NFE2L1 Gene
protein-coding GIFtS: 60
GCID: GC17P046125
|
|
nuclear factor (erythroid-derived 2)-like 1
(Previous symbol: TCF11)
| |
Aliases
for NFE2L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Factor (Erythroid-Derived 2)-Like 11 2 | | TCF-112 3 | | NRF11 2 3 5 | | NF-E2-Related Factor 12 3 | | TCF111 2 3 | | NFE2-Related Factor 12 3 | | LCR-F11 2 | | FLJ003801 | | Locus Control Region-Factor 12 3 | | Nuclear Factor Erythroid 2-Related Factor 12 | | Nuclear Factor, Erythroid Derived 2, Like 12 3 | | Transcription Factor 11 (Basic Leucine Zipper Type)2 | | Transcription Factor HBZ172 3 | | HBZ173 | | Transcription Factor LCR-F12 3 | | Transcription Factor 113 |
Export aliases for NFE2L1 gene to outside databasesPrevious GC identifers: GC17P045831 GC17P048606 GC17P046467 GC17P046600 GC17P043480 GC17P041494 |
Summaries
for NFE2L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NFE2L1:
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred inbibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1'which has an official symbol of NRF1. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NF2L1_HUMAN, Q14494Function: Activates erythroid-specific, globin gene expression
Gene Wiki entry for NFE2L1
|
Genomic Views
for NFE2L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NFE2L1 gene promoter:
Bach1 HEN1 AREB6 CBF-B CP1A Nkx2-5 CBF-C
Other transcription factors
Search SABiosciences Chromatin IP Primers for NFE2L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFE2L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.3 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.3NFE2L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P046125: view genomic region
(about GC identifiers)
Start:
|
46,125,686 bp from pter |
End:
|
46,138,907 bp from pter |
Size:
|
13,222 bases |
Orientation:
|
plus strand |
|
Proteins
for NFE2L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NF2L1_HUMAN, Q14494 (See
protein sequence)Recommended Name: Nuclear factor erythroid 2-related factor 1 Size: 772 amino acids; 84704 Da
Subunit: Interacts with KEAP1
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus
Secondary accessions: D3DTU3 D3DTU5 Q12877 Q96FN6Alternative splicing: 2 isoforms: Q14494-1 Q14494-2 Explore the universe of human proteins at neXtProt for NFE2L1: NX_Q14494
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14494
NFE2L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003195.1
ENSEMBL proteins: ENSP00000462003 ENSP00000463657 ENSP00000354855 ENSP00000461960 ENSP00000350072 ENSP00000355190 ENSP00000463960 ENSP00000462253 ENSP00000462444 ENSP00000464018 ENSP00000462610 ENSP00000462971 ENSP00000464203 ENSP00000464446 ENSP00000463291 ENSP00000445811 ENSP00000463836 ENSP00000463744 ENSP00000461971
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NFE2L1 for ontologies About GeneDecksing
NFE2L1 Antibody Products:
Assay Products for NFE2L1: |
Protein
Domains /
Families
for NFE2L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NFE2L1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14494ProtoNet protein and cluster: Q14494 1 Blocks protein family: IPB011616 bZIP transcription factor
UniProtKB/Swiss-Prot: NF2L1_HUMAN, Q14494Similarity: Belongs to the bZIP family. CNC subfamilySimilarity: Contains 1 bZIP (basic-leucine zipper) domain |
Function
for NFE2L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NF2L1_HUMAN, Q14494Function: Activates erythroid-specific, globin gene expression Genatlas biochemistry entry for NFE2L1:nuclear factor,erythroid derived 2-like 1,Cap'n'collar (CNC) family of transcription factor,expressed in many tissues
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NFE2L1 (NM_003204) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NFE2L1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0003712 | transcription cofactor activity |
TAS | 9826775 | | GO:0005515 | protein binding |
-- | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
-- | -- |
NFE2L1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for NFE2L1: Nfe2l1tm1Tow Nfe2l1tm1Ywk
10 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Nfe2l1):
NFE2L1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NFE2L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Human Embryonic Stem Cell Pluripotency | | | 2 | Rho Family GTPases | | | 3 | WNT Signaling | | | 4 | TGF-Beta Pathway | | | 5 | PAK Pathway | |
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFE2L1 (see all 7)
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFE2L1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/21 Interacting proteins for NFE2L1 (Q144943 ENSP000003551904) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
NFE2L1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NFE2L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NFE2L1 for compounds About GeneDecksing
 Browse Tocris compounds for NFE2L1
1 HMDB Compound for NFE2L1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
1 DrugBank Compound for NFE2L1 About this table
2 Novoseek chemical compound relationships for NFE2L1 gene About this table
Search CenterWatch for drugs/clinical trials and news about NFE2L1 / NF2L1
|
Transcripts
for NFE2L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NFE2L1 gene: NM_003204.2 Unigene Cluster for NFE2L1: Nuclear factor (erythroid-derived 2)-like 1 Hs.514284 [show with all ESTs]Unigene Representative Sequence: NM_00320418/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23): ENST00000579889 ENST00000584137 ENST00000362042(uc002imz.4 uc002inb.4)
ENST00000585291(uc002ina.4 uc010wle.2 uc010wlf.2) ENST00000357480
ENST00000585299 ENST00000583060 ENST00000361665(uc002inc.1) ENST00000579481
ENST00000582574 ENST00000585062 ENST00000581441 ENST00000579537 ENST00000583210
ENST00000577411 ENST00000584634 ENST00000580050 ENST00000582155
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NFE2L1 (NM_003204) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NFE2L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L1 |
Additional cDNA sequence: AK090459.1 AK294553.1 AK302387.1 AL833530.1 BC010623.1 BC131769.1 BX647976.1 U08853.1 X77366.1 24/27 DOTS entries (see all 27): DT.95202118 DT.100059535 DT.91780188 DT.95085851 DT.95267618 DT.121193319 DT.95202156 DT.100800340 DT.120931625 DT.120931679 DT.95202168 DT.120931606 DT.120931668 DT.97808495 DT.100826080 DT.100826082 DT.120931600 DT.120931604 DT.120931660 DT.120931682 DT.452928 DT.95068639 DT.95202109 DT.95261049 24/647 AceView cDNA sequences (see all 647): CD369283 BQ182406 AA954277 AJ708879 AU120634 BM694854 CD674397 AL698851 AA994564 BU737784 BM742171 BX641406 BM970334 BC010623 CN480917 BU616435 AA907282 BM742119 CF125091 AW275202 CA309979 F29791 BM565563 BM688732
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L1 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NFE2L1
|
Expression
for NFE2L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NFE2L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAAATAAA
About this image
See NFE2L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NFE2L1
SOURCE GeneReport for Unigene cluster: Hs.514284
SABiosciences Expression via Pathway-Focused PCR Array including NFE2L1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFE2L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NFE2L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFE2L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFE2L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L1 |
Orthologs
for NFE2L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NFE2L1 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NFE2L11 |
nuclear factor (erythroid-derived 2)-like 1 |
78.87(n)
83.9(a) |
|
417987 NM_001030756.1 NP_001025927.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NFE2L16 |
-- |
79(a) |
1 ↔ 1 |
6(74957332-74978690) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC689922 |
hypothetical protein MGC68992 |
73.16(n) |
|
BC059314.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5587721 |
nuclear factor erythroid 2-related factor 1-like |
64.24(n)
62.75(a) |
|
558772 XM_001920230.3 XP_001920265.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
cnc3 |
blastoderm segmentation transcription factor |
52(a) |
|
-- |
ENSEMBL Gene Tree for NFE2L1 (if available)
TreeFam Gene Tree for NFE2L1 (if available) |
Paralogs
for NFE2L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NFE2L1 gene
- NFE2L32 BACH22 BACH12 NFE22 NFE2L22
3 SIMAP similar genes for NFE2L1 using alignment to 16 protein entries: NF2L1_HUMAN (see all proteins):FLJ00380 NFE2L3 NFE2L2
NFE2L1 for paralogs About GeneDecksing
|
Genomic Variants
for NFE2L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NFE2L1 (46125686 - 46138907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NFE2L1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFE2L1 |
|
Disorders
/ Diseases
for NFE2L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NFE2L1 for disorders About GeneDecksing
OMIM gene information: 163260
OMIM disorders: --
6  diseases for NFE2L1: About MalaCardsuterine fibroid hepatitis b leiomyoma anemia
hepatitis hypoxia
1 disease from the University of Copenhagen DISEASES database for NFE2L1:Uterine fibroid Human Genome Epidemiology (HuGE) Navigator: NFE2L1 (1 document)
Export disorders for NFE2L1 gene to outside databases
|
Publications
for NFE2L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NFE2L1 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with NFE2L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. (PubMed id 8248256)1, 2, 3, 9 Chan J.Y.... Kan Y.W. (1993)
- Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. (PubMed id 16687406)1, 2, 9 Wang W. and Chan J.Y. (2006)
- Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression. (PubMed id 8036168)1, 2, 9 Caterina J.J.... Townes T.M. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. (PubMed id 9501099)1, 3 Chan J.Y....Kan Y.W. (1998)
- Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22. (PubMed id 8001966)1, 2 Luna L.... Kolstoe A.-B. (1994)
- Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. (PubMed id 8932385)1, 9 Johnsen O....Kolsto A.B. (1996)
- The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. (PubMed id 17609210)1, 9 Wang W....Chan J.Y. (2007)
- Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. (PubMed id 9872330)1, 9 Venugopal R. and Jaiswal A.K. (1998)
- Transcription factor Nrf1 mediates the proteasome rec overy pathway after proteasome inhibition in mammalian cells. (PubMed id 20385086)1, 9 Radhakrishnan S.K....Deshaies R.J. (2010)
|
External Searches for NFE2L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NFE2L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NFE2L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NFE2L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NFE2L1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NFE2L1 gene:
Search GeneIP for patents involving NFE2L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NFE2L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NFE2L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFE2L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFE2L1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NFE2L1 | | OriGene 3'-UTR Clone for NFE2L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFE2L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NFE2L1 | | OriGene Custom Protein Services for NFE2L1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFE2L1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFE2L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFE2L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFE2L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFE2L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFE2L1 |
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| | Antibodies & Assays for NFE2L1 |
| | | | Search Tocris compounds for NFE2L1 |
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 | | | NFE2L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFE2L1 |
|  |  |  | | | | ThermoFisher Antibodies for NFE2L1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFE2L1 |
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