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NFATC3 Gene

protein-coding   GIFtS: 63
GCID: GC16P068119

Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent
31 2
     T Cell Transcription Factor NFAT42
NF-ATc32 3     NF-AT43
NFAT42 3     NFATc33
NFATX2     NFATx3
Nuclear Factor Of Activated T-Cells C3 Isoform IE-Xa2     T-Cell Transcription Factor NFAT43
Nuclear Factor Of Activated T-Cells, Cytoplasmic 32     

External Ids:    HGNC: 77771   Entrez Gene: 47752   Ensembl: ENSG000000727367   OMIM: 6026985   UniProtKB: Q129683   

Export aliases for NFATC3 gene to outside databases

Previous GC identifers: GC16P058814 GC16P068497 GC16P067854 GC16P067895 GC16P066676 GC16P053992


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFATC3 Gene:
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription
complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to
the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this
family participate to form this complex also. The product of this gene plays a role in the regulation of gene
expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for NFATC3 Gene:
NFATC3 (nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3) is a protein-coding gene. Diseases associated with NFATC3 include north american indian childhood cirrhosis, and oral squamous cell carcinoma. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFATC4.

UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968
Function: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine
genes in T-cells, especially in the induction of the IL-2

Gene Wiki entry for NFATC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFATC3 gene promoter:
         AREB6   GR   RORalpha1   ATF-2   Hand1   GR-alpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFATC3 promoter sequence
   Search Chromatin IP Primers for NFATC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFATC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

NFATC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFATC3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P068119:  view genomic region     (about GC identifiers)

Start:
68,118,654 bp from pter      End:
68,263,162 bp from pter
Size:
144,509 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968 (See protein sequence)
Recommended Name: Nuclear factor of activated T-cells, cytoplasmic 3  
Size: 1075 amino acids; 115594 Da
Subunit: Member of the multicomponent NFATC transcription complex that consists of at least two components, a
pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as
NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex.
NFATC proteins bind to DNA as monomers
2 PDB 3D structures from and Proteopedia for NFATC3:
2XRW (3D)        2XS0 (3D)    
Secondary accessions: O75211 Q14516 Q99840 Q99841 Q99842
Alternative splicing: 6 isoforms:  Q12968-1   Q12968-2   Q12968-3   Q12968-4   Q12968-5   Q12968-6   

Explore the universe of human proteins at neXtProt for NFATC3: NX_Q12968

Explore proteomics data for NFATC3 at MOPED

Post-translational modifications: 

  • Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NFATC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004546.1  NP_775186.1  NP_775188.1  

    ENSEMBL proteins: 
     ENSP00000460533   ENSP00000455113   ENSP00000454451   ENSP00000445670   ENSP00000456307  
     ENSP00000264008   ENSP00000300659   ENSP00000331324   ENSP00000456379   ENSP00000456120  
     ENSP00000457441  
    Reactome Protein details: Q12968

    NFATC3 Human Recombinant Protein Products:

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    Novus Biologicals NFATC3 Proteins
    Novus Biologicals NFATC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NFATC3

    NFATC3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NFATC3
    Cell Signaling Technology (CST) Antibodies for NFATC3  (NFAT4)
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    OriGene Custom Antibody Services for NFATC3
    Novus Biologicals NFATC3 Antibodies
    Abcam antibodies for NFATC3
    Cloud-Clone Corp. Antibodies for NFATC3
    Search ThermoFisher Antibodies for NFATC3
    LSBio Antibodies in human, mouse, rat for NFATC3

    NFATC3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NFATC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NFATC3
    Cloud-Clone Corp. CLIAs for NFATC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NFAT: Nuclear factor of activated T-cells

    Selected InterPro protein domains (see all 6):
     IPR014756 Ig_E-set
     IPR008967 p53-like_TF_DNA-bd
     IPR002909 IPT
     IPR013783 Ig-like_fold
     IPR011539 RHD

    Graphical View of Domain Structure for InterPro Entry Q12968

    ProtoNet protein and cluster: Q12968

    3 Blocks protein domains:
    IPB002909 Cell surface receptor IPT/TIG
    IPB008366 Nuclear factor of activated T cells (NFAT) signature
    IPB011539 Rel homology


    UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968
    Domain: Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors
    Similarity: Contains 1 RHD (Rel-like) domain


    NFATC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFAC3_HUMAN, Q12968
    Function: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine
    genes in T-cells, especially in the induction of the IL-2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
         
    NFATC3 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nfatc3) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  nervous system  normal  reproductive system 

    NFATC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NFATC3: Nfatc3tm1Glm Nfatc3tm1.1Grc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFATC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NFATC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NFATC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NFATC3

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NFATC3 (see all 311):
    ACBD7,  ACER1,  ACOT12,  ACVR2A,  ADAL,  ALDH1B1,  ANKRD22,  ANKRD30B,  ANKRD34C,  ANO3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NFATC3:
    hsa-mir-9-5p (MIRT021368), hsa-let-7b-5p (MIRT052288), hsa-mir-324-3p (MIRT042979), hsa-mir-361-3p (MIRT038275)

    Block miRNA regulation of human, mouse, rat NFATC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NFATC3 (see all 96):
    hsa-miR-579 hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-376b hsa-miR-15a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidNFATC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NFATC3
    Predesigned siRNA for gene silencing in human, mouse, rat NFATC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NFATC3

    Clone
    Products:
         
    OriGene clones in human, mouse for NFATC3 (see all 20)
    OriGene ORF clones in mouse, rat for NFATC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NFATC3 (NM_173163)
    Sino Biological Human cDNA Clone for NFATC3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFATC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFATC3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NFATC3
    Browse ESI BIO Cell Lines and PureStem Progenitors for NFATC3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFATC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFAC3_HUMAN, Q12968: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after
    activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought
    to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular
    localization of NFATC plays a key role in the regulation of gene transcription
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    NFATC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NFATC3 About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1fMLP Pathway
    fMLP Pathway0.43
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    4TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    ITK and TCR Signaling0.54
    TCR Signaling0.68
    Fc-EpsilonRI Pathway0.49
    5RANK Signaling in Osteoclasts
    APRIL Pathway0.92
    RANK Signaling in Osteoclasts0.45
    BAFF in B-Cell Signaling0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for NFATC3
        Wnt Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NFATC3 (see all 29)
        PKA Signaling
    Intracellular Calcium Signaling
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway
    PI3K Signaling in B-Lymphocyte

    1 Cell Signaling Technology (CST) Pathway for NFATC3
        Lymphocyte Signaling

    5 GeneGo (Thomson Reuters) Pathways for NFATC3
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Signal transduction JNK pathway
    Immune response T cell receptor signaling pathway
    Immune response CD28 signaling
    Immune response NFAT in immune response

    Selected BioSystems Pathways for NFATC3 (see all 8)
        Heart Development
    B Cell Receptor Signaling Pathway
    Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    FOXM1 transcription factor network

    1 Sino Biological Pathway for NFATC3
        Non-Canonical Wnt Pathway

    1 Reactome Pathway for NFATC3
        FCERI mediated Ca+2 mobilization


    Selected Kegg Pathways  (Kegg details for NFATC3) (see all 8):
        MAPK signaling pathway
    Wnt signaling pathway
    Axon guidance
    T cell receptor signaling pathway
    B cell receptor signaling pathway


    NFATC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFATC3 (see all 6): 
              Stem Cell Signaling in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Transcription Factors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NFATC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NFATC3 (Q129683 ENSP000003006594) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK9P459843, ENSP000003214104I2D: score=2 STRING: ENSP00000321410
    TTF1Q153613, ENSP000003339204I2D: score=1 STRING: ENSP00000333920
    CSNK1A1P487293, ENSP000002617984I2D: score=2 STRING: ENSP00000261798
    FOSP011003, ENSP000003062454I2D: score=2 STRING: ENSP00000306245
    NCOA3Q9Y6Q93, ENSP000003610664I2D: score=1 STRING: ENSP00000361066
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS7749981
    GO:0006366transcription from RNA polymerase II promoter TAS7739550
    GO:0006954inflammatory response TAS7739550

    NFATC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFATC3 (NFAC3)

    1 HMDB Compound for NFATC3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for NFATC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 54.4 3 18463795 (1), 11278965 (1)
    cyclosporin a 43.6 3 19592461 (1), 9498773 (1), 10887328 (1)
    tacrolimus 43.3 2 18463795 (1), 11278965 (1)
    calcium 31.7 9 12954637 (3), 12671993 (1), 7739550 (1), 11278965 (1) (see all 5)



    NFATC3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NFATC3 gene (4 alternative transcripts): 
    NM_004555.3  NM_173163.2  NM_173165.2  NM_173164.1  

    Unigene Cluster for NFATC3:

    Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
    Hs.436585  [show with all ESTs]
    Unigene Representative Sequence: NM_004555
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000553077(uc010vkl.2) ENST00000569766 ENST00000563319 ENST00000549350(uc010vko.2)
    ENST00000566301 ENST00000566893 ENST00000575270 ENST00000561714 ENST00000568466
    ENST00000539828(uc002evl.3) ENST00000562171 ENST00000349223(uc002evm.2 uc002evn.2 uc002evo.2)
    ENST00000379165(uc002evk.3 uc010vkr.2 uc010vku.2 uc010vkx.2)
    ENST00000346183(uc010vkm.2 uc010vkq.2 uc010vks.2 uc010vkv.2 uc010vky.2 uc010vlb.2)
    ENST00000329524(uc010vkn.2 uc010vkp.2 uc010vkt.2 uc010vkw.2 uc010vkz.2 uc010vlc.2)
    ENST00000570212 ENST00000562926 ENST00000567152

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NFATC3 (see all 96):
    hsa-miR-579 hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-376b hsa-miR-15a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidNFATC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NFATC3
    Predesigned siRNA for gene silencing in human, mouse, rat NFATC3
    Clone
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    OriGene clones in human, mouse for NFATC3 (see all 20)
    OriGene ORF clones in mouse, rat for NFATC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NFATC3 (NM_173163)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NFATC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFATC3
    Primer
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    OriGene qPCR primer pairs and template standards for NFATC3
    OriGene qSTAR qPCR primer pairs in human, mouse for NFATC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NFATC3
      QuantiTect SYBR Green Assays in human, mouse, rat NFATC3
      QuantiFast Probe-based Assays in human, mouse, rat NFATC3

    Additional mRNA sequence: 

    AK290370.1 BC001050.2 EU887605.1 EU887606.1 EU887608.1 EU887609.1 EU887611.1 EU887612.1 
    EU887614.1 EU887615.1 EU887617.1 EU887618.1 EU887620.1 EU887621.1 EU887623.1 EU887624.1 
    L41067.1 U14510.1 U85428.1 U85429.1 

    Selected DOTS entries (see all 30):

    DT.80100987  DT.92415710  DT.99986182  DT.92435502  DT.100037863  DT.120665159  DT.97847233  DT.95193785 
    DT.120665072  DT.100818860  DT.92458544  DT.120664961  DT.120665170  DT.40131967  DT.92458546  DT.95148454 
    DT.95148459  DT.120664996  DT.427060  DT.91647134  DT.92458562  DT.100037864  DT.120665076  DT.217172 

    Selected AceView cDNA sequences (see all 471):

    BE391992 NM_173164 BQ949102 BM479989 AI051632 AI193390 BQ054685 AL515755 
    CF137974 AI961677 U14510 BM672189 L41067 AA661615 BU731230 BU527356 
    AA613587 NM_173163 BE407644 BU739910 AW294267 AA131942 AI276927 BC001050 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NFATC3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:              -     -     -                                                                             -         
    SP2:              -     -     -                                                                       -               
    SP3:              -     -     -                                                                       -     -         
    SP4:              -     -     -     -     -     -     -     -                                                         
    SP5:                    -     -                                                                                       


    ECgene alternative splicing isoforms for NFATC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NFATC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTCTCCT
    NFATC3 Expression
    About this image


    NFATC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Heart (Cardiovascular System)
             Cardiomyocytes Myocardium
    NFATC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFATC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436585

    UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968
    Tissue specificity: Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood
    leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus,
    kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in
    thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NFATC3 (see all 6): 
              Stem Cell Signaling in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Transcription Factors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for NFATC3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfatc31 , 5 nuclear factor of activated T cells, cytoplasmic, calcineurin more1, 5 89.79(n)1
    89.61(a)1
      8 (53.08 cM)5
    180211  NM_010901.21  NP_035031.21 
     1060596035 
    chicken
    (Gallus gallus)
    Aves NFATC31 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent more 77.04(n)
    77.08(a)
      415711  XM_414078.4  XP_414078.4 
    lizard
    (Anolis carolinensis)
    Reptilia NFATC36
    nuclear factor of activated T-cells, cytoplasmic, ...
    71(a)
    1 ↔ 1
    LGc(6294915-6334390)
    African clawed frog
    (Xenopus laevis)
    Amphibia nf-at2 nuclear factor of activated T-cell 74.75(n)    AB037471.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nfatc31 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent more 62.48(n)
    64.57(a)
      561772  XM_685181.6  XP_690273.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta NFAT6
    NFAT homolog
    12(a)
    1 → many
    X(13518778-13558601)


    ENSEMBL Gene Tree for NFATC3 (if available)
    TreeFam Gene Tree for NFATC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NFATC3 gene
    NFATC42  NFAT52  NFATC12  NFATC22  
    2 SIMAP similar genes for NFATC3 using alignment to 13 protein entries:     NFAC3_HUMAN (see all proteins):
    NFATC4    NFATC1

    NFATC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFATC3 (see all 2580)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606555991,2
    F--54005355(+) TTATTT/ATTTTT 3 -- int11Minor allele frequency- A:0.50NA 4
    rs2012234231,2
    --54099331(+) ATGTA-/TGTGTGT 3 -- int10--------
    rs713820341,2
    C--54099335(+) ATGTGTA/-TATAT 3 -- int11Minor allele frequency- -:0.50NA 2
    rs724432371,2
    C--54099336(+) TATAT-/AT/TA 
            
    GTATG
    3 -- int10--------
    rs1473381641,2
    C--54117360(+) TTCTC-/AAAAAA 3 -- int10--------
    rs1132247931,2
    C,F--54131476(+) ACAGGG/TTTTCA 3 -- int11Minor allele frequency- T:0.50WA 2
    rs113515561,2
    C--68124199(+) CGCAA-/C/CC  
            
    CCCCC
    3 -- int1 trp31NA 2
    rs611439131,2
    C--68124245(+) CACAC-/AC/CA 
            
    GAATA
    3 -- int10--------
    rs1124491201,2
    C,F--68134392(+) AAATCG/TCTTGA 3 -- int13Minor allele frequency- T:0.24CSA WA 121
    rs556771761,2
    C--68134792(+) GTGTG-/TGTG  
            
    GGGTG
    3 -- int10--------

    HapMap Linkage Disequilibrium report for NFATC3 (68118654 - 68263162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NFATC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1846CNV Insertion18451855
    nsv906817CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFATC3
    DNA2.0 Custom Variant and Variant Library Synthesis for NFATC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602698    OMIM disorders: --

    12 diseases for NFATC3:    
    About MalaCards
    north american indian childhood cirrhosis    oral squamous cell carcinoma    hepatitis b    hiv-1
    squamous cell carcinoma    hypertension    hypoxia    thyroiditis
    hepatitis    endotheliitis    prostatitis    neuronitis


    NFATC3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): NFATC3
    Human Genome Epidemiology (HuGE) Navigator: NFATC3 (6 documents)

    Export disorders for NFATC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFATC3 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with NFATC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. (PubMed id 7749981)1, 2, 3 Hoey T.... Xu X. (Immunity 1995)
    2. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. (PubMed id 9630228)1, 2, 9 Zhu J.... McKeon F. (Cell 1998)
    3. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. (PubMed id 7739550)1, 2, 9 Masuda E.S.... Arai N. (Mol. Cell. Biol. 1995)
    4. Carboxy-terminal 15 amino acids sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells. (PubMed id 9759864)1, 2, 9 Imamura R.... Arai N. (J. Immunol. 1998)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. (PubMed id 18815128)1, 2 Li G.D.... Zhang Y. (J. Biol. Chem. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    9. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. (PubMed id 10089876)1, 2 Crabtree G.R. (Cell 1999)
    10. Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets. (PubMed id 9498773)1, 9 Amasaki Y....Arai N. (J. Immunol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4775 HGNC: 7777 AceView: NFATC3 Ensembl:ENSG00000072736 euGenes: HUgn4775
    ECgene: NFATC3 Kegg: 4775 H-InvDB: NFATC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NFATC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFATC3 gene:
    Search GeneIP for patents involving NFATC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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