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NFIL3 Gene

protein-coding   GIFtS: 52
GCID: GC09M094171

Nuclear Factor, Interleukin 3 Regulated


(Previous symbol: IL3BP1)
  See NFIL3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor, Interleukin 3 Regulated1 2     E4 Promoter-Binding Protein 42 3
IL3BP11 2 3     NFIL3A2 5
E4BP42 3 5     NF-IL3A2
Interleukin-3 Promoter Transcriptional Activator2 3     Nuclear Factor Interleukin 3 Regulated Protein2
Interleukin-3-Binding Protein 12 3     Nuclear Factor Interleukin-3-Regulated Protein2
Transcriptional Activator NF-IL3A2 3     

External Ids:    HGNC: 77871   Entrez Gene: 47832   Ensembl: ENSG000001650307   OMIM: 6053275   UniProtKB: Q166493   

Export aliases for NFIL3 gene to outside databases

Previous GC identifers: GC09M085011 GC09M085899 GC09M087470 GC09M089512 GC09M091250 GC09M093211 GC09M063851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFIL3 Gene:
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating
transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and
PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Feb 2014)

GeneCards Summary for NFIL3 Gene:
NFIL3 (nuclear factor, interleukin 3 regulated) is a protein-coding gene. Diseases associated with NFIL3 include autism spectrum disorder. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
Function: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3',
a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating
transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses
transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on
the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for
the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the
circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the
cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity)

Gene Wiki entry for NFIL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFIL3 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   CREB   COUP-TF   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFIL3 promoter sequence
   Search Chromatin IP Primers for NFIL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFIL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22

NFIL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIL3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M094171:  view genomic region     (about GC identifiers)

Start:
94,171,327 bp from pter      End:
94,186,144 bp from pter
Size:
14,818 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649 (See protein sequence)
Recommended Name: Nuclear factor interleukin-3-regulated protein  
Size: 462 amino acids; 51472 Da
Subunit: Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2 (By similarity)
Secondary accessions: B2R9Y8 Q14211 Q6FGQ8 Q96HS0

Explore the universe of human proteins at neXtProt for NFIL3: NX_Q16649

Explore proteomics data for NFIL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFIL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276928.1  NP_001276929.1  NP_005375.2  

    ENSEMBL proteins: 
     ENSP00000297689  

    NFIL3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NFIL3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR016743 TF_bZIP_E4BP4
     IPR010533 Vert_IL3-reg_TF

    Graphical View of Domain Structure for InterPro Entry Q16649

    ProtoNet protein and cluster: Q16649

    UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
    Similarity: Belongs to the bZIP family. NFIL3 subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with NFIL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFIL3_HUMAN, Q16649
    Function: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3',
    a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating
    transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses
    transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on
    the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for
    the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the
    circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the
    cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity)
    Induction: Up-regulated by PHA or TPA

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA--
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding TAS1620116
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7565758
         
    Find genes that share ontologies with NFIL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NFIL3:
     Increased cell number in G1, a 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nfil3):
     digestive/alimentary  growth/size/body  hematopoietic system  immune system  no phenotypic analysis 

    Find genes that share phenotypes with NFIL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NFIL3: Nfil3tm1Pbro Nfil3tm1Look Nfil3tm1.1Brad

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFIL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFIL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFIL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFIL3

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NFIL3 (see all 320):
    ABCA12,  ABCC13,  ABCC4,  ACTR3B,  ADAM23,  ADAMDEC1,  ADM2,  AHSG,  AKAP3,  AMPD1

    miRNA
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    miRTarBase miRNAs that target NFIL3:
    hsa-mir-335-5p (MIRT018550), hsa-mir-98-5p (MIRT027704)

    Block miRNA regulation of human, mouse, rat NFIL3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate NFIL3:
    hsa-miR-203 hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidNFIL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFIL3
    Predesigned siRNA for gene silencing in human, mouse, rat NFIL3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NFIL3 (NM_005384)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIL3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFIL3_HUMAN, Q16649: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with NFIL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NFIL3: 
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFIL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFIL3 (Q166492, 3 ENSP000002976894) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CREB3O438893, ENSP000003421364I2D: score=3 STRING: ENSP00000342136
    DR1Q016583, ENSP000003592904I2D: score=3 STRING: ENSP00000359290
    CREMQ030603I2D: score=2 
    AMOTL2Q9Y2J43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS7565758
    GO:0006955immune response TAS7565758

    Find genes that share ontologies with NFIL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFIL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NFIL3 gene (3 alternative transcripts): 
    NM_001289999.1  NM_001290000.1  NM_005384.2  

    Unigene Cluster for NFIL3:

    Nuclear factor, interleukin 3 regulated
    Hs.79334  [show with all ESTs]
    Unigene Representative Sequence: NM_005384
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000297689
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate NFIL3:
    hsa-miR-203 hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidNFIL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFIL3
    Predesigned siRNA for gene silencing in human, mouse, rat NFIL3
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    OriGene ORF clones in mouse, rat for NFIL3
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    GenScript: all cDNA clones in your preferred vector: NFIL3 (NM_005384)
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    Primer
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    OriGene qPCR primer pairs and template standards for NFIL3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFIL3
      QuantiTect SYBR Green Assays in human, mouse, rat NFIL3
      QuantiFast Probe-based Assays in human, mouse, rat NFIL3

    Additional mRNA sequence: 

    AK313970.1 BC008197.1 CR542049.1 HM204564.1 S79880.1 U26173.1 X64318.1 

    5 DOTS entries:

    DT.314723  DT.92429461  DT.100755497  DT.92429471  DT.95372988 

    Selected AceView cDNA sequences (see all 140):

    AA370768 AI039170 AI167884 CB152863 CR608714 BU619762 BQ719872 CR542049 
    BM699289 BQ937243 CR599259 AI823786 BQ686697 BF439788 BU168451 CR614563 
    BM824187 BM760317 CA447529 BG112950 CA487715 BP345558 BX417939 BQ003179 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NFIL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAAGGCTGT
    NFIL3 Expression
    About this image


    NFIL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Adrenal Gland (Endocrine System)
    NFIL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFIL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79334

    UniProtKB/Swiss-Prot: NFIL3_HUMAN, Q16649
    Tissue specificity: Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone
    marrow and muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including NFIL3: 
              Circadian Rhythms in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for NFIL3
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    QuantiFast Probe-based Assays in human, mouse, rat NFIL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NFIL3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfil31 , 5 nuclear factor, interleukin 3, regulated1, 5 79.54(n)1
    84.6(a)1
      13 (27.68 cM)5
    180301  NM_017373.31  NP_059069.11 
     529672095 
    chicken
    (Gallus gallus)
    Aves NFIL31 nuclear factor, interleukin 3 regulated 81.51(n)
    83.84(a)
      395326  NM_204618.1  NP_989949.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFIL36
    nuclear factor, interleukin 3 regulated
    81(a)
    1 ↔ 1
    2(31881526-31882914)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nfil31 nuclear factor, interleukin 3 regulated 70.07(n)
    69.2(a)
      548427  NM_001015710.1  NP_001015710.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk63e102 Danio rerio cDNA clone IMAGE4786389, partial cds 73.59(n)    BC060943.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vri6
    vrille
    11(a)
    1 ↔ 1
    2L(5299647-5310996)
    worm
    (Caenorhabditis elegans)
    Secernentea atf-26
    Protein ATF-2 (atf-2) mRNA, complete cds
    20(a)
    1 ↔ 1
    II(8751986-8753939) WBGene00000220


    ENSEMBL Gene Tree for NFIL3 (if available)
    TreeFam Gene Tree for NFIL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFIL3 gene

    Find genes that share paralogs with NFIL3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NFIL3
    PGOHUM00000234482


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFIL3 (see all 337)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7742301,2
    C--94170871(+) AGATTG/ATTATA 1 -- int14Minor allele frequency- A:0.06NA EA 244
    rs1841169041,2
    --94170991(+) ATCCAC/TGTGTC 1 -- int10--------
    rs1393277391,2
    C--94171104(+) TAATA-/TAAAG 
            
    TAATT
    1 -- int10--------
    rs1880458661,2
    --94171381(+) TATAAC/TAGAAC 1 -- ut310--------
    rs1142060361,2
    F--94171438(+) ACTATA/GCACAG 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs1924809851,2
    C--94171592(+) ATGACA/TTCTTT 1 -- ut310--------
    rs37478401,2
    C,F,H--94171628(+) GTAATT/CTACCC 2 /* syn1 ese310Minor allele frequency- C:0.00EA NS NA 6680
    rs1850398421,2
    C--94171661(+) TGTGTA/GGCTAT 2 A syn10--------
    rs1895601021,2
    C--94171666(+) GGCTAA/TAAGTC 2 I L mis10--------
    rs1506120411,2
    C,F--94171696(+) TGCAGA/GTAAGT 2 P S mis11Minor allele frequency- G:0.00NA 4550

    HapMap Linkage Disequilibrium report for NFIL3 (94171327 - 94186144 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NFIL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv824981CNV Gain20364138
    nsv893571CNV Gain21882294
    nsv824980CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605327    OMIM disorders: --

    1 disease for NFIL3:    
    About MalaCards
    autism spectrum disorder


    Find genes that share disorders with NFIL3           About GenesLikeMe

    1 Novoseek inferred disease relationship for NFIL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 14.9 2 10074173 (1), 10627534 (1)

    Genetic Association Database (GAD): NFIL3
    Human Genome Epidemiology (HuGE) Navigator: NFIL3 (7 documents)

    Export disorders for NFIL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFIL3 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with NFIL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. (PubMed id 7565758)1, 2, 3, 9 Zhang W.... Nimer S.D. (Mol. Cell. Biol. 1995)
    2. Transcriptional repression by a novel member of the bZIP family of transcription factors. (PubMed id 1620116)1, 2, 3 Cowell I.G.... Hurst H.C. (Mol. Cell. Biol. 1992)
    3. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. (PubMed id 8836190)1, 2, 9 Cowell I.G. and Hurst H.C. (Nucleic Acids Res. 1996)
    4. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (PLoS ONE 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. PER2 variantion is associated with depression vulnerability. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (Bipolar Disord 2009)
    8. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    9. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PubMed id 18937294)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    10. Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis. (PubMed id 10942106)1, 2 Hulme D.J.... Nicholson G.A. (Hum. Genet. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4783 HGNC: 7787 AceView: NFIL3 Ensembl:ENSG00000165030 euGenes: HUgn4783
    ECgene: NFIL3 H-InvDB: NFIL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NFIL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFIL3 gene:
    Search GeneIP for patents involving NFIL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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