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Aliases for NFIB Gene

Aliases for NFIB Gene

  • Nuclear Factor I/B 2 3 4
  • CCAAT-Box-Binding Transcription Factor 3 4
  • TGGCA-Binding Protein 3 4
  • Nuclear Factor 1/B 3 4
  • NF-I/B 3 4
  • NF1-B 3 4
  • NFI-B 3 4
  • CTF 3 4
  • Nuclear Factor 1 B-Type 3
  • HMGIC/NFIB 3
  • NFI-RED 3
  • NFIB2 3
  • NFIB3 3

External Ids for NFIB Gene

Previous GeneCards Identifiers for NFIB Gene

  • GC09M014252
  • GC09M014068

Summaries for NFIB Gene

GeneCards Summary for NFIB Gene

NFIB (Nuclear Factor I/B) is a Protein Coding gene. Diseases associated with NFIB include lipoma of colon and polymorphous low-grade adenocarcinoma. Among its related pathways are Gene Expression and FOXA1 transcription factor network. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and RNA polymerase II transcription corepressor activity. An important paralog of this gene is NFIX.

UniProtKB/Swiss-Prot for NFIB Gene

  • Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication

Gene Wiki entry for NFIB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFIB Gene

Genomics for NFIB Gene

Regulatory Elements for NFIB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFIB Gene

Start:
14,081,843 bp from pter
End:
14,398,983 bp from pter
Size:
317,141 bases
Orientation:
Minus strand

Genomic View for NFIB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFIB Gene

Proteins for NFIB Gene

  • Protein details for NFIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00712-NFIB_HUMAN
    Recommended name:
    Nuclear factor 1 B-type
    Protein Accession:
    O00712
    Secondary Accessions:
    • G3V1P1
    • H7BYE8
    • O00166
    • Q12858
    • Q5VW29
    • Q63HM5
    • Q6ZNF9
    • Q96J45

    Protein attributes for NFIB Gene

    Size:
    420 amino acids
    Molecular mass:
    47442 Da
    Quaternary structure:
    • Binds DNA as a homodimer

    Alternative splice isoforms for NFIB Gene

neXtProt entry for NFIB Gene

Proteomics data for NFIB Gene at MOPED

Post-translational modifications for NFIB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NFIB Gene

Domains for NFIB Gene

Graphical View of Domain Structure for InterPro Entry

O00712

UniProtKB/Swiss-Prot:

NFIB_HUMAN :
  • O00712
Domain:
  • Contains 1 CTF/NF-I DNA-binding domain.
Family:
  • Belongs to the CTF/NF-I family.
genes like me logo Genes that share domains with NFIB: view

No data available for Gene Families for NFIB Gene

Function for NFIB Gene

Molecular function for NFIB Gene

GENATLAS Biochemistry: nuclear transcription factor I B,DNA binding protein
UniProtKB/Swiss-Prot Function: Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication

Gene Ontology (GO) - Molecular Function for NFIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19540848
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IDA 19540848
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 19540848
GO:0001106 RNA polymerase II transcription corepressor activity IDA 9099724
GO:0003677 NOT DNA binding IDA 9099724
genes like me logo Genes that share ontologies with NFIB: view
genes like me logo Genes that share phenotypes with NFIB: view

Animal Models for NFIB Gene

MGI Knock Outs for NFIB:

Animal Model Products

CRISPR Products

Targeting motifs for NFIB Gene
HOMER Transcription Factor Regulatory Elements motif NFIB
  • Consensus sequence: CTTGGCACNGTGCCAA Submotif: canonical Cell Type: LNCAP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFIB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for NFIB Gene

Localization for NFIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFIB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFIB Gene COMPARTMENTS Subcellular localization image for NFIB gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for NFIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0044300 cerebellar mossy fiber ISS --
genes like me logo Genes that share ontologies with NFIB: view

Pathways for NFIB Gene

genes like me logo Genes that share pathways with NFIB: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NFIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9099724
GO:0002062 chondrocyte differentiation ISS --
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with NFIB: view

Transcripts for NFIB Gene

Unigene Clusters for NFIB Gene

Nuclear factor I/B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFIB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFIB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: - -

Relevant External Links for NFIB Gene

GeneLoc Exon Structure for
NFIB
ECgene alternative splicing isoforms for
NFIB

Expression for NFIB Gene

mRNA expression in normal human tissues for NFIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFIB Gene

SOURCE GeneReport for Unigene cluster for NFIB Gene Hs.644095

genes like me logo Genes that share expressions with NFIB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFIB Gene

Orthologs for NFIB Gene

This gene was present in the common ancestor of animals.

Orthologs for NFIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFIB 35
  • 99.39 (n)
  • 99.18 (a)
NFIB 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFIB 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFIB 35
  • 97.07 (n)
  • 98.98 (a)
NFIB 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfib 35
  • 94.27 (n)
  • 98.77 (a)
Nfib 16
Nfib 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFIB 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFIB 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfib 35
  • 94.87 (n)
  • 99.19 (a)
chicken
(Gallus gallus)
Aves NFIB 35
  • 91.6 (n)
  • 97.13 (a)
NFIB 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFIB 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfib 35
  • 84.64 (n)
  • 95.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta NfI 36
  • 27 (a)
OneToMany
CG2380 37
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea nfi-1 36
  • 20 (a)
OneToMany
nfi-1 37
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for NFIB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NFIB Gene

ENSEMBL:
Gene Tree for NFIB (if available)
TreeFam:
Gene Tree for NFIB (if available)

Paralogs for NFIB Gene

Paralogs for NFIB Gene

genes like me logo Genes that share paralogs with NFIB: view

Variants for NFIB Gene

Sequence variations from dbSNP and Humsavar for NFIB Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7858 -- 14,087,770(-) CAGAG(A/G)TGCTG utr-variant-3-prime
rs471088 -- 14,367,506(-) ACAAC(C/T)TTTTG intron-variant
rs475732 -- 14,108,392(-) ATATT(A/G)GTTTA intron-variant
rs483669 -- 14,107,335(-) TTTTT(G/T)TTTGT intron-variant
rs484555 -- 14,085,584(-) TTTTA(C/T)CTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NFIB Gene

Variant ID Type Subtype PubMed ID
nsv892593 CNV Gain 21882294
nsv892595 CNV Gain 21882294
nsv892596 CNV Gain 21882294
nsv892597 CNV Gain 21882294
esv2673979 CNV Deletion 23128226
esv2738220 CNV Deletion 23290073
nsv892598 CNV Gain 21882294
nsv831516 CNV Loss 17160897
esv2669830 CNV Deletion 23128226
nsv528796 CNV Loss 19592680
nsv892599 CNV Loss 21882294
esv991653 OTHER Inversion 20482838
dgv480n21 CNV Loss 19592680
nsv526315 CNV Loss 19592680
nsv892600 CNV Gain 21882294
nsv892601 CNV Gain 21882294
esv2738221 CNV Deletion 23290073
esv2738222 CNV Deletion 23290073
esv2738223 CNV Deletion 23290073
esv2738224 CNV Deletion 23290073
esv6710 CNV Gain 19470904

Relevant External Links for NFIB Gene

HapMap Linkage Disequilibrium report
NFIB
Human Gene Mutation Database (HGMD)
NFIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFIB Gene

Disorders for NFIB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NFIB Gene including...

Search for NFIB Gene in MalaCards »

Relevant External Links for NFIB

Genetic Association Database (GAD)
NFIB
Human Genome Epidemiology (HuGE) Navigator
NFIB
genes like me logo Genes that share disorders with NFIB: view

No data available for UniProtKB/Swiss-Prot for NFIB Gene

Publications for NFIB Gene

  1. NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. (PMID: 9099724) Liu Y. … Apt D. (J. Biol. Chem. 1997) 3 4 23
  2. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PMID: 7590749) Qian F. … Sippel A.E. (Genomics 1995) 2 3 4
  3. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. (PMID: 9484777) Geurts J.M.W. … van de Ven W.J.M. (Oncogene 1998) 3 4
  4. The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. (PMID: 17511965) Mukhopadhyay S.S. … Rosen J.M. (Biochem. Biophys. Res. Commun. 2007) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NFIB Gene

Sources for NFIB Gene

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