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Aliases for NFATC3 Gene

Aliases for NFATC3 Gene

  • Nuclear Factor Of Activated T-Cells 3 2 3 5
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3 2 3
  • NF-ATc3 3 4
  • NFATX 3 4
  • NFAT4 3 4
  • Nuclear Factor Of Activated T-Cells C3 Isoform IE-Xa 3
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic 3 3
  • T Cell Transcription Factor NFAT4 3
  • T-Cell Transcription Factor NFAT4 4
  • NF-AT4 4
  • NFATc3 4

External Ids for NFATC3 Gene

Previous GeneCards Identifiers for NFATC3 Gene

  • GC16P058814
  • GC16P068497
  • GC16P067854
  • GC16P067895
  • GC16P066676
  • GC16P053992

Summaries for NFATC3 Gene

Entrez Gene Summary for NFATC3 Gene

  • The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for NFATC3 Gene

NFATC3 (Nuclear Factor Of Activated T-Cells 3) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and RANK Signaling in Osteoclasts. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NFATC4.

UniProtKB/Swiss-Prot for NFATC3 Gene

  • Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Tocris Summary for NFATC3 Gene

  • NFAT (Nuclear Factor of Activated T-Cells) proteins are transcription factors that are integral for the development and function of the immune system. Five NFAT isoforms have been identified to date, NFATC1-C4 and NFAT5.

Gene Wiki entry for NFATC3 Gene

Additional gene information for NFATC3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFATC3 Gene

Genomics for NFATC3 Gene

Regulatory Elements for NFATC3 Gene

Enhancers for NFATC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H068279 2 FANTOM5 Ensembl ENCODE dbSUPER 20.1 +201.7 201710 13 HDGF PKNOX1 FOXA2 MLX SIN3A ARID4B DMAP1 SLC30A9 ZNF766 FOS PRMT7 SLC7A6 NFATC3 SLC7A6OS RNU4-30P DUS2 RANBP10 DPEP2 PSMB10 LRRC36
GH16H068004 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.3 -78.9 -78856 2 SAP130 MAX CEBPG ZNF766 GATA3 ZNF639 SMARCE1 L3MBTL2 CEBPB KLF4 DPEP2 NFATC3 DPEP3 PSMB10 PRMT7 ACD PARD6A LCAT DDX28 RANBP10
GH16H067934 1.4 ENCODE dbSUPER 23 -148.5 -148485 4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 NFATC3 EDC4 DPEP3 THAP11 NRN1L PSKH1 DUS2 LCAT SLC12A4 E2F4
GH16H067182 1.1 ENCODE 21.7 -899.3 -899335 5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 EDC4 E2F4 NFATC3 CTCF ACD ENSG00000260465 CENPT ELMO3 ENSG00000270165 NAE1
GH16H067854 1.7 FANTOM5 Ensembl ENCODE 12.7 -227.6 -227576 4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TCF12 ZNF121 ZNF143 RANBP10 ACD NFATC3 NRN1L TSNAXIP1 DUS2 PSKH1 E2F4 SLC12A4 PARD6A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NFATC3 on UCSC Golden Path with GeneCards custom track

Promoters for NFATC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087232 1449 3201 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for NFATC3 Gene

Chromosome:
16
Start:
68,084,751 bp from pter
End:
68,229,259 bp from pter
Size:
144,509 bases
Orientation:
Plus strand

Genomic View for NFATC3 Gene

Genes around NFATC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFATC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFATC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFATC3 Gene

Proteins for NFATC3 Gene

  • Protein details for NFATC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12968-NFAC3_HUMAN
    Recommended name:
    Nuclear factor of activated T-cells, cytoplasmic 3
    Protein Accession:
    Q12968
    Secondary Accessions:
    • O75211
    • Q14516
    • Q99840
    • Q99841
    • Q99842

    Protein attributes for NFATC3 Gene

    Size:
    1075 amino acids
    Molecular mass:
    115594 Da
    Quaternary structure:
    • Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers.

    Three dimensional structures from OCA and Proteopedia for NFATC3 Gene

    Alternative splice isoforms for NFATC3 Gene

neXtProt entry for NFATC3 Gene

Post-translational modifications for NFATC3 Gene

  • Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NFATC3 (NFAT4)
  • Abcam antibodies for NFATC3

No data available for DME Specific Peptides for NFATC3 Gene

Domains & Families for NFATC3 Gene

Gene Families for NFATC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

Q12968

UniProtKB/Swiss-Prot:

NFAC3_HUMAN :
  • Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
Domain:
  • Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
genes like me logo Genes that share domains with NFATC3: view

Function for NFATC3 Gene

Molecular function for NFATC3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Phenotypes From GWAS Catalog for NFATC3 Gene

Gene Ontology (GO) - Molecular Function for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 15173172
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 15173172
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IGI 23543060
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NFATC3: view
genes like me logo Genes that share phenotypes with NFATC3: view

Animal Models for NFATC3 Gene

MGI Knock Outs for NFATC3:

Animal Model Products

CRISPR Products

Transcription Factor Targets for NFATC3 Gene

Selected GeneGlobe predicted Target genes for NFATC3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFATC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for NFATC3 Gene

Localization for NFATC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFATC3 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFATC3 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12370307
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IEA,IDA 18815128
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with NFATC3: view

Pathways & Interactions for NFATC3 Gene

genes like me logo Genes that share pathways with NFATC3: view

SIGNOR curated interactions for NFATC3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NFATC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7749981
GO:0006366 transcription from RNA polymerase II promoter TAS 7739550
GO:0006954 inflammatory response TAS 7739550
genes like me logo Genes that share ontologies with NFATC3: view

Drugs & Compounds for NFATC3 Gene

(5) Drugs for NFATC3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
NFAT Inhibitor Pharma NFAT inhibitor, Inhibitor of calcineurin-mediated NFAT activation 0

(1) Additional Compounds for NFATC3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NFAT inhibitor, Cell Permeable
592517-80-1

(2) Tocris Compounds for NFATC3 Gene

Compound Action Cas Number
NFAT Inhibitor Inhibitor of calcineurin-mediated NFAT activation 249537-73-3
NFAT inhibitor, Cell Permeable Cell permeable NFAT inhibitor 592517-80-1
genes like me logo Genes that share compounds with NFATC3: view

Transcripts for NFATC3 Gene

Unigene Clusters for NFATC3 Gene

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NFATC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NFATC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for NFATC3 Gene

GeneLoc Exon Structure for
NFATC3
ECgene alternative splicing isoforms for
NFATC3

Expression for NFATC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFATC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NFATC3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for NFATC3 Gene

This gene is overexpressed in Breast (39.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFATC3 Gene



Protein tissue co-expression partners for NFATC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFATC3 Gene:

NFATC3

SOURCE GeneReport for Unigene cluster for NFATC3 Gene:

Hs.436585

mRNA Expression by UniProt/SwissProt for NFATC3 Gene:

Q12968-NFAC3_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.

Evidence on tissue expression from TISSUES for NFATC3 Gene

  • Muscle(4.6)
  • Blood(4.5)
  • Kidney(4.4)
  • Lung(3.2)
  • Nervous system(3.1)
  • Heart(2.6)
genes like me logo Genes that share expression patterns with NFATC3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NFATC3 Gene

Orthologs for NFATC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFATC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFATC3 34 33
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NFATC3 33 34
  • 93.27 (n)
cow
(Bos Taurus)
Mammalia NFATC3 33 34
  • 93.2 (n)
rat
(Rattus norvegicus)
Mammalia Nfatc3 33
  • 90.1 (n)
mouse
(Mus musculus)
Mammalia Nfatc3 33 16 34
  • 89.79 (n)
oppossum
(Monodelphis domestica)
Mammalia NFATC3 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFATC3 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NFATC3 34 33
  • 77.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFATC3 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nfatc3 33
  • 65.34 (n)
Str.18348 33
African clawed frog
(Xenopus laevis)
Amphibia nf-at 33
zebrafish
(Danio rerio)
Actinopterygii nfatc3 33
  • 62.48 (n)
NFATC3 34
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NFAT 34
  • 12 (a)
OneToMany
Species where no ortholog for NFATC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFATC3 Gene

ENSEMBL:
Gene Tree for NFATC3 (if available)
TreeFam:
Gene Tree for NFATC3 (if available)

Paralogs for NFATC3 Gene

Paralogs for NFATC3 Gene

genes like me logo Genes that share paralogs with NFATC3: view

Variants for NFATC3 Gene

Sequence variations from dbSNP and Humsavar for NFATC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000003648 -- 68,164,173(+) GGCTG(A/G)CGGAT intron-variant
rs1000019222 -- 68,115,583(+) CCATG(C/G)CCAGC intron-variant
rs1000023194 -- 68,211,371(+) TTAGT(A/G)GAGAC intron-variant
rs1000048003 -- 68,205,259(+) GGTGG(A/C/G)GGAAC intron-variant
rs1000053718 -- 68,162,578(+) ATTTC(A/C)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFATC3 Gene

Variant ID Type Subtype PubMed ID
dgv2996n100 CNV loss 25217958
esv3638903 CNV loss 21293372
nsv1126432 CNV deletion 24896259
nsv1148964 CNV insertion 26484159
nsv1846 CNV insertion 18451855
nsv977989 CNV duplication 23825009

Variation tolerance for NFATC3 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFATC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFATC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFATC3 Gene

Disorders for NFATC3 Gene

Relevant External Links for NFATC3

Genetic Association Database (GAD)
NFATC3
Human Genome Epidemiology (HuGE) Navigator
NFATC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFATC3

No disorders were found for NFATC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFATC3 Gene

Publications for NFATC3 Gene

  1. Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells. (PMID: 9759864) Imamura R … Arai N (Journal of immunology (Baltimore, Md. : 1950) 1998) 3 4 22 60
  2. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. (PMID: 9630228) Zhu J … McKeon F (Cell 1998) 3 4 22 60
  3. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. (PMID: 7739550) Masuda ES … Arai N (Molecular and cellular biology 1995) 3 4 22 60
  4. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. (PMID: 7749981) Hoey T … Xu X (Immunity 1995) 2 3 4 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for NFATC3 Gene

Sources for NFATC3 Gene

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