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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NFKBIE Gene

protein-coding GIFtS: 64
GCID: GC06M044226

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...

Pneumococci & Pneumococcal Diseases Congress

10 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon¹ ²		ikappaBepsilon²
I-kappa-B-epsilon² ³		NF-Kappa-B Inhibitor Epsilon²
IKBE² ³		IkB-E³
NF-kappa-BIE² ³		IkB-epsilon³
ikB-E²		IkappaBepsilon³
ikB-epsilon²

External Ids:	HGNC: 7799¹	Entrez Gene: 4794²	Ensembl: ENSG00000146232⁷	OMIM: 604548⁵	UniProtKB: O00221³

Export aliases for NFKBIE gene to outside databases

Previous GC identifers: GC06M044224 GC06M044273 GC06M044334 GC06M043947

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFKBIE Gene:

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and

preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for

destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the

nucleus. (provided by RefSeq, Sep 2011)

GeneCards Summary for NFKBIE Gene:

NFKBIE (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon) is a protein-coding gene. Diseases associated with NFKBIE include gingivitis, and multiple myeloma, and among its related super-pathways are Signal transduction AKT signaling and DR3 Signaling. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of

NF-kappa-B p50-p65 and p50-c-Rel complexes

Gene Wiki entry for NFKBIE Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.2 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NFKBIE gene promoter:
ISGF-3 Elk-1 GATA-3 MyoD E47 Egr-4 Egr-2 RORalpha1 IRF-2 c-Myb
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NFKBIE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

NFKBIE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIE gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M044226: view genomic region (about GC identifiers)

Start:	44,225,903 bp from pter	End:	44,233,525 bp from pter
Size:	7,623 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221 (See protein sequence)

Recommended Name: NF-kappa-B inhibitor epsilon

Size: 500 amino acids; 52864 Da

Subunit: Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B

p52 subunit

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAC51216.1; Type=Frameshift; Positions=339, 351;

Secondary accessions: Q5T9V9

Explore the universe of human proteins at neXtProt for NFKBIE: NX_O00221

Explore proteomics data for NFKBIE at MOPED

Post-translational modifications:

UniProtKB: Serine phosphorylated; followed by proteasome-dependent degradation

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_O00221

NFKBIE Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_004547.2

ENSEMBL proteins:

ENSP00000275015 ENSP00000394658 ENSP00000454778

Reactome Protein details: O00221
Human Recombinant Protein Products for NFKBIE:

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	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9135156
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	TAS	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

NFKBIE for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ANKRD: Ankyrin repeat domain containing

2 InterPro protein domains:

IPR002110 Ankyrin_rpt

IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry O00221

ProtoNet protein and cluster: O00221

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Similarity: Belongs to the NF-kappa-B inhibitor family

Similarity: Contains 6 ANK repeats

NFKBIE for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IKBE_HUMAN, O00221

Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of

NF-kappa-B p50-p65 and p50-c-Rel complexes

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

NFKBIE for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NFKBIE:

Decreased nuclei size in G2M

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nfkbie):

cellular

hematopoietic system

immune system

mortality/aging

skeleton

NFKBIE for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for NFKBIE

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFKBIE

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFKBIE

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		hsa-miR-2355-5p hsa-miR-1184 hsa-miR-3611 hsa-miR-2115 hsa-miR-1264 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: NFKBIE 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIE

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for NFKBIE About (see all 62)

See pathways by source

SuperPath

Contained pathways About

Development IGF-RI signaling

	Development IGF-RI signaling	0.49			Development IGF-1 receptor signaling	0.48
	Signal transduction AKT signaling	0.49

TWEAK Pathway

TWEAK Pathway	0.87	Apoptosis and survival TNFR1 signaling pathway	0.52
DR3 Signaling	0.87	GITR Pathway	0.46
TNFR1 Pathway	0.56	Apoptosis through Death Receptors	0.42
TNF Signaling	0.55	TRAIL Pathway	0.40

Toll Comparative Pathway

Toll Comparative Pathway	0.61	Immune response IL-1 signaling pathway	0.41
TLR-TRIF Pathway	0.61	IL-1 Pathway	0.39
Immune response MIF in innate immunity response	0.46	iNOS Signaling	0.34

BAFF in B-Cell Signaling

BAFF in B-Cell Signaling	0.92	Apoptosis and survival APRIL and BAFF signaling	0.39
APRIL Pathway	0.92	RANK Pathway	0.38
RANK Signaling in Osteoclasts	0.45

Mucin expression in CF via IL-6, IL-17 signaling pathways

	Mucin expression in CF via IL-6, IL-17 signaling pathways	0.48			Mucin expression in CF via TLRs, EGFR signaling pathways	0.41
	IL-17 Signaling	0.48

Pathways by source See SuperPaths
Show all pathways

5/37 EMD Millipore Pathways for NFKBIE (see all 37)

	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	Immune response IL-1 signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Transcription NF-kB signaling pathway

5 R&D Systems Pathways for NFKBIE

	NOD-like Receptor Signaling Pathways
	Inflammasome Activation Pathways
	IL-17 Signaling
	Toll-Like receptor Signaling Pathways
	Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFKBIE (see all 56)

	TWEAK Pathway
	Toll-Like Receptors Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	G12-G13 in Cellular Signaling

1 Cell Signaling Technology (CST) Pathway for NFKBIE

NF-kappaB Signaling

5/45 GeneGo (Thomson Reuters) Pathways for NFKBIE (see all 45)

	Development A2A receptor signaling
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Development EGFR signaling pathway
	Signal transduction AKT signaling

2 BioSystems Pathways for NFKBIE

	Apoptosis
	TNF-alpha/NF-kB Signaling Pathway

5 Reactome Pathways for NFKBIE

	Downstream Signaling Events Of B Cell Receptor (BCR)
	Adaptive Immune System
	Activation of NF-kappaB in B Cells
	Immune System
	Signaling by the B Cell Receptor (BCR)

5 Kegg Pathways (Kegg details for NFKBIE):

	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Neurotrophin signaling pathway
	Adipocytokine signaling pathway
	Epstein-Barr virus infection

NFKBIE for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NFKBIE

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/76 Interacting proteins for NFKBIE (O00221^{2, 3} ENSP00000275015⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838²^,³, ENSP00000226574⁴	MINT-47886 MINT-48536 MINT-47905 MINT-48647 I2D: score=6 STRING: ENSP00000226574
NFKB2	Q00653²^,³, ENSP00000189444⁴	MINT-47947 MINT-48708 I2D: score=7 STRING: ENSP00000189444
JUP	P14923²^,³, ENSP00000311113⁴	MINT-67718 I2D: score=4 STRING: ENSP00000311113
PPP6R2	O75170²^,³, ENSP00000379093⁴	MINT-8214278 I2D: score=3 STRING: ENSP00000379093
CHUK	O15111²^,³, ENSP00000359424⁴	MINT-47878 I2D: score=2 STRING: ENSP00000359424

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042942	D-serine transport	IEA	--
GO:0042994	cytoplasmic sequestering of transcription factor	TAS	9135156

NFKBIE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NFKBIE (IKBE)

Search CenterWatch for drugs/clinical trials and news about NFKBIE / IKBE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NFKBIE gene:

NM_004556.2

Unigene Cluster for NFKBIE:

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Hs.458276 [show with all ESTs]

Unigene Representative Sequence: NM_004556

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000275015(uc003oxe.1) ENST00000443607 ENST00000477930

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate NFKBIE:
		hsa-miR-2355-5p hsa-miR-1184 hsa-miR-3611 hsa-miR-2115 hsa-miR-1264 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: NFKBIE 3' UTR sequence

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Additional mRNA sequence:

AK301360.1 BC011676.2 BC063609.1 U91616.1

7 DOTS entries:

DT.414540 DT.97861805 DT.100775152 DT.100775155 DT.100775245 DT.100775157 DT.91738521

24/521 AceView cDNA sequences (see all 521):

BQ681874 AW665794 BQ678613 AI783658 AA293480 BU860210 BG261068 BQ949440

AA808209 BQ231873 CN483394 BM451910 BM798084 BE311833 CF131366 CR618464

BU538684 BC024288 CR616372 AA953975 BU502640 Z42389 N91286 BM709117

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIE About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b
SP1:
SP2:
SP3:					-

ECgene alternative splicing isoforms for NFKBIE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NFKBIE expression in normal human tissues (normalized intensities) NFKBIE embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACACTAAAAT

About this image

NFKBIE expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/5 selected tissues (see all 5) fully expand


Blood (Hematopoietic System) fully expand to see all 2 entries
bone marrow cd34+

Neuron (Nervous System)
nerve

Umbilical Cord (Extraembryonic Tissues)
stem cells (umbilical cord cd34+)

Inner Cell Mass (Early Embryonic Tissues)
Blimp1- mVenus and stella-ECFP genetically modified stem cells

Epiblast (Early Embryonic Tissues)
Epiblast Cells Epiblast

See NFKBIE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NFKBIE

SOURCE GeneReport for Unigene cluster: Hs.458276

UniProtKB/Swiss-Prot: IKBE_HUMAN, O00221

Tissue specificity: Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and

brain. Also expressed in granulocytes and macrophages

SABiosciences Expression via Pathway-Focused PCR Arrays including NFKBIE:

NFKB Signaling Pathway in human mouse rat

Cancer Drug Resistance in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NFKBIE gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Nfkbie^{1 , 5}	nuclear factor of kappa light polypeptide gene enhancer more^{1, 5}	82.41(n)¹ 83.06(a)¹	17 (22.58 cM)⁵ 18037¹ NM_008690.3¹ NP_032716.2¹ 45555716⁵
chicken (Gallus gallus)	Aves	LOC421438¹	NF-kappa-B inhibitor epsilon-like	65.29(n) 58.58(a)	421438 XM_419490.3 XP_419490.3
African clawed frog (Xenopus laevis)	Amphibia	AF549907.1²	--	75.5(n)	AF549907.1
zebrafish (Danio rerio)	Actinopterygii	nfkbie¹	nuclear factor of kappa light polypeptide gene enhancer more	53.27(n) 46.32(a)	790944 NM_001080089.1 NP_001073558.1

ENSEMBL Gene Tree for NFKBIE (if available)
TreeFam Gene Tree for NFKBIE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NFKBIE gene

NFKBID² NFKBIB² NFKBIA² BCL3² NFKBIZ²

4 SIMAP similar genes for NFKBIE using alignment to 5 protein entries: IKBE_HUMAN (see all proteins):

IkBa NFKBIA PPP1R12A BCL3

NFKBIE for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10081001^1,2	C,F,H	--	44227330(+)	`GGGGGG/ACTGCT`	1	--	int¹		7		NS EA WA	616
rs114687188^1,2	F	--	44227345(+)	`ACTCGC/TAGAAC`	1	--	int¹		1		WA	118
rs192077387^1,2		--	44227419(+)	`TTCACC/GTCTCA`	1	--	int¹		0	--	--	--	--
rs73435655^1,2	C	--	44227709(+)	`CCCTTG/TCAGCT`	1	--	int¹		1		WA	2
rs199629224^1,2		--	44227744(+)	`GGGTGC/TGCAAG`	1	--	int¹		0	--	--	--	--
rs201932612^1,2		--	44227747(+)	`TGTGCA/CAGGCC`	1	--	int¹		0	--	--	--	--
rs12211448^1,2	C,F	--	44227751(+)	`CAAGGC/ACCTGG`	1	--	int¹		11		NS NA EU	2183
rs11553589^1,2	C,F	--	44227810(-)	`GTGGAG/AGATGA`	2	/E	syn¹ ese³		2		NA EU	5861
rs115968920^1,2		--	44227868(+)	`TGCCCA/GTGAGA`	2	T M	mis¹		1		EA	184
rs114572607^1,2	F	--	44227870(+)	`CCCATG/AAGACC`	2	/L	syn¹		1		EA	210

HapMap Linkage Disequilibrium report for NFKBIE (44225903 - 44233525 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for NFKBIE: About this table

Variant ID	Type	Subtype	PubMed ID
nsv5282	CNV	Insertion	18451855
dgv6844n71	CNV	Loss	21882294
nsv462936	CNV	Loss	19166990
nsv885857	CNV	Loss	21882294
nsv524398	CNV	Loss	19592680
nsv885851	CNV	Loss	21882294
dgv6843n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): NFKBIE

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 604548 OMIM disorders: --

10 diseases for NFKBIE: About MalaCards

gingivitis multiple myeloma endometrial carcinoma myeloma

atherosclerosis rheumatoid arthritis arthritis endotheliitis

lung cancer breast cancer

NFKBIE for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Genetic Association Database (GAD): NFKBIE
Human Genome Epidemiology (HuGE) Navigator: NFKBIE (24 documents)

Export disorders for NFKBIE gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NFKBIE gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with NFKBIE)

Utopia: connect your pdf to the dynamic
world of online information

IkappaB epsilon, a novel member of the IkappaB family, controls RelA and cRel NF-kappaB activity. (PubMed id 9135156)^{1, 2, 3} Whiteside S.T.... Israel A. (1997)
IkappaB genetic polymorphisms and invasive pneumococcal disease. (PubMed id 17463416)^{1, 4, 9} Chapman S.J....Hill A.V. (2007)
Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)^{1, 4, 9} Dieguez-Gonzalez R....Gonzalez A. (2008)
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)^{1, 4} Okada Y....Yamamoto K. (2012)
Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)^{1, 4} Ryckman K.K....Jacobsson B. (2010)
Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)^{1, 4} Potter C....Wilson A.G. (2010)
Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)^{1, 4} Guey L.T....Malats N. (2010)
Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)^{1, 4} Segat L....Crovella S. (2010)
Polymorphisms in oxidative stress and inflammation pa thway genes, low-dose ionizing radiation, and the risk of breast cancer among U S radiologic technologists. (PubMed id 20711808)^{1, 4} Schonfeld S.J....Sigurdson A.J. (2010)
Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4794	HGNC: 7799	AceView: NFKBIEandSLC35B2	Ensembl:ENSG00000146232	euGenes: HUgn4794
ECgene: NFKBIE	Kegg: 4794	H-InvDB: NFKBIE

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NFKBIE	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NFKBIE	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NFKBIE gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NFKBIE gene:
Search GeneIP for patents involving NFKBIE

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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