Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFKBIE Gene

protein-coding   GIFtS: 64
GCID: GC06M044226

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
Inhibitor, Epsilon1 2
     ikappaBepsilon2
I-kappa-B-epsilon2 3     NF-Kappa-B Inhibitor Epsilon2
IKBE2 3     IkB-E3
NF-kappa-BIE2 3     IkB-epsilon3
ikB-E2     IkappaBepsilon3
ikB-epsilon2     

External Ids:    HGNC: 77991   Entrez Gene: 47942   Ensembl: ENSG000001462327   OMIM: 6045485   UniProtKB: O002213   

Export aliases for NFKBIE gene to outside databases

Previous GC identifers: GC06M044224 GC06M044273 GC06M044334 GC06M043947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFKBIE Gene:
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and
preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for
destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the
nucleus. (provided by RefSeq, Sep 2011)

GeneCards Summary for NFKBIE Gene: 
NFKBIE (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon) is a protein-coding gene. Diseases associated with NFKBIE include gingivitis, and multiple myeloma, and among its related super-pathways are Signal transduction AKT signaling and DR3 Signaling. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of
NF-kappa-B p50-p65 and p50-c-Rel complexes

Gene Wiki entry for NFKBIE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFKBIE gene promoter:
         ISGF-3   Elk-1   GATA-3   MyoD   E47   Egr-4   Egr-2   RORalpha1   IRF-2   c-Myb   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NFKBIE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

NFKBIE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIE gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M044226:  view genomic region     (about GC identifiers)

Start:
44,225,903 bp from pter      End:
44,233,525 bp from pter
Size:
7,623 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor epsilon  
Size: 500 amino acids; 52864 Da
Subunit: Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B
p52 subunit
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351;
Secondary accessions: Q5T9V9

Explore the universe of human proteins at neXtProt for NFKBIE: NX_O00221

Explore proteomics data for NFKBIE at MOPED 

Post-translational modifications:

  • UniProtKB: Serine phosphorylated; followed by proteasome-dependent degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00221

  • NFKBIE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NFKBIE Protein Expression
    REFSEQ proteins: NP_004547.2  
    ENSEMBL proteins: 
     ENSP00000275015   ENSP00000394658   ENSP00000454778  
    Reactome Protein details: O00221
    Human Recombinant Protein Products for NFKBIE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NFKBIE
    GenScript Custom Purified and Recombinant Proteins Services for NFKBIE
    Novus Biologicals NFKBIE Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9135156
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm IEA--

    NFKBIE for ontologies           About GeneDecksing



    NFKBIE Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NFKBIE (IkB-epsilon)
    Cell Signaling Technology (CST) Antibodies for NFKBIE  (IkB-epsilon)
    OriGene Antibodies for NFKBIE
    OriGene Custom Antibody Services for NFKBIE
    GenScript Custom Superior Antibodies Services for NFKBIE
    Novus Biologicals NFKBIE Antibodies
    Abcam antibodies for NFKBIE
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for NFKBIE
    LSBio Antibodies in human, mouse, rat for NFKBIE 

    Assay Products for NFKBIE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFKBIE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFKBIE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry O00221

    ProtoNet protein and cluster: O00221

    UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221
    Similarity: Belongs to the NF-kappa-B inhibitor family
    Similarity: Contains 6 ANK repeats


    NFKBIE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKBE_HUMAN, O00221
    Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of
    NF-kappa-B p50-p65 and p50-c-Rel complexes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    NFKBIE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NFKBIE:
     Decreased nuclei size in G2M 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nfkbie):
     cellular  hematopoietic system  immune system  mortality/aging  skeleton 

    NFKBIE for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NFKBIE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFKBIE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFKBIE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFKBIE 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFKBIE
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate NFKBIE:
    hsa-miR-2355-5p hsa-miR-1184 hsa-miR-3611 hsa-miR-2115 hsa-miR-1264 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NFKBIE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFKBIE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFKBIE
    Sirion Biotech Customized adenovirus for overexpression of NFKBIE

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NFKBIE (see all 5)
    OriGene ORF clones in mouse, rat for NFKBIE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFKBIE (NM_004556)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKBIE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIE
    Sirion Biotech Customized lentivirus for stable overexpression of NFKBIE 
                         Customized lentivirus expression plasmids for stable overexpression of NFKBIE 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFKBIE
    Search LifeMap BioReagents cell lines for NFKBIE
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NFKBIE About   (see all 62)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2TWEAK Pathway
    TWEAK Pathway0.87
    Apoptosis and survival TNFR1 signaling pathway0.52
    DR3 Signaling0.87
    GITR Pathway0.46
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    TRAIL Pathway0.40
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    Immune response IL-1 signaling pathway0.41
    TLR-TRIF Pathway0.61
    IL-1 Pathway0.39
    Immune response MIF in innate immunity response0.46
    iNOS Signaling0.34
    4BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    5Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    IL-17 Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/37 EMD Millipore Pathways for NFKBIE (see all 37)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Transcription NF-kB signaling pathway

    5 R&D Systems Pathways for NFKBIE
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFKBIE (see all 56)
        TWEAK Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling

    1 Cell Signaling Technology (CST) Pathway for NFKBIE
        NF-kappaB Signaling

    5/45 GeneGo (Thomson Reuters) Pathways for NFKBIE (see all 45)
        Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    2 BioSystems Pathways for NFKBIE
        Apoptosis
    TNF-alpha/NF-kB Signaling Pathway

    5        Reactome Pathways for NFKBIE
        Downstream Signaling Events Of B Cell Receptor (BCR)
    Adaptive Immune System
    Activation of NF-kappaB in B Cells
    Immune System
    Signaling by the B Cell Receptor (BCR)


    5         Kegg Pathways  (Kegg details for NFKBIE):
        T cell receptor signaling pathway
    B cell receptor signaling pathway
    Neurotrophin signaling pathway
    Adipocytokine signaling pathway
    Epstein-Barr virus infection


    NFKBIE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFKBIE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for NFKBIE (O002212, 3 ENSP000002750154) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, 3, ENSP000002265744MINT-47886 MINT-48536 MINT-47905 MINT-48647 I2D: score=6 STRING: ENSP00000226574
    NFKB2Q006532, 3, ENSP000001894444MINT-47947 MINT-48708 I2D: score=7 STRING: ENSP00000189444
    JUPP149232, 3, ENSP000003111134MINT-67718 I2D: score=4 STRING: ENSP00000311113
    PPP6R2O751702, 3, ENSP000003790934MINT-8214278 I2D: score=3 STRING: ENSP00000379093
    CHUKO151112, 3, ENSP000003594244MINT-47878 I2D: score=2 STRING: ENSP00000359424
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042942D-serine transport IEA--
    GO:0042994cytoplasmic sequestering of transcription factor TAS9135156

    NFKBIE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFKBIE (IKBE)

    Search CenterWatch for drugs/clinical trials and news about NFKBIE / IKBE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFKBIE gene: 
    NM_004556.2  

    Unigene Cluster for NFKBIE:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
    Hs.458276  [show with all ESTs]
    Unigene Representative Sequence: NM_004556
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275015(uc003oxe.1) ENST00000443607 ENST00000477930

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFKBIE
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate NFKBIE:
    hsa-miR-2355-5p hsa-miR-1184 hsa-miR-3611 hsa-miR-2115 hsa-miR-1264 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NFKBIE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFKBIE
    Clone
    Products:
         
    OriGene clones in human, mouse for NFKBIE (see all 5)
    OriGene ORF clones in mouse, rat for NFKBIE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFKBIE (NM_004556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKBIE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIE
    Sirion Biotech Customized lentivirus for stable overexpression of NFKBIE 
                         Customized lentivirus expression plasmids for stable overexpression of NFKBIE 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFKBIE
    OriGene qSTAR qPCR primer pairs in human, mouse for NFKBIE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFKBIE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFKBIE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFKBIE

    Additional mRNA sequence: 

    AK301360.1 BC011676.2 BC063609.1 U91616.1 

    7 DOTS entries:

    DT.414540  DT.97861805  DT.100775152  DT.100775155  DT.100775245  DT.100775157  DT.91738521 

    24/521 AceView cDNA sequences (see all 521):

    BQ681874 AW665794 BQ678613 AI783658 AA293480 BU860210 BG261068 BQ949440 
    AA808209 BQ231873 CN483394 BM451910 BM798084 BE311833 CF131366 CR618464 
    BU538684 BC024288 CR616372 AA953975 BU502640 Z42389 N91286 BM709117 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIE    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                                  
    SP2:                                                                  
    SP3:              -                                                   


    ECgene alternative splicing isoforms for NFKBIE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFKBIE expression in normal human tissues (normalized intensities)      NFKBIE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTAAAAT
    NFKBIE Expression
    About this image


    NFKBIE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             bone marrow cd34+   
     
     Neuron (Nervous System)
             nerve   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast

    See NFKBIE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFKBIE

    SOURCE GeneReport for Unigene cluster: Hs.458276

    UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221
    Tissue specificity: Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and
    brain. Also expressed in granulocytes and macrophages

        SABiosciences Expression via Pathway-Focused PCR Arrays including NFKBIE: 
              NFKB Signaling Pathway in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFKBIE
    OriGene qSTAR qPCR primer pairs in human, mouse for NFKBIE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFKBIE
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFKBIE
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFKBIE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NFKBIE gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfkbie1 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 82.41(n)1
    83.06(a)1
      17 (22.58 cM)5
    180371  NM_008690.31  NP_032716.21 
     455557165 
    chicken
    (Gallus gallus)
    Aves LOC4214381 NF-kappa-B inhibitor epsilon-like 65.29(n)
    58.58(a)
      421438  XM_419490.3  XP_419490.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia AF549907.12   -- 75.5(n)    AF549907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nfkbie1 nuclear factor of kappa light polypeptide gene enhancer more 53.27(n)
    46.32(a)
      790944  NM_001080089.1  NP_001073558.1 


    ENSEMBL Gene Tree for NFKBIE (if available)
    TreeFam Gene Tree for NFKBIE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFKBIE gene
    NFKBID2  NFKBIB2  NFKBIA2  BCL32  NFKBIZ2  
    4 SIMAP similar genes for NFKBIE using alignment to 5 protein entries:     IKBE_HUMAN (see all proteins):
    IkBa    NFKBIA    PPP1R12A    BCL3

    NFKBIE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/204 SNPs in NFKBIE are shown (see all 204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100810011,2
    C,F,H--44227330(+) GGGGGG/ACTGCT 1 -- int17Minor allele frequency- A:0.01NS EA WA 616
    rs1146871881,2
    F--44227345(+) ACTCGC/TAGAAC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1920773871,2
    --44227419(+) TTCACC/GTCTCA 1 -- int10--------
    rs734356551,2
    C--44227709(+) CCCTTG/TCAGCT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1996292241,2
    --44227744(+) GGGTGC/TGCAAG 1 -- int10--------
    rs2019326121,2
    --44227747(+) TGTGCA/CAGGCC 1 -- int10--------
    rs122114481,2
    C,F--44227751(+) CAAGGC/ACCTGG 1 -- int111Minor allele frequency- A:0.09NS NA EU 2183
    rs115535891,2
    C,F--44227810(-) GTGGAG/AGATGA 2 /E syn1 ese32Minor allele frequency- A:0.01NA EU 5861
    rs1159689201,2
    --44227868(+) TGCCCA/GTGAGA 2 T M mis11Minor allele frequency- G:0.01EA 184
    rs1145726071,2
    F--44227870(+) CCCATG/AAGACC 2 /L syn11Minor allele frequency- A:0.01EA 210

    HapMap Linkage Disequilibrium report for NFKBIE (44225903 - 44233525 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NFKBIE:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5282CNV Insertion18451855
    dgv6844n71CNV Loss21882294
    nsv462936CNV Loss19166990
    nsv885857CNV Loss21882294
    nsv524398CNV Loss19592680
    nsv885851CNV Loss21882294
    dgv6843n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): NFKBIE
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NFKBIE
    DNA2.0 Custom Variant and Variant Library Synthesis for NFKBIE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604548    OMIM disorders: --

    10 diseases for NFKBIE:    About MalaCards
    gingivitis    multiple myeloma    endometrial carcinoma    myeloma
    atherosclerosis    rheumatoid arthritis    arthritis    endotheliitis
    lung cancer    breast cancer


    NFKBIE for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): NFKBIE
    Human Genome Epidemiology (HuGE) Navigator: NFKBIE (24 documents)

    Export disorders for NFKBIE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFKBIE gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with NFKBIE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity. (PubMed id 9135156)1, 2, 3 Whiteside S.T.... Israel A. (1997)
    2. IkappaB genetic polymorphisms and invasive pneumococcal disease. (PubMed id 17463416)1, 4, 9 Chapman S.J....Hill A.V. (2007)
    3. Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (2008)
    4. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (2012)
    5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    6. Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)1, 4 Potter C....Wilson A.G. (2010)
    7. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    8. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    9. Polymorphisms in oxidative stress and inflammation pa thway genes, low-dose ionizing radiation, and the risk of breast cancer among U S radiologic technologists. (PubMed id 20711808)1, 4 Schonfeld S.J....Sigurdson A.J. (2010)
    10. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4794 HGNC: 7799 AceView: NFKBIEandSLC35B2 Ensembl:ENSG00000146232 euGenes: HUgn4794
    ECgene: NFKBIE Kegg: 4794 H-InvDB: NFKBIE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFKBIE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFKBIE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFKBIE gene:
    Search GeneIP for patents involving NFKBIE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NFKBIE (IkB-epsilon)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NFKBIE   OriGene RNAi products in human, mouse, rat for NFKBIE  
     OriGene qPCR primer pairs and template standards for NFKBIE   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NFKBIE  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFKBIE   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NFKBIE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFKBIE   OriGene Custom Protein Services for NFKBIE  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFKBIE
     QIAGEN SeqTarget long-range PCR primers for resequencing NFKBIE
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIE
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFKBIE
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFKBIE
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFKBIE
     GenScript Custom Purified and Recombinant Proteins Services for NFKBIE GenScript cDNA clones with any tag delivered in your preferred vector for NFKBIE
     GenScript Custom Assay Services for NFKBIE GenScript Custom Superior Antibodies Services for NFKBIE
     GenScript Custom overexpressing Cell Line Services for NFKBIE CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NFKBIE  (IkB-epsilon)

     Regulatory tfbs in NFKBIE promoter
     Search Chromatin IP Primers for NFKBIE
     RT2 qPCR Primer Assay in human, mouse, rat NFKBIE
     GNC Network for NFKBIE
     SABiosciences PCR Arrays including human, mouse, rat NFKBIE
     Search Tocris compounds for NFKBIE (IKBE)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NFKBIE antibodies
     NFKBIE proteins
     Antibodies for NFKBIE
     See all of Abcam's Antibodies, Kits and Proteins for NFKBIE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NFKBIE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIE
     SwitchGear 3'UTR luciferase reporter plasmids for NFKBIE
     Browse SwitchGear Promoter luciferase reporter plasmids for NFKBIE
     ThermoFisher Antibodies for NFKBIE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIE
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NFKBIE
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFKBIE
    Customized:
     lentivirus for stable overexpression of NFKBIE
     lentivirus expression plasmids for stable overexpression of NFKBIE
     adenovirus for overexpression of NFKBIE
     LSBio Antibodies in human, mouse, rat for NFKBIE
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFKBIE gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4