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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NFATC3 Gene

protein-coding GIFtS: 59
GCID: GC16P068119

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent...

Explore 12 diseases affiliated with
NFATC3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3¹ ²		T Cell Transcription Factor NFAT4²
NFAT4¹ ² ³		NF-AT4³
NFATX¹ ²		NFATc3³
NF-ATc3² ³		NFATx³
Nuclear Factor Of Activated T-Cells C3 Isoform IE-Xa²		T-Cell Transcription Factor NFAT4³
Nuclear Factor Of Activated T-Cells, Cytoplasmic 3²

External Ids:	HGNC: 7777¹	Entrez Gene: 4775²	Ensembl: ENSG00000072736⁷	OMIM: 602698⁵	UniProtKB: Q12968³

Export aliases for NFATC3 gene to outside databases

Previous GC identifers: GC16P058814 GC16P068497 GC16P067854 GC16P067895 GC16P066676 GC16P053992

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NFATC3:

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex.

This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus

upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to

form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and

immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene.

(provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968

Function: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes

in T-cells, especially in the induction of the IL-2

Gene Wiki entry for NFATC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NFATC3 gene promoter:
AREB6 GR RORalpha1 ATF-2 Hand1 GR-alpha E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NFATC3 promoter sequence

Search SABiosciences Chromatin IP Primers for NFATC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFATC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22

NFATC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFATC3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P068119: view genomic region (about GC identifiers)

Start:	68,118,654 bp from pter	End:	68,263,162 bp from pter
Size:	144,509 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968 (See protein sequence)

Recommended Name: Nuclear factor of activated T-cells, cytoplasmic 3

Size: 1075 amino acids; 115594 Da

Subunit: Member of the multicomponent NFATC transcription complex that consists of at least two components, a

pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4,

NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC

proteins bind to DNA as monomers

Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation

that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one

mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of

NFATC plays a key role in the regulation of gene transcription

2 PDB 3D structures from and Proteopedia for NFATC3:

2XRW (3D)

2XS0 (3D)

Secondary accessions: O75211 Q14516 Q99840 Q99841 Q99842

Alternative splicing: 6 isoforms: Q12968-1 Q12968-2 Q12968-3 Q12968-4 Q12968-5 Q12968-6

Explore the universe of human proteins at neXtProt for NFATC3: NX_Q12968

Post-translational modifications:

Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12968

NFATC3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_004546.1 NP_775186.1 NP_775188.1

ENSEMBL proteins:

ENSP00000460533 ENSP00000455113 ENSP00000454451 ENSP00000445670 ENSP00000456307

ENSP00000264008 ENSP00000300659 ENSP00000331324 ENSP00000456379 ENSP00000456120

ENSP00000457441

Reactome Protein details: Q12968
Human Recombinant Protein Products:

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	Novus Biologicals NFATC3 Proteins Novus Biologicals NFATC3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NFATC3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	18815128
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IDA	--

NFATC3 for ontologies About GeneDecksing

NFATC3 Antibody Products:

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	Search ThermoFisher Antibodies for NFATC3

Assay Products for NFATC3:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for NFATC3
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	Uscn ELISAs and CLIAs for NFATC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NFATC3 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR014756 Ig_E-set

IPR008967 p53-like_TF_DNA-bd

IPR002909 IPT_TIG_rcpt

IPR013783 Ig-like_fold

IPR011539 RHD

Graphical View of Domain Structure for InterPro Entry Q12968

ProtoNet protein and cluster: Q12968

3 Blocks protein families:

IPB002909 Cell surface receptor IPT/TIG

IPB008366 Nuclear factor of activated T cells (NFAT) signature

IPB011539 Rel homology

UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968

Domain: Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors

Similarity: Contains 1 RHD (Rel-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968

Function: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes

in T-cells, especially in the induction of the IL-2

		10/324 SABiosciences Target genes for NFATC3 (see all 324):
		ACBD7 ACER1 ACOT12 ACVR2A ADAL ALDH1B1 ANKRD22 ANKRD30B ANKRD34C ANO3

miRNA Products:		OriGene 3'-UTR Clone (see all 4): NFATC3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NFATC3
		8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate NFATC3 (see all 96):
		hsa-miR-579 hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-376b hsa-miR-15a hsa-miR-30d hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: NFATC3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFATC3 (see all 7) OriGene shRNA RFP: NFATC3 OriGene siRNA: NFATC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFATC3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NFATC3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC3 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NFATC3 (NM_173163)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFATC3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NFATC3
		Search LifeMap BioReagents cell lines for NFATC3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFATC3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	--	--

NFATC3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for NFATC3: Nfatc3^tm1Glm Nfatc3^tm1.1Grc
     15/17 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nfatc3) (see all 17):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	muscle	nervous system	normal	reproductive system

NFATC3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

PKC-Theta Pathway

	PKC-Theta Pathway	1.00			ITK and TCR Signaling	0.54
	TCR Signaling	0.68			Fc-EpsilonRI Pathway	0.42

BAFF in B-Cell Signaling

	BAFF in B-Cell Signaling	1.00			RANK Signaling in Osteoclasts	0.45
	APRIL Pathway	0.92

B cell receptor signaling pathway

	B cell receptor signaling pathway	1.00			PI3K Signaling in B-Lymphocyte	0.35
	T cell receptor signaling pathway	0.40

Immune response_NFAT in immune response

Immune response_NFAT in immune response

1.00

Immune response NFAT in immune response

0.91

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for NFATC3

	Immune response CD28 signaling
	Signal transduction JNK pathway
	Immune response NFAT in immune response
	Immune response T cell receptor signaling pathway
	Signal transduction Activation of PKC via G-Protein coupled receptor

1 R&D Systems Pathway for NFATC3

Wnt Signaling Pathway

5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFATC3 (see all 29)

	PKA Signaling
	Intracellular Calcium Signaling
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway
	PI3K Signaling in B-Lymphocyte

1 Cell Signaling Technology (CST) Pathway for NFATC3

Lymphocyte Signaling

5 GeneGo (Thomson Reuters) Pathways for NFATC3

	Signal transduction Activation of PKC via G-Protein coupled receptor
	Signal transduction JNK pathway
	Immune response T cell receptor signaling pathway
	Immune response CD28 signaling
	Immune response NFAT in immune response

5/8 BioSystems Pathways for NFATC3 (see all 8)

	Heart Development
	B Cell Receptor Signaling Pathway
	Calcium signaling in the CD4+ TCR pathway
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	FOXM1 transcription factor network

1 Reactome Pathway for NFATC3

Calcineurin Dephosphorylates NFATC1/2/3

5/6 Kegg Pathways (Kegg details for NFATC3) (see all 6):

	Wnt signaling pathway
	Axon guidance
	VEGF signaling pathway
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway

NFATC3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NFATC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for NFATC3 (Q12968³ ENSP00000300659⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK9	P45984³, ENSP00000321410⁴	I2D: score=2 STRING: ENSP00000321410
TTF1	Q15361³, ENSP00000333920⁴	I2D: score=1 STRING: ENSP00000333920
CSNK1A1	P48729³, ENSP00000261798⁴	I2D: score=2 STRING: ENSP00000261798
FOS	P01100³, ENSP00000306245⁴	I2D: score=2 STRING: ENSP00000306245
NCOA3	Q9Y6Q9³, ENSP00000361066⁴	I2D: score=1 STRING: ENSP00000361066

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	7749981
GO:0006366	transcription from RNA polymerase II promoter	TAS	7739550
GO:0006954	inflammatory response	TAS	7739550

NFATC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NFATC3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NFATC3

1 HMDB Compound for NFATC3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

4 Novoseek chemical compound relationships for NFATC3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ionomycin	54.4	3	18463795 (1), 11278965 (1)
cyclosporin a	43.6	3	19592461 (1), 9498773 (1), 10887328 (1)
tacrolimus	43.3	2	18463795 (1), 11278965 (1)
calcium	31.7	9	12954637 (3), 12671993 (1), 7739550 (1), 11278965 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about NFATC3 / NFAC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NFATC3 gene (4 alternative transcripts):

NM_004555.3 NM_173163.2 NM_173165.2 NM_173164.1

Unigene Cluster for NFATC3:

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Hs.436585 [show with all ESTs]

Unigene Representative Sequence: NM_004555

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000553077(uc010vkl.2) ENST00000569766 ENST00000563319 ENST00000549350(uc010vko.2)

ENST00000566301 ENST00000566893 ENST00000575270 ENST00000561714 ENST00000568466

ENST00000539828(uc002evl.3) ENST00000562171 ENST00000349223(uc002evm.2 uc002evn.2 uc002evo.2)

ENST00000379165(uc002evk.3 uc010vkr.2 uc010vku.2 uc010vkx.2)

ENST00000346183(uc010vkm.2 uc010vkq.2 uc010vks.2 uc010vkv.2 uc010vky.2 uc010vlb.2)

ENST00000329524(uc010vkn.2 uc010vkp.2 uc010vkt.2 uc010vkw.2 uc010vkz.2 uc010vlc.2)

ENST00000570212 ENST00000562926 ENST00000567152

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		8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate NFATC3 (see all 96):
		hsa-miR-579 hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-376b hsa-miR-15a hsa-miR-30d hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: NFATC3 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 3): NFATC3 (NM_173163)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFATC3

Additional cDNA sequence:

AK290370.1 BC001050.2 EU887605.1 EU887606.1 EU887608.1 EU887609.1 EU887611.1 EU887612.1

EU887614.1 EU887615.1 EU887617.1 EU887618.1 EU887620.1 EU887621.1 EU887623.1 EU887624.1

L41067.1 U14510.1 U85428.1 U85429.1

24/32 DOTS entries (see all 32):

DT.80100987 DT.92415710 DT.99986182 DT.92435502 DT.100037863 DT.120665159 DT.97847233 DT.95193785

DT.120665072 DT.100818860 DT.92458544 DT.120664961 DT.120665170 DT.40131967 DT.92458546 DT.95148454

DT.95148459 DT.120664996 DT.427060 DT.91647134 DT.92458562 DT.95148461 DT.100037864 DT.120665076

24/471 AceView cDNA sequences (see all 471):

AI022683 BM976712 BM672189 AI219201 AI598199 BE893770 BU731230 AA661615

L41067 AA613587 BU527356 BE407644 NM_173163 AI276927 AW294267 AA131942

BU739910 BM979650 AJ709133 AI423227 BC001050 T36047 AI672917 BU951323

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NFATC3 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15
SP1:					-		-		-																										-
SP2:					-		-		-																								-
SP3:					-		-		-																								-		-
SP4:					-		-		-		-		-		-		-		-
SP5:							-		-

ECgene alternative splicing isoforms for NFATC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NFATC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTCTCCT

About this image

NFATC3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Cardiomyocytes

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NFATC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NFATC3

SOURCE GeneReport for Unigene cluster: Hs.436585

UniProtKB/Swiss-Prot: NFAC3_HUMAN, Q12968

Tissue specificity: Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and

kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen,

prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4

is expressed in thymus and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including NFATC3 (see all 6):

Stem Cell Signaling in human mouse rat

EGF / PDGF Signaling Pathway in human mouse rat

VEGF Signaling in human mouse rat

Transcription Factors in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NFATC3 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NFATC3¹	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent more	76.71(n) 76.16(a)		415711 XM_414078.3 XP_414078.3
lizard (Anolis carolinensis)	Reptilia	NFATC3⁶	--	70(a)	1 ↔ 1	LGc(6295087-6334390)
African clawed frog (Xenopus laevis)	Amphibia	nf-at²	nuclear factor of activated T-cell	74.75(n)		AB037471.1
zebrafish (Danio rerio)	Actinopterygii	nfatc3¹	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent more	62.3(n) 64.58(a)		561772 XM_685181.5 XP_690273.3

ENSEMBL Gene Tree for NFATC3 (if available)
TreeFam Gene Tree for NFATC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NFATC3 gene

NFATC4² NFATC1² NFAT5² NFATC2²

3 SIMAP similar genes for NFATC3 using alignment to 13 protein entries: NFAC3_HUMAN (see all proteins):

NFATC4 NFATC1 NFATC2

NFATC3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73606403^1,2	C,F,	--	53990697(+)	`CTGCAG/AGTTAC`	3	--	us2k¹		3		WA	122
rs74980876^1,2		--	53990698(+)	`TGCAGG/ATTACT`	3	--	us2k¹		1		WA	118
rs74395075^1,2		--	53991530(+)	`CGGTTA/CTTTAG`	3	--	us2k¹		0	--	--	--	--
rs35831835^1,2	C	--	53991540(+)	`GGCAGT/GGTCAC`	3	--	us2k¹		1		NA	2
rs9933080^1,2	C	--	53992889(+)	`CTCGCA/GGGATC`	3	--	int¹		1		NA	2
rs73606405^1,2	C,F,	--	53993180(+)	`TGTGAA/GTTGTT`	3	--	int¹		3		WA	122
rs117748861^1,2	C,F,	--	53993208(+)	`ATCTAT/CTCTAG`	3	--	int¹		1		NA	120
rs114705468^1,2	C,F,	--	53993309(+)	`TTGCTA/GGAAGA`	3	--	int¹		1		WA	118
rs79744836^1,2		--	53993731(+)	`TCCCTA/GTTTTT`	3	--	int¹		1		NA	120
rs73606407^1,2	C,F,	--	53993909(+)	`CTGTAG/ATACAT`	3	--	int¹		2		WA	4

HapMap Linkage Disequilibrium report for NFATC3 (68118654 - 68263162 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NFATC3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NFATC3 for disorders           About GeneDecksing

OMIM gene information: 602698    OMIM disorders: --

12 diseases for NFATC3:    About MalaCards

north american indian childhood cirrhosis oral squamous cell carcinoma squamous cell carcinoma pulmonary hypertension

hepatitis b hypertension hepatitis carcinoma

hypoxia immunodeficiency thyroiditis prostatitis

Human Genome Epidemiology (HuGE) Navigator: NFATC3 (6 documents)

Export disorders for NFATC3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NFATC3 gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with NFATC3)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. (PubMed id 7749981)^{1, 2, 3} Hoey T.... Xu X. (1995)
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. (PubMed id 9630228)^{1, 2, 9} Zhu J.... McKeon F. (1998)
NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. (PubMed id 7739550)^{1, 2, 9} Masuda E.S.... Arai N. (1995)
Carboxy-terminal 15 amino acids sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells. (PubMed id 9759864)^{1, 2, 9} Imamura R.... Arai N. (1998)
CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. (PubMed id 18815128)^{1, 2} Li G.D....Zhang Y. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2} Loftus B.J.... Adams M.D. (1999)
Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. (PubMed id 10089876)^{1, 2} Crabtree G.R. (1999)
Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets. (PubMed id 9498773)^{1, 9} Amasaki Y....Arai N. (1998)
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. (PubMed id 9374467)^{1, 9} Chow C.W....Davis R.J. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4775	HGNC: 7777	AceView: NFATC3	Ensembl:ENSG00000072736	euGenes: HUgn4775
ECgene: NFATC3	Kegg: 4775	H-InvDB: NFATC3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NFATC3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NFATC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NFATC3 gene:
Search GeneIP for patents involving NFATC3

GeneCards and IP:
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