Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NFATC3 Gene

Aliases for NFATC3 Gene

  • Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3 2 3
  • NF-ATc3 3 4
  • NFATX 3 4
  • NFAT4 3 4
  • Nuclear Factor Of Activated T-Cells C3 Isoform IE-Xa 3
  • T Cell Transcription Factor NFAT4 3
  • T-Cell Transcription Factor NFAT4 4
  • NF-AT4 4
  • NFATc3 4

External Ids for NFATC3 Gene

Previous GeneCards Identifiers for NFATC3 Gene

  • GC16P058814
  • GC16P068497
  • GC16P067854
  • GC16P067895
  • GC16P066676
  • GC16P053992

Summaries for NFATC3 Gene

Entrez Gene Summary for NFATC3 Gene

  • The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for NFATC3 Gene

NFATC3 (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NFATC4.

UniProtKB/Swiss-Prot for NFATC3 Gene

  • Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Gene Wiki entry for NFATC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFATC3 Gene

Genomics for NFATC3 Gene

Regulatory Elements for NFATC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFATC3 Gene

Chromosome:
16
Start:
68,084,751 bp from pter
End:
68,229,259 bp from pter
Size:
144,509 bases
Orientation:
Plus strand

Genomic View for NFATC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFATC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFATC3 Gene

Proteins for NFATC3 Gene

  • Protein details for NFATC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12968-NFAC3_HUMAN
    Recommended name:
    Nuclear factor of activated T-cells, cytoplasmic 3
    Protein Accession:
    Q12968
    Secondary Accessions:
    • O75211
    • Q14516
    • Q99840
    • Q99841
    • Q99842

    Protein attributes for NFATC3 Gene

    Size:
    1075 amino acids
    Molecular mass:
    115594 Da
    Quaternary structure:
    • Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers

    Three dimensional structures from OCA and Proteopedia for NFATC3 Gene

    Alternative splice isoforms for NFATC3 Gene

neXtProt entry for NFATC3 Gene

Proteomics data for NFATC3 Gene at MOPED

Post-translational modifications for NFATC3 Gene

  • Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NFATC3 Gene

Domains & Families for NFATC3 Gene

Gene Families for NFATC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q12968

UniProtKB/Swiss-Prot:

NFAC3_HUMAN :
  • Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors
Domain:
  • Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors
  • Contains 1 RHD (Rel-like) domain.
genes like me logo Genes that share domains with NFATC3: view

Function for NFATC3 Gene

Molecular function for NFATC3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Gene Ontology (GO) - Molecular Function for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 15173172
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 15173172
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with NFATC3: view
genes like me logo Genes that share phenotypes with NFATC3: view

Animal Models for NFATC3 Gene

MGI Knock Outs for NFATC3:

Animal Model Products

Transcription Factor Targets for NFATC3 Gene

Selected GeneGlobe predicted Target genes for NFATC3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFATC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for NFATC3 Gene

Localization for NFATC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFATC3 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFATC3 Gene COMPARTMENTS Subcellular localization image for NFATC3 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12370307
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 18815128
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NFATC3: view

Pathways & Interactions for NFATC3 Gene

genes like me logo Genes that share pathways with NFATC3: view

PCR Array Products

SIGNOR curated interactions for NFATC3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 patterning of blood vessels IEA --
GO:0001666 response to hypoxia IEA --
GO:0001974 blood vessel remodeling IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with NFATC3: view

Drugs & Compounds for NFATC3 Gene

(3) Drugs for NFATC3 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tacrolimus Approved, Investigational Pharma 992
Calcium Nutra 0
Cyclosporin A Pharma Inhibition, Inhibitor Immunosuppressive agent, Calcineurin inhibitor 0

(1) Additional Compounds for NFATC3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IONOMYCIN
genes like me logo Genes that share compounds with NFATC3: view

Transcripts for NFATC3 Gene

Unigene Clusters for NFATC3 Gene

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFATC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFATC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for NFATC3 Gene

GeneLoc Exon Structure for
NFATC3
ECgene alternative splicing isoforms for
NFATC3

Expression for NFATC3 Gene

mRNA expression in normal human tissues for NFATC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFATC3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for NFATC3 Gene

This gene is overexpressed in Breast (39.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFATC3 Gene



SOURCE GeneReport for Unigene cluster for NFATC3 Gene Hs.436585

mRNA Expression by UniProt/SwissProt for NFATC3 Gene

Q12968-NFAC3_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle
genes like me logo Genes that share expression patterns with NFATC3: view

Protein tissue co-expression partners for NFATC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NFATC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFATC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NFATC3 35
  • 93.2 (n)
  • 93.76 (a)
NFATC3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFATC3 35
  • 93.27 (n)
  • 93.49 (a)
NFATC3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfatc3 35
  • 89.79 (n)
  • 89.61 (a)
Nfatc3 16
Nfatc3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NFATC3 35
  • 99.6 (n)
  • 99.44 (a)
NFATC3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfatc3 35
  • 90.1 (n)
  • 90.33 (a)
oppossum
(Monodelphis domestica)
Mammalia NFATC3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFATC3 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFATC3 35
  • 77.04 (n)
  • 77.08 (a)
NFATC3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFATC3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfatc3 35
  • 65.34 (n)
  • 64.58 (a)
Str.18348 35
African clawed frog
(Xenopus laevis)
Amphibia nf-at 35
zebrafish
(Danio rerio)
Actinopterygii nfatc3 35
  • 62.48 (n)
  • 64.57 (a)
NFATC3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NFAT 36
  • 12 (a)
OneToMany
Species with no ortholog for NFATC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFATC3 Gene

ENSEMBL:
Gene Tree for NFATC3 (if available)
TreeFam:
Gene Tree for NFATC3 (if available)

Paralogs for NFATC3 Gene

Paralogs for NFATC3 Gene

genes like me logo Genes that share paralogs with NFATC3: view

Variants for NFATC3 Gene

Sequence variations from dbSNP and Humsavar for NFATC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11871 -- 68,227,531(+) GATGG(A/G)AAGGT utr-variant-3-prime
rs12598 -- 68,191,612(+) AGTAC(A/G)GGCCA synonymous-codon, reference
rs237833 -- 68,098,300(-) aaaaa(A/T)aataa intron-variant
rs237834 -- 68,091,413(-) CAAAC(C/T)TCAAA intron-variant
rs237835 -- 68,083,921(-) TATTG(C/G)TTCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NFATC3 Gene

Variant ID Type Subtype PubMed ID
nsv906817 CNV Loss 21882294
nsv1846 CNV Insertion 18451855

Variation tolerance for NFATC3 Gene

Residual Variation Intolerance Score: 17.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFATC3 Gene

HapMap Linkage Disequilibrium report
NFATC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFATC3 Gene

Disorders for NFATC3 Gene

Relevant External Links for NFATC3

Genetic Association Database (GAD)
NFATC3
Human Genome Epidemiology (HuGE) Navigator
NFATC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFATC3
genes like me logo Genes that share disorders with NFATC3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFATC3 Gene

Publications for NFATC3 Gene

  1. Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. (PMID: 20369390) Butterick T.A. … Wood W.G. (Mol. Neurobiol. 2010) 23 67
  2. The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. (PMID: 19883655) Li J. … Kapiloff M.S. (J. Mol. Cell. Cardiol. 2010) 23 67
  3. Control of mitochondrial biogenesis, ROS level, and cytosolic Ca2+ concentration during the cell cycle and the onset of differentiation in L6E9 myoblasts. (PMID: 19295176) Jahnke V.E. … Freyssenet D. (Am. J. Physiol., Cell Physiol. 2009) 23 67
  4. Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. (PMID: 19540841) Rinne A. … Blatter L.A. (J. Mol. Cell. Cardiol. 2009) 23 67
  5. A novel function of CXCL13 to stimulate RANK ligand expression in oral squamous cell carcinoma cells. (PMID: 19671684) Yuvaraj S. … Reddy S.V. (Mol. Cancer Res. 2009) 23 67

Products for NFATC3 Gene

Sources for NFATC3 Gene

Back to Top

Content