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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFIC Gene

protein-coding   GIFtS: 57
GCID: GC19P003310

nuclear factor I/C (CCAAT-binding transcription factor)


(Previous symbol: NFI)
 Explore 17 diseases affiliated with
NFIC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NFIC    

Aliases
for NFIC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Factor I/C (CCAAT-Binding Transcription Factor)1 2     CCAAT-Box-Binding Transcription Factor2 3
CTF1 2 3     TGGCA-Binding Protein2 3
NFI1 2 3     Nuclear Factor 1 C-Type2
CTF51 2     NFI-C3
NF-I1 2     Nuclear Factor 1/C3
NF-I/C2 3     Nuclear Factor I/C3
NF1-C2 3     

External Ids:    HGNC: 77861   Entrez Gene: 47822   Ensembl: ENSG000001419057   OMIM: 6007295   UniProtKB: P086513   

Export aliases for NFIC gene to outside databases

Previous GC identifers: GC19P003458 GC19P003306 GC19P003318 GC19P003319 GC19P003126


Summaries
for NFIC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NFIC:
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function
as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: NFIC_HUMAN, P08651
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters
and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating
transcription and replication

Gene Wiki entry for NFIC


Genomic Views
for NFIC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFIC gene promoter:
         GR   AP-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NFIC promoter sequence
   Search SABiosciences Chromatin IP Primers for NFIC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFIC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

NFIC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003310:  view genomic region     (about GC identifiers)

Start:
 3,359,561 bp from pter      End:
 3,469,215 bp from pter
Size:
 109,655 bases      Orientation:
 plus strand

Proteins
for NFIC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NFIC_HUMAN, P08651 (See protein sequence)
Recommended Name: Nuclear factor 1 C-type  
Size: 508 amino acids; 55675 Da
Subunit: Binds DNA as a homodimer
Subcellular location: Nucleus
Secondary accessions: A8K1H0 B7Z9C3 P08652 Q14932 Q9UPJ3 Q9UPJ9 Q9UPK0 Q9UPK1
Alternative splicing: 5 isoforms:  P08651-1   P08651-2   P08651-3   P08651-4   P08651-5   

Explore the universe of human proteins at neXtProt for NFIC: NX_P08651

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08651

    • NFIC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001231931.1  NP_001231933.1  NP_001231934.1  NP_005588.2  NP_995315.1  

    ENSEMBL proteins: 
     ENSP00000465655   ENSP00000378543   ENSP00000465177   ENSP00000342194   ENSP00000466647  
     ENSP00000396843   ENSP00000301935  

    Human Recombinant Protein Products: 
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    Novus Biologicals NFIC Proteins
    Novus Biologicals NFIC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NFIC

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    NFIC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NFIC

    Protein Domains /
    Families
    for NFIC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NFIC for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019548 CTF/NFI_DNA-bd_N
     IPR000647 CTF/NFI
     IPR019739 CTF/NFI_DNA-bd_CS
     IPR003619 MAD_homology1_Dwarfin-type
     IPR020604 CTF/NFI_DNA-bd-dom

    Graphical View of Domain Structure for InterPro Entry P08651

    ProtoNet protein and cluster: P08651

    2 Blocks protein families:
    IPB000647 CTF/NF-I family
    IPB009044 ssDNA-binding transcriptional regulator


    UniProtKB/Swiss-Prot: NFIC_HUMAN, P08651
    Similarity: Belongs to the CTF/NF-I family
    Similarity: Contains 1 CTF/NF-I DNA-binding domain


    Function
    for NFIC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NFIC_HUMAN, P08651
    Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters
    and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating
    transcription and replication

         Genatlas biochemistry entry for NFIC:
    nuclear transcription factor I C,DNA binding protein

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFIC
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIC (see all 9):
    hsa-miR-15a hsa-miR-497 hsa-miR-511 hsa-miR-424 hsa-miR-143 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmid: NFIC 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: NFIC
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIC 

    Cell Line
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    Search LifeMap BioReagents cell lines for NFIC

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA1524678


    NFIC for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NFIC:
     Big cells 

    Animal Models:
         Mouse knock-out Nfictm1Rmg for NFIC
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nfic):
     behavior/neurological  craniofacial  growth/size  mortality/aging  nervous system 
     reproductive system  skeleton 

    NFIC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NFIC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FOXA1 transcription factor network
    		FOXA1 transcription factor network1.00


    1 BioSystems Pathway for NFIC 
        FOXA1 transcription factor network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFIC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/599 Interacting proteins for NFIC (P086512, 3 ENSP000003968434) via UniProtKB, MINT, STRING, and/or I2D (see all 599)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TKTL2Q9H0I92, 3, ENSP000002806054MINT-67467 I2D: score=4 STRING: ENSP00000280605
    RBMXP381592, 3MINT-7945693 I2D: score=1 
    LLPHQ9BRT62, 3, ENSP000002666044MINT-66158 I2D: score=4 STRING: ENSP00000266604
    TPD52L3Q96J772, 3, ENSP000003416774MINT-66242 I2D: score=4 STRING: ENSP00000341677
    ZKSCAN7Q9P0L13, ENSP000002733204I2D: score=3 STRING: ENSP00000273320
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IGI1524678
    GO:0006260DNA replication IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS8710515
    GO:0042475odontogenesis of dentin-containing tooth ----


    NFIC for ontologies           About GeneDecksing



    Drugs & Compounds
    for NFIC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NFIC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFIC
    7 Novoseek chemical compound relationships for NFIC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diamide 43.7 3 9417094 (2), 7961993 (1)
    phosphoenolpyruvate 25.2 2 9593667 (1), 10085123 (1)
    gtp 4.01 2 9593667 (1), 10085123 (1)
    oxygen 0 1 14573596 (1)
    steroid 0 1 11463853 (1)
    zinc 0 1 11586467 (1)
    cysteine 0 6 9417094 (2), 7961993 (2)

    Search CenterWatch for drugs/clinical trials and news about NFIC 

    Transcripts
    for NFIC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NFIC gene (5 alternative transcripts): 
    NM_001245002.1  NM_001245004.1  NM_001245005.1  NM_005597.3  NM_205843.2  

    Unigene Cluster for NFIC:

    Nuclear factor I/C (CCAAT-binding transcription factor)
    Hs.170131  [show with all ESTs]
    Unigene Representative Sequence: NM_205843
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589123 ENST00000395111(uc010xhh.2) ENST00000586919 ENST00000341919(uc010xhj.2 uc002lxp.3)
    ENST00000590282 ENST00000443272(uc002lxo.3 uc010xhi.2) ENST00000588839
    ENST00000589537 ENST00000589164 ENST00000589969 ENST00000346156

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFIC
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIC (see all 9):
    hsa-miR-15a hsa-miR-497 hsa-miR-511 hsa-miR-424 hsa-miR-143 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmid: NFIC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFIC (see all 7)
    OriGene siRNA: NFIC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFIC
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): NFIC (NM_005597)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIC 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFIC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFIC

    Additional cDNA sequence: 

    AK129956.1 AK289885.1 AK297825.1 AK297867.1 AK304816.1 BC012120.1 CR536507.1 X12492.1 
    X92857.1 

    18 DOTS entries:

    DT.75182618  DT.97844384  DT.40228616  DT.95170452  DT.95138503  DT.92338443  DT.100025803  DT.75103507 
    DT.91718672  DT.100810157  DT.97844385  DT.100773433  DT.95175535  DT.100746694  DT.100687788  DT.100044560 
    DT.121421550  DT.100810156 

    24/430 AceView cDNA sequences (see all 430):

    AI659623 BM462015 BQ949936 BE875949 BQ925590 BM685454 CR536507 BF725593 
    BM845871 BF002952 BE733557 CD675038 BI087281 AL135598 AL042511 BM721877 
    AW071957 BQ020355 T29831 CD722455 BE563136 F26775 NM_005597 BM753510 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NFIC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                                       
    SP2:                                -                       -     -         
    SP3:                                                        -     -         


    ECgene alternative splicing isoforms for NFIC

    Expression
    for NFIC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFIC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NFIC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    BoneMaxillary ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NFIC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFIC

    SOURCE GeneReport for Unigene cluster: Hs.170131
        SABiosciences Custom PCR Arrays for NFIC
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIC

    Orthologs
    for NFIC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NFIC gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NFIC1 nuclear factor I/C (CCAAT-binding transcription factor) 85.98(n)
    90.34(a)    		   396208  NM_205271.1  NP_990602.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NFIC6
    		 --
    		 81(a)
    		 1 ↔ 1
    		 AAWZ02037457(7587-15315)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000055681 novel protein similar to vertebrate nuclear factor more 77.1(n)
    84.25(a)    		   100005568  XM_001921127.1  XP_001921162.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG23803 transcription factor 41(a)   102B3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea nfi-13 Nuclear factor 1 54(a)   II(7534429-7542464)   --


    ENSEMBL Gene Tree for NFIC (if available)
    TreeFam Gene Tree for NFIC (if available) 

    Paralogs
    for NFIC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFIC gene
    NFIB2  NFIA2  NFIX2  
    6 SIMAP similar genes for NFIC using alignment to 3 protein entries:     NFIC_HUMAN (see all proteins):
    NFIX    NFIB    NFI    NFIA    DKFZp686E13259    DKFZp686I05275

    NFIC for paralogs           About GeneDecksing



    Genomic Variants
    for NFIC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2109 NCBI SNPs in NFIC are shown (see all 2109)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs735202891,2
    		C,--3357675(+) GGTGAG/AAGGCG 2 -- us2k12Minor allele frequency- A:0.04WA 120
    rs104022361,2
    		C,F,A,H,--3357780(+) TTCCCC/AGAGGC 2 -- us2k121Minor allele frequency- A:0.11NS EA NA WA CSA 2347
    rs1872893921,2
    		--3357793(+) GGGAGC/TGGGTG 2 -- us2k10--------
    rs1482684661,2
    		C,--3357849(+) GAGGG-/GGGA  
                GGGAG     		2 -- us2k10--------
    rs1429936661,2
    		C,--3357854(+) GGGAG-/GGAGGGGG 2 -- us2k10--------
    rs803382651,2
    		C,--3357875(+) TAACCA/CACTAA 2 -- us2k10--------
    rs1457207121,2
    		--3357879(+) CCACTA/GACCCT 2 -- us2k10--------
    rs1149718111,2
    		F,--3357992(+) ACCCCA/GGGTTG 2 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1920866711,2
    		--3358001(+) TGACCC/TCTCTC 2 -- us2k10--------
    rs796194681,2
    		F,--3358026(+) TCCTTC/GTGAAC 2 -- us2k12Minor allele frequency- G:0.01WA NA 238

    HapMap Linkage Disequilibrium report for NFIC (3359561 - 3469215 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for NFIC
         4 CNVs: 30067 30066 5072 30068
         1 Indel: 26251

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    Disorders / Diseases
    for NFIC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NFIC for disorders           About GeneDecksing

    OMIM gene information: 600729    OMIM disorders: --

    17 diseases for NFIC:    About MalaCards
    colorado tick fever    progressive multifocal leukoencephalopathy    maturity-onset diabetes of the young    epidermodysplasia verruciformis
    common wart    polycystic ovary syndrome    astigmatism    malignant glioma
    leprosy    neurofibromatosis    t-cell leukemia    pharyngitis
    leukemia    melanoma    hepatitis    neuronitis
    alcoholism

    4 diseases from the University of Copenhagen DISEASES database for NFIC:
    Neurofibroma     Neurofibromatosis     maturity-onset diabetes of the young     Common wart
    Human Genome Epidemiology (HuGE) Navigator: NFIC (3 documents)

    Export disorders for NFIC gene to outside databases

    Publications
    for NFIC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFIC gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with NFIC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. (PubMed id 3398920)1, 2, 3 Santoro C.... Tjian R. (1988)
    2. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PubMed id 7590749)1, 3, 9 Qian F....Sippel A.E. (1995)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. CTF5 -- a new transcriptional activator of the NFI/CTF family. (PubMed id 8710515)1, 2 Wenzelides S.... Winnacker E.L. (1996)
    7. Transcriptional regulation of the human alpha6 integrin gene by the transcription factor NFI during corneal wound healing. (PubMed id 18421093)1, 9 Gaudreault M....Guerin S.L. (2008)
    8. CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription. (PubMed id 10085123)1, 9 Leahy P....Hanson R.W. (1999)
    9. Thioltransferase (glutaredoxin) reactivates the DNA-binding activity of oxidation-inactivated nuclear factor I. (PubMed id 9417094)1, 9 Bandyopadhyay S....Gronostajski R.M. (1998)
    10. Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins. (PubMed id 7961993)1, 9 Bandyopadhyay S. and Gronostajski R.M. (1994)

    External Searches for NFIC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NFIC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4782 HGNC: 7786 AceView: NFIC Ensembl:ENSG00000141905 euGenes: HUgn4782
    ECgene: NFIC H-InvDB: NFIC

    Other Databases showing NFIC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NFIC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFIC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NFIC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFIC gene:
    Search GeneIP for patents involving NFIC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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