Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFKBIB Gene

protein-coding   GIFtS: 66
GCID: GC19P039390

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
Inhibitor, Beta1 2
     ikB-B2
IKBB2 3 5     ikB-beta2
TRIP92 3 5     ikappaBbeta2
Thyroid Receptor-Interacting Protein 92 3     NF-Kappa-B Inhibitor Beta2
I-kappa-B-beta2 3     IkB-B3
NF-kappa-BIB2 3     IkB-beta3
TRIP-92 3     IkappaBbeta3
TR-Interacting Protein 92 3     

External Ids:    HGNC: 77981   Entrez Gene: 47932   Ensembl: ENSG000001048257   OMIM: 6044955   UniProtKB: Q156533   
ORGUL members:         
NONCODE14:n411675      

Export aliases for NFKBIB gene to outside databases

Previous GC identifers: GC19P040002 GC19P039781 GC19P044066 GC19P044082 GC19P035837


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFKBIB Gene:
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by
complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by
kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B,
which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript
variants have been found for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for NFKBIB Gene: 
NFKBIB (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NFKBIB include shigellosis, and toxoplasmosis, and among its related super-pathways are DR3 Signaling and Signal transduction AKT signaling. GO annotations related to this gene include transcription coactivator activity and signal transducer activity. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated
form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and
protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1
and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower
degradation

Gene Wiki entry for NFKBIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFKBIB gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFKBIB promoter sequence
   Search SABiosciences Chromatin IP Primers for NFKBIB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

NFKBIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039390:  view genomic region     (about GC identifiers)

Start:
39,390,340 bp from pter      End:
39,399,534 bp from pter
Size:
9,195 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor beta  
Size: 356 amino acids; 37771 Da
Subunit: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and
inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: A8K3F4 Q96BJ7
Alternative splicing: 2 isoforms:  Q15653-1   Q15653-2   

Explore the universe of human proteins at neXtProt for NFKBIB: NX_Q15653

Explore proteomics data for NFKBIB at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents
    phosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15653

  • NFKBIB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NFKBIB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230045.1  NP_002494.2  

    ENSEMBL proteins: 
     ENSP00000461617   ENSP00000459728   ENSP00000458685   ENSP00000438598   ENSP00000312988  
     ENSP00000375929  
    Reactome Protein details: Q15653
    Human Recombinant Protein Products for NFKBIB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NFKBIB
    OriGene Protein Over-expression Lysate for NFKBIB
    OriGene MassSpec for NFKBIB 
    OriGene Custom Protein Services for NFKBIB
    GenScript Custom Purified and Recombinant Proteins Services for NFKBIB
    Novus Biologicals NFKBIB Proteins
    Novus Biologicals NFKBIB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NFKBIB
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    NFKBIB for ontologies           About GeneDecksing



    NFKBIB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NFKBIB (IkB-beta)
    Cell Signaling Technology (CST) Antibodies for NFKBIB  (IkB-beta)
    OriGene Antibodies for NFKBIB
    OriGene Custom Antibody Services for NFKBIB
    GenScript Custom Superior Antibodies Services for NFKBIB
    Novus Biologicals NFKBIB Antibodies
    Abcam antibodies for NFKBIB
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for NFKBIB
    LSBio Antibodies in human, mouse, rat for NFKBIB 

    Assay Products for NFKBIB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFKBIB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFKBIB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q15653

    ProtoNet protein and cluster: Q15653

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
    Similarity: Belongs to the NF-kappa-B inhibitor family
    Similarity: Contains 6 ANK repeats


    NFKBIB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKBB_HUMAN, Q15653
    Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated
    form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and
    protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1
    and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower
    degradation

         Genatlas biochemistry entry for NFKBIB:
    nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor ar
    beta,sequestering it in the cytcytoplasm,also inhibiting NF-kappa B DNA binding

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS7776974
    GO:0004871signal transducer activity TAS7776974
    GO:0005515protein binding IPI10498867
         
    NFKBIB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NFKBIB:
     Decreased Hepatitis C virus re  Increased cell number in S 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nfkbib):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  normal 
     skeleton 

    NFKBIB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NFKBIB: Nfkbibtm1Bal Nfkbibtm1Jpmz Nfkbibtm1.2Rsch

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NFKBIB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFKBIB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFKBIB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFKBIB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFKBIB
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NFKBIB:
    hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NFKBIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFKBIB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFKBIB
    Sirion Biotech Customized adenovirus for overexpression of NFKBIB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NFKBIB (see all 14)
    OriGene ORF clones in mouse, rat for NFKBIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFKBIB (NM_002503)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKBIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIB
    Sirion Biotech Customized lentivirus for stable overexpression of NFKBIB 
                         Customized lentivirus expression plasmids for stable overexpression of NFKBIB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFKBIB
    Search LifeMap BioReagents cell lines for NFKBIB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NFKBIB About   (see all 73)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    GITR Pathway0.46
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    TWEAK Signaling Pathway0.31
    2Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    Immune response IL-1 signaling pathway0.41
    TLR-TRIF Pathway0.61
    IL-1 Pathway0.39
    Immune response MIF in innate immunity response0.46
    iNOS Signaling0.34
    4RIP-mediated NFkB activation via ZBP1
    RIP-mediated NFkB activation via ZBP10.85
    Activation of NF-KappaB by PKR0.33
    ZBP1(DAI) mediated induction of type I IFNs0.85
    Cellular Transformation by HTLV10.31
    TRAF6 mediated NF-kB activation0.42
    5BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/38 EMD Millipore Pathways for NFKBIB (see all 38)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Transcription NF-kB signaling pathway

    5 R&D Systems Pathways for NFKBIB
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/57 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFKBIB (see all 57)
        TWEAK Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling

    1 Cell Signaling Technology (CST) Pathway for NFKBIB
        NF-kappaB Signaling

    5/46 GeneGo (Thomson Reuters) Pathways for NFKBIB (see all 46)
        Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    5 BioSystems Pathways for NFKBIB
        Apoptosis
    TNF-alpha/NF-kB Signaling Pathway
    TWEAK Signaling Pathway
    Prolactin Signaling Pathway
    BCR signaling pathway

    5/30        Reactome Pathways for NFKBIB (see all 30)
        Toll Like Receptor 2 (TLR2) Cascade
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    5/15         Kegg Pathways  (Kegg details for NFKBIB) (see all 15):
        Chemokine signaling pathway
    NOD-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    T cell receptor signaling pathway


    NFKBIB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NFKBIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for NFKBIB (Q156531, 2, 3 ENSP000003129884) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3, ENSP000001894444MINT-47862 MINT-48582 MINT-48611 MINT-47920 MINT-48722 I2D: score=4 STRING: ENSP00000189444
    NFKB1P198382, 3, ENSP000002265744MINT-48542 MINT-48657 MINT-47861 MINT-47904 I2D: score=4 STRING: ENSP00000226574
    CHUKO151112, 3, ENSP000003594244MINT-47853 I2D: score=6 STRING: ENSP00000359424
    LRPPRCP427042, 3, ENSP000002606654MINT-47858 I2D: score=4 STRING: ENSP00000260665
    POLR1EQ9GZS12, 3, ENSP000003670294MINT-47864 I2D: score=3 STRING: ENSP00000367029
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006351transcription, DNA-dependent TAS7776974
    GO:0007165signal transduction TAS7776974

    NFKBIB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NFKBIB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFKBIB (IKBB)

    5 Novoseek inferred chemical compound relationships for NFKBIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paclitaxel 10.1 2 12226754 (1)
    aspirin 1.37 2 14753751 (1)
    potassium 0 2 11181838 (2)
    serine 0 2 12672800 (1), 9092533 (1)
    h2o2 0 1 14753751 (1)

    Search CenterWatch for drugs/clinical trials and news about NFKBIB / IKBB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFKBIB gene (3 alternative transcripts): 
    NM_001243116.1  NM_002503.4  NM_001001716.1  

    Unigene Cluster for NFKBIB:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
    Hs.9731  [show with all ESTs]
    Unigene Representative Sequence: NR_040515
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576510 ENST00000572515 ENST00000575359 ENST00000509705 ENST00000313582(uc010egk.2 uc002ojw.3)
    ENST00000392079(uc002ojx.3 uc002ojy.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFKBIB
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NFKBIB:
    hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NFKBIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFKBIB
    Clone
    Products:
         
    OriGene clones in human, mouse for NFKBIB (see all 14)
    OriGene ORF clones in mouse, rat for NFKBIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFKBIB (NM_002503)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKBIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIB
    Sirion Biotech Customized lentivirus for stable overexpression of NFKBIB 
                         Customized lentivirus expression plasmids for stable overexpression of NFKBIB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFKBIB
    OriGene qSTAR qPCR primer pairs in human, mouse for NFKBIB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFKBIB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFKBIB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFKBIB

    Additional mRNA sequence: 

    AB209784.1 AB362577.1 AK057862.1 AK290569.1 BC007197.1 BC015528.1 BT006743.1 NR_040515.1 

    14 DOTS entries:

    DT.86855439  DT.313679  DT.100781872  DT.100777872  DT.91749442  DT.100777874  DT.121500124  DT.121500107 
    DT.121500144  DT.429673  DT.100029792  DT.100781874  DT.100059970  DT.75110752 

    24/176 AceView cDNA sequences (see all 176):

    CR618976 BF448908 AI633903 NM_002503 BQ435098 BM559687 BQ896967 AI191991 
    CD672788 BM560199 CD366995 AA044256 BM761120 BU145500 BQ436052 BM845555 
    BU634404 BQ879409 BQ720355 BQ688190 NM_001001716 R09289 CR592567 BC007197 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIB    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7
    SP1:                                                                              
    SP2:        -     -     -                                                         
    SP3:                    -     -                                                   
    SP4:                          -                                                   


    ECgene alternative splicing isoforms for NFKBIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFKBIB expression in normal human tissues (normalized intensities)      NFKBIB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NFKBIB Expression
    About this image


    NFKBIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See NFKBIB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFKBIB

    SOURCE GeneReport for Unigene cluster: Hs.9731

    UniProtKB/Swiss-Prot: IKBB_HUMAN, Q15653
    Tissue specificity: Expressed in all tissues examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including NFKBIB: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFKBIB
    OriGene qSTAR qPCR primer pairs in human, mouse for NFKBIB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFKBIB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFKBIB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFKBIB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NFKBIB gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfkbib1 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 81.69(n)1
    84.79(a)1
      7 (16.91 cM)5
    180361  NM_010908.41  NP_035038.21 
     287582515 
    chicken
    (Gallus gallus)
    Aves LOC1008584191 NF-kappa-B inhibitor beta-like 63.5(n)
    62.57(a)
      100858419  XM_003643504.1  XP_003643552.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFKBIB6
    Uncharacterized protein
    52(a)
    1 ↔ 1
    GL343885.1(30314-36484)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-110c7.11 si:dkeyp-110c7.1 50.57(n)
    43.97(a)
      797834  NM_001128795.1  NP_001122267.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cact6
    cactus
    16(a)
    1 → many
    2L(16313029-16326101)


    ENSEMBL Gene Tree for NFKBIB (if available)
    TreeFam Gene Tree for NFKBIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFKBIB gene
    NFKBID2  NFKBIA2  NFKBIE2  BCL32  NFKBIZ2  
    1 SIMAP similar gene for NFKBIB using alignment to 5 protein entries:     IKBB_HUMAN (see all proteins):
    RAI14

    NFKBIB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/363 SNPs in NFKBIB are shown (see all 363)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs582497491,2
    C--39394746(+) AAATA-/AATAA 
     ATAAATA
    TTCTT
    3 -- int11Minor allele frequency- AATAAATAAATA:0.00NA 2
    rs178804521,2
    C,F--39395120(+) ACTCT-/CTT   
      T
    /TCTT
    GTTTT
    3 -- int13NS NA 96
    rs664661471,2
    C--39395390(+) GACTCTTGT/-  
            
    TTGTT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs178833921,2
    C,F--39395392(+) TGTTT-/GTTT  
            
    CACGT
    3 -- int13Minor allele frequency- GTTT:0.36NS NA 94
    rs113006701,2
    C--39396772(+) TTTTTT/-TTTTT 3 -- int1 trp32Minor allele frequency- -:0.25NA 4
    rs592865581,2
    C--39397107(+) TTTTT-/TGACAT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs1902403211,2
    --39538033(+) GAGGTA/GGGGGC 1 -- us2k10--------
    rs1925785221,2
    --39538081(+) CTCAAA/GCGATC 1 -- us2k10--------
    rs1466632131,2
    --39538101(+) CAGCCG/TCCCAA 1 -- us2k10--------
    rs31366391,2
    C,F--39538162(+) CTTTCT/ATTTTT 1 -- us2k1 trp38Minor allele frequency- A:0.29NA WA CSA EA 405

    HapMap Linkage Disequilibrium report for NFKBIB (39390340 - 39399534 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NFKBIB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718539CNV Deletion23290073
    esv3793CNV Deletion18987735
    esv2414967CNV Deletion18987734
    esv2718538CNV Deletion23290073
    nsv911676CNV Loss21882294
    nsv911674CNV Loss21882294
    nsv911677CNV Loss21882294
    nsv911675CNV Gain21882294
    nsv820174CNV Gain19587683

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NFKBIB
    DNA2.0 Custom Variant and Variant Library Synthesis for NFKBIB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604495    OMIM disorders: --

    20/24 diseases for NFKBIB (see all 24):    About MalaCards
    shigellosis    toxoplasmosis    human t-cell leukemia virus type 1    thyroiditis
    hiv type 1    measles    leishmaniasis    t-cell leukemia
    endometrial carcinoma    acute lymphoblastic leukemia    lymphoblastic leukemia    influenza
    renal cell carcinoma    atherosclerosis    hepatitis c    obesity
    rheumatoid arthritis    endotheliitis    leukemia    arthritis


    NFKBIB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for NFKBIB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 36 1 16792530 (1)

    Genetic Association Database (GAD): NFKBIB
    Human Genome Epidemiology (HuGE) Navigator: NFKBIB (18 documents)

    Export disorders for NFKBIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFKBIB gene, integrated from 9 sources (see all 120):
    (articles sorted by number of sources associating them with NFKBIB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PubMed id 15024091)1, 2, 9 Chen Y.... Ghosh G. (2004)
    2. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PubMed id 12672800)1, 2, 9 Chen Y.... Ghosh G. (2003)
    3. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 9 Fenwick C....Ghosh S. (2000)
    4. Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. (PubMed id 9763672)1, 3, 9 Okamoto T....Sonta S. (1998)
    5. Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (2008)
    6. Association between anti-tumour necrosis factor treat ment response and genetic variants within the TLR and NF{kappa}B signalling pat hways. (PubMed id 20448286)1, 4 Potter C....Wilson A.G. (2010)
    7. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    8. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    9. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    10. Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia. (PubMed id 20716621)1, 4 Chang J.S....Buffler P.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4793 HGNC: 7798 AceView: NFKBIB Ensembl:ENSG00000104825 euGenes: HUgn4793
    ECgene: NFKBIB Kegg: 4793 H-InvDB: NFKBIB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFKBIB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFKBIB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/nfkbib/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFKBIB gene:
    Search GeneIP for patents involving NFKBIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NFKBIB (IkB-beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NFKBIB   OriGene RNAi products in human, mouse, rat for NFKBIB  
     OriGene qPCR primer pairs and template standards for NFKBIB   OriGene Protein Over-expression Lysate for NFKBIB  
     OriGene MassSpec something-or-other for NFKBIB   OriGene clones in human, mouse for NFKBIB  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFKBIB   OriGene Purified Protein for NFKBIB  
     OriGene ORF clones in mouse, rat for NFKBIB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFKBIB   OriGene Custom Protein Services for NFKBIB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFKBIB
     QIAGEN SeqTarget long-range PCR primers for resequencing NFKBIB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKBIB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFKBIB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFKBIB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFKBIB
     GenScript Custom Purified and Recombinant Proteins Services for NFKBIB GenScript cDNA clones with any tag delivered in your preferred vector for NFKBIB
     GenScript Custom Assay Services for NFKBIB GenScript Custom Superior Antibodies Services for NFKBIB
     GenScript Custom overexpressing Cell Line Services for NFKBIB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NFKBIB  (IkB-beta)

     Regulatory tfbs in NFKBIB promoter
     Search Chromatin IP Primers for NFKBIB
     RT2 qPCR Primer Assay in human, mouse, rat NFKBIB
     Search GNC Networks for NFKBIB
     SABiosciences PCR Arrays including human, mouse, rat NFKBIB
     Search Tocris compounds for NFKBIB (IKBB)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NFKBIB antibodies
     NFKBIB proteins
     NFKBIB lysates
     Antibodies for NFKBIB
     See all of Abcam's Antibodies, Kits and Proteins for NFKBIB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NFKBIB




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NFKBIB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIB
     SwitchGear 3'UTR luciferase reporter plasmids for NFKBIB
     SwitchGear Promoter luciferase reporter plasmids for NFKBIB
     ThermoFisher Antibodies for NFKBIB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NFKBIB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFKBIB
    Customized:
     lentivirus for stable overexpression of NFKBIB
     lentivirus expression plasmids for stable overexpression of NFKBIB
     adenovirus for overexpression of NFKBIB
     LSBio Antibodies in human, mouse, rat for NFKBIB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFKBIB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4