Aliases for NFKBIE Gene
Aliases for NFKBIE Gene
External Ids for NFKBIE Gene
- HGNC: 7799
- Entrez Gene: 4794
- Ensembl: ENSG00000146232
- OMIM: 604548
- UniProtKB: O00221
Previous GeneCards Identifiers for NFKBIE Gene
- GC06M044224
- GC06M044273
- GC06M044334
- GC06M043947
Summaries for NFKBIE Gene
-
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
GeneCards Summary for NFKBIE Gene
NFKBIE (NFKB Inhibitor Epsilon) is a Protein Coding gene. Diseases associated with NFKBIE include Pneumococcal Meningitis and Ebola Hemorrhagic Fever. Among its related pathways are PEDF Induced Signaling and NFAT and Cardiac Hypertrophy. An important paralog of this gene is BCL3.
UniProtKB/Swiss-Prot for NFKBIE Gene
-
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Additional gene information for NFKBIE Gene
- Monarch Initiative
- Search for NFKBIE at DataMed
- Search for NFKBIE at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIE Gene
Genomics for NFKBIE Gene
GeneHancer (GH) Regulatory Elements for NFKBIE Gene
Promoters and enhancers for NFKBIE Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NFKBIE on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NFKBIE Gene
Genomic Locations for NFKBIE Gene
- chr6:44,258,166-44,265,788
- (GRCh38/hg38)
- Size:
- 7,623 bases
- Orientation:
- Minus strand
- chr6:44,225,903-44,233,525
- (GRCh37/hg19)
Genomic View for NFKBIE Gene
Genes around NFKBIE on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.1 by Ensembl
- 6p21.1 by Entrez Gene
- 6p21.1 by HGNC
NFKBIE Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NFKBIE Gene
Proteins for NFKBIE Gene
-
Protein details for NFKBIE Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00221-IKBE_HUMAN
- Recommended name:
- NF-kappa-B inhibitor epsilon
- Protein Accession:
- O00221
- Q5T9V9
Protein attributes for NFKBIE Gene
- Size:
- 500 amino acids
- Molecular mass:
- 52864 Da
- Quaternary structure:
-
- Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.
- SequenceCaution:
-
- Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351; Evidence={ECO:0000305};
Protein Expression for NFKBIE Gene
Post-translational modifications for NFKBIE Gene
- Serine phosphorylated; followed by proteasome-dependent degradation.
Other Protein References for NFKBIE Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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-
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Protein Products
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-
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Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for NFKBIE (IkB-epsilon)
- antibodies-online: Search results for 9 available Nfkbie Elisa Kits ranked by validation data
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Recommended
- 1 Chicken ELISA Kit
- 1 Guinea Pig ELISA Kit
- 3 Human ELISA Kits
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- 1 Mouse (Murine) ELISA Kit
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- 1 Rabbit ELISA Kit
- 2 Rat (Rattus) ELISA Kits
- 1 Chicken ELISA Kit
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- 3 Human ELISA Kits
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- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
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No data available for DME Specific Peptides for NFKBIE Gene
Domains & Families for NFKBIE Gene
Gene Families for NFKBIE Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NFKBIE Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NFKBIE Gene
Graphical View of Domain Structure for InterPro Entry
O00221- Family:
-
- Belongs to the NF-kappa-B inhibitor family.
Function for NFKBIE Gene
Molecular function for NFKBIE Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Phenotypes From GWAS Catalog for NFKBIE Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14743216 |
Phenotypes for NFKBIE Gene
- MGI mutant phenotypes for NFKBIE:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NFKBIE:
Animal Models for NFKBIE Gene
- MGI Knock Outs for NFKBIE:
-
- Nfkbie tm1Syme
Animal Model Products
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-
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CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for NFKBIE Gene
- miRTarBase miRNAs that target NFKBIE
miRNA Products
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Inhibitory RNA Products
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-
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Cell Line Products
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBIE Gene
Localization for NFKBIE Gene
Subcellular locations from UniProtKB/Swiss-Prot for NFKBIE Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (3)
- Nucleoli fibrillar center (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | TAS | 9135156 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for NFKBIE Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
.87
.87
.56
.55
|
.46
.40
|
| 2 | 4-1BB Pathway |
.54
.54
.48
|
.37
.36
.30
|
| 3 | RANK Signaling in Osteoclasts |
.92
|
.38
|
| 4 | PEDF Induced Signaling |
.61
|
|
| 5 | Toll Comparative Pathway |
.61
|
.39
.34
|
Pathways by source for NFKBIE Gene
1 Cell Signaling Technology pathway for NFKBIE Gene
2 BioSystems pathways for NFKBIE Gene
5 Reactome pathways for NFKBIE Gene
45 GeneGo (Thomson Reuters) pathways for NFKBIE Gene
7 R&D Systems pathways for NFKBIE Gene
56 Qiagen pathways for NFKBIE Gene
Interacting Proteins for NFKBIE Gene
Selected Interacting proteins:
ENSP00000275015
O00221-IKBE_HUMAN
for NFKBIE Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042942 | D-serine transport | IEA | -- |
| GO:0042994 | cytoplasmic sequestering of transcription factor | TAS | 9135156 |
Transcripts for NFKBIE Gene
mRNA/cDNA for NFKBIE Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (521) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NFKBIE Gene
CRISPR Products
-
OriGene CRISPR knockouts for NFKBIE
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NFKBIE
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | - |
Expression for NFKBIE Gene
This gene is overexpressed in Breast (34.2), Peripheral blood mononuclear cells (11.8), Blymphocyte (8.7), and Monocytes (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFKBIE Gene
NURSA nuclear receptor signaling pathways regulating expression of NFKBIE Gene:
NFKBIESOURCE GeneReport for Unigene cluster for NFKBIE Gene:
Hs.458276mRNA Expression by UniProt/SwissProt for NFKBIE Gene:
O00221-IKBE_HUMAN
Tissue specificity:
Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
Evidence on tissue expression from TISSUES for NFKBIE Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for NFKBIE
-
OriGene qPCR primer pairs and template standards for NFKBIE
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKBIE Gene
Orthologs for NFKBIE Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NFKBIE 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NFKBIE 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NFKBIE 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Nfkbie 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nfkbie 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NFKBIE 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NFKBIE 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NFKBIE 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100145466 33 |
|
||
| Str.672 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | nfkbie 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | cact 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for NFKBIE was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NFKBIE Gene
(4) SIMAP similar genes for NFKBIE Gene using alignment to 5 proteins:
Variants for NFKBIE Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000289298 | -- | 44,260,996(-) | G/A | intron_variant | |
| rs1000856370 | -- | 44,261,563(-) | C/T | intron_variant | |
| rs1000894460 | -- | 44,259,307(-) | G/A | intron_variant | |
| rs1001042814 | -- | 44,265,743(-) | C/G | coding_sequence_variant, missense_variant | |
| rs1001189057 | -- | 44,259,908(-) | T/G | intron_variant |
Gene Damage Index Score:
5.20;
69.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NFKBIE Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIE Gene
Disorders for NFKBIE Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pneumococcal meningitis |
|
|
| ebola hemorrhagic fever |
|
|
| pleural empyema |
|
|
Search NFKBIE in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NFKBIE
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NFKBIE Gene
Publications for NFKBIE Gene
- Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R … Gonzalez A (Annals of the rheumatic diseases 2009) 3 22 44 58
- IkappaB genetic polymorphisms and invasive pneumococcal disease. (PMID: 17463416) Chapman SJ … Hill AV (American journal of respiratory and critical care medicine 2007) 3 22 44 58
- I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. (PMID: 9135156) Whiteside ST … Israël A (The EMBO journal 1997) 2 3 4 58
- Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 44 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
Products for NFKBIE Gene
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- antibodies-online: Search results for 116 available Nfkbie Antibodies ranked by validation data
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- Recommended
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- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-rat)
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- antibodies-online: Search results for 9 available Nfkbie Elisa Kits ranked by validation data
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- Recommended
- 1 Chicken ELISA Kit
- 1 Guinea Pig ELISA Kit
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- 1 Mouse (Murine) ELISA Kit
- 1 Pig (Porcine) ELISA Kit
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- 1 Chicken ELISA Kit
- 1 Guinea Pig ELISA Kit
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- 1 Monkey ELISA Kit
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- 1 Rabbit ELISA Kit
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- antibodies-online: Search results for 6 available Nfkbie Proteins ranked by validation data
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- GeneTex NFKBIE antibody for NFKBIE
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- ViGene Biosciences adenoviral particle packaged cDNA for NFKBIE gene
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- genomics-online: cdna clones - Search results for 84 available Nfkbie gene related products
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- genomics-online: shRNA clones - Search results for 84 available Nfkbie gene related products
- Overview of 84 available Nfkbie gene related products
Sources for NFKBIE Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
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