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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFIL3 Gene

protein-coding   GIFtS: 50
GCID: GC09M094171

nuclear factor, interleukin 3 regulated


(Previous symbol: IL3BP1)
 Explore 12 diseases affiliated with
NFIL3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NFIL3    

Aliases
for NFIL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Factor, Interleukin 3 Regulated1 2     Interleukin-3-Binding Protein 12 3
E4BP41 2 3 5     Transcriptional Activator NF-IL3A2 3
IL3BP11 2 3     E4 Promoter-Binding Protein 42 3
NFIL3A1 2 5     Nuclear Factor Interleukin 3 Regulated Protein2
NF-IL3A1 2     Nuclear Factor Interleukin-3-Regulated Protein2
Interleukin-3 Promoter Transcriptional Activator2 3     

External Ids:    HGNC: 77871   Entrez Gene: 47832   Ensembl: ENSG000001650307   OMIM: 6053275   UniProtKB: Q166493   

Export aliases for NFIL3 gene to outside databases

Previous GC identifers: GC09M085011 GC09M085899 GC09M087470 GC09M089512 GC09M091250 GC09M093211 GC09M063851


Summaries
for NFIL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NFIL3:
Expression of interleukin-3 (IL3; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast
cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3,
that bind to regulatory regions of the gene, usually upstream of the transcription start site (Zhang et al., 1995
(PubMed 7565758)).(supplied by OMIM, Feb 2009)

UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
Function: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a
sequence present in many cellular and viral promoters. Represses transcription from promoters with activating
transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses
transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the
promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same
consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian
clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core
clock (By similarity). Protects pro-B cells from programmed cell death (By similarity)

Gene Wiki entry for NFIL3


Genomic Views
for NFIL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFIL3 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   CREB   COUP-TF   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NFIL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NFIL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFIL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

NFIL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIL3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M094171:  view genomic region     (about GC identifiers)

Start:
 94,171,327 bp from pter      End:
 94,186,144 bp from pter
Size:
 14,818 bases      Orientation:
 minus strand

Proteins
for NFIL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649 (See protein sequence)
Recommended Name: Nuclear factor interleukin-3-regulated protein  
Size: 462 amino acids; 51472 Da
Subunit: Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2R9Y8 Q14211 Q6FGQ8 Q96HS0

Explore the universe of human proteins at neXtProt for NFIL3: NX_Q16649

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16649

    • NFIL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005375.2  
    ENSEMBL proteins: 
     ENSP00000364876   ENSP00000297689  

    Human Recombinant Protein Products: 
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    Novus Biologicals NFIL3 Protein
    Novus Biologicals NFIL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NFIL3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--


    NFIL3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NFIL3

    Protein Domains /
    Families
    for NFIL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NFIL3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004827 bZIP
     IPR016743 TF_bZIP_E4BP4
     IPR010533 Vert_IL3-reg_TF

    Graphical View of Domain Structure for InterPro Entry Q16649

    ProtoNet protein and cluster: Q16649

    UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
    Similarity: Belongs to the bZIP family. NFIL3 subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Function
    for NFIL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
    Function: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a
    sequence present in many cellular and viral promoters. Represses transcription from promoters with activating
    transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses
    transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the
    promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same
    consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian
    clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core
    clock (By similarity). Protects pro-B cells from programmed cell death (By similarity)
    Induction: Up-regulated by PHA or TPA

    10/332 SABiosciences Target genes for NFIL3 (see all 332):
    ABCA12 ABCC13 ABCC4 ACTR3B ADAM23 ADAMDEC1 ADM2 AHSG AKAP3 AMPD1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFIL3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIL3:
    hsa-miR-203 hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NFIL3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFIL3 (see all 7)
    OriGene shRNA RFP: NFIL3
    OriGene siRNA: NFIL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFIL3

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFIL3 (see all 3)
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA--
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding TAS1620116
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7565758


    NFIL3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NFIL3:
     Increased cell number in G1, a 

    Animal Models:
         Mouse knock-outs for NFIL3: Nfil3tm1Pbro Nfil3tm1Look Nfil3tm1.1Brad
         6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Nfil3):
     cellular  digestive/alimentary  growth/size  hematopoietic system  immune system 
     no phenotypic analysis 

    NFIL3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NFIL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFIL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/17 Interacting proteins for NFIL3 (Q166492, 3 ENSP000002976894) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CREB3O438893, ENSP000003421364I2D: score=3 STRING: ENSP00000342136
    DR1Q016583, ENSP000003592904I2D: score=3 STRING: ENSP00000359290
    CREMQ030603I2D: score=2 
    AMOTL2Q9Y2J43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS7565758
    GO:0006955immune response TAS7565758


    NFIL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NFIL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFIL3
    Search CenterWatch for drugs/clinical trials and news about NFIL3 

    Transcripts
    for NFIL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NFIL3 gene: 
    NM_005384.2  

    Unigene Cluster for NFIL3:

    Nuclear factor, interleukin 3 regulated
    Hs.79334  [show with all ESTs]
    Unigene Representative Sequence: NM_005384
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375724(uc004arh.3) ENST00000297689

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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIL3:
    hsa-miR-203 hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NFIL3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFIL3 (see all 7)
    OriGene shRNA RFP: NFIL3
    OriGene siRNA: NFIL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFIL3
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFIL3

    Additional cDNA sequence: 

    AK313970.1 BC008197.1 CR542049.1 HM204564.1 S79880.1 U26173.1 X64318.1 

    5 DOTS entries:

    DT.314723  DT.92429461  DT.100755497  DT.92429471  DT.95372988 

    24/140 AceView cDNA sequences (see all 140):

    BF439788 CR608714 AI167884 BQ937243 BM699289 CR614563 CA447529 AA370768 
    CB243154 BM760317 BU168451 BM824187 BU619762 CR599259 BC008197 BQ686697 
    CA487715 BG112950 AI039170 BQ719872 AW768857 BX417939 BQ575820 BQ003179 

    GeneLoc Exon Structure


    Expression
    for NFIL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFIL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGAAGGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NFIL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NFIL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFIL3

    SOURCE GeneReport for Unigene cluster: Hs.79334

    UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
    Tissue specificity: Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow
    and muscle

        SABiosciences Expression via Pathway-Focused PCR Array including NFIL3: 
              Circadian Rhythms in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for NFIL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NFIL3 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nfil31 , 5 nuclear factor, interleukin 3, regulated1, 5 79.54(n)1
    84.6(a)1    		   13 (27.68 cM)5
    180301  NM_017373.31  NP_059069.11 
     529672095 
    chicken
    (Gallus gallus)    		 Aves NFIL31 nuclear factor, interleukin 3 regulated 81.51(n)
    83.84(a)    		   395326  NM_204618.1  NP_989949.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NFIL36
    		 --
    		 81(a)
    		 1 ↔ 1
    		 2(31881526-31882914)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk63e102 Danio rerio cDNA clone IMAGE4786389, partial cds 73.59(n)    BC060943.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta vri6
    		 vrille
    		 11(a)
    		 1 ↔ 1
    		 2L(5299647-5310996)
    worm
    (Caenorhabditis elegans)    		 Secernentea atf-26
    		 ATF (cAMP-dependent transciption factor) family me...
    		 18(a)
    		 1 ↔ 1
    		 II(8751933-8753886)


    ENSEMBL Gene Tree for NFIL3 (if available)
    TreeFam Gene Tree for NFIL3 (if available) 

    Paralogs
    for NFIL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFIL3 gene

    NFIL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NFIL3
    PGOHUM00000234482


    Genomic Variants
    for NFIL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/269 NCBI SNPs in NFIL3 are shown (see all 269)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs7742301,2
    		C,--94170871(+) AGATTG/ATTATA 1 -- int14Minor allele frequency- A:0.06NA EA 244
    rs1841169041,2
    		--94170991(+) ATCCAC/TGTGTC 1 -- int10--------
    rs1393277391,2
    		C,--94171104(+) TAATA-/TAAAG 
                TAATT     		1 -- int10--------
    rs1880458661,2
    		--94171381(+) TATAAC/TAGAAC 1 -- ut310--------
    rs1142060361,2
    		--94171438(+) ACTATA/GCACAG 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs1924809851,2
    		C,--94171592(+) ATGACA/TTCTTT 1 -- ut310--------
    rs37478401,2
    		C,F,H,--94171628(+) GTAATT/CTACCC 2 /* syn1 ese310Minor allele frequency- C:0.00EA NS NA 6680
    rs1850398421,2
    		C,--94171661(+) TGTGTA/GGCTAT 2 A syn10--------
    rs1895601021,2
    		C,--94171666(+) GGCTAA/TAAGTC 2 I L mis10--------
    rs1506120411,2
    		C,F,--94171696(+) TGCAGA/GTAAGT 2 P S mis11Minor allele frequency- G:0.00NA 4550

    HapMap Linkage Disequilibrium report for NFIL3 (94171327 - 94186144 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NFIL3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFIL3
    DNA2.0 Custom Variant and Variant Library Synthesis for NFIL3

    Disorders / Diseases
    for NFIL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NFIL3 for disorders           About GeneDecksing

    OMIM gene information: 605327    OMIM disorders: --

    12 diseases for NFIL3:    About MalaCards
    attention deficit hyperactivity disorder    hereditary sensory neuropathy    autism spectrum disorder    bipolar i disorder
    schizoaffective disorder    hepatitis b    multiple myeloma    neuropathy
    myeloma    hepatitis    schizophrenia    thyroiditis

    1 Novoseek disease relationship for NFIL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 14.9 2 10074173 (1), 10627534 (1)

    Human Genome Epidemiology (HuGE) Navigator: NFIL3 (7 documents)

    Export disorders for NFIL3 gene to outside databases

    Publications
    for NFIL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFIL3 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with NFIL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. (PubMed id 7565758)1, 2, 3, 9 Zhang W.... Nimer S.D. (1995)
    2. Transcriptional repression by a novel member of the bZIP family of transcription factors. (PubMed id 1620116)1, 2, 3 Cowell I.G....Hurst H.C. (1992)
    3. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. (PubMed id 8836190)1, 2, 9 Cowell I.G. and Hurst H.C. (1996)
    4. Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis. (PubMed id 10942106)1, 2 Hulme D.J.... Nicholson G.A. (2000)
    5. Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells. (PubMed id 18829486)1, 9 Silvestris F....Dammacco F. (2008)
    6. Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells. (PubMed id 16630563)1, 9 Priceman S.J....Medh R.D. (2006)
    7. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. (PubMed id 9122243)1, 9 Ikushima S....Look A.T. (1997)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    10. Systematic analysis of circadian genes in a populatio n-based sample reveals association of TIMELESS with depression and sleep distur bance. (PubMed id 20174623)1 Utge S.J....Paunio T. (2010)

    External Searches for NFIL3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NFIL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4783 HGNC: 7787 AceView: NFIL3 Ensembl:ENSG00000165030 euGenes: HUgn4783
    ECgene: NFIL3 H-InvDB: NFIL3

    Other Databases showing NFIL3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NFIL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFIL3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NFIL3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFIL3 gene:
    Search GeneIP for patents involving NFIL3

    GeneCards and IP:
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