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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFKB1 Gene

protein-coding   GIFtS: 73
GCID: GC04P103422

Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells
11 2 3
     NFKB-p502
EBP-12 3     NFkappaB2
DNA-Binding Factor KBF12 3     DNA Binding Factor KBF12
KBF12     Nuclear Factor Kappa-B DNA Binding Subunit2
NF-kB12     Nuclear Factor NF-Kappa-B P105 Subunit2
NF-kappa-B2     Nuclear Factor NF-Kappa-B P50 Subunit2
NF-kappaB2     p1052
NF-kappabeta2     p502
NFKB-p1052     

External Ids:    HGNC: 77941   Entrez Gene: 47902   Ensembl: ENSG000001093207   OMIM: 1640115   UniProtKB: P198383   

Export aliases for NFKB1 gene to outside databases

Previous GC identifers: GC04P103821 GC04P103880 GC04P103779 GC04P103641 GC04P099158


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFKB1 Gene:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a
50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a
DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated
by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation,
and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of
genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated
with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell
development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for NFKB1 Gene: 
NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) is a protein-coding gene. Diseases associated with NFKB1 include limb-girdle muscular dystrophy type 2h, and cascade stomach, and among its related super-pathways are DR3 Signaling and RANK Signaling in Osteoclasts. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is REL.

UniProtKB/Swiss-Prot: NFKB1_HUMAN, P19838
Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of
a series of signal transduction events that are initiated by a vast array of stimuli related to many biological
processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B
is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,
NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers
bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for
different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer
combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various
mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions
with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state
complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently
degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B
heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is
a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears
to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of
p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105
and preserves their independent function, although processing of NFKB1/p105 also appears to occur
post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region
of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses
MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105

summary for NFKB1 Gene:
NF-kappaB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types.
It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in
regulating the immune response to infection. In unstimulated cells NF-kappaB dimers are sequestered
inactively in the cytoplasm by a protein complex called inhibitor of kappa B (IkappaB). IkappaB inactivates
NF-kappaB by masking the nuclear localization signals (NLS). Activation of NF-kappaB occurs via degradation
of IkappaB, a process that is initiated by its phosphorylation by IkappaB kinase (IKK). Phosphorylated IvB
becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation also results in IkappaB
ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus and regulate gene
expression. NF-kappaB turns on expression of IkappaB forming a negative feedback loop.

Gene Wiki entry for NFKB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFKB1 gene promoter:
         Oct-B1   RORalpha1   Max1   TBP   POU2F1   oct-B3   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NFKB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NFKB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFKB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

NFKB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFKB1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P103422:  view genomic region     (about GC identifiers)

Start:
103,422,486 bp from pter      End:
103,538,459 bp from pter
Size:
115,974 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NFKB1_HUMAN, P19838 (See protein sequence)
Recommended Name: Nuclear factor NF-kappa-B p105 subunit  
Size: 968 amino acids; 105356 Da
Subunit: Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer;
component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the
NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3.
Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate
NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this
interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts
with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and
TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE.
NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity).
Directly interacts with MEN1. Interacts with HIF1AN
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form
complexed to an inhibitor (I-kappa-B)
6/8 PDB 3D structures from and Proteopedia for NFKB1 (see all 8):
1MDI (3D)        1MDJ (3D)        1MDK (3D)        1NFI (3D)        1SVC (3D)        2DBF (3D)    
Secondary accessions: A8K5Y5 B3KVE8 Q68D84 Q86V43 Q8N4X7 Q9NZC0
Alternative splicing: 3 isoforms:  P19838-1   P19838-2   P19838-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFKB1: NX_P19838

Explore proteomics data for NFKB1 at MOPED 

Post-translational modifications:

  • UniProtKB: While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50
    making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The
    processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form
    cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of
    the GRR repeat precludes processing
  • UniProtKB: Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha
    stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis
  • UniProtKB: Polyubiquitination seems to allow p105 processing
  • UniProtKB: S-nitrosylation of Cys-61 affects DNA binding
  • UniProtKB: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It
    may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19838

  • NFKB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NFKB1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001158884.1  NP_003989.2  

    ENSEMBL proteins: 
     ENSP00000226574   ENSP00000378297   ENSP00000420904   ENSP00000426147   ENSP00000424790  
     ENSP00000423877   ENSP00000469340   ENSP00000424815  
    Reactome Protein details: P19838
    Human Recombinant Protein Products for NFKB1: 
    EMD Millipore Purified and/or Recombinant NFKB1 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for NFKB1
    OriGene Purified Protein for NFKB1
    OriGene Protein Over-expression Lysate for NFKB1
    OriGene MassSpec for NFKB1 
    OriGene Custom Protein Services for NFKB1
    GenScript Custom Purified and Recombinant Proteins Services for NFKB1
    Novus Biologicals NFKB1 Proteins
    Novus Biologicals NFKB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    NFKB1 for ontologies           About GeneDecksing



    NFKB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NFKB1
    R&D Systems Antibodies for NFKB1
    Cell Signaling Technology (CST) Antibodies for NFKB1  (NFkB-p105)
    OriGene Antibodies for NFKB1
    OriGene Custom Antibody Services for NFKB1
    GenScript Custom Superior Antibodies Services for NFKB1
    Novus Biologicals NFKB1 Antibodies
    Abcam antibodies for NFKB1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for NFKB1
    LSBio Antibodies in human, mouse, rat for NFKB1 

    Assay Products for NFKB1: 
    EMD Millipore Kits and Assays for the Analysis of NFKB1
    OriGene Custom Assay Services for NFKB1
    R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for NFKB1         (see all)
    GenScript Custom Assay Services for NFKB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    5/10 InterPro protein domains (see all 10):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR011029 DEATH-like_dom
     IPR002909 IPT_TIG_rcpt
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P19838

    ProtoNet protein and cluster: P19838

    4 Blocks protein domains:
    IPB000451 NF-kappa-B/Rel/dorsal family
    IPB000488 Death domain
    IPB002909 Cell surface receptor IPT/TIG
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: NFKB1_HUMAN, P19838
    Domain: The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and
    transcription activation
    Domain: Glycine-rich region (GRR) appears to be a critical element in the generation of p50
    Similarity: Contains 7 ANK repeats
    Similarity: Contains 1 death domain
    Similarity: Contains 1 RHD (Rel-like) domain


    NFKB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFKB1_HUMAN, P19838
    Function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of
    a series of signal transduction events that are initiated by a vast array of stimuli related to many biological
    processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B
    is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,
    NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers
    bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for
    different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer
    combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various
    mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions
    with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state
    complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway,
    I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently
    degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B
    heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is
    a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears
    to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of
    p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105
    and preserves their independent function, although processing of NFKB1/p105 also appears to occur
    post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region
    of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses
    MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105
    Induction: By phorbol ester and TNF

         Genatlas biochemistry entry for NFKB1:
    nuclear transcription factor of kappa light chain gene enhancer in B cells,1,(encoding the p105 precursor and the
    amino-terminal active p50 subunit),NF-kappa B/REL family

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding IDA17426251
    GO:0000976transcription regulatory region sequence-specific DNA binding IDA18718911
    GO:0001071nucleic acid binding transcription factor activity IDA17426251
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
         
    NFKB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NFKB1:
     Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         15/17 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nfkb1) (see all 17):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  nervous system  normal 

    NFKB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NFKB1: Nfkb1tm1Brv Nfkb1tm1Bal

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NFKB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFKB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFKB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFKB1 

    10/1076 SABiosciences Target genes for NFKB1 (see all 1076):
    A3GALT2 AARS2 ABAT ABCA4 ABCB6 ABR ACAD11 ACSM2B ACTR3B ADD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NFKB1:
    hsa-let-7a (MIRT004830), hsa-mir-15a (MIRT004829), hsa-mir-146b-5p (MIRT004530), hsa-mir-146a (MIRT004459), hsa-mir-9 (MIRT003193)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFKB1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NFKB1 (see all 22):
    hsa-miR-548j hsa-miR-4291 hsa-miR-548i hsa-miR-605 hsa-miR-340 hsa-miR-548l hsa-miR-508-3p hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidNFKB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NFKB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFKB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFKB1
    Sirion Biotech Customized adenovirus for overexpression of NFKB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NFKB1 (see all 11)
    OriGene ORF clones in mouse, rat for NFKB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFKB1 (NM_003998)
    Sino Biological Human cDNA Clone for NFKB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFKB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFKB1
    Sirion Biotech Customized lentivirus for stable overexpression of NFKB1 
                         Customized lentivirus expression plasmids for stable overexpression of NFKB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFKB1
    Search LifeMap BioReagents cell lines for NFKB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFKB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NFKB1 About   (see all 176)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    2BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    3B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.35
    4Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    5Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/49 EMD Millipore Pathways for NFKB1 (see all 49)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Development TGF-beta receptor signaling
    Immune response IL-1 signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/7 R&D Systems Pathways for NFKB1 (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/100 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFKB1 (see all 100)
        Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    NF-kappaB Activation by Viruses
    BMP Pathway
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for NFKB1
        NF-kappaB Signaling

    4 Tocris Bioscience Pathways for NFKB1
        Akt Pathway
    Apoptosis Pathway
    Toll-like Receptor Pathway
    NF-kappaB Pathway

    5/57 GeneGo (Thomson Reuters) Pathways for NFKB1 (see all 57)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway

    5/56 BioSystems Pathways for NFKB1 (see all 56)
        MAPK signaling pathway
    EBV LMP1 signaling
    MicroRNAs in cardiomyocyte hypertrophy
    Apoptosis
    Myometrial Relaxation and Contraction Pathways


    5/44        Reactome Pathways for NFKB1 (see all 44)
        Toll Like Receptor 2 (TLR2) Cascade
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Toll Like Receptor TLR6:TLR2 Cascade
    FCERI mediated NF-kB activation
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex

    3 PharmGKB Pathways for NFKB1
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/46         Kegg Pathways  (Kegg details for NFKB1) (see all 46):
        MAPK signaling pathway
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    HIF-1 signaling pathway
    PI3K-Akt signaling pathway


    NFKB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFKB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/426 Interacting proteins for NFKB1 (P198381, 2, 3 ENSP000002265744) via UniProtKB, MINT, STRING, and/or I2D (see all 426)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042061, 2, 3, ENSP000003842734EBI-300010,EBI-73886 MINT-47911 MINT-6178467 MINT-48923 MINT-47891 MINT-6178544 MINT-48559 MINT-6178520 MINT-48686 I2D: score=10 STRING: ENSP00000384273
    NFKB2Q006532, 3, ENSP000001894444MINT-48553 MINT-6178467 MINT-6178504 MINT-47910 MINT-48724 MINT-6178544 MINT-48674 MINT-47890 MINT-48585 MINT-6178520 MINT-47923 MINT-6178488 I2D: score=8 STRING: ENSP00000189444
    RELBQ012012, 3, ENSP000002214524MINT-48017 MINT-48562 MINT-6178544 MINT-48996 MINT-6178520 MINT-47912 MINT-6178488 MINT-48690 I2D: score=7 STRING: ENSP00000221452
    ENSG00000183311P074372, 3MINT-48672 MINT-48551 I2D: score=1 
    ENSG00000224156P074372, 3MINT-48672 MINT-48551 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP19881551
    GO:0001818negative regulation of cytokine production IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    NFKB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NFKB1 for compounds           About GeneDecksing

    EMD Millipore small molecules for NFKB1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NFKB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SC 514IKKbeta inhibitor; attenuates NF-kappaB-induced gene expression[354812-17-2]
    Ro 106-9920Inhibitor of NF-kappaB activation[62645-28-7]
    IMD 0354Inhibitor of IKKbeta[978-62-1]
    CelastrolInhibits TNF-alpha-induced NF-kappaB activation[34157-83-0]
    Bay 11-7085Irreversible inhibitor of TNF-alpha-induced IkappaBalpha phosphorylation[196309-76-9]

    3 DrugBank Compounds for NFKB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Triflusal-- --targetantagonist15678110 18317243 19465361 17194886
    Pranlukast-- 103177-37-3targetother/unknown12801315 12801316
    Thalidomidealpha-phthalimidoglutarimide (see all 5)50-35-1targetantagonist15723633 11752352

    2 Novoseek inferred chemical compound relationships for NFKB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etoposide 3.68 1 16778171 (1)
    nitric oxide 0 1 16964402 (1)

    Search CenterWatch for drugs/clinical trials and news about NFKB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFKB1 gene (2 alternative transcripts): 
    NM_001165412.1  NM_003998.3  

    Unigene Cluster for NFKB1:

    Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    Hs.618430  [show with all ESTs]
    Unigene Representative Sequence: NM_003998
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226574(uc011cep.2 uc011ceq.2 uc011cer.2) ENST00000394820
    ENST00000511926 ENST00000507079 ENST00000505458 ENST00000509165 ENST00000513803
    ENST00000502367 ENST00000510638 ENST00000600343 ENST00000508584 ENST00000504044

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK122850.1 AK291450.1 BC033210.1 BC051765.1 CR749522.1 M55643.1 M58603.1 

    14 DOTS entries:

    DT.91766168  DT.100723199  DT.100744892  DT.95258128  DT.100752227  DT.121254190  DT.101962127  DT.121254226 
    DT.316891  DT.316893  DT.40260693  DT.95288477  DT.315662  DT.40117323 

    24/221 AceView cDNA sequences (see all 221):

    BI858055 AW612589 CB529452 BC033210 H49196 CK299474 AW511634 NM_003998 
    CF541044 T86858 BM931012 CF137176 AW172686 BG282944 BG120328 AL118961 
    D16976 BQ023914 CB117382 BQ677391 BQ710652 BQ962865 N41629 H44238 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NFKB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                          -                             -                             -                                                                     
    SP2:                          -                             -                             -                                                                     
    SP3:                                                                                      -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b · 24c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for NFKB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFKB1 expression in normal human tissues (normalized intensities)      NFKB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTACAATCA
    NFKB1 Expression
    About this image


    NFKB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Hair (Integumentary System)    fully expand to see all 8 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
             mouse/organ system/integumental system   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             brain/hindbrain   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/urethra of male/pelvic urethra of male   
     
     Thymus (Hematopoietic System)
             Thymus

    See NFKB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFKB1

    SOURCE GeneReport for Unigene cluster: Hs.618430
        SABiosciences Expression via Pathway-Focused PCR Arrays including NFKB1 (see all 46): 
              Lung Cancer in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NFKB1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfkb11 , 5 nuclear factor of kappa light polypeptide gene enhancer more1, 5 84.46(n)1
    87.75(a)1
      3 (62.82 cM)5
    180331  NM_008689.21  NP_032715.21 
     1355846555 
    chicken
    (Gallus gallus)
    Aves NFKB11 nuclear factor of kappa light polypeptide gene enhancer more 71.66(n)
    74.32(a)
      396033  NM_205134.1  NP_990465.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.114352 Transcribed sequence with weak similarity to protein more 73.34(n)    137695842 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.109432 Oncorhynchus mykiss transcribed sequence with weak more 74.53(n)    BX880658.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dl3
    Rel1
    immune response transcription factor3
    Relish1
    41(a)
    (best of 2)3
    41.86(n)1
    30.31(a)1
      410871  NM_057746.31  NP_477094.11 


    ENSEMBL Gene Tree for NFKB1 (if available)
    TreeFam Gene Tree for NFKB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFKB1 gene
    REL2  NFKB22  RELB2  RELA2  
    3 SIMAP similar genes for NFKB1 using alignment to 5 protein entries:     NFKB1_HUMAN (see all proteins):
    NFKB2    RELA    NFKBIA

    NFKB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2220 SNPs in NFKB1 are shown (see all 2220)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs780231091,2
    C,F--103420609(+) TATGCC/GTGCTC 2 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs119400171,2
    C,F,H--103420759(+) ATTTAT/CCTATC 2 -- us2k1 tfbs310Minor allele frequency- C:0.15NA EA WA 610
    rs68197751,2
    C--103420838(+) tccctC/Tcctct 2 -- us2k1 tfbs3 trp30--------
    rs106475501,2
    C--103420851(+) TCTCTCTCT/-  
            
    TTCTT
    2 -- us2k1 tfbs3 trp31Minor allele frequency- -:0.50CSA 2
    rs623285391,2
    C,F--103420851(+) CCCTCC/TCTCTC 2 -- us2k12Minor allele frequency- T:0.50WA NA 4
    rs666418611,2
    C--103420852(+) CTCCC-/CTC   
      T
    /TCTC
    TCTCT
    2 -- us2k11NA 2
    rs119400651,2
    C,H--103420860(+) TCTCTT/CTCTTT 2 -- us2k1 trp34Minor allele frequency- C:0.19NA WA EA 360
    rs1842561501,2
    --103420916(+) GCGCAA/GTCTTG 2 -- us2k10--------
    rs119444431,2
    C,F,H--103421018(+) GGCTAA/GTTTTT 2 -- us2k12Minor allele frequency- G:0.33NA 6
    rs1896083811,2
    --103421131(+) TTACAA/GGTGTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NFKB1 (103422486 - 103538459 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NFKB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728077CNV Deletion23290073
    nsv4442CNV Insertion18451855
    esv27559CNV Loss19812545
    nsv830020CNV Loss17160897


    Human Gene Mutation Database (HGMD): NFKB1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NFKB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164011    OMIM disorders: --

    20/214 diseases for NFKB1 (see all 214):    About MalaCards
    limb-girdle muscular dystrophy type 2h    cascade stomach    aneurysmal bone cysts    hepatitis d
    primary mediastinal large b-cell lymphoma    crimean-congo hemorrhagic fever    prolymphocytic leukemia    htlv-1 associated myelopathy/tropical spastic paraparesis
    t-cell prolymphocytic leukemia    htlv-1 associated myelopathy    fibrodysplasia ossificans progressiva    retinal ischemia
    central nervous system disease    hereditary breast cancer    migraine without aura    nervous system disease
    limb-girdle muscular dystrophy    middle ear cholesteatoma    crohn's disease    cerebral hemorrhage


    NFKB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for NFKB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 36.5 4 16778171 (3)
    colitis ulcerative 35.3 4 14613970 (2), 16804398 (1), 17852842 (1)
    necrosis 32.8 3 19692203 (1), 12839942 (1), 16964402 (1)
    tumors 23.2 8 17725175 (2), 16740744 (1), 19692203 (1), 12839942 (1) (see all 5)
    inflammation 21.9 1 18315734 (1)
    leukemia 19.9 2 1612589 (1), 9619918 (1)
    colorectal cancer 6.87 4 17852842 (2), 12839942 (1)
    vasculitis 1.79 1 15262741 (1)
    breast cancer 0 4 12406554 (3), 17487680 (1)
    diabetes mellitus 0 1 17318773 (1)

    Genetic Association Database (GAD): NFKB1
    Human Genome Epidemiology (HuGE) Navigator: NFKB1 (125 documents)
    Tumor Gene Database (TGDB): NFKB1

    Export disorders for NFKB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFKB1 gene, integrated from 9 sources (see all 2091):
    (articles sorted by number of sources associating them with NFKB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. (PubMed id 1992489)1, 2, 3 Meyer R....Scheidereit C. (1991)
    2. HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients. (PubMed id 17318773)1, 4, 9 Katarina K....Marie C. (2007)
    3. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. (PubMed id 14613970)1, 4, 9 Karban A.S....Brant S.R. (2004)
    4. Insertion/deletion polymorphism in the promoter regio n of NFKB1 gene increases susceptibility for superficial bladder cancer in Chin ese. (PubMed id 19778281)1, 4, 9 Tang T....Li J. (2010)
    5. A functional promoter polymorphism in NFKB1 increases susceptibility to endometriosis. (PubMed id 20218898)1, 4, 9 Zhou B....Zhang L. (2010)
    6. Insertion/deletion polymorphism in the promoter of NFKB1 as a potential molecular marker for the risk of recurrence in superficial bladder cancer. (PubMed id 17725175)1, 4, 9 Riemann K....Siffert W. (2007)
    7. The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF- kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction. (PubMed id 8825636)1, 2, 9 Heron E.... van Loon A.P.G.M. (1995)
    8. The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product. (PubMed id 2203531)1, 2, 9 Kieran M.... Israel A. (1990)
    9. Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes. (PubMed id 16804398)1, 4, 9 Glas J....Folwaczny C. (2006)
    10. A functional insertion/deletion polymorphism in the promoter region of the NFKB1 gene increases susceptibility for prostate cancer. (PubMed id 19446741)1, 4, 9 Zhang P....Li H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4790 HGNC: 7794 AceView: NFKB1 Ensembl:ENSG00000109320 euGenes: HUgn4790
    ECgene: NFKB1 Kegg: 4790 H-InvDB: NFKB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFKB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFKB1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nfkb1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFKB1 gene:
    Search GeneIP for patents involving NFKB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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