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NFKBIB Gene

protein-coding   GIFtS: 65
GCID: GC19P039390

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
Inhibitor, Beta1 2
     ikB-B2
IKBB2 3 5     ikB-beta2
TRIP92 3 5     ikappaBbeta2
Thyroid Receptor-Interacting Protein 92 3     NF-Kappa-B Inhibitor Beta2
I-kappa-B-beta2 3     IkB-B3
NF-kappa-BIB2 3     IkB-beta3
TRIP-92 3     IkappaBbeta3
TR-Interacting Protein 92 3     

External Ids:    HGNC: 77981   Entrez Gene: 47932   Ensembl: ENSG000001048257   OMIM: 6044955   UniProtKB: Q156533   
ORGUL members:         

Export aliases for NFKBIB gene to outside databases

Previous GC identifers: GC19P040002 GC19P039781 GC19P044066 GC19P044082 GC19P035837


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFKBIB Gene:
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by
complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by
kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B,
which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript
variants have been found for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for NFKBIB Gene:
NFKBIB (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta) is a protein-coding gene. Diseases associated with NFKBIB include shigellosis, and toxoplasmosis. GO annotations related to this gene include transcription coactivator activity and signal transducer activity. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated
form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and
protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1
and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower
degradation

Gene Wiki entry for NFKBIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFKBIB gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFKBIB promoter sequence
   Search Chromatin IP Primers for NFKBIB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFKBIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

NFKBIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039390:  view genomic region     (about GC identifiers)

Start:
39,390,340 bp from pter      End:
39,399,534 bp from pter
Size:
9,195 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor beta  
Size: 356 amino acids; 37771 Da
Subunit: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and
inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2
Secondary accessions: A8K3F4 Q96BJ7
Alternative splicing: 2 isoforms:  Q15653-1   Q15653-2   

Explore the universe of human proteins at neXtProt for NFKBIB: NX_Q15653

Explore proteomics data for NFKBIB at MOPED

Post-translational modifications: 

  • Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents
    phosphorylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFKBIB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230045.1  NP_002494.2  

    ENSEMBL proteins: 
     ENSP00000461617   ENSP00000459728   ENSP00000458685   ENSP00000438598   ENSP00000312988  
     ENSP00000375929  
    Reactome Protein details: Q15653

    NFKBIB Human Recombinant Protein Products:

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    Novus Biologicals NFKBIB Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NFKBIB
    Browse Proteins at Cloud-Clone Corp.

    NFKBIB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NFKBIB
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    ThermoFisher Antibodies for NFKBIB
    LSBio Antibodies in human, mouse, rat for NFKBIB

    NFKBIB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q15653

    ProtoNet protein and cluster: Q15653

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
    Similarity: Belongs to the NF-kappa-B inhibitor family
    Similarity: Contains 6 ANK repeats


    NFKBIB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKBB_HUMAN, Q15653
    Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated
    form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and
    protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1
    and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower
    degradation

         Genatlas biochemistry entry for NFKBIB:
    nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor ar
    beta,sequestering it in the cytcytoplasm,also inhibiting NF-kappa B DNA binding

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS7776974
    GO:0004871signal transducer activity TAS7776974
    GO:0005515protein binding IPI10498867
         
    NFKBIB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NFKBIB:
     Decreased Hepatitis C virus re  Increased cell number in S 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nfkbib):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  normal 
     skeleton 

    NFKBIB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NFKBIB: Nfkbibtm1Bal Nfkbibtm1Jpmz Nfkbibtm1.2Rsch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFKBIB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFKBIB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFKBIB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFKBIB

    miRNA
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    Block miRNA regulation of human, mouse, rat NFKBIB using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NFKBIB:
    hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFKBIB
    Predesigned siRNA for gene silencing in human, mouse, rat NFKBIB

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): NFKBIB (NM_002503)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKBIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKBB_HUMAN, Q15653: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    NFKBIB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NFKBIB About   (see all 67)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    GITR Pathway0.46
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    TWEAK Signaling Pathway0.31
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    3Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    4IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    IL17 signaling pathway0.51
    5Cytosolic sensors of pathogen-associated DNA
    RIP-mediated NFkB activation via ZBP10.81
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex0.52
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Cytosolic sensors of pathogen-associated DNA0.38
    TRAF6 mediated NF-kB activation0.55
    Cytosolic DNA-sensing pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for NFKBIB (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NFKBIB (see all 57)
        TWEAK Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling

    1 Cell Signaling Technology (CST) Pathway for NFKBIB
        NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for NFKBIB (see all 46)
        Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for NFKBIB (see all 6)
        Apoptosis
    TNF-alpha/NF-kB Signaling Pathway
    IL17 signaling pathway
    TWEAK Signaling Pathway
    Prolactin Signaling Pathway

    4 Reactome Pathways for NFKBIB
        RIP-mediated NFkB activation via ZBP1
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex
    Activation of NF-kappaB in B cells
    TRAF6 mediated NF-kB activation


    Selected Kegg Pathways  (Kegg details for NFKBIB) (see all 15):
        Chemokine signaling pathway
    NOD-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    T cell receptor signaling pathway


    NFKBIB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFKBIB: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NFKBIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFKBIB (Q156531, 2, 3 ENSP000003129884) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3, ENSP000001894444MINT-47862 MINT-48582 MINT-48611 MINT-47920 MINT-48722 I2D: score=4 STRING: ENSP00000189444
    NFKB1P198382, 3, ENSP000002265744MINT-48542 MINT-48657 MINT-47861 MINT-47904 I2D: score=4 STRING: ENSP00000226574
    CHUKO151112, 3, ENSP000003594244MINT-47853 I2D: score=6 STRING: ENSP00000359424
    LRPPRCP427042, 3, ENSP000002606654MINT-47858 I2D: score=4 STRING: ENSP00000260665
    SKP1P632082, 3, ENSP000002314874MINT-47873 I2D: score=2 STRING: ENSP00000231487
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006351transcription, DNA-templated TAS7776974
    GO:0007165signal transduction TAS7776974

    NFKBIB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFKBIB (IKBB)

    5 Novoseek inferred chemical compound relationships for NFKBIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paclitaxel 10.1 2 12226754 (1)
    aspirin 1.37 2 14753751 (1)
    potassium 0 2 11181838 (2)
    serine 0 2 12672800 (1), 9092533 (1)
    h2o2 0 1 14753751 (1)



    NFKBIB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NFKBIB gene (3 alternative transcripts): 
    NM_001243116.1  NM_002503.4  NM_001001716.1  

    Unigene Cluster for NFKBIB:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
    Hs.9731  [show with all ESTs]
    Unigene Representative Sequence: NR_040515
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576510 ENST00000572515 ENST00000575359 ENST00000509705 ENST00000313582(uc010egk.2 uc002ojw.3)
    ENST00000392079(uc002ojx.3 uc002ojy.3)
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): NFKBIB (NM_002503)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIB
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NFKBIB
      QuantiFast Probe-based Assays in human, mouse, rat NFKBIB

    Additional mRNA sequence: 

    AB209784.1 AB362577.1 AK057862.1 AK290569.1 BC007197.1 BC015528.1 BT006743.1 NR_040515.1 

    14 DOTS entries:

    DT.86855439  DT.313679  DT.100781872  DT.100777872  DT.91749442  DT.100777874  DT.121500124  DT.121500107 
    DT.121500144  DT.429673  DT.100029792  DT.100781874  DT.100059970  DT.75110752 

    Selected AceView cDNA sequences (see all 176):

    BM560199 BM559687 BU634404 CR618976 BM449613 BQ879409 BC007197 BC015528 
    R09289 AI191991 CR604980 BM761120 BI520169 AA044256 CD366995 BU726634 
    BM845555 BQ435098 BF448908 BQ720355 BU855728 NM_001001716 BQ896967 BQ688190 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIB    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7
    SP1:                                                                              
    SP2:        -     -     -                                                         
    SP3:                    -     -                                                   
    SP4:                          -                                                   


    ECgene alternative splicing isoforms for NFKBIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NFKBIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NFKBIB Expression
    About this image


    NFKBIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    NFKBIB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFKBIB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9731

    UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
    Tissue specificity: Expressed in all tissues examined

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFKBIB: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NFKBIB
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NFKBIB gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfkbib1 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 80.66(n)1
    83.1(a)1
      7 (16.91 cM)5
    180361  NM_010908.41  NP_035038.21 
     287582515 
    chicken
    (Gallus gallus)
    Aves NFKBIB1 nuclear factor of kappa light polypeptide gene enhancer more 63.31(n)
    60.89(a)
      100858419  XM_003643504.2  XP_003643552.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFKBIB6
    nuclear factor of kappa light polypeptide gene enh...
    52(a)
    1 ↔ 1
    GL343885.1(30314-36484)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-110c7.11 si:dkeyp-110c7.1 50.64(n)
    43.4(a)
      797834  NM_001128795.1  NP_001122267.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cact6
    cactus
    17(a)
    1 → many
    2L(16313029-16326101)


    ENSEMBL Gene Tree for NFKBIB (if available)
    TreeFam Gene Tree for NFKBIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFKBIB gene
    NFKBID2  NFKBIA2  NFKBIE2  BCL32  NFKBIZ2  
    1 SIMAP similar gene for NFKBIB using alignment to 5 protein entries:     IKBB_HUMAN (see all proteins):
    RAI14

    NFKBIB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFKBIB (see all 363)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs582497491,2
    C--39394746(+) AAATA-/AATAA 
     ATAAATA
    TTCTT
    3 -- int11Minor allele frequency- AATAAATAAATA:0.00NA 2
    rs178804521,2
    C,F--39395120(+) ACTCT-/CTT   
      T
    /TCTT
    GTTTT
    3 -- int13NS NA 96
    rs664661471,2
    C--39395390(+) GACTCTTGT/-  
            
    TTGTT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs178833921,2
    C,F--39395392(+) TGTTT-/GTTT  
            
    CACGT
    3 -- int13Minor allele frequency- GTTT:0.36NS NA 94
    rs113006701,2
    C--39396772(+) TTTTTT/-TTTTT 3 -- int1 trp32Minor allele frequency- -:0.25NA 4
    rs592865581,2
    C--39397107(+) TTTTT-/TGACAT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs1902403211,2
    --39538033(+) GAGGTA/GGGGGC 1 -- us2k10--------
    rs1925785221,2
    --39538081(+) CTCAAA/GCGATC 1 -- us2k10--------
    rs1466632131,2
    --39538101(+) CAGCCG/TCCCAA 1 -- us2k10--------
    rs31366391,2
    C,F--39538162(+) CTTTCT/ATTTTT 1 -- us2k1 trp38Minor allele frequency- A:0.29NA WA CSA EA 405

    HapMap Linkage Disequilibrium report for NFKBIB (39390340 - 39399534 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NFKBIB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718539CNV Deletion23290073
    esv3793CNV Deletion18987735
    esv2414967CNV Deletion18987734
    esv2718538CNV Deletion23290073
    nsv911676CNV Loss21882294
    nsv911674CNV Loss21882294
    nsv911677CNV Loss21882294
    nsv911675CNV Gain21882294
    nsv820174CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604495    OMIM disorders: --

    Selected diseases for NFKBIB (see all 27):    
    About MalaCards
    shigellosis    toxoplasmosis    human t-cell leukemia virus type 1    thyroiditis
    measles    leishmaniasis    t-cell leukemia    endometrial carcinoma
    lymphoblastic leukemia    hepatitis c virus    influenza    hiv-1
    renal cell carcinoma    hepatitis c    atherosclerosis    herpes simplex
    obesity    endotheliitis    leukemia    rheumatoid arthritis


    NFKBIB for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NFKBIB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 36 1 16792530 (1)

    Genetic Association Database (GAD): NFKBIB
    Human Genome Epidemiology (HuGE) Navigator: NFKBIB (18 documents)

    Export disorders for NFKBIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFKBIB gene, integrated from 10 sources (see all 120):
    (articles sorted by number of sources associating them with NFKBIB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)1, 2, 9 Chen Y.... Ghosh G. (Mol. Cell. Biol. 2004)
    2. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PubMed id 12672800)1, 2, 9 Chen Y.... Ghosh G. (J. Biol. Chem. 2003)
    3. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 9 Fenwick C....Ghosh S. (Science 2000)
    4. Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. (PubMed id 9763672)1, 3, 9 Okamoto T....Sonta S. (Cytogenet. Cell Genet. 1998)
    5. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    6. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. (PubMed id 20448286)1, 4 Potter C....Isaacs J.D. (Ann. Rheum. Dis. 2010)
    7. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    8. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    9. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    10. Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia. (PubMed id 20716621)1, 4 Chang J.S....Buffler P.A. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4793 HGNC: 7798 AceView: NFKBIB Ensembl:ENSG00000104825 euGenes: HUgn4793
    ECgene: NFKBIB Kegg: 4793 H-InvDB: NFKBIB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NFKBIB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFKBIB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/nfkbib/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFKBIB gene:
    Search GeneIP for patents involving NFKBIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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