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Aliases for NFKBIE Gene

Aliases for NFKBIE Gene

  • NFKB Inhibitor Epsilon 2 3 5
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon 2 3
  • NF-Kappa-B Inhibitor Epsilon 2 3
  • I-Kappa-B-Epsilon 3 4
  • IkappaBepsilon 3 4
  • NF-Kappa-BIE 3 4
  • IkB-Epsilon 3 4
  • IkB-E 3 4
  • IKBE 3 4

External Ids for NFKBIE Gene

Previous GeneCards Identifiers for NFKBIE Gene

  • GC06M044224
  • GC06M044273
  • GC06M044334
  • GC06M043947

Summaries for NFKBIE Gene

Entrez Gene Summary for NFKBIE Gene

  • The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

GeneCards Summary for NFKBIE Gene

NFKBIE (NFKB Inhibitor Epsilon) is a Protein Coding gene. Diseases associated with NFKBIE include Ebola Hemorrhagic Fever and Pleural Empyema. Among its related pathways are Toll Comparative Pathway and Activation of cAMP-Dependent PKA. An important paralog of this gene is MIR8085.

UniProtKB/Swiss-Prot for NFKBIE Gene

  • Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Wiki entry for NFKBIE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIE Gene

Genomics for NFKBIE Gene

Regulatory Elements for NFKBIE Gene

Enhancers for NFKBIE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F044056 1.9 FANTOM5 Ensembl ENCODE 30.6 +203.0 203022 13.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A YY1 SLC30A9 CBX5 POLH NFKBIE AARS2 RPS2P29 MRPL14 TMEM63B CUL9 ENSG00000271754 VEGFA SLC35B2
GH06F044255 1.6 FANTOM5 ENCODE 34.6 +4.8 4845 11.9 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 TBX21 NFKBIE AARS2 POLH ENSG00000271970 RPL29P16 ENSG00000223469 RPS2P28 TMEM151B RPS2P29 LOC101929726
GH06F044232 1.8 FANTOM5 Ensembl ENCODE 14.9 +29.9 29911 6.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLH CAPN11 RPS2P29 NFKBIE SLC35B2 MIR4647 MRPL14 TMEM63B TMEM151B LOC101929726
GH06F044033 1.6 FANTOM5 Ensembl ENCODE 13.8 +230.2 230186 3.6 HDGF SIN3A ZNF48 SLC30A9 GLIS2 ZNF143 ZNF207 SP3 SP5 MXD4 ENSG00000271970 NFKBIE C6orf223 VEGFA RSPH9 SLC29A1 GTPBP2 MAD2L1BP GC06P044013 GC06M044069
GH06F044022 1.5 FANTOM5 Ensembl ENCODE 13 +243.3 243288 1.0 MLX ZNF48 SLC30A9 FOS MXD4 ZHX2 MIER2 PPARG KAT8 MIER3 NFKBIE MAD2L1BP GC06P044013 GC06M044069
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFKBIE on UCSC Golden Path with GeneCards custom track

Promoters for NFKBIE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NFKBIE Gene

44,258,166 bp from pter
44,265,788 bp from pter
7,623 bases
Minus strand

Genomic View for NFKBIE Gene

Genes around NFKBIE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBIE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBIE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIE Gene

Proteins for NFKBIE Gene

  • Protein details for NFKBIE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NF-kappa-B inhibitor epsilon
    Protein Accession:
    Secondary Accessions:
    • Q5T9V9

    Protein attributes for NFKBIE Gene

    500 amino acids
    Molecular mass:
    52864 Da
    Quaternary structure:
    • Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.
    • Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351; Evidence={ECO:0000305};

neXtProt entry for NFKBIE Gene

Post-translational modifications for NFKBIE Gene

  • Serine phosphorylated; followed by proteasome-dependent degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFKBIE Gene

No data available for DME Specific Peptides for NFKBIE Gene

Domains & Families for NFKBIE Gene

Gene Families for NFKBIE Gene

Protein Domains for NFKBIE Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NF-kappa-B inhibitor family.
  • Contains 6 ANK repeats.
  • Belongs to the NF-kappa-B inhibitor family.
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with NFKBIE: view

Function for NFKBIE Gene

Molecular function for NFKBIE Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Ontology (GO) - Molecular Function for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with NFKBIE: view
genes like me logo Genes that share phenotypes with NFKBIE: view

Animal Models for NFKBIE Gene

MGI Knock Outs for NFKBIE:

Animal Model Products

miRNA for NFKBIE Gene

miRTarBase miRNAs that target NFKBIE

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBIE Gene

Localization for NFKBIE Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIE Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBIE gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9135156
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NFKBIE: view

Pathways & Interactions for NFKBIE Gene

genes like me logo Genes that share pathways with NFKBIE: view

SIGNOR curated interactions for NFKBIE Gene


Gene Ontology (GO) - Biological Process for NFKBIE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042942 D-serine transport IEA --
GO:0042994 cytoplasmic sequestering of transcription factor TAS 9135156
genes like me logo Genes that share ontologies with NFKBIE: view

Transcripts for NFKBIE Gene


Unigene Clusters for NFKBIE Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIE Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP3: -

Relevant External Links for NFKBIE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFKBIE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFKBIE Gene

Protein differential expression in normal tissues from HIPED for NFKBIE Gene

This gene is overexpressed in Breast (34.2), Peripheral blood mononuclear cells (11.8), Blymphocyte (8.7), and Monocytes (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFKBIE Gene

Protein tissue co-expression partners for NFKBIE Gene

NURSA nuclear receptor signaling pathways regulating expression of NFKBIE Gene:


SOURCE GeneReport for Unigene cluster for NFKBIE Gene:


mRNA Expression by UniProt/SwissProt for NFKBIE Gene:

Tissue specificity: Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
genes like me logo Genes that share expression patterns with NFKBIE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NFKBIE Gene

Orthologs for NFKBIE Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NFKBIE 34 35
  • 99.33 (n)
(Bos Taurus)
Mammalia NFKBIE 34 35
  • 86.43 (n)
(Canis familiaris)
Mammalia NFKBIE 34 35
  • 84.72 (n)
(Mus musculus)
Mammalia Nfkbie 34 16 35
  • 82.41 (n)
(Rattus norvegicus)
Mammalia Nfkbie 34
  • 82.27 (n)
(Monodelphis domestica)
Mammalia NFKBIE 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NFKBIE 35
  • 72 (a)
(Gallus gallus)
Aves NFKBIE 34 35
  • 66.37 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 17 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145466 34
  • 60.08 (n)
Str.672 34
(Danio rerio)
Actinopterygii nfkbie 34 35
  • 53.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta cact 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
Species where no ortholog for NFKBIE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFKBIE Gene

Gene Tree for NFKBIE (if available)
Gene Tree for NFKBIE (if available)

Paralogs for NFKBIE Gene

Paralogs for NFKBIE Gene

(4) SIMAP similar genes for NFKBIE Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFKBIE: view

Variants for NFKBIE Gene

Sequence variations from dbSNP and Humsavar for NFKBIE Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10081001 -- 44,259,593(+) GGGGG(A/G)CTGCT intron-variant, upstream-variant-2KB
rs1051839 -- 44,265,067(-) ACCCG(C/G)CCCCA reference, missense
rs111847883 -- 44,262,041(+) TGGGA(C/T)CCCAA intron-variant
rs112218404 -- 44,265,719(+) GCTTG(A/G)AGTCT reference, synonymous-codon
rs113726808 -- 44,265,371(+) CGGGG(C/T)CCGGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NFKBIE Gene

Variant ID Type Subtype PubMed ID
nsv603003 CNV gain 21841781
nsv5282 CNV insertion 18451855
nsv524398 CNV loss 19592680
nsv462936 CNV loss 19166990
dgv10641n54 CNV loss 21841781

Variation tolerance for NFKBIE Gene

Gene Damage Index Score: 5.20; 69.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFKBIE Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIE Gene

Disorders for NFKBIE Gene

MalaCards: The human disease database

(2) MalaCards diseases for NFKBIE Gene - From: DISEASES

Disorder Aliases PubMed IDs
ebola hemorrhagic fever
  • ebola virus disease
pleural empyema
  • abscess of pleural cavity
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NFKBIE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NFKBIE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFKBIE Gene

Publications for NFKBIE Gene

  1. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 22 46 64
  2. IkappaB genetic polymorphisms and invasive pneumococcal disease. (PMID: 17463416) Chapman S.J. … Hill A.V. (Am. J. Respir. Crit. Care Med. 2007) 3 22 46 64
  3. IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity. (PMID: 9135156) Whiteside S.T. … Israel A. (EMBO J. 1997) 2 3 4 64
  4. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y. … Yamamoto K. (Nat. Genet. 2012) 3 46 64
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64

Products for NFKBIE Gene

Sources for NFKBIE Gene

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