NFE2L2 Gene
protein-coding GIFtS : 66 GCID: GC02 M178092
Nuclear Factor, Erythroid 2-Like 2 nuclear factor (erythroid-derived 2)-like 2 )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor NFE2L2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Nuclear Factor, Erythroid 2-Like 2 1 2 HEBP12 3 NF-E2-Related Factor 21 2 3 NFE2-Related Factor 22 3 NRF22 3 5 Nuclear Factor Erythroid 2-Related Factor 22 Nuclear Factor (Erythroid-Derived 2)-Like 21 2 Nuclear Factor Erythroid-Derived 2-Like 22 Nuclear Factor, Erythroid Derived 2, Like 22 3
External Ids: HGNC: 7782 1 Entrez Gene: 4780 2 Ensembl: ENSG00000116044 7 OMIM: 600492 5 UniProtKB: Q16236 3 Export aliases for NFE2L2 gene to outside databases Previous GC identifers: GC02M176157 GC02M176766 GC02M178059 GC02M178297 GC02M177920 GC02M177803 GC02M169966
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor NFE2L2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for NFE2L2 Gene: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012) GeneCards Summary for NFE2L2 Gene: NFE2L2 (nuclear factor, erythroid 2-like 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NFE2L2 include papillary adenocarcinoma hepatoblastoma sequence-specific DNA binding transcription factor activity and protein domain specific binding . An important paralog of this gene is BACH2 . UniProtKB/Swiss-Prot: NF2L2_HUMAN, Q16236 Function : Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of targetgenes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region Gene Wiki entry for NFE2L2 Gene
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor NFE2L2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NT_005403.17 NC_018913.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NFE2L2 gene promoter:SRY AML1a PPAR-gamma2 NF-kappaB1 Evi-1 C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for NFE2L2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q31 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31 NFE2L2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M178092: view genomic region
(about GC identifiers )
Start: 178,092,323 bp from pter End:
178,257,425 bp from pter
Size: 165,103 bases Orientation:
minus strand
ORGUL member locations:Legend (see complete legend)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor NFE2L2 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: NF2L2_HUMAN, Q16236 See
protein sequence )Recommended Name: Size : 605 amino acids; 67827 DaSubunit : Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts viaits leucine-zipper domain with the coiled-coil domain of PMF1. Interacts with EEF1D at heat shock promoter elements (HSE)
Subcellular location : Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into thenucleus upon induction by electrophilic agents
Sequence caution : Sequence=AAB32188.1; Type=Erroneous initiation; Sequence=BAD92023.1; Type=Erroneous initiation;3 PDB 3D structures from :2FLU (3D) 2LZ1 (3D) 3ZGC (3D) Secondary accessions : B2RBU2 B4E338 E9PGJ7 Q53RW6 Q59HH2 Q96F71Alternative splicing : 3 isoforms : Q16236-1 Q16236-2 Q16236-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NFE2L2: NX_Q16236 Explore proteomics data for NFE2L2 at MOPED Post-translational modifications:
UniProtKB: Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus (By similarity)
UniProtKB: Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence
UniProtKB: Ubiquitinated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and subject to proteasomal degradation. Ubiquitination is inhibited by sulforaphane
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q16236 NFE2L2 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (3 alternative transcripts): NP_001138884.1 NP_001138885.1 NP_006155.2 ENSEMBL proteins: ENSP00000416308 ENSP00000380253 ENSP00000380252 ENSP00000411575 ENSP00000467401 ENSP00000391590 ENSP00000400073 ENSP00000391291 ENSP00000464920 ENSP00000412191 ENSP00000410015 ENSP00000468089 Human Recombinant Protein Products for NFE2L2: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing NFE2L2 Antibody Products: Assay Products for NFE2L2:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for NFE2L2 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: bZIP: basic leucine zipper proteins 2 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry Q16236 ProtoNet protein and cluster: Q16236
1 Blocks protein domain : IPB011616 UniProtKB/Swiss-Prot: NF2L2_HUMAN, Q16236 Domain : Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminusSimilarity : Belongs to the bZIP family. CNC subfamilySimilarity : Contains 1 bZIP (basic-leucine zipper) domainAbout GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor NFE2L2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: NF2L2_HUMAN, Q16236 Function : Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of targetgenes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region Induction : Down-regulated by ENC1 via a proteasomal ubiquitin-independent protein catabolic process
Genatlas biochemistry entry for NFE2L2 nuclear factor,erythroid derived 2-like 2,Cap'n'collar (CNC) family of transcription factor,NF-E2-like Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing Phenotypes: 15/18 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nfe2l2) (see all 18 ):About GeneDecksing Animal Models: Nfe2l2 tm1Ney Nfe2l2 tm1Ywk In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L2
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor NFE2L2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for NFE2L2 About (see all 6 ) See pathways by source SuperPath Contained pathways About 1 Selenium Metabolism and Selenoproteins 2 Protein processing in endoplasmic reticulum 3 Oxidative Stress 4 Keap1-Nrf2 Pathway 5 AhR pathway
Pathways by source See SuperPaths Show all pathways 1 4 1 (Kegg details for NFE2L2) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFE2L2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/53 Interacting proteins for NFE2L2 (Q16236 2 , 3 ENSP00000380252 4 via UniProtKB, MINT, STRING , and/or I2D (see all 53 )About this table Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20 ): About this table
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor NFE2L2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for NFE2L2 (NF2L2) 10/92 Novoseek inferred chemical compound relationships for NFE2L2 gene (see all 92 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tbhq
93.4
106
20175231 (6), 17048120 (5), 18417180 (3), 15988009 (3) (see
all 30 )
sulforaphane
89.4
70
18633117 (4), 20175231 (4), 18417180 (3), 15826493 (3) (see
all 26 )
gamma-glutamylcysteine
79.2
11
19236154 (1), 11909699 (1), 17158454 (1), 16631525 (1) (see
all 9 )
oltipraz
72.2
18
18474683 (4), 16714377 (3), 19821532 (2), 15870285 (1)
n acetylcysteine
70.8
28
20384467 (2), 17142801 (1), 11909699 (1), 18928848 (1) (see
all 16 )
androstane
66.2
3
16399343 (1), 16837569 (1), 15858847 (1)
oxygen
63.7
47
19734219 (2), 17142801 (1), 17266519 (1), 17822364 (1) (see
all 32 )
15-deoxy-delta-12,14-prostaglandin j2
63.6
16
19723058 (3), 18775681 (2), 20064636 (2), 16987499 (1) (see
all 7 )
cobalt protoporphyrin
61.2
1
17065227 (1)
xanthohumol
60.2
1
16097803 (1)
NFE2L2 / NF2L2
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor NFE2L2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NFE2L2 gene (3 alternative transcripts): NM_001145412.2 NM_001145413.2 NM_006164.4 Unigene Cluster for NFE2L2:
Nuclear factor (erythroid-derived 2)-like 2 Hs.744006 [show with all ESTs ] Unigene Representative Sequence: NM_006164 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000458603 ENST00000397063 (uc002ulg.4 uc010zfa.2 ) ENST00000397062 (uc002ulh.4 )ENST00000446151 ENST00000464747 (uc002uli.4 ) ENST00000449627 ENST00000448782 ENST00000430047 ENST00000586532 ENST00000421929 ENST00000423513 (uc010fra.3 )ENST00000588123 ENST00000477534 (uc010frb.3 ) ENST00000462023 Primer NFE2L2 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB208786.1 AF323119.1 AK297838.1 AK304555.1 AK310656.1 AK310841.1 AK311395.1 AK311688.1 AK314816.1 AK316148.1 BC011558.1 BX649047.1 BX649071.1 HM446346.1 S74017.1
24/30 DOTS entries (see all 30 ): DT.100883523 DT.70103701
DT.121021385 DT.92448189 DT.95288997 DT.99990806 DT.121021487 DT.101984362 DT.454685 DT.121021480 DT.100883517 DT.121021362 DT.121021367 DT.91814259 DT.97794292 DT.121021624 DT.100736441 DT.100821389 DT.121021455 DT.40195544 DT.92448191 DT.92448194 DT.100001108 DT.121021506 24/629 AceView cDNA sequences (see all 629 ):
BG572345 CA444633 AI283937 BU902220 BM726340 BM013970 AI572307 AU135757 AW512933 W45505 BM978416 Z38956 BQ268118 CB850527 CB121882 BE079463 CB268651 CB850991 AW296144 BQ898215 AU185335 BG292004 CB116807 AA032072 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L2 (see all 13 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ SP1 : - - - - - - SP2 : - - - - - - - - SP3 : - - - - - - - - SP4 : SP5 :
ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b SP1 : SP2 : SP3 : SP4 : SP5 : -
ECgene alternative splicing isoforms for NFE2L2
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for NFE2L2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NFE2L2 expression in normal human tissues
(normalized intensities) NFE2L2 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: CTACGTGATGAbout this image
NFE2L2 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/12 selected tissues (see all 12 ) fully expand See NFE2L2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NFE2L2 SOURCE GeneReport for Unigene cluster: Hs.744006 UniProtKB/Swiss-Prot: NF2L2_HUMAN, Q16236 Tissue specificity : Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscleSABiosciences Custom PCR Arrays for NFE2L2 Primer NFE2L2 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L2
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor NFE2L2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for NFE2L2 gene from 6/15 species (see all 15 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Nfe2l21 5
nuclear factor, erythroid derived 2, like 21, 5
83.36(n) 1 82.52(a) 1
2 (44.75 cM) 5 18024 1 NM_010902.3 1 NP_035032.1 1 75675513 5
chicken Aves NFE2L21
nuclear factor (erythroid-derived 2)-like 2
72.56(n) 67.42(a)
396014 NM_205117.1 NP_990448.1
lizard Reptilia NFE2L26
Uncharacterized protein
60(a)
1 ↔ 1
GL343411.1(494162-534175)
African clawed frog Amphibia BC043997.12
--
73.41(n)
BC043997.1
zebrafish Actinopterygii BC045852.12
--
71.97(n)
360149 BC045852.1
fruit fly Insecta cnc3
blastoderm segmentation transcription factor
50(a)
--
ENSEMBL Gene Tree for NFE2L2 (if available)TreeFam Gene Tree for NFE2L2 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor NFE2L2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NFE2L2 gene BACH2 2 NFE2L3 2 BACH1 2 NFE2L1 2 NFE2 2 2 SIMAP similar genes for NFE2L2 using alignment to 10 protein entries: NF2L2_HUMAN (see all proteins ):NFE2L1 FLJ00380 About GeneDecksing 1 Pseudogenes.org Pseudogene for NFE2L2 PGOHUM00000240273
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor NFE2L2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 2 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for NFE2L2 (178092323 - 178257425 bp)
Structural Variations Database of Genomic Variants (DGV) 1 variation for NFE2L2 : About this table Human Gene Mutation Database (HGMD) : NFE2L2 5/19 SABiosciences Cancer Mutation PCR Assays for NFE2L2 (see all 19 ):
QIAGEN SeqTarget long-range PCR primers in human mouse rat
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor NFE2L2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 600492
OMIM disorders : --20/70 (see all 70 ): About MalaCards papillary adenocarcinoma hepatoblastoma traumatic brain injury friedreich ataxia gallbladder cancer peptic ulcer brain injury corneal dystrophy vascular disease venous thromboembolism vitiligo thromboembolism lung squamous cell carcinoma non-small cell lung carcinoma pulmonary fibrosis spinal cord injury idiopathic pulmonary fibrosis ependymoma ischemia chronic obstructive pulmonary disease 1 disease from the University of Copenhagen DISEASES database for NFE2L2 :Parkinson's disease Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/31 Novoseek inferred disease relationships for NFE2L2 gene (see all 31 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
cancer
47.9
72
18838122 (4), 18413364 (4), 19417020 (3), 19967722 (2) (see
all 40 )
neurodegenerative diseases
35.9
7
15469687 (1), 17145701 (1), 19573594 (1), 19082951 (1) (see
all 7 )
inflammation
32.1
13
19359988 (2), 16246346 (1), 16487040 (1), 17145701 (1) (see
all 7 )
cell damage
32
2
20405857 (1), 17980396 (1)
chemical carcinogenesis
27.1
1
16543142 (1)
vascular diseases
21.3
3
18633117 (1), 17263901 (1)
necrosis
19.8
7
17275675 (1), 17303087 (1), 17724089 (1), 18210237 (1) (see
all 6 )
colon cancer
18.7
7
19734940 (2), 19524433 (2), 16620709 (2), 19719968 (1)
atherosclerosis
16.1
3
15917255 (2)
chemically induced
15.3
3
17512459 (1), 20501860 (1)
Genetic Association Database (GAD): NFE2L2 Human Genome Epidemiology (HuGE) Navigator: NFE2L2 (23 documents) Export disorders for NFE2L2 gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor NFE2L2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NFE2L2 gene, integrated from 9 sources (see all 840 ):(articles sorted by number of sources associating them with NFE2L2) Utopia : connect your pdf to the dynamic
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF- E2/AP1 repeat of the beta-globin locus control region. (PubMed id 7937919) 1 , 2 , 3, 9(1994) NFE2L2 gene mutation in male Japanese squamous cell c arcinoma of the lung. (PubMed id 20421815) 1 , 4, 9(2010) Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PubMed id 19424503) 1 , 2 , 9(2009) Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. (PubMed id 11256947) 1 , 2 , 9(2001) Regulation of the antioxidant response element by protein kinase C- mediated phosphorylation of NF-E2-related factor 2. (PubMed id 11035812) 1 , 2 , 9(2000) Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. (PubMed id 16888629) 1 , 2 , 9(2006) PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. (PubMed id 18387606) 1 , 2 , 9(2008) Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer. (PubMed id 17726138) 1 , 4, 9(2007) Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. (PubMed id 15983046) 1 , 2 , 9(2005) Effect of NFE2L2 genetic polymorphism on the associat ion between oral estrogen therapy and the risk of venous thromboembolism in pos tmenopausal women. (PubMed id 21107315) 1 , 4(2011)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for NFE2L2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing NFE2L2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing NFE2L2 gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing NFE2L2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for NFE2L2 Pharmacogenomics, SNPs, Pathways
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for NFE2L2 gene: NFE2L2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor NFE2L2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFE2L2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for NFE2L2 (NRF2)
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L2
ThermoFisher Antibody for NFE2L2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NFE2L2
LSBio Antibodies in human mouse rat
Jump to Section...
Aliases for NFE2L2
Databases for NFE2L2
Disorders / Diseases for NFE2L2
Domains / Families for NFE2L2
Drugs / Compounds for NFE2L2
Expression for NFE2L2
Function for NFE2L2
Genomic Views for NFE2L2
Intellectual Property for NFE2L2
Orthologs for NFE2L2
Paralogs for NFE2L2
Pathways / Interactions for NFE2L2
Products for NFE2L2
Proteins for NFE2L2
Publications for NFE2L2
Search Box for NFE2L2
Summaries for NFE2L2
Transcripts for NFE2L2
Variants for NFE2L2
TOP
BOTTOM
GeneCards Homepage -
Last full update: 23 Oct 2013 -
Incrementals: 4 Nov 2013 , 7 Nov 2013
View Random Gene
Category
Protein-coding
RNA genes
Genetic Loci
Pseudogenes
Gene clusters
Uncategorized
Any
Go
transforming growth factor, beta 1
GIFtS Group
High
Medium
Low
Any
Developed at the Crown Human Genome Center Department of Molecular Genetics
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 106 solr: 1.4
and Proteopedia 
for NFE2L2:
Browse Tocris compounds for 
