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Aliases for NFE2L2 Gene

Aliases for NFE2L2 Gene

  • Nuclear Factor, Erythroid 2-Like 2 2 3
  • NF-E2-Related Factor 2 2 3 4
  • NRF2 3 4 6
  • Nuclear Factor (Erythroid-Derived 2)-Like 2 2 3
  • Nuclear Factor, Erythroid Derived 2, Like 2 3 4
  • NFE2-Related Factor 2 3 4
  • HEBP1 3 4
  • Nuclear Factor Erythroid 2-Related Factor 2 3
  • Nuclear Factor Erythroid-Derived 2-Like 2 3

External Ids for NFE2L2 Gene

Previous GeneCards Identifiers for NFE2L2 Gene

  • GC02M176157
  • GC02M176766
  • GC02M178059
  • GC02M178297
  • GC02M177920
  • GC02M177803
  • GC02M169966
  • GC02M178092

Summaries for NFE2L2 Gene

Entrez Gene Summary for NFE2L2 Gene

  • This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for NFE2L2 Gene

NFE2L2 (Nuclear Factor, Erythroid 2-Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for NFE2L2 Gene

  • Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Gene Wiki entry for NFE2L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFE2L2 Gene

Genomics for NFE2L2 Gene

Regulatory Elements for NFE2L2 Gene

Genomic Location for NFE2L2 Gene

Start:
177,227,595 bp from pter
End:
177,392,697 bp from pter
Size:
165,103 bases
Orientation:
Minus strand

Genomic View for NFE2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFE2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFE2L2 Gene

Proteins for NFE2L2 Gene

  • Protein details for NFE2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16236-NF2L2_HUMAN
    Recommended name:
    Nuclear factor erythroid 2-related factor 2
    Protein Accession:
    Q16236
    Secondary Accessions:
    • B2RBU2
    • B4E338
    • E9PGJ7
    • Q53RW6
    • Q59HH2
    • Q96F71

    Protein attributes for NFE2L2 Gene

    Size:
    605 amino acids
    Molecular mass:
    67827 Da
    Quaternary structure:
    • Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1. Interacts with EEF1D at heat shock promoter elements (HSE). Interacts (via the bZIP domain) with MAFK; required for binding to antioxidant response (ARE) elements on DNA. Interacts with CHD6; involved in activation of the transcription.
    SequenceCaution:
    • Sequence=AAB32188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92023.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFE2L2 Gene

    Alternative splice isoforms for NFE2L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFE2L2 Gene

Proteomics data for NFE2L2 Gene at MOPED

Post-translational modifications for NFE2L2 Gene

  • Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence.
  • Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
  • Ubiquitinated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and subject to proteasomal degradation. Ubiquitination is inhibited by sulforaphane.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFE2L2 Gene

Domains for NFE2L2 Gene

Gene Families for NFE2L2 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for NFE2L2 Gene

Suggested Antigen Peptide Sequences for NFE2L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16236

UniProtKB/Swiss-Prot:

NF2L2_HUMAN :
  • Q16236
Domain:
  • Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with NFE2L2: view

Function for NFE2L2 Gene

Molecular function for NFE2L2 Gene

GENATLAS Biochemistry: nuclear factor,erythroid derived 2-like 2,Capncollar (CNC) family of transcription factor,NF-E2-like
UniProtKB/Swiss-Prot Function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
UniProtKB/Swiss-Prot Induction: Down-regulated by ENC1 via a proteasomal ubiquitin-independent protein catabolic process

Gene Ontology (GO) - Molecular Function for NFE2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding TAS 24252804
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001102 RNA polymerase II activating transcription factor binding IPI 23043106
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001221 transcription cofactor binding IEA --
genes like me logo Genes that share ontologies with NFE2L2: view
genes like me logo Genes that share phenotypes with NFE2L2: view

Animal Models for NFE2L2 Gene

MGI Knock Outs for NFE2L2:
Targeting motifs for NFE2L2 Gene
HOMER Transcription Factor Regulatory Elements motif NFE2L2
  • Consensus sequence: HTGCTGAGTCAT Submotif: canonical Cell Type: Lymphoblast GeoId: GSE37589

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for NFE2L2 Gene

Localization for NFE2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFE2L2 Gene

Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFE2L2 Gene COMPARTMENTS Subcellular localization image for NFE2L2 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 4
plasma membrane 4
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NFE2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with NFE2L2: view

Pathways for NFE2L2 Gene

genes like me logo Genes that share pathways with NFE2L2: view

Pathways by source for NFE2L2 Gene

Gene Ontology (GO) - Biological Process for NFE2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 7937919
GO:0010499 proteasomal ubiquitin-independent protein catabolic process IDA 19424503
GO:0010628 positive regulation of gene expression IGI 22492997
GO:0016567 protein ubiquitination IDA 15983046
genes like me logo Genes that share ontologies with NFE2L2: view

Compounds for NFE2L2 Gene

(5) Tocris Compounds for NFE2L2 Gene

Compound Action Cas Number
AI-3 ARE activator; induces Nrf2-ARE-dependent transcription [882288-28-0]
Andrographolide Inhibits NFkappaB; blocks androgen receptor (AR) expression [5508-58-7]
Curcumin Antitumor, anti-inflammatory and antioxidant [458-37-7]
MMF Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512) [2756-87-8]
TAT 14 Nrf2 pathway activator; blocks Nrf2/Keap1 interaction [1362661-34-4]

(92) Novoseek inferred chemical compound relationships for NFE2L2 Gene

Compound -log(P) Hits PubMed IDs
tbhq 93.4 54
sulforaphane 89.4 46
gamma-glutamylcysteine 79.2 9
oltipraz 72.2 10
n acetylcysteine 70.8 17
genes like me logo Genes that share compounds with NFE2L2: view

Transcripts for NFE2L2 Gene

Unigene Clusters for NFE2L2 Gene

Nuclear factor (erythroid-derived 2)-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8:
SP9:
SP10: - - - - - - - -
SP11: -
SP12: -
SP13:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for NFE2L2 Gene

GeneLoc Exon Structure for
NFE2L2
ECgene alternative splicing isoforms for
NFE2L2

Expression for NFE2L2 Gene

mRNA expression in normal human tissues for NFE2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NFE2L2 Gene

SOURCE GeneReport for Unigene cluster for NFE2L2 Gene Hs.744006

mRNA Expression by UniProt/SwissProt for NFE2L2 Gene

Q16236-NF2L2_HUMAN
Tissue specificity: Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle
genes like me logo Genes that share expressions with NFE2L2: view

No data available for mRNA differential expression in normal tissues for NFE2L2 Gene

Orthologs for NFE2L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFE2L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFE2L2 35
  • 99.94 (n)
  • 99.83 (a)
NFE2L2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFE2L2 35
  • 90.45 (n)
  • 89.07 (a)
NFE2L2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFE2L2 35
  • 89.32 (n)
  • 88.81 (a)
NFE2L2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfe2l2 35
  • 83.36 (n)
  • 82.52 (a)
Nfe2l2 16
Nfe2l2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NFE2L2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFE2L2 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfe2l2 35
  • 83.75 (n)
  • 83.19 (a)
chicken
(Gallus gallus)
Aves NFE2L2 35
  • 72.44 (n)
  • 67.42 (a)
NFE2L2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFE2L2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfe2l2 35
  • 62.45 (n)
  • 54.77 (a)
Str.11814 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
nfe2l2a 35
  • 55.74 (n)
  • 51.91 (a)
nfe2l2a 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cnc 36
  • 11 (a)
OneToMany
cnc 37
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for NFE2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFE2L2 Gene

ENSEMBL:
Gene Tree for NFE2L2 (if available)
TreeFam:
Gene Tree for NFE2L2 (if available)

Paralogs for NFE2L2 Gene

Paralogs for NFE2L2 Gene

Selected SIMAP similar genes for NFE2L2 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for NFE2L2 Gene

genes like me logo Genes that share paralogs with NFE2L2: view

Variants for NFE2L2 Gene

Sequence variations from dbSNP and Humsavar for NFE2L2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1057044 -- 177,231,053(-) AAAAA(A/G)AAAAC missense, reference
rs1057092 -- 177,230,434(-) TAACC(A/C)CTATG utr-variant-3-prime
rs1057106 -- 177,230,350(-) AAAAA(A/G/T)TKTAA utr-variant-3-prime
rs1135118 -- 177,234,103(-) TTTTC(A/G)CTCAG missense, reference
rs1806649 -- 177,253,424(+) CTAAG(C/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFE2L2 Gene

Variant ID Type Subtype PubMed ID
nsv834465 CNV Loss 17160897

Relevant External Links for NFE2L2 Gene

HapMap Linkage Disequilibrium report
NFE2L2
Human Gene Mutation Database (HGMD)
NFE2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFE2L2 Gene

Disorders for NFE2L2 Gene

(1) University of Copenhagen DISEASES for NFE2L2 Gene

(31) Novoseek inferred disease relationships for NFE2L2 Gene

Disease -log(P) Hits PubMed IDs
cancer 47.9 55
neurodegenerative diseases 35.9 7
inflammation 32.1 8
cell damage 32 2
chemical carcinogenesis 27.1 1

Relevant External Links for NFE2L2

Genetic Association Database (GAD)
NFE2L2
Human Genome Epidemiology (HuGE) Navigator
NFE2L2
genes like me logo Genes that share disorders with NFE2L2: view

No data available for UniProtKB/Swiss-Prot for NFE2L2 Gene

Publications for NFE2L2 Gene

  1. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF- E2/AP1 repeat of the beta-globin locus control region. (PMID: 7937919) Moi P. … Kan Y.W. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Regulation of the antioxidant response element by protein kinase C- mediated phosphorylation of NF-E2-related factor 2. (PMID: 11035812) Huang H.-C. … Pickett C.B. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  3. Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. (PMID: 11256947) Wang Y. … Casero R.A. Jr. (Biochem. J. 2001) 3 4 23
  4. Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer. (PMID: 17726138) Hong C.C. … Calle E.E. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 23 48
  5. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PMID: 19424503) Wang X.J. … Zhang D.D. (PLoS ONE 2009) 3 4 23

Products for NFE2L2 Gene

Sources for NFE2L2 Gene

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