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NFATC4 Gene

protein-coding   GIFtS: 61
GCID: GC14P024834

Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent
41 2
     NF-ATC42
NF-AT32 3     Nuclear Factor Of Activated T-Cells, Cytoplasmic 42
NFAT32 3     NF-ATc43
T-Cell Transcription Factor NFAT32 3     NFATc43

External Ids:    HGNC: 77781   Entrez Gene: 47762   Ensembl: ENSG000001009687   OMIM: 6026995   UniProtKB: Q149343   

Export aliases for NFATC4 gene to outside databases

Previous GC identifers: GC14P022209 GC14P018624 GC14P022827 GC14P023907 GC14P004950


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFATC4 Gene:
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein
is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting
cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear
component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein
plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of
interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Jan 2014)

GeneCards Summary for NFATC4 Gene:
NFATC4 (nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is NFATC3.

UniProtKB/Swiss-Prot: NFAC4_HUMAN, Q14934
Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of
the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by
estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May
play an important role in myotube differentiation. May play a critical role in cardiac development and
hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons

Gene Wiki entry for NFATC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFATC4 gene promoter:
         AML1a   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFATC4 promoter sequence
   Search Chromatin IP Primers for NFATC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFATC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

NFATC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFATC4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024834:  view genomic region     (about GC identifiers)

Start:
24,834,879 bp from pter      End:
24,848,810 bp from pter
Size:
13,932 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NFAC4_HUMAN, Q14934 (See protein sequence)
Recommended Name: Nuclear factor of activated T-cells, cytoplasmic 4  
Size: 902 amino acids; 95449 Da
Subunit: Member of the multicomponent NFATC transcription complex that consists of at least two components, a
pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as
NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex.
NFATC proteins bind to DNA as monomers. Interacts with CREBBP, GATA4, IRAK1, MAPK8, MAPK9 and RPS6KA3
1 PDB 3D structure from and Proteopedia for NFATC4:
2YRP (3D)    
Secondary accessions: B4DDG5 B4DY55 B5B2U7 B5B2U8 B5B2U9 B5B2V0 B5B2V1 B5B2V2 B5B2V3 B5B2V4
B5B2V5 B5B2V7 B5B2V8 B5B2V9 B5B2W0 B5B2W1 B5B2W2 B5B2W3 B5B2W4 B5B2W5 B5B2W6 B5B2W7 B5B2W8
B5B2W9 B5B2X0 Q7Z598 Q96H68
Alternative splicing: 24 isoforms:  Q14934-1   Q14934-2   Q14934-3   Q14934-4   Q14934-5   Q14934-6   Q14934-7   Q14934-8   
Q14934-9   Q14934-10   Q14934-11   Q14934-12   Q14934-13   Q14934-14   Q14934-15   Q14934-16   
Q14934-17   Q14934-18   Q14934-19   Q14934-20   Q14934-21   Q14934-22   Q14934-23   Q14934-24   
(Due to an intron retention)

Explore the universe of human proteins at neXtProt for NFATC4: NX_Q14934

Explore proteomics data for NFATC4 at MOPED

Post-translational modifications: 

  • Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR,
    IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3.
    Phosphorylated by GSK3B1
  • Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination
    and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation.
    Polyubiquitin linkage is mainly through 'Lys-48'1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFATC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001129494.1  NP_001185894.1  NP_001185895.1  NP_001185896.1  NP_001275731.1  NP_004545.2  

    ENSEMBL proteins: 
     ENSP00000388910   ENSP00000452039   ENSP00000451224   ENSP00000450644   ENSP00000388668  
     ENSP00000439350   ENSP00000452270   ENSP00000451502   ENSP00000451151   ENSP00000451853  
     ENSP00000451992   ENSP00000250373   ENSP00000450590   ENSP00000452352   ENSP00000452349  
     ENSP00000450469   ENSP00000450733   ENSP00000451454   ENSP00000451284   ENSP00000396788  
     ENSP00000450686   ENSP00000450810   ENSP00000451183   ENSP00000451395   ENSP00000451496  
     ENSP00000451801   ENSP00000451590  

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    antibodies-online proteins for NFATC4 (2 products) 

     
    antibodies-online peptides for NFATC4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NFAT: Nuclear factor of activated T-cells

    Selected InterPro protein domains (see all 7):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT
     IPR015647 NFAT1/4
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q14934

    ProtoNet protein and cluster: Q14934

    3 Blocks protein domains:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008366 Nuclear factor of activated T cells (NFAT) signature
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: NFAC4_HUMAN, Q14934
    Domain: Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By
    similarity)
    Similarity: Contains 1 IPT/TIG domain
    Similarity: Contains 1 RHD (Rel-like) domain


    Find genes that share domains with NFATC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFAC4_HUMAN, Q14934
    Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of
    the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by
    estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May
    play an important role in myotube differentiation. May play a critical role in cardiac development and
    hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003713transcription coactivator activity TAS7749981
    GO:0005515protein binding IPI19026640
         
    Find genes that share ontologies with NFATC4           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nfatc4):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  mortality/aging 
     muscle  nervous system  skeleton 

    Find genes that share phenotypes with NFATC4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NFATC4: Nfatc4tm1Grc Nfatc4tm1Jmk

       genOway: Develop your customized and physiologically relevant rodent model for NFATC4

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NFATC4 (see all 314):
    ACBD7,  ACER1,  ACOT12,  ACVR2A,  ADAD1,  ADAL,  ALDH1B1,  ANKRD22,  ANKRD30B,  ANKRD34C

    miRNA
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    hsa-miR-4291 hsa-miR-3607-3p hsa-miR-328 hsa-miR-4305 hsa-miR-29c hsa-miR-29a hsa-miR-486-3p hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmidNFATC4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NFATC4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): NFATC4 (NM_004554)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFATC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFATC4
    Addgene plasmids for NFATC4 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFATC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFAC4_HUMAN, Q14934: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after
    activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought
    to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular
    localization of NFATC plays a key role in the regulation of gene transcription
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3
    extracellular2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with NFATC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NFATC4 About   (see all 30)  
    See pathways by source

    SuperPathContained pathways About
    1fMLP Pathway
    fMLP Pathway0.43
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    4TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    ITK and TCR Signaling0.54
    TCR Signaling0.68
    Fc-EpsilonRI Pathway0.49
    5RANK Signaling in Osteoclasts
    APRIL Pathway0.92
    RANK Signaling in Osteoclasts0.45
    BAFF in B-Cell Signaling0.92


    Find genes that share SuperPaths with NFATC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for NFATC4
        Wnt Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NFATC4 (see all 30)
        PKA Signaling
    Intracellular Calcium Signaling
    NFAT Signaling and Lymphocyte Interactions
    PI3K Signaling in B-Lymphocyte
    IL-2 Pathway

    1 Cell Signaling Technology (CST) Pathway for NFATC4
        Lymphocyte Signaling

    5 GeneGo (Thomson Reuters) Pathways for NFATC4
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Immune response Fc epsilon RI pathway
    Immune response T cell receptor signaling pathway
    Immune response CD28 signaling
    Immune response NFAT in immune response

    5 BioSystems Pathways for NFATC4
        MicroRNAs in cardiomyocyte hypertrophy
    Heart Development
    BDNF signaling pathway
    Physiological and Pathological Hypertrophy of the Heart
    ErbB2/ErbB3 signaling events

    1 PharmGKB Pathway for NFATC4
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for NFATC4):
        Wnt signaling pathway
    Axon guidance
    Oxytocin signaling pathway
    Hepatitis B
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFATC4: 
              Stem Cell Signaling in human mouse rat
              VEGF Signaling in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFATC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFATC4 (Q149341, 2, 3 ENSP000003889104) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG481, 2, 3, ENSP000003448184EBI-3905796,EBI-3390054 MINT-6798334 MINT-6798349 MINT-6798321 I2D: score=1 STRING: ENSP00000344818
    YWHAQP273482, 3, ENSP000002380814MINT-8005440 MINT-8005433 I2D: score=3 STRING: ENSP00000238081
    PASKQ96RG22, 3, ENSP000002340404MINT-8145397 I2D: score=1 STRING: ENSP00000234040
    MAPK8P459833, ENSP000003534834I2D: score=1 STRING: ENSP00000353483
    CREBBPQ927933, ENSP000002623674I2D: score=3 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS7749981
    GO:0006954inflammatory response TAS7749981
    GO:0007507heart development IEA--

    Find genes that share ontologies with NFATC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NFATC4 (NFAC4)

    1 HMDB Compound for NFATC4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for NFATC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 17640476 (1)



    Find genes that share compounds with NFATC4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NFATC4 gene (6 alternative transcripts): 
    NM_001136022.2  NM_001198965.1  NM_001198966.2  NM_001198967.2  NM_001288802.1  NM_004554.4  

    Unigene Cluster for NFATC4:

    Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
    Hs.77810  [show with all ESTs]
    Unigene Representative Sequence: EU887634
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000440487 ENST00000413692(uc010alr.3 uc010tok.2 uc010tol.2)
    ENST00000554591 ENST00000556957 ENST00000555590 ENST00000554966 ENST00000424781(uc010too.2 uc010tom.2 uc010ton.2)
    ENST00000539237(uc010toq.2 uc010alt.3 uc010top.2) ENST00000556279
    ENST00000553469 ENST00000554050 ENST00000554655 ENST00000554903 ENST00000554779
    ENST00000557028(uc010alu.3) ENST00000250373(uc001wpc.3 uc010tor.2)
    ENST00000553708 ENST00000557674
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    Additional mRNA sequence: 

    AK293185.1 AK293873.1 AK300450.1 AK302271.1 AK309339.1 AK309907.1 AK310433.1 AK310445.1 
    AK311078.1 AK311425.1 BC008857.2 BC053855.1 EU887632.1 EU887633.1 EU887634.1 EU887635.1 
    EU887636.1 EU887637.1 EU887638.1 EU887639.1 EU887640.1 EU887641.1 EU887642.1 EU887643.1 
    EU887644.1 EU887645.1 EU887646.1 EU887647.1 EU887648.1 EU887649.1 EU887650.1 EU887651.1 
    EU887652.1 EU887653.1 EU887654.1 EU887655.1 L41066.1 

    14 DOTS entries:

    DT.91728470  DT.75134113  DT.95370134  DT.91703045  DT.95231325  DT.100819135  DT.100717837  DT.100819132 
    DT.120754161  DT.100843231  DT.120754213  DT.120754214  DT.100728985  DT.40116538 

    Selected AceView cDNA sequences (see all 220):

    BX282161 BX489469 AA293310 BQ889427 BM710454 NM_004554 BU736075 BE464659 
    CR607958 BM797235 CA432165 BX104376 CA418944 AW960210 CR607836 CA976004 
    AA377473 BF725867 BG059648 BF726084 AI806528 BC053855 BP356659 BM550568 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFATC4 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                      -                 -           -                                                         
    SP2:                    -                 -                 -           -                                                         
    SP3:                                                        -           -                                                         
    SP4:                                                                    -                                                         
    SP5:                                                                                                              -               


    ECgene alternative splicing isoforms for NFATC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NFATC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAAAAGT
    NFATC4 Expression
    About this image


    NFATC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocytes Myocardium
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Ovary (Reproductive System)
     
     Uterus (Reproductive System)
    NFATC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFATC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77810

    UniProtKB/Swiss-Prot: NFAC4_HUMAN, Q14934
    Tissue specificity: Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and
    thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFATC4: 
              Stem Cell Signaling in human mouse rat
              VEGF Signaling in human mouse rat
              Transcription Factors in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for NFATC4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfatc41 , 5 nuclear factor of activated T cells, cytoplasmic, calcineurin more1, 5 87.47(n)1
    91.81(a)1
      14 (28.19 cM)5
    731811  NM_023699.31  NP_076188.31 
     558247955 
    lizard
    (Anolis carolinensis)
    Reptilia NFATC46
    nuclear factor of activated T-cells, cytoplasmic, ...
    65(a)
    1 ↔ 1
    GL343220.1(653220-697542)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nfatc41 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent more 58.9(n)
    63.35(a)
      100489466  XM_002934323.2  XP_002934369.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570801662   -- 72.12(n)    57080166 
    fruit fly
    (Drosophila melanogaster)
    Insecta NFAT6
    NFAT homolog
    10(a)
    1 → many
    X(13518778-13558601)


    ENSEMBL Gene Tree for NFATC4 (if available)
    TreeFam Gene Tree for NFATC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFATC4 gene
    NFATC32  NFAT52  NFATC12  NFATC22  
    1 SIMAP similar gene for NFATC4 using alignment to 5 protein entries:     NFAC4_HUMAN (see all proteins):
    NFATC3

    Find genes that share paralogs with NFATC4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFATC4 (see all 385)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008287141,2
    C--4951057(+) GTGTGG/TGGGAG 1 -- us2k10--------
    rs1876091151,2
    --24834189(+) ATTTAC/TTTTTA 2 -- us2k10--------
    rs786897751,2
    C,F--24834201(+) TAGAGG/ACAAGG 2 -- us2k12Minor allele frequency- A:0.33WA CSA 3
    rs1448089891,2
    --24834239(+) CTGTGA/GCTATA 2 -- us2k10--------
    rs128889651,2
    C,F--24834291(+) GTGACC/TTGTTC 2 -- us2k18Minor allele frequency- T:0.27NA WA EA 368
    rs1902936351,2
    --24834346(+) TTTTCC/TATTCT 2 -- us2k10--------
    rs1179545541,2
    C,F--24834384(+) TCACTA/GTAAAC 2 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1821685671,2
    --24834394(+) CTACCC/TACATC 2 -- us2k10--------
    rs1485337981,2
    C--24834408(+) TTCTTA/GTCTCA 2 -- us2k10--------
    rs1160756971,2
    F--24834532(+) TTGCTA/GACCTG 2 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for NFATC4 (24834879 - 24848810 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NFATC4: --
    Human Gene Mutation Database (HGMD): NFATC4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFATC4
    DNA2.0 Custom Variant and Variant Library Synthesis for NFATC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602699    OMIM disorders: --


    Find genes that share disorders with NFATC4           About GenesLikeMe

    3 Novoseek inferred disease relationships for NFATC4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 70.8 2 12939651 (1), 9568714 (1)
    dilated cardiomyopathy 44.9 2 15012912 (1), 12939651 (1)
    heart failure 16.4 2 15012912 (1), 9568714 (1)

    Genetic Association Database (GAD): NFATC4
    Human Genome Epidemiology (HuGE) Navigator: NFATC4 (9 documents)

    Export disorders for NFATC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFATC4 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with NFATC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. (PubMed id 7749981)1, 2, 3 Hoey T.... Xu X. (Immunity 1995)
    2. Alternative splicing and expression of human and mouse NFAT genes. (PubMed id 18675896)1, 2, 9 Vihma H.... Timmusk T. (Genomics 2008)
    3. Polymorphisms of genes of the cardiac calcineurin pathway and cardiac hypertrophy. (PubMed id 12939651)1, 4, 9 Poirier O....Cambien F. (Eur. J. Hum. Genet. 2003)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. (PubMed id 19653005)1, 4 Ahmetov I.I....Rogozkin V.A. (Hum. Genet. 2009)
    6. Repression of NFAT3 transcriptional activity by estrogen receptors. (PubMed id 18668201)1, 2 Qin X.... Ye Q.-N. (Cell. Mol. Life Sci. 2008)
    7. Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination. (PubMed id 19026640)1, 2 Fan Y.... Li H. (FEBS Lett. 2008)
    8. Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2- AP-1 induced cell transformation. (PubMed id 17875713)1, 2 Yao K.... Dong Z. (Cancer Res. 2007)
    9. RSK2 mediates muscle cell differentiation through regulation of NFAT3. (PubMed id 17213202)1, 2 Cho Y.-Y.... Dong Z. (J. Biol. Chem. 2007)
    10. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. (PubMed id 11997522)1, 2 Yang T.T.C.... Chow C.-W. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4776 HGNC: 7778 AceView: NFATC4 Ensembl:ENSG00000100968 euGenes: HUgn4776
    ECgene: NFATC4 Kegg: 4776 H-InvDB: NFATC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NFATC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFATC4 gene:
    Search GeneIP for patents involving NFATC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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