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Aliases for NFKBID Gene

Aliases for NFKBID Gene

  • NFKB Inhibitor Delta 2 3 5
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Delta 2 3
  • T-Cell Activation NFKB-Like Protein 3 4
  • NF-Kappa-B Inhibitor Delta 2 3
  • I-Kappa-B-Delta 3 4
  • IkappaBdelta 3 4
  • IkB-Delta 3 4
  • IkappaBNS 3 4
  • TA-NFKBH 3 4
  • IKBNS 4

External Ids for NFKBID Gene

Previous GeneCards Identifiers for NFKBID Gene

  • GC19M041072
  • GC19M036379
  • GC19M032884
  • GC19M036382
  • GC19M036544
  • GC19M037063

Summaries for NFKBID Gene

GeneCards Summary for NFKBID Gene

NFKBID (NFKB Inhibitor Delta) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding. An important paralog of this gene is NFKBIZ.

UniProtKB/Swiss-Prot for NFKBID Gene

  • May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBID Gene

Genomics for NFKBID Gene

Regulatory Elements for NFKBID Gene

Enhancers for NFKBID Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035897 1.3 FANTOM5 ENCODE 20.6 -1.7 -1724 13.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 TMEM147-AS1 ZNF345 ZNF850 KMT2B ZNF792 RBM42 ENSG00000267049 ZNF790-AS1 ZNF529-AS1 ZNF790
GH19F035429 1.3 FANTOM5 Ensembl ENCODE 15.3 +471.5 471497 2.4 PKNOX1 ZNF493 ZFP64 ZNF155 ZEB1 ZNF354C ZNF138 KLF7 ZNF548 ZNF202 TMEM147-AS1 HAUS5 KMT2B ZNF792 RBM42 ZNF146 ZFP82 ENSG00000267049 SDHAF1 LINC00665
GH19F035433 1.3 FANTOM5 Ensembl ENCODE 14.3 +466.2 466234 5.8 ELF3 HDAC1 PKNOX1 THRB RAD21 RARA YY1 ZNF121 SCRT2 ETV6 NFKBID TMEM147-AS1 FFAR2 KRTDAP DMKN CD22 MIR5196 SBSN FAM187B TYROBP
GH19F035913 1.4 FANTOM5 ENCODE 11 -11.7 -11655 1.0 HDGF PKNOX1 ZNF362 MTA2 JUNB TRIM22 EBF1 TBX21 ZNF121 ZNF302 TYROBP APLP1 NPHS1 KIRREL2 NFKBID SDHAF1 HCST FFAR2 IGFLR1 U2AF1L4
GH19F035457 1.1 FANTOM5 Ensembl ENCODE 10.7 +441.2 441234 6.6 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B YBX1 YY1 SLC30A9 ZNF263 SP3 TMEM147-AS1 HAUS5 KMT2B RBM42 ZNF146 ZNF792 ENSG00000267049 SDHAF1 ZFP82 LRFN3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NFKBID on UCSC Golden Path with GeneCards custom track

Promoters for NFKBID Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001817302 -766 1801 HDGF PKNOX1 ATF1 CREB3L1 SIN3A ARID4B ZNF2 ZNF121 GLIS2 ELK1

Genomic Location for NFKBID Gene

Chromosome:
19
Start:
35,887,129 bp from pter
End:
35,902,334 bp from pter
Size:
15,206 bases
Orientation:
Minus strand

Genomic View for NFKBID Gene

Genes around NFKBID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBID Gene

Proteins for NFKBID Gene

  • Protein details for NFKBID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI38-IKBD_HUMAN
    Recommended name:
    NF-kappa-B inhibitor delta
    Protein Accession:
    Q8NI38
    Secondary Accessions:
    • Q8NI39
    • Q9BRG9

    Protein attributes for NFKBID Gene

    Size:
    313 amino acids
    Molecular mass:
    33481 Da
    Quaternary structure:
    • Interacts with NFKB1, RELA and RELB; in the nucleus.

    Alternative splice isoforms for NFKBID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBID Gene

Post-translational modifications for NFKBID Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFKBID Gene

Domains & Families for NFKBID Gene

Gene Families for NFKBID Gene

Protein Domains for NFKBID Gene

Suggested Antigen Peptide Sequences for NFKBID Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI38

UniProtKB/Swiss-Prot:

IKBD_HUMAN :
  • Belongs to the NF-kappa-B inhibitor family.
  • Contains 6 ANK repeats.
Family:
  • Belongs to the NF-kappa-B inhibitor family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with NFKBID: view

Function for NFKBID Gene

Molecular function for NFKBID Gene

UniProtKB/Swiss-Prot Function:
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).

Gene Ontology (GO) - Molecular Function for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0051059 NF-kappaB binding IEA --
genes like me logo Genes that share ontologies with NFKBID: view
genes like me logo Genes that share phenotypes with NFKBID: view

Animal Models for NFKBID Gene

MGI Knock Outs for NFKBID:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBID Gene

Localization for NFKBID Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBID Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFKBID Gene COMPARTMENTS Subcellular localization image for NFKBID gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with NFKBID: view

Pathways & Interactions for NFKBID Gene

SuperPathways for NFKBID Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006954 inflammatory response IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA --
GO:0033085 negative regulation of T cell differentiation in thymus IEA --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with NFKBID: view

No data available for Pathways by source and SIGNOR curated interactions for NFKBID Gene

Transcripts for NFKBID Gene

Unigene Clusters for NFKBID Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBID Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8:
SP9: -
SP10: -

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NFKBID Gene

GeneLoc Exon Structure for
NFKBID
ECgene alternative splicing isoforms for
NFKBID

Expression for NFKBID Gene

mRNA expression in normal human tissues for NFKBID Gene

mRNA differential expression in normal tissues according to GTEx for NFKBID Gene

This gene is overexpressed in Whole Blood (x10.9).

NURSA nuclear receptor signaling pathways regulating expression of NFKBID Gene:

NFKBID

SOURCE GeneReport for Unigene cluster for NFKBID Gene:

Hs.466531
genes like me logo Genes that share expression patterns with NFKBID: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NFKBID Gene

Orthologs for NFKBID Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBID 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia NFKBID 34 35
  • 87.93 (n)
cow
(Bos Taurus)
Mammalia NFKBID 34 35
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia Nfkbid 34
  • 83.71 (n)
mouse
(Mus musculus)
Mammalia Nfkbid 34 16 35
  • 83.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFKBID 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFKBID 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFKBID 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFKBID 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfkbid 34
  • 61.73 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883232 34
  • 54.49 (n)
CT867948.1 35
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C33A11.1 35
  • 11 (a)
OneToMany
Species where no ortholog for NFKBID was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFKBID Gene

ENSEMBL:
Gene Tree for NFKBID (if available)
TreeFam:
Gene Tree for NFKBID (if available)

Paralogs for NFKBID Gene

Paralogs for NFKBID Gene

(1) SIMAP similar genes for NFKBID Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NFKBID: view

Variants for NFKBID Gene

Sequence variations from dbSNP and Humsavar for NFKBID Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10164327 -- 35,894,504(+) gagtt(C/T)gagac intron-variant
rs10401158 -- 35,897,461(+) ctggt(C/G)tcaaa intron-variant
rs10402798 -- 35,900,134(+) CTCGG(C/T)TGCCA intron-variant, upstream-variant-2KB
rs10407969 -- 35,890,962(+) cacca(C/T)gtctc intron-variant
rs10567511 -- 35,899,640(+) CCTTC(-/CT)CTCTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NFKBID Gene

Variant ID Type Subtype PubMed ID
dgv51n68 CNV loss 17160897

Variation tolerance for NFKBID Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFKBID Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFKBID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBID Gene

Disorders for NFKBID Gene

Relevant External Links for NFKBID

Human Genome Epidemiology (HuGE) Navigator
NFKBID
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFKBID

No disorders were found for NFKBID Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFKBID Gene

Publications for NFKBID Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. p100/II_BI' sequesters and inhibits NF-I_B through kappaBsome formation. (PMID: 25349408) Tao Z. … Ghosh G. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. T lymphocyte activation gene identification by coregulated expression on DNA microarrays. (PMID: 15177553) Mao M. … Linsley P.S. (Genomics 2004) 4 64

Products for NFKBID Gene

Sources for NFKBID Gene

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