Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NFIB Gene

protein-coding   GIFtS: 63
GCID: GC09M014077

Nuclear Factor I/B

  See NFIB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Factor I/B1 2 3     TGGCA-Binding Protein2 3
Nuclear Factor 1/B2 3     HMGIC/NFIB2
CTF2 3     NFI-RED2
NF-I/B2 3     NFIB22
NF1-B2 3     NFIB32
NFI-B2 3     Nuclear Factor 1 B-Type2
CCAAT-Box-Binding Transcription Factor2 3     

External Ids:    HGNC: 77851   Entrez Gene: 47812   Ensembl: ENSG000001478627   OMIM: 6007285   UniProtKB: O007123   

Export aliases for NFIB gene to outside databases

Previous GC identifers: GC09M014252 GC09M014068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NFIB Gene:
NFIB (nuclear factor I/B) is a protein-coding gene. Diseases associated with NFIB include lipoma of colon, and polymorphous low-grade adenocarcinoma. GO annotations related to this gene include RNA polymerase II transcription corepressor activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is NFIC.

UniProtKB/Swiss-Prot: NFIB_HUMAN, O00712
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular
promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of
activating transcription and replication

Gene Wiki entry for NFIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFIB gene promoter:
         GR   COMP1   GR-beta   ARP-1   CUTL1   STAT5A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFIB promoter sequence
   Search Chromatin IP Primers for NFIB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p22.3   HGNC cytogenetic band: 9p24.1

NFIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M014077:  view genomic region     (about GC identifiers)

Start:
14,081,842 bp from pter      End:
14,398,982 bp from pter
Size:
317,141 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NFIB_HUMAN, O00712 (See protein sequence)
Recommended Name: Nuclear factor 1 B-type  
Size: 420 amino acids; 47442 Da
Subunit: Binds DNA as a homodimer
Secondary accessions: H7BYE8 O00166 Q12858 Q5VW29 Q6ZNF9 Q96J45
Alternative splicing: 5 isoforms:  O00712-1   O00712-3   O00712-2   O00712-4   O00712-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NFIB: NX_O00712

Explore proteomics data for NFIB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFIB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001177666.1  NP_001177667.1  NP_001269716.1  NP_005587.2  

    ENSEMBL proteins: 
     ENSP00000370346   ENSP00000370340   ENSP00000380705   ENSP00000380711   ENSP00000380709  
     ENSP00000370311   ENSP00000370308   ENSP00000475362   ENSP00000475813   ENSP00000442888  
     ENSP00000370321  
    Reactome Protein details: O00712

    NFIB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NFIB
    OriGene Protein Over-expression Lysate for NFIB
    OriGene MassSpec for NFIB
    OriGene Custom Protein Services for NFIB
    GenScript Custom Purified and Recombinant Proteins Services for NFIB
    Novus Biologicals NFIB Protein
    Novus Biologicals NFIB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NFIB

     
    Search eBioscience for Proteins for NFIB 

    NFIB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NFIB
    Novus Biologicals NFIB Antibodies
    Abcam antibodies for NFIB
    Cloud-Clone Corp. Antibodies for NFIB
    ThermoFisher Antibodies for NFIB
    LSBio Antibodies in human, mouse, rat for NFIB

    NFIB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFIB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFIB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NFIB
    Cloud-Clone Corp. CLIAs for NFIB
    Search eBioscience for ELISAs for NFIB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR000647 CTF/NFI
     IPR019548 CTF/NFI_DNA-bd_N
     IPR019739 CTF/NFI_DNA-bd_CS
     IPR003619 MAD_homology1_Dwarfin-type
     IPR020604 CTF/NFI_DNA-bd-dom

    Graphical View of Domain Structure for InterPro Entry O00712

    ProtoNet protein and cluster: O00712

    1 Blocks protein domain: IPB000647 CTF/NF-I family

    UniProtKB/Swiss-Prot: NFIB_HUMAN, O00712
    Similarity: Belongs to the CTF/NF-I family
    Similarity: Contains 1 CTF/NF-I DNA-binding domain


    Find genes that share domains with NFIB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFIB_HUMAN, O00712
    Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular
    promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of
    activating transcription and replication

         Genatlas biochemistry entry for NFIB:
    nuclear transcription factor I B,DNA binding protein

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IDA19540848
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001106RNA polymerase II transcription corepressor activity IDA9099724
    GO:0003677NOT DNA binding IDA9099724
    GO:0003690double-stranded DNA binding IEA--
         
    Find genes that share ontologies with NFIB           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NFIB:
     G0/1 arrest  Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nfib):
     craniofacial  growth/size/body  homeostasis/metabolism  mortality/aging  nervous system 
     respiratory system  vision/eye 

    Find genes that share phenotypes with NFIB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nfibtm1Rmg for NFIB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFIB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFIB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFIB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFIB

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CTTGGCACNGTGCCAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NFIB:
    hsa-mir-92a-3p (MIRT049176), hsa-mir-130b-3p (MIRT020191), hsa-mir-192-5p (MIRT026339), hsa-mir-124-3p (MIRT022459), hsa-mir-19b-3p (MIRT031194), hsa-mir-93-5p (MIRT028056), hsa-mir-21-5p (MIRT002090)

    Block miRNA regulation of human, mouse, rat NFIB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFIB (see all 314):
    hsa-miR-124* hsa-miR-579 hsa-miR-361-5p hsa-miR-517a hsa-miR-1260b hsa-miR-605 hsa-miR-4275 hsa-miR-1243
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFIB
    Predesigned siRNA for gene silencing in human, mouse, rat NFIB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFIB

    Clone
    Products:
         
    OriGene clones in human, mouse for NFIB (see all 14)
    OriGene ORF clones in mouse, rat for NFIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NFIB (NM_005596)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFIB
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFIB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NFIB_HUMAN, O00712: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0044300cerebellar mossy fiber ISS--

    Find genes that share ontologies with NFIB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NFIB About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Termination0.58
    RNA Polymerase III Transcription0.88
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    3Gene Expression
    Gene Expression0.40
    4FOXA1 transcription factor network
    FOXA1 transcription factor network


    Find genes that share SuperPaths with NFIB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NFIB
        FOXA1 transcription factor network

    2 Reactome Pathways for NFIB
        RNA Polymerase III Transcription Termination
    RNA Polymerase III Abortive And Retractive Initiation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFIB: 
              TGFB Signaling Targets in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for NFIB (O007123 ENSP000003703464) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFICP086513, ENSP000003968434I2D: score=2 STRING: ENSP00000396843
    NFIXQ149383, ENSP000003532194I2D: score=3 STRING: ENSP00000353219
    RFX1P226703, ENSP000002543254I2D: score=2 STRING: ENSP00000254325
    SOX2ENSP000003235884STRING: ENSP00000323588
    SUMO1ENSP000003760764STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9099724
    GO:0002062chondrocyte differentiation ISS--
    GO:0006260DNA replication IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with NFIB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFIB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NFIB gene (4 alternative transcripts): 
    NM_001190737.1  NM_001190738.1  NM_001282787.1  NM_005596.3  

    Unigene Cluster for NFIB:

    Nuclear factor I/B
    Hs.644095  [show with all ESTs]
    Unigene Representative Sequence: NM_001190737
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380959(uc003zlf.3 uc003zle.3 uc022bdo.1) ENST00000380953
    ENST00000397575 ENST00000397581 ENST00000397579(uc011lmo.2) ENST00000380924
    ENST00000380921 ENST00000493697 ENST00000606230 ENST00000543693 ENST00000380934(uc003zld.3 uc022bdp.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFIB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFIB (see all 314):
    hsa-miR-124* hsa-miR-579 hsa-miR-361-5p hsa-miR-517a hsa-miR-1260b hsa-miR-605 hsa-miR-4275 hsa-miR-1243
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFIB
    Predesigned siRNA for gene silencing in human, mouse, rat NFIB
    Clone
    Products:
         
    OriGene clones in human, mouse for NFIB (see all 14)
    OriGene ORF clones in mouse, rat for NFIB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NFIB (NM_005596)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFIB
    OriGene qSTAR qPCR primer pairs in human, mouse for NFIB
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NFIB
      QuantiTect SYBR Green Assays in human, mouse, rat NFIB
      QuantiFast Probe-based Assays in human, mouse, rat NFIB

    Additional mRNA sequence: 

    AF022215.1 AK021832.1 AK094066.1 AK129782.1 AK131233.1 AK290603.1 AK299605.1 AL110126.1 
    BC001283.1 BC024316.1 BT007266.1 BX537698.1 BX537707.1 BX648416.1 BX648845.1 U07810.1 
    U70862.1 U85193.1 

    21 DOTS entries:

    DT.450432  DT.100747327  DT.91662092  DT.91900755  DT.91920883  DT.102843149  DT.91768087  DT.95209847 
    DT.100747326  DT.121184205  DT.121184294  DT.40255520  DT.91768084  DT.100677274  DT.100737060  DT.70103842 
    DT.91768086  DT.95125504  DT.95209846  DT.100776919  DT.445767 

    Selected AceView cDNA sequences (see all 432):

    AI266227 AA244361 AA047635 BU688029 BQ050777 AI186132 AA232711 BE857223 
    BC001283 AA977525 W84890 BU754293 AI670755 AI830644 AA629608 AI002281 
    BU902064 BU165126 BQ771675 BQ014805 BX332093 BU685112 CA432507 BG742798 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NFIB    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                                                        -     -         


    ECgene alternative splicing isoforms for NFIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NFIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACAAACCT
    NFIB Expression
    About this image


    NFIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
    NFIB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFIB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644095
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFIB: 
              TGFB Signaling Targets in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFIB
    OriGene qSTAR qPCR primer pairs in human, mouse for NFIB
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NFIB
    QuantiTect SYBR Green Assays in human, mouse, rat NFIB
    QuantiFast Probe-based Assays in human, mouse, rat NFIB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NFIB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfib1 , 5 nuclear factor I/B1, 5 94.27(n)1
    98.77(a)1
      4 (38.40 cM)5
    180281  NM_001113209.21  NP_001106680.11 
     822901735 
    chicken
    (Gallus gallus)
    Aves NFIB1 nuclear factor I/B 91.6(n)
    97.13(a)
      396209  NM_205272.1  NP_990603.1 
    lizard
    (Anolis carolinensis)
    Reptilia NFIB6
    nuclear factor I/B
    83(a)
    1 ↔ 1
    2(34156827-34354408)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nfib1 nuclear factor I/B 84.64(n)
    95.06(a)
      100036601  NM_001097167.1  NP_001090636.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG23803 transcription factor 75(a)   102B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea nfi-13 Nuclear factor 1 53(a)   II(7534429-7542464)   --


    ENSEMBL Gene Tree for NFIB (if available)
    TreeFam Gene Tree for NFIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NFIB gene
    NFIC2  NFIA2  NFIX2  
    7 SIMAP similar genes for NFIB using alignment to 10 protein entries:     NFIB_HUMAN (see all proteins):
    DKFZp686E13259    NFIX    NFI    NFIC    DKFZp686I05275    NFIA
    MYB/NFIB fusion

    Find genes that share paralogs with NFIB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NFIB (see all 6841)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395261211,2
    --14081419(+) AGGGTA/GTCCCC 3 -- int10--------
    rs1435479531,2
    --14081425(+) TCCCCA/GGGGCT 3 -- int10--------
    rs1117402481,2
    C--14081508(+) ACATC-/AGTCTT 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs169313241,2
    F--14081509(+) ACATCG/CTCTTC 3 -- int13Minor allele frequency- C:0.11NA 136
    rs1888239231,2
    --14081517(+) TTCAAC/TGTATT 3 -- int10--------
    rs1930934791,2
    --14081610(+) GAAAGA/CTTGGG 3 -- int10--------
    rs1403980861,2
    C--14081803(+) CAGAA-/CAGCAAGG 3 -- int10--------
    rs1141507211,2
    C,F--14081839(+) CATGAA/GGCCAG 3 -- int10--------
    rs10596061,2
    C--14082008(-) TTGCCA/CCAAGT 3 -- ut31 ese33Minor allele frequency- C:0.00MN NA 188
    rs1485628831,2
    C--14082066(+) CCAACA/CGGGCA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for NFIB (14081842 - 14331842 bp, first 250kb of NFIB)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NFIB (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738221CNV Deletion23290073
    esv2673979CNV Deletion23128226
    esv2738223CNV Deletion23290073
    esv2738220CNV Deletion23290073
    esv2669830CNV Deletion23128226
    esv2738224CNV Deletion23290073
    esv2738222CNV Deletion23290073
    nsv526315CNV Loss19592680
    dgv480n21CNV Loss19592680
    nsv528796CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFIB
    DNA2.0 Custom Variant and Variant Library Synthesis for NFIB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600728    OMIM disorders: --

    2 diseases for NFIB:    
    About MalaCards
    lipoma of colon    polymorphous low-grade adenocarcinoma

    4 diseases from the University of Copenhagen DISEASES database for NFIB:
    Adenoid cystic carcinoma     maturity-onset diabetes of the young     Lipoma of colon     Embryonal carcinoma

    Find genes that share disorders with NFIB           About GenesLikeMe

    Genetic Association Database (GAD): NFIB
    Human Genome Epidemiology (HuGE) Navigator: NFIB (4 documents)

    Export disorders for NFIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NFIB gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with NFIB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PubMed id 7590749)1, 2, 3 Qian F.... Sippel A.E. (Genomics 1995)
    2. NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. (PubMed id 9099724)1, 2, 9 Liu Y.... Apt D. (J. Biol. Chem. 1997)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. (PubMed id 9484777)1, 2 Geurts J.M.W.... van de Ven W.J.M. (Oncogene 1998)
    7. The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells. (PubMed id 17511965)1, 9 Mukhopadhyay S.S. and Rosen J.M. (Biochem. Biophys. Res. Commun. 2007)
    8. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. (PubMed id 23419831)1 Ramanan V.K....Saykin A.J. (Mol. Psychiatry 2013)
    9. MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. (PubMed id 23161775)1 Ho C.Y....Rodriguez F.J. (Neuro-oncology 2013)
    10. Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck. (PubMed id 21901247)1 Persson F....Stenman G. (Int. J. Oncol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4781 HGNC: 7785 AceView: NFIB Ensembl:ENSG00000147862 euGenes: HUgn4781
    ECgene: NFIB H-InvDB: NFIB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NFIB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NFIB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NFIB gene:
    Search GeneIP for patents involving NFIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NFIB  
     OriGene qPCR primer pairs and template standards for NFIB   OriGene Protein Over-expression Lysate for NFIB  
     OriGene MassSpec something-or-other for NFIB   OriGene clones in human, mouse for NFIB  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFIB   OriGene Purified Protein for NFIB  
     OriGene ORF clones in mouse, rat for NFIB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFIB   OriGene Custom Protein Services for NFIB  

     
     
     Block miRNA regulation of human, mouse, rat NFIB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NFIB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFIB Predesigned siRNA for gene silencing in human, mouse, rat NFIB
     QuantiFast Probe-based Assays in human, mouse, rat NFIB QuantiTect SYBR Green Assays in human, mouse, rat NFIB
     PCR Arrays including human, mouse / rat NFIB Search Chromatin IP Primers for NFIB
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NFIB  GeneGlobe Interaction Network for NFIB
     Regulatory tfbs in NFIB promoter
     GenScript Custom Purified and Recombinant Proteins Services for NFIB GenScript cDNA clones with any tag delivered in your preferred vector for NFIB
     GenScript Custom Assay Services for NFIB GenScript Custom overexpressing Cell Line Services for NFIB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NFIB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NFIB antibodies
     NFIB proteins
     NFIB lysates
     Antibodies for NFIB
     See all of Abcam's Antibodies, Kits and Proteins for NFIB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NFIB
     Antibodies for NFIB
     ELISAs for NFIB
     CLIAs for NFIB



     Browse ESI BIO Cell Lines and PureStem Progenitors for NFIB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIB
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NFIB
     SwitchGear Promoter luciferase reporter plasmids for NFIB
     ThermoFisher Antibodies for NFIB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFIB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFIB
     LSBio Antibodies in human, mouse, rat for NFIB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NFIB
      Search eBioscience for proteins for NFIB
      Search eBioscience for elisas for NFIB
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFIB gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4