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Aliases for NFE2L2 Gene

Aliases for NFE2L2 Gene

  • Nuclear Factor, Erythroid 2-Like 2 2 3
  • NF-E2-Related Factor 2 2 4
  • HEBP1 3 4
  • NRF2 3 4
  • Nuclear Factor (Erythroid-Derived 2)-Like 2 2
  • Nuclear Factor, Erythroid Derived 2, Like 2 4
  • Nuclear Factor Erythroid-Derived 2-Like 2 3
  • NFE2-Related Factor 2 4

External Ids for NFE2L2 Gene

Previous GeneCards Identifiers for NFE2L2 Gene

  • GC02M176157
  • GC02M176766
  • GC02M178059
  • GC02M178297
  • GC02M177920
  • GC02M177803
  • GC02M169966
  • GC02M178092

Summaries for NFE2L2 Gene

Entrez Gene Summary for NFE2L2 Gene

  • This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for NFE2L2 Gene

NFE2L2 (Nuclear Factor, Erythroid 2-Like 2) is a Protein Coding gene. Diseases associated with NFE2L2 include lung papillary adenocarcinoma. Among its related pathways are Signaling by GPCR and AhR pathway (WikiPathways). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for NFE2L2 Gene

  • Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Gene Wiki entry for NFE2L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFE2L2 Gene

Genomics for NFE2L2 Gene

Regulatory Elements for NFE2L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFE2L2 Gene

Chromosome:
2
Start:
177,227,595 bp from pter
End:
177,392,697 bp from pter
Size:
165,103 bases
Orientation:
Minus strand

Genomic View for NFE2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFE2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFE2L2 Gene

Proteins for NFE2L2 Gene

  • Protein details for NFE2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16236-NF2L2_HUMAN
    Recommended name:
    Nuclear factor erythroid 2-related factor 2
    Protein Accession:
    Q16236
    Secondary Accessions:
    • B2RBU2
    • B4E338
    • E9PGJ7
    • Q53RW6
    • Q59HH2
    • Q96F71

    Protein attributes for NFE2L2 Gene

    Size:
    605 amino acids
    Molecular mass:
    67827 Da
    Quaternary structure:
    • Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1. Interacts with EEF1D at heat shock promoter elements (HSE). Interacts (via the bZIP domain) with MAFK; required for binding to antioxidant response (ARE) elements on DNA. Interacts with CHD6; involved in activation of the transcription.
    SequenceCaution:
    • Sequence=AAB32188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92023.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFE2L2 Gene

    Alternative splice isoforms for NFE2L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFE2L2 Gene

Proteomics data for NFE2L2 Gene at MOPED

Post-translational modifications for NFE2L2 Gene

  • Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence.
  • Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
  • Ubiquitinated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and subject to proteasomal degradation. Ubiquitination is inhibited by sulforaphane.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NFE2L2 Gene

Domains & Families for NFE2L2 Gene

Gene Families for NFE2L2 Gene

Protein Domains for NFE2L2 Gene

Suggested Antigen Peptide Sequences for NFE2L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16236

UniProtKB/Swiss-Prot:

NF2L2_HUMAN :
  • Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus
  • Belongs to the bZIP family. CNC subfamily.
Domain:
  • Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with NFE2L2: view

Function for NFE2L2 Gene

Molecular function for NFE2L2 Gene

GENATLAS Biochemistry:
nuclear factor,erythroid derived 2-like 2,Capncollar (CNC) family of transcription factor,NF-E2-like
UniProtKB/Swiss-Prot Function:
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
UniProtKB/Swiss-Prot Induction:
Down-regulated by ENC1 via a proteasomal ubiquitin-independent protein catabolic process

Gene Ontology (GO) - Molecular Function for NFE2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding TAS 24252804
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001102 RNA polymerase II activating transcription factor binding IPI 23043106
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003677 DNA binding IDA 18554677
genes like me logo Genes that share ontologies with NFE2L2: view
genes like me logo Genes that share phenotypes with NFE2L2: view

Animal Models for NFE2L2 Gene

MGI Knock Outs for NFE2L2:

Animal Model Products

CRISPR Products

Targeted motifs for NFE2L2 Gene
HOMER Transcription Factor Regulatory Elements motif NFE2L2
  • Consensus sequence: HTGCTGAGTCAT Submotif: canonical Cell Type: Lymphoblast GEO ID: GSE37589

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFE2L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for NFE2L2 Gene

Localization for NFE2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFE2L2 Gene

Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFE2L2 Gene COMPARTMENTS Subcellular localization image for NFE2L2 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 4
plasma membrane 4
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NFE2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 18202225
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 22492997
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with NFE2L2: view

Pathways & Interactions for NFE2L2 Gene

genes like me logo Genes that share pathways with NFE2L2: view

SIGNOR curated interactions for NFE2L2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NFE2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006954 inflammatory response IEA --
GO:0010499 proteasomal ubiquitin-independent protein catabolic process IDA 19424503
GO:0010628 positive regulation of gene expression IGI 22492997
genes like me logo Genes that share ontologies with NFE2L2: view

Drugs & Compounds for NFE2L2 Gene

(43) Drugs for NFE2L2 Gene - From: NovoSeek, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dimethyl fumarate Approved, Investigational Pharma 60
Apomorphine Approved, Investigational Pharma Activation, Activator 32
Chloramphenicol Approved Pharma 6
Dexamethasone Approved, Investigational Pharma Agonist 1806
Dicumarol Approved Pharma 0

(54) Additional Compounds for NFE2L2 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AI-3
882288-28-0
CDDO Im
443104-02-7
MMF
2756-87-8
TAT 14
1362661-34-4
12-O-Tetradecanoylphorbol 13-acetate
genes like me logo Genes that share compounds with NFE2L2: view

Transcripts for NFE2L2 Gene

Unigene Clusters for NFE2L2 Gene

Nuclear factor (erythroid-derived 2)-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFE2L2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8:
SP9:
SP10: - - - - - - - -
SP11: -
SP12: -
SP13:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for NFE2L2 Gene

GeneLoc Exon Structure for
NFE2L2
ECgene alternative splicing isoforms for
NFE2L2

Expression for NFE2L2 Gene

mRNA expression in normal human tissues for NFE2L2 Gene

Protein differential expression in normal tissues from HIPED for NFE2L2 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NFE2L2 Gene



SOURCE GeneReport for Unigene cluster for NFE2L2 Gene Hs.744006

mRNA Expression by UniProt/SwissProt for NFE2L2 Gene

Q16236-NF2L2_HUMAN
Tissue specificity: Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle
genes like me logo Genes that share expression patterns with NFE2L2: view

Protein tissue co-expression partners for NFE2L2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NFE2L2 Gene

Orthologs for NFE2L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFE2L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFE2L2 35
  • 90.45 (n)
  • 89.07 (a)
NFE2L2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFE2L2 35
  • 89.32 (n)
  • 88.81 (a)
NFE2L2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfe2l2 35
  • 83.36 (n)
  • 82.52 (a)
Nfe2l2 16
Nfe2l2 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFE2L2 35
  • 99.94 (n)
  • 99.83 (a)
NFE2L2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfe2l2 35
  • 83.75 (n)
  • 83.19 (a)
oppossum
(Monodelphis domestica)
Mammalia NFE2L2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFE2L2 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFE2L2 35
  • 72.44 (n)
  • 67.42 (a)
NFE2L2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFE2L2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfe2l2 35
  • 62.45 (n)
  • 54.77 (a)
Str.11814 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
nfe2l2a 35
  • 55.74 (n)
  • 51.91 (a)
nfe2l2a 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cnc 37
  • 50 (a)
cnc 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for NFE2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFE2L2 Gene

ENSEMBL:
Gene Tree for NFE2L2 (if available)
TreeFam:
Gene Tree for NFE2L2 (if available)

Paralogs for NFE2L2 Gene

Paralogs for NFE2L2 Gene

Pseudogenes.org Pseudogenes for NFE2L2 Gene

genes like me logo Genes that share paralogs with NFE2L2: view

Variants for NFE2L2 Gene

Sequence variations from dbSNP and Humsavar for NFE2L2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1057044 -- 177,231,053(-) AAAAA(A/G)AAAAC missense, reference
rs1057092 -- 177,230,434(-) TAACC(A/C)CTATG utr-variant-3-prime
rs1057106 -- 177,230,350(-) AAAAA(A/G/T)TKTAA utr-variant-3-prime
rs1135118 -- 177,234,103(-) TTTTC(A/G)CTCAG missense, reference
rs1806649 -- 177,253,424(+) CTAAG(C/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFE2L2 Gene

Variant ID Type Subtype PubMed ID
nsv834465 CNV Loss 17160897

Variation tolerance for NFE2L2 Gene

Residual Variation Intolerance Score: 58.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFE2L2 Gene

HapMap Linkage Disequilibrium report
NFE2L2
Human Gene Mutation Database (HGMD)
NFE2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFE2L2 Gene

Disorders for NFE2L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NFE2L2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lung papillary adenocarcinoma
  • papillary adenocarcinoma of the lung
- elite association

Relevant External Links for NFE2L2

Genetic Association Database (GAD)
NFE2L2
Human Genome Epidemiology (HuGE) Navigator
NFE2L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFE2L2
genes like me logo Genes that share disorders with NFE2L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NFE2L2 Gene

Publications for NFE2L2 Gene

  1. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF- E2/AP1 repeat of the beta-globin locus control region. (PMID: 7937919) Moi P. … Kan Y.W. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 23 67
  2. Effects of atmospheric pollutants on the Nrf2 survival pathway. (PMID: 19367423) Rubio V. … Rojas E. (Environ Sci Pollut Res Int 2010) 23 67
  3. Nrf2 signaling and cell survival. (PMID: 19538984) Niture S.K. … Jaiswal A.K. (Toxicol. Appl. Pharmacol. 2010) 23 67
  4. Targeting NRF2 signaling for cancer chemoprevention. (PMID: 19732782) Kwak M.K. … Kensler T.W. (Toxicol. Appl. Pharmacol. 2010) 23 67
  5. Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway. (PMID: 19889935) Burdette D. … Waris G. (J. Gen. Virol. 2010) 23 67

Products for NFE2L2 Gene

Sources for NFE2L2 Gene

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