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Aliases for NFKBIB Gene

Aliases for NFKBIB Gene

  • NFKB Inhibitor Beta 2 3 5
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta 2 3
  • Thyroid Receptor-Interacting Protein 9 3 4
  • NF-Kappa-B Inhibitor Beta 2 3
  • TR-Interacting Protein 9 3 4
  • I-Kappa-B-Beta 3 4
  • NF-Kappa-BIB 3 4
  • IkappaBbeta 3 4
  • IkB-Beta 3 4
  • TRIP-9 3 4
  • IkB-B 3 4
  • TRIP9 3 4
  • IKBB 3 4

External Ids for NFKBIB Gene

Previous GeneCards Identifiers for NFKBIB Gene

  • GC19P040002
  • GC19P039781
  • GC19P044066
  • GC19P044082
  • GC19P039390
  • GC19P035837

Summaries for NFKBIB Gene

Entrez Gene Summary for NFKBIB Gene

  • The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for NFKBIB Gene

NFKBIB (NFKB Inhibitor Beta) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and Toll Comparative Pathway. GO annotations related to this gene include signal transducer activity and transcription coactivator activity. An important paralog of this gene is MIR8085.

UniProtKB/Swiss-Prot for NFKBIB Gene

  • Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Gene Wiki entry for NFKBIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKBIB Gene

Genomics for NFKBIB Gene

Regulatory Elements for NFKBIB Gene

Enhancers for NFKBIB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F038673 1.9 FANTOM5 Ensembl ENCODE 6.3 -204.8 -204771 42.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF573 RPS16 ACTN4 RN7SL566P ZNF607 EID2B ENSG00000269688 ENSG00000266963 CAPN12 CATSPERG
GH19F039052 0.9 ENCODE 10.8 +153.8 153836 2.3 MLX ZNF493 ZNF48 ZNF2 ZNF121 ZNF143 SP3 YY2 SP5 REST FBXO27 ENSG00000266963 ENSG00000269069 ENSG00000269172 ENSG00000267375 ENSG00000269792 LOC105372399 ENSG00000269445 ENSG00000269188 LGALS14
GH19F038934 0.7 ENCODE 12.2 +34.8 34761 0.8 SAP130 ARID4B CHD7 ZNF48 ZNF644 ZNF7 TEAD3 ZFHX2 POLR2A PRDM10 FBXO17 SARS2 SIRT2 NFKBIB ENSG00000269486 PIR45188
GH19F039061 0.6 ENCODE 10.8 +161.9 161899 0.0 ZNF280D RBAK ZNF133 EED SCRT2 ETV6 ZEB1 FBXO27 PAK4 NFKBIB SIRT2 GC19M039038 GC19P039085
GH19F038924 1.1 FANTOM5 ENCODE 3.3 +25.3 25252 1.6 CTCF ZMYM3 KLF17 ZNF335 HIC1 GLIS2 ZFHX2 POLR2A PRDM10 EGR2 SARS2 ENSG00000267892 NFKBIB ZFP36 MAP4K1 HNRNPL MRPS12 CCER2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFKBIB on UCSC Golden Path with GeneCards custom track

Promoters for NFKBIB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000346396 343 2401 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263

Genomic Location for NFKBIB Gene

Chromosome:
19
Start:
38,899,657 bp from pter
End:
38,908,894 bp from pter
Size:
9,238 bases
Orientation:
Plus strand

Genomic View for NFKBIB Gene

Genes around NFKBIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFKBIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFKBIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKBIB Gene

Proteins for NFKBIB Gene

  • Protein details for NFKBIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15653-IKBB_HUMAN
    Recommended name:
    NF-kappa-B inhibitor beta
    Protein Accession:
    Q15653
    Secondary Accessions:
    • A8K3F4
    • Q96BJ7

    Protein attributes for NFKBIB Gene

    Size:
    356 amino acids
    Molecular mass:
    37771 Da
    Quaternary structure:
    • Interacts with THRB (via ligand-binding domain) (PubMed:7776974). Interacts with RELA and REL (By similarity). Interacts with COMMD1 (PubMed:16573520). Interacts with inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2 (PubMed:10657303, PubMed:12672800, PubMed:15024091). Interacts with DDRGK1; positively regulates NFKBIB phosphorylation and degradation (PubMed:23675531).

    Alternative splice isoforms for NFKBIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKBIB Gene

Post-translational modifications for NFKBIB Gene

  • Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFKBIB Gene

Domains & Families for NFKBIB Gene

Gene Families for NFKBIB Gene

Protein Domains for NFKBIB Gene

Suggested Antigen Peptide Sequences for NFKBIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15653

UniProtKB/Swiss-Prot:

IKBB_HUMAN :
  • Belongs to the NF-kappa-B inhibitor family.
  • Contains 6 ANK repeats.
Family:
  • Belongs to the NF-kappa-B inhibitor family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with NFKBIB: view

Function for NFKBIB Gene

Molecular function for NFKBIB Gene

GENATLAS Biochemistry:
nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor ar beta,sequestering it in the cytcytoplasm,also inhibiting NF-kappa B DNA binding
UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Gene Ontology (GO) - Molecular Function for NFKBIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 7776974
GO:0004871 signal transducer activity TAS 7776974
GO:0005515 protein binding IPI 10498867
genes like me logo Genes that share ontologies with NFKBIB: view
genes like me logo Genes that share phenotypes with NFKBIB: view

Animal Models for NFKBIB Gene

MGI Knock Outs for NFKBIB:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NFKBIB Gene

Localization for NFKBIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKBIB Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFKBIB gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for NFKBIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NFKBIB: view

Pathways & Interactions for NFKBIB Gene

SuperPathways for NFKBIB Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 TNFR1 Pathway
3 Toll-Like receptor Signaling Pathways
4 4-1BB Pathway
5 Cytosolic sensors of pathogen-associated DNA
genes like me logo Genes that share pathways with NFKBIB: view

Pathways by source for NFKBIB Gene

SIGNOR curated interactions for NFKBIB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NFKBIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 7776974
GO:0007165 signal transduction TAS 7776974
GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with NFKBIB: view

Drugs & Compounds for NFKBIB Gene

(4) Drugs for NFKBIB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NFKBIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFKBIB: view

Transcripts for NFKBIB Gene

Unigene Clusters for NFKBIB Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIB Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NFKBIB Gene

GeneLoc Exon Structure for
NFKBIB
ECgene alternative splicing isoforms for
NFKBIB

Expression for NFKBIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFKBIB Gene

Protein differential expression in normal tissues from HIPED for NFKBIB Gene

This gene is overexpressed in Blymphocyte (15.4), Peripheral blood mononuclear cells (14.4), and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NFKBIB Gene



Protein tissue co-expression partners for NFKBIB Gene

NURSA nuclear receptor signaling pathways regulating expression of NFKBIB Gene:

NFKBIB

SOURCE GeneReport for Unigene cluster for NFKBIB Gene:

Hs.9731

mRNA Expression by UniProt/SwissProt for NFKBIB Gene:

Q15653-IKBB_HUMAN
Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expression patterns with NFKBIB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NFKBIB Gene

Orthologs for NFKBIB Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKBIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKBIB 34 35
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia NFKBIB 34 35
  • 88.01 (n)
cow
(Bos Taurus)
Mammalia NFKBIB 34 35
  • 86.65 (n)
mouse
(Mus musculus)
Mammalia Nfkbib 34 16 35
  • 80.66 (n)
rat
(Rattus norvegicus)
Mammalia Nfkbib 34
  • 80.19 (n)
oppossum
(Monodelphis domestica)
Mammalia NFKBIB 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves NFKBIB 34
  • 63.31 (n)
lizard
(Anolis carolinensis)
Reptilia NFKBIB 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-110c7.1 34
  • 50.64 (n)
NFKBIB 35
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cact 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for NFKBIB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFKBIB Gene

ENSEMBL:
Gene Tree for NFKBIB (if available)
TreeFam:
Gene Tree for NFKBIB (if available)

Paralogs for NFKBIB Gene

Paralogs for NFKBIB Gene

(1) SIMAP similar genes for NFKBIB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NFKBIB: view

Variants for NFKBIB Gene

Sequence variations from dbSNP and Humsavar for NFKBIB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1044284 -- 38,908,555(+) AAAAA(A/G)AAAGA intron-variant, nc-transcript-variant, downstream-variant-500B
rs10713585 -- 38,901,007(+) GGTAG(-/T)TAAGT intron-variant, upstream-variant-2KB
rs11083484 -- 38,902,314(+) atccg(A/C)ccgcc intron-variant
rs11083485 -- 38,902,365(+) gcgcc(C/T)ggcct intron-variant
rs11083487 -- 38,907,057(+) TGAGA(C/T)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFKBIB Gene

Variant ID Type Subtype PubMed ID
esv2414967 CNV deletion 18987734
esv2718538 CNV deletion 23290073
esv2718539 CNV deletion 23290073
esv3793 CNV loss 18987735
nsv1140435 CNV deletion 24896259
nsv1147421 CNV deletion 26484159
nsv1160616 CNV duplication 26073780
nsv820174 CNV gain 19587683

Variation tolerance for NFKBIB Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFKBIB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFKBIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKBIB Gene

Disorders for NFKBIB Gene

Relevant External Links for NFKBIB

Genetic Association Database (GAD)
NFKBIB
Human Genome Epidemiology (HuGE) Navigator
NFKBIB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFKBIB

No disorders were found for NFKBIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFKBIB Gene

Publications for NFKBIB Gene

  1. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 22 46 64
  2. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. (PMID: 15024091) Chen Y. … Ghosh G. (Mol. Cell. Biol. 2004) 3 4 22 64
  3. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes. (PMID: 12672800) Chen Y. … Ghosh G. (J. Biol. Chem. 2003) 3 4 22 64
  4. A subclass of Ras proteins that regulate the degradation of IkappaB. (PMID: 10657303) Fenwick C. … Ghosh S. (Science 2000) 3 4 22 64
  5. Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. (PMID: 9763672) Okamoto T. … Sonta S. (Cytogenet. Cell Genet. 1998) 2 3 22 64

Products for NFKBIB Gene

Sources for NFKBIB Gene

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