Aliases for NFATC3 Gene
External Ids for NFATC3 Gene
Previous GeneCards Identifiers for NFATC3 Gene
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for NFATC3 Gene
NFATC3 (Nuclear Factor Of Activated T-Cells 3) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and RANK Signaling in Osteoclasts. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NFATC4.
UniProtKB/Swiss-Prot for NFATC3 Gene
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
NFAT (Nuclear Factor of Activated T-Cells) proteins are transcription factors that are integral for the development and function of the immune system. Five NFAT isoforms have been identified to date, NFATC1-C4 and NFAT5.