Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NFE2L3 Gene

protein-coding   GIFtS: 52
GCID: GC07P026191

Nuclear Factor, Erythroid 2-Like 3

(Previous name: nuclear factor (erythroid-derived 2)-like 3)
  See NFE2L3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Factor, Erythroid 2-Like 31 2     NFE2-Related Factor 32 3
NRF32 3 5     Nuclear Factor Erythroid 2-Related Factor 32
Nuclear Factor (Erythroid-Derived 2)-Like 31 2     Nuclear Factor-Erythroid 2 P45-Related Factor 32
Nuclear Factor, Erythroid Derived 2, Like 32 3     Nuclear Factor-Erythroid 2-Related Factor 32
NF-E2-Related Factor 32 3     

External Ids:    HGNC: 77831   Entrez Gene: 96032   Ensembl: ENSG000000503447   OMIM: 6041355   UniProtKB: Q9Y4A83   

Export aliases for NFE2L3 gene to outside databases

Previous GC identifers: GC07P025834 GC07P025934 GC07P025965 GC07P026158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NFE2L3 Gene:
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The
encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response
elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic
reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. (provided
by RefSeq, Mar 2009)

GeneCards Summary for NFE2L3 Gene:
NFE2L3 (nuclear factor, erythroid 2-like 3) is a protein-coding gene. Diseases associated with NFE2L3 include fibrosarcoma. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BACH2.

UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8
Function: Activates erythroid-specific, globin gene expression

Gene Wiki entry for NFE2L3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFE2L3 gene promoter:
         Pax-5   NCX/Ncx   MyoD   POU3F2   Arnt   Egr-2   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NFE2L3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFE2L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

NFE2L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFE2L3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P026191:  view genomic region     (about GC identifiers)

Start:
26,191,847 bp from pter      End:
26,226,757 bp from pter
Size:
34,911 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 26,242,879-26,277,907     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8 (See protein sequence)
Recommended Name: Nuclear factor erythroid 2-related factor 3  
Size: 694 amino acids; 76154 Da
Subunit: Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements
(MARE)
Sequence caution: Sequence=AAP22344.1; Type=Erroneous gene model prediction; Sequence=BAA76288.1; Type=Erroneous
initiation;
Secondary accessions: Q6NUS0 Q7Z498 Q86UJ4 Q86VR5 Q9UQA4

Explore the universe of human proteins at neXtProt for NFE2L3: NX_Q9Y4A8

Explore proteomics data for NFE2L3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFE2L3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004280.5  
    ENSEMBL proteins: 
     ENSP00000056233   ENSP00000475463  

    NFE2L3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NFE2L3
    GenScript Custom Purified and Recombinant Proteins Services for NFE2L3
    Novus Biologicals NFE2L3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NFE2L3

     
    Search eBioscience for Proteins for NFE2L3 

     
    antibodies-online proteins for NFE2L3 (6 products) 

     
    antibodies-online peptides for NFE2L3

    NFE2L3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NFE2L3
    OriGene Custom Antibody Services for NFE2L3
    Novus Biologicals NFE2L3 Antibody
    Abcam antibodies for NFE2L3
    Cloud-Clone Corp. Antibodies for NFE2L3
    Search ThermoFisher Antibodies for NFE2L3
    antibodies-online antibodies for NFE2L3 (21 products) 

    NFE2L3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NFE2L3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NFE2L3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NFE2L3
    Cloud-Clone Corp. CLIAs for NFE2L3
    Search eBioscience for ELISAs for NFE2L3 
    antibodies-online kits for NFE2L3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR008917 TF_DNA-bd
     IPR004826 bZIP_Maf

    Graphical View of Domain Structure for InterPro Entry Q9Y4A8

    ProtoNet protein and cluster: Q9Y4A8

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8
    Similarity: Belongs to the bZIP family. CNC subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with NFE2L3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NF2L3_HUMAN, Q9Y4A8
    Function: Activates erythroid-specific, globin gene expression

         Genatlas biochemistry entry for NFE2L3:
    nuclear factor (erythroid-derived 2)-like 3,Cap'n'collar (CNC) family of transcription factor,highly expressed in
    placenta,B cell and monocyte lineage

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS10037736
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with NFE2L3           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nfe2l3):
     mortality/aging  normal 

    Find genes that share phenotypes with NFE2L3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nfe2l3tm1Vbl for NFE2L3

       genOway: Develop your customized and physiologically relevant rodent model for NFE2L3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NFE2L3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NFE2L3:
    hsa-miR-26a hsa-miR-33b hsa-miR-4282 hsa-miR-26b hsa-miR-33a hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidNFE2L3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFE2L3
    Predesigned siRNA for gene silencing in human, mouse, rat NFE2L3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFE2L3

    Clone
    Products:
         
    OriGene clones in human, mouse for NFE2L3 (see all 7)
    OriGene ORF clones in mouse, rat for NFE2L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFE2L3 (NM_004289)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFE2L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NFE2L3
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFE2L3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NF2L3_HUMAN, Q9Y4A8: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with NFE2L3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NFE2L3
    Interactions:

        GeneGlobe Interaction Network for NFE2L3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for NFE2L3 (Q9Y4A83 ENSP000000562334) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAFKO606753, ENSP000003449034I2D: score=3 STRING: ENSP00000344903
    MAFGO155253I2D: score=1 
    NFE2Q166213I2D: score=1 
    MEIS1ENSP000002723694STRING: ENSP00000272369
    MEIS2ENSP000003262964STRING: ENSP00000326296
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS10037736

    Find genes that share ontologies with NFE2L3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFE2L3 (NF2L3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NFE2L3 gene: 
    NM_004289.6  

    Unigene Cluster for NFE2L3:

    Nuclear factor (erythroid-derived 2)-like 3
    Hs.404741  [show with all ESTs]
    Unigene Representative Sequence: NM_004289
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000056233(uc003sxq.3) ENST00000607375 ENST00000606261
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NFE2L3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NFE2L3:
    hsa-miR-26a hsa-miR-33b hsa-miR-4282 hsa-miR-26b hsa-miR-33a hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidNFE2L3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NFE2L3
    Predesigned siRNA for gene silencing in human, mouse, rat NFE2L3
    Clone
    Products:
         
    OriGene clones in human, mouse for NFE2L3 (see all 7)
    OriGene ORF clones in mouse, rat for NFE2L3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NFE2L3 (NM_004289)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFE2L3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NFE2L3
    OriGene qSTAR qPCR primer pairs in human, mouse for NFE2L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFE2L3
      QuantiTect SYBR Green Assays in human, mouse, rat NFE2L3
      QuantiFast Probe-based Assays in human, mouse, rat NFE2L3

    Additional mRNA sequence: 

    AB010812.1 AF125534.1 AF133059.1 AF134891.1 BC015336.1 BC035762.1 BC049219.1 BC056142.1 
    BC068455.1 

    5 DOTS entries:

    DT.453116  DT.100790432  DT.100840048  DT.100653634  DT.101958724 

    Selected AceView cDNA sequences (see all 132):

    AV702287 BC015336 AA331415 CB143926 AA045573 BM771020 AA962733 AI865366 
    AI919099 CB160493 BG178514 AI621283 BM142211 BF589057 AB010812 AF134891 
    BM784805 BC068455 NM_004289 BX396198 AA501998 BM770806 BI761565 CB161133 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NFE2L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACCCAGT
    NFE2L3 Expression
    About this image


    NFE2L3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    NFE2L3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFE2L3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404741

    UniProtKB/Swiss-Prot: NF2L3_HUMAN, Q9Y4A8
    Tissue specificity: Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression
    in heart, brain, lung, skeletal muscle, kidney and pancreas

        Custom PCR Arrays for NFE2L3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NFE2L3
    OriGene qSTAR qPCR primer pairs in human, mouse for NFE2L3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFE2L3
    QuantiTect SYBR Green Assays in human, mouse, rat NFE2L3
    QuantiFast Probe-based Assays in human, mouse, rat NFE2L3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NFE2L3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfe2l31 , 5 nuclear factor, erythroid derived 2, like 31, 5 77.49(n)1
    69.82(a)1
      6 (24.84 cM)5
    180251  NM_010903.11  NP_035033.11 
     514326705 
    lizard
    (Anolis carolinensis)
    Reptilia NFE2L36
    nuclear factor, erythroid 2-like 3
    46(a)
    1 ↔ 1
    6(31847527-31848558)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171622 Transcribed sequence with weak similarity to protein more 71.6(n)    142021309 
    zebrafish
    (Danio rerio)
    Actinopterygii nfe2l36
    nuclear factor (erythroid-derived 2)-like 3
    29(a)
    1 ↔ 1
    19(20278282-20287096) ENSDARG00000019810
    fruit fly
    (Drosophila melanogaster)
    Insecta cnc3 blastoderm segmentation transcription
    factor
    48(a)     --


    ENSEMBL Gene Tree for NFE2L3 (if available)
    TreeFam Gene Tree for NFE2L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NFE2L3 gene
    BACH22  BACH12  NFE2L12  NFE22  NFE2L22  
    3 SIMAP similar genes for NFE2L3 using alignment to 3 protein entries:     NF2L3_HUMAN (see all proteins):
    NFE2    NFE2L1    FLJ00380

    Find genes that share paralogs with NFE2L3           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for NFE2L3
    PGOHUM00000248159 PGOHUM00000249118 PGOHUM00000237425 PGOHUM00000235077


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NFE2L3 (see all 838)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869832101,2
    --26189866(+) TGCTTA/TTGAAG 1 -- us2k10--------
    rs1894848811,2
    --26189900(+) CACTAC/TGATTA 1 -- us2k10--------
    rs1409826481,2
    --26190034(+) CAATTC/TAACTA 1 -- us2k10--------
    rs47225871,2
    C,F,H--26190086(+) GCACCA/GCCTTG 1 -- us2k122Minor allele frequency- G:0.03NS EA NA WA CSA 1593
    rs132286461,2
    C,F,H--26190193(+) TTCTCT/CTGTTT 1 -- us2k1 tfbs323Minor allele frequency- C:0.30NS EA NA WA 2754
    rs1807314851,2
    --26190267(+) AACTCC/TGTTTC 1 -- us2k10--------
    rs559700001,2
    C--26190344(+) CATTTA/CCTAAG 1 -- us2k10--------
    rs1464932661,2
    --26190446(+) CCAACC/TCATCT 1 -- us2k10--------
    rs37576731,2
    C,F,H--26190616(-) GGGCAG/CTTGTG 1 -- us2k16Minor allele frequency- C:0.07EA NS 2028
    rs744606701,2
    C--26190652(+) TCCCCT/CTTTCT 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for NFE2L3 (26191847 - 26226757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NFE2L3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734156CNV Deletion23290073
    esv2671129CNV Deletion23128226
    esv2659850CNV Deletion23128226
    esv1335165CNV Deletion17803354
    esv1600800CNV Insertion17803354
    esv22494CNV Loss19812545
    nsv887849CNV Gain21882294
    nsv7393OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFE2L3
    DNA2.0 Custom Variant and Variant Library Synthesis for NFE2L3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604135    OMIM disorders: --

    1 disease for NFE2L3:    
    About MalaCards
    fibrosarcoma


    Find genes that share disorders with NFE2L3           About GenesLikeMe

    Genetic Association Database (GAD): NFE2L3
    Human Genome Epidemiology (HuGE) Navigator: NFE2L3 (7 documents)

    Export disorders for NFE2L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NFE2L3 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with NFE2L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (PubMed id 10037736)1, 2, 3, 9 Kobayashi A.... Yamamoto M. (J. Biol. Chem. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Functional and placental expression analysis of the human NRF3 transcription factor. (PubMed id 15388789)1, 9 ChAcnais B....Blank V. (Mol. Endocrinol. 2005)
    7. Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor. (PubMed id 17976382)1, 9 Nouhi Z....Blank V. (FEBS Lett. 2007)
    8. Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin. (PubMed id 11286316)1, 9 Terui K....Ito E. (Tohoku J. Exp. Med. 2000)
    9. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. (PubMed id 23583978)1 Monda K.L....Haiman C.A. (Nat. Genet. 2013)
    10. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (Science 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9603 HGNC: 7783 AceView: NFE2L3 Ensembl:ENSG00000050344 euGenes: HUgn9603
    ECgene: NFE2L3 H-InvDB: NFE2L3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NFE2L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NFE2L3 gene:
    Search GeneIP for patents involving NFE2L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NFE2L3   OriGene RNAi products in human, mouse, rat for NFE2L3  
     OriGene qPCR primer pairs and template standards for NFE2L3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NFE2L3  
     OriGene qSTAR qPCR primer pairs in human, mouse for NFE2L3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NFE2L3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NFE2L3   OriGene Custom Protein Services for NFE2L3  

     
     
     Block miRNA regulation of human, mouse, rat NFE2L3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NFE2L3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFE2L3 Predesigned siRNA for gene silencing in human, mouse, rat NFE2L3
     QuantiFast Probe-based Assays in human, mouse, rat NFE2L3 QuantiTect SYBR Green Assays in human, mouse, rat NFE2L3
     Custom PCR Arrays for NFE2L3 Search Chromatin IP Primers for NFE2L3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFE2L3  GeneGlobe Interaction Network for NFE2L3
     Regulatory tfbs in NFE2L3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NFE2L3 GenScript cDNA clones with any tag delivered in your preferred vector for NFE2L3
     GenScript Custom Assay Services for NFE2L3 GenScript Custom overexpressing Cell Line Services for NFE2L3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NFE2L3 (NF2L3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NFE2L3 antibodies
     NFE2L3 proteins
     Antibodies for NFE2L3
     See all of Abcam's Antibodies, Kits and Proteins for NFE2L3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NFE2L3
     Antibodies for NFE2L3
     ELISAs for NFE2L3
     CLIAs for NFE2L3



     Browse ESI BIO Cell Lines and PureStem Progenitors for NFE2L3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L3
     SwitchGear 3'UTR luciferase reporter plasmids for NFE2L3
     Browse SwitchGear Promoter luciferase reporter plasmids for NFE2L3
     Search ThermoFisher Antibodies for NFE2L3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L3
     Browse compounds at ApexBio
     Search Addgene for plasmids for NFE2L3
      Search eBioscience for proteins for NFE2L3
      Search eBioscience for elisas for NFE2L3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for NFE2L3
     antibodies-online antibodies for NFE2L3 (21 products)
     antibodies-online kits for NFE2L3 (4 products)
     antibodies-online peptides for NFE2L3
     antibodies-online proteins for NFE2L3 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NFE2L3 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4