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Aliases for NFIC Gene

Aliases for NFIC Gene

  • Nuclear Factor I/C (CCAAT-Binding Transcription Factor) 2 3
  • CCAAT-Box-Binding Transcription Factor 3 4
  • TGGCA-Binding Protein 3 4
  • NF-I/C 3 4
  • NF1-C 3 4
  • CTF 3 4
  • NFI 3 4
  • Nuclear Factor 1 C-Type 3
  • Nuclear Factor 1/C 4
  • Nuclear Factor I/C 4
  • NFI-C 4
  • CTF5 3
  • NF-I 3

External Ids for NFIC Gene

Previous HGNC Symbols for NFIC Gene

  • NFI

Previous GeneCards Identifiers for NFIC Gene

  • GC19P003458
  • GC19P003306
  • GC19P003318
  • GC19P003319
  • GC19P003310
  • GC19P003126

Summaries for NFIC Gene

Entrez Gene Summary for NFIC Gene

  • The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NFIC Gene

NFIC (Nuclear Factor I/C (CCAAT-Binding Transcription Factor)) is a Protein Coding gene. Diseases associated with NFIC include common wart. Among its related pathways are Gene Expression and FOXA1 transcription factor network. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFIX.

UniProtKB/Swiss-Prot for NFIC Gene

  • Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication

Gene Wiki entry for NFIC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFIC Gene

Genomics for NFIC Gene

Regulatory Elements for NFIC Gene

Genomic Location for NFIC Gene

Start:
3,359,563 bp from pter
End:
3,469,217 bp from pter
Size:
109,655 bases
Orientation:
Plus strand

Genomic View for NFIC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFIC Gene

Proteins for NFIC Gene

  • Protein details for NFIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08651-NFIC_HUMAN
    Recommended name:
    Nuclear factor 1 C-type
    Protein Accession:
    P08651
    Secondary Accessions:
    • A8K1H0
    • B7Z4U5
    • B7Z9C3
    • K7EMU1
    • P08652
    • Q14932
    • Q9UPJ3
    • Q9UPJ9
    • Q9UPK0
    • Q9UPK1

    Protein attributes for NFIC Gene

    Size:
    508 amino acids
    Molecular mass:
    55675 Da
    Quaternary structure:
    • Binds DNA as a homodimer

    Alternative splice isoforms for NFIC Gene

neXtProt entry for NFIC Gene

Proteomics data for NFIC Gene at MOPED

Post-translational modifications for NFIC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFIC Gene

No data available for DME Specific Peptides for NFIC Gene

Domains for NFIC Gene

Suggested Antigen Peptide Sequences for NFIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08651

UniProtKB/Swiss-Prot:

NFIC_HUMAN :
  • P08651
Domain:
  • Contains 1 CTF/NF-I DNA-binding domain.
Family:
  • Belongs to the CTF/NF-I family.
genes like me logo Genes that share domains with NFIC: view

No data available for Gene Families for NFIC Gene

Function for NFIC Gene

Molecular function for NFIC Gene

GENATLAS Biochemistry: nuclear transcription factor I C,DNA binding protein
UniProtKB/Swiss-Prot Function: Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication

Gene Ontology (GO) - Molecular Function for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 1524678
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 1524678
GO:0001159 core promoter proximal region DNA binding --
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with NFIC: view
genes like me logo Genes that share phenotypes with NFIC: view

Animal Models for NFIC Gene

MGI Knock Outs for NFIC:

miRNA for NFIC Gene

miRTarBase miRNAs that target NFIC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NFIC Gene

Localization for NFIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFIC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFIC Gene COMPARTMENTS Subcellular localization image for NFIC gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with NFIC: view

Pathways for NFIC Gene

genes like me logo Genes that share pathways with NFIC: view

Gene Ontology (GO) - Biological Process for NFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IGI 1524678
GO:0006260 DNA replication IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 8710515
GO:0007179 transforming growth factor beta receptor signaling pathway --
genes like me logo Genes that share ontologies with NFIC: view

Compounds for NFIC Gene

(7) Novoseek inferred chemical compound relationships for NFIC Gene

Compound -log(P) Hits PubMed IDs
diamide 43.7 3
phosphoenolpyruvate 25.2 2
gtp 4.01 2
oxygen 0 1
steroid 0 1
genes like me logo Genes that share compounds with NFIC: view

Transcripts for NFIC Gene

Unigene Clusters for NFIC Gene

Nuclear factor I/C (CCAAT-binding transcription factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFIC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for NFIC Gene

GeneLoc Exon Structure for
NFIC
ECgene alternative splicing isoforms for
NFIC

Expression for NFIC Gene

mRNA expression in normal human tissues for NFIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFIC Gene

This gene is overexpressed in Muscle - Skeletal (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFIC Gene

SOURCE GeneReport for Unigene cluster for NFIC Gene Hs.170131

genes like me logo Genes that share expressions with NFIC: view

No data available for mRNA Expression by UniProt/SwissProt for NFIC Gene

Orthologs for NFIC Gene

This gene was present in the common ancestor of animals.

Orthologs for NFIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFIC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFIC 35
  • 93.07 (n)
  • 99.05 (a)
NFIC 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFIC 35
  • 94.14 (n)
  • 98.22 (a)
NFIC 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfic 35
  • 89.28 (n)
  • 96.45 (a)
Nfic 16
Nfic 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFIC 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFIC 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfic 35
  • 89.6 (n)
  • 96.93 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 94 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
NFIC 35
  • 86.06 (n)
  • 90.53 (a)
lizard
(Anolis carolinensis)
Reptilia NFIC 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfic 35
  • 72.64 (n)
  • 83.27 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005568 35
  • 77.36 (n)
  • 85.06 (a)
nfic 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NFI 35
  • 68.4 (n)
  • 65.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta NfI 36
  • 29 (a)
OneToMany
CG2380 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea nfi-1 36
  • 21 (a)
OneToMany
nfi-1 37
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for NFIC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NFIC Gene

ENSEMBL:
Gene Tree for NFIC (if available)
TreeFam:
Gene Tree for NFIC (if available)

Paralogs for NFIC Gene

Paralogs for NFIC Gene

Selected SIMAP similar genes for NFIC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFIC: view

Variants for NFIC Gene

Sequence variations from dbSNP and Humsavar for NFIC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8047 -- 3,462,851(+) GTTTT(A/C/G/T)GGTGG utr-variant-3-prime, stop-gained, reference, missense
rs713043 -- 3,465,120(+) CCTGT(C/T)CCTCG utr-variant-3-prime
rs718202 -- 3,374,704(+) TTCAG(C/T)ATCTA intron-variant
rs731483 -- 3,385,506(+) TCCTC(G/T)TCGGG intron-variant
rs740521 -- 3,367,747(-) CTCTC(C/T)AGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFIC Gene

Variant ID Type Subtype PubMed ID
nsv833712 CNV Loss 17160897
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
nsv509717 CNV Insertion 20534489
dgv3650n71 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
esv2717945 CNV Deletion 23290073
esv2671745 CNV Deletion 23128226
esv1167286 CNV Deletion 17803354
dgv3653n71 CNV Loss 21882294
nsv910738 CNV Loss 21882294
nsv526602 CNV Loss 19592680

Relevant External Links for NFIC Gene

HapMap Linkage Disequilibrium report
NFIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFIC Gene

Disorders for NFIC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NFIC Gene including...

Search for NFIC Gene in MalaCards »

Relevant External Links for NFIC

Genetic Association Database (GAD)
NFIC
Human Genome Epidemiology (HuGE) Navigator
NFIC
genes like me logo Genes that share disorders with NFIC: view

No data available for UniProtKB/Swiss-Prot for NFIC Gene

Publications for NFIC Gene

  1. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PMID: 7590749) Qian F. … Sippel A.E. (Genomics 1995) 2 3 23
  2. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. (PMID: 3398920) Santoro C. … Tjian R. (Nature 1988) 2 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for NFIC Gene

Sources for NFIC Gene

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