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NFKBIA Gene

protein-coding   GIFtS: 74
GCID: GC14M035870

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...


(Previous symbol: NFKBI)
  See NFKBIA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
Inhibitor, Alpha1 2
     MAD-32
NFKBI1 2 3     ikB-alpha2
IKBA2 3 5     NF-Kappa-B Inhibitor Alpha2
Major Histocompatibility Complex Enhancer-Binding Protein MAD32 3     Nuclear Factor Of Kappa Light Chain Gene Enhancer In B-Cells2
I-kappa-B-alpha2 3     IkB-alpha3
IkappaBalpha2 3     MAD33

External Ids:    HGNC: 77971   Entrez Gene: 47922   Ensembl: ENSG000001009067   OMIM: 1640085   UniProtKB: P259633   

Export aliases for NFKBIA gene to outside databases

Previous GC identifers: GC14M033248 GC14M029658 GC14M033860 GC14M034940 GC14M015984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFKBIA Gene:
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The
encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory
responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and
CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with
T-cell immunodeficiency autosomal dominant disease. (provided by RefSeq, Aug 2011)

GeneCards Summary for NFKBIA Gene:
NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is a protein-coding gene. Diseases associated with NFKBIA include ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency, and hypohidrotic ectodermal dysplasia with immune deficiency. GO annotations related to this gene include enzyme binding and identical protein binding. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: IKBA_HUMAN, P25963
Function: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm
through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory
responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to
translocate to the nucleus and activate transcription

Gene Wiki entry for NFKBIA (IκBα) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFKBIA gene promoter:
         AP-1   ATF-2   CUTL1   CREB   deltaCREB   STAT3   Sox9   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NFKBIA promoter sequence
   Search Chromatin IP Primers for NFKBIA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFKBIA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13

NFKBIA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKBIA gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M035870:  view genomic region     (about GC identifiers)

Start:
35,870,716 bp from pter      End:
35,873,960 bp from pter
Size:
3,245 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IKBA_HUMAN, P25963 (See protein sequence)
Recommended Name: NF-kappa-B inhibitor alpha  
Size: 317 amino acids; 35609 Da
Subunit: Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and
NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.
Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts (when
phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the
SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC. Part
of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA.
Interacts with PRMT2. Interacts with PRKACA in platelets; this interaction is disrupted by thrombin and collagen.
Interacts with HIF1AN. Interacts with MEFV
2 PDB 3D structures from and Proteopedia for NFKBIA:
1IKN (3D)        1NFI (3D)    
Secondary accessions: B2R8L6

Explore the universe of human proteins at neXtProt for NFKBIA: NX_P25963

Explore proteomics data for NFKBIA at MOPED

Post-translational modifications: 

  • Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is
    prerequisite to recognition by UBE2D3 leading to polyubiquitination and subsequent degradation1
  • Sumoylated; sumoylation requires the presence of the nuclear import signal1
  • Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in
    cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed
    NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by
    SCF(BTRC) following stimulus-dependent phosphorylation at Ser-32 and Ser-361
  • Deubiquitinated by porcine reproductive and respiratory syndrome virus Nsp2 protein, which thereby interferes with
    NFKBIA degradation and impairs subsequent NF-kappa-B activation1
  • Ubiquitination2 at Lys22
  • Modification sites at PhosphoSitePlus

  • See NFKBIA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065390.1  
    ENSEMBL proteins: 
     ENSP00000216797   ENSP00000450537   ENSP00000451257   ENSP00000450514   ENSP00000451281  
    Reactome Protein details: P25963

    NFKBIA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for NFKBIA
    OriGene Purified Protein for NFKBIA
    OriGene Protein Over-expression Lysate for NFKBIA
    OriGene MassSpec for NFKBIA
    OriGene Custom Protein Services for NFKBIA
    GenScript Custom Purified and Recombinant Proteins Services for NFKBIA
    Novus Biologicals NFKBIA Proteins
    Novus Biologicals NFKBIA Lysate
    Sino Biological Recombinant Protein for NFKBIA
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NFKBIA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NFKBIA 

    NFKBIA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NFKBIA
    R&D Systems Antibodies for NFKBIA (IkB-alpha)
    Cell Signaling Technology (CST) Antibodies for NFKBIA  (IkB-alpha)
    OriGene Antibodies for NFKBIA
    OriGene Custom Antibody Services for NFKBIA
    Novus Biologicals NFKBIA Antibodies
    Abcam antibodies for NFKBIA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NFKBIA
    LSBio Antibodies in human, mouse, rat for NFKBIA

    NFKBIA Assay Products:

    EMD Millipore Kits and Assays for the Analysis of NFKBIA
    OriGene Custom Assay Services for NFKBIA
    R&D Systems ELISAs for NFKBIA (IkB-alpha)
    GenScript Custom Assay Services for NFKBIA
    Cell Signaling Technology (CST) Sandwich ELISA Kits for NFKBIA (IkB-alpha)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for NFKBIA: (see all 3
                        IkBa (Total/Phospho) InstantOne ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P25963

    ProtoNet protein and cluster: P25963

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: IKBA_HUMAN, P25963
    Similarity: Belongs to the NF-kappa-B inhibitor family
    Similarity: Contains 5 ANK repeats


    Find genes that share domains with NFKBIA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKBA_HUMAN, P25963
    Function: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm
    through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory
    responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to
    translocate to the nucleus and activate transcription
    Induction: Induced in adherent monocytes

         Genatlas biochemistry entry for NFKBIA:
    nuclear transcription factor of kappa light chain gene enhancer in B cells (NF-kappa B) inhibitor
    alpha,secontinuously shutting between nucleus and cytoplasm,sequestering NKKB in the cytoplasm,inhibiting NFKB
    activation after modification by UBL1,inactivated in Hodgkin and Reed-Sternberg cells,ubiquinylated by a new
    factor termed NFKBIAE3-F1 for signal dependent activation of NF kappa B

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10498867
    GO:0008134transcription factor binding TAS10928981
    GO:0008139nuclear localization sequence binding IPI1493333
    GO:0019899enzyme binding IPI16648481
    GO:0031072heat shock protein binding IEA--
         
    Find genes that share ontologies with NFKBIA           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NFKBIA:
     Decreased nuclei size in G2M  Decreased number of cells in m  Upregulation of NF-kappaB path 

         8 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Nfkbia):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  normal 

    Find genes that share phenotypes with NFKBIA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NFKBIA: Nfkbiatm1Stw Nfkbiatm1Fey Nfkbiatm1.1Kbp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFKBIA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFKBIA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFKBIA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFKBIA

    miRNA
    Products:
        
    miRTarBase miRNAs that target NFKBIA:
    hsa-let-7b-5p (MIRT052129), hsa-mir-24-3p (MIRT030500), kshv-mir-k12-1-5p (MIRT003202), hsa-mir-335-5p (MIRT017719), hsa-mir-30e-3p (MIRT006695)

    Block miRNA regulation of human, mouse, rat NFKBIA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFKBIA (see all 9):
    hsa-miR-300 hsa-miR-548e hsa-miR-381 hsa-let-7a-2* hsa-miR-624* hsa-miR-548a-3p hsa-miR-493* hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFKBIA
    Predesigned siRNA for gene silencing in human, mouse, rat NFKBIA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFKBIA

    Clone
    Products:
         
    OriGene clones in human, mouse for NFKBIA (see all 7)
    OriGene ORF clones in mouse, rat for NFKBIA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFKBIA (NM_020529)
    Sino Biological Human cDNA Clone for NFKBIA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKBIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIA
    Addgene plasmids for NFKBIA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFKBIA
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFKBIA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKBA_HUMAN, P25963: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear
    localization signal (NLS) and a CRM1-dependent nuclear export (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4
    extracellular2
    mitochondrion2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16648481
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--
    GO:0033256I-kappaB/NF-kappaB complex TAS16938301

    Find genes that share ontologies with NFKBIA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NFKBIA About   (see all 113)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    TRAIL Pathway0.40
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    3RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    4Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    5B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36


    Find genes that share SuperPaths with NFKBIA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for NFKBIA (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NFKBIA (see all 65)
        Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    NF-kappaB Activation by Viruses
    ITK and TCR Signaling
    RANK Pathway

    1 Cell Signaling Technology (CST) Pathway for NFKBIA
        NF-kappaB Signaling

    2 Tocris Bioscience Pathways for NFKBIA
        Toll-like Receptor Pathway
    NF-kappaB Pathway

    Selected GeneGo (Thomson Reuters) Pathways for NFKBIA (see all 50)
        Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for NFKBIA (see all 30)
        Apoptosis
    NOD pathway
    Apoptosis Modulation and Signaling
    AGE/RAGE pathway
    Oncostatin M Signaling Pathway

    3 Sino Biological Pathways for NFKBIA
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    Selected Reactome Pathways for NFKBIA (see all 7)
        NF-kB is activated and signals survival
    Downstream TCR signaling
    FCERI mediated NF-kB activation
    RIP-mediated NFkB activation via ZBP1
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    Selected Kegg Pathways  (Kegg details for NFKBIA) (see all 31):
        Chemokine signaling pathway
    NF-kappa B signaling pathway
    Apoptosis
    Osteoclast differentiation
    Toll-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFKBIA (see all 15): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFKBIA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFKBIA (P259631, 2, 3 ENSP000002167974) via UniProtKB, MINT, STRING, and/or I2D (see all 256)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198381, 2, 3, ENSP000002265744EBI-307386,EBI-300010 MINT-48656 MINT-47903 MINT-47885 MINT-48541 I2D: score=8 STRING: ENSP00000226574
    RELAQ042061, 2, 3, ENSP000003842734EBI-307386,EBI-73886 MINT-48917 MINT-47847 I2D: score=11 STRING: ENSP00000384273
    CHUKO151111, 2, 3, ENSP000003594244EBI-307386,EBI-81249 MINT-47841 I2D: score=8 STRING: ENSP00000359424
    IKBKBO149201, 2, 3, ENSP000003391514EBI-307386,EBI-81266 MINT-47842 I2D: score=8 STRING: ENSP00000339151
    IKBKGQ9Y6K91, 2, 3, ENSP000003586224EBI-307386,EBI-81279 MINT-47843 I2D: score=7 STRING: ENSP00000358622
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006915apoptotic process TAS10747850

    Find genes that share ontologies with NFKBIA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFKBIA (IKBA)

    Selected Novoseek inferred chemical compound relationships for NFKBIA gene (see all 137)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pdtc 82.1 17 11006087 (2), 16772089 (1), 19662350 (1), 19722233 (1) (see all 14)
    tpck 75.4 14 15791843 (3), 12411051 (2), 10381628 (1), 12198114 (1)
    mg 132 65 11 10930537 (1), 11301346 (1), 11464292 (1), 15845394 (1) (see all 9)
    ly294002 62.6 13 12086898 (2), 11689575 (1), 18771813 (1), 11796489 (1) (see all 9)
    sb 203580 60.5 10 10428782 (2), 11120850 (1), 16772089 (1), 16806824 (1) (see all 8)
    parthenolide 60.1 7 16778086 (1), 18846331 (1), 15256485 (1), 10704251 (1) (see all 5)
    curcumin 59 26 16081677 (2), 12393461 (2), 16299251 (1), 16519151 (1) (see all 17)
    n-tosyl-l-phenylalanine chloromethyl ketone 58 6 16288038 (1), 10722693 (1), 12198114 (1), 15280021 (1)
    pd 98,059 53 7 11322796 (3), 15893541 (1), 18996613 (1), 19288477 (1)
    acetyl-11-keto-beta-boswellic acid 50.8 1 15611276 (1)



    Find genes that share compounds with NFKBIA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NFKBIA gene: 
    NM_020529.2  

    Unigene Cluster for NFKBIA:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
    Hs.81328  [show with all ESTs]
    Unigene Representative Sequence: BM908726
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216797(uc001wtf.4) ENST00000554001 ENST00000557140 ENST00000557389
    ENST00000555371 ENST00000557100 ENST00000556664 ENST00000557459 ENST00000555629
    ENST00000553342
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFKBIA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFKBIA (see all 9):
    hsa-miR-300 hsa-miR-548e hsa-miR-381 hsa-let-7a-2* hsa-miR-624* hsa-miR-548a-3p hsa-miR-493* hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidNFKBIA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NFKBIA
    Predesigned siRNA for gene silencing in human, mouse, rat NFKBIA
    Clone
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    OriGene clones in human, mouse for NFKBIA (see all 7)
    OriGene ORF clones in mouse, rat for NFKBIA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFKBIA (NM_020529)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKBIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKBIA
    Addgene plasmids for NFKBIA 
    Primer
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    OriGene qPCR primer pairs and template standards for NFKBIA
    OriGene qSTAR qPCR primer pairs in human, mouse for NFKBIA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFKBIA
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    Additional mRNA sequence: 

    AK311515.1 AK313421.1 AY033600.1 BC002601.2 BC004983.1 BT007091.1 M69043.1 

    Selected DOTS entries (see all 31):

    DT.456318  DT.100879311  DT.100879299  DT.100879303  DT.97858073  DT.100700347  DT.95348555  DT.100044299 
    DT.120746013  DT.100879292  DT.100879313  DT.120746036  DT.120746044  DT.100879297  DT.120746032  DT.120746042 
    DT.120746050  DT.100879308  DT.100879312  DT.92449292  DT.100044722  DT.100879294  DT.120746001  DT.100687712 

    Selected AceView cDNA sequences (see all 544):

    BM760843 BM794540 BC004983 AA504376 W60659 BQ215714 AI168375 AI937453 
    BM699797 BP381941 AA047565 CR623392 BM847573 BQ130059 AI288741 CD370833 
    AW304347 BU615707 CB151780 BX094258 BI761162 BE857519 AA306661 CR603242 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFKBIA (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:        -           -           -                                                               
    SP2:        -           -           -                       -                                       
    SP3:                    -           -                                                               
    SP4:        -           -           -                                                               
    SP5:        -           -           -     -     -     -                                             


    ECgene alternative splicing isoforms for NFKBIA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NFKBIA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACAGCCAG
    NFKBIA Expression
    About this image


    NFKBIA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Thymus (Hematopoietic System)
             Thymus
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    NFKBIA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFKBIA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.81328
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFKBIA (see all 15): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKBIA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for NFKBIA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfkbia1 , 5 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha less1, 5 89.7(n)1
    92.04(a)1
      12 (24.00 cM)5
    180351  NM_010907.21  NP_035037.21 
     554894115 
    chicken
    (Gallus gallus)
    Aves NFKBIA1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha less 74.27(n)
    74.92(a)
      396093  NM_001001472.2  NP_001001472.2 
    lizard
    (Anolis carolinensis)
    Reptilia NFKBIA6
    nuclear factor of kappa light polypeptide gene enh...
    72(a)
    1 ↔ 1
    2(54401943-54406467)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242692 Xenopus laevis transcribed sequence with weak similarity to protein refNP_065390.1 (H.sapiens) nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Nuclear factor of kappa light chain gene enhancer in B-cells [Homo sapie less 76.37(n)    BX844178.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb81f082 wufb81f08 77.7(n)   323099  BC062524.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cact1 , 3 antifungal humoral response (sensu
    Invertebrata) transcription factor,
    cytoplasmic sequestering less3
    cactus1
    37(a)3
    50.74(n)1
    41.07(a)1
      349691  NM_001273567.11  NP_001260496.11 


    ENSEMBL Gene Tree for NFKBIA (if available)
    TreeFam Gene Tree for NFKBIA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFKBIA gene
    NFKBID2  NFKBIB2  NFKBIE2  BCL32  NFKBIZ2  
    4 SIMAP similar genes for NFKBIA using alignment to 5 protein entries:     IKBA_HUMAN (see all proteins):
    IkBa    NFKBIE    NFKB1    ANKDD1A

    Find genes that share paralogs with NFKBIA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NFKBIA (see all 213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289331001,2,,4
    CEctodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID)4 pathogenic116871451(-) CGACAG/TCGGCC 2 S I mis1 ese30--------
    rs711212891,2
    C--15985167(+) AAGAG-/GTAAGCTATTAAAAAAAG
    G
    /TAAGCTATTAAAAAAAGGG
    GGGGG
    1 -- int11NA 2
    rs1830409621,2
    --16867923(+) TTTCAC/TAACAG 1 -- int10--------
    rs1883744041,2
    --16867996(+) AGTCCC/TATTTC 1 -- int10--------
    rs1415333311,2
    C--16868040(+) TGAGAA/TCTTTC 1 -- int10--------
    rs1501051221,2
    --16868130(+) ATCAAC/TGGGAT 1 -- int10--------
    rs1162698381,2
    F--16868131(+) TCAACG/AGGATG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs31380551,2
    C,F,A,H--16868149(-) TCTCCA/GTTGTC 1 -- int135Minor allele frequency- G:0.33NA NS EA WA CSA 4073
    rs1929988481,2
    --16868350(+) TCTGCC/TGGAGG 1 -- int10--------
    rs1167650511,2
    F--16868481(+) ATTATG/ATACAC 1 -- ut311Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for NFKBIA (35870716 - 35873960 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NFKBIA:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1872n71CNV Loss21882294
    nsv901618CNV Loss21882294
    nsv901616CNV Loss21882294

    Human Gene Mutation Database (HGMD): NFKBIA
    Locus Specific Mutation Databases (LSDB): NFKBIA

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing NFKBIA:
    Glioma
    SeqTarget long-range PCR primers for resequencing NFKBIA
    DNA2.0 Custom Variant and Variant Library Synthesis for NFKBIA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 164008   
    OMIM disorders: 612132  
    UniProtKB/Swiss-Prot: IKBA_HUMAN, P25963
  • Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID) [MIM:612132]:
    A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more
    ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of
    pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 6 diseases for NFKBIA:    
    About MalaCards
    ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency    hypohidrotic ectodermal dysplasia with immune deficiency    autosomal dominant disease    ectodermal dysplasia
    giant cell glioblastoma    gliosarcoma

    4 diseases from the University of Copenhagen DISEASES database for NFKBIA:
    Cancer     Arthritis     Atherosclerosis     Inflammatory bowel disease

    Find genes that share disorders with NFKBIA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NFKBIA gene (see all 82)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 77.2 107 10567330 (2), 17409387 (2), 20403612 (2), 10722693 (2) (see all 83)
    tumors 65.9 122 10567330 (2), 17409387 (2), 20403612 (2), 10722693 (2) (see all 93)
    inflammation 65.4 11 10364447 (2), 10964761 (1), 19542021 (1), 17108131 (1) (see all 9)
    leukemia t-cell 51.8 3 8676482 (1), 9632633 (1), 10336413 (1)
    ectodermal dysplasia 42.1 8 17931563 (2), 18794870 (1), 11224521 (1), 20080849 (1)
    cancer 40.5 25 15671248 (4), 11520600 (2), 19857958 (2), 15256061 (2) (see all 15)
    rheumatoid arthritis 35.5 2 10072544 (1), 17701919 (1)
    lymphocytic leukemia chronic b-cell 30 1 17568818 (1)
    myeloma 29 7 12377412 (1), 15781640 (1), 17701919 (1), 11740821 (1) (see all 7)
    hnscc 26.5 5 17785205 (1), 16953224 (1), 18448428 (1)

    Genetic Association Database (GAD): NFKBIA
    Human Genome Epidemiology (HuGE) Navigator: NFKBIA (68 documents)

    Export disorders for NFKBIA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NFKBIA gene, integrated from 10 sources (see all 1252):
    (articles sorted by number of sources associating them with NFKBIA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. (PubMed id 14523047)1, 2, 4, 9 Courtois G.... Casanova J.L. (J. Clin. Invest. 2003)
    2. Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. (PubMed id 1829648)1, 2, 3 Haskill S.... Baldwin A.S. Jr. (Cell 1991)
    3. Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. (PubMed id 12377412)1, 4, 9 Parker K.M....Berenson J.R. (Cancer Genet. Cytogenet. 2002)
    4. A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)1, 2, 9 Fenwick C....Ghosh S. (Science 2000)
    5. Variant in the 3' region of the IkappaBalpha gene associated with insulin resistance in Hispanic Americans: The IRAS Family Study. (PubMed id 19798070)1, 4, 9 Miller M.R....Fingerlin T.E. (Obesity (Silver Spring) 2010)
    6. IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. (PubMed id 19797428)1, 4, 9 He Y....Cao G. (Carcinogenesis 2009)
    7. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    8. IkappaB genetic polymorphisms and invasive pneumococcal disease. (PubMed id 17463416)1, 4, 9 Chapman S.J....Hill A.V. (Am. J. Respir. Crit. Care Med. 2007)
    9. Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations. (PubMed id 17354114)1, 4, 9 Gao J....Sun X.F. (Scand. J. Gastroenterol. 2007)
    10. HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients. (PubMed id 17318773)1, 4, 9 Katarina K....Marie C. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4792 HGNC: 7797 AceView: NFKBIA Ensembl:ENSG00000100906 euGenes: HUgn4792
    ECgene: NFKBIA Kegg: 4792 H-InvDB: NFKBIA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NFKBIA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFKBIA Genetics and Cytogenetics in Oncology and Haematology
    NFKBIAbasehttp://bioinf.uta.fi/NFKBIAbase/
    SeattleSNPshttp://pga.gs.washington.edu/data/nfkbia/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFKBIA gene:
    Search GeneIP for patents involving NFKBIA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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