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NFKBIZ Gene

protein-coding   GIFtS: 54
GCID: GC03P101546

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
Inhibitor, Zeta1 2
     IkappaB-zeta2
IL-1 Inducible Nuclear Ankyrin-Repeat Protein1 2 3     ikB-zeta2
IKBZ2 3 5     Ikappa B-Zeta Variant 32
INAP2 3 5     ikappaBzeta2
MAIL2 3 5     NF-Kappa-B Inhibitor Zeta2
Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide2 3     IkB-zeta3
I-kappa-B-zeta2 3     IkappaBzeta3

External Ids:    HGNC: 298051   Entrez Gene: 643322   Ensembl: ENSG000001448027   OMIM: 6080045   UniProtKB: Q9BYH83   

Export aliases for NFKBIZ gene to outside databases

Previous GC identifers: GC03P103051 GC03P098915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFKBIZ Gene:
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal
portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I
kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their
interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product
is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NFKBIZ Gene:
NFKBIZ (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta) is a protein-coding gene. Diseases associated with NFKBIZ include myxoid liposarcoma, and liposarcoma. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8
Function: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity
without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of
the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate
NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation
activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2
and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to
LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling.
May promote apoptosis (By similarity)

Gene Wiki entry for NFKBIZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFKBIZ gene promoter:
         CREB   C/EBPbeta   Nkx2-2   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NFKBIZ promoter sequence
   Search Chromatin IP Primers for NFKBIZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFKBIZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p12-q12   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3p12-q12

NFKBIZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIZ gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P101546:  view genomic region     (about GC identifiers)

Start:
101,546,834 bp from pter      End:
101,579,869 bp from pter
Size:
33,036 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor zeta  
Size: 718 amino acids; 78061 Da
Subunit: Interacts with NFKB1/p50. Interacts with RELA
Secondary accessions: B3KNR2 D3DN54 Q8IUL4 Q8NAZ8
Alternative splicing: 3 isoforms:  Q9BYH8-1   Q9BYH8-2   Q9BYH8-3   

Explore the universe of human proteins at neXtProt for NFKBIZ: NX_Q9BYH8

Explore proteomics data for NFKBIZ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFKBIZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005474.1  NP_113607.1  

    ENSEMBL proteins: 
     ENSP00000418502   ENSP00000419800   ENSP00000377618   ENSP00000325593   ENSP00000325663  
     ENSP00000418498   ENSP00000420700  

    NFKBIZ Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9BYH8

    ProtoNet protein and cluster: Q9BYH8

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8
    Similarity: Contains 7 ANK repeats


    NFKBIZ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKBZ_HUMAN, Q9BYH8
    Function: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity
    without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of
    the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate
    NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation
    activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2
    and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to
    LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling.
    May promote apoptosis (By similarity)
    Induction: By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    NFKBIZ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NFKBIZ:
     Decreased nuclei size in G2M 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nfkbiz):
     behavior/neurological  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  respiratory system  vision/eye 

    NFKBIZ for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NFKBIZ: Nfkbiztm1Mamo Nfkbiztm1Aki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFKBIZ
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    hsa-mir-192-5p (MIRT026903), hsa-mir-193b-3p (MIRT041268), hsa-mir-335-5p (MIRT019222), hsa-mir-124-3p (MIRT005083), hsa-mir-215-5p (MIRT024334)

    Block miRNA regulation of human, mouse, rat NFKBIZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFKBIZ (see all 27):
    hsa-miR-607 hsa-miR-376b hsa-miR-1288 hsa-miR-522 hsa-miR-3660 hsa-let-7a-2* hsa-miR-374a hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIZ 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): NFKBIZ (NM_031419)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKBZ_HUMAN, Q9BYH8: Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NFKBIZ for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NFKBIZ About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    3NF-kappaB Signaling
    NF-kappaB Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NFKBIZ
        NF-kappaB Signaling

    1 BioSystems Pathway for NFKBIZ
        TNF-alpha/NF-kB Signaling Pathway


    1 Kegg Pathway  (Kegg details for NFKBIZ):
        Transcriptional misregulation in cancer


    NFKBIZ for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NFKBIZ
    Interactions:

        GeneGlobe Interaction Network for NFKBIZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for NFKBIZ (Q9BYH83 ENSP000003256634) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198383, ENSP000002265744I2D: score=6 STRING: ENSP00000226574
    NFKB2Q006533, ENSP000001894444I2D: score=2 STRING: ENSP00000189444
    ELF5Q9UKW63, ENSP000003110104I2D: score=1 STRING: ENSP00000311010
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    EHFQ9NZC43, ENSP000002578314I2D: score=1 STRING: ENSP00000257831
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006954inflammatory response IEA--

    NFKBIZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for NFKBIZ (IKBZ)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NFKBIZ gene (2 alternative transcripts): 
    NM_001005474.2  NM_031419.3  

    Unigene Cluster for NFKBIZ:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
    Hs.319171  [show with all ESTs]
    Unigene Representative Sequence: BC060800
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461724 ENST00000483180 ENST00000394054(uc003dvo.3 uc010hpo.3)
    ENST00000326151 ENST00000326172(uc003dvp.3 uc003dvq.3) ENST00000486444
    ENST00000491281 ENST00000465476 ENST00000477601 ENST00000495089 ENST00000495719

    miRNA
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    Block miRNA regulation of human, mouse, rat NFKBIZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFKBIZ (see all 27):
    hsa-miR-607 hsa-miR-376b hsa-miR-1288 hsa-miR-522 hsa-miR-3660 hsa-let-7a-2* hsa-miR-374a hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIZ 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NFKBIZ

    Additional mRNA sequence: 

    AB037925.1 AB074898.1 AF548362.1 AK054787.1 AK091782.1 BC014587.2 BC060800.1 DQ224339.1 

    15 DOTS entries:

    DT.448922  DT.95228158  DT.86854449  DT.100791436  DT.120878826  DT.100791434  DT.211417  DT.92427608 
    DT.100791437  DT.91966567  DT.95075148  DT.95266831  DT.99950932  DT.99985966  DT.91693666 

    Selected AceView cDNA sequences (see all 165):

    CK429418 BX477621 NM_031419 BX476983 BE274224 CD723974 BU784595 CN480831 
    AI225043 H69786 AI889671 AK054787 BC060800 AA083752 AI826223 C00721 
    CA314641 AB037925 AA258425 CA394049 AA112069 AX747180 AW044496 AF548362 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIZ (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
    SP1:        -                 -                                                           -                                 
    SP2:        -                 -                                                           -                                 
    SP3:                          -                                                                                             
    SP4:                                                                                      -     -                           
    SP5:        -                                                                                                               


    ECgene alternative splicing isoforms for NFKBIZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NFKBIZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAGGAAT
    NFKBIZ Expression
    About this image


    NFKBIZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Bone (Muscoskeletal System)
             Bone Marrow
    NFKBIZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFKBIZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.319171

    UniProtKB/Swiss-Prot: IKBZ_HUMAN, Q9BYH8
    Tissue specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver,
    placenta, and at low levels in spleen, kidney, skeletal muscle and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NFKBIZ gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfkbiz1 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 82.54(n)1
    81.84(a)1
      16 (33.65 cM)5
    808591  NM_001159394.11  NP_001152866.11 
     558113755 
    chicken
    (Gallus gallus)
    Aves NFKBIZ1 nuclear factor of kappa light polypeptide gene enhancer more 72.03(n)
    72.41(a)
      418404  NM_001006254.1  NP_001006254.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFKBIZ6
    nuclear factor of kappa light polypeptide gene enh...
    65(a)
    1 ↔ 1
    3(173464646-173478410)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nfkbiz1 nuclear factor of kappa light polypeptide gene enhancer more 61.23(n)
    59.02(a)
      100170483  NM_001130266.1  NP_001123738.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.205902 Transcribed sequence with weak similarity to protein more 76.52(n)    57087907 
    worm
    (Caenorhabditis elegans)
    Secernentea C33A11.16
    Protein C33A11.1 (C33A11.1) mRNA, complete cds
    16(a)
    1 → many
    X(15355238-15363864) WBGene00007877


    ENSEMBL Gene Tree for NFKBIZ (if available)
    TreeFam Gene Tree for NFKBIZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFKBIZ gene
    NFKBID2  NFKBIB2  NFKBIA2  NFKBIE2  BCL32  
    1 SIMAP similar gene for NFKBIZ using alignment to 5 protein entries:     IKBZ_HUMAN (see all proteins):
    NFKBID

    NFKBIZ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFKBIZ (see all 625)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907853551,2
    --101547653(+) TAGAAC/TGGATT 1 -- int10--------
    rs1833327141,2
    --101547656(+) AATGGA/TTTAGA 1 -- int10--------
    rs173476441,2
    C,F--101547733(+) AGTTAC/TGTAAA 1 -- int115Minor allele frequency- T:0.33NA EA WA CSA 590
    rs1866978091,2
    --101548074(+) GGAGCA/GCTGCG 1 -- int10--------
    rs1920052081,2
    --101548094(+) TCAGTA/CTGAGA 1 -- int10--------
    rs1390553961,2
    --101548324(+) AGAGCC/TATGGA 1 -- int10--------
    rs1416232941,2
    --101548512(+) CTTGGC/TCTGAT 1 -- ut510--------
    rs38979061,2
    C,F,H--101548610(-) AAATCC/TCACTG 1 -- int111Minor allele frequency- T:0.01NS EA NA 1410
    rs3743365561,2
    C--101548721(+) GATTT-/TGTTTGT 1 -- int10--------
    rs286535921,2
    C,F--101548723(+) ATTTTG/TTGTGT 1 -- int13Minor allele frequency- T:0.33WA NA CSA 6

    HapMap Linkage Disequilibrium report for NFKBIZ (101546834 - 101579869 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NFKBIZ: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFKBIZ
    DNA2.0 Custom Variant and Variant Library Synthesis for NFKBIZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608004    OMIM disorders: --

    6 diseases for NFKBIZ:    
    About MalaCards
    myxoid liposarcoma    liposarcoma    stevens-johnson syndrome    multiple sclerosis
    neuroblastoma    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for NFKBIZ:
    Stevens-Johnson syndrome

    NFKBIZ for disorders           About GeneDecksing

    Genetic Association Database (GAD): NFKBIZ
    Human Genome Epidemiology (HuGE) Navigator: NFKBIZ (2 documents)

    Export disorders for NFKBIZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFKBIZ gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with NFKBIZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. (PubMed id 16513645)1, 2, 3 Totzke G....Schulze-Osthoff K. (J. Biol. Chem. 2006)
    2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    3. NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations. (PubMed id 19798075)1, 4 Chapman S.J....Hill A.V. (Genes Immun. 2010)
    4. Innate immunity of the ocular surface and ocular surface inflammatory disorders. (PubMed id 18813073)1, 4 Ueta M. (Cornea 2008)
    5. IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. (PubMed id 16622025)1, 2 Cowland J.B.... Borregaard N. (J. Immunol. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta. (PubMed id 12565889)1, 3 Eto A....Takeshige K. (Biochem. Biophys. Res. Commun. 2003)
    8. Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. (PubMed id 11278262)1, 9 Haruta H....Todokoro K. (J. Biol. Chem. 2001)
    9. II_B-IP controls the constitutive NF-I_B target gene network and survival of ABC DLBCL. (PubMed id 23869088)1 Nogai H....Lenz G. (Blood 2013)
    10. Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of II_B-IP. (PubMed id 22059479)1 Ohba T....Muta T. (FEBS J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64332 HGNC: 29805 AceView: NFKBIZ Ensembl:ENSG00000144802 euGenes: HUgn64332
    ECgene: NFKBIZ Kegg: 64332 H-InvDB: NFKBIZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NFKBIZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NFKBIZ gene:
    Search GeneIP for patents involving NFKBIZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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