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Aliases for NFIB Gene

Aliases for NFIB Gene

  • Nuclear Factor I B 2 3 5
  • CCAAT-Box-Binding Transcription Factor 3 4
  • TGGCA-Binding Protein 3 4
  • Nuclear Factor I/B 2 4
  • Nuclear Factor 1/B 3 4
  • NF-I/B 3 4
  • NF1-B 3 4
  • NFI-B 3 4
  • CTF 3 4
  • Nuclear Factor 1 B-Type 3
  • HMGIC/NFIB 3
  • NFI-RED 3
  • NFIB2 3
  • NFIB3 3

External Ids for NFIB Gene

Previous GeneCards Identifiers for NFIB Gene

  • GC09M014252
  • GC09M014068

Summaries for NFIB Gene

GeneCards Summary for NFIB Gene

NFIB (Nuclear Factor I B) is a Protein Coding gene. Diseases associated with NFIB include Infiltrating Lipoma and Lipoma Of Colon. Among its related pathways are RNA Polymerase III Transcription Initiation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NFIA.

UniProtKB/Swiss-Prot for NFIB Gene

  • Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene Wiki entry for NFIB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFIB Gene

Genomics for NFIB Gene

Regulatory Elements for NFIB Gene

Enhancers for NFIB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F014306 2.8 FANTOM5 Ensembl ENCODE 12.5 +83.7 83686 18.3 PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF302 ZNF143 KLF13 NFIB ZDHHC21 GC09P014316 GC09P014255
GH09F014342 1.5 FANTOM5 Ensembl ENCODE 19.2 +50.5 50456 11.4 ATF1 CREB3L1 SIN3A RAD21 ZNF48 ZNF335 ZNF366 ZNF143 CREM MIXL1 NFIB ENSG00000225472 ZDHHC21 GC09P014354
GH09F014270 2.2 Ensembl ENCODE 11.4 +124.1 124105 9.3 INSM2 FEZF1 ZNF2 RAD21 ZEB1 GLIS2 ZNF366 FOS ZNF202 ZNF362 ENSG00000225472 NFIB GC09P014255 GC09P014316
GH09F014372 1.1 Ensembl ENCODE 11.9 +25.5 25501 2.2 ESRRA TEAD4 JUN TEAD3 FOSL1 CTBP1 ZBTB48 ZNF366 RCOR1 FOS NFIB GC09P014354
GH09F014153 1.2 Ensembl ENCODE 10.6 +245.5 245533 0.6 PKNOX1 INSM2 FEZF1 ZNF2 ZEB1 ZNF335 ZNF366 KLF7 OVOL3 TSHZ1 ENSG00000225472 NFIB RPL7AP47 GC09P014098
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFIB on UCSC Golden Path with GeneCards custom track

Genomic Location for NFIB Gene

Chromosome:
9
Start:
14,081,843 bp from pter
End:
14,398,983 bp from pter
Size:
317,141 bases
Orientation:
Minus strand

Genomic View for NFIB Gene

Genes around NFIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFIB Gene

Proteins for NFIB Gene

  • Protein details for NFIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00712-NFIB_HUMAN
    Recommended name:
    Nuclear factor 1 B-type
    Protein Accession:
    O00712
    Secondary Accessions:
    • G3V1P1
    • H7BYE8
    • O00166
    • Q12858
    • Q5VW29
    • Q63HM5
    • Q6ZNF9
    • Q96J45

    Protein attributes for NFIB Gene

    Size:
    420 amino acids
    Molecular mass:
    47442 Da
    Quaternary structure:
    • Binds DNA as a homodimer.

    Alternative splice isoforms for NFIB Gene

neXtProt entry for NFIB Gene

Post-translational modifications for NFIB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NFIB Gene

Domains & Families for NFIB Gene

Graphical View of Domain Structure for InterPro Entry

O00712

UniProtKB/Swiss-Prot:

NFIB_HUMAN :
  • Contains 1 CTF/NF-I DNA-binding domain.
  • Belongs to the CTF/NF-I family.
Domain:
  • Contains 1 CTF/NF-I DNA-binding domain.
Family:
  • Belongs to the CTF/NF-I family.
genes like me logo Genes that share domains with NFIB: view

No data available for Gene Families for NFIB Gene

Function for NFIB Gene

Molecular function for NFIB Gene

GENATLAS Biochemistry:
nuclear transcription factor I B,DNA binding protein
UniProtKB/Swiss-Prot Function:
Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene Ontology (GO) - Molecular Function for NFIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19540848
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 9099724
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19540848
GO:0003677 DNA binding IEA,IDA 9099724
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with NFIB: view
genes like me logo Genes that share phenotypes with NFIB: view

Animal Models for NFIB Gene

MGI Knock Outs for NFIB:

Animal Model Products

miRNA for NFIB Gene

miRTarBase miRNAs that target NFIB
Targeted motifs for NFIB Gene
HOMER Transcription Factor Regulatory Elements motif NFIB
  • Consensus sequence: CTTGGCACNGTGCCAA Submotif: canonical Cell Type: LNCAP

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NFIB Gene

Localization for NFIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFIB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFIB gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NFIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 9099724
GO:0005730 nucleolus IDA --
GO:0044300 cerebellar mossy fiber ISS --
genes like me logo Genes that share ontologies with NFIB: view

Pathways & Interactions for NFIB Gene

genes like me logo Genes that share pathways with NFIB: view

SIGNOR curated interactions for NFIB Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NFIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation ISS --
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with NFIB: view

Transcripts for NFIB Gene

Unigene Clusters for NFIB Gene

Nuclear factor I/B:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFIB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: - -

Relevant External Links for NFIB Gene

GeneLoc Exon Structure for
NFIB
ECgene alternative splicing isoforms for
NFIB

Expression for NFIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NFIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NFIB Gene

This gene is overexpressed in Heart (20.1), Fetal Brain (12.8), and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFIB Gene



Protein tissue co-expression partners for NFIB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFIB Gene:

NFIB

SOURCE GeneReport for Unigene cluster for NFIB Gene:

Hs.644095
genes like me logo Genes that share expression patterns with NFIB: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFIB Gene

Orthologs for NFIB Gene

This gene was present in the common ancestor of animals.

Orthologs for NFIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFIB 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia NFIB 34 35
  • 97.07 (n)
rat
(Rattus norvegicus)
Mammalia Nfib 34
  • 94.87 (n)
mouse
(Mus musculus)
Mammalia Nfib 34 16 35
  • 94.27 (n)
oppossum
(Monodelphis domestica)
Mammalia NFIB 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFIB 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFIB 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFIB 34 35
  • 91.6 (n)
lizard
(Anolis carolinensis)
Reptilia NFIB 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfib 34
  • 84.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2380 36
  • 75 (a)
NfI 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nfi-1 36 35
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for NFIB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NFIB Gene

ENSEMBL:
Gene Tree for NFIB (if available)
TreeFam:
Gene Tree for NFIB (if available)

Paralogs for NFIB Gene

Paralogs for NFIB Gene

genes like me logo Genes that share paralogs with NFIB: view

Variants for NFIB Gene

Sequence variations from dbSNP and Humsavar for NFIB Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1010335 -- 14,400,312(+) CAGAA(A/T)CGATG upstream-variant-2KB
rs10114590 -- 14,156,429(+) ACAGC(A/C)AATAC intron-variant
rs10114939 -- 14,135,400(+) AACAT(C/T)TGCAA intron-variant
rs10115333 -- 14,345,903(+) CTCCT(C/T)GGGTG intron-variant
rs10115397 -- 14,215,032(+) TTTCA(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFIB Gene

Variant ID Type Subtype PubMed ID
nsv972651 CNV duplication 23825009
nsv950839 CNV deletion 24416366
nsv950837 CNV deletion 24416366
nsv831516 CNV loss 17160897
nsv528796 CNV loss 19592680
nsv526315 CNV loss 19592680
nsv478666 CNV novel sequence insertion 20440878
nsv477288 CNV novel sequence insertion 20440878
nsv474265 CNV novel sequence insertion 20440878
nsv1144248 CNV deletion 24896259
nsv1137629 CNV deletion 24896259
nsv1076137 CNV deletion 25765185
nsv1033764 CNV loss 25217958
nsv1020298 CNV loss 25217958
esv991653 OTHER inversion 20482838
esv6710 CNV gain 19470904
esv3619750 CNV loss 21293372
esv3544575 CNV deletion 23714750
esv2738224 CNV deletion 23290073
esv2738223 CNV deletion 23290073
esv2738222 CNV deletion 23290073
esv2738221 CNV deletion 23290073
esv2738220 CNV deletion 23290073
esv2673979 CNV deletion 23128226
esv2669830 CNV deletion 23128226
dgv480n21 CNV loss 19592680

Variation tolerance for NFIB Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFIB Gene

Human Gene Mutation Database (HGMD)
NFIB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFIB Gene

Disorders for NFIB Gene

MalaCards: The human disease database

(9) MalaCards diseases for NFIB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
infiltrating lipoma
  • intramuscular lipoma
large intestine lipoma
  • lipoma of large intestine
lipoma of colon
  • colonic lipoma
pulmonary neuroendocrine tumor
  • neuroendocrine neoplasm of lung
breast adenoid cystic carcinoma
  • adenoid cystic carcinoma of breast
- elite association - COSMIC cancer census association via MalaCards
Search NFIB in MalaCards View complete list of genes associated with diseases

Relevant External Links for NFIB

Genetic Association Database (GAD)
NFIB
Human Genome Epidemiology (HuGE) Navigator
NFIB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFIB
genes like me logo Genes that share disorders with NFIB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFIB Gene

Publications for NFIB Gene

  1. NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. (PMID: 9099724) Liu Y. … Apt D. (J. Biol. Chem. 1997) 3 4 22 64
  2. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PMID: 7590749) Qian F. … Sippel A.E. (Genomics 1995) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. (PMID: 17511965) Mukhopadhyay S.S. … Rosen J.M. (Biochem. Biophys. Res. Commun. 2007) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NFIB Gene

Sources for NFIB Gene

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