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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFIL3 Gene

protein-coding   GIFtS: 52
GCID: GC09M094171

Nuclear Factor, Interleukin 3 Regulated


(Previous symbol: IL3BP1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Factor, Interleukin 3 Regulated1 2     E4 Promoter-Binding Protein 42 3
IL3BP11 2 3     NFIL3A2 5
E4BP42 3 5     NF-IL3A2
Interleukin-3 Promoter Transcriptional Activator2 3     Nuclear Factor Interleukin 3 Regulated Protein2
Interleukin-3-Binding Protein 12 3     Nuclear Factor Interleukin-3-Regulated Protein2
Transcriptional Activator NF-IL3A2 3     

External Ids:    HGNC: 77871   Entrez Gene: 47832   Ensembl: ENSG000001650307   OMIM: 6053275   UniProtKB: Q166493   

Export aliases for NFIL3 gene to outside databases

Previous GC identifers: GC09M085011 GC09M085899 GC09M087470 GC09M089512 GC09M091250 GC09M093211 GC09M063851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFIL3 Gene:
Expression of interleukin-3 (IL3; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and
mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as
NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site (Zhang et
al., 1995 (PubMed 7565758)).(supplied by OMIM, Feb 2009)

GeneCards Summary for NFIL3 Gene: 
NFIL3 (nuclear factor, interleukin 3 regulated) is a protein-coding gene. Diseases associated with NFIL3 include bipolar i disorder, and hereditary sensory neuropathy. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
Function: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3',
a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating
transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses
transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on
the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for
the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the
circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the
cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity)

Gene Wiki entry for NFIL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFIL3 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   CREB   COUP-TF   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFIL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NFIL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFIL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

NFIL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIL3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M094171:  view genomic region     (about GC identifiers)

Start:
94,171,327 bp from pter      End:
94,186,144 bp from pter
Size:
14,818 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649 (See protein sequence)
Recommended Name: Nuclear factor interleukin-3-regulated protein  
Size: 462 amino acids; 51472 Da
Subunit: Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2R9Y8 Q14211 Q6FGQ8 Q96HS0

Explore the universe of human proteins at neXtProt for NFIL3: NX_Q16649

Explore proteomics data for NFIL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16649

  • NFIL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NFIL3 Protein Expression
    REFSEQ proteins: NP_005375.2  
    ENSEMBL proteins: 
     ENSP00000297689  

    Human Recombinant Protein Products for NFIL3: 
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    OriGene Protein Over-expression Lysate for NFIL3
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    Novus Biologicals NFIL3 Protein
    Novus Biologicals NFIL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NFIL3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    NFIL3 for ontologies           About GeneDecksing



    NFIL3 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for NFIL3 

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    Cloud-Clone Corp. CLIAs for NFIL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR016743 TF_bZIP_E4BP4
     IPR010533 Vert_IL3-reg_TF

    Graphical View of Domain Structure for InterPro Entry Q16649

    ProtoNet protein and cluster: Q16649

    UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
    Similarity: Belongs to the bZIP family. NFIL3 subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    NFIL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFIL3_HUMAN, Q16649
    Function: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3',
    a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating
    transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses
    transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on
    the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for
    the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the
    circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the
    cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity)
    Induction: Up-regulated by PHA or TPA

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA--
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding TAS1620116
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7565758
         
    NFIL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NFIL3:
     Increased cell number in G1, a 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nfil3):
     cellular  digestive/alimentary  growth/size  hematopoietic system  immune system 
     no phenotypic analysis 

    NFIL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NFIL3: Nfil3tm1Pbro Nfil3tm1Look Nfil3tm1.1Brad

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NFIL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NFIL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFIL3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFIL3 

    10/326 SABiosciences Target genes for NFIL3 (see all 326):
    ABCA12 ABCC13 ABCC4 ACTR3B ADAM23 ADAMDEC1 ADM2 AHSG AKAP3 AMPD1

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIL3:
    hsa-miR-203 hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidNFIL3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFIL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/17 Interacting proteins for NFIL3 (Q166492, 3 ENSP000002976894) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CREB3O438893, ENSP000003421364I2D: score=3 STRING: ENSP00000342136
    DR1Q016583, ENSP000003592904I2D: score=3 STRING: ENSP00000359290
    CREMQ030603I2D: score=2 
    AMOTL2Q9Y2J43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS7565758
    GO:0006955immune response TAS7565758

    NFIL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFIL3

    Search CenterWatch for drugs/clinical trials and news about NFIL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NFIL3 gene: 
    NM_005384.2  

    Unigene Cluster for NFIL3:

    Nuclear factor, interleukin 3 regulated
    Hs.79334  [show with all ESTs]
    Unigene Representative Sequence: NM_005384
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000297689
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIL3:
    hsa-miR-203 hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidNFIL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NFIL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFIL3
    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for NFIL3
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    GenScript: all cDNA clones in your preferred vector: NFIL3 (NM_005384)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIL3
    Sirion Biotech Customized lentivirus for stable overexpression of NFIL3 
                         Customized lentivirus expression plasmids for stable overexpression of NFIL3 
    Primer
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    OriGene qPCR primer pairs and template standards for NFIL3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFIL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFIL3

    Additional mRNA sequence: 

    AK313970.1 BC008197.1 CR542049.1 HM204564.1 S79880.1 U26173.1 X64318.1 

    5 DOTS entries:

    DT.314723  DT.92429461  DT.100755497  DT.92429471  DT.95372988 

    24/140 AceView cDNA sequences (see all 140):

    BM824187 BQ003179 BP345558 BG112950 BF439788 BI827337 AA370768 CR608714 
    AI823786 BC008197 BQ686697 BQ575820 BM760317 BU168451 AW768857 CR542049 
    AI039170 AI167884 BQ937243 BQ719872 CB243154 CR614563 BM699289 BU619762 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFIL3 expression in normal human tissues (normalized intensities)      NFIL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAAGGCTGT
    NFIL3 Expression
    About this image


    NFIL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Spinal Cord (Nervous System)
             Dorsal Horn   

     -- (Endocrine System)
             Pituitary gland   

    See NFIL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFIL3

    SOURCE GeneReport for Unigene cluster: Hs.79334

    UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
    Tissue specificity: Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone
    marrow and muscle

        SABiosciences Expression via Pathway-Focused PCR Array including NFIL3: 
              Circadian Rhythms in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NFIL3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfil31 , 5 nuclear factor, interleukin 3, regulated1, 5 79.54(n)1
    84.6(a)1
      13 (27.68 cM)5
    180301  NM_017373.31  NP_059069.11 
     529672095 
    chicken
    (Gallus gallus)
    Aves NFIL31 nuclear factor, interleukin 3 regulated 81.51(n)
    83.84(a)
      395326  NM_204618.1  NP_989949.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFIL36
    --
    --
    81(a)
    23(a)
    1 ↔ 1
    possible ortholog
    2(31881526-31882914)
    2(28875554-28876900)
    zebrafish
    (Danio rerio)
    Actinopterygii wufk63e102 Danio rerio cDNA clone IMAGE4786389, partial cds 73.59(n)    BC060943.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vri6
    vrille
    12(a)
    1 ↔ 1
    2L(5299647-5310996)
    worm
    (Caenorhabditis elegans)
    Secernentea atf-26
    Protein ATF-2
    15(a)
    1 ↔ 1
    II(8751986-8753939)


    ENSEMBL Gene Tree for NFIL3 (if available)
    TreeFam Gene Tree for NFIL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFIL3 gene

    NFIL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NFIL3
    PGOHUM00000234482


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/337 SNPs in NFIL3 are shown (see all 337)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7742301,2
    C--94170871(+) AGATTG/ATTATA 1 -- int14Minor allele frequency- A:0.06NA EA 244
    rs1841169041,2
    --94170991(+) ATCCAC/TGTGTC 1 -- int10--------
    rs1393277391,2
    C--94171104(+) TAATA-/TAAAG 
            
    TAATT
    1 -- int10--------
    rs1880458661,2
    --94171381(+) TATAAC/TAGAAC 1 -- ut310--------
    rs1142060361,2
    F--94171438(+) ACTATA/GCACAG 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs1924809851,2
    C--94171592(+) ATGACA/TTCTTT 1 -- ut310--------
    rs37478401,2
    C,F,H--94171628(+) GTAATT/CTACCC 2 /* syn1 ese310Minor allele frequency- C:0.00EA NS NA 6680
    rs1850398421,2
    C--94171661(+) TGTGTA/GGCTAT 2 A syn10--------
    rs1895601021,2
    C--94171666(+) GGCTAA/TAAGTC 2 I L mis10--------
    rs1506120411,2
    C,F--94171696(+) TGCAGA/GTAAGT 2 P S mis11Minor allele frequency- G:0.00NA 4550

    HapMap Linkage Disequilibrium report for NFIL3 (94171327 - 94186144 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NFIL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv824981CNV Gain20364138
    nsv893571CNV Gain21882294
    nsv824980CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605327    OMIM disorders: --

    12 diseases for NFIL3:    About MalaCards
    bipolar i disorder    hereditary sensory neuropathy    schizoaffective disorder    autism spectrum disorder
    attention deficit hyperactivity disorder    hepatitis b    multiple myeloma    neuropathy
    myeloma    schizophrenia    hepatitis    thyroiditis


    NFIL3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NFIL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 14.9 2 10074173 (1), 10627534 (1)

    Genetic Association Database (GAD): NFIL3
    Human Genome Epidemiology (HuGE) Navigator: NFIL3 (7 documents)

    Export disorders for NFIL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFIL3 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with NFIL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. (PubMed id 7565758)1, 2, 3, 9 Zhang W.... Nimer S.D. (1995)
    2. Transcriptional repression by a novel member of the bZIP family of transcription factors. (PubMed id 1620116)1, 2, 3 Cowell I.G....Hurst H.C. (1992)
    3. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. (PubMed id 8836190)1, 2, 9 Cowell I.G. and Hurst H.C. (1996)
    4. Systematic analysis of circadian genes in a populatio n-based sample reveals association of TIMELESS with depression and sleep distur bance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. PER2 variantion is associated with depression vulnera bility. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (2010)
    7. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (2009)
    8. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    9. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PubMed id 18937294)1, 4 Lasky-Su J....Faraone S.V. (2008)
    10. Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis. (PubMed id 10942106)1, 2 Hulme D.J.... Nicholson G.A. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4783 HGNC: 7787 AceView: NFIL3 Ensembl:ENSG00000165030 euGenes: HUgn4783
    ECgene: NFIL3 H-InvDB: NFIL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFIL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NFIL3 gene:
    Search GeneIP for patents involving NFIL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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