Aliases for NFKB2 Gene
Aliases for NFKB2 Gene
- Nuclear Factor Kappa B Subunit 2 2 3 5
- Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2 (P49/P100) 2 3
- Lymphocyte Translocation Chromosome 10 Protein 3 4
- DNA-Binding Factor KBF2 3 4
- Oncogene Lyt-10 3 4
- H2TF1 3 4
- LYT10 3 4
- Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2 4
- Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells 2 3
- Nuclear Factor NF-Kappa-B P100 Subunit 3
- Nuclear Factor NF-Kappa-B P52 Subunit 3
External Ids for NFKB2 Gene
- HGNC: 7795
- Entrez Gene: 4791
- Ensembl: ENSG00000077150
- OMIM: 164012
- UniProtKB: Q00653
Previous GeneCards Identifiers for NFKB2 Gene
- GC10P103047
- GC10P103387
- GC10P104285
- GC10P103818
- GC10P104144
- GC10P097787
Summaries for NFKB2 Gene
-
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
GeneCards Summary for NFKB2 Gene
NFKB2 (Nuclear Factor Kappa B Subunit 2) is a Protein Coding gene. Diseases associated with NFKB2 include Immunodeficiency, Common Variable, 10 and Immunodeficiency, Common Variable, 1. Among its related pathways are RANK Signaling in Osteoclasts and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is NFKB1.
UniProtKB/Swiss-Prot for NFKB2 Gene
-
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5-GGRNNYYCC-3, located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
-
NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections.
Additional gene information for NFKB2 Gene
- Monarch Initiative
- Search for NFKB2 at DataMed
- Search for NFKB2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKB2 Gene
Genomics for NFKB2 Gene
GeneHancer (GH) Regulatory Elements for NFKB2 Gene
Regulatory Element Products
Genomic Locations for NFKB2 Gene
- chr10:102,394,110-102,402,529
- (GRCh38/hg38)
- Size:
- 8,420 bases
- Orientation:
- Plus strand
- chr10:104,153,867-104,162,281
- (GRCh37/hg19)
Genomic View for NFKB2 Gene
- Cytogenetic band:
-
- 10q24.32 by Ensembl
- 10q24.32 by Entrez Gene
- 10q24.32 by HGNC


RefSeq DNA sequence for NFKB2 Gene
Proteins for NFKB2 Gene
-
Protein details for NFKB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q00653-NFKB2_HUMAN
- Recommended name:
- Nuclear factor NF-kappa-B p100 subunit
- Protein Accession:
- Q00653
- A8K9D9
- D3DR83
- Q04860
- Q9BU75
- Q9H471
- Q9H472
Protein attributes for NFKB2 Gene
- Size:
- 900 amino acids
- Molecular mass:
- 96749 Da
- Quaternary structure:
-
- Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.
- SequenceCaution:
-
- Sequence=CAA43715.1; Type=Frameshift; Positions=456, 458, 470, 900; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NFKB2 Gene
Protein Expression for NFKB2 Gene
Post-translational modifications for NFKB2 Gene
- Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain.
- Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its proteasome-dependent processing.
- While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
- Ubiquitination at isoforms=4855
Other Protein References for NFKB2 Gene
Antibody Products
- R&D Systems Antibodies for NFKB2 (NFkB2)
- Novus Biologicals Antibodies for NFKB2
-
Cloud-Clone Corp. Antibodies for NFKB2
- Invitrogen Antibodies for NFKB2
- GeneTex NFKB2 antibody for NFKB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NFKB2
- Sino Biological Antibodies for NFKB2
Protein Products
-
OriGene Purified Proteins for NFKB2
- Search Origene for MassSpec and Protein Over-expression Lysates for NFKB2
- Origene Custom Protein Services for NFKB2
- Novus Biologicals proteins for NFKB2
-
Cloud-Clone Corp. Proteins for NFKB2
- Search GeneTex for Proteins for NFKB2
-
Abcam proteins for NFKB2
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for NFKB2 (NFkB2)
-
Cloud-Clone Corp. Assay Kits for NFKB2
-
Abcam assays for NFKB2
No data available for DME Specific Peptides for NFKB2 Gene
Domains & Families for NFKB2 Gene
Gene Families for NFKB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NFKB2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NFKB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q00653UniProtKB/Swiss-Prot:
NFKB2_HUMAN :- The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.
- Domain:
-
- The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.
- The glycine-rich region (GRR) appears to be a critical element in the generation of p52.
Function for NFKB2 Gene
Molecular function for NFKB2 Gene
- GENATLAS Biochemistry:
- nuclear transcription factor of kappa light chain gene enhancer in B cells,2,(encoding the p100 precursor and the amino-terminal active p52(p49)subunit),NF-kappa B/REL family
- UniProtKB/Swiss-Prot Function:
- NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5-GGRNNYYCC-3, located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Phenotypes From GWAS Catalog for NFKB2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 12835724 |
GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 12835724 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IBA | -- |
GO:0003700 | DNA binding transcription factor activity | TAS | 1760839 |
Phenotypes for NFKB2 Gene
- MGI mutant phenotypes for NFKB2:
-
inferred from 7 alleles
- homeostasis/metabolism phenotype
- respiratory system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for NFKB2:
Animal Models for NFKB2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NFKB2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NFKB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NFKB2 gene
- Search ViGene Biosciences for NFKB2
CRISPR Products
-
OriGene CRISPR knockouts for NFKB2
- genomics-online: gRNA clones - Search results for available NFKB2 gene related products
- Applied Biological Materials CRISPR for NFKB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NFKB2
- GenScript: Design CRISPR guide RNA sequences for NFKB2
miRNA for NFKB2 Gene
- miRTarBase miRNAs that target NFKB2
miRNA Products
- Search ViGene Biosciences for NFKB2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NFKB2
- Browse OriGene Inhibitory RNA Products For NFKB2
- genomics-online: shRNA clones - Search results for available NFKB2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NFKB2 gene
Clone Products
-
OriGene ORF clones in human for NFKB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NFKB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NFKB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NFKB2
- genomics-online: cdna clones - Search results for available NFKB2 gene related products
- orf clones - Search results for available NFKB2 gene related products
- Applied Biological Materials Clones for NFKB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NFKB2
-
ViGene Biosciences adenoviral particle packaged cDNA for NFKB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NFKB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NFKB2 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NFKB2 Gene
Localization for NFKB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NFKB2 Gene
- Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
- Cytosol (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 15677444 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IDA | 15677444 |
GO:0005829 | cytosol | TAS,IBA | -- |
GO:0033257 | Bcl3/NF-kappaB2 complex | IDA | 9407099 |
Pathways & Interactions for NFKB2 Gene
Pathways by source for NFKB2 Gene
2 GeneTex pathways for NFKB2 Gene
1 Cell Signaling Technology pathway for NFKB2 Gene
15 BioSystems pathways for NFKB2 Gene
42 Reactome pathways for NFKB2 Gene
2 PharmGKB pathways for NFKB2 Gene
9 KEGG pathways for NFKB2 Gene
47 GeneGo (Thomson Reuters) pathways for NFKB2 Gene
10 R&D Systems pathways for NFKB2 Gene
4 Tocris pathways for NFKB2 Gene
2 Qiagen pathways for NFKB2 Gene
Interacting Proteins for NFKB2 Gene
SIGNOR curated interactions for NFKB2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
GO:0002268 | follicular dendritic cell differentiation | IEA | -- |
GO:0002467 | germinal center formation | IEA | -- |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IDA | 8360178 |
Drugs & Compounds for NFKB2 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target, antagonist | 1232 | ||
Glucosamine | Approved, Investigational | Nutra | Target, antagonist | 211 | ||
Sulfasalazine | Approved | Pharma | Inhibition, Inhibitor | NF-κB activation inhibitor | 63 | |
Andrographolide | Investigational | Pharma | Target | NF-κB signaling Inhibitor | 10 | |
Custirsen | Investigational | Pharma | Target | Others | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
(3) Tocris Compounds for NFKB2 Gene
Compound | Action | Cas Number |
---|---|---|
Pyrrolidinedithiocarbamate ammonium | Inhibits NF-kappaB, prevents increase in NOS mRNA | 5108-96-3 |
SP 100030 | NF-kappaB and AP-1 dual inhibitor | 154563-54-9 |
Tanshinone IIA | Inhibits NF-kappaB and AP-1 DNA binding. Displays antioxidant properties | 568-72-9 |
(23) ApexBio Compounds for NFKB2 Gene
Compound | Action | Cas Number |
---|---|---|
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid | 317318-70-0 | |
Andrographolide | NF-κB signaling Inhibitor | 5508-58-7 |
Bay 11-7085 | NK-κB activation inhibitor | 196309-76-9 |
Bay 11-7821(BAY 11-7082) | IKK/NF-κB/TNFα inhibitor | 19542-67-7 |
Caffeic Acid Phenethyl Ester | NF-κB activation inhibitor | 104594-70-9 |
Emodin | Naturally occurring anthraquinone,antiproliferative | 518-82-1 |
Honokiol | Antioxidant/antitumor/antiangiogenic agent | 35354-74-6 |
IKK-16 (IKK Inhibitor VII) | Selective IκB kinase inhibitor | 873225-46-8 |
IMD 0354 | 978-62-1 | |
JSH-23 | NF-κB inhibitor | 749886-87-1 |
Kaempferol | Apoptosis inducer;antioxidant;flavonoid | 520-18-3 |
Luteolin | Antioxidant and free radical scavenger | 491-70-3 |
Matrine | Alkaloid found in Sophora plant | 519-02-8 |
QNZ (EVP4593) | Potent NF-κB inhibitor | 545380-34-5 |
SC75741 | 913822-46-5 | |
Sodium 4-Aminosalicylate | 6018-19-5 | |
Sodium salicylate | 54-21-7 | |
Sulfasalazine | NF-κB activation inhibitor | 599-79-1 |
Tanshinone IIA | Antioxidant and anti-inflammatory reagent | 568-72-9 |
TPCA-1 | IKK-2 inhibitor,potent and selective | 507475-17-4 |
Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Verbascoside | PKC/NF-κB inhibitor | 61276-17-3 |
WS6 | 1421227-53-3 |
Transcripts for NFKB2 Gene
mRNA/cDNA for NFKB2 Gene
- (9) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (151) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NFKB2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NFKB2
- genomics-online: gRNA clones - Search results for available NFKB2 gene related products
- Applied Biological Materials CRISPR for NFKB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NFKB2
- GenScript: Design CRISPR guide RNA sequences for NFKB2
miRNA Products
- Search ViGene Biosciences for NFKB2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NFKB2
- Browse OriGene Inhibitory RNA Products For NFKB2
- genomics-online: shRNA clones - Search results for available NFKB2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NFKB2 gene
Clone Products
-
OriGene ORF clones in human for NFKB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NFKB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NFKB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NFKB2
- genomics-online: cdna clones - Search results for available NFKB2 gene related products
- orf clones - Search results for available NFKB2 gene related products
- Applied Biological Materials Clones for NFKB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
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SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||
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SP7: | |||||||||||||||||||||||||||
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SP9: | |||||||||||||||||||||||||||
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SP11: | |||||||||||||||||||||||||||
SP12: |
Expression for NFKB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for NFKB2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFKB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NFKB2 Gene:
NFKB2SOURCE GeneReport for Unigene cluster for NFKB2 Gene:
Hs.73090Evidence on tissue expression from TISSUES for NFKB2 Gene
- Liver(4.3)
- Blood(2.5)
- Lymph node(2.4)
- Bone marrow(2.2)
- Lung(2.2)
- Spleen(2.2)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NFKB2 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- brain
- ear
- eye
- head
- hypothalamus
- meninges
- middle ear
- neck
- pituitary gland
- sinus
- skull
- thyroid
- bronchus
- heart
- lung
- adrenal gland
- intestine
- large intestine
- liver
- small intestine
- spleen
- stomach
- anus
- rectum
- uterus
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
- blood
- blood vessel
- bone marrow
- coagulation system
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for NFKB2
- genomics-online: primer clones - Search results for available NFKB2 gene related products
No data available for mRNA Expression by UniProt/SwissProt for NFKB2 Gene
Orthologs for NFKB2 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NFKB2 34 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
dog (Canis familiaris) |
Mammalia | NFKB2 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | NFKB2 34 33 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Nfkb2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Nfkb2 34 16 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | NFKB2 34 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | NFKB2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | nfkb2 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | nfkb2 34 33 |
|
OneToOne | |
wufa03b02 33 |
|
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African malaria mosquito (Anopheles gambiae) |
Insecta | REL2 33 |
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fruit fly (Drosophila melanogaster) |
Insecta | dl 35 |
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Dif 35 |
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Rel 34 35 |
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OneToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1675 34 |
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OneToMany |
- Species where no ortholog for NFKB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NFKB2 Gene
(5) SIMAP similar genes for NFKB2 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for NFKB2 Gene
Variants for NFKB2 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11191279 | benign, Common variable immunodeficiency 10 | 102,401,464(+) | C/T | coding_sequence_variant, synonymous_variant | |
rs11574851 | benign, Common variable immunodeficiency 10 | 102,401,202(+) | C/T | coding_sequence_variant, synonymous_variant | |
rs11574853 | benign, not specified, Common variable immunodeficiency 10 | 102,402,039(+) | T/A | intron_variant | |
rs138786808 | benign, Common variable immunodeficiency 10 | 102,400,725(+) | G/A | coding_sequence_variant, synonymous_variant | |
rs201550645 | likely-benign, Common variable immunodeficiency 10 | 102,401,177(+) | C/T | intron_variant |
Additional Variant Information for NFKB2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFKB2 Gene
Disorders for NFKB2 Gene

(6) MalaCards diseases for NFKB2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency, common variable, 10 |
|
|
immunodeficiency, common variable, 1 |
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common variable immunodeficiency |
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b cell deficiency |
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acth deficiency, isolated |
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|
UniProtKB/Swiss-Prot
NFKB2_HUMAN- Immunodeficiency, common variable, 10 (CVID10) [MIM:615577]: A primary immunodeficiency characterized by childhood-onset of recurrent infections, hypogammaglobulinemia, and decreased numbers of memory and marginal zone B-cells. Some patients may develop autoimmune features and have circulating autoantibodies. An unusual feature is central adrenal insufficiency. {ECO:0000269 PubMed:24140114, ECO:0000269 PubMed:25524009}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL). Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant.
- Note=A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line. This rearrangement produces the p80HT gene which codes for a truncated 80 kDa protein (p80HT).
- Note=In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal aberrations, such as internal deletions.
Genatlas disease for NFKB2 Gene
Additional Disease Information for NFKB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for NFKB2 Gene
- Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PMID: 18434448) Dieguez-Gonzalez R … Gonzalez A (Annals of the rheumatic diseases 2009) 3 22 44 58
- The generation of nfkb2 p52: mechanism and efficiency. (PMID: 10597218) Heusch M … Greene WC (Oncogene 1999) 3 4 22 58
- Structural and functional characterization of the promoter regions of the NFKB2 gene. (PMID: 7541912) Lombardi L … Neri A (Nucleic acids research 1995) 3 4 22 58
- Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies. (PMID: 7949142) Migliazza A … Neri A (Blood 1994) 3 4 22 58
- Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells. (PMID: 8036016) Thakur S … Rabson AB (Oncogene 1994) 3 4 22 58
Products for NFKB2 Gene
- R&D Systems Antibodies for NFKB2 (NFkB2)
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- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for NFKB2 (NFkB2)
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- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for NFKB2
- Browse OriGene ELISA Kits
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- OriGene Purified Proteins for NFKB2
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for NFKB2
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- OriGene qPCR primer pairs for NFKB2
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- OriGene ORF clones in human for NFKB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NFKB2
- GenScript: Next-day shipping of latest version cDNA ORF clones for NFKB2 in any vector
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- GenScript: Design CRISPR guide RNA sequences for NFKB2
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NFKB2
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam proteins for NFKB2
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- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for NFKB2
- Cloud-Clone Corp. Proteins for NFKB2
- Cloud-Clone Corp. Assay Kits for NFKB2
- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NFKB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for NFKB2
- Cyagen custom Knockout/knockin (KOKI) mouse models for NFKB2
- VectorBuilder custom plasmid, inducible vectors for NFKB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NFKB2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NFKB2
- antibodies-online: Search results for available NFKB2 related products ranked by validation data
- antibodies-online: Search results for available NFKB2 related products ranked by validation data
- antibodies-online: Search results for available NFKB2 related products ranked by validation data
- GeneTex NFKB2 antibody for NFKB2
- Search GeneTex for Proteins for NFKB2
- ViGene Biosciences adenoviral particle packaged cDNA for NFKB2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NFKB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NFKB2 gene
- Search ViGene Biosciences for NFKB2
- Santa Cruz Biotechnology (SCBT) Antibodies for NFKB2
- Search Santa Cruz Biotechnology (SCBT) for NFKB2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NFKB2
- Horizon Cell Lines for NFKB2
- genomics-online: cdna clones - Search results for available NFKB2 gene related products
- orf clones - Search results for available NFKB2 gene related products
- genomics-online: gRNA clones - Search results for available NFKB2 gene related products
- genomics-online: primer clones - Search results for available NFKB2 gene related products
- genomics-online: shRNA clones - Search results for available NFKB2 gene related products
Sources for NFKB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144)