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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFKBIL1 Gene

protein-coding   GIFtS: 51
GCID: GC06P031514

nuclear factor of kappa light polypeptide gene enhancer...


(Previous symbol: NFKBIL)
 Explore 28 diseases affiliated with
NFKBIL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NFKBIL1    

Aliases
for NFKBIL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
Inhibitor-Like 11 2 3
     LST12
IKBL1 2 3     IkappaBL3
NFKBIL1 2     NF-Kappa-B Inhibitor-Like Protein 12
Inhibitor Of Kappa B-Like Protein2 3     IkappaBL3
I-Kappa-B-Like Protein2 3     

External Ids:    HGNC: 78001   Entrez Gene: 47952   Ensembl: ENSG000002044987   OMIM: 6010225   UniProtKB: Q9UBC13   

Export aliases for NFKBIL1 gene to outside databases

Previous GC identifers: GC06P031578 GC06P031285 GC06P031619 GC06P031623


Summaries
for NFKBIL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NFKBIL1:
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The
gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and
interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional
activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli

Gene Wiki entry for NFKBIL1


Genomic Views
for NFKBIL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFKBIL1 gene promoter:
         HOXA5   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NFKBIL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NFKBIL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

NFKBIL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031514:  view genomic region     (about GC identifiers)

Start:
 31,514,628 bp from pter      End:
 31,526,606 bp from pter
Size:
 11,979 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_3 31,496,824-31,519,812      Chr6+,ALT_REF_LOCI_6 31,504,921-31,552,453      Chr6+,ALT_REF_LOCI_4 31,477,179-31,489,155     
Chr6+,ALT_REF_LOCI_2 31,502,098-31,553,232      Chr6+,ALT_REF_LOCI_5 31,505,794-31,517,762      Chr6+,ALT_REF_LOCI_7 31,434,898-31,446,873     

Proteins
for NFKBIL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor-like protein 1  
Size: 381 amino acids; 43204 Da
Subunit: Interacts with CACTIN (via N-terminus domain); the interaction occurs in a proinflammatory-independent manner
Subcellular location: Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes
with CACTIN in the nucleus
Sequence caution: Sequence=BAG62473.1; Type=Erroneous termination; Positions=255; Note=Translated as Glu;
Secondary accessions: A6NL91 B4DUW1 Q14625 Q5HYU4 Q5RJ72 Q5ST96 Q5STV4 Q5STV5 Q9UBX4
Alternative splicing: 3 isoforms:  Q9UBC1-1   Q9UBC1-2   Q9UBC1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFKBIL1: NX_Q9UBC1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBC1

    • NFKBIL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138433.1  NP_001138434.1  NP_001138435.1  NP_004998.3  

    ENSEMBL proteins: 
     ENSP00000365316   ENSP00000365318   ENSP00000365315   ENSP00000437148  

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    Novus Biologicals NFKBIL1 Lysate
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    Uscn Proteins for NFKBIL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005829cytosol IEA--


    NFKBIL1 for ontologies           About GeneDecksing



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    Uscn Antibodies for NFKBIL1
    ThermoFisher Antibodies for NFKBIL1

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    Uscn ELISAs and CLIAs for NFKBIL1

    Protein Domains /
    Families
    for NFKBIL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NFKBIL1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9UBC1

    ProtoNet protein and cluster: Q9UBC1

    UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
    Similarity: Contains 2 ANK repeats


    Function
    for NFKBIL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
    Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and
    interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional
    activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli

         Genatlas biochemistry entry for NFKBIL1:
    nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor ar,like
    1,sequestering it in the cytoplasm,also inhibiting NF-kappa B DNA binding

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for NFKBIL1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIL1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    NFKBIL1 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Nfkbil1 (no phenotypes)

    NFKBIL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NFKBIL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFKBIL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/17 Interacting proteins for NFKBIL1 (Q9UBC13 ENSP000003653184) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CXorf56Q9H5V93, ENSP000003606524I2D: score=2 STRING: ENSP00000360652
    GEMIN4P576783, ENSP000003217064I2D: score=2 STRING: ENSP00000321706
    MRPL44Q9H9J23, ENSP000002583834I2D: score=2 STRING: ENSP00000258383
    MRPS22P826503, ENSP000003107854I2D: score=2 STRING: ENSP00000310785
    MRPS34P829303, ENSP000003805314I2D: score=2 STRING: ENSP00000380531
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007249I-kappaB kinase/NF-kappaB cascade IEA--
    GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway IDA--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA--
    GO:0032720negative regulation of tumor necrosis factor production IMP--
    GO:0034122negative regulation of toll-like receptor signaling pathway IDA--


    NFKBIL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NFKBIL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFKBIL1
    Search CenterWatch for drugs/clinical trials and news about NFKBIL1 / IKBL1 

    Transcripts
    for NFKBIL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NFKBIL1 gene (4 alternative transcripts): 
    NM_001144961.1  NM_001144962.1  NM_001144963.1  NM_005007.3  

    Unigene Cluster for NFKBIL1:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
    Hs.2764  [show with all ESTs]
    Unigene Representative Sequence: BM559803
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376146(uc011dnr.2 uc011dns.2 uc011dnt.1) ENST00000376148(uc003nuc.3 uc003nub.3)
    ENST00000376145 ENST00000496233 ENST00000473655

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFKBIL1 (see all 7)
    OriGene shRNA RFP: NFKBIL1
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFKBIL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFKBIL1

    Additional cDNA sequence: 

    AF097419.1 AF097420.1 AF097421.1 AF097422.1 AF097423.1 AF097424.1 AF097425.1 AF097426.1 
    AF097427.1 AF097428.1 AF097429.1 AK291893.1 AK300818.1 AK313888.1 BC105064.1 BC105068.1 
    BC143671.1 X77909.1 

    6 DOTS entries:

    DT.406878  DT.121310213  DT.100025757  DT.100703797  DT.86849562  DT.95101746 

    24/116 AceView cDNA sequences (see all 116):

    AA603457 AF097420 BM670546 BU731909 BM700433 AF097429 AI925883 CR624850 
    BE501839 NM_005007 CR590712 BM783544 AF097419 AI359441 AF097424 AF097421 
    CR601219 BM708717 AF097422 AU143330 AI439090 AW386957 AF097423 AU104697 

    GeneLoc Exon Structure


    Expression
    for NFKBIL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFKBIL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAGGCCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NFKBIL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFKBIL1

    SOURCE GeneReport for Unigene cluster: Hs.2764

    UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
    Tissue specificity: Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes

        SABiosciences Expression via Pathway-Focused PCR Array including NFKBIL1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for NFKBIL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NFKBIL1 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nfkbil11 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 88.51(n)1
    92.37(a)1    		   17 (18.60 cM)5
    180381  NM_010909.41  NP_035039.11 
     352201755 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 45(a)
    44(a)
    		 many → 1
    many → 1
    		 2(195781069-195786040)
    AAWZ02040396(272-5308)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX664706.16
    		 --
    		 34(a)
    		 1 ↔ 1
    		 10(7065847-7070301)


    ENSEMBL Gene Tree for NFKBIL1 (if available)
    TreeFam Gene Tree for NFKBIL1 (if available) 

    Paralogs
    for NFKBIL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NFKBIL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/272 NCBI SNPs in NFKBIL1 are shown (see all 272)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs92674891,2
    		C,--31303825(+) caatgG/Ttgcga 4 -- int10--------
    rs92674901,2
    		C,F,H,--31304062(+) CACCTG/CGCCTT 4 -- int15Minor allele frequency- C:0.02NS EA WA 512
    rs93940751,2
    		C,H--31304318(+) ATATAG/CAGTGA 4 -- int14Minor allele frequency- C:0.00NS EA 416
    rs25163841,2
    		C,H--31304433(-) TGGCCT/CCCACC 4 -- int14Minor allele frequency- C:0.00NS EA 420
    rs77383801,2
    		C,F,A,H,--31304752(+) TTTATA/GGGTAG 4 -- int19Minor allele frequency- G:0.01NS NA 1542
    rs28444921,2
    		C,F,H,--31304906(-) AGTTTT/CGGGGG 4 -- int11Minor allele frequency- C:0.03NS 226
    rs785328291,2
    		C,--31304914(+) ACTCCC/GCCAAA 4 -- int12Minor allele frequency- G:0.09WA 120
    rs1129501501,2
    		C,--31305322(+) CCTCAG/ACCTCC 4 -- int11Minor allele frequency- A:0.50NA 2
    rs1134881021,2
    		C,--31305669(+) CCTAGG/TAGCTG 4 -- int11Minor allele frequency- T:0.50NA 2
    rs25234991,2
    		C,--31306132(-) GACTCA/C/TGTCTC 4 -- int11CSA 2

    HapMap Linkage Disequilibrium report for NFKBIL1 (31514628 - 31526606 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NFKBIL1
         1 CNV: 2625
    Human Gene Mutation Database (HGMD): NFKBIL1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NFKBIL1

    Disorders / Diseases
    for NFKBIL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NFKBIL1 for disorders           About GeneDecksing

    OMIM gene information: 601022   
    OMIM disorders: 180300  
    UniProtKB/Swiss-Prot: IKBL1_HUMAN, Q9UBC1
  • Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic
    • inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is
    characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid
    degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures

    20/28 diseases for NFKBIL1 (see all 28):    About MalaCards
    obsessive-compulsive disorder    chronic venous leg ulcers    deep vein thrombosis    rheumatoid arthritis
    juvenile rheumatoid arthritis    systemic lupus erythematosus    lupus erythematosus    dilated cardiomyopathy
    ulcerative colitis    myocardial infarction    sjogren's syndrome    cardiomyopathy
    arthritis    thrombosis    graves' disease    pulmonary hypertension
    autoimmune pancreatitis    autoimmune hepatitis    multiple sclerosis    hepatitis c

    Genetic Association Database (GAD): NFKBIL1
    Human Genome Epidemiology (HuGE) Navigator: NFKBIL1 (36 documents)

    Export disorders for NFKBIL1 gene to outside databases

    Publications
    for NFKBIL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFKBIL1 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with NFKBIL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins. (PubMed id 8081366)1, 2, 3 Albertella M.R. and Campbell D.R. (1994)
    2. IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese. (PubMed id 14989711)1, 4, 9 Yamashita T....Yoshimatsu H. (2004)
    3. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. (PubMed id 15969671)1, 4, 9 Migita O....Arinami T. (2005)
    4. TaqMan assays for genotyping of single nucleotide polymorphisms present at a disease susceptibility locus on chromosome 6. (PubMed id 15843211)1, 4 Koch W....Kastrati A. (2005)
    5. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. (PubMed id 16101831)1, 4 Shichi D....Inoko H. (2005)
    6. Complex genetic predisposition in adult and juvenile rheumatoid arthritis. (PubMed id 15018649)1, 4 Miterski B....Epplen J.T. (2004)
    7. Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. (PubMed id 12509789)1, 2 Okamoto K.... Inoko H. (2003)
    8. Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study. (PubMed id 12618859)1, 4 Martinez A....de la Concha E.G. (2003)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    10. Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL. (PubMed id 11113070)1, 4 de la Concha E.G....Diaz-Rubio M. (2000)

    External Searches for NFKBIL1 gene

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    Genome Databases showing NFKBIL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4795 HGNC: 7800 AceView: NFKBIL1 Ensembl:ENSG00000204498 euGenes: HUgn4795
    ECgene: NFKBIL1 H-InvDB: NFKBIL1

    Other Databases showing NFKBIL1 gene

    (According to HUGE)
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    Specialized Databases showing NFKBIL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFKBIL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NFKBIL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFKBIL1 gene:
    Search GeneIP for patents involving NFKBIL1

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