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Aliases for NFE2L3 Gene

Aliases for NFE2L3 Gene

  • Nuclear Factor, Erythroid 2 Like 3 2 3 5
  • Nuclear Factor, Erythroid Derived 2, Like 3 3 4
  • NF-E2-Related Factor 3 3 4
  • NFE2-Related Factor 3 3 4
  • NRF3 3 4
  • Nuclear Factor-Erythroid 2 P45-Related Factor 3 3
  • Nuclear Factor (Erythroid-Derived 2)-Like 3 2
  • Nuclear Factor Erythroid 2-Related Factor 3 3
  • Nuclear Factor, Erythroid 2-Like 3 2

External Ids for NFE2L3 Gene

Previous GeneCards Identifiers for NFE2L3 Gene

  • GC07P025834
  • GC07P025934
  • GC07P025965
  • GC07P026158
  • GC07P026191

Summaries for NFE2L3 Gene

Entrez Gene Summary for NFE2L3 Gene

  • This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

GeneCards Summary for NFE2L3 Gene

NFE2L3 (Nuclear Factor, Erythroid 2 Like 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is NFE2L1.

UniProtKB/Swiss-Prot for NFE2L3 Gene

  • Activates erythroid-specific, globin gene expression.

Gene Wiki entry for NFE2L3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFE2L3 Gene

Genomics for NFE2L3 Gene

Regulatory Elements for NFE2L3 Gene

Enhancers for NFE2L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G026180 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +28.8 28794 0.8 HDAC1 HDGF PKNOX1 ATF1 TBL1XR1 ARNT TCF12 ZNF766 GATA2 ELK1 NFE2L3 CBX3 GC07M026184 GC07P026176
GH07G025892 1.3 Ensembl ENCODE 10.7 -258.0 -257982 3.6 PKNOX1 FOXA2 WRNIP1 YY1 ETS1 ELK1 ZNF143 DEK SP3 YY2 MIR148A NFE2L3 LOC100506236 LOC105375200
GH07G026096 1.1 Ensembl ENCODE 11.8 -54.7 -54709 1.5 KLF1 ZSCAN18 PKNOX1 ZBTB21 BACH1 CEBPG ZFHX2 ZNF316 EGR1 PRDM10 NFE2L3 CBX3 HNRNPA2B1 LOC105375198 GC07P026071
GH07G026078 1.1 Ensembl ENCODE 11.3 -73.1 -73081 0.5 PKNOX1 ATF1 RB1 RAD21 EGR1 ZSCAN5C ZNF143 THAP11 EGR2 REST NFE2L3 CBX3 HNRNPA2B1 LOC105375304 GC07P026071 LOC105375198
GH07G026090 1 Ensembl ENCODE 12.3 -61.2 -61191 0.9 CTCF CEBPG ZNF384 ZIC2 RAD21 ZNF366 ZSCAN5C SMC3 EZH2 ZNF362 NFE2L3 HNRNPA2B1 CBX3 LOC105375198 GC07P026071
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFE2L3 on UCSC Golden Path with GeneCards custom track

Promoters for NFE2L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209740 373 1201 HDGF SIN3A ZNF766 ZNF143 PAF1 SP5 ZNF518A ZNF592 SMARCA4 CTCF

Genomic Location for NFE2L3 Gene

26,152,227 bp from pter
26,187,137 bp from pter
34,911 bases
Plus strand

Genomic View for NFE2L3 Gene

Genes around NFE2L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFE2L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFE2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFE2L3 Gene

Proteins for NFE2L3 Gene

  • Protein details for NFE2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear factor erythroid 2-related factor 3
    Protein Accession:
    Secondary Accessions:
    • Q6NUS0
    • Q7Z498
    • Q86UJ4
    • Q86VR5
    • Q9UQA4

    Protein attributes for NFE2L3 Gene

    694 amino acids
    Molecular mass:
    76154 Da
    Quaternary structure:
    • Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
    • Sequence=AAP22344.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA76288.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NFE2L3 Gene

Post-translational modifications for NFE2L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFE2L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NFE2L3 Gene

Domains & Families for NFE2L3 Gene

Gene Families for NFE2L3 Gene

Protein Domains for NFE2L3 Gene

Suggested Antigen Peptide Sequences for NFE2L3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bZIP family. CNC subfamily.
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with NFE2L3: view

Function for NFE2L3 Gene

Molecular function for NFE2L3 Gene

GENATLAS Biochemistry:
nuclear factor (erythroid-derived 2)-like 3,Capncollar (CNC) family of transcription factor,highly expressed in placenta,B cell and monocyte lineage
UniProtKB/Swiss-Prot Function:
Activates erythroid-specific, globin gene expression.

Gene Ontology (GO) - Molecular Function for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS,IEA 10037736
genes like me logo Genes that share ontologies with NFE2L3: view
genes like me logo Genes that share phenotypes with NFE2L3: view

Animal Models for NFE2L3 Gene

MGI Knock Outs for NFE2L3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NFE2L3 Gene

Localization for NFE2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFE2L3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFE2L3 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with NFE2L3: view

Pathways & Interactions for NFE2L3 Gene

SuperPathways for NFE2L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10037736
genes like me logo Genes that share ontologies with NFE2L3: view

No data available for Pathways by source and SIGNOR curated interactions for NFE2L3 Gene

Drugs & Compounds for NFE2L3 Gene

No Compound Related Data Available

Transcripts for NFE2L3 Gene

mRNA/cDNA for NFE2L3 Gene

Unigene Clusters for NFE2L3 Gene

Nuclear factor (erythroid-derived 2)-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L3 Gene

No ASD Table

Relevant External Links for NFE2L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFE2L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFE2L3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NFE2L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NFE2L3 Gene:


SOURCE GeneReport for Unigene cluster for NFE2L3 Gene:


mRNA Expression by UniProt/SwissProt for NFE2L3 Gene:

Tissue specificity: Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for NFE2L3 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with NFE2L3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFE2L3 Gene

Orthologs for NFE2L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFE2L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NFE2L3 34 35
  • 98.99 (n)
(Canis familiaris)
Mammalia NFE2L3 35 34
  • 83.52 (n)
(Bos Taurus)
Mammalia NFE2L3 34 35
  • 83.5 (n)
(Mus musculus)
Mammalia Nfe2l3 34 16 35
  • 77.49 (n)
(Rattus norvegicus)
Mammalia Nfe2l3 34
  • 76.32 (n)
(Ornithorhynchus anatinus)
Mammalia NFE2L3 35
  • 58 (a)
(Anolis carolinensis)
Reptilia NFE2L3 35
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nfe2l3 34
  • 56.25 (n)
Str.17162 34
(Danio rerio)
Actinopterygii nfe2l3 35
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta cnc 36 35
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
Species where no ortholog for NFE2L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFE2L3 Gene

Gene Tree for NFE2L3 (if available)
Gene Tree for NFE2L3 (if available)

Paralogs for NFE2L3 Gene

Paralogs for NFE2L3 Gene

(3) SIMAP similar genes for NFE2L3 Gene using alignment to 3 proteins: Pseudogenes for NFE2L3 Gene

genes like me logo Genes that share paralogs with NFE2L3: view

Variants for NFE2L3 Gene

Sequence variations from dbSNP and Humsavar for NFE2L3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000014363 -- 26,187,415(+) ATGCT(G/T)AAGTG downstream-variant-500B
rs1000028102 -- 26,172,226(+) TGCCT(C/T)AGCCA intron-variant
rs1000159250 -- 26,185,838(+) CTGAT(C/T)ATTTG utr-variant-3-prime
rs1000185130 -- 26,175,225(+) CGTGG(G/T)GGCAG intron-variant
rs1000427915 -- 26,150,439(+) CATCA(A/G)CTGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NFE2L3 Gene

Variant ID Type Subtype PubMed ID
dgv1877e212 CNV gain 25503493
esv1335165 CNV deletion 17803354
esv1600800 CNV insertion 17803354
esv22494 CNV loss 19812545
esv2659850 CNV deletion 23128226
esv2671129 CNV deletion 23128226
esv2734156 CNV deletion 23290073
esv3541363 CNV deletion 23714750
esv3541364 CNV deletion 23714750
esv3612615 CNV gain 21293372
esv3612621 CNV gain 21293372
esv3612626 CNV gain 21293372
esv3612627 CNV loss 21293372
esv3612628 CNV loss 21293372
esv3612629 CNV loss 21293372
esv3612631 CNV loss 21293372
esv3891090 CNV gain 25118596
nsv1028727 CNV gain 25217958
nsv1034358 CNV gain 25217958
nsv1074081 CNV deletion 25765185
nsv1076879 CNV deletion 25765185
nsv1145127 CNV deletion 24896259
nsv606432 CNV gain 21841781
nsv7393 OTHER inversion 18451855
nsv970807 CNV duplication 23825009

Variation tolerance for NFE2L3 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFE2L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFE2L3 Gene

Disorders for NFE2L3 Gene

Relevant External Links for NFE2L3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NFE2L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFE2L3 Gene

Publications for NFE2L3 Gene

  1. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (PMID: 10037736) Kobayashi A. … Yamamoto M. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor. (PMID: 17976382) Nouhi Z. … Blank V. (FEBS Lett. 2007) 3 22 64
  5. Functional and placental expression analysis of the human NRF3 transcription factor. (PMID: 15388789) ChAcnais B. … Blank V. (Mol. Endocrinol. 2005) 3 22 64

Products for NFE2L3 Gene

Sources for NFE2L3 Gene

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