Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NFE2L3 Gene

protein-coding   GIFtS: 52
GCID: GC07P026158

nuclear factor (erythroid-derived 2)-like 3
 Explore 6 diseases affiliated with
NFE2L3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NFE2L3    

Aliases
for NFE2L3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Factor (Erythroid-Derived 2)-Like 31 2     Nrf31
NRF32 3 5     Nuclear Factor Erythroid 2-Related Factor 32
Nuclear Factor, Erythroid Derived 2, Like 32 3     Nuclear Factor-Erythroid 2 P45-Related Factor 32
NF-E2-Related Factor 32 3     Nuclear Factor-Erythroid 2-Related Factor 32
NFE2-Related Factor 32 3     

External Ids:    HGNC: 77831   Entrez Gene: 96032   Ensembl: ENSG000000503447   OMIM: 6041355   UniProtKB: Q9Y4A83   

Export aliases for NFE2L3 gene to outside databases

Previous GC identifers: GC07P025834 GC07P025934 GC07P025965


Summaries
for NFE2L3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NFE2L3:
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The
encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response
elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum
and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. (provided by RefSeq, Mar
2009)

UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8
Function: Activates erythroid-specific, globin gene expression

Gene Wiki entry for NFE2L3


Genomic Views
for NFE2L3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NFE2L3 gene promoter:
         Pax-5   NCX/Ncx   MyoD   POU3F2   Arnt   Egr-2   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NFE2L3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFE2L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

NFE2L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFE2L3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P026158:  view genomic region     (about GC identifiers)

Start:
 26,191,847 bp from pter      End:
 26,226,757 bp from pter
Size:
 34,911 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 26,242,879-26,277,907     

Proteins
for NFE2L3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8 (See protein sequence)
Recommended Name: Nuclear factor erythroid 2-related factor 3  
Size: 694 amino acids; 76154 Da
Subunit: Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAP22344.1; Type=Erroneous gene model prediction; Sequence=BAA76288.1; Type=Erroneous
initiation;
Secondary accessions: Q6NUS0 Q7Z498 Q86UJ4 Q86VR5 Q9UQA4

Explore the universe of human proteins at neXtProt for NFE2L3: NX_Q9Y4A8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y4A8

    • NFE2L3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004280.5  
    ENSEMBL proteins: 
     ENSP00000056233  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NFE2L3 
    GenScript Custom Purified and Recombinant Proteins Services for NFE2L3
    Novus Biologicals NFE2L3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NFE2L3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    NFE2L3 for ontologies           About GeneDecksing



    NFE2L3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NFE2L3 
    GenScript Custom Superior Antibodies Services for NFE2L3
    Search for Antibodies for NFE2L3 at Abcam  
    Uscn Antibodies for NFE2L3
    Search ThermoFisher Antibodies for NFE2L3

    Assay Products for NFE2L3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFE2L3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NFE2L3

    Protein Domains /
    Families
    for NFE2L3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NFE2L3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004827 bZIP
     IPR008917 Euk_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y4A8

    ProtoNet protein and cluster: Q9Y4A8

    1 Blocks protein family: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8
    Similarity: Belongs to the bZIP family. CNC subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Function
    for NFE2L3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8
    Function: Activates erythroid-specific, globin gene expression

         Genatlas biochemistry entry for NFE2L3:
    nuclear factor (erythroid-derived 2)-like 3,Cap'n'collar (CNC) family of transcription factor,highly expressed in
    placenta,B cell and monocyte lineage

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NFE2L3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFE2L3
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate NFE2L3:
    hsa-miR-26a hsa-miR-33b hsa-miR-4282 hsa-miR-26b hsa-miR-33a hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmid: NFE2L3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFE2L3 (see all 4)
    OriGene shRNA RFP: NFE2L3
    OriGene siRNA: NFE2L3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFE2L3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NFE2L3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NFE2L3 (NM_004289)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFE2L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NFE2L3
    Search LifeMap BioReagents cell lines for NFE2L3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS10037736
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046983protein dimerization activity ----


    NFE2L3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nfe2l3tm1Vbl for NFE2L3
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nfe2l3):
     mortality/aging  normal 

    NFE2L3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NFE2L3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFE2L3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for NFE2L3 (Q9Y4A83 ENSP000000562334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAFKO606753, ENSP000003449034I2D: score=3 STRING: ENSP00000344903
    MAFGO155253I2D: score=1 
    NFE2Q166213I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS10037736


    NFE2L3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NFE2L3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NFE2L3
    Search CenterWatch for drugs/clinical trials and news about NFE2L3 / NF2L3 

    Transcripts
    for NFE2L3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NFE2L3 gene: 
    NM_004289.6  

    Unigene Clusters for NFE2L3:

    Nuclear factor (erythroid-derived 2)-like 3
    Hs.404741  [show with all ESTs], Hs.712898  [show with all ESTs]
    Unigene Representative Sequences: NM_004289, BE540023
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000056233(uc003sxq.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NFE2L3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFE2L3
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate NFE2L3:
    hsa-miR-26a hsa-miR-33b hsa-miR-4282 hsa-miR-26b hsa-miR-33a hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmid: NFE2L3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFE2L3 (see all 4)
    OriGene shRNA RFP: NFE2L3
    OriGene siRNA: NFE2L3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFE2L3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NFE2L3 (NM_004289)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFE2L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFE2L3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFE2L3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFE2L3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFE2L3

    Additional cDNA sequence: BC008645.1 

    5 DOTS entries:

    DT.453116  DT.100790432  DT.100840048  DT.100653634  DT.101958724 

    24/132 AceView cDNA sequences (see all 132):

    AF133059 CB160489 AA962733 AA603252 AI701886 BX396198 AW662710 AA305111 
    BG178514 BM142211 BU690027 CR595336 BF589057 BE042803 AA501998 CB160493 
    BM784805 AI621283 AI919099 CA776025 AA331415 AA132523 BC056142 CB161133 

    GeneLoc Exon Structure


    Expression
    for NFE2L3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NFE2L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACCCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NFE2L3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Posterior foregut-like cells (A scalable, suspensi...)

    See NFE2L3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NFE2L3

    SOURCE GeneReport for Unigene clusters: Hs.404741 Hs.712898

    UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8
    Tissue specificity: Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in
    heart, brain, lung, skeletal muscle, kidney and pancreas

        SABiosciences Custom PCR Arrays for NFE2L3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFE2L3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFE2L3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFE2L3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFE2L3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L3

    Orthologs
    for NFE2L3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NFE2L3 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NFE2L36
    		 --
    		 42(a)
    		 1 ↔ 1
    		 6(31847527-31848558)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.171622 Transcribed sequence with weak similarity to protein more 71.6(n)    142021309 
    zebrafish
    (Danio rerio)    		 Actinopterygii nfe2l36
    si:dkey-3d18.46
    		 si:dkey-3d18.4
    		 24(a)
    20(a)
    		 1 ↔ 1
    possible ortholog
    		 19(20278282-20287096)
    6(10799745-10813863)
    fruit fly
    (Drosophila melanogaster)    		 Insecta cnc3 blastoderm segmentation transcription factor 48(a)     --


    ENSEMBL Gene Tree for NFE2L3 (if available)
    TreeFam Gene Tree for NFE2L3 (if available) 

    Paralogs
    for NFE2L3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NFE2L3 gene
    NFE2L12  BACH22  BACH12  NFE22  NFE2L22  
    3 SIMAP similar genes for NFE2L3 using alignment to 2 protein entries:     NF2L3_HUMAN (see all proteins):
    NFE2    NFE2L1    FLJ00380

    NFE2L3 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for NFE2L3
    PGOHUM00000248159 PGOHUM00000249118 PGOHUM00000237425 PGOHUM00000235077


    Genomic Variants
    for NFE2L3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/649 NCBI SNPs in NFE2L3 are shown (see all 649)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1869832101,2
    		--26189866(+) TGCTTA/TTGAAG 1 -- us2k10--------
    rs1894848811,2
    		--26189900(+) CACTAC/TGATTA 1 -- us2k10--------
    rs1409826481,2
    		--26190034(+) CAATTC/TAACTA 1 -- us2k10--------
    rs47225871,2
    		C,F,H,--26190086(+) GCACCA/GCCTTG 1 -- us2k122Minor allele frequency- G:0.03NS EA NA WA CSA 1593
    rs132286461,2
    		C,F,H,--26190193(+) TTCTCT/CTGTTT 1 -- us2k1 tfbs323Minor allele frequency- C:0.30NS EA NA WA 2754
    rs1807314851,2
    		--26190267(+) AACTCC/TGTTTC 1 -- us2k10--------
    rs559700001,2
    		C,--26190344(+) CATTTA/CCTAAG 1 -- us2k10--------
    rs1464932661,2
    		--26190446(+) CCAACC/TCATCT 1 -- us2k10--------
    rs37576731,2
    		C,F,H,--26190616(-) GGGCAG/CTTGTG 1 -- us2k16Minor allele frequency- C:0.07EA NS 2028
    rs744606701,2
    		C,--26190652(+) TCCCCT/CTTTCT 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for NFE2L3 (26191847 - 26226757 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for NFE2L3
         3 CNVs: 81891 94424 64786
         1 Indel: 28613

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFE2L3
    DNA2.0 Custom Variant and Variant Library Synthesis for NFE2L3

    Disorders / Diseases
    for NFE2L3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NFE2L3 for disorders           About GeneDecksing

    OMIM gene information: 604135    OMIM disorders: --

    6 diseases for NFE2L3:    About MalaCards
    fibrosarcoma    gestational choriocarcinoma    placental cancer    hepatitis b
    choriocarcinoma    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: NFE2L3 (7 documents)

    Export disorders for NFE2L3 gene to outside databases

    Publications
    for NFE2L3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NFE2L3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NFE2L3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (PubMed id 10037736)1, 2, 3, 9 Kobayashi A.... Yamamoto M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Functional and placental expression analysis of the human NRF3 transcription factor. (PubMed id 15388789)1, 9 Chenais B....Blank V. (2005)
    5. Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor. (PubMed id 17976382)1, 9 Nouhi Z....Blank V. (2007)
    6. Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin. (PubMed id 11286316)1, 9 Terui K....Ito E. (2000)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distr ibution. (PubMed id 20935629)1 Heid I.M....Lindgren C.M. (2010)

    External Searches for NFE2L3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NFE2L3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9603 HGNC: 7783 AceView: NFE2L3 Ensembl:ENSG00000050344 euGenes: HUgn9603
    ECgene: NFE2L3 H-InvDB: NFE2L3

    Other Databases showing NFE2L3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NFE2L3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NFE2L3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NFE2L3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NFE2L3 gene:
    Search GeneIP for patents involving NFE2L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NFE2L3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NFE2L3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFE2L3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFE2L3  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NFE2L3   OriGene 3'-UTR Clone for NFE2L3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFE2L3   OriGene Custom Protein Services for NFE2L3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFE2L3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFE2L3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFE2L3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFE2L3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFE2L3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFE2L3
     GenScript Custom Purified and Recombinant Proteins Services for NFE2L3 GenScript cDNA clones with any tag delivered in your preferred vector for NFE2L3
     GenScript Custom Assay Services for NFE2L3 GenScript Custom Superior Antibodies Services for NFE2L3
     GenScript Custom overexpressing Cell Line Services for NFE2L3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NFE2L3 promoter
     Search Chromatin IP Primers for NFE2L3
     RT2 qPCR Primer Assay in human, mouse, rat NFE2L3
     GNC Network for NFE2L3
     SABiosciences Custom PCR Arrays for NFE2L3
     Search Tocris compounds for NFE2L3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NFE2L3 proteins
     Search for Antibodies for NFE2L3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NFE2L3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NFE2L3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NFE2L3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L3
     SwitchGear 3'UTR luciferase reporter plasmids for NFE2L3
     Browse SwitchGear Promoter luciferase reporter plasmids for NFE2L3
     Search ThermoFisher Antibodies for NFE2L3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NFE2L3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4