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Aliases for NFKBID Gene

Aliases for NFKBID Gene

  • NFKB Inhibitor Delta 2 3
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Delta 2 3 5
  • T-Cell Activation NFKB-Like Protein 3 4
  • I-Kappa-B-Delta 3 4
  • IkappaBdelta 3 4
  • IkB-Delta 3 4
  • IkappaBNS 3 4
  • TA-NFKBH 3 4
  • NF-Kappa-B Inhibitor Delta 2
  • IKBNS 4

External Ids for NFKBID Gene

Previous GeneCards Identifiers for NFKBID Gene

  • GC19M041072
  • GC19M036379
  • GC19M032884
  • GC19M036382
  • GC19M036544
  • GC19M037063

Summaries for NFKBID Gene

GeneCards Summary for NFKBID Gene

NFKBID (NFKB Inhibitor Delta) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding. An important paralog of this gene is BCL3.

UniProtKB/Swiss-Prot for NFKBID Gene

  • May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBID Gene

Genomics for NFKBID Gene

Regulatory Elements for NFKBID Gene

Promoters for NFKBID Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NFKBID on UCSC Golden Path with GeneCards custom track

Genomic Location for NFKBID Gene

Chromosome:
19
Start:
35,887,129 bp from pter
End:
35,902,334 bp from pter
Size:
15,206 bases
Orientation:
Minus strand

Genomic View for NFKBID Gene

Genes around NFKBID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBID Gene

Proteins for NFKBID Gene

  • Protein details for NFKBID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI38-IKBD_HUMAN
    Recommended name:
    NF-kappa-B inhibitor delta
    Protein Accession:
    Q8NI38
    Secondary Accessions:
    • Q8NI39
    • Q9BRG9

    Protein attributes for NFKBID Gene

    Size:
    313 amino acids
    Molecular mass:
    33481 Da
    Quaternary structure:
    • Interacts with NFKB1, RELA and RELB; in the nucleus.

    Alternative splice isoforms for NFKBID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBID Gene

Proteomics data for NFKBID Gene at MOPED

Post-translational modifications for NFKBID Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFKBID Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for NFKBID

No data available for DME Specific Peptides for NFKBID Gene

Domains & Families for NFKBID Gene

Gene Families for NFKBID Gene

Protein Domains for NFKBID Gene

Suggested Antigen Peptide Sequences for NFKBID Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI38

UniProtKB/Swiss-Prot:

IKBD_HUMAN :
  • Belongs to the NF-kappa-B inhibitor family.
  • Contains 6 ANK repeats.
Family:
  • Belongs to the NF-kappa-B inhibitor family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with NFKBID: view

Function for NFKBID Gene

Molecular function for NFKBID Gene

UniProtKB/Swiss-Prot Function:
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).
genes like me logo Genes that share phenotypes with NFKBID: view

Animal Models for NFKBID Gene

MGI Knock Outs for NFKBID:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBID Gene

Localization for NFKBID Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBID Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFKBID Gene COMPARTMENTS Subcellular localization image for NFKBID gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NFKBID Gene

Pathways & Interactions for NFKBID Gene

SuperPathways for NFKBID Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA --
genes like me logo Genes that share ontologies with NFKBID: view

No data available for Pathways by source and SIGNOR curated interactions for NFKBID Gene

Drugs & Compounds for NFKBID Gene

No Compound Related Data Available

Transcripts for NFKBID Gene

Unigene Clusters for NFKBID Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBID Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8:
SP9: -
SP10: -

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NFKBID Gene

GeneLoc Exon Structure for
NFKBID
ECgene alternative splicing isoforms for
NFKBID

Expression for NFKBID Gene

mRNA expression in normal human tissues for NFKBID Gene

mRNA differential expression in normal tissues according to GTEx for NFKBID Gene

This gene is overexpressed in Whole Blood (x10.9).

SOURCE GeneReport for Unigene cluster for NFKBID Gene Hs.466531

genes like me logo Genes that share expression patterns with NFKBID: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NFKBID Gene

Orthologs for NFKBID Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBID 36
  • 67 (a)
OneToOne
NFKBID 35
  • 99.15 (n)
  • 99.68 (a)
cow
(Bos Taurus)
Mammalia NFKBID 35
  • 86.65 (n)
  • 89.42 (a)
NFKBID 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFKBID 36
  • 65 (a)
OneToOne
NFKBID 35
  • 87.93 (n)
  • 90.71 (a)
mouse
(Mus musculus)
Mammalia Nfkbid 16
Nfkbid 35
  • 83.6 (n)
  • 87.78 (a)
Nfkbid 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFKBID 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFKBID 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfkbid 35
  • 83.71 (n)
  • 89.07 (a)
chicken
(Gallus gallus)
Aves NFKBID 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFKBID 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfkbid 35
  • 61.73 (n)
  • 57.04 (a)
zebrafish
(Danio rerio)
Actinopterygii CT867948.1 36
  • 35 (a)
OneToOne
LOC101883232 35
  • 54.49 (n)
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea C33A11.1 36
  • 11 (a)
OneToMany
Species with no ortholog for NFKBID:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFKBID Gene

ENSEMBL:
Gene Tree for NFKBID (if available)
TreeFam:
Gene Tree for NFKBID (if available)

Paralogs for NFKBID Gene

Paralogs for NFKBID Gene

(1) SIMAP similar genes for NFKBID Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NFKBID: view

Variants for NFKBID Gene

Sequence variations from dbSNP and Humsavar for NFKBID Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8113704 - 35,896,979(+) GGGCC(A/G)CCTCC intron-variant, reference, missense, utr-variant-5-prime
rs7251744 -- 35,886,838(+) acagg(C/T)gcacg downstream-variant-500B
rs8104979 -- 35,891,852(+) acaga(A/G)tgaga intron-variant
rs10402798 -- 35,900,134(+) CTCGG(C/T)TGCCA intron-variant, upstream-variant-2KB
rs7253040 -- 35,899,439(+) AGGCG(C/G)CTGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NFKBID Gene

Variant ID Type Subtype PubMed ID
nsv911638 CNV Loss 21882294
dgv51n68 CNV Loss 17160897

Variation tolerance for NFKBID Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFKBID Gene

HapMap Linkage Disequilibrium report
NFKBID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBID Gene

Disorders for NFKBID Gene

Relevant External Links for NFKBID

Human Genome Epidemiology (HuGE) Navigator
NFKBID
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFKBID

No disorders were found for NFKBID Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFKBID Gene

Publications for NFKBID Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. p100/II_BI' sequesters and inhibits NF-I_B through kappaBsome formation. (PMID: 25349408) Tao Z. … Ghosh G. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for NFKBID Gene

Sources for NFKBID Gene

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