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NFKB2 Gene

protein-coding   GIFtS: 70
GCID: GC10P104144

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...

  See NFKB2-related diseases
at
MalaCards
 

Aliases
for NFKB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2
(P49/P100)1 2
     NFKB, P52/P100 Subunit2
LYT102 3 5     Nuclear Factor Kappa-B, Subunit 22
Lymphocyte Translocation Chromosome 10 Protein2 3     Nuclear Factor NF-Kappa-B P100 Subunit2
Oncogene Lyt-102 3     Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells 22
H2TF12 3     p1052
DNA-Binding Factor KBF22 3     p522
CVID102 5     Transcription Factor NFKB22
LYT-102     Lyt103
NF-kB22     Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 23

External Ids:    HGNC: 77951   Entrez Gene: 47912   Ensembl: ENSG000000771507   OMIM: 1640125   UniProtKB: Q006533   

Export aliases for NFKB2 gene to outside databases

Previous GC identifers: GC10P103047 GC10P103387 GC10P104285 GC10P103818 GC10P097787


Summaries
for NFKB2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NFKB2 Gene:
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is
expressed in numerous cell types and functions as a central activator of genes involved in inflammation and
immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor
depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52
active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas,
some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome
18. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2013)

GeneCards Summary for NFKB2 Gene:
NFKB2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)) is a protein-coding gene. Diseases associated with NFKB2 include immunodeficiency, common variable, 10, and b-cell lymphomas. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKB1.

UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653
Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of
a series of signal transduction events that are initiated by a vast array of stimuli related to many biological
processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B
is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,
NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the
individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable
affinity and specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular
compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are
held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.
In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to
different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to
the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates
NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B
RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B
p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic
retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The
proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in
immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing
of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the
HIV enhancer in synergy with p65

summary for NFKB2 Gene:
NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types.
It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in
regulating the immune response to infection. In unstimulated cells NF-kappaB dimers are sequestered
inactively in the cytoplasm by a protein complex called inhibitor of kappa B (IkappaB). IkappaB inactivates
NF-kappaB by masking the nuclear localization signals (NLS). Activation of NF-kappaB occurs via degradation
of IkappaB, a process that is initiated by its phosphorylation by IkappaB kinase (IKK). Phosphorylated IvB
becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation also results in IkappaB
ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus and regulate gene
expression. NF-kappaB turns on expression of IkappaB forming a negative feedback loop.

Gene Wiki entry for NFKB2 Gene


Genomic Views
for NFKB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFKB2 gene promoter:
         p53   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NFKB2 promoter sequence
   Search Chromatin IP Primers for NFKB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFKB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24

NFKB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKB2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104144:  view genomic region     (about GC identifiers)

Start:
 104,153,867 bp from pter      End:
 104,162,281 bp from pter
Size:
 8,415 bases      Orientation:
 plus strand

Proteins
for NFKB2 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section
UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653 (See protein sequence)
Recommended Name: Nuclear factor NF-kappa-B p100 subunit  
Size: 900 amino acids; 96749 Da
Subunit: Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex.
Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts
with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts
with MEN1
Sequence caution: Sequence=CAA43715.1; Type=Frameshift; Positions=456, 458, 470, 900;
3 PDB 3D structures from and Proteopedia for NFKB2:
1A3Q (3D)        2D96 (3D)        3DO7 (3D)    
Secondary accessions: A8K9D9 D3DR83 Q04860 Q9BU75 Q9H471 Q9H472
Alternative splicing: 3 isoforms:  Q00653-1   Q00653-3   Q00653-4   (Ref.1 (CAA43716.1) sequence(s) differ(s) from that shown due to frameshifts in positions 407, 414)

Explore the universe of human proteins at neXtProt for NFKB2: NX_Q00653

Explore proteomics data for NFKB2 at MOPED

Post-translational modifications: 

  • While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52
    making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The
    processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form
    cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of
    the GRR repeat precludes processing1
  • Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its
    proteasome-dependent processing1
  • Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which
    contains the death domain1
  • Ubiquitination2 at Lys855
  • Modification sites at PhosphoSitePlus

    • See NFKB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001070962.1  NP_001248332.1  NP_001275653.1  NP_002493.3  

    ENSEMBL proteins: 
     ENSP00000470826   ENSP00000358983   ENSP00000471586   ENSP00000189444   ENSP00000410256  
    Reactome Protein details: Q00653

    NFKB2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant NFKB2 Protein
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    OriGene Protein Over-expression Lysate for NFKB2
    OriGene MassSpec for NFKB2
    OriGene Custom Protein Services for NFKB2
    GenScript Custom Purified and Recombinant Proteins Services for NFKB2
    Novus Biologicals NFKB2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

         		 Search eBioscience for Proteins for NFKB2 

         		 Search GeneTex for Proteins for NFKB2 

         		antibodies-online proteins for NFKB2 (4 products) 

         		antibodies-online peptides for NFKB2

    NFKB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NFKB2
    R&D Systems Antibodies for NFKB2
    Cell Signaling Technology (CST) Antibodies for NFKB2  (NFkB-p100)
    OriGene Antibodies for NFKB2
    OriGene Custom Antibody Services for NFKB2
    Novus Biologicals NFKB2 Antibodies
    Abcam antibodies for NFKB2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for NFKB2
    antibodies-online antibodies for NFKB2 (104 products) 

    NFKB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFKB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFKB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NFKB2 
    antibodies-online kits for NFKB2 (7 products) 

    Domains /
    Families
    for NFKB2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    		 HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 10):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR011029 DEATH-like_dom
     IPR002909 IPT
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q00653

    ProtoNet protein and cluster: Q00653

    5 Blocks protein domains:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB000488 Death domain
    IPB002110 Ankyrin repeat signature
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653
    Domain: The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52
    homodimers, and/or transcription activation (By similarity)
    Domain: The glycine-rich region (GRR) appears to be a critical element in the generation of p52
    Similarity: Contains 7 ANK repeats
    Similarity: Contains 1 death domain
    Similarity: Contains 1 RHD (Rel-like) domain


    Find genes that share domains with NFKB2           About GenesLikeMe


    Function
    for NFKB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFKB2_HUMAN, Q00653
    Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of
    a series of signal transduction events that are initiated by a vast array of stimuli related to many biological
    processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B
    is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,
    NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the
    individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable
    affinity and specificity. Different dimer combinations act as transcriptional activators or repressors,
    respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular
    compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are
    held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.
    In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to
    different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to
    the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates
    NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B
    RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B
    p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic
    retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The
    proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
    p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in
    immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing
    of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the
    HIV enhancer in synergy with p65

         Genatlas biochemistry entry for NFKB2:
    nuclear transcription factor of kappa light chain gene enhancer in B cells,2,(encoding the p100 precursor and the
    amino-terminal active p52(p49)subunit),NF-kappa B/REL family

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS1876189
    GO:0005515protein binding IPI11239468
         
    Find genes that share ontologies with NFKB2           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Nfkb2):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system  reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with NFKB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NFKB2: Nfkb2tm1Sbn Nfkb2tm1Brv Nfkb2tm1Rsch Nfkb2tm2Brv

       genOway: Develop your customized and physiologically relevant rodent model for NFKB2

    miRNA
    Products:            		miRTarBase miRNAs that target NFKB2:
    hsa-mir-98-5p (MIRT027644), hsa-mir-193b-3p (MIRT016350), hsa-mir-423-5p (MIRT038120)

    Block miRNA regulation of human, mouse, rat NFKB2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NFKB2:
    hsa-miR-501-5p hsa-let-7g* hsa-miR-1914* hsa-let-7a-2* hsa-miR-500a hsa-miR-609
    SwitchGear 3'UTR luciferase reporter plasmid: NFKB2 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for NFKB2
    Predesigned siRNA for gene silencing in human, mouse, rat NFKB2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NFKB2

    Clone
    Products:             		 OriGene clones in human, mouse for NFKB2 (see all 18)
    OriGene ORF clones in mouse, rat for NFKB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NFKB2 (NM_002502)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKB2
    Addgene plasmids for NFKB2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NFKB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFKB2 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKB2


    Localization
    for NFKB2 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section
    Subcellular locations from UniProtKB/Swiss-Prot
    NFKB2_HUMAN, Q00653: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form
    complexed to an inhibitor (I-kappa-B)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with NFKB2           About GenesLikeMe


    Pathways & Interactions
    for NFKB2 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section





    SuperPaths for NFKB2 About   (see all 61)  
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    		NOD-like Receptor Signaling Pathways0.58
    		Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    		Toll-Like receptor Signaling Pathways0.58
    		Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.32
    		Inflammasome Activation Pathways0.51
    		Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    		IL-1 Family Signaling Pathways0.44
    2IL-17 Family Signaling Pathways
    		IL-17 Family Signaling Pathways0.51
    		Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    3LT-BetaR Pathway
    		LT-BetaR Pathway0.46
    		Apoptosis and survival Lymphotoxin-beta receptor signaling0.46
    4IL12-mediated signaling events
    		Immune response IL-12-induced IFN-gamma production0.31
    		IL12-mediated signaling events0.31
    5RANK Signaling in Osteoclasts
    		Apoptosis and survival APRIL and BAFF signaling0.39
    		RANKL/RANK Signaling Pathway0.31


    Find genes that share SuperPaths with NFKB2           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for NFKB2 (see all 8)
        Inflammasome Activation Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    Notch Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NFKB2
        LT-BetaR Pathway
    NF-KappaB Family Pathway

    1 Cell Signaling Technology (CST) Pathway for NFKB2
        NF-kappaB Signaling

    4 Tocris Bioscience Pathways for NFKB2
        Akt Pathway
    Apoptosis Pathway
    Toll-like Receptor Pathway
    NF-kappaB Pathway

    Selected GeneGo (Thomson Reuters) Pathways for NFKB2 (see all 47)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for NFKB2 (see all 15)
        EBV LMP1 signaling
    DNA damage response (only ATM dependent)
    SIDS Susceptibility Pathways
    Neural Crest Differentiation
    Selenium Pathway

    5 Reactome Pathways for NFKB2
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    Interleukin-1 processing
    RIP-mediated NFkB activation via ZBP1
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex
    TRAF6 mediated NF-kB activation

    2 PharmGKB Pathways for NFKB2
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for NFKB2) (see all 8):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Osteoclast differentiation
    Legionellosis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFKB2 (see all 7): 
              NFKB Signaling Targets in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFKB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFKB2 (Q006531, 2, 3 ENSP000001894444) via UniProtKB, MINT, STRING, and/or I2D (see all 237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198381, 2, 3, ENSP000002265744EBI-307326,EBI-300010 MINT-48553 MINT-6178467 MINT-6178504 MINT-47910 MINT-48724 MINT-6178544 MINT-48674 MINT-48585 MINT-47890 MINT-6178520 MINT-47923 MINT-6178488 I2D: score=8 STRING: ENSP00000226574
    RELBQ012011, 2, 3, ENSP000002214524EBI-307326,EBI-357837 MINT-49015 MINT-6178544 MINT-48631 MINT-48776 MINT-6178520 MINT-48018 MINT-47926 MINT-6178488 I2D: score=8 STRING: ENSP00000221452
    RELQ048641, 2, 3, ENSP000002950254EBI-307326,EBI-307352 MINT-48598 MINT-6178520 MINT-47915 MINT-48733 MINT-6178504 MINT-47893 MINT-6178544 I2D: score=6 STRING: ENSP00000295025
    RELAQ042062, 3, ENSP000003842734MINT-6178467 MINT-47896 MINT-48764 MINT-47925 MINT-48623 MINT-48943 MINT-6178544 MINT-6178520 I2D: score=8 STRING: ENSP00000384273
    ENSG00000183311P074372, 3MINT-48608 MINT-48739 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002268follicular dendritic cell differentiation IEA--
    GO:0002467germinal center formation IEA--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with NFKB2           About GenesLikeMe



    Drugs & Compounds
    for NFKB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NFKB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SC 514IKKbeta inhibitor; attenuates NF-kappaB-induced gene expression[354812-17-2]
    Ro 106-9920Inhibitor of NF-kappaB activation[62645-28-7]
    IMD 0354Inhibitor of IKKbeta[978-62-1]
    CelastrolInhibits TNF-alpha-induced NF-kappaB activation[34157-83-0]
    Bay 11-7085Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation[196309-76-9]

    1 DrugBank Compound for NFKB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glucosamine-- 3416-24-8targetantagonist12681956

    1 Novoseek inferred chemical compound relationship for NFKB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 23.7 1 9523851 (1)



    Find genes that share compounds with NFKB2           About GenesLikeMe



    Transcripts
    for NFKB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section
    REFSEQ mRNAs for NFKB2 gene (7 alternative transcripts): 
    NM_001077494.3  NM_001261403.2  NM_001288724.1  NM_002502.5  XM_005269860.1  XM_005269861.2  XM_006717869.1  

    Unigene Cluster for NFKB2:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
    Hs.73090  [show with all ESTs]
    Unigene Representative Sequence: NR_048560
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593908 ENST00000601386 ENST00000369966(uc001kvb.3) ENST00000471698
    ENST00000467116(uc010qqk.1) ENST00000189444(uc009xxc.3) ENST00000336486(uc001kvd.3)
    ENST00000473400 ENST00000428099(uc001kva.3)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat NFKB2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NFKB2:
    hsa-miR-501-5p hsa-let-7g* hsa-miR-1914* hsa-let-7a-2* hsa-miR-500a hsa-miR-609
    SwitchGear 3'UTR luciferase reporter plasmid: NFKB2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NFKB2
    Clone
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    OriGene ORF clones in mouse, rat for NFKB2
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    GenScript: all cDNA clones in your preferred vector (see all 3): NFKB2 (NM_002502)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKB2
    Addgene plasmids for NFKB2 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFKB2
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      QuantiFast Probe-based Assays in human, mouse, rat NFKB2

    Additional mRNA sequence: 

    AK098415.1 AK292654.1 BC002844.2 BT009769.1 NR_048560.1 S76638.1 U09609.2 X61498.1 
    X61499.1 

    11 DOTS entries:

    DT.91745508  DT.100787875  DT.100787878  DT.456108  DT.102827323  DT.121252623  DT.100787874  DT.121252632 
    DT.121252646  DT.75102361  DT.91745515 

    Selected AceView cDNA sequences (see all 151):

    AI076209 AI912172 CA432410 BM548928 BI258254 AW015196 BQ448336 BG119731 
    BQ654191 BU737985 BQ646520 BE410261 BM763392 BM833519 BE891295 BF876907 
    BQ961701 BU189580 BI769417 BX400217 BG764149 CA414621 BM452045 BM763876 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFKB2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
    SP1:                                                                                            -                                         -                     
    SP2:                                                                                                                                      -                     
    SP3:                                                                                            -                                                               
    SP4:                                                                                                                                                            
    SP5:                    -     -                                                                                                                                 

    ExUns: 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26
    SP1:        -                       -                                                   
    SP2:        -                       -                                                   
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for NFKB2

    Expression
    for NFKB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFKB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGGGGAG
    NFKB2 Expression
    About this image


    NFKB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Thymus (Hematopoietic System)
             Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    NFKB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    NFKB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73090
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFKB2 (see all 7): 
              NFKB Signaling Targets in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Cancer Drug Resistance in human mouse rat

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    Assay Products:     
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    Orthologs
    for NFKB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NFKB2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nfkb21 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 86.52(n)1
    91.89(a)1    		   19 (38.80 cM)5
    180341  NM_001177370.11  NP_001170841.11 
     463047375 
    chicken
    (Gallus gallus)    		 Aves NFKB21 nuclear factor of kappa light polypeptide gene enhancer more 67.31(n)
    67.42(a)    		   386574  NM_204413.1  NP_989744.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NFKB26
    		 nuclear factor of kappa light polypeptide gene enh...
    		 61(a)
    		 1 ↔ 1
    		 GL343196.1(414745-445347)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AB002629.12   -- 73.92(n)    AB002629.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa03b022 wufa03b02 73.28(n)   334761  BM102747.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dl3 immune response transcription factor 41(a)
    (best of 3)    		     --


    ENSEMBL Gene Tree for NFKB2 (if available)
    TreeFam Gene Tree for NFKB2 (if available)

    Paralogs
    for NFKB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for NFKB2 gene
    NFKB12  REL2  RELB2  RELA2  
    5 SIMAP similar genes for NFKB2 using alignment to 4 protein entries:     NFKB2_HUMAN (see all proteins):
    NFKB1    IkBa    RELA    REL    RELB

    Find genes that share paralogs with NFKB2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NFKB2
    PGOHUM00000234862 PGOHUM00000234993


    Genomic Variants
    for NFKB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for NFKB2 (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs603282911,2
    		C--104153288(+) AAATA-/AATA  
                GGCCG     		2 -- us2k11Minor allele frequency- AATA:0.00NA 2
    rs1176326721,2
    		F--104514602(+) TGGTTC/TCTCGA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1830091001,2
    		--104514606(+) TCCTCC/GAGTCC 1 -- us2k10--------
    rs10050441,2
    		C,F,A--104514700(+) GCAACC/ACACCC 1 -- us2k15Minor allele frequency- A:0.31WA NA EA 246
    rs1873269511,2
    		--104514716(+) ATTTTC/TTGAGA 1 -- us2k10--------
    rs127651351,2
    		C,F,H--104514990(+) AAActT/Cagggg 2 -- us2k18Minor allele frequency- C:0.03NS NA 900
    rs1158938211,2
    		F--104515010(+) CATCCT/CGGAGT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1411009121,2
    		--104515052(+) CCTTTC/GTAGCT 2 -- us2k10--------
    rs1177157971,2
    		C,F--104515123(+) TTCACC/TTCCTA 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1918621781,2
    		--104515124(+) TCACCC/TCCTAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NFKB2 (104153867 - 104162281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NFKB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv814n71CNV Loss21882294
    nsv895970CNV Loss21882294
    nsv525546CNV Loss19592680
    dgv815n71CNV Loss21882294
    nsv526665CNV Loss19592680

    Human Gene Mutation Database (HGMD): NFKB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFKB2
    DNA2.0 Custom Variant and Variant Library Synthesis for NFKB2

    Disorders / Diseases
    for NFKB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    		 OMIM gene information: 164012   
    OMIM disorders: 615577  
    UniProtKB/Swiss-Prot: NFKB2_HUMAN, Q00653
  • Note=A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL).
    Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant
  • Note=A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line.
    This rearrangement produces the p80HT gene which codes for a truncated 80 kDa protein (p80HT)
  • Note=In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal
    aberrations, such as internal deletions

    • 6 diseases for NFKB2:    
    About MalaCards
    immunodeficiency, common variable, 10    b-cell lymphomas    immunodeficiency, common variable, 3    splenic marginal zone lymphoma
    immunodeficiency, common variable, 1    legionellosis


    Find genes that share disorders with NFKB2           About GenesLikeMe

    8 Novoseek inferred disease relationships for NFKB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoid neoplasm 68.9 3 9150386 (1), 7651435 (1), 9523851 (1)
    lymphoma t-cell 57 1 7597296 (1)
    lymphoma 41.3 6 9150386 (1), 10713675 (1), 9021684 (1), 7597296 (1)
    lymphoma b-cell 37.4 1 7949142 (1)
    myeloma 25.2 1 17692804 (1)
    chromosomal aberrations 13.7 1 8108136 (1)
    tumors 5.04 6 7949142 (2), 8378093 (1), 1760839 (1)
    cancer 0 1 1760839 (1)

    Genatlas disease: NFKB2
    lymphoma,B cell,non Hodgkin,associated with breakpoint in t(10;14)(q24;q32) translocation

    Genetic Association Database (GAD): NFKB2
    Human Genome Epidemiology (HuGE) Navigator: NFKB2 (21 documents)
    Tumor Gene Database (TGDB): NFKB2

    Export disorders for NFKB2 gene to outside databases

    Publications
    for NFKB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for NFKB2 gene, integrated from 10 sources (see all 263):
    (articles sorted by number of sources associating them with NFKB2)

    1. Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65. (PubMed id 1876189)1, 2, 3 Schmid R.M.... Nabel G.J. (Nature 1991)
    2. Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies. (PubMed id 7949142)1, 2, 9 Migliazza A.... Neri A. (Blood 1994)
    3. Structural and functional characterization of the promoter regions of the NFKB2 gene. (PubMed id 7541912)1, 2, 9 Lombardi L.... Neri A. (Nucleic Acids Res. 1995)
    4. Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells. (PubMed id 8036016)1, 2, 9 Thakur S.... Rabson A.B. (Oncogene 1994)
    5. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. (PubMed id 1760839)1, 2, 9 Neri A.... Dalla-Favera R. (Cell 1991)
    6. Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene. (PubMed id 8360178)1, 2, 9 Potter D.A.... Sharp P.A. (J. Biol. Chem. 1993)
    7. The generation of nfkb2 p52: mechanism and efficiency. (PubMed id 10597218)1, 2, 9 Heusch M.... Greene W.C. (Oncogene 1999)
    8. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    9. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. (PubMed id 8453667)1, 2, 9 Bours V....Siebenlist U. (Cell 1993)
    10. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. (PubMed id 20448286)1, 4 Potter C....Isaacs J.D. (Ann. Rheum. Dis. 2010)

    External Searches for NFKB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NFKB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4791 HGNC: 7795 AceView: NFKB2 Ensembl:ENSG00000077150 euGenes: HUgn4791
    ECgene: NFKB2 Kegg: 4791 H-InvDB: NFKB2

    Other Databases showing NFKB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NFKB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFKB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFKB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nfkb2/

    Intellectual Property
    for NFKB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFKB2 gene:
    Search GeneIP for patents involving NFKB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NFKB2 gene

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    About This Section


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