355167-15363795)

ENSEMBL Gene Tree for NFKBIZ (if available)
TreeFam Gene Tree for NFKBIZ (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NFKBIZ gene

NFKBID² NFKBIA² NFKBIB² NFKBIE² BCL3²

1 SIMAP similar gene for NFKBIZ using alignment to 5 protein entries: IKBZ_HUMAN (see all proteins):

NFKBID

NFKBIZ for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6795426^1,2	C,H	--	101545045(+)	`GCCTTT/CATATA`	3	--	ut3¹ us2k¹		6		NS EA NA	404
rs77274669^1,2	F	--	101545106(+)	`AAATAG/CTGATG`	3	--	us2k¹ ut3¹		1		NA	120
rs142633202^1,2		--	101545198(+)	`ATTATC/TTCTGT`	3	--	ut3¹ us2k¹		0	--	--	--	--
rs115476853^1,2	F	--	101545211(+)	`ATTCTG/AGGTAA`	3	--	us2k¹ ut3¹		1		WA	118
rs2625288^1,2	C,F,A,H	--	101545319(-)	`CTACAT/CTGTAG`	3	--	ut3¹ us2k¹		25		NS EA NA WA	2774
rs192583608^1,2		--	101545464(+)	`GTGGAC/TGATAA`	3	--	us2k¹ ut3¹		0	--	--	--	--
rs183418804^1,2		--	101545465(+)	`TGGACA/GATAAG`	3	--	us2k¹ ut3¹		0	--	--	--	--
rs622013^1,2	C,F,A,H	--	101545585(+)	`TTTTTT/AAAAAA`	3	--	us2k¹ ut3¹		13		NS EA NA WA CSA	738
rs187537009^1,2		--	101545643(+)	`GAGGCC/TGAGGT`	3	--	us2k¹ ut3¹		0	--	--	--	--
rs192812386^1,2		--	101545821(+)	`GCAGTA/GAGCCG`	3	--	ut3¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NFKBIZ (101546834 - 101579869 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NFKBIZ: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NFKBIZ for disorders           About GeneDecksing

OMIM gene information: 608004    OMIM disorders: --

3 diseases for NFKBIZ:    About MalaCards

stevens-johnson syndrome myxoid liposarcoma liposarcoma

1 disease from the University of Copenhagen DISEASES database for NFKBIZ:

Stevens-Johnson syndrome

Human Genome Epidemiology (HuGE) Navigator: NFKBIZ (2 documents)

Export disorders for NFKBIZ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NFKBIZ gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with NFKBIZ)

Utopia: connect your pdf to the dynamic
world of online information

A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. (PubMed id 16513645)^{1, 2, 3} Totzke G....Schulze-Osthoff K. (2006)
IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. (PubMed id 16622025)^{1, 2} Cowland J.B.... Borregaard N. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta. (PubMed id 12565889)^{1, 3} Eto A....Takeshige K. (2003)
Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. (PubMed id 11278262)^{1, 9} Haruta H....Todokoro K. (2001)
Identification of interleukin-1 receptor-associated ki nase 1 as a critical component that induces post-transcriptional activation of I kB-z. (PubMed id 22059479)¹ Ohba T....Muta T. (2012)
Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)¹ ....Compston A. (2011)
Legionella pneumophila-induced II_BIP-dependent express ion of interleukin-6 in lung epithelium. (PubMed id 20650996)¹ Lorenz J....Schmeck B. (2011)
II_BIP augments IL-12- and IL-18-mediated IFN-I^ product ion in human NK cells. (PubMed id 21224476)¹ Kannan Y....Wewers M.D. (2011)
NFKBIZ polymorphisms and susceptibility to pneumococc al disease in European and African populations. (PubMed id 19798075)¹ Chapman S.J....Hill A.V. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64332	HGNC: 29805	AceView: NFKBIZ	Ensembl:ENSG00000144802	euGenes: HUgn64332
ECgene: NFKBIZ	H-InvDB: NFKBIZ

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NFKBIZ	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NFKBIZ gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NFKBIZ gene:
Search GeneIP for patents involving NFKBIZ

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