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Aliases for NFKB2 Gene

Aliases for NFKB2 Gene

  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2 (P49/P100) 2 3
  • Oncogene Lyt-10 3 4 6
  • Lymphocyte Translocation Chromosome 10 Protein 3 4
  • DNA-Binding Factor KBF2 3 4
  • LYT10 3 4
  • H2TF1 3 4
  • Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2 4
  • Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells 2 3
  • Nuclear Factor NF-Kappa-B P100 Subunit 3
  • Nuclear Factor NF-Kappa-B P52 Subunit 3
  • Nuclear Factor Kappa-B, Subunit 2 3
  • Transcription Factor NFKB2 3
  • NFKB, P52/P100 Subunit 3
  • LYT-10 3
  • NF-KB2 3
  • CVID10 3
  • P100 3
  • P52 3

External Ids for NFKB2 Gene

Summaries for NFKB2 Gene

Entrez Gene Summary for NFKB2 Gene

  • This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for NFKB2 Gene

NFKB2 (Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2 (P49/P100)) is a Protein Coding gene. Diseases associated with NFKB2 include b-cell lymphomas and immunodeficiency, common variable, 10. Among its related pathways are MAPK signaling pathway and Pathways in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot for NFKB2 Gene

  • NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5-GGRNNYYCC-3, located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Tocris Summary for NFKB2 Gene

  • NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immune response to infection. In unstimulated cells NF-kappaB dimers are sequestered inactively in the cytoplasm by a protein complex called inhibitor of kappa B (IkappaB). IkappaB inactivates NF-kappaB by masking the nuclear localization signals (NLS). Activation of NF-kappaB occurs via degradation of IkappaB, a process that is initiated by its phosphorylation by IkappaB kinase (IKK). Phosphorylated IvB becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation also results in IkappaB ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus and regulate gene expression. NF-kappaB turns on expression of IkappaB forming a negative feedback loop.

Gene Wiki entry for NFKB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFKB2 Gene

Genomics for NFKB2 Gene

Genomic Location for NFKB2 Gene

Start:
102,394,110 bp from pter
End:
102,402,529 bp from pter
Size:
8,420 bases
Orientation:
Plus strand

Genomic View for NFKB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFKB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFKB2 Gene

Regulatory Elements for NFKB2 Gene

Transcription factor binding sites by QIAGEN in the NFKB2 gene promoter:

Proteins for NFKB2 Gene

  • Protein details for NFKB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00653-NFKB2_HUMAN
    Recommended name:
    Nuclear factor NF-kappa-B p100 subunit
    Protein Accession:
    Q00653
    Secondary Accessions:
    • A8K9D9
    • D3DR83
    • Q04860
    • Q9BU75
    • Q9H471
    • Q9H472

    Protein attributes for NFKB2 Gene

    Size:
    900 amino acids
    Molecular mass:
    96749 Da
    Quaternary structure:
    • Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.
    SequenceCaution:
    • Sequence=CAA43715.1; Type=Frameshift; Positions=456, 458, 470, 900; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFKB2 Gene

    Alternative splice isoforms for NFKB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFKB2 Gene

Proteomics data for NFKB2 Gene at MOPED

Post-translational modifications for NFKB2 Gene

  • Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain
  • Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its proteasome-dependent processing.
  • While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys855

Other Protein References for NFKB2 Gene

No data available for DME Specific Peptides for NFKB2 Gene

Domains for NFKB2 Gene

Gene Families for NFKB2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

UniProtKB/Swiss-Prot:

NFKB2_HUMAN
Domain:
  • The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.:
    • Q00653
  • The glycine-rich region (GRR) appears to be a critical element in the generation of p52:
    • Q00653
  • Contains 1 death domain.:
    • Q00653
  • Contains 1 RHD (Rel-like) domain.:
    • Q00653
Similarity:
  • Contains 7 ANK repeats.:
    • Q00653
genes like me logo Genes that share domains with NFKB2: view

Function for NFKB2 Gene

Molecular function for NFKB2 Gene

GENATLAS Biochemistry: nuclear transcription factor of kappa light chain gene enhancer in B cells,2,(encoding the p100 precursor and the amino-terminal active p52(p49)subunit),NF-kappa B/REL family
UniProtKB/Swiss-Prot Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5-GGRNNYYCC-3, located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Gene Ontology (GO) - Molecular Function for NFKB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12835724
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 12835724
GO:0003677 DNA binding --
GO:0003682 chromatin binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1760839
genes like me logo Genes that share ontologies with NFKB2: view
genes like me logo Genes that share phenotypes with NFKB2: view

Animal Models for NFKB2 Gene

MGI Knock Outs for NFKB2:

miRNA for NFKB2 Gene

miRTarBase miRNAs that target NFKB2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NFKB2 Gene

Localization for NFKB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFKB2 Gene

Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFKB2 Gene COMPARTMENTS Subcellular localization image for NFKB2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NFKB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15677444
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0033257 Bcl3/NF-kappaB2 complex IDA 9407099
genes like me logo Genes that share ontologies with NFKB2: view

Pathways for NFKB2 Gene

SuperPathways for NFKB2 Gene

genes like me logo Genes that share pathways with NFKB2: view

Pathways by source for NFKB2 Gene

Gene Ontology (GO) - Biological Process for NFKB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002268 follicular dendritic cell differentiation IEA --
GO:0002467 germinal center formation IEA --
genes like me logo Genes that share ontologies with NFKB2: view

Compounds for NFKB2 Gene

(5) Tocris Compounds for NFKB2 Gene

Compound Action Cas Number
Bay 11-7085 Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation [196309-76-9]
Celastrol Inhibits TNF-alpha-induced NF-kappaB activation [34157-83-0]
IMD 0354 Inhibitor of IKKbeta [978-62-1]
Ro 106-9920 Inhibitor of NF-kappaB activation [62645-28-7]
SC 514 IKKbeta inhibitor; attenuates NF-kappaB-induced gene expression [354812-17-2]

(1) Drugbank Compounds for NFKB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glucosamine
3416-24-8 target antagonist

(1) Novoseek inferred chemical compound relationships for NFKB2 Gene

Compound -log(P) Hits PubMed IDs
chloramphenicol 23.7 1
genes like me logo Genes that share compounds with NFKB2: view

Transcripts for NFKB2 Gene

Unigene Clusters for NFKB2 Gene

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFKB2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - -
SP2: -
SP3: -
SP4:
SP5: - -
SP6:
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:

ExUns: 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NFKB2 Gene

GeneLoc Exon Structure for
NFKB2
ECgene alternative splicing isoforms for
NFKB2

Expression for NFKB2 Gene

mRNA expression in normal human tissues for NFKB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFKB2 Gene

This gene is overexpressed in Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFKB2 Gene

SOURCE GeneReport for Unigene cluster for NFKB2 Gene Hs.73090

genes like me logo Genes that share expressions with NFKB2: view

Orthologs for NFKB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFKB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFKB2 36
  • 99.7 (n)
  • 99.85 (a)
NFKB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFKB2 36
  • 89.28 (n)
  • 91.77 (a)
NFKB2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFKB2 36
  • 89.56 (n)
  • 92.11 (a)
NFKB2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfkb2 36
  • 86.52 (n)
  • 91.89 (a)
Nfkb2 16
Nfkb2 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 77 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nfkb2 36
  • 86.82 (n)
  • 91.09 (a)
chicken
(Gallus gallus)
Aves NFKB2 36
  • 67.31 (n)
  • 67.42 (a)
NFKB2 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFKB2 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfkb2 36
  • 58.74 (n)
  • 57.54 (a)
zebrafish
(Danio rerio)
Actinopterygii nfkb2 36
  • 55.9 (n)
  • 52.87 (a)
nfkb2 37
  • 48 (a)
OneToOne
wufa03b02 36
African malaria mosquito
(Anopheles gambiae)
Insecta REL2 36
  • 47.5 (n)
  • 34.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rel 37
  • 21 (a)
OneToMany
dl 38
  • 41 (a)
Dif 38
  • 36 (a)
Rel 38
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1675 37
  • 27 (a)
OneToMany
Species with no ortholog for NFKB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFKB2 Gene

ENSEMBL:
Gene Tree for NFKB2 (if available)
TreeFam:
Gene Tree for NFKB2 (if available)

Paralogs for NFKB2 Gene

Paralogs for NFKB2 Gene

Selected SIMAP similar genes for NFKB2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NFKB2 Gene

genes like me logo Genes that share paralogs with NFKB2: view

Variants for NFKB2 Gene

Sequence variations from dbSNP and Humsavar for NFKB2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1005044 -- 102,392,386(+) GCAAC(A/C)CACCC upstream-variant-2KB
rs1048961 -- 102,398,945(+) gtggt(G/T)gctca intron-variant
rs1572532 -- 102,394,926(-) TGTAC(A/G)GACAC intron-variant, upstream-variant-2KB
rs2295587 -- 102,398,510(+) TATTA(C/T)CCTCT reference, synonymous-codon
rs3188993 -- 102,397,662(+) AGTCA(C/T)CTCCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for NFKB2 Gene

Variant ID Type Subtype PubMed ID
nsv526665 CNV Loss 19592680
nsv525546 CNV Loss 19592680
nsv895970 CNV Loss 21882294
dgv814n71 CNV Loss 21882294
dgv815n71 CNV Loss 21882294

Relevant External Links for NFKB2 Gene

HapMap Linkage Disequilibrium report
NFKB2
Human Gene Mutation Database (HGMD)
NFKB2

Disorders for NFKB2 Gene

(1) OMIM Diseases for NFKB2 Gene (164012)

UniProtKB/Swiss-Prot

NFKB2_HUMAN
  • Note=A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL). Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant.
  • Note=A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line. This rearrangement produces the p80HT gene which codes for a truncated 80 kDa protein (p80HT).
  • Note=In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal aberrations, such as internal deletions.
  • Immunodeficiency, common variable, 10 (CVID10) [MIM:615577]: A primary immunodeficiency characterized by childhood-onset of recurrent infections, hypogammaglobulinemia, and decreased numbers of memory and marginal zone B-cells. Some patients may develop autoimmune features and have circulating autoantibodies. An unusual feature is central adrenal insufficiency. {ECO:0000269 PubMed:24140114}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(8) Novoseek inferred disease relationships for NFKB2 Gene

Disease -log(P) Hits PubMed IDs
lymphoid neoplasm 68.9 3
lymphoma t-cell 57 1
lymphoma 41.3 4
lymphoma b-cell 37.4 1
myeloma 25.2 1

Genatlas disease for NFKB2 Gene

lymphoma,B cell,non Hodgkin,associated with breakpoint in t(10;14)(q24;q32) translocation

Relevant External Links for NFKB2

Genetic Association Database (GAD)
NFKB2
Human Genome Epidemiology (HuGE) Navigator
NFKB2
Tumor Gene Database (TGDB):
NFKB2
genes like me logo Genes that share disorders with NFKB2: view

Publications for NFKB2 Gene

  1. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. (PMID: 1760839) Neri A. … Dalla-Favera R. (Cell 1991) 3 4 23
  2. Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies. (PMID: 7949142) Migliazza A. … Neri A. (Blood 1994) 3 4 23
  3. Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells. (PMID: 8036016) Thakur S. … Rabson A.B. (Oncogene 1994) 3 4 23
  4. Structural and functional characterization of the promoter regions of the NFKB2 gene. (PMID: 7541912) Lombardi L. … Neri A. (Nucleic Acids Res. 1995) 3 4 23
  5. Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene. (PMID: 8360178) Potter D.A. … Sharp P.A. (J. Biol. Chem. 1993) 3 4 23

Products for NFKB2 Gene

  • Addgene plasmids for NFKB2

Sources for NFKB2 Gene

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