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NFKB2 Gene

protein-coding   GIFtS: 74

GC10P104144
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for NFKB2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
H2TF1 3
LYT-10 1, 2
LYT10 2, 3, 5
Lyt10 3
OTTHUMP00000020371 2
OTTHUMP00000059136 2
Descriptions
DNA-binding factor KBF2 3
Lymphocyte translocation chromosome 10 3
Oncogene Lyt-10 3
nuclear factor of kappa light chain gene enhancer in
B-cells 2 2
nuclear factor of kappa light polypeptide gene enhancer in
B-cells 2 2
nuclear factor of kappa light polypeptide gene enhancer in
B-cells 2 (p49/p100) 2
External Ids
HGNC: 77951
Entrez Gene: 47912
UniProtKB: Q006533
Ensembl: ENSG000000771507
Search outside databases for aliases for NFKB2 gene

Previous GC identifers: GC10P103047 GC10P103387 GC10P104285 GC10P103818

Summaries
for NFKB2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for NFKB2:
NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors,
cell adhesion molecules, and some acute phase proteins in health and in various disease states.
NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled
particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of
NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma,
septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete
and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate
immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) [PubMed
9895331] and Baldwin (1996) [PubMed 8717528].[supplied by OMIM]

UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653
Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
types and is involved in many biological processed such as inflammation, immunity,
differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the
individual dimers have distinct preferences for different kappa-B sites that they can bind with
distinguishable affinity and specificity. Different dimer combinations act as transcriptional
activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of
post-translational modification and subcellular compartmentalization as well as by interactions
with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an
inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a
conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in
response to different activators, subsequently degraded thus liberating the active NF-kappa-B
complex which translocates to the nucleus. In a non-canonical activation pathway, the
MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its
proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The
NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52
homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic
retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational
processing. The proteasome-mediated process ensures the production of both p52 and p100 and
preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3',
located in the enhancer region of genes involved in immune response and acute phase reactions. p52
and p100 are respectively the minor and major form; the processing of p100 being relatively poor.
Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in
synergy with p65

Gene Wiki entry for NFKB2

Genomic Location
for NFKB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NFKB2 gene  

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24

NFKB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104144:     (about GC identifiers)

Start:
 104,144,219 bp from pter
End:
 104,152,271 bp from pter
Size:
 8,053 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  

Proteins
for NFKB2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653 (See protein sequence)
Recommended Name: Nuclear factor NF-kappa-B p100 subunit  
Size: 900 amino acids; 96749 Da
Subunit: Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B
p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B
p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the
NF-kappa-B p50-p50 homodimer and BCL3
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an
inactive form complexed to an inhibitor (I-kappa-B)
Sequence caution: Sequence=CAA43715.1; Type=Frameshift; Positions=455, 470, 899;
PDB structure from and Proteopedia :
1A3Q (3D)    2D96 (3D)    
Secondary accessions: Q04860 Q9BU75 Q9H471 Q9H472
Alternative splicing: 2 isoforms:  Q00653-1   Q00653-2   

Post-translational modifications:

  • While translation occurs, the particular unfolded structure after the GRR repeat promotes the
    generation of p52 making it an acceptable substrate for the proteasome. This process is known as
    cotranslational processing. The processed form is active and the unprocessed form acts as an
    inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in
    the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing1
  • Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then
    triggering its proteasome-dependent processing1
  • Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named
    PID, which contains the death domain1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001070961.1  NP_001070962.1  NP_002493.3  


    ENSEMBL proteins: 
    ENSP00000337001 ENSP00000358983 ENSP00000189444 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant NFKB2 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (NFkB p100 / p52)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA15677444
    GO:0005654 nucleoplasm EXP10723127
    GO:0005737 cytoplasm IDA15677444
    GO:0005829 cytosol EXP10723127
    GO:0033257 Bcl3/NF-kappaB2 complex IDA9407099
    About this table

    Antibodies for NFKB2: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of NFKB2
    Sigma-Aldrich Antibodies for NFKB2
    R&D Systems Antibodies for NFKB2
    Cell Signaling Technology (CST) Antibodies for NFKB2  (nf-kappa-b2)
    Antibodies from Abcam (NFkB p100 / p52), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (NFKB2)
    Novus Biologicals Antibodies for NFKB2

    Assays for NFKB2: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of NFKB2
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for NFKB2

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro domains/families (see all 8 ):
     IPR011029 DEATH-like
     IPR002909 IPT_TIG_rcpt
     IPR000488 Death
     IPR000451 NF_Rel_dor
     IPR013783 Ig-like_fold


       GeneDecks  NFKB2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q00653

    ProtoNet protein and cluster: Q00653

    5 Blocks protein families:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB000488 Death domain
    IPB002110 Ankyrin repeat signature
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653
    Domain: The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of
    DNA-binding by p52 homodimers, and/or transcription activation (By similarity)
    Domain: The glycine-rich region (GRR) appears to be a critical element in the generation of p52
    Similarity: Contains 7 ANK repeats
    Similarity: Contains 1 death domain
    Similarity: Contains 1 RHD (Rel-like) domain

    Gene Function
    for NFKB2

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (NFKB2)
    Millipore RNAi Products for the Analysis of NFKB2 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (NFKB2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001077493

                  Applied Biosystems Silencer® siRNAs for NFKB2

                  Sigma-Aldrich siRNA for NFKB2  
                         Sigma-Aldrich shRNA Panels and shRNA for NFKB2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001077493
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001077493
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001077493 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001077494

    UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653
    Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
    types and is involved in many biological processed such as inflammation, immunity,
    differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
    complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
    REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the
    individual dimers have distinct preferences for different kappa-B sites that they can bind with
    distinguishable affinity and specificity. Different dimer combinations act as transcriptional
    activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of
    post-translational modification and subcellular compartmentalization as well as by interactions
    with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an
    inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a
    conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in
    response to different activators, subsequently degraded thus liberating the active NF-kappa-B
    complex which translocates to the nucleus. In a non-canonical activation pathway, the
    MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its
    proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The
    NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52
    homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic
    retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational
    processing. The proteasome-mediated process ensures the production of both p52 and p100 and
    preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3',
    located in the enhancer region of genes involved in immune response and acute phase reactions. p52
    and p100 are respectively the minor and major form; the processing of p100 being relatively poor.
    Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in
    synergy with p65

    Genatlas biochemistry entry for NFKB2:
    nuclear transcription factor of kappa light chain gene enhancer in B cells,2,(encoding the p100
    precursor and the amino-terminal active p52(p49)subunit),NF-kappa B/REL family

    4 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Nfkb2):

    hematopoietic systemhomeostasis/metabolismimmune systemrenal/urinary system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity TAS1760839 1876189
    GO:0003713 transcription coactivator activity TAS1876189
    GO:0005515 protein binding IPI11526476 16108830
    About this table

    Pathways & Interactions
    for NFKB2

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/37 Invitrogen iPath™ Online BioAtlas - Pathways for NFKB2 (see all 37 ) (Maps provided by GeneGo):
     IL4 signaling pathway
     A2BR signaling via G-alpha-q: PRKCB/G/Q specific pathways (map 3a)
     Putative SUMO-1 pathway
     PDGF signaling via STATs and NF-kB
     TCR and CD28 co-stimulation in activation of NF-kB

       GeneDecks  NFKB2 for the pathways selected above  
    About GeneDecksing

    5/40 Millipore Pathways for NFKB2 (see all 40 )
     Immune response MIF-mediated glucocorticoid regulation
     Development TGF-beta receptor signaling
     Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
     Transcription NF-kB signaling pathway
     Transcription P53 signaling pathway

       GeneDecks  NFKB2 for the pathways selected above  
    About GeneDecksing

    5/61 Sigma-Aldrich "Your Favorite Gene" Pathways for  NFKB2  (Your Favorite Gene powered by Ingenuity) (see all 61 ) 
     Androgen Signaling
     Role of RIG1-like Receptors in Antiviral Innate Immunity
     PTEN Signaling
     CD27 Signaling in Lymphocytes
     IL-10 Signaling

       GeneDecks  NFKB2 for the pathways selected above  
    About GeneDecksing

    1 Cell Signaling Technology (CST) Pathway for NFKB2: 
     NF-kB Signaling

       GeneDecks  NFKB2 for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for NFKB2):
     hsa04010 MAPK signaling pathway
     hsa05200 Pathways in cancer

       GeneDecks  NFKB2 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  NFKB2 


    5/294 Interacting proteins for NFKB2 (Q006531, 2 ENSP000003370013) via UniProtKB, MINT, and/or STRING (see all 294 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, ENSP000002265743MINT-48553 MINT-6178467 MINT-6178504 MINT-47910 MINT-48724 MINT-6178544 MINT-48674 MINT-48585 MINT-47890 MINT-6178520 MINT-47923 MINT-6178488 STRING (score=.964)
    RELBQ012012, ENSP000002214523MINT-49015 MINT-6178544 MINT-48631 MINT-48776 MINT-6178520 MINT-48018 MINT-47926 MINT-6178488 STRING (score=.996)
    RELAQ042062, ENSP000003115083MINT-6178467 MINT-47896 MINT-48764 MINT-47925 MINT-48623 MINT-48943 MINT-6178544 MINT-6178520 STRING (score=.99)
    RELQ048642, ENSP000002950253MINT-48598 MINT-6178520 MINT-47915 MINT-48733 MINT-6178504 MINT-47893 MINT-6178544 STRING (score=.964)
    BCL3P207492, ENSP000001642273MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544 STRING (score=.999)
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002268 follicular dendritic cell differentiation IEA--
    GO:0002467 germinal center formation IEA--
    GO:0006355 regulation of transcription, DNA-dependent IDA8360178
    GO:0007165 signal transduction IEA--
    GO:0030198 extracellular matrix organization IEA--
    About this table

    Drugs & Compounds
    for NFKB2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for NFKB2
    Sigma-Aldrich Small Molecules for NFKB2:
    Blocker Inhibitor

    Compounds for NFKB2 available from Tocris Bioscience
    CompoundAction CAS number
    Bay 11-7821Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation[19542-67-7]
    LuteolinAnti-inflammatory, antioxidant and free radical scavenger[491-70-3]
    Caffeic acid phenethyl esterSpecific inhibitor of NF-kappaB activation[104594-70-9]
    Bay 11-7085Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation[196309-76-9]
    About this table



    Transcripts
    for NFKB2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (NFKB2)
    Millipore RNAi Products for the Analysis of NFKB2 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (NFKB2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001077493

                  Sigma-Aldrich siRNA for NFKB2  
                         Sigma-Aldrich shRNA Panels and shRNA for NFKB2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001077493  NM_001077494  NM_002502  

    REFSEQ mRNAs for NFKB2 gene (3 alternative transcripts): 

    NM_001077493.1   NM_001077494.1   NM_002502.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001077493  NM_001077494  NM_002502  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001077493
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001077493
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001077493 

    Additional cDNA sequence: 

    AK098415.1 AK292654.1 BC002844.2 BT009769.1 S76638.1 U09609.2 X61498.1 X61499.1 

    11 DOTS entries:

    DT.91745508  DT.100787875  DT.100787878  DT.456108  DT.102827323  DT.121252623  DT.100787874  DT.121252632 
    DT.121252646  DT.75102361  DT.91745515 

    24/151 AceView cDNA sequences (see all 151 ):

    BX400217 BI258254 BM763392 BE891295 CA432410 BF876907 BQ448336 BM452045 
    BM763876 CA414621 AW015196 BM548928 AI076209 BQ961701 BG764149 BG119731 
    BQ654191 BU189580 BQ646520 BM833519 AI912172 BU737985 BI769417 BE410261 

    highest scoring ESTs for NFKB2:

    S76638 X61498 AA255553 AA256597 AA693553 AA952897 AI191174 AI218161 AI498878 AI738890 

    Unigene Cluster for NFKB2:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
    Hs.73090  [show with all ESTs]
    Unigene Representative Sequence: NM_001077494


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NFKB2 (see all 12 )

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
    SP1:                                                                                            -                                         -                     
    SP2:                                                                                                                                      -                     
    SP3:                                                                                            -                                                               
    SP4:                                                                                                                                                            
    SP5:                    -     -                                                                                                                                 

    ExUns: 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
    SP1:        -                       -                                                   
    SP2:        -                       -                                                   
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for NFKB2

    3 Ensembl transcripts including schematic representations:
    ENST00000336486  ENST00000369966  ENST00000189444  

    Expression
    for NFKB2

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NFKB2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NFKB2

    1 / 2 / 3

    8 probe-sets matching NFKB2 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    544_at2, 3 U95-A 1 1.00 1.00 0.93 1.26 S76638 1.00 1.00 1.00 1

    		535_s_at2, 3 U95-A 1 1.00 1.00 0.68 0.52 U20816 0.20 1.00 0.72 1
    40362_at2, 3 U95-A 1 1.00 1.00 0.98 1.18 X61498 1.00 1.00 1.00 1
    545_g_at2, 3 U95-A 1 1.00 1.00 0.97 1.07 S76638 1.00 1.00 1.00 1

    		209636_at2, 3 U133-A 1 1.00 1.00 -- -- BC002844 0.80 1.00 0.91 1

    		207535_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002502 0.60 1.00 0.82 1

    		209636_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		207535_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  NFKB2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGAAGGGGAG

    SOURCE GeneReport for Unigene cluster: Hs.73090

    Expression variation in blood from EXPOLDB for NFKB2

    Orthologs
    for NFKB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for NFKB2 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 NFKB21   -- nuclear factor of kappa light polypeptide gene enhancer more 89.98(n)
    92.76(a)    		 486858  XM_543988.2  XP_543988.2 
    cow
    (Bos taurus)    		 NFKB21   -- nuclear factor of kappa light polypeptide gene enhancer more 89.48(n)
    92.11(a)    		 526392  XM_604762.3  XP_604762.3 
    rat
    (Rattus norvegicus)    		 Nfkb21   -- nuclear factor of kappa light polypeptide gene enhancer more 86.82(n)
    91.09(a)    		 309452  NM_001008349.1  NP_001008350.1 
    mouse
    (Mus musculus)    		 Nfkb21, 5 19 (45.75 cM)5
    		 nuclear factor of kappa light polypeptide gene enhancer more1, 5 86.5(n)1
    91.88(a)1    		 180341  NM_019408.21  NP_062281.11 
     AF1351255  AF1553725  (see all 29)
    zebrafish
    (Danio rerio)    		 wufa03b022   -- wufa03b02 73.28(n) 334761  BM102747.1 
    About this table        Species with no ortholog for NFKB2

    ENSEMBL Gene Tree for NFKB2

    Paralogs
    for NFKB2

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for NFKB2 gene
    NFKB12  REL2  RELB2  RELA2  

    SNPs/Variants
    for NFKB2

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/84 NCBI SNPs in NFKB2 are shown (see all 84 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 30)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs15725321,2
    		C,F,H104144673(-) TGTACA/GGACAC 3 -- int1 ng516Minor allele frequency- G:0.01EU EA WA NA NS 608
    rs70830381,2
    		C,F,H104142775(+) GATAGC/TTTATG 2 -- ng518Minor allele frequency- T:0.01EU EA WA 838
    --
    rs38339041,2
    		C,F104144317(+) GCGCGG/-AGAGA 3 -- ng51 ut511Minor allele frequency- -:0.27NS 152
    --
    rs362269541,2
    		C,F104145335(+) TAGACT/CGTCGA 3 -- ng51 int11Minor allele frequency- C:0.03NS 160
    rs127693161,2
    		F104142741(+) AAAACG/ATCTGG 2 -- ng514Minor allele frequency- A:0.13NA EA 362
    --
    rs115748421,2
    		F104144058(+) CCGGCC/TGAACT 3 -- ng511Minor allele frequency- T:0.05NA 40
    --
    rs127651351,2
    		C104142423(+) AAActC/Tagggg 2 -- ng510--------
    --
    rs73582281,2
    		C104144848(+) TTAGGG/TGGGGG 3 -- ng51 int10--------
    --
    rs115748431,2
    		F104144266(+) CCTGAG/ACCCTG 3 -- ng51 ut511Minor allele frequency- A:0.07NA 40
    --
    rs115748481,2
    		F104149092(+) CGGCGC/GGGGCC 3 A/G mis1 ese31Minor allele frequency- G:0.07NA 40
    About this table

    HapMap Linkage Disequilibrium images for NFKB2 (up to first 250kb)

    Disorders & Mutations
    for NFKB2

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 164012

    UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653
  • A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma
    (B-NHL). Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C
    alpha variant
  • A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL)
    cell line. This rearrangement produces the p80HT gene which encodes for a truncated 80 kDa protein
    (p80HT)
  • In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous
    chromosomal aberrations, such as internal deletions

    • 8 Novoseek disease relationships for NFKB2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoid neoplasm 70.47 3 9150386 (1), 7651435 (1), 9523851 (1)
    lymphoma t-cell 58.54 1 7597296 (1)
    lymphoma b-cell 39.77 1 7949142 (1)
    lymphoma 39.26 6 9150386 (1), 10713675 (1), 9021684 (1), 7597296 (1)
    myeloma 26.93 1 17692804 (1)
    chromosomal aberrations 15.40 1 8108136 (1)
    tumors 3.00 6 7949142 (2), 8378093 (1), 1760839 (1)
    cancer 0.00 1 1760839 (1)
    About this table

    Genatlas disease: NFKB2
    lymphoma,B cell,non Hodgkin,associated with breakpoint in t(10;14)(q24;q32) translocation

    Genetic Association Database: NFKB2
    Human Genome Epidemiology Navigator: NFKB2 (5 documents)
    Tumor Gene Database: NFKB2

    Medical News
    for NFKB2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for NFKB2

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		14/171 PubMed articles for NFKB2 gene (see all 171 ):

    Search for NFKB2

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Search String
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NFKB2

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 4791 HGNC: 7795 AceView: NFKB2 Ensembl:ENSG00000077150 euGenes: HUgn4791
    ECgene: NFKB2 H-InvDB: NFKB2

    Other Databases showing NFKB2

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing NFKB2

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for NFKB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nfkb2/

    Licensable Technologies
    for NFKB2

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for NFKB2

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NFKB2:
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    		  Free SNP selection tool



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     Tocris compounds for NFKB2




     Drugs for NFKB2
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