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Aliases for NFIL3 Gene

Aliases for NFIL3 Gene

  • Nuclear Factor, Interleukin 3 Regulated 2 3 5
  • Interleukin-3 Promoter Transcriptional Activator 3 4
  • Transcriptional Activator NF-IL3A 3 4
  • Interleukin-3-Binding Protein 1 3 4
  • E4 Promoter-Binding Protein 4 3 4
  • IL3BP1 3 4
  • E4BP4 3 4
  • Nuclear Factor Interleukin-3-Regulated Protein 3
  • NF-IL3A 3
  • NFIL3A 3

External Ids for NFIL3 Gene

Previous HGNC Symbols for NFIL3 Gene

  • IL3BP1

Previous GeneCards Identifiers for NFIL3 Gene

  • GC09M085011
  • GC09M085899
  • GC09M087470
  • GC09M089512
  • GC09M091250
  • GC09M093211
  • GC09M094171
  • GC09M063851

Summaries for NFIL3 Gene

Entrez Gene Summary for NFIL3 Gene

  • The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for NFIL3 Gene

NFIL3 (Nuclear Factor, Interleukin 3 Regulated) is a Protein Coding gene. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Development IGF-1 receptor signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for NFIL3 Gene

  • Acts as a transcriptional regulator that recognizes and binds to the sequence 5-[GA]TTA[CT]GTAA[CT]-3, a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity).

Gene Wiki entry for NFIL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFIL3 Gene

Genomics for NFIL3 Gene

Regulatory Elements for NFIL3 Gene

Enhancers for NFIL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F091417 1.5 FANTOM5 ENCODE 31 +3.1 3108 8.7 MLX ARID4B SIN3A DMAP1 YY1 FOS PAF1 SP3 SP5 ZHX2 NFIL3 LOC105376146 SPTLC1 AUH
GH09F091191 1.9 FANTOM5 Ensembl ENCODE 18.7 +229.0 229026 9.2 PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 NFIL3 LINC00484 LINC00475 LOC105376146 SYK ENSG00000273381 LOC100507103 ENSG00000230147
GH09F091415 1.3 FANTOM5 Ensembl ENCODE 19.5 +8.6 8626 2.0 SOX13 KLF1 PKNOX1 SAP130 JUN ZMYM3 POLR2A FOS MAFK MIXL1 NFIL3 AUH
GH09F091098 1.7 FANTOM5 Ensembl ENCODE 12.8 +324.0 324013 4.0 MLX ARID4B FEZF1 DMAP1 ZNF48 ZNF2 YY1 SLC30A9 FOS ZNF263 NFIL3 LOC105376146 ENSG00000229694 SYK LINC00484 LOC100129316
GH09F091300 1.1 Ensembl ENCODE 14.9 +122.1 122094 3.5 ELF3 CTCF IRF2 ARNT GTF2E2 JUN RAD21 RFX5 GATA3 ZNF143 NFIL3 LOC105376146 LINC00484 ENSG00000273381 GC09M091273 AUH
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFIL3 on UCSC Golden Path with GeneCards custom track

Promoters for NFIL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001472613 1526 4601 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS PAF1 SP5

Genomic Location for NFIL3 Gene

Chromosome:
9
Start:
91,409,045 bp from pter
End:
91,424,626 bp from pter
Size:
15,582 bases
Orientation:
Minus strand

Genomic View for NFIL3 Gene

Genes around NFIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFIL3 Gene

Proteins for NFIL3 Gene

  • Protein details for NFIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16649-NFIL3_HUMAN
    Recommended name:
    Nuclear factor interleukin-3-regulated protein
    Protein Accession:
    Q16649
    Secondary Accessions:
    • B2R9Y8
    • Q14211
    • Q6FGQ8
    • Q96HS0

    Protein attributes for NFIL3 Gene

    Size:
    462 amino acids
    Molecular mass:
    51472 Da
    Quaternary structure:
    • Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2 (By similarity).

neXtProt entry for NFIL3 Gene

Post-translational modifications for NFIL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFIL3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NFIL3 (E4BP4)

No data available for DME Specific Peptides for NFIL3 Gene

Domains & Families for NFIL3 Gene

Gene Families for NFIL3 Gene

Protein Domains for NFIL3 Gene

Suggested Antigen Peptide Sequences for NFIL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q16649

UniProtKB/Swiss-Prot:

NFIL3_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. NFIL3 subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. NFIL3 subfamily.
genes like me logo Genes that share domains with NFIL3: view

Function for NFIL3 Gene

Molecular function for NFIL3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional regulator that recognizes and binds to the sequence 5-[GA]TTA[CT]GTAA[CT]-3, a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by PHA or TPA.

Gene Ontology (GO) - Molecular Function for NFIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 20093779
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 20093779
GO:0003677 DNA binding TAS 1620116
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 7565758
genes like me logo Genes that share ontologies with NFIL3: view
genes like me logo Genes that share phenotypes with NFIL3: view

Animal Models for NFIL3 Gene

MGI Knock Outs for NFIL3:

Animal Model Products

miRNA for NFIL3 Gene

miRTarBase miRNAs that target NFIL3

Transcription Factor Targets for NFIL3 Gene

Selected GeneGlobe predicted Target genes for NFIL3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for NFIL3 Gene

Localization for NFIL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFIL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFIL3 gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for NFIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with NFIL3: view

Pathways & Interactions for NFIL3 Gene

genes like me logo Genes that share pathways with NFIL3: view

Pathways by source for NFIL3 Gene

1 Cell Signaling Technology pathway for NFIL3 Gene
1 BioSystems pathway for NFIL3 Gene

Gene Ontology (GO) - Biological Process for NFIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 20093779
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA,TAS --
GO:0006955 immune response IEA,TAS --
genes like me logo Genes that share ontologies with NFIL3: view

No data available for SIGNOR curated interactions for NFIL3 Gene

Transcripts for NFIL3 Gene

mRNA/cDNA for NFIL3 Gene

Unigene Clusters for NFIL3 Gene

Nuclear factor, interleukin 3 regulated:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFIL3 Gene

No ASD Table

Relevant External Links for NFIL3 Gene

GeneLoc Exon Structure for
NFIL3
ECgene alternative splicing isoforms for
NFIL3

Expression for NFIL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFIL3 Gene

This gene is overexpressed in Whole Blood (x6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFIL3 Gene



NURSA nuclear receptor signaling pathways regulating expression of NFIL3 Gene:

NFIL3

SOURCE GeneReport for Unigene cluster for NFIL3 Gene:

Hs.79334

mRNA Expression by UniProt/SwissProt for NFIL3 Gene:

Q16649-NFIL3_HUMAN
Tissue specificity: Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.
genes like me logo Genes that share expression patterns with NFIL3: view

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NFIL3 Gene

Orthologs for NFIL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFIL3 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia NFIL3 34 35
  • 87.01 (n)
oppossum
(Monodelphis domestica)
Mammalia NFIL3 35
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFIL3 34 35
  • 79.58 (n)
mouse
(Mus musculus)
Mammalia Nfil3 34 16 35
  • 79.54 (n)
rat
(Rattus norvegicus)
Mammalia Nfil3 34
  • 79.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFIL3 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFIL3 34 35
  • 81.51 (n)
lizard
(Anolis carolinensis)
Reptilia NFIL3 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfil3 34
  • 70.07 (n)
zebrafish
(Danio rerio)
Actinopterygii nfil3 34 35
  • 58.35 (n)
wufk63e10 34
fruit fly
(Drosophila melanogaster)
Insecta vri 35
  • 11 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea atf-2 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
OneToOne
Species where no ortholog for NFIL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFIL3 Gene

ENSEMBL:
Gene Tree for NFIL3 (if available)
TreeFam:
Gene Tree for NFIL3 (if available)

Paralogs for NFIL3 Gene

Pseudogenes.org Pseudogenes for NFIL3 Gene

genes like me logo Genes that share paralogs with NFIL3: view

No data available for Paralogs for NFIL3 Gene

Variants for NFIL3 Gene

Sequence variations from dbSNP and Humsavar for NFIL3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10116162 -- 91,426,574(+) CTCAG(C/T)GCTAG intron-variant, upstream-variant-2KB
rs10608008 -- 91,418,856(+) GGGTG(-/T)TTTTT intron-variant
rs10820851 -- 91,416,161(+) TTCTT(C/T)TTTTT intron-variant
rs10820852 -- 91,424,691(+) GAGGT(A/C)CATCT intron-variant, upstream-variant-2KB
rs10991924 -- 91,411,628(+) TTCTT(C/T)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFIL3 Gene

Variant ID Type Subtype PubMed ID
nsv950890 CNV duplication 24416366
nsv824981 CNV gain 20364138
nsv824980 CNV gain 20364138
nsv614857 CNV loss 21841781
nsv1075253 CNV deletion 25765185
dgv4098n106 CNV deletion 24896259

Variation tolerance for NFIL3 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFIL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFIL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFIL3 Gene

Disorders for NFIL3 Gene

Relevant External Links for NFIL3

Genetic Association Database (GAD)
NFIL3
Human Genome Epidemiology (HuGE) Navigator
NFIL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFIL3

No disorders were found for NFIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFIL3 Gene

Publications for NFIL3 Gene

  1. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. (PMID: 7565758) Zhang W. … Nimer S.D. (Mol. Cell. Biol. 1995) 2 3 4 22 64
  2. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. (PMID: 8836190) Cowell I.G. … Hurst H.C. (Nucleic Acids Res. 1996) 3 4 22 64
  3. Transcriptional repression by a novel member of the bZIP family of transcription factors. (PMID: 1620116) Cowell I.G. … Hurst H.C. (Mol. Cell. Biol. 1992) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. PER2 variantion is associated with depression vulnerability. (PMID: 19693801) Lavebratt C. … Forsell Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64

Products for NFIL3 Gene

Sources for NFIL3 Gene

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