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NFKBIL1 Gene

protein-coding   GIFtS: 52
GCID: GC06P031514

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...


(Previous symbol: NFKBIL)
  See NFKBIL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
Inhibitor-Like 11 2 3
     LST12
NFKBIL1 2     ikappaBL2
Inhibitor Of Kappa B-Like Protein2 3     NF-Kappa-B Inhibitor-Like Protein 12
IKBL2 3     IkappaBL3
I-Kappa-B-Like Protein2 3     

External Ids:    HGNC: 78001   Entrez Gene: 47952   Ensembl: ENSG000002044987   OMIM: 6010225   UniProtKB: Q9UBC13   

Export aliases for NFKBIL1 gene to outside databases

Previous GC identifers: GC06P031578 GC06P031285 GC06P031619 GC06P031623


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFKBIL1 Gene:
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined.
The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for NFKBIL1 Gene:
NFKBIL1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) is a protein-coding gene. Diseases associated with NFKBIL1 include chronic thromboembolic pulmonary hypertension, and chronic venous leg ulcers.

UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor
and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of
transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli

Gene Wiki entry for NFKBIL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFKBIL1 gene promoter:
         HOXA5   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFKBIL1 promoter sequence
   Search Chromatin IP Primers for NFKBIL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFKBIL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

NFKBIL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031514:  view genomic region     (about GC identifiers)

Start:
31,514,628 bp from pter      End:
31,526,606 bp from pter
Size:
11,979 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167245 2,800,202-2,812,171      Chr6+,NT_167248 2,808,299-2,820,269      Chr6+,NT_167246 2,857,520-2,869,496     
Chr6+,NT_113891.2 3,024,283-3,036,248      Chr6+,NT_167247 2,894,371-2,906,339      Chr6+,NT_167249 2,845,433-2,857,408     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor-like protein 1  
Size: 381 amino acids; 43204 Da
Subunit: Interacts with CACTIN (via N-terminus domain); the interaction occurs in a proinflammatory-independent
manner
Sequence caution: Sequence=BAG62473.1; Type=Erroneous termination; Positions=255; Note=Translated as Glu;
Secondary accessions: A6NL91 B4DUW1 Q14625 Q5HYU4 Q5RJ72 Q5ST96 Q5STV4 Q5STV5 Q9UBX4
Alternative splicing: 3 isoforms:  Q9UBC1-1   Q9UBC1-2   Q9UBC1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFKBIL1: NX_Q9UBC1

Explore proteomics data for NFKBIL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFKBIL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138433.1  NP_001138434.1  NP_001138435.1  NP_004998.3  

    ENSEMBL proteins: 
     ENSP00000365316   ENSP00000365318   ENSP00000365315   ENSP00000437148  

    NFKBIL1 Human Recombinant Protein Products:

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    antibodies-online peptides for NFKBIL1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBC1

    ProtoNet protein and cluster: Q9UBC1

    UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
    Similarity: Contains 2 ANK repeats


    Find genes that share domains with NFKBIL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKBL1_HUMAN, Q9UBC1
    Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor
    and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of
    transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli

         Genatlas biochemistry entry for NFKBIL1:
    nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor ar,like
    1,sequestering it in the cytoplasm,also inhibiting NF-kappa B DNA binding

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with NFKBIL1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Nfkbil1 (no phenotypes)

    Find genes that share phenotypes with NFKBIL1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NFKBIL1

    miRNA
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    miRTarBase miRNAs that target NFKBIL1:
    hsa-mir-93-3p (MIRT038896)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKBL1_HUMAN, Q9UBC1: Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells.
    Colocalizes with CACTIN in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol IEA--
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with NFKBIL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NFKBIL1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFKBIL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for NFKBIL1 (Q9UBC13 ENSP000003653184) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000233813Q9Y6763, ENSP000003984944I2D: score=2 STRING: ENSP00000398494
    ENSG00000203624Q9Y6763I2D: score=2 
    ENSG00000223775Q9Y6763I2D: score=2 
    ENSG00000226111Q9Y6763I2D: score=2 
    ENSG00000227420Q9Y6763I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007249I-kappaB kinase/NF-kappaB signaling IEA--
    GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway IDA--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA--
    GO:0032720negative regulation of tumor necrosis factor production IMP--
    GO:0034122negative regulation of toll-like receptor signaling pathway IDA--

    Find genes that share ontologies with NFKBIL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFKBIL1 (IKBL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NFKBIL1 gene (4 alternative transcripts): 
    NM_001144961.1  NM_001144962.1  NM_001144963.1  NM_005007.3  

    Unigene Cluster for NFKBIL1:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
    Hs.2764  [show with all ESTs]
    Unigene Representative Sequence: BM559803
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376146(uc011dnr.2 uc011dns.2 uc011dnt.1) ENST00000376148(uc003nuc.3 uc003nub.3)
    ENST00000376145 ENST00000496233 ENST00000473655
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      QuantiTect SYBR Green Assays in human, mouse, rat NFKBIL1
      QuantiFast Probe-based Assays in human, mouse, rat NFKBIL1

    Additional mRNA sequence: 

    AF097419.1 AF097420.1 AF097421.1 AF097422.1 AF097423.1 AF097424.1 AF097425.1 AF097426.1 
    AF097427.1 AF097428.1 AF097429.1 AK291893.1 AK300818.1 AK313888.1 BC105064.1 BC105068.1 
    BC143671.1 X77909.1 

    6 DOTS entries:

    DT.406878  DT.121310213  DT.100025757  DT.100703797  DT.86849562  DT.95101746 

    Selected AceView cDNA sequences (see all 116):

    AU099198 BM670546 AF097421 AU104697 AF097420 BE501839 AI439090 AF097419 
    BM708717 AF097423 CR601219 AW386957 BU731909 AF097422 AF097429 CR624850 
    AI359441 AA603457 AU143330 AI925883 CR593167 CR590712 AF097424 BM783544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NFKBIL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGGCCCT
    NFKBIL1 Expression
    About this image

    NFKBIL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFKBIL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2764

    UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
    Tissue specificity: Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including NFKBIL1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NFKBIL1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfkbil11 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 88.51(n)1
    92.37(a)1
      17 (18.60 cM)5
    180381  NM_010909.41  NP_035039.11 
     352201755 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    43(a)
    43(a)
    1 ↔ many
    1 ↔ many
    2(195780266-195786107)
    AAWZ02040396(79-5482)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nfkbil11 nuclear factor of kappa light polypeptide gene enhancer more 46.02(n)
    38.97(a)
      100038228  XM_004916917.1  XP_004916974.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018871101 NF-kappa-B inhibitor-like protein 1-like 48.59(n)
    37.88(a)
      101887110  XM_005155451.1  XP_005155508.1 


    ENSEMBL Gene Tree for NFKBIL1 (if available)
    TreeFam Gene Tree for NFKBIL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFKBIL1 (see all 412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126617691,2
    H--31308932(+) aaaaaA/Gaaaaa 4 -- int1 trp30--------
    rs20715941,2
    C,F,A,H--31429675(-) TAGCAC/GAGTTC 2 -- us2k123Minor allele frequency- G:0.43NS EA NA WA CSA 2488
    rs1453289061,2
    --31429717(+) CAACCC/TTCACA 2 -- us2k10--------
    rs1425109321,2
    --31429736(+) ATTATC/TATCAT 2 -- us2k10--------
    rs20715931,2
    C,F,H--31429754(-) CTCCTC/TTGTGA 2 -- us2k128Minor allele frequency- T:0.12EA NA NS WA 4398
    rs1828987301,2
    --31429769(+) TCGAGC/GCTACC 2 -- us2k10--------
    rs455293391,2
    C,F--31429891(+) TATTAC/TAAATT 2 -- us2k11Minor allele frequency- T:0.06NA 120
    rs1163391191,2
    C,F--31429998(+) TAAGTG/ATCACA 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1469092861,2
    C--31430106(+) GGAGGC/GAACTG 2 -- us2k10--------
    rs1465795491,2
    C--31430154(+) AATCCG/AGTAGT 2 -- us2k11Minor allele frequency- A:0.00NA 4510

    HapMap Linkage Disequilibrium report for NFKBIL1 (31514628 - 31526606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NFKBIL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    nsv884417CNV Loss21882294
    nsv470809CNV Loss18288195
    nsv884418CNV Gain21882294
    esv690CNV CNV17122850
    essv13266CNV CNV17122850

    Human Gene Mutation Database (HGMD): NFKBIL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFKBIL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NFKBIL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601022   
    OMIM disorders: 180300  
    UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex
    genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial
    membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal
    tissues, and by atrophy and rarefaction of bony structures. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 5 diseases for NFKBIL1:    
    About MalaCards
    chronic thromboembolic pulmonary hypertension    chronic venous leg ulcers    rheumatoid arthritis    autoimmune pancreatitis
    juvenile rheumatoid arthritis


    Find genes that share disorders with NFKBIL1           About GenesLikeMe

    Genetic Association Database (GAD): NFKBIL1
    Human Genome Epidemiology (HuGE) Navigator: NFKBIL1 (36 documents)

    Export disorders for NFKBIL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFKBIL1 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with NFKBIL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins. (PubMed id 8081366)1, 2, 3 Albertella M.R. and Campbell D.R. (Hum. Mol. Genet. 1994)
    2. IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese. (PubMed id 14989711)1, 4, 9 Yamashita T....Yoshimatsu H. (Tissue Antigens 2004)
    3. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (PubMed id 19165231)1, 4, 9 Kominami S....Kimura A. (J. Hum. Genet. 2009)
    4. Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. (PubMed id 19578685)1, 4, 9 Cordeiro Q....Hounie A.G. (Rev Bras Psiquiatr 2009)
    5. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. (PubMed id 15969671)1, 4, 9 Migita O....Arinami T. (Clin. Exp. Allergy 2005)
    6. Characterization of tumor necrosis factor-I+ block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. (PubMed id 20854863)1, 4 Tan J.H....Wallace H.J. (Hum. Immunol. 2010)
    7. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. [Association study between exon 4 NFKBIL1 polymorphism and multiple sclerosis]. (PubMed id 20568399)1, 4 Owecki M.K....Kozubski W. (Pol. Merkur. Lekarski 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4795 HGNC: 7800 AceView: NFKBIL1 Ensembl:ENSG00000204498 euGenes: HUgn4795
    ECgene: NFKBIL1 H-InvDB: NFKBIL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NFKBIL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFKBIL1 gene:
    Search GeneIP for patents involving NFKBIL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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