Aliases for NFIA Gene
External Ids for NFIA Gene
Previous GeneCards Identifiers for NFIA Gene
This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for NFIA Gene
NFIA (Nuclear Factor I A) is a Protein Coding gene. Diseases associated with NFIA include Chromosome 1P32-P31 Deletion Syndrome and Leukemia, Acute Promyelocytic, Somatic. Among its related pathways are RNA Polymerase III Transcription Initiation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NFIC.
UniProtKB/Swiss-Prot for NFIA Gene
Recognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.