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Aliases for NFIC Gene

Aliases for NFIC Gene

  • Nuclear Factor I C 2 3 5
  • Nuclear Factor I/C (CCAAT-Binding Transcription Factor) 2 3
  • CCAAT-Box-Binding Transcription Factor 3 4
  • TGGCA-Binding Protein 3 4
  • NF-I/C 3 4
  • NF1-C 3 4
  • CTF 3 4
  • NFI 3 4
  • CCAAT-Binding Transcription Factor 2
  • Nuclear Factor 1 C-Type 3
  • Nuclear Factor 1/C 4
  • Nuclear Factor I/C 4
  • NFI-C 4
  • CTF5 3
  • NF-I 3

External Ids for NFIC Gene

Previous HGNC Symbols for NFIC Gene

  • NFI

Previous GeneCards Identifiers for NFIC Gene

  • GC19P003458
  • GC19P003306
  • GC19P003318
  • GC19P003319
  • GC19P003310
  • GC19P003126

Summaries for NFIC Gene

Entrez Gene Summary for NFIC Gene

  • The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NFIC Gene

NFIC (Nuclear Factor I C) is a Protein Coding gene. Diseases associated with NFIC include Common Wart and Marshall-Smith Syndrome. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NFIA.

UniProtKB/Swiss-Prot for NFIC Gene

  • Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene Wiki entry for NFIC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFIC Gene

Genomics for NFIC Gene

Regulatory Elements for NFIC Gene

Enhancers for NFIC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G003402 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +46.6 46592 7.9 FOXA2 MLX ZFP64 ARID4B YY1 ZNF121 FOS ZNF263 ZHX2 REST NFIC PIP5K1C TLE2 ATCAY ENSG00000279599 SMIM24
GH19G003450 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.9 +92.8 92763 3.9 ATF1 MLX SIN3A BRCA1 ZNF121 FOS JUNB TSHZ1 ZNF662 ZNF623 NFIC SMIM24 GNA15 ENSG00000279599
GH19G003455 1.4 Ensembl ENCODE dbSUPER 9.7 +98.8 98822 5.1 FOXA2 KLF17 RARA TCF12 GLIS2 EGR2 ZNF263 REST NR2F2 MAFF NFIC SMIM24 ENSG00000279599
GH19G003386 1.5 Ensembl ENCODE dbSUPER 9 +29.0 29019 4.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 TCF12 JUNB NCOA1 NFIC SMIM24 DOHH ENSG00000279599
GH19G003413 1.2 ENCODE dbSUPER 10.8 +54.5 54475 0.2 FOXA2 MLX ARID4B ZNF48 YY1 TCF12 ZNF143 SP5 MXD4 MIER2 NFIC ENSG00000279599 SMIM24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFIC on UCSC Golden Path with GeneCards custom track

Promoters for NFIC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106031 637 2401 HDGF SIN3A DMAP1 YY1 KLF13 SP3 MXD4 ZNF592 SMARCA4 GLIS1

Genomic Location for NFIC Gene

Chromosome:
19
Start:
3,359,563 bp from pter
End:
3,469,217 bp from pter
Size:
109,655 bases
Orientation:
Plus strand

Genomic View for NFIC Gene

Genes around NFIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFIC Gene

Proteins for NFIC Gene

  • Protein details for NFIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08651-NFIC_HUMAN
    Recommended name:
    Nuclear factor 1 C-type
    Protein Accession:
    P08651
    Secondary Accessions:
    • A8K1H0
    • B7Z4U5
    • B7Z9C3
    • K7EMU1
    • P08652
    • Q14932
    • Q9UPJ3
    • Q9UPJ9
    • Q9UPK0
    • Q9UPK1

    Protein attributes for NFIC Gene

    Size:
    508 amino acids
    Molecular mass:
    55675 Da
    Quaternary structure:
    • Binds DNA as a homodimer.

    Alternative splice isoforms for NFIC Gene

neXtProt entry for NFIC Gene

Post-translational modifications for NFIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFIC Gene

Domains & Families for NFIC Gene

Suggested Antigen Peptide Sequences for NFIC Gene

Graphical View of Domain Structure for InterPro Entry

P08651

UniProtKB/Swiss-Prot:

NFIC_HUMAN :
  • Belongs to the CTF/NF-I family.
Family:
  • Belongs to the CTF/NF-I family.
genes like me logo Genes that share domains with NFIC: view

No data available for Gene Families for NFIC Gene

Function for NFIC Gene

Molecular function for NFIC Gene

GENATLAS Biochemistry:
nuclear transcription factor I C,DNA binding protein
UniProtKB/Swiss-Prot Function:
Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene Ontology (GO) - Molecular Function for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 1524678
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 1524678
GO:0001159 core promoter proximal region DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with NFIC: view
genes like me logo Genes that share phenotypes with NFIC: view

Animal Models for NFIC Gene

MGI Knock Outs for NFIC:

Animal Model Products

CRISPR Products

miRNA for NFIC Gene

miRTarBase miRNAs that target NFIC

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFIC Gene

Localization for NFIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFIC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFIC gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with NFIC: view

Pathways & Interactions for NFIC Gene

genes like me logo Genes that share pathways with NFIC: view

Gene Ontology (GO) - Biological Process for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IGI 1524678
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8710515
genes like me logo Genes that share ontologies with NFIC: view

No data available for SIGNOR curated interactions for NFIC Gene

Drugs & Compounds for NFIC Gene

(4) Drugs for NFIC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for NFIC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFIC: view

Transcripts for NFIC Gene

Unigene Clusters for NFIC Gene

Nuclear factor I/C (CCAAT-binding transcription factor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFIC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for NFIC Gene

GeneLoc Exon Structure for
NFIC
ECgene alternative splicing isoforms for
NFIC

Expression for NFIC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFIC Gene

mRNA differential expression in normal tissues according to GTEx for NFIC Gene

This gene is overexpressed in Muscle - Skeletal (x4.9).

Protein differential expression in normal tissues from HIPED for NFIC Gene

This gene is overexpressed in Ovary (12.0) and Fetal testis (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFIC Gene



Protein tissue co-expression partners for NFIC Gene

NURSA nuclear receptor signaling pathways regulating expression of NFIC Gene:

NFIC

SOURCE GeneReport for Unigene cluster for NFIC Gene:

Hs.170131

Evidence on tissue expression from TISSUES for NFIC Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Heart(4.4)
  • Eye(3.2)
  • Lung(3)
  • Muscle(2.8)
  • Kidney(2.4)
  • Skin(2)
genes like me logo Genes that share expression patterns with NFIC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFIC Gene

Orthologs for NFIC Gene

This gene was present in the common ancestor of animals.

Orthologs for NFIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFIC 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFIC 34 35
  • 94.14 (n)
cow
(Bos Taurus)
Mammalia NFIC 34 35
  • 93.07 (n)
rat
(Rattus norvegicus)
Mammalia Nfic 34
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Nfic 34 16 35
  • 89.28 (n)
oppossum
(Monodelphis domestica)
Mammalia NFIC 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFIC 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 94 (a)
OneToMany
NFIC 34
  • 86.06 (n)
-- 35
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NFIC 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfic 34
  • 72.64 (n)
zebrafish
(Danio rerio)
Actinopterygii nfic 35
  • 84 (a)
OneToOne
LOC100005568 34
  • 77.36 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta NFI 34
  • 68.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2380 36
  • 41 (a)
NfI 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nfi-1 36 35
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for NFIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFIC Gene

ENSEMBL:
Gene Tree for NFIC (if available)
TreeFam:
Gene Tree for NFIC (if available)

Paralogs for NFIC Gene

Paralogs for NFIC Gene

(5) SIMAP similar genes for NFIC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFIC: view

Variants for NFIC Gene

Sequence variations from dbSNP and Humsavar for NFIC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000065890 -- 3,364,784(+) GGTCT(A/G)GAAGT intron-variant, upstream-variant-2KB
rs1000090492 -- 3,465,985(+) CCCCC(A/G)TCCCC utr-variant-3-prime
rs1000094901 -- 3,401,500(+) CTCTC(C/T)TTGCC intron-variant
rs1000120621 -- 3,388,949(+) GCAGC(A/G)AGCTG intron-variant
rs1000127923 -- 3,396,756(+) TTCGA(A/G)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFIC Gene

Variant ID Type Subtype PubMed ID
esv1167286 CNV deletion 17803354
esv2671745 CNV deletion 23128226
esv2717945 CNV deletion 23290073
esv3555881 CNV deletion 23714750
esv3643462 CNV loss 21293372
esv3643464 CNV loss 21293372
nsv1058546 CNV gain 25217958
nsv1071497 CNV deletion 25765185
nsv1071498 CNV deletion 25765185
nsv1112742 CNV deletion 24896259
nsv1116291 CNV deletion 24896259
nsv1118804 CNV deletion 24896259
nsv1121965 CNV deletion 24896259
nsv1126507 CNV deletion 24896259
nsv1131386 CNV deletion 24896259
nsv1133439 CNV deletion 24896259
nsv1149132 CNV deletion 26484159
nsv470114 CNV loss 18288195
nsv479906 CNV novel sequence insertion 20440878
nsv509717 CNV insertion 20534489
nsv526602 CNV loss 19592680
nsv833712 CNV loss 17160897
nsv953948 CNV deletion 24416366

Variation tolerance for NFIC Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFIC Gene

Disorders for NFIC Gene

MalaCards: The human disease database

(3) MalaCards diseases for NFIC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
common wart
marshall-smith syndrome
  • mrshss
peripheral nervous system neoplasm
  • neoplasm of peripheral nerve
- elite association - COSMIC cancer census association via MalaCards
Search NFIC in MalaCards View complete list of genes associated with diseases

Relevant External Links for NFIC

Genetic Association Database (GAD)
NFIC
Human Genome Epidemiology (HuGE) Navigator
NFIC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFIC
genes like me logo Genes that share disorders with NFIC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFIC Gene

Publications for NFIC Gene

  1. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PMID: 7590749) Qian F. … Sippel A.E. (Genomics 1995) 2 3 22 64
  2. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. (PMID: 3398920) Santoro C. … Tjian R. (Nature 1988) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  5. Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts. (PMID: 18809517) PAcrez-Casellas L.A. … Linkhart T.A. (Biochim. Biophys. Acta 2009) 3 22 64

Products for NFIC Gene

Sources for NFIC Gene

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