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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NFKBIE Gene

protein-coding GIFtS: 62
GCID: GC06M044226

nuclear factor of kappa light polypeptide gene enhancer...

Explore 10 diseases affiliated with
NFKBIE via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon¹ ²		IkappaBepsilon³
IKBE¹ ² ³		NF-Kappa-B Inhibitor Epsilon²
I-Kappa-B-Epsilon¹		IkB-E³
NF-Kappa-BIE¹		IkB-Epsilon¹
IkB-E³		IkappaBepsilon³
IkB-Epsilon¹

External Ids:	HGNC: 7799¹	Entrez Gene: 4794²	Ensembl: ENSG00000146232⁷	OMIM: 604548⁵	UniProtKB: O00221³

Export aliases for NFKBIE gene to outside databases

Previous GC identifers: GC06M044224 GC06M044273 GC06M044334 GC06M043947

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFKBIE:

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and

preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction

by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. (provided

by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B

p50-p65 and p50-c-Rel complexes

Gene Wiki entry for NFKBIE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NFKBIE gene promoter:
ISGF-3 Elk-1 GATA-3 MyoD E47 Egr-4 Egr-2 RORalpha1 IRF-2 c-Myb
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NFKBIE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

NFKBIE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIE gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M044226: view genomic region (about GC identifiers)

Start:	44,225,903 bp from pter	End:	44,233,525 bp from pter
Size:	7,623 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221 (See protein sequence)

Recommended Name: NF-kappa-B inhibitor epsilon

Size: 500 amino acids; 52864 Da

Subunit: Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52

subunit

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351;

Secondary accessions: Q5T9V9

Explore the universe of human proteins at neXtProt for NFKBIE: NX_O00221

Post-translational modifications:

Serine phosphorylated; followed by proteasome-dependent degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00221

NFKBIE Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004547.2

ENSEMBL proteins:

ENSP00000275015 ENSP00000394658 ENSP00000454778

Reactome Protein details: O00221
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9135156
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	TAS	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

NFKBIE for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NFKBIE for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry O00221

ProtoNet protein and cluster: O00221

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Similarity: Belongs to the NF-kappa-B inhibitor family

Similarity: Contains 6 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B

p50-p65 and p50-c-Rel complexes

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate NFKBIE:
		hsa-miR-2355-5p hsa-miR-1184 hsa-miR-3611 hsa-miR-2115 hsa-miR-1264 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: NFKBIE 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIE

1 GenomeRNAi human phenotype for NFKBIE:

Decreased nuclei size in G2M

Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nfkbie):

cellular

hematopoietic system

immune system

mortality/aging

skeleton

NFKBIE for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/63 super-pathways (see all 63) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TWEAK Pathway

8/9 pathways (see all 9)
TWEAK Pathway	1.00	Apoptosis and survival TNFR1 signaling pathway	0.40
DR3 Signaling	0.87	TRAIL Pathway	0.40
TNFR1 Pathway	0.53	TNF Signaling	0.40
GITR Pathway	0.46	Apoptosis through Death Receptors	0.32

4-1BB Pathway

4-1BB Pathway	1.00	PKR Pathway	0.36
CD40 Signaling	0.54	SUMO Pathway	0.30
CD27 Pathway	0.48	TNFR2 Pathway	0.29
CMV and MAPK Pathways	0.38

Development_A3 receptor signaling

Development_A3 receptor signaling	1.00	Development A1 receptor signaling	0.65
Development A3 receptor signaling	1.00	G-protein signaling_G-Protein alpha-q signaling cascades	0.53
Development_A1 receptor signaling	0.65	G-protein signaling G-Protein alpha-q signaling cascades	0.53

Development_PDGF signaling via STATs and NF-kB

Development_PDGF signaling via STATs and NF-kB	1.00	Immune response IL-23 signaling pathway	0.41
Development PDGF signaling via STATs and NF-kB	1.00	Development_Angiopoietin - Tie2 signaling	0.38
Immune response_IL-23 signaling pathway	0.44	Development Angiopoietin - Tie2 signaling	0.38

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways	1.00	Cytokine production by Th17 cells in CF (Mouse model)	0.37
Cytokine production by Th17 cells in CF	0.45	Immune response_MIF-mediated glucocorticoid regulation	0.28
Mucin expression in CF via TLRs, EGFR signaling pathways	0.41	Immune response MIF-mediated glucocorticoid regulation	0.28

Pathway sources
See GeneCards unified pathways
Show all pathways

5/37 EMD Millipore Pathways for NFKBIE (see all 37)

	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	Immune response IL-1 signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Transcription NF-kB signaling pathway

2 R&D Systems Pathways for NFKBIE

	Inflammasome Activation Pathways
	Toll-Like receptor Signaling Pathways

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFKBIE (see all 56)

	TWEAK Pathway
	Toll-Like Receptors Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	G12-G13 in Cellular Signaling

1 Cell Signaling Technology (CST) Pathway for NFKBIE

NF-kappaB Signaling

5/45 GeneGo (Thomson Reuters) Pathways for NFKBIE (see all 45)

	Development A2A receptor signaling
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Development EGFR signaling pathway
	Signal transduction AKT signaling

2 BioSystems Pathways for NFKBIE

	Apoptosis
	TNF-alpha/NF-kB Signaling Pathway

5/7 Reactome Pathways for NFKBIE (see all 7)

	Ubiquitination of IkB by SCF-beta-TrCP
	Degradation of Ubiquitinated IkB (B cell)
	Downstream Signaling Events Of B Cell Receptor (BCR)
	Adaptive Immune System
	Activation of NF-kappaB in B Cells

4 Kegg Pathways (Kegg details for NFKBIE):

	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Neurotrophin signaling pathway
	Adipocytokine signaling pathway

NFKBIE for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NFKBIE

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for NFKBIE (O00221^{2, 3} ENSP00000275015⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838²^,³, ENSP00000226574⁴	MINT-47886 MINT-48536 MINT-47905 MINT-48647 I2D: score=6 STRING: ENSP00000226574
NFKB2	Q00653²^,³, ENSP00000189444⁴	MINT-47947 MINT-48708 I2D: score=7 STRING: ENSP00000189444
JUP	P14923²^,³, ENSP00000311113⁴	MINT-67718 I2D: score=4 STRING: ENSP00000311113
PPP6R2	O75170²^,³, ENSP00000379093⁴	MINT-8214278 I2D: score=3 STRING: ENSP00000379093
CHUK	O15111²^,³, ENSP00000359424⁴	MINT-47878 I2D: score=2 STRING: ENSP00000359424

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042942	D-serine transport	IEA	--
GO:0042994	cytoplasmic sequestering of transcription factor	TAS	9135156

NFKBIE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NFKBIE
Search CenterWatch for drugs/clinical trials and news about NFKBIE / IKBE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NFKBIE gene:

NM_004556.2

Unigene Cluster for NFKBIE:

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Hs.458276 [show with all ESTs]

Unigene Representative Sequence: NM_004556

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000275015(uc003oxe.1) ENST00000443607 ENST00000477930

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		hsa-miR-2355-5p hsa-miR-1184 hsa-miR-3611 hsa-miR-2115 hsa-miR-1264 hsa-miR-3692
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Additional cDNA sequence:

AK301360.1 BC011676.2 BC063609.1 U91616.1

7 DOTS entries:

DT.414540 DT.97861805 DT.100775152 DT.100775155 DT.100775245 DT.100775157 DT.91738521

24/521 AceView cDNA sequences (see all 521):

BU538684 AK075456 CR616372 BM759339 BQ687391 BQ416606 BM798639 Z38599

AI653075 Z42389 AL527841 AW665794 CA443693 CR599256 BM709550 BU860210

AI783658 AI247313 BU163977 AA744668 BQ682460 CF131366 AA298497 BU183388

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIE About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b
SP1:
SP2:
SP3:					-

ECgene alternative splicing isoforms for NFKBIE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NFKBIE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTAAAAT

About this image

NFKBIE expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NFKBIE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NFKBIE

SOURCE GeneReport for Unigene cluster: Hs.458276

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Tissue specificity: Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and

brain. Also expressed in granulocytes and macrophages

SABiosciences Expression via Pathway-Focused PCR Arrays including NFKBIE:

NFKB Signaling Pathway in human mouse rat

Cancer Drug Resistance in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NFKBIE gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC421438¹	NF-kappa-B inhibitor epsilon-like	65.29(n) 58.58(a)		421438 XM_419490.3 XP_419490.3
lizard (Anolis carolinensis)	Reptilia	NFKBIE⁶	--	55(a)	1 ↔ 1	1(227963568-227968901)
African clawed frog (Xenopus laevis)	Amphibia	AF549907.1²	--	75.5(n)		AF549907.1
zebrafish (Danio rerio)	Actinopterygii	nfkbie¹	nuclear factor of kappa light polypeptide gene enhancer more	53.27(n) 46.32(a)		790944 NM_001080089.1 NP_001073558.1
fruit fly (Drosophila melanogaster)	Insecta	cact⁶	cactus	18(a)	1 → many	2L(16313029-16326101)

ENSEMBL Gene Tree for NFKBIE (if available)
TreeFam Gene Tree for NFKBIE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NFKBIE gene

NFKBID² NFKBIA² NFKBIB² BCL3² NFKBIZ²

4 SIMAP similar genes for NFKBIE using alignment to 5 protein entries: IKBE_HUMAN (see all proteins):

IkBa NFKBIA PPP1R12A BCL3

NFKBIE for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186786037^1,2		--	44225432(+)	`GCCCTA/GAAGAG`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs191589345^1,2		--	44225531(+)	`GACATC/TGAGGC`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs79042593^1,2		--	44225552(+)	`AAGCCC/GCTCCT`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs78715716^1,2		--	44225659(+)	`TCTACA/GTGGCC`	2	--	us2k¹ ds500¹		1		NA	120
rs75860078^1,2	F,	--	44225699(+)	`CCGCTG/CTGAAG`	2	--	us2k¹ ds500¹		1		WA	118
rs182622951^1,2		--	44225705(+)	`TGAAGA/CCCCAC`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs187864419^1,2		--	44225716(+)	`TGGCTC/TGCTCT`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs9394996^1,2	C,F,H,	--	44225723(+)	`CTCTCA/CGTTCC`	2	--	us2k¹ ds500¹		12		NS EA NA	1418
rs192941689^1,2		--	44225756(+)	`TAATGC/TTCTGC`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs28362194^1,2	C,F,	--	44225860(-)	`GAAAA-/AGGATG`	2	--	ds500¹ us2k¹		2		NS	92

HapMap Linkage Disequilibrium report for NFKBIE (44225903 - 44233525 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NFKBIE: --
Human Gene Mutation Database (HGMD): NFKBIE

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NFKBIE for disorders           About GeneDecksing

OMIM gene information: 604548    OMIM disorders: --

10 diseases for NFKBIE:    About MalaCards

multiple myeloma rheumatoid arthritis endometrial carcinoma myeloma

pulmonary disease gingivitis arthritis breast cancer

atherosclerosis carcinoma

Human Genome Epidemiology (HuGE) Navigator: NFKBIE (24 documents)

Export disorders for NFKBIE gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NFKBIE gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with NFKBIE)

Utopia: connect your pdf to the dynamic
world of online information

IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity. (PubMed id 9135156)^{1, 2, 3} Whiteside S.T.... Israel A. (1997)
A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. (PubMed id 9315679)^{1, 2} Li Z. and Nabel G.J. (1997)
IkappaB genetic polymorphisms and invasive pneumococcal disease. (PubMed id 17463416)^{1, 9} Chapman S.J....Hill A.V. (2007)
Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. (PubMed id 14595753)^{1, 9} Emmerich F....Dorken B. (2003)
Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)^{1, 9} Dieguez-Gonzalez R....Gonzalez A. (2008)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)¹ Okada Y....Yamamoto K. (2012)
Functional variants in NFKBIE and RTKN2 involved in ac tivation of the NF-kB pathway are associated with rheumatoid arthritis in Japane se. (PubMed id 23028356)¹ Myouzen K....Yamamoto K. (2012)
Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)¹ Ryckman K.K....Jacobsson B. (2010)
Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)¹ Potter C....Wilson A.G. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4794	HGNC: 7799	AceView: NFKBIEandSLC35B2	Ensembl:ENSG00000146232	euGenes: HUgn4794
ECgene: NFKBIE	Kegg: 4794	H-InvDB: NFKBIE

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NFKBIE	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NFKBIE	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NFKBIE gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NFKBIE gene:
Search GeneIP for patents involving NFKBIE

GeneCards and IP:
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