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Aliases for NFKBID Gene

Aliases for NFKBID Gene

  • NFKB Inhibitor Delta 2 3 5
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Delta 2 3
  • T-Cell Activation NFKB-Like Protein 3 4
  • NF-Kappa-B Inhibitor Delta 2 3
  • I-Kappa-B-Delta 3 4
  • IkappaBdelta 3 4
  • IkB-Delta 3 4
  • IkappaBNS 3 4
  • TA-NFKBH 3 4
  • IKBNS 4

External Ids for NFKBID Gene

Previous GeneCards Identifiers for NFKBID Gene

  • GC19M041072
  • GC19M036379
  • GC19M032884
  • GC19M036382
  • GC19M036544
  • GC19M037063

Summaries for NFKBID Gene

GeneCards Summary for NFKBID Gene

NFKBID (NFKB Inhibitor Delta) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include NF-kappaB binding. An important paralog of this gene is NFKBIZ.

UniProtKB/Swiss-Prot for NFKBID Gene

  • May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).

Additional gene information for NFKBID Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBID Gene

Genomics for NFKBID Gene

GeneHancer (GH) Regulatory Elements for NFKBID Gene

Promoters and enhancers for NFKBID Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035897 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570.7 -1.7 -1724 13 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZFP41 NFKBID TYROBP HCST ENSG00000280194 ZNF567 ZNF566 ZNF790 ZNF529 TMEM147-AS1 ZNF260
GH19I035435 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.3 +465.6 465601 2.7 HDAC1 BATF IRF4 YY1 ATF7 ETV6 FOS IKZF2 RUNX3 ZNF174 ZNF599 NFKBID TMEM147-AS1 FFAR2 LIN37 KRTDAP DMKN CD22 SBSN FAM187B
GH19I035430 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +471.1 471127 1.6 HDAC1 MEIS2 PKNOX1 ZNF280D MAFG ZNF518A ZNF610 HDAC2 ZNF169 ZNF548 NFKBID ZNF792 FFAR2 ZFP14 RBM42 TYROBP KMT2B KRTDAP DMKN HAUS5
GH19I035445 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +454.3 454294 4.7 PKNOX1 ATF1 BATF IRF4 ZNF354C ETV6 RUNX3 RXRA SMAD5 YY2 FFAR2 ZNF146 ZNF599 ZNF181 WTIP ZNF302 NFKBID TYROBP U2AF1L4 UPK1A
GH19I035461 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +439.4 439383 1.9 HDGF PKNOX1 SMAD1 ZNF493 ZFP64 IRF4 ZNF121 ZNF213 ATF7 KLF7 TMEM147-AS1 HAUS5 ZNF599 KMT2B PROSER3 RBM42 ZFP82 ZNF146 ZNF792 ZNF302
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NFKBID on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NFKBID gene promoter:

Genomic Locations for NFKBID Gene

Genomic Locations for NFKBID Gene
chr19:35,887,129-35,902,334
(GRCh38/hg38)
Size:
15,206 bases
Orientation:
Minus strand
chr19:36,378,555-36,393,205
(GRCh37/hg19)

Genomic View for NFKBID Gene

Genes around NFKBID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBID Gene

Proteins for NFKBID Gene

  • Protein details for NFKBID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI38-IKBD_HUMAN
    Recommended name:
    NF-kappa-B inhibitor delta
    Protein Accession:
    Q8NI38
    Secondary Accessions:
    • Q8NI39
    • Q9BRG9

    Protein attributes for NFKBID Gene

    Size:
    313 amino acids
    Molecular mass:
    33481 Da
    Quaternary structure:
    • Interacts with NFKB1, RELA and RELB; in the nucleus.

    Alternative splice isoforms for NFKBID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBID Gene

Post-translational modifications for NFKBID Gene

No Post-translational modifications

No data available for DME Specific Peptides for NFKBID Gene

Domains & Families for NFKBID Gene

Gene Families for NFKBID Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NFKBID Gene

Suggested Antigen Peptide Sequences for NFKBID Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI38

UniProtKB/Swiss-Prot:

IKBD_HUMAN :
  • Belongs to the NF-kappa-B inhibitor family.
Family:
  • Belongs to the NF-kappa-B inhibitor family.
genes like me logo Genes that share domains with NFKBID: view

Function for NFKBID Gene

Molecular function for NFKBID Gene

UniProtKB/Swiss-Prot Function:
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes (By similarity).

Gene Ontology (GO) - Molecular Function for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0051059 NF-kappaB binding IEA --
genes like me logo Genes that share ontologies with NFKBID: view
genes like me logo Genes that share phenotypes with NFKBID: view

Animal Models for NFKBID Gene

MGI Knock Outs for NFKBID:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFKBID Gene

Localization for NFKBID Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBID Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBID gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with NFKBID: view

Pathways & Interactions for NFKBID Gene

SuperPathways for NFKBID Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFKBID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006954 inflammatory response IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA --
GO:0033085 negative regulation of T cell differentiation in thymus IEA --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with NFKBID: view

No data available for Pathways by source and SIGNOR curated interactions for NFKBID Gene

Drugs & Compounds for NFKBID Gene

No Compound Related Data Available

Transcripts for NFKBID Gene

Unigene Clusters for NFKBID Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBID Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8:
SP9: -
SP10: -

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NFKBID Gene

GeneLoc Exon Structure for
NFKBID
ECgene alternative splicing isoforms for
NFKBID

Expression for NFKBID Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFKBID Gene

mRNA differential expression in normal tissues according to GTEx for NFKBID Gene

This gene is overexpressed in Whole Blood (x10.9).

NURSA nuclear receptor signaling pathways regulating expression of NFKBID Gene:

NFKBID

SOURCE GeneReport for Unigene cluster for NFKBID Gene:

Hs.466531

Evidence on tissue expression from TISSUES for NFKBID Gene

  • Blood(4.4)
genes like me logo Genes that share expression patterns with NFKBID: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKBID Gene

Orthologs for NFKBID Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBID 33 34
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia NFKBID 33 34
  • 87.93 (n)
cow
(Bos Taurus)
Mammalia NFKBID 33 34
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia Nfkbid 33
  • 83.71 (n)
mouse
(Mus musculus)
Mammalia Nfkbid 33 16 34
  • 83.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFKBID 34
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFKBID 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFKBID 34
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFKBID 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfkbid 33
  • 61.73 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883232 33
  • 54.49 (n)
CT867948.1 34
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C33A11.1 34
  • 11 (a)
OneToMany
Species where no ortholog for NFKBID was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFKBID Gene

ENSEMBL:
Gene Tree for NFKBID (if available)
TreeFam:
Gene Tree for NFKBID (if available)

Paralogs for NFKBID Gene

Paralogs for NFKBID Gene

(1) SIMAP similar genes for NFKBID Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NFKBID: view

Variants for NFKBID Gene

Sequence variations from dbSNP and Humsavar for NFKBID Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000000698 -- 35,889,120(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000269788 -- 35,894,633(-) G/A intron_variant
rs1000275515 -- 35,891,043(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000396552 -- 35,903,100(-) C/A upstream_transcript_variant
rs1000968616 -- 35,901,240(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NFKBID Gene

Variant ID Type Subtype PubMed ID
dgv51n68 CNV loss 17160897

Variation tolerance for NFKBID Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NFKBID Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFKBID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBID Gene

Disorders for NFKBID Gene

Additional Disease Information for NFKBID

No disorders were found for NFKBID Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFKBID Gene

Publications for NFKBID Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation. (PMID: 25349408) Tao Z … Ghosh G (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for NFKBID Gene

Sources for NFKBID Gene

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