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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFIB Gene

protein-coding   GIFtS: 59
GCID: GC09M014077

nuclear factor I/B
 Explore 20 diseases affiliated with
NFIB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NFIB    

Aliases
for NFIB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Factor I/B1 2 3     NF1-B2 3
NFI-RED1 2     NFI-B2 3
NFIB21 2     CCAAT-Box-Binding Transcription Factor2 3
NFIB31 2     TGGCA-Binding Protein2 3
Nuclear Factor 1/B2 3     HMGIC/NFIB2
CTF2 3     Nuclear Factor 1 B-Type2
NF-I/B2 3     

External Ids:    HGNC: 77851   Entrez Gene: 47812   Ensembl: ENSG000001478627   OMIM: 6007285   UniProtKB: O007123   

Export aliases for NFIB gene to outside databases

Previous GC identifers: GC09M014252 GC09M014068


Summaries
for NFIB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NFIB_HUMAN, O00712
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters
and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating
transcription and replication

Gene Wiki entry for NFIB


Genomic Views
for NFIB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFIB gene promoter:
         GR   COMP1   GR-beta   ARP-1   CUTL1   STAT5A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NFIB promoter sequence
   Search SABiosciences Chromatin IP Primers for NFIB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p22.3   HGNC cytogenetic band: 9p24.1

NFIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M014077:  view genomic region     (about GC identifiers)

Start:
 14,081,842 bp from pter      End:
 14,398,982 bp from pter
Size:
 317,141 bases      Orientation:
 minus strand

Proteins
for NFIB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NFIB_HUMAN, O00712 (See protein sequence)
Recommended Name: Nuclear factor 1 B-type  
Size: 420 amino acids; 47442 Da
Subunit: Binds DNA as a homodimer
Subcellular location: Nucleus
Secondary accessions: H7BYE8 O00166 Q12858 Q5VW29 Q6ZNF9 Q96J45
Alternative splicing: 5 isoforms:  O00712-1   O00712-3   O00712-2   O00712-4   O00712-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFIB: NX_O00712

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00712

    • NFIB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177666.1  NP_001177667.1  NP_005587.2  

    ENSEMBL proteins: 
     ENSP00000370346   ENSP00000370340   ENSP00000380705   ENSP00000380711   ENSP00000380709  
     ENSP00000370311   ENSP00000370308   ENSP00000442888   ENSP00000370321  

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    Novus Biologicals NFIB Protein
    Novus Biologicals NFIB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NFIB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0044300cerebellar mossy fiber ISS--


    NFIB for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NFIB

    Protein Domains /
    Families
    for NFIB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NFIB for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019548 CTF/NFI_DNA-bd_N
     IPR000647 CTF/NFI
     IPR019739 CTF/NFI_DNA-bd_CS
     IPR003619 MAD_homology1_Dwarfin-type
     IPR020604 CTF/NFI_DNA-bd-dom

    Graphical View of Domain Structure for InterPro Entry O00712

    ProtoNet protein and cluster: O00712

    1 Blocks protein family: IPB000647 CTF/NF-I family

    UniProtKB/Swiss-Prot: NFIB_HUMAN, O00712
    Similarity: Belongs to the CTF/NF-I family
    Similarity: Contains 1 CTF/NF-I DNA-binding domain


    Function
    for NFIB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NFIB_HUMAN, O00712
    Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters
    and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating
    transcription and replication

         Genatlas biochemistry entry for NFIB:
    nuclear transcription factor I B,DNA binding protein

    miRNA
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    8/314 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIB (see all 314):
    hsa-miR-124* hsa-miR-579 hsa-miR-361-5p hsa-miR-517a hsa-miR-1260b hsa-miR-605 hsa-miR-4275 hsa-miR-1243
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IDA9099724
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ----
    GO:0001106RNA polymerase II transcription corepressor activity IDA9099724
    GO:0003677NOT DNA binding IDA9099724
    GO:0003690double-stranded DNA binding ----


    NFIB for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NFIB:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Nfibtm1Rmg for NFIB
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nfib):
     craniofacial  growth/size  homeostasis/metabolism  mortality/aging  nervous system 
     respiratory system  vision/eye 

    NFIB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NFIB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FOXA1 transcription factor network
    		FOXA1 transcription factor network1.00


    1 BioSystems Pathway for NFIB 
        FOXA1 transcription factor network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for NFIB (O007123 ENSP000003703464) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFICP086513, ENSP000003968434I2D: score=2 STRING: ENSP00000396843
    NFIXQ149383, ENSP000003532194I2D: score=3 STRING: ENSP00000353219
    RFX1P226703, ENSP000002543254I2D: score=2 STRING: ENSP00000254325
    SOX2ENSP000003235884STRING: ENSP00000323588
    SUMO1ENSP000003760764STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9099724
    GO:0002062chondrocyte differentiation ISS--
    GO:0006260DNA replication IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter IDA9099724


    NFIB for ontologies           About GeneDecksing



    Drugs & Compounds
    for NFIB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFIB
    Search CenterWatch for drugs/clinical trials and news about NFIB 

    Transcripts
    for NFIB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NFIB gene (3 alternative transcripts): 
    NM_001190737.1  NM_001190738.1  NM_005596.3  

    Unigene Cluster for NFIB:

    Nuclear factor I/B
    Hs.644095  [show with all ESTs]
    Unigene Representative Sequence: NM_001190737
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380959(uc003zlf.3 uc003zle.3 uc022bdo.1) ENST00000380953
    ENST00000397575 ENST00000397581 ENST00000397579(uc011lmo.2) ENST00000380924
    ENST00000380921 ENST00000493697 ENST00000543693 ENST00000380934(uc003zld.3 uc022bdp.1)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFIB
    8/314 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIB (see all 314):
    hsa-miR-124* hsa-miR-579 hsa-miR-361-5p hsa-miR-517a hsa-miR-1260b hsa-miR-605 hsa-miR-4275 hsa-miR-1243
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFIB (see all 7)
    OriGene shRNA RFP: NFIB
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFIB
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIB 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFIB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFIB

    Additional cDNA sequence: 

    AF022215.1 AK021832.1 AK094066.1 AK129782.1 AK131233.1 AK290603.1 AK299605.1 AL110126.1 
    BC001283.1 BC024316.1 BT007266.1 BX537698.1 BX537707.1 BX648416.1 BX648845.1 U07810.1 
    U70862.1 U85193.1 

    21 DOTS entries:

    DT.450432  DT.100747327  DT.91900755  DT.91662092  DT.91920883  DT.121184205  DT.102843149  DT.445767 
    DT.91768087  DT.95209847  DT.100747326  DT.121184294  DT.40255520  DT.91768084  DT.100677274  DT.95209846 
    DT.100737060  DT.70103842  DT.91768086  DT.95125504  DT.100776919 

    24/432 AceView cDNA sequences (see all 432):

    BE048703 BQ004542 BQ938394 CA445784 AI263997 AI668833 AA722804 AA047635 
    AI971184 AA256680 AI186132 AA780523 F11162 AI091820 BM674718 BM669334 
    BU165126 C00895 AU121970 BX332093 W84385 BU838464 AI129610 AI144540 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NFIB    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                                                        -     -         


    ECgene alternative splicing isoforms for NFIB

    Expression
    for NFIB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACAAACCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NFIB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

    See NFIB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFIB

    SOURCE GeneReport for Unigene cluster: Hs.644095
        SABiosciences Expression via Pathway-Focused PCR Arrays including NFIB: 
              TGFB Signaling Targets in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIB

    Orthologs
    for NFIB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NFIB gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NFIB1 nuclear factor I/B 91.6(n)
    97.13(a)    		   396209  NM_205272.1  NP_990603.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NFIB6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 2(34156851-34354402)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG23803 transcription factor 75(a)   102B3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea nfi-13 Nuclear factor 1 53(a)   II(7534429-7542464)   --


    ENSEMBL Gene Tree for NFIB (if available)
    TreeFam Gene Tree for NFIB (if available) 

    Paralogs
    for NFIB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFIB gene
    NFIC2  NFIA2  NFIX2  
    7 SIMAP similar genes for NFIB using alignment to 8 protein entries:     NFIB_HUMAN (see all proteins):
    DKFZp686E13259    NFIX    NFI    NFIC    DKFZp686I05275    NFIA
    MYB/NFIB fusion

    NFIB for paralogs           About GeneDecksing



    Genomic Variants
    for NFIB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5945 NCBI SNPs in NFIB are shown (see all 5945)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1395261211,2
    		--14081419(+) AGGGTA/GTCCCC 3 -- int10--------
    rs1435479531,2
    		--14081425(+) TCCCCA/GGGGCT 3 -- int10--------
    rs1117402481,2
    		C,--14081508(+) ACATC-/AGTCTT 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs169313241,2
    		F--14081509(+) ACATCG/CTCTTC 3 -- int13Minor allele frequency- C:0.11NA 136
    rs1888239231,2
    		--14081517(+) TTCAAC/TGTATT 3 -- int10--------
    rs607999121,2
    		C--14081576(+) TTTTTTTT/-ACTGT 3 -- int11Minor allele frequency- -:0.50NA 2
    rs1930934791,2
    		--14081610(+) GAAAGA/CTTGGG 3 -- int10--------
    rs1403980861,2
    		C,--14081803(+) CAGAA-/CAGCAAGG 3 -- int10--------
    rs1141507211,2
    		C,--14081839(+) CATGAA/GGCCAG 3 -- int10--------
    rs10596061,2
    		C--14082008(-) TTGCCA/CCAAGT 3 -- ut31 ese33Minor allele frequency- C:0.00MN NA 188

    HapMap Linkage Disequilibrium report for NFIB (14081842 - 14331842 bp, first 250kb of NFIB)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NFIB
         1 CNV: 95852

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    Disorders / Diseases
    for NFIB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NFIB for disorders           About GeneDecksing

    OMIM gene information: 600728    OMIM disorders: --

    20 diseases for NFIB:    About MalaCards
    polymorphous low-grade adenocarcinoma    progressive multifocal leukoencephalopathy    maturity-onset diabetes of the young    adenoid cystic carcinoma
    lipoma    pleomorphic adenoma    myeloproliferative disorder    adenoiditis
    malignant glioma    lipoma of colon    embryonal carcinoma    hepatitis b
    adenoma    pharyngitis    lung cancer    adenocarcinoma
    hepatitis    carcinoma    neuronitis    hiv type 1

    4 diseases from the University of Copenhagen DISEASES database for NFIB:
    Adenoid cystic carcinoma     maturity-onset diabetes of the young     Lipoma of colon     Embryonal carcinoma
    Human Genome Epidemiology (HuGE) Navigator: NFIB (4 documents)

    Export disorders for NFIB gene to outside databases

    Publications
    for NFIB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFIB gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with NFIB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PubMed id 7590749)1, 2, 3 Qian F....Sippel A.E. (1995)
    2. NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. (PubMed id 9099724)1, 2, 9 Liu Y.... Apt D. (1997)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. (PubMed id 9484777)1, 2 Geurts J.M.W.... van de Ven W.J.M. (1998)
    6. The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. (PubMed id 17511965)1, 9 Mukhopadhyay S.S. and Rosen J.M. (2007)
    7. Studies of genomic imbalances and the MYB-NFIB gene f usion in polymorphous low-grade adenocarcinoma of the head and neck. (PubMed id 21901247)1 Persson F....Stenman G. (2012)
    8. Cut-like homeobox 1 and nuclear factor I/B mediate ENG RAILED2 autism spectrum disorder-associated haplotype function. (PubMed id 22180456)1 Choi J....Millonig J.H. (2012)
    9. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    10. Clinically significant copy number alterations and com plex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma. (PubMed id 22505352)1 Persson M....Stenman G. (2012)

    External Searches for NFIB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing NFIB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4781 HGNC: 7785 AceView: NFIB Ensembl:ENSG00000147862 euGenes: HUgn4781
    ECgene: NFIB H-InvDB: NFIB

    Other Databases showing NFIB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NFIB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFIB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFIB Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NFIB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFIB gene:
    Search GeneIP for patents involving NFIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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