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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFIA Gene

protein-coding   GIFtS: 59
GCID: GC01P061260

nuclear factor I/A
 Explore 14 diseases affiliated with
NFIA via
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 Human Malady Compendium 
Biological research products
for NFIA    

Aliases
for NFIA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Factor I/A1 2 3     NFI-A2 3
NFI-L1 2     CCAAT-Box-Binding Transcription Factor2 3
KIAA14391 3     TGGCA-Binding Protein2 3
CTF2 3     Nuclear Factor 1 A-Type2
NF-I/A2 3     Nuclear Factor 1/A3
NF1-A2 3     

External Ids:    HGNC: 77841   Entrez Gene: 47742   Ensembl: ENSG000001625997   OMIM: 6007275   UniProtKB: Q128573   

Export aliases for NFIA gene to outside databases

Previous GC identifers: GC01P061481 GC01P060471 GC01P060905 GC01P060917 GC01P060918 GC01P061103 GC01P059635


Summaries
for NFIA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NFIA:
This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: NFIA_HUMAN, Q12857
Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters
and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating
transcription and replication

Gene Wiki entry for NFIA


Genomic Views
for NFIA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFIA gene promoter:
         E2F-5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NFIA promoter sequence
   Search SABiosciences Chromatin IP Primers for NFIA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFIA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3-p31.2   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3-p31.2

NFIA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFIA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P061260:  view genomic region     (about GC identifiers)

Start:
 61,330,931 bp from pter      End:
 61,928,465 bp from pter
Size:
 597,535 bases      Orientation:
 plus strand

Proteins
for NFIA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NFIA_HUMAN, Q12857 (See protein sequence)
Recommended Name: Nuclear factor 1 A-type  
Size: 509 amino acids; 55944 Da
Subunit: Binds DNA as a homodimer
Subcellular location: Nucleus
Sequence caution: Sequence=BAA92677.1; Type=Erroneous initiation;
Secondary accessions: Q8TA97 Q9H3X9 Q9P2A9
Alternative splicing: 2 isoforms:  Q12857-1   Q12857-2   

Explore the universe of human proteins at neXtProt for NFIA: NX_Q12857

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12857

    • NFIA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128145.1  NP_001138983.1  NP_001138984.1  NP_005586.1  

    ENSEMBL proteins: 
     ENSP00000360233   ENSP00000384523   ENSP00000419785   ENSP00000360227   ENSP00000360226  
     ENSP00000360229   ENSP00000384680   ENSP00000360231  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: NFIA
    OriGene Protein Over-expression Lysate (see all 2): NFIA
    OriGene Custom Protein Services for NFIA 
    GenScript Custom Purified and Recombinant Proteins Services for NFIA
    Novus Biologicals NFIA Protein
    Novus Biologicals NFIA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NFIA

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7590749
    GO:0005730NOT nucleolus IDA--
    GO:0030054cell junction IDA--


    NFIA for ontologies           About GeneDecksing



    NFIA Antibody Products: 
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    Search for Antibodies for NFIA at Abcam  
    Uscn Antibodies for NFIA
    Search ThermoFisher Antibodies for NFIA

    Assay Products for NFIA: 
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    Uscn ELISAs and CLIAs for NFIA

    Protein Domains /
    Families
    for NFIA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NFIA for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019548 CTF/NFI_DNA-bd_N
     IPR000647 CTF/NFI
     IPR019739 CTF/NFI_DNA-bd_CS
     IPR003619 MAD_homology1_Dwarfin-type
     IPR020604 CTF/NFI_DNA-bd-dom

    Graphical View of Domain Structure for InterPro Entry Q12857

    ProtoNet protein and cluster: Q12857

    1 Blocks protein family: IPB000647 CTF/NF-I family

    UniProtKB/Swiss-Prot: NFIA_HUMAN, Q12857
    Similarity: Belongs to the CTF/NF-I family
    Similarity: Contains 1 CTF/NF-I DNA-binding domain


    Function
    for NFIA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NFIA_HUMAN, Q12857
    Function: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters
    and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating
    transcription and replication

         Genatlas biochemistry entry for NFIA:
    nuclear transcription factor I A,DNA binding protein

    miRNA
    Products:            		miRTarBase miRNAs that target NFIA:
    hsa-mir-424 (MIRT003928), hsa-mir-107 (MIRT004811), hsa-mir-223 (MIRT004522)

    OriGene 3'-UTR Clone (see all 4): NFIA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFIA
    8/285 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIA (see all 285):
    hsa-miR-361-5p hsa-miR-520f hsa-miR-517a hsa-miR-605 hsa-miR-4275 hsa-miR-642b hsa-miR-200b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmid: NFIA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFIA (see all 6)
    OriGene siRNA: NFIA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFIA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NFIA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFIA (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFIA (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): NFIA (NM_005595)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NFIA
    Search LifeMap BioReagents cell lines for NFIA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIA

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7590749
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IPI15684392


    NFIA for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nfiatm1Rmg for NFIA
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nfia):
     behavior/neurological  cellular  craniofacial  growth/size  mortality/aging 
     nervous system  other  renal/urinary system  reproductive system 

    NFIA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NFIA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1FOXA1 transcription factor network
    		FOXA1 transcription factor network1.00


    1 BioSystems Pathway for NFIA 
        FOXA1 transcription factor network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFIA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for NFIA (Q128572, 3 ENSP000003845234) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    C4BPBENSP000002436114STRING: ENSP00000243611
    POLR3AENSP000003614464STRING: ENSP00000361446
    POLR3DENSP000003030884STRING: ENSP00000303088
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS7590749
    GO:0014070response to organic cyclic compound ----
    GO:0019079viral genome replication NAS7590749


    NFIA for ontologies           About GeneDecksing



    Drugs & Compounds
    for NFIA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NFIA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFIA
    1 Novoseek chemical compound relationship for NFIA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 27.2 3 16325577 (2)

    Search CenterWatch for drugs/clinical trials and news about NFIA 

    Transcripts
    for NFIA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NFIA gene (4 alternative transcripts): 
    NM_001134673.3  NM_001145511.1  NM_001145512.1  NM_005595.4  

    Unigene Cluster for NFIA:

    Nuclear factor I/A
    Hs.191911  [show with all ESTs]
    Unigene Representative Sequence: NM_001134673
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371191 ENST00000476646 ENST00000479364 ENST00000403491(uc001czw.3 uc001czv.3 uc001czx.3 uc009wae.3)
    ENST00000485903 ENST00000371185 ENST00000371184 ENST00000371187 ENST00000496712
    ENST00000482020 ENST00000357977 ENST00000493627 ENST00000407417(uc001czy.3)
    ENST00000371189(uc010oos.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): NFIA
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFIA
    8/285 QIAGEN miScript miRNA Assays for microRNAs that regulate NFIA (see all 285):
    hsa-miR-361-5p hsa-miR-520f hsa-miR-517a hsa-miR-605 hsa-miR-4275 hsa-miR-642b hsa-miR-200b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmid: NFIA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFIA (see all 6)
    OriGene siRNA: NFIA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFIA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFIA (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFIA (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): NFIA (NM_005595)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFIA 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFIA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFIA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFIA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFIA

    Additional cDNA sequence: 

    AB037860.1 AF086381.1 AK024964.1 AK092769.1 AK096483.1 AK299289.1 AK299356.1 AK299579.1 
    AL133665.1 BC022264.1 BX537823.1 BX648791.1 U07809.1 

    24/25 DOTS entries (see all 25):

    DT.311197  DT.214428  DT.95295025  DT.91798926  DT.95328544  DT.91877211  DT.95125589  DT.100020657 
    DT.121418167  DT.97812492  DT.99968162  DT.75131028  DT.114671  DT.95334777  DT.121433839  DT.121418273 
    DT.91751280  DT.99976543  DT.100748421  DT.121418214  DT.92419133  DT.95365571  DT.100019546  DT.100812633 

    24/203 AceView cDNA sequences (see all 203):

    AI246670 AI379277 N66983 AL119720 AI810899 F01545 F01550 AB037860 
    AA600353 AI474446 BM464424 AI824498 AI287535 AA598615 F05295 F08494 
    AI143309 AA548405 Z42533 BQ881315 AA776223 Z38724 AW264052 AI368516 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NFIA    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                -                                   -                           
    SP2:                                -                                   -                 -         
    SP3:                                                                                                
    SP4:        -                                                                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for NFIA

    Expression
    for NFIA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFIA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NFIA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    BoneMaxillary ProcessBone
    BoneZeugopod Epiphyseal EndBone
    Gut TubeVentral Foregut EndodermGut Tube
    Intermediate MesodermIntermediate MesodermIntermediate Mesoderm
    KidneyMetanephrosKidney
    KidneyS-shaped BodyKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

    See NFIA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFIA

    SOURCE GeneReport for Unigene cluster: Hs.191911
        SABiosciences Custom PCR Arrays for NFIA
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFIA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFIA

    Orthologs
    for NFIA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NFIA gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NFIA1 nuclear factor I/A 91.55(n)
    98.82(a)    		   396210  NM_205273.1  NP_990604.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 92(a)
    100(a)
    		 1 ↔ many
    1 ↔ many
    		 4(100413892-100586322)
    4(100793095-100799778)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.152682 Transcribed sequence with moderate similarity to protein more 82.78(n)    BI429392.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG23803
    NfI1    		 transcription factor3
    Nuclear factor I1    		 44(a)3
    53.49(n)1
    48.6(a)1    		   102B33
    437821  NM_205870.21  NP_995592.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea nfi-16
    		 NFI (Nuclear Factor I) family member (nfi-1)
    		 19(a)
    		 1 → many
    		 II(7538146-7542957)


    ENSEMBL Gene Tree for NFIA (if available)
    TreeFam Gene Tree for NFIA (if available) 

    Paralogs
    for NFIA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFIA gene
    NFIC2  NFIB2  NFIX2  
    6 SIMAP similar genes for NFIA using alignment to 7 protein entries:     NFIA_HUMAN (see all proteins):
    NFIX    NFI    NFIB    DKFZp686I05275    NFIC    DKFZp686E13259

    NFIA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NFIA
    PGOHUM00000235969


    Genomic Variants
    for NFIA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6648 NCBI SNPs in NFIA are shown (see all 6648)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1128194741,2
    		--59649963(+) CAGGCG/TGGAGT 1 -- int13Minor allele frequency- T:0.06CSA WA EA 240
    rs1117981671,2
    		C,--59650004(+) CCGCCT/ACCCAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs799013611,2
    		F,--59650476(+) CTGTGT/CGTCAA 1 -- int11Minor allele frequency- C:0.05WA 118
    rs800324431,2
    		--59651042(+) TCAGCA/GGAGGG 1 -- int10--------
    rs568070221,2
    		F,--59651543(+) CCACAT/GAGCCT 1 -- int11Minor allele frequency- G:0.06WA 118
    rs2011125511,2
    		C--59651927(+) TGTGTA/GTATAT 1 -- int10--------
    rs769949131,2
    		F,--59652016(+) CCATTG/ACACTG 1 -- int11Minor allele frequency- A:0.05WA 118
    rs754897651,2
    		F,--59652146(+) TCTCCC/TATTTT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs726648101,2
    		C,--59652156(+) TCCAGA/CTCAGA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1121736401,2
    		--59652779(+) TCTGCG/ATCTCA 1 -- int12Minor allele frequency- A:0.33CSA 3

    HapMap Linkage Disequilibrium report for NFIA (61330931 - 61580931 bp, first 250kb of NFIA)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NFIA
         1 CNV: 63871
    Human Gene Mutation Database (HGMD): NFIA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFIA
    DNA2.0 Custom Variant and Variant Library Synthesis for NFIA

    Disorders / Diseases
    for NFIA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NFIA for disorders           About GeneDecksing

    OMIM gene information: 600727    OMIM disorders: --

    14 diseases for NFIA:    About MalaCards
    progressive multifocal leukoencephalopathy    maturity-onset diabetes of the young    corpus callosum    acute promyelocytic leukemia
    malignant glioma    bipolar disorder    celiac disease    hydrocephalus
    embryonal carcinoma    choroiditis    pharyngitis    leukemia
    neuronitis    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for NFIA:
    maturity-onset diabetes of the young     Embryonal carcinoma

    1 Novoseek disease relationship for NFIA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 50.8 1 16325577 (1)

    Human Genome Epidemiology (HuGE) Navigator: NFIA (4 documents)

    Export disorders for NFIA gene to outside databases

    Publications
    for NFIA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFIA gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with NFIA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. (PubMed id 7590749)1, 2, 3, 9 Qian F....Sippel A.E. (1995)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    5. NFI-A directs the fate of hematopoietic progenitors t o the erythroid or granulocytic lineage and controls beta-globin and G-CSF rece ptor expression. (PubMed id 19542302)1, 9 Starnes L.M....Peschle C. (2009)
    6. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. (PubMed id 16325577)1, 9 Fazi F....Bozzoni I. (2005)
    7. Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A. (PubMed id 17010934)1, 9 Lin Y.L....Lee H.J. (2006)
    8. Nuclear factor I regulates brain fatty acid-binding p rotein and glial fibrillary acidic protein gene expression in malignant glioma cell lines. (PubMed id 19540848)1, 9 Brun M....Godbout R. (2009)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Evidence that nuclear factor IA inhibits repair after white matter injury. (PubMed id 22807310)1 Fancy S.P....Deneen B. (2012)

    External Searches for NFIA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NFIA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4774 HGNC: 7784 AceView: NFIA Ensembl:ENSG00000162599 euGenes: HUgn4774
    ECgene: NFIA H-InvDB: NFIA

    Other Databases showing NFIA gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1439

    Specialized Databases showing NFIA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFIA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NFIA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFIA gene:
    Search GeneIP for patents involving NFIA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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