Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NFIC Gene

protein-coding   GIFtS: 62
GCID: GC19P003359

Nuclear Factor I/C (CCAAT-Binding Transcription Factor)


(Previous symbol: NFI)
  See NFIC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Factor I/C (CCAAT-Binding Transcription Factor)1 2     CTF52
NFI1 2 3     NF-I2
CTF2 3     Nuclear Factor 1 C-Type2
NF-I/C2 3     NFI-C3
NF1-C2 3     Nuclear Factor 1/C3
CCAAT-Box-Binding Transcription Factor2 3     Nuclear Factor I/C3
TGGCA-Binding Protein2 3     

External Ids:    HGNC: 77861   Entrez Gene: 47822   Ensembl: ENSG000001419057   OMIM: 6007295   UniProtKB: P086513   

Export aliases for NFIC gene to outside databases

Previous GC identifers: GC19P003458 GC19P003306 GC19P003318 GC19P003319 GC19P003310 GC19P003126


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NFIC Gene:
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and
function as cellular transcription factors and as replication factors for adenovirus DNA replication.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
(provided by RefSeq, Oct 2011)

GeneCards Summary for NFIC Gene:
NFIC (nuclear factor I/C (CCAAT-binding transcription factor)) is a protein-coding gene. Diseases associated with NFIC include common wart. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFIB.

UniProtKB/Swiss-Prot: NFIC_HUMAN, P08651
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular
promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of
activating transcription and replication

Gene Wiki entry for NFIC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFIC gene promoter:
         GR   AP-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NFIC promoter sequence
   Search Chromatin IP Primers for NFIC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

NFIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003359:  view genomic region     (about GC identifiers)

Start:
3,359,561 bp from pter      End:
3,469,215 bp from pter
Size:
109,655 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NFIC_HUMAN, P08651 (See protein sequence)
Recommended Name: Nuclear factor 1 C-type  
Size: 508 amino acids; 55675 Da
Subunit: Binds DNA as a homodimer
Secondary accessions: A8K1H0 B7Z4U5 B7Z9C3 K7EMU1 P08652 Q14932 Q9UPJ3 Q9UPJ9 Q9UPK0 Q9UPK1
Alternative splicing: 6 isoforms:  P08651-1   P08651-2   P08651-3   P08651-4   P08651-5   P08651-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFIC: NX_P08651

Explore proteomics data for NFIC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFIC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001231931.1  NP_001231933.1  NP_001231934.1  NP_005588.2  NP_995315.1  

    ENSEMBL proteins: 
     ENSP00000465655   ENSP00000378543   ENSP00000465177   ENSP00000342194   ENSP00000466647  
     ENSP00000396843   ENSP00000301935  
    Reactome Protein details: P08651

    NFIC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NFIC
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for NFIC
    OriGene Custom Protein Services for NFIC
    GenScript Custom Purified and Recombinant Proteins Services for NFIC
    Novus Biologicals NFIC Proteins
    Novus Biologicals NFIC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NFIC

     
    Search eBioscience for Proteins for NFIC 

    NFIC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NFIC  (NFI-C)
    OriGene Antibodies for NFIC
    OriGene Custom Antibody Services for NFIC
    Novus Biologicals NFIC Antibodies
    Abcam antibodies for NFIC
    Cloud-Clone Corp. Antibodies for NFIC
    ThermoFisher Antibodies for NFIC
    LSBio Antibodies in human, mouse, rat for NFIC

    NFIC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFIC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFIC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NFIC
    Cloud-Clone Corp. CLIAs for NFIC
    Search eBioscience for ELISAs for NFIC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR000647 CTF/NFI
     IPR019548 CTF/NFI_DNA-bd_N
     IPR019739 CTF/NFI_DNA-bd_CS
     IPR003619 MAD_homology1_Dwarfin-type
     IPR020604 CTF/NFI_DNA-bd-dom

    Graphical View of Domain Structure for InterPro Entry P08651

    ProtoNet protein and cluster: P08651

    2 Blocks protein domains:
    IPB000647 CTF/NF-I family
    IPB009044 ssDNA-binding transcriptional regulator


    UniProtKB/Swiss-Prot: NFIC_HUMAN, P08651
    Similarity: Belongs to the CTF/NF-I family
    Similarity: Contains 1 CTF/NF-I DNA-binding domain


    Find genes that share domains with NFIC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFIC_HUMAN, P08651
    Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular
    promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of
    activating transcription and replication

         Genatlas biochemistry entry for NFIC:
    nuclear transcription factor I C,DNA binding protein

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001159core promoter proximal region DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA1524678
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NFIC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NFIC:
     Big cells 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nfic):
     behavior/neurological  craniofacial  growth/size/body  mortality/aging  nervous system 
     reproductive system  skeleton 

    Find genes that share phenotypes with NFIC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nfictm1Rmg for NFIC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFIC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFIC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFIC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFIC

    miRNA
    Products:
        
    miRTarBase miRNAs that target NFIC:
    hsa-mir-124-3p (MIRT002601), hsa-mir-339-5p (MIRT042760), hsa-mir-18a-3p (MIRT040932)

    Block miRNA regulation of human, mouse, rat NFIC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFIC (see all 9):
    hsa-miR-15a hsa-miR-497 hsa-miR-511 hsa-miR-424 hsa-miR-143 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidNFIC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFIC
    Predesigned siRNA for gene silencing in human, mouse, rat NFIC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFIC

    Clone
    Products:
         
    OriGene clones in human, mouse for NFIC (see all 14)
    OriGene ORF clones in mouse, rat for NFIC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFIC (NM_005597)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFIC
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFIC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NFIC_HUMAN, P08651: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex ----
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with NFIC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NFIC About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Termination0.58
    RNA Polymerase III Transcription0.88
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    3Gene Expression
    Gene Expression0.40
    4FOXA1 transcription factor network
    FOXA1 transcription factor network


    Find genes that share SuperPaths with NFIC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NFIC
        FOXA1 transcription factor network

    2 Reactome Pathways for NFIC
        RNA Polymerase III Transcription Termination
    RNA Polymerase III Abortive And Retractive Initiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NFIC
    Interactions:

        GeneGlobe Interaction Network for NFIC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFIC (P086512, 3 ENSP000003968434) via UniProtKB, MINT, STRING, and/or I2D (see all 629)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TKTL2Q9H0I92, 3, ENSP000002806054MINT-67467 I2D: score=4 STRING: ENSP00000280605
    RBMXP381592, 3MINT-7945693 I2D: score=1 
    LLPHQ9BRT62, 3, ENSP000002666044MINT-66158 I2D: score=4 STRING: ENSP00000266604
    TPD52L3Q96J772, 3, ENSP000003416774MINT-66242 I2D: score=4 STRING: ENSP00000341677
    ZKSCAN7Q9P0L13, ENSP000002733204I2D: score=3 STRING: ENSP00000273320
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IGI1524678
    GO:0006260DNA replication IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS8710515
    GO:0007179transforming growth factor beta receptor signaling pathway ----

    Find genes that share ontologies with NFIC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFIC

    7 Novoseek inferred chemical compound relationships for NFIC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diamide 43.7 3 9417094 (2), 7961993 (1)
    phosphoenolpyruvate 25.2 2 9593667 (1), 10085123 (1)
    gtp 4.01 2 9593667 (1), 10085123 (1)
    oxygen 0 1 14573596 (1)
    steroid 0 1 11463853 (1)
    zinc 0 1 11586467 (1)
    cysteine 0 6 9417094 (2), 7961993 (2)



    Find genes that share compounds with NFIC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NFIC gene (5 alternative transcripts): 
    NM_001245002.1  NM_001245004.1  NM_001245005.1  NM_005597.3  NM_205843.2  

    Unigene Cluster for NFIC:

    Nuclear factor I/C (CCAAT-binding transcription factor)
    Hs.170131  [show with all ESTs]
    Unigene Representative Sequence: NM_205843
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589123 ENST00000395111(uc010xhh.2) ENST00000586919 ENST00000341919(uc010xhj.2 uc002lxp.3)
    ENST00000590282 ENST00000443272(uc002lxo.3 uc010xhi.2) ENST00000588839
    ENST00000589537 ENST00000589164 ENST00000589969 ENST00000346156
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFIC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFIC (see all 9):
    hsa-miR-15a hsa-miR-497 hsa-miR-511 hsa-miR-424 hsa-miR-143 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidNFIC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFIC
    Predesigned siRNA for gene silencing in human, mouse, rat NFIC
    Clone
    Products:
         
    OriGene clones in human, mouse for NFIC (see all 14)
    OriGene ORF clones in mouse, rat for NFIC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NFIC (NM_005597)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFIC
    OriGene qSTAR qPCR primer pairs in human, mouse for NFIC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFIC
      QuantiTect SYBR Green Assays in human, mouse, rat NFIC
      QuantiFast Probe-based Assays in human, mouse, rat NFIC

    Additional mRNA sequence: 

    AK129956.1 AK289885.1 AK297825.1 AK297867.1 AK304816.1 BC012120.1 CR536507.1 X12492.1 
    X92857.1 

    18 DOTS entries:

    DT.75182618  DT.97844384  DT.40228616  DT.95170452  DT.95138503  DT.92338443  DT.100025803  DT.75103507 
    DT.91718672  DT.100810157  DT.97844385  DT.100773433  DT.95175535  DT.100746694  DT.100687788  DT.100044560 
    DT.121421550  DT.100810156 

    Selected AceView cDNA sequences (see all 430):

    BQ894051 BM712746 CR613340 BM678391 AW204440 CD675391 BM726430 AI687984 
    AI669442 CD672744 CD672536 BM681597 BP337273 BU527020 BF590561 CK431049 
    CA407589 NM_205843 AA648118 BF222078 BU177045 F11146 BU739957 BG171093 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NFIC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                                       
    SP2:                                -                       -     -         
    SP3:                                                        -     -         


    ECgene alternative splicing isoforms for NFIC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NFIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NFIC Expression
    About this image


    NFIC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    NFIC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFIC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170131
        Custom PCR Arrays for NFIC
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFIC
    OriGene qSTAR qPCR primer pairs in human, mouse for NFIC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFIC
    QuantiTect SYBR Green Assays in human, mouse, rat NFIC
    QuantiFast Probe-based Assays in human, mouse, rat NFIC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NFIC gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfic1 , 5 nuclear factor I/C1, 5 89.28(n)1
    96.45(a)1
      10 (39.72 cM)5
    180291  NM_008688.31  NP_032714.11 
     813961865 
    chicken
    (Gallus gallus)
    Aves NFIC1 nuclear factor I/C (CCAAT-binding transcription factor) 86.06(n)
    90.53(a)
      396208  NM_205271.1  NP_990602.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFIC6
    nuclear factor I/C (CCAAT-binding transcription fa...
    78(a)
    1 ↔ 1
    AAWZ02037457(7587-15315)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nfic1 nuclear factor I/C (CCAAT-binding transcription factor) 72.64(n)
    83.27(a)
      100491004  XM_004911032.1  XP_004911089.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000055681 novel protein similar to vertebrate nuclear factor more 77.36(n)
    85.06(a)
      100005568  XM_005166939.1  XP_005166996.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG23803 transcription factor 41(a)   102B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea nfi-13 Nuclear factor 1 54(a)   II(7534429-7542464)   --


    ENSEMBL Gene Tree for NFIC (if available)
    TreeFam Gene Tree for NFIC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NFIC gene
    NFIB2  NFIA2  NFIX2  
    5 SIMAP similar genes for NFIC using alignment to 2 protein entries:     NFIC_HUMAN (see all proteins):
    NFIX    NFIB    NFI    NFIA    DKFZp686I05275

    Find genes that share paralogs with NFIC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NFIC (see all 2624)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116694101,2
    H--3281884(+) attcaG/Ttttcc 2 -- us2k10--------
    rs735202891,2
    C,F--3282021(+) GGTGAG/AAGGCG 2 -- us2k12Minor allele frequency- A:0.04WA 120
    rs104022361,2
    C,F,A,H--3282126(+) TTCCCC/AGAGGC 2 -- us2k121Minor allele frequency- A:0.11NS EA NA WA CSA 2347
    rs1872893921,2
    --3282139(+) GGGAGC/TGGGTG 2 -- us2k10--------
    rs1482684661,2
    C--3282195(+) GAGGG-/GGGA  
            
    GGGAG
    2 -- us2k10--------
    rs803382651,2
    C--3282217(+) TAACCA/CACTAA 2 -- us2k10--------
    rs1457207121,2
    --3282221(+) CCACTA/GACCCT 2 -- us2k10--------
    rs1149718111,2
    F--3282334(+) ACCCCA/GGGTTG 2 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1920866711,2
    --3282343(+) TGACCC/TCTCTC 2 -- us2k10--------
    rs796194681,2
    C,F--3282368(+) TCCTTC/GTGAAC 2 -- us2k12Minor allele frequency- G:0.01WA NA 238

    HapMap Linkage Disequilibrium report for NFIC (3359561 - 3469215 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NFIC (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1167286CNV Deletion17803354
    esv2717945CNV Deletion23290073
    esv2671745CNV Deletion23128226
    nsv509717CNV Insertion20534489
    nsv833712CNV Loss17160897
    dgv3651n71CNV Loss21882294
    nsv910722CNV Loss21882294
    dgv3652n71CNV Loss21882294
    nsv470114CNV Loss18288195
    dgv3650n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFIC
    DNA2.0 Custom Variant and Variant Library Synthesis for NFIC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600729    OMIM disorders: --

    1 disease for NFIC:    
    About MalaCards
    common wart

    4 diseases from the University of Copenhagen DISEASES database for NFIC:
    Neurofibroma     Neurofibromatosis     maturity-onset diabetes of the young     Common wart

    Find genes that share disorders with NFIC           About GenesLikeMe

    Genetic Association Database (GAD): NFIC
    Human Genome Epidemiology (HuGE) Navigator: NFIC (3 documents)

    Export disorders for NFIC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NFIC gene, integrated from 10 sources (see all 141):
    (articles sorted by number of sources associating them with NFIC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. (PubMed id 3398920)1, 2, 3 Santoro C.... Tjian R. (Nature 1988)
    2. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PubMed id 7590749)1, 3, 9 Qian F.... Sippel A.E. (Genomics 1995)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. CTF5 -- a new transcriptional activator of the NFI/CTF family. (PubMed id 8710515)1, 2 Wenzelides S.... Winnacker E.L. (Nucleic Acids Res. 1996)
    9. Transcriptional regulation of the human alpha6 integrin gene by the transcription factor NFI during corneal wound healing. (PubMed id 18421093)1, 9 Gaudreault M....GuAcrin S.L. (amp 2008)
    10. CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription. (PubMed id 10085123)1, 9 Leahy P....Hanson R.W. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4782 HGNC: 7786 AceView: NFIC Ensembl:ENSG00000141905 euGenes: HUgn4782
    ECgene: NFIC H-InvDB: NFIC

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NFIC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NFIC gene:
    Search GeneIP for patents involving NFIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NFIC   OriGene RNAi products in human, mouse, rat for NFIC  
     OriGene qPCR primer pairs and template standards for NFIC   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for NFIC   OriGene clones in human, mouse for NFIC  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFIC   OriGene Purified Protein for NFIC  
     OriGene ORF clones in mouse, rat for NFIC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFIC   OriGene Custom Protein Services for NFIC  

     
     
     Block miRNA regulation of human, mouse, rat NFIC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NFIC
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFIC Predesigned siRNA for gene silencing in human, mouse, rat NFIC
     QuantiFast Probe-based Assays in human, mouse, rat NFIC QuantiTect SYBR Green Assays in human, mouse, rat NFIC
     Custom PCR Arrays for NFIC Search Chromatin IP Primers for NFIC
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFIC  GeneGlobe Interaction Network for NFIC
     Regulatory tfbs in NFIC promoter
     GenScript Custom Purified and Recombinant Proteins Services for NFIC GenScript cDNA clones with any tag delivered in your preferred vector for NFIC
     GenScript Custom Assay Services for NFIC GenScript Custom overexpressing Cell Line Services for NFIC
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for NFIC  (NFI-C)

     Search Tocris compounds for NFIC
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NFIC antibodies
     NFIC proteins
     NFIC lysates
     Antibodies for NFIC
     See all of Abcam's Antibodies, Kits and Proteins for NFIC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NFIC
     Antibodies for NFIC
     ELISAs for NFIC
     CLIAs for NFIC



     Browse ESI BIO Cell Lines and PureStem Progenitors for NFIC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIC
     SwitchGear 3'UTR luciferase reporter plasmids for NFIC
     SwitchGear Promoter luciferase reporter plasmids for NFIC
     ThermoFisher Antibodies for NFIC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIC
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFIC
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFIC
     LSBio Antibodies in human, mouse, rat for NFIC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NFIC
      Search eBioscience for proteins for NFIC
      Search eBioscience for elisas for NFIC
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFIC gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4