 |
 | Services
| |
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Aliases &
Descriptions
for NFKB1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| DKFZp686C01211 2 | | EBP-1 2, 3 | | KBF1 1, 2 | | MGC54151 2 | | NF-kappa-B 2 | | NF-kappabeta 1, 2 | | NFKB-p105 2 | | NFKB-p50 1, 2 | | p105 1, 2 | | p50 1, 2 |
| | | Descriptions |
|---|
| DNA binding factor KBF1 2 | | DNA-binding factor KBF1 3 | | nuclear factor NF-kappa-B p50 subunit 2 | | nuclear factor kappa-B DNA binding subunit 2 | | nuclear factor kappa-B, subunit 1 2 | nuclear factor of kappa light polypeptide gene enhancer in
B-cells 1 2 |
|
| |
Search outside databases for aliases for NFKB1 genePrevious GC identifers: GC04P103821 GC04P103880 GC04P103779 |
Summaries
for NFKB1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NFKB1:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S
proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription
inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex.
NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli
such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral
products. Activated NFKB translocates into the nucleus and stimulates the expression of genes
involved in a wide variety of biological functions. Inappropriate activation of NFKB has been
associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to
inappropriate immune cell development or delayed cell growth. [provided by RefSeq]
UniProtKB/Swiss-Prot: NFKB1_HUMAN, P19838Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
types and is involved in many biological processed such as inflammation, immunity,
differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The
dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have
distinct preferences for different kappa-B sites that they can bind with distinguishable affinity
and specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
and subcellular compartmentalization as well as by interactions with other cofactors or
corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators.
The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional
activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic
retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational
processing. The proteasome-mediated process ensures the production of both p50 and p105 and
preserves their independent function, although processing of NFKB1/p105 also appears to occur
post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the
enhancer region of genes involved in immune response and acute phase reactions. In a complex with
MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by
proteasome-dependent degradation of NFKB1/p105Gene Wiki entry for NFKB1 |
Genomic Location
for NFKB1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the NFKB1 gene 
Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24NFKB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P103641:
(about GC identifiers)
Start:
|
103,641,518 bp from pter |
End:
|
103,757,507 bp from pter |
Size:
|
115,990 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins
for NFKB1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NFKB1_HUMAN, P19838 (See
protein sequence)Recommended Name: Nuclear factor NF-kappa-B p105 subunit Size: 968 amino acids; 105356 Da
Subunit: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex.
Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50
complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the
NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit
interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its
histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear
translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR;
the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8
and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50
interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit
interacts with NFKBID (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an
inactive form complexed to an inhibitor (I-kappa-B)
PDB structures from  and Proteopedia  :1MDI (3D)
1MDJ (3D)
1MDK (3D)
1NFI (3D)
1SVC (3D)
2DBF (3D)
2O61 (3D)
Secondary accessions: Q68D84 Q86V43 Q8N4X7 Q9NZC0Alternative splicing: 2 isoforms: P19838-1 P19838-2 Post-translational modifications:
While translation occurs, the particular unfolded structure after the GRR repeat promotes the
generation of p50 making it an acceptable substrate for the proteasome. This process is known as
cotranslational processing. The processed form is active and the unprocessed form acts as an
inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in
the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing1
Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to
TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for
BTRC/BTRCP-mediated proteolysis1
Polyubiquitination seems to allow p105 processing1
S-nitrosylation of Cys-61 affects DNA binding1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003989.2
ENSEMBL proteins: ENSP00000226574 ENSP00000378297
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NFKB1:  | Invitrogen Antibodies for NFKB1 |  | Millipore Mono- and Polyclonal Antibodies for the study of NFKB1 |  | Sigma-Aldrich Antibody Arrays and Antibodies for NFKB1 |  | R&D Systems Antibodies for NFKB1 |  | Cell Signaling Technology (CST) Antibodies for NFKB1 (NF-kB1) |  | Antibodies from Abcam (NFkB p105 / p50), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (NFKB1) |  | Novus Biologicals Antibodies for NFKB1 |
Assays for NFKB1: | Protein
Domains/
Families
for NFKB1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P19838
ProtoNet protein and cluster: P19838 4 Blocks protein families: IPB000451 NF-kappa-B/Rel/dorsal family IPB000488 Death domain IPB002909 Cell surface receptor IPT/TIG IPB011539 Rel homology
UniProtKB/Swiss-Prot: NFKB1_HUMAN, P19838Domain: The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of
DNA-binding, and transcription activationDomain: Glycine-rich region (GRR) appears to be a critical element in the generation of p50Similarity: Contains 7 ANK repeatsSimilarity: Contains 1 death domainSimilarity: Contains 1 RHD (Rel-like) domain | Gene Function
for NFKB1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Inhib.
RNA: | | Invitrogen RNAi Products for gene knock-down (NFKB1) | | | Millipore RNAi Products for the Analysis of NFKB1 Gene knock-down | | | Abnova Chimera RNAi Products for Gene knock-down (NFKB1) |
OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003998
 Applied Biosystems Silencer® siRNAs for NFKB1
Sigma-Aldrich siRNA for NFKB1
Sigma-Aldrich shRNA Panels and shRNA for NFKB1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_003998
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003998
untagged cDNA clone in CMV expression vector: NM_003998
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_003998
UniProtKB/Swiss-Prot: NFKB1_HUMAN, P19838Function: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell
types and is involved in many biological processed such as inflammation, immunity,
differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric
complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The
dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have
distinct preferences for different kappa-B sites that they can bind with distinguishable affinity
and specificity. Different dimer combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification
and subcellular compartmentalization as well as by interactions with other cofactors or
corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with
members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators,
subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the
nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators.
The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional
activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic
retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational
processing. The proteasome-mediated process ensures the production of both p50 and p105 and
preserves their independent function, although processing of NFKB1/p105 also appears to occur
post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the
enhancer region of genes involved in immune response and acute phase reactions. In a complex with
MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by
proteasome-dependent degradation of NFKB1/p105Induction: By phorbol ester and TNF-alphaGenatlas biochemistry entry for NFKB1:nuclear transcription factor of kappa light chain gene enhancer in B cells,1,(encoding the p105
precursor and the amino-terminal active p50 subunit),NF-kappa B/REL family15/17 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Nfkb1) (see all 17
):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for NFKB1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/64 Sigma-Aldrich "Your Favorite Gene" Pathways for NFKB1 (Your Favorite Gene powered by Ingenuity) (see all 64
)
Gene Network CentralTM Interacting Genes and Proteins Network for NFKB1
5/298 Interacting proteins for NFKB1 (ENSP000002265743 P198381, 2) via UniProtKB, MINT, and/or STRING (see all 298
)About this table
5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13
): About this table
|
Drugs & Compounds
for NFKB1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for NFKB1 |
 Compounds for NFKB1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Bay 11-7821 | Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation | [19542-67-7] | | Luteolin | Anti-inflammatory, antioxidant and free radical scavenger | [491-70-3] | | Caffeic acid phenethyl ester | Specific inhibitor of NF-kappaB activation | [104594-70-9] | | Bay 11-7085 | Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation | [196309-76-9] |
About this table
1  Novoseek chemical compound relationship for NFKB1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nitric oxide |
0.00 |
1 |
16964402 (1) |
About this table
|
Transcripts
for NFKB1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| Inhib.
RNA: | | Invitrogen RNAi Products for gene knock-down (NFKB1) | | | Millipore RNAi Products for the Analysis of NFKB1 Gene knock-down | | | Abnova Chimera RNAi Products for Gene knock-down (NFKB1) |
OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003998
Sigma-Aldrich siRNA for NFKB1
Sigma-Aldrich shRNA Panels and shRNA for NFKB1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_003998 REFSEQ mRNAs for NFKB1 gene: NM_003998.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003998
OriGene GFP tagged cDNA clone in CMV expression vector: NM_003998
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003998
untagged cDNA clone in CMV expression vector: NM_003998
Additional cDNA sequence: AK122850.1 AK291450.1 BC033210.1 BC051765.1 CR749522.1 M55643.1 M58603.1 13 DOTS entries: DT.91766168 DT.100723199 DT.100744892 DT.316891 DT.95258128 DT.100752227 DT.121254190 DT.101962127 DT.121254226 DT.316893 DT.40260693 DT.95288477 DT.40117323 24/221 AceView cDNA sequences (see all 221
):CB117382 CB150024 BQ962865 CB529452 BM931012 BE885945 CA421974 BQ687254 BQ677391 AW612589 N41629 H44239 CA313061 BQ879031 AA213622 H44238 BQ189331 AW511634 AK122850 BC033210 BI858055 BG120328 BQ023914 AI333374
 highest scoring ESTs for NFKB1:M58603 AA098834 AA134618 AA258085 AK122850 AW389922 AW801929 AW949720 BC033210 BC051765 Unigene Cluster for NFKB1: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Hs.654408 [show with all ESTs]Unigene Representative Sequence: NM_003998
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NFKB1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NFKB1
2 Ensembl transcripts including schematic representations: ENST00000226574
ENST00000394820
|
Expression
for NFKB1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NFKB1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NFKB1
1 / 2 / 3 5 probe-sets matching NFKB1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTTACAATCA
SOURCE GeneReport for Unigene cluster: Hs.654408
Expression variation in blood from EXPOLDB for NFKB1 |
Orthologs
for NFKB1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NFKB1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for NFKB1
ENSEMBL Gene Tree for NFKB1 | Paralogs
for NFKB1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NFKB1 gene
- REL2 NFKB22 RELB2 RELA2
|
SNPs/Variants
for NFKB1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NFKB1 (up to first 250kb)
|
Disorders & Mutations
for NFKB1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 164011
10 Novoseek disease relationships for NFKB1 gene
About this table
1 PharmGKB disease relationship for NFKB1 geneAbout this table
Human Gene Mutation Database: NFKB1
Genetic Association Database: NFKB1
Human Genome Epidemiology Navigator: NFKB1 (52 documents)
Tumor Gene Database: NFKB1
|
Medical News
for NFKB1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NFKB1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 44/1041 PubMed articles for NFKB1 gene (see all 1041
):- Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. (PubMed id 1992489)2, 3, 4 Meyer R....Scheidereit C. (1991)
- Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. (PubMed id 14613970)1, 3, 6 Karban A.S....Brant S.R. (2004)
- The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF- kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction. (PubMed id 8825636)1, 3, 4 Heron E.... van Loon A.P.G.M. (1995)
- The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. (PubMed id 2203531)1, 3, 4 Kieran M.... Israel A. (1990)
- Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. (PubMed id 12406554)1, 3, 6 Curran J.E....Griffiths L.R. (2002)
- Association of nuclear factor-kappaB in psoriatic arthritis. (PubMed id 16142871)1, 3, 6 Butt C....Rahman P. (2005)
- Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. (PubMed id 12839942)1, 3, 6 Landi S....Canzian F. (2003)
- Mutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients. (PubMed id 12203044)1, 3, 6 Wintermeyer P....Kruger R. (2002)
- Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production. (PubMed id 10970863)1, 3, 4 Lin L.... Greene W.C. (2000)
- Functional polymorphism in NFKB1 promoter is related to the risks of oral squamous cell carcinoma occurring on older male areca (betel) chewers. (PubMed id 16387424)3, 6 Lin S.C....Chang C.S. (2006)
- NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. (PubMed id 10469655)3, 4 Heissmeyer V.... Scheidereit C. (1999)
- Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome. (PubMed id 9529257)3, 4 Lin L.... Greene W.C. (1998)
- A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit. (PubMed id 8628291)3, 4 Lin L. and Ghosh S. (1996)
- Structure of the NF-kappa B p50 homodimer bound to DNA. (PubMed id 7830764)3, 4 Mueller C.W.... Harrison S.C. (1995)
- Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation. (PubMed id 9218802)1, 3 Watanabe N....Fujita T. (1997)
- Oxidative, multistep activation of the noncanonical NF-kappaB pathway via disulfide Bcl-3/p50 complex. (PubMed id 18796561)3 Cristofanon S....Diederich M. (2009)
- NF-kappaB transcription factor p50 critically regulates tissue factor in deep vein thrombosis. (PubMed id 19095643)3 Li Y.D....Geng J.G. (2009)
- Nuclear factor kappa B subunit p50 promotes melanoma angiogenesis by upregulating interleukin-6 expression. (PubMed id 18942706)3 Karst A.M....Li G. (2009)
- TNFalpha protects tissue resident stem cells from H2O2 induced apoptosis through a novel NF-small ka, CyrillicB p50/p50 homodimer mediated signaling pathway. (PubMed id 18433717)3 Droll L....Alt E. (2008)
- Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor necrosis factor-alpha. (PubMed id 17530443)3 Lee U.J....Choi Y.C. (2008)
- Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding. (PubMed id 18202112)3 Saha A....Smolka A.J. (2008)
- NF-kappaB p50 promotes tumor cell invasion through negative regulation of invasion suppressor gene CRMP-1 in human lung adenocarcinoma cells. (PubMed id 18782567)3 Gao M....Cheng A.L. (2008)
- NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. (PubMed id 16319923)3 Williams S.A....Greene W.C. (2006)
- Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis. (PubMed id 16519794)3 Hirohata S....Chiorazzi N. (2006)
- Prognostic significance of nuclear factor-kappaB p105/p50 in human melanoma and its role in cell migration. (PubMed id 16951147)3 Gao K....Li G. (2006)
- DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit. (PubMed id 15642694)3 Guan H....Ricciardi R.P. (2005)
- Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas. (PubMed id 16123212)3 Mathas S....Dorken B. (2005)
- Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB. (PubMed id 16285952)3 Shi X.Z....Sarna S.K. (2005)
- The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells. (PubMed id 14570916)3 Lim J.W....Kim K.H. (2004)
- Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages: involvement in cytokine synthesis. (PubMed id 15102766)4 Guizani-Tabbane L.... Dellagi K. (2004)
- Synergistic activation of the CMV promoter by NF-kappaB P50 and PKG. (PubMed id 15358208)3 He B. and Weber G.F. (2004)
- The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activation. (PubMed id 15543947)3 Tong X....Giardina C. (2004)
- Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma. (PubMed id 14678988)3 Thornburg N.J....Raab-Traub N. (2003)
- Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding. (PubMed id 12947093)3 Hou S....Ricciardi R.P. (2003)
- Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation. (PubMed id 12471036)4 Deng W.G....Wu K.K. (2003)
- Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. (PubMed id 11971907)3 Knuefermann P....Sivasubramanian N. (2002)
- Identification of a NF-kappaB site in the negative regulatory element (epsilon-NRAII) of human epsilon-globin gene and its binding protein NF-kappaB p50 in the nuclei of K562 cells. (PubMed id 11942414)3 Hou C.H....Qian R.L. (2002)
- Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations. (PubMed id 9556555)3 Na S.Y....Lee J.W. (1998)
- I(kappa)B(gamma) inhibits DNA binding of NF-kappaB p50 homodimers by interacting with residues that contact DNA. (PubMed id 8887676)3 Bell S....Hay R.T. (1996)
- Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization. (PubMed id 8423996)3 Mathew S....Chaganti R.S. (1993)
- The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor. (PubMed id 1518839)3 LeClair K.P....Sharp P.A. (1992)
- NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit. (PubMed id 2050119)3 Urban M.B....Baeuerle P.A. (1991)
- Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. (PubMed id 8849348)1 Handel M.L....Gravallese E.M. (1995)
- The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation. (PubMed id 1740105)1 Ten R.M....Israel A. (1992)
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