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NFKBIE Gene

protein-coding GIFtS: 65

GC06M044334

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
I-kappa-B-epsilon ^³
IKBE ^¹, ², ³
IkB-E ^³
IkB-epsilon ^³
IkappaBepsilon ^³
NF-kappa-BIE ^³
OTTHUMP00000016522 ^²

Descriptions
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon ^²

External Ids
HGNC: 7799¹
Entrez Gene: 4794²
UniProtKB: O00221³
Ensembl: ENSG00000146232⁷

Search outside databases for aliases for NFKBIE gene

Previous GC identifers: GC06M044224 GC06M044273

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for NFKBIE:

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB

(MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins

(NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the

cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM

600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby

allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the

nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime

HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

For some genes, activation requires NFKB interaction with other transcription factors, such as

STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).[supplied

by OMIM]

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits

DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes

Gene Wiki entry for NFKBIE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NFKBIE gene

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

NFKBIE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M044334: (about GC identifiers)

Start:	44,333,881 bp from pter
End:	44,341,503 bp from pter
Size:	7,623 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221 (See protein sequence)

Recommended Name: NF-kappa-B inhibitor epsilon

Size: 500 amino acids; 52864 Da

Subunit: Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear

factor NF-kappa-B p52 subunit

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351;

Secondary accessions: Q5T9V9

Post-translational modifications:

Serine phosphorylated; followed by proteasome-dependent degradation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004547.2

ENSEMBL proteins:

ENSP00000275015

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant NFKBIE Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IKB epsilon)
	Human Recombinant Proteins from Abnova (NFKBIE)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9135156

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Antibodies for NFKBIE:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NFKBIE
	R&D Systems Antibodies for NFKBIE (IkB-epsilon)
	Cell Signaling Technology (CST) Antibodies for NFKBIE (IkBe)
	Antibodies from Abcam (IKB epsilon), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NFKBIE)
	Novus Biologicals Antibodies for NFKBIE

Assays for NFKBIE:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O00221

ProtoNet protein and cluster: O00221

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Similarity: Belongs to the NF-kappa-B inhibitor family

Similarity: Contains 6 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NFKBIE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NFKBIE)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004556

Applied Biosystems Silencer® siRNAs for NFKBIE

Sigma-Aldrich siRNA for NFKBIE

Sigma-Aldrich shRNA for NFKBIE

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004556
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004556
untagged cDNA clones in CMV expression vector (see all 2): NM_004556

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004556

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits

DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nfkbie):

hematopoietic system

immune system

lethality-prenatal/perinatal

skeleton

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16769727

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/38 Sigma-Aldrich "Your Favorite Gene" Pathways for NFKBIE (Your Favorite Gene powered by Ingenuity) (see all 38 )

Relaxin Signaling
Role of PKR in Interferon Induction and Antiviral Response
iCOS-iCOSL Signaling in T Helper Cells
Role of RIG1-like Receptors in Antiviral Innate Immunity
Small Cell Lung Cancer Signaling

GeneDecks NFKBIE for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for NFKBIE

5/28 Interacting proteins for NFKBIE (ENSP00000275015³ O00221^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838²	STRING (score=.959) MINT-47886 MINT-48536 MINT-47905 MINT-48647
NFKB2	Q00653²	STRING (score=.949) MINT-47947 MINT-48708
RELA	Q04206²	STRING (score=.996) MINT-48905 MINT-47949
CHUK	O15111²	STRING (score=.986) MINT-47878
PPP6C	O00743²	STRING (score=.95) MINT-47948

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042994	cytoplasmic sequestering of transcription factor	TAS	9135156

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for NFKBIE

Browse Small Molecules at Sigma-Aldrich

Compounds for NFKBIE available from Tocris Bioscience

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NFKBIE)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NFKBIE)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004556

Sigma-Aldrich siRNA for NFKBIE

Sigma-Aldrich shRNA for NFKBIE

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004556

REFSEQ mRNAs for NFKBIE gene:

NM_004556.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004556

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004556
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004556
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004556

Additional cDNA sequence:

AK301360.1 BC011676.2 BC063609.1 CR599256.1 CR611091.1 CR616372.1 CR625145.1 U91616.1

7 DOTS entries:

DT.414540 DT.97861805 DT.100775152 DT.100775155 DT.100775245 DT.100775157 DT.91738521

24/521 AceView cDNA sequences (see all 521 ):

BU163977 AI073831 AA953975 Z42389 BM711990 CB113770 BU538684 AI281434

BU632152 BU552435 BU193320 BM798084 AB106538 BQ689189 CF529202 NM_178148

CR599256 BQ898825 BM451910 BM982998 BE514895 BE304877 BG763363 BE891334

highest scoring ESTs for NFKBIE:

U91616 AA160822 AW732496 BC011676 BC063609 BE384483 BE896532 BE903071 BE910232 BF568202

Unigene Cluster for NFKBIE:

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Hs.458276 [show with all ESTs]

Unigene Representative Sequence: NM_004556

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIE

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b
SP1:
SP2:
SP3:					-

About this scheme

ECgene alternative splicing isoforms for NFKBIE

1 Ensembl transcript including schematic representation:

ENST00000275015

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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NFKBIE expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NFKBIE

¹ / ² / ³

4 probe-sets matching NFKBIE gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38276_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.75	U91616	1.00	1.00	1.00	1
53701_at²^{, 3}	U95-C	1	1.00	1.00	0.66	1.26	AI568732	0.60	1.00	0.82	1
203927_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004556	0.60	1.00	0.82	1
203927_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NFKBIE for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACACTAAAAT

SOURCE GeneReport for Unigene cluster: Hs.458276
Expression variation in blood from EXPOLDB for NFKBIE
UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221
Tissue specificity: Highly expressed in spleen, testis and lung, followed by kidney, pancreas,
heart, placenta and brain. Also expressed in granulocytes and macrophages

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NFKBIE gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NFKBIE¹	--	nuclear factor of kappa light polypeptide gene enhancer more	84.79(n) 83.33(a)	609647 XM_846946.1 XP_852039.1
chimpanzee (Pan troglodytes)	NFKBIE¹	--	nuclear factor of kappa light polypeptide gene enhancer more	99.33(n) 99.2(a)	462730 XM_518507.2 XP_518507.2
cow (Bos taurus)	NFKBIE¹	--	nuclear factor of kappa light polypeptide gene enhancer more	79.69(n) 77.9(a)	506727 XM_583214.3 XP_583214.3
rat (Rattus norvegicus)	Nfkbie¹	--	nuclear factor of kappa light polypeptide gene enhancer more	82.27(n) 81.44(a)	316241 NM_199111.1 NP_954542.1
mouse (Mus musculus)	Nfkbie^{1, 5}	17⁵	nuclear factor of kappa light polypeptide gene enhancer more^{1, 5}	82.41(n)¹ 83.06(a)¹	18037¹ NM_008690.3¹ NP_032716.2¹ AA673960⁵ AF030896⁵ (see all 11)

About this table Species with no ortholog for NFKBIE

ENSEMBL Gene Tree for NFKBIE

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NFKBIE gene

NFKBIB² NFKBIA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/81 NCBI SNPs in NFKBIE are shown (see all 81 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 113)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2233434^1,2	A,C,F,H	44340898(-)	`ACCCGT/CCAAGG`	1	A/V	mis¹ ese³		9	EU EA WA NA	898
--	rs28362856^1,2	C,F	44342517(-)	`CCTTGC/GGGATA`	1	--	ng3¹		8	NS	756
	rs28362854^1,2	F	44342700(-)	`ACAACG/ATCAGA`	1	--	ng3¹		2	NS	92
	rs28362855^1,2	F	44342599(-)	`GGCCTC/ACCCCC`	1	--	ng3¹ trp³		2	NS	92
	rs28362857^1,2	F	44341194(-)	`CCCCAC/GAGCCC`	1	H/Q	mis¹ ese³		2	NS	84
	rs2233433^1,2	C	44340955(-)	`GGCTCC/TAGCCT`	1	P/L	mis¹ ese³		1	NA	64
	rs730775^1,2	A,C,F,H	44340052(+)	`GAGTGA/GGACAC`	1	--	int¹		22	NA EA EU WA NS MN CSAM	3376
	rs2233437^1,2	A,C,F	44336140(-)	`CTGCCC/TGGCCC`	1	--	int¹		2	NS	82
	rs10081001^1,2	C,F,H	44335308(+)	`GGGGGG/ACTGCT`	1	--	int¹		6	EU EA WA NS	498
	rs3799962^1,2	A,C,F	44336430(+)	`AAAGGA/GACTCA`	1	--	int¹ trp³		2	NS	92

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HapMap Linkage Disequilibrium images for NFKBIE (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604548

Human Genome Epidemiology Navigator: NFKBIE (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/25 PubMed articles for NFKBIE gene (see all 25 ):

IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity. (PubMed id 9135156)^{2, 3, 4} Whiteside S.T.... Israel A. (1997)
A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)^{3, 4} Li Z. and Nabel G.J. (1997)
IkappaB genetic polymorphisms and invasive pneumococcal disease. (PubMed id 17463416)^{1, 3} Chapman S.J....Hill A.V. (2007)
Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. (PubMed id 14595753)^{1, 3} Emmerich F....Dorken B. (2003)
Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)^{1, 3} Dieguez-Gonzalez R....Gonzalez A. (2008)
Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. (PubMed id 17976673)³ Komissarova E.V....Rossman T.G. (2008)
Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)³ Velez D.R....Menon R. (2008)
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)³ Hosgood H.D....Lan Q. (2008)
Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)³ Velez D.R....Menon R. (2008)
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PubMed id 16769727)³ Stefansson B. and Brautigan D.L. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4794	HGNC: 7799	AceView: NFKBIEandSLC35B2	Ensembl:ENSG00000146232	euGenes: HUgn4794
ECgene: NFKBIE	H-InvDB: NFKBIE

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NFKBIE	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NFKBIE
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NFKBIE:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NFKBIE-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NFKBIE		Antibodies for NFKBIE
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NFKBIE		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NFKBIE)
	Antibodies (NFKBIE)
	Chimera RNAi (NFKBIE)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for NFKBIE (IkBe)

	Recombinant Proteins (IKB epsilon)
	Antibodies (IKB epsilon)

Search OriGene for NFKBIE

Tocris compounds for NFKBIE

	Drugs for NFKBIE
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NFKBIE

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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NFKBIE Gene at Home site.
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NFKBIE Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for NFKBIE

Summaries
for NFKBIE

Genomic Location
for NFKBIE

Proteins
for NFKBIE

Protein Domains/
Families
for NFKBIE

Gene Function
for NFKBIE

Pathways & Interactions
for NFKBIE

Drugs & Compounds
for NFKBIE

Transcripts
for NFKBIE

Expression
for NFKBIE

Orthologs
for NFKBIE

Paralogs
for NFKBIE

SNPs/Variants
for NFKBIE

Disorders & Mutations
for NFKBIE

Medical News
for NFKBIE

Publications
for NFKBIE

Search for NFKBIE

Genome Databases showing NFKBIE

Other Databases showing NFKBIE

Specialized Databases showing NFKBIE

Licensable Technologies
for NFKBIE

Services
for NFKBIE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NFKBIE Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor NFKBIE

Summariesfor NFKBIE

Genomic Locationfor NFKBIE

Proteinsfor NFKBIE

Protein Domains/Familiesfor NFKBIE

Gene Functionfor NFKBIE

Pathways & Interactionsfor NFKBIE

Drugs & Compoundsfor NFKBIE

Transcriptsfor NFKBIE

Expression for NFKBIE

Orthologsfor NFKBIE

Paralogsfor NFKBIE

SNPs/Variantsfor NFKBIE

Disorders & Mutationsfor NFKBIE

Medical Newsfor NFKBIE

Publicationsfor NFKBIE

Search for NFKBIE

Genome Databases showing NFKBIE

Other Databases showing NFKBIE

Specialized Databases showing NFKBIE

Licensable Technologiesfor NFKBIE

Servicesfor NFKBIE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NFKBIE

Summaries
for NFKBIE

Genomic Location
for NFKBIE

Proteins
for NFKBIE

Protein Domains/
Families
for NFKBIE

Gene Function
for NFKBIE

Pathways & Interactions
for NFKBIE

Drugs & Compounds
for NFKBIE

Transcripts
for NFKBIE

Expression
for NFKBIE

Orthologs
for NFKBIE

Paralogs
for NFKBIE

SNPs/Variants
for NFKBIE

Disorders & Mutations
for NFKBIE

Medical News
for NFKBIE

Publications
for NFKBIE

Licensable Technologies
for NFKBIE

Services
for NFKBIE