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Aliases for NFKBIZ Gene

Aliases for NFKBIZ Gene

  • NFKB Inhibitor Zeta 2 3 5
  • IL-1 Inducible Nuclear Ankyrin-Repeat Protein 2 3 4
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Zeta 2 3
  • Molecule Possessing Ankyrin Repeats Induced By Lipopolysaccharide 3 4
  • NF-Kappa-B Inhibitor Zeta 2 3
  • I-Kappa-B-Zeta 3 4
  • IkappaBzeta 3 4
  • IkB-Zeta 3 4
  • IKBZ 3 4
  • INAP 3 4
  • MAIL 3 4
  • Ikappa B-Zeta Variant 3 3
  • IkappaB-Zeta 3

External Ids for NFKBIZ Gene

Previous GeneCards Identifiers for NFKBIZ Gene

  • GC03P103051
  • GC03P101546
  • GC03P098915

Summaries for NFKBIZ Gene

Entrez Gene Summary for NFKBIZ Gene

  • This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NFKBIZ Gene

NFKBIZ (NFKB Inhibitor Zeta) is a Protein Coding gene. Diseases associated with NFKBIZ include Myxoid Liposarcoma and Brain Glioblastoma Multiforme. Among its related pathways are Transcriptional misregulation in cancer and NF-kappaB Signaling. GO annotations related to this gene include transcription cofactor activity. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot for NFKBIZ Gene

  • Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).

Gene Wiki entry for NFKBIZ Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIZ Gene

Genomics for NFKBIZ Gene

Regulatory Elements for NFKBIZ Gene

Enhancers for NFKBIZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G101935 1.9 FANTOM5 Ensembl ENCODE dbSUPER 33 +111.2 111207 8.1 HDGF PKNOX1 FOXA2 ATF1 SIN3A FEZF1 GATA2 ELK1 CBX5 FOS NFKBIZ ZPLD1 NXPE3 SENP7 ZBTB11-AS1 ZBTB11 LINC02085 GC03M101929
GH03G101901 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.4 +74.8 74767 2.3 ATF1 INSM2 SIN3A BRCA1 ZEB1 ZNF366 FOS ETV6 CREM SP3 NFKBIZ ZPLD1 NXPE3 GC03M101929 GC03P101864
GH03G101898 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +71.2 71235 1.7 PKNOX1 TBL1XR1 BMI1 RFX5 CBX5 ZNF143 ETV6 RELB IKZF2 CREM NFKBIZ ZPLD1 ZBTB11-AS1 NXPE3 ZBTB11 GC03M101929 GC03P101864
GH03G101873 1.4 FANTOM5 Ensembl ENCODE dbSUPER 25.3 +45.8 45767 0.5 JUND JUN CEBPA FOS CEBPG PRDM1 NFKBIZ ZPLD1 GC03P101864 GC03M101929
GH03G102223 1.3 FANTOM5 Ensembl dbSUPER 22.5 +395.4 395407 0.4 PKNOX1 BACH1 BMI1 ZNF316 EED ETV6 RELB MAFK IKZF2 CREM NFKBIZ ENSG00000249474 RPL24 ZPLD1 GC03P102209 PIR36108 GC03P102210 GC03M102416
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFKBIZ on UCSC Golden Path with GeneCards custom track

Promoters for NFKBIZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000155802 10 1601 HDGF PKNOX1 ATF1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for NFKBIZ Gene

Chromosome:
3
Start:
101,827,990 bp from pter
End:
101,861,025 bp from pter
Size:
33,036 bases
Orientation:
Plus strand

Genomic View for NFKBIZ Gene

Genes around NFKBIZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBIZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBIZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIZ Gene

Proteins for NFKBIZ Gene

  • Protein details for NFKBIZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYH8-IKBZ_HUMAN
    Recommended name:
    NF-kappa-B inhibitor zeta
    Protein Accession:
    Q9BYH8
    Secondary Accessions:
    • B3KNR2
    • D3DN54
    • Q8IUL4
    • Q8NAZ8

    Protein attributes for NFKBIZ Gene

    Size:
    718 amino acids
    Molecular mass:
    78061 Da
    Quaternary structure:
    • Interacts with NFKB1/p50. Interacts with RELA.

    Alternative splice isoforms for NFKBIZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBIZ Gene

Post-translational modifications for NFKBIZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFKBIZ Gene

Domains & Families for NFKBIZ Gene

Gene Families for NFKBIZ Gene

Protein Domains for NFKBIZ Gene

Suggested Antigen Peptide Sequences for NFKBIZ Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NFKBIZ: view

No data available for UniProtKB/Swiss-Prot for NFKBIZ Gene

Function for NFKBIZ Gene

Molecular function for NFKBIZ Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).
UniProtKB/Swiss-Prot Induction:
By TNF, IL1/interleukin-1 and bacterial lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 25107474
genes like me logo Genes that share ontologies with NFKBIZ: view
genes like me logo Genes that share phenotypes with NFKBIZ: view

Animal Models for NFKBIZ Gene

MGI Knock Outs for NFKBIZ:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBIZ Gene

Localization for NFKBIZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIZ Gene

Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBIZ gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA --
GO:0005634 nucleus IBA,IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with NFKBIZ: view

Pathways & Interactions for NFKBIZ Gene

genes like me logo Genes that share pathways with NFKBIZ: view

Pathways by source for NFKBIZ Gene

1 Cell Signaling Technology pathway for NFKBIZ Gene
1 KEGG pathway for NFKBIZ Gene

Gene Ontology (GO) - Biological Process for NFKBIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with NFKBIZ: view

No data available for SIGNOR curated interactions for NFKBIZ Gene

Drugs & Compounds for NFKBIZ Gene

No Compound Related Data Available

Transcripts for NFKBIZ Gene

Unigene Clusters for NFKBIZ Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: -
SP6:

Relevant External Links for NFKBIZ Gene

GeneLoc Exon Structure for
NFKBIZ
ECgene alternative splicing isoforms for
NFKBIZ

Expression for NFKBIZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFKBIZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFKBIZ Gene

This gene is overexpressed in Fallopian Tube (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of NFKBIZ Gene:

NFKBIZ

SOURCE GeneReport for Unigene cluster for NFKBIZ Gene:

Hs.319171

mRNA Expression by UniProt/SwissProt for NFKBIZ Gene:

Q9BYH8-IKBZ_HUMAN
Tissue specificity: Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for NFKBIZ Gene

  • Nervous system(4.6)
  • Lung(4.5)
  • Blood(4.4)
  • Spleen(2.3)
  • Bone marrow(2.2)
  • Intestine(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with NFKBIZ: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKBIZ Gene

Orthologs for NFKBIZ Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBIZ 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia NFKBIZ 34
  • 88.04 (n)
MAIL 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFKBIZ 34
  • 87.82 (n)
MAIL 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfkbiz 34
  • 87.66 (n)
mouse
(Mus musculus)
Mammalia Nfkbiz 34 16 35
  • 82.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFKBIZ 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFKBIZ 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFKBIZ 34 35
  • 72.03 (n)
lizard
(Anolis carolinensis)
Reptilia NFKBIZ 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfkbiz 34
  • 61.23 (n)
zebrafish
(Danio rerio)
Actinopterygii nfkbiz 35
  • 50 (a)
OneToOne
Dr.20590 34
worm
(Caenorhabditis elegans)
Secernentea C33A11.1 35
  • 16 (a)
OneToMany
Species where no ortholog for NFKBIZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFKBIZ Gene

ENSEMBL:
Gene Tree for NFKBIZ (if available)
TreeFam:
Gene Tree for NFKBIZ (if available)

Paralogs for NFKBIZ Gene

Paralogs for NFKBIZ Gene

(1) SIMAP similar genes for NFKBIZ Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFKBIZ: view

Variants for NFKBIZ Gene

Sequence variations from dbSNP and Humsavar for NFKBIZ Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000263983 -- 101,853,551(+) AGTTT(C/T)CCTTC reference, missense
rs1000389583 -- 101,826,707(+) AACTT(A/G)TCTCT upstream-variant-2KB, utr-variant-3-prime
rs1000415953 -- 101,860,602(+) ACATA(C/T)CTTCC utr-variant-3-prime
rs1000464754 -- 101,858,868(+) GAATG(C/G)TATTA intron-variant
rs1000470538 -- 101,860,324(+) CAGGT(A/G)TGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NFKBIZ Gene

Variant ID Type Subtype PubMed ID
nsv953238 CNV duplication 24416366

Variation tolerance for NFKBIZ Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFKBIZ Gene

Human Gene Mutation Database (HGMD)
NFKBIZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFKBIZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIZ Gene

Disorders for NFKBIZ Gene

MalaCards: The human disease database

(3) MalaCards diseases for NFKBIZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myxoid liposarcoma
  • mrcls
brain glioblastoma multiforme
  • brain glioblastoma
hypersensitivity syndrome, carbamazepine-induced
  • toxic epidermal necrolysis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NFKBIZ

Genetic Association Database (GAD)
NFKBIZ
Human Genome Epidemiology (HuGE) Navigator
NFKBIZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFKBIZ
genes like me logo Genes that share disorders with NFKBIZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFKBIZ Gene

Publications for NFKBIZ Gene

  1. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. (PMID: 16513645) Totzke G. … Schulze-Osthoff K. (J. Biol. Chem. 2006) 2 3 4 64
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  3. NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations. (PMID: 19798075) Chapman S.J. … Hill A.V. (Genes Immun. 2010) 3 46 64
  4. Innate immunity of the ocular surface and ocular surface inflammatory disorders. (PMID: 18813073) Ueta M. (Cornea 2008) 3 46 64
  5. IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta. (PMID: 16622025) Cowland J.B. … Borregaard N. (J. Immunol. 2006) 3 4 64

Products for NFKBIZ Gene

Sources for NFKBIZ Gene

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