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Aliases for NFKBIB Gene

Aliases for NFKBIB Gene

  • NFKB Inhibitor Beta 2 3
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta 2 3 5
  • Thyroid Receptor-Interacting Protein 9 3 4
  • TR-Interacting Protein 9 3 4
  • I-Kappa-B-Beta 3 4
  • NF-Kappa-BIB 3 4
  • IkappaBbeta 3 4
  • IkB-Beta 3 4
  • TRIP-9 3 4
  • IkB-B 3 4
  • TRIP9 3 4
  • IKBB 3 4
  • NF-Kappa-B Inhibitor Beta 2

External Ids for NFKBIB Gene

Previous GeneCards Identifiers for NFKBIB Gene

  • GC19P040002
  • GC19P039781
  • GC19P044066
  • GC19P044082
  • GC19P039390
  • GC19P035837

Summaries for NFKBIB Gene

Entrez Gene Summary for NFKBIB Gene

  • The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for NFKBIB Gene

NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include signal transducer activity and transcription coactivator activity. An important paralog of this gene is BCL3.

UniProtKB/Swiss-Prot for NFKBIB Gene

  • Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Gene Wiki entry for NFKBIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIB Gene

Genomics for NFKBIB Gene

Regulatory Elements for NFKBIB Gene

Promoters for NFKBIB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NFKBIB on UCSC Golden Path with GeneCards custom track

Genomic Location for NFKBIB Gene

Chromosome:
19
Start:
38,899,657 bp from pter
End:
38,908,894 bp from pter
Size:
9,238 bases
Orientation:
Plus strand

Genomic View for NFKBIB Gene

Genes around NFKBIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIB Gene

Proteins for NFKBIB Gene

  • Protein details for NFKBIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15653-IKBB_HUMAN
    Recommended name:
    NF-kappa-B inhibitor beta
    Protein Accession:
    Q15653
    Secondary Accessions:
    • A8K3F4
    • Q96BJ7

    Protein attributes for NFKBIB Gene

    Size:
    356 amino acids
    Molecular mass:
    37771 Da
    Quaternary structure:
    • Interacts with THRB (via ligand-binding domain) (PubMed:7776974). Interacts with RELA and REL (By similarity). Interacts with COMMD1 (PubMed:16573520). Interacts with inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2 (PubMed:10657303, PubMed:12672800, PubMed:15024091). Interacts with DDRGK1; positively regulates NFKBIB phosphorylation and degradation (PubMed:23675531).

    Alternative splice isoforms for NFKBIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBIB Gene

Proteomics data for NFKBIB Gene at MOPED

Post-translational modifications for NFKBIB Gene

  • Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFKBIB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NFKBIB (IkB-beta)
  • Cloud-Clone Corp. Antibodies for NFKBIB

No data available for DME Specific Peptides for NFKBIB Gene

Domains & Families for NFKBIB Gene

Gene Families for NFKBIB Gene

Protein Domains for NFKBIB Gene

Suggested Antigen Peptide Sequences for NFKBIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15653

UniProtKB/Swiss-Prot:

IKBB_HUMAN :
  • Belongs to the NF-kappa-B inhibitor family.
  • Contains 6 ANK repeats.
Family:
  • Belongs to the NF-kappa-B inhibitor family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with NFKBIB: view

Function for NFKBIB Gene

Molecular function for NFKBIB Gene

GENATLAS Biochemistry:
nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor ar beta,sequestering it in the cytcytoplasm,also inhibiting NF-kappa B DNA binding
UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
genes like me logo Genes that share phenotypes with NFKBIB: view

Animal Models for NFKBIB Gene

MGI Knock Outs for NFKBIB:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NFKBIB Gene

Localization for NFKBIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIB Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFKBIB Gene COMPARTMENTS Subcellular localization image for NFKBIB gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for NFKBIB Gene

Pathways & Interactions for NFKBIB Gene

SuperPathways for NFKBIB Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 TWEAK Pathway
3 4-1BB Pathway
4 Cytosolic sensors of pathogen-associated DNA
5 Toll-Like receptor Signaling Pathways
genes like me logo Genes that share pathways with NFKBIB: view

SIGNOR curated interactions for NFKBIB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NFKBIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006351 transcription, DNA-templated TAS 7776974
GO:0007165 signal transduction IEA --
GO:0007253 cytoplasmic sequestering of NF-kappaB IEA --
genes like me logo Genes that share ontologies with NFKBIB: view

Drugs & Compounds for NFKBIB Gene

(4) Drugs for NFKBIB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NFKBIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFKBIB: view

Transcripts for NFKBIB Gene

Unigene Clusters for NFKBIB Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIB Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NFKBIB Gene

GeneLoc Exon Structure for
NFKBIB
ECgene alternative splicing isoforms for
NFKBIB

Expression for NFKBIB Gene

mRNA expression in normal human tissues for NFKBIB Gene

Protein differential expression in normal tissues from HIPED for NFKBIB Gene

This gene is overexpressed in Blymphocyte (15.4), Peripheral blood mononuclear cells (14.4), and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NFKBIB Gene



SOURCE GeneReport for Unigene cluster for NFKBIB Gene Hs.9731

mRNA Expression by UniProt/SwissProt for NFKBIB Gene

Q15653-IKBB_HUMAN
Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expression patterns with NFKBIB: view

Protein tissue co-expression partners for NFKBIB Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NFKBIB Gene

Orthologs for NFKBIB Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBIB 35
  • 98.88 (n)
  • 99.16 (a)
NFKBIB 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFKBIB 36
  • 88 (a)
OneToOne
NFKBIB 35
  • 86.65 (n)
  • 88.92 (a)
dog
(Canis familiaris)
Mammalia NFKBIB 35
  • 88.01 (n)
  • 90.37 (a)
NFKBIB 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfkbib 16
Nfkbib 35
  • 80.66 (n)
  • 83.1 (a)
Nfkbib 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFKBIB 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nfkbib 35
  • 80.19 (n)
  • 80.85 (a)
chicken
(Gallus gallus)
Aves NFKBIB 35
  • 63.31 (n)
  • 60.89 (a)
lizard
(Anolis carolinensis)
Reptilia NFKBIB 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NFKBIB 36
  • 29 (a)
OneToOne
si:dkeyp-110c7.1 35
  • 50.64 (n)
  • 43.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta cact 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for NFKBIB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFKBIB Gene

ENSEMBL:
Gene Tree for NFKBIB (if available)
TreeFam:
Gene Tree for NFKBIB (if available)

Paralogs for NFKBIB Gene

Paralogs for NFKBIB Gene

(1) SIMAP similar genes for NFKBIB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFKBIB: view

Variants for NFKBIB Gene

Sequence variations from dbSNP and Humsavar for NFKBIB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_020771 -
rs2241705 -- 38,905,917(+) CCAGC(A/C)ATGGG intron-variant
rs4803013 -- 38,903,346(+) tggca(C/T)gatct intron-variant
rs8104364 -- 38,903,531(+) gatct(A/G)cccgc intron-variant
rs8104984 -- 38,904,000(+) aggag(A/G)tggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFKBIB Gene

Variant ID Type Subtype PubMed ID
nsv911674 CNV Loss 21882294
esv2718538 CNV Deletion 23290073
esv2414967 CNV Deletion 18987734
esv3793 CNV Deletion 18987735
esv2718539 CNV Deletion 23290073
nsv911675 CNV Gain 21882294
nsv911676 CNV Loss 21882294
nsv911677 CNV Loss 21882294
nsv820174 CNV Gain 19587683

Variation tolerance for NFKBIB Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFKBIB Gene

HapMap Linkage Disequilibrium report
NFKBIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIB Gene

Disorders for NFKBIB Gene

Relevant External Links for NFKBIB

Genetic Association Database (GAD)
NFKBIB
Human Genome Epidemiology (HuGE) Navigator
NFKBIB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFKBIB

No disorders were found for NFKBIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFKBIB Gene

Publications for NFKBIB Gene

  1. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PMID: 15024091) Chen Y. … Ghosh G. (Mol. Cell. Biol. 2004) 3 4 23 67
  2. Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. (PMID: 9763672) Okamoto T. … Sonta S. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 23
  4. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. (PMID: 18356846) Sheu W.H. … Lee I.T. (Obesity (Silver Spring) 2008) 3 23
  5. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PMID: 12672800) Chen Y. … Ghosh G. (J. Biol. Chem. 2003) 3 23

Products for NFKBIB Gene

Sources for NFKBIB Gene

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