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NFKBIB Gene

protein-coding   GIFtS: 69

GC19P044082
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for NFKBIB

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
I-kappa-B-beta 3
IKBB 1, 2, 3, 5
IkB-B 3
IkB-beta 3
IkappaBbeta 3
NF-kappa-BIB 3
TRIP-9 3
TRIP9 1, 2, 3, 5
Descriptions
TR-interacting protein 9 3
Thyroid receptor-interacting protein 9 3
nuclear factor of kappa light polypeptide gene enhancer in
B-cells inhibitor, beta 2
External Ids
HGNC: 77981
Entrez Gene: 47932
UniProtKB: Q156533
Ensembl: ENSG000001048257
Search outside databases for aliases for NFKBIB gene

Previous GC identifers: GC19P040002 GC19P039781 GC19P044066

Summaries
for NFKBIB

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for NFKBIB:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB
(MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins
(NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.
Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or
IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing
activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and
binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC
3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by
OMIM]

UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the
unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its
transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association
with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it
more resistant to degradation, explaining its slower degradation

Gene Wiki entry for NFKBIB

Genomic Location
for NFKBIB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NFKBIB gene  

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

NFKBIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044082:     (about GC identifiers)

Start:
 44,082,444 bp from pter
End:
 44,091,374 bp from pter
Size:
 8,931 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  

Proteins
for NFKBIB

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor beta  
Size: 356 amino acids; 37771 Da
Subunit: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts
with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q96BJ7
Alternative splicing: 2 isoforms:  Q15653-1   Q15653-2   

Post-translational modifications:

  • Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents
    phosphorylation1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001001716.1  NP_002494.2  


    ENSEMBL proteins: 
    ENSP00000386202 ENSP00000312988 ENSP00000375929 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (IKB beta)
    Human Recombinant Proteins from Abnova (NFKBIB)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol EXP10723127
    About this table

    Antibodies for NFKBIB: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NFKBIB
    R&D Systems Antibodies for NFKBIB (IkB-beta)
    Cell Signaling Technology (CST) Antibodies for NFKBIB  (IkBb)
    Antibodies from Abcam (IKB beta), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (NFKBIB)
    Novus Biologicals Antibodies for NFKBIB

    Assays for NFKBIB: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for NFKBIB

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR015681 NF_kB_inhbitor
     IPR002110 ANK


       GeneDecks  NFKBIB for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15653

    ProtoNet protein and cluster: Q15653

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
    Similarity: Belongs to the NF-kappa-B inhibitor family
    Similarity: Contains 6 ANK repeats

    Gene Function
    for NFKBIB

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (NFKBIB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NFKBIB)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002503

                  Applied Biosystems Silencer® siRNAs for NFKBIB

                  Sigma-Aldrich siRNA and siRNA Panels for NFKBIB  
                         Sigma-Aldrich shRNA Panels and shRNA for NFKBIB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for NFKBIB
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001716
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001716
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001001716 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002503

    UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
    Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the
    unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its
    transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association
    with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it
    more resistant to degradation, explaining its slower degradation

    Genatlas biochemistry entry for NFKBIB:
    nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor
    ar beta,sequestering it in the cytcytoplasm,also inhibiting NF-kappa B DNA binding

    1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nfkbib):

    normal

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713 transcription coactivator activity TAS7776974
    GO:0004871 signal transducer activity TAS7776974
    GO:0005515 protein binding IPI10498867 14743216
    About this table

    Pathways & Interactions
    for NFKBIB

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/33 Invitrogen iPath™ Online BioAtlas - Pathways for NFKBIB (see all 33 ) (Maps provided by GeneGo):
     IL4 signaling pathway
     A2BR signaling via G-alpha-q: PRKCB/G/Q specific pathways (map 3a)
     PDGF signaling via STATs and NF-kB
     TCR and CD28 co-stimulation in activation of NF-kB
     Signaling pathway mediated by IL-6 and IL-1

       GeneDecks  NFKBIB for the pathways selected above  
    About GeneDecksing

    5/38 Millipore Pathways for NFKBIB (see all 38 )
     Immune response MIF-mediated glucocorticoid regulation
     Immune response MIF in innate immunity response
     Immune response IL-1 signaling pathway
     Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
     Transcription NF-kB signaling pathway

       GeneDecks  NFKBIB for the pathways selected above  
    About GeneDecksing

    5/40 Sigma-Aldrich "Your Favorite Gene" Pathways for  NFKBIB  (Your Favorite Gene powered by Ingenuity) (see all 40 ) 
     Erythropoietin Signaling
     Hypoxia Signaling in the Cardiovascular System
     Angiopoietin Signaling
     PPAR Signaling
     Type II Diabetes Mellitus Signaling

       GeneDecks  NFKBIB for the pathways selected above  
    About GeneDecksing

    1 Cell Signaling Technology (CST) Pathway for NFKBIB: 
     T Cell Receptor Signaling

       GeneDecks  NFKBIB for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for NFKBIB):
     hsa04660 T cell receptor signaling pathway
     hsa04662 B cell receptor signaling pathway
     hsa04920 Adipocytokine signaling pathway

       GeneDecks  NFKBIB for the pathways selected above  
    About GeneDecksing

    5/78 Interacting proteins for NFKBIB (Q156531, 2 ENSP000003129883) via UniProtKB, MINT, and/or STRING (see all 78 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, ENSP000003370013MINT-47862 MINT-48582 MINT-48611 MINT-47920 MINT-48722 STRING (score=.93)
    NFKB1P198382, ENSP000002265743MINT-48542 MINT-48657 MINT-47861 MINT-47904 STRING (score=.952)
    CHUKO151112, ENSP000003594243MINT-47853 STRING (score=.999)
    IKBKBO149202, ENSP000003391513MINT-47854 STRING (score=.999)
    RELQ048642, ENSP000002950253MINT-47851 STRING (score=.999)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription TAS7776974
    GO:0007165 signal transduction TAS7776974
    About this table

    Drugs & Compounds
    for NFKBIB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for NFKBIB
    Browse Small Molecules at Sigma-Aldrich

    Compounds for NFKBIB available from Tocris Bioscience
    1 Novoseek chemical compound relationship for NFKBIB gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 0.00 2 11181838 (2)
    About this table


    Transcripts
    for NFKBIB

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (NFKBIB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NFKBIB)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002503

                  Sigma-Aldrich siRNA and siRNA Panels for NFKBIB  
                         Sigma-Aldrich shRNA Panels and shRNA for NFKBIB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001001716  NM_002503  

    REFSEQ mRNAs for NFKBIB gene (2 alternative transcripts): 

    NM_001001716.1   NM_002503.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001001716  NM_002503  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001716
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001716
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001001716 

    Additional cDNA sequence: 

    AB209784.1 AB362577.1 AK057862.1 AK290569.1 BC007197.1 BC015528.1 BT006743.1 CR592567.1 
    CR604980.1 CR618976.1 

    14 DOTS entries:

    DT.86855439  DT.313679  DT.100781872  DT.100777872  DT.91749442  DT.100777874  DT.121500124  DT.121500107 
    DT.121500144  DT.429673  DT.100029792  DT.100781874  DT.100059970  DT.75110752 

    24/176 AceView cDNA sequences (see all 176 ):

    CD366995 BM845555 CD672788 BM449613 BQ879409 BQ720355 CR618976 BC015528 
    BM560199 CR592567 BQ688190 AI191991 BU634404 R09289 CR604980 NM_002503 
    BQ896967 BM853672 BF448908 BM559687 BU855728 BU726634 BM761120 AA044256 

    highest scoring ESTs for NFKBIB:

    AA044140 AA261798 AA725591 AA769470 AA806371 AA825675 AA833886 AA847877 AA928200 AA953154 

    Unigene Cluster for NFKBIB:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
    Hs.9731  [show with all ESTs]
    Unigene Representative Sequence: NM_001001716


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIB

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7
    SP1:                                                                              
    SP2:        -     -     -                                                         
    SP3:                    -     -                                                   
    SP4:                          -                                                   

    About this scheme

    ECgene alternative splicing isoforms for NFKBIB

    3 Ensembl transcripts including schematic representations:
    ENST00000408917  ENST00000313582  ENST00000392079  

    Expression
    for NFKBIB

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NFKBIB expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NFKBIB

    1 / 2 / 3

    8 probe-sets matching NFKBIB gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		41065_at2, 3 U95-A 1 1.00 1.00 0.88 0.75 L40407 0.20 1.00 0.72 1

    		43069_at2, 3 U95-B 1 1.00 1.00 0.16 1.26 AA044140 0.80 1.00 0.91 1

    		228388_at2, 3 U133-B 1 1.00 1.00 -- -- AA044140 0.80 1.00 0.91 1

    		214062_x_at2, 3 U133-A 1 1.00 1.00 -- -- AI684894 0.80 1.00 0.91 1

    		214448_x_at2, 3 U133-A 1 0.91 1.00 -- -- NM_002503 0.60 1.00 0.82 1

    		228388_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		214062_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		214448_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGTGGTGGGC

    SOURCE GeneReport for Unigene cluster: Hs.9731

    Expression variation in blood from EXPOLDB for NFKBIB

    UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
    Tissue specificity: Expressed in all tissues examined

    Orthologs
    for NFKBIB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for NFKBIB gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 NFKBIB1   -- nuclear factor of kappa light polypeptide gene enhancer more 88.01(n)
    90.37(a)    		 484519  XM_541633.1  XP_541633.1 
    chimpanzee
    (Pan troglodytes)    		 NFKBIB1   -- nuclear factor of kappa light polypeptide gene enhancer more 98.88(n)
    99.16(a)    		 456014  XM_001168499.1  XP_001168499.1 
    cow
    (Bos taurus)    		 NFKBIB1   -- nuclear factor of kappa light polypeptide gene enhancer more 86.65(n)
    88.92(a)    		 525408  NM_001075872.1  NP_001069340.1 
    rat
    (Rattus norvegicus)    		 Nfkbib1   -- nuclear factor of kappa light polypeptide gene enhancer more 81.13(n)
    82.25(a)    		 81525  NM_030867.2  NP_110494.2 
    mouse
    (Mus musculus)    		 Nfkbib1, 5 75
    		 nuclear factor of kappa light polypeptide gene enhancer more1, 5 81.69(n)1
    84.79(a)1    		 180361  NM_010908.41  NP_035038.21 
     AI4133045  AK0102185  (see all 13)
    About this table        Species with no ortholog for NFKBIB

    ENSEMBL Gene Tree for NFKBIB

    Paralogs
    for NFKBIB

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for NFKBIB gene
    NFKBIA2  NFKBIE2  

    SNPs/Variants
    for NFKBIB

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/68 NCBI SNPs in NFKBIB are shown (see all 68 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 55)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs31366441,2
    		C,F,H,O44090471(+) CTCACA/GCTGCG 2 -- int1 ut3110Minor allele frequency- G:0.28NA NS EA EU 642
    rs31366451,2
    		C,F,H44090489(+) AACCTT/CGGGTG 2 -- ut31 int17Minor allele frequency- C:0.30NA NS EU EA WA 538
    rs31366421,2
    		A,C,F44090256(+) CAGGCA/GGCAGC 2 -- int1 ut313Minor allele frequency- G:0.45NA NS 126
    --
    rs178820621,2
    		F44090749(+) GGTGCG/AGTGGC 2 -- ut31 int11Minor allele frequency- A:0.10NS 48
    rs31366431,2
    		F44090315(+) GGAAGG/AGCTTG 2 -- ut31 int11Minor allele frequency- A:0.20NA 40
    rs31366401,2
    		C,F,H,O44088140(+) GCCCAG/CACATC 2 -- int114Minor allele frequency- C:0.37NA NS EU EA WA 1080
    rs110834871,2
    		A,C,F,H44089537(+) TGAGAT/CAGGCA 2 -- int15Minor allele frequency- C:0.11EU EA WA NS 458
    rs31366411,2
    		A,C,F,H44088489(+) CTCCCC/TTGCCT 2 -- int111Minor allele frequency- T:0.26NA EU EA WA NS 962
    rs22417051,2
    		A,C,F,H44088397(+) CCAGCA/CATGGG 2 -- int18Minor allele frequency- C:0.35EA NA NS EU WA 1826
    --
    rs110834841,2
    		A,C,F44084794(+) atccgC/Accgcc 2 -- int12Minor allele frequency- A:0.28NS 92
    About this table

    HapMap Linkage Disequilibrium images for NFKBIB (up to first 250kb)

    Disorders & Mutations
    for NFKBIB

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604495

    1 Novoseek disease relationship for NFKBIB gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 32.64 1 16792530 (1)
    About this table

    Human Genome Epidemiology Navigator: NFKBIB (3 documents)

    Medical News
    for NFKBIB

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for NFKBIB

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/91 PubMed articles for NFKBIB gene (see all 91 ):

    Search for NFKBIB

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Search String
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NFKBIB

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 4793 HGNC: 7798 AceView: NFKBIB Ensembl:ENSG00000104825 euGenes: HUgn4793
    ECgene: NFKBIB H-InvDB: NFKBIB

    Other Databases showing NFKBIB

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing NFKBIB

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for NFKBIB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/nfkbib/

    Licensable Technologies
    for NFKBIB

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for NFKBIB

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NFKBIB:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NFKBIB-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NFKBIB Antibodies for NFKBIB
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NFKBIB Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (NFKBIB)
     Antibodies (NFKBIB)
     Chimera RNAi (NFKBIB)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for NFKBIB  (IkBb)

     Recombinant Proteins
    (IKB beta)
     Antibodies (IKB beta)
     Search OriGene for NFKBIB
     Tocris compounds for NFKBIB




     Drugs for NFKBIB
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for NFKBIB

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

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    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    NFKBIB Gene at Home site.
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