Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NFIC Gene

Aliases for NFIC Gene

  • Nuclear Factor I C 2 3
  • Nuclear Factor I/C (CCAAT-Binding Transcription Factor) 2 3 5
  • CCAAT-Box-Binding Transcription Factor 3 4
  • TGGCA-Binding Protein 3 4
  • NF-I/C 3 4
  • NF1-C 3 4
  • CTF 3 4
  • NFI 3 4
  • CCAAT-Binding Transcription Factor 2
  • Nuclear Factor 1/C 4
  • Nuclear Factor I/C 4
  • NFI-C 4
  • CTF5 3
  • NF-I 3

External Ids for NFIC Gene

Previous HGNC Symbols for NFIC Gene

  • NFI

Previous GeneCards Identifiers for NFIC Gene

  • GC19P003458
  • GC19P003306
  • GC19P003318
  • GC19P003319
  • GC19P003310
  • GC19P003126

Summaries for NFIC Gene

Entrez Gene Summary for NFIC Gene

  • The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NFIC Gene

NFIC (Nuclear Factor I C) is a Protein Coding gene. Among its related pathways are Gene Expression and FOXA1 transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NFIX.

UniProtKB/Swiss-Prot for NFIC Gene

  • Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene Wiki entry for NFIC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFIC Gene

Genomics for NFIC Gene

Regulatory Elements for NFIC Gene

Promoters for NFIC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NFIC on UCSC Golden Path with GeneCards custom track

Genomic Location for NFIC Gene

Chromosome:
19
Start:
3,359,563 bp from pter
End:
3,469,217 bp from pter
Size:
109,655 bases
Orientation:
Plus strand

Genomic View for NFIC Gene

Genes around NFIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFIC Gene

Proteins for NFIC Gene

  • Protein details for NFIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08651-NFIC_HUMAN
    Recommended name:
    Nuclear factor 1 C-type
    Protein Accession:
    P08651
    Secondary Accessions:
    • A8K1H0
    • B7Z4U5
    • B7Z9C3
    • K7EMU1
    • P08652
    • Q14932
    • Q9UPJ3
    • Q9UPJ9
    • Q9UPK0
    • Q9UPK1

    Protein attributes for NFIC Gene

    Size:
    508 amino acids
    Molecular mass:
    55675 Da
    Quaternary structure:
    • Binds DNA as a homodimer.

    Alternative splice isoforms for NFIC Gene

neXtProt entry for NFIC Gene

Proteomics data for NFIC Gene at MOPED

Post-translational modifications for NFIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NFIC (NFI-C)

No data available for DME Specific Peptides for NFIC Gene

Domains & Families for NFIC Gene

Suggested Antigen Peptide Sequences for NFIC Gene

Graphical View of Domain Structure for InterPro Entry

P08651

UniProtKB/Swiss-Prot:

NFIC_HUMAN :
  • Contains 1 CTF/NF-I DNA-binding domain.
  • Belongs to the CTF/NF-I family.
Domain:
  • Contains 1 CTF/NF-I DNA-binding domain.
Family:
  • Belongs to the CTF/NF-I family.
genes like me logo Genes that share domains with NFIC: view

No data available for Gene Families for NFIC Gene

Function for NFIC Gene

Molecular function for NFIC Gene

GENATLAS Biochemistry:
nuclear transcription factor I C,DNA binding protein
UniProtKB/Swiss-Prot Function:
Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene Ontology (GO) - Molecular Function for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 1524678
GO:0001159 core promoter proximal region DNA binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with NFIC: view
genes like me logo Genes that share phenotypes with NFIC: view

Animal Models for NFIC Gene

MGI Knock Outs for NFIC:

Animal Model Products

miRNA for NFIC Gene

miRTarBase miRNAs that target NFIC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFIC Gene

Localization for NFIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFIC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFIC Gene COMPARTMENTS Subcellular localization image for NFIC gene
Compartment Confidence
nucleus 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for NFIC Gene

Pathways & Interactions for NFIC Gene

genes like me logo Genes that share pathways with NFIC: view

Gene Ontology (GO) - Biological Process for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042475 odontogenesis of dentin-containing tooth IEA --
genes like me logo Genes that share ontologies with NFIC: view

No data available for SIGNOR curated interactions for NFIC Gene

Drugs & Compounds for NFIC Gene

(3) Drugs for NFIC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for NFIC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NFIC: view

Transcripts for NFIC Gene

Unigene Clusters for NFIC Gene

Nuclear factor I/C (CCAAT-binding transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFIC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for NFIC Gene

GeneLoc Exon Structure for
NFIC
ECgene alternative splicing isoforms for
NFIC

Expression for NFIC Gene

mRNA expression in normal human tissues for NFIC Gene

mRNA differential expression in normal tissues according to GTEx for NFIC Gene

This gene is overexpressed in Muscle - Skeletal (x4.9).

Protein differential expression in normal tissues from HIPED for NFIC Gene

This gene is overexpressed in Ovary (12.0) and Fetal testis (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFIC Gene



SOURCE GeneReport for Unigene cluster for NFIC Gene Hs.170131

genes like me logo Genes that share expression patterns with NFIC: view

Protein tissue co-expression partners for NFIC Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NFIC Gene

Orthologs for NFIC Gene

This gene was present in the common ancestor of animals.

Orthologs for NFIC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFIC 35
  • 93.07 (n)
  • 99.05 (a)
NFIC 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFIC 35
  • 94.14 (n)
  • 98.22 (a)
NFIC 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfic 35
  • 89.28 (n)
  • 96.45 (a)
Nfic 16
Nfic 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfic 35
  • 89.6 (n)
  • 96.93 (a)
oppossum
(Monodelphis domestica)
Mammalia NFIC 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFIC 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFIC 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFIC 35
  • 86.06 (n)
  • 90.53 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NFIC 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfic 35
  • 72.64 (n)
  • 83.27 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005568 35
  • 77.36 (n)
  • 85.06 (a)
nfic 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2380 37
  • 41 (a)
NfI 36
  • 29 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta NFI 35
  • 68.4 (n)
  • 65.1 (a)
worm
(Caenorhabditis elegans)
Secernentea nfi-1 37
  • 54 (a)
nfi-1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for NFIC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFIC Gene

ENSEMBL:
Gene Tree for NFIC (if available)
TreeFam:
Gene Tree for NFIC (if available)

Paralogs for NFIC Gene

Paralogs for NFIC Gene

(5) SIMAP similar genes for NFIC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFIC: view

Variants for NFIC Gene

Sequence variations from dbSNP and Humsavar for NFIC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10412720 - 3,452,646(+) ACCCA(A/G/T)CCAGC reference, missense
rs8047 -- 3,462,851(+) GTTTT(A/C/G/T)GGTGG reference, missense, utr-variant-3-prime
rs740521 -- 3,367,747(-) CTCTC(C/T)AGAAC intron-variant
rs758257 -- 3,364,190(+) GTGCT(C/G)GAAAG intron-variant
rs758258 -- 3,364,440(+) AGCCC(A/G)CGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFIC Gene

Variant ID Type Subtype PubMed ID
nsv833712 CNV Loss 17160897
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
nsv509717 CNV Insertion 20534489
dgv3650n71 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
esv2717945 CNV Deletion 23290073
esv2671745 CNV Deletion 23128226
esv1167286 CNV Deletion 17803354
dgv3653n71 CNV Loss 21882294
nsv910738 CNV Loss 21882294
nsv526602 CNV Loss 19592680

Variation tolerance for NFIC Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFIC Gene

HapMap Linkage Disequilibrium report
NFIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFIC Gene

Disorders for NFIC Gene

Relevant External Links for NFIC

Genetic Association Database (GAD)
NFIC
Human Genome Epidemiology (HuGE) Navigator
NFIC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFIC

No disorders were found for NFIC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFIC Gene

Publications for NFIC Gene

  1. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. (PMID: 3398920) Santoro C. … Tjian R. (Nature 1988) 2 3 4 67
  2. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PMID: 7590749) Qian F. … Sippel A.E. (Genomics 1995) 2 3 23
  3. Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts. (PMID: 18809517) PAcrez-Casellas L.A. … Linkhart T.A. (Biochim. Biophys. Acta 2009) 3 23
  4. Transcriptional regulation of the human alpha6 integrin gene by the transcription factor NFI during corneal wound healing. (PMID: 18421093) Gaudreault M. … GuAcrin S.L. (Invest. Ophthalmol. Vis. Sci. 2008) 3 23
  5. Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1. (PMID: 14684846) Wickenheisser J.K. … McAllister J.M. (Mol. Endocrinol. 2004) 3 23

Products for NFIC Gene

Sources for NFIC Gene

Back to Top

Content