Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NFATC2IP Gene

Aliases for NFATC2IP Gene

  • Nuclear Factor Of Activated T-Cells 2 Interacting Protein 2 3 5
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein 2 3
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic 2-Interacting Protein 3 4
  • 45 KDa NF-AT-Interacting Protein 3 4
  • 45 KDa NFAT-Interacting Protein 3 4
  • NIP45 3 4
  • NFATC2-Interacting Protein 3
  • RAD60 3
  • ESC2 3

External Ids for NFATC2IP Gene

Previous GeneCards Identifiers for NFATC2IP Gene

  • GC16P028870
  • GC16P026830

Summaries for NFATC2IP Gene

GeneCards Summary for NFATC2IP Gene

NFATC2IP (Nuclear Factor Of Activated T-Cells 2 Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NFATC2IP Gene

  • In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFATC2IP Gene

Genomics for NFATC2IP Gene

Regulatory Elements for NFATC2IP Gene


Enhancers around NFATC2IP on UCSC Golden Path with GeneCards custom track

Promoters for NFATC2IP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084950 293 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS

Genomic Location for NFATC2IP Gene

Chromosome:
16
Start:
28,950,807 bp from pter
End:
28,967,097 bp from pter
Size:
16,291 bases
Orientation:
Plus strand

Genomic View for NFATC2IP Gene

Genes around NFATC2IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NFATC2IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NFATC2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFATC2IP Gene

Proteins for NFATC2IP Gene

  • Protein details for NFATC2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCF5-NF2IP_HUMAN
    Recommended name:
    NFATC2-interacting protein
    Protein Accession:
    Q8NCF5
    Secondary Accessions:
    • B7Z4G5
    • Q66K34
    • Q6NVK1
    • Q8NFR2
    • Q96ST9

    Protein attributes for NFATC2IP Gene

    Size:
    419 amino acids
    Molecular mass:
    45817 Da
    Quaternary structure:
    • Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).
    SequenceCaution:
    • Sequence=AAM49721.1; Type=Frameshift; Positions=107, 114; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFATC2IP Gene

    Alternative splice isoforms for NFATC2IP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFATC2IP Gene

Post-translational modifications for NFATC2IP Gene

  • Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFATC2IP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NFATC2IP Gene

Domains & Families for NFATC2IP Gene

Protein Domains for NFATC2IP Gene

Suggested Antigen Peptide Sequences for NFATC2IP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NFATC2IP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NFATC2IP Gene

Function for NFATC2IP Gene

Molecular function for NFATC2IP Gene

UniProtKB/Swiss-Prot Function:
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Gene Ontology (GO) - Molecular Function for NFATC2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031386 protein tag IBA --
genes like me logo Genes that share ontologies with NFATC2IP: view
genes like me logo Genes that share phenotypes with NFATC2IP: view

Animal Models for NFATC2IP Gene

MGI Knock Outs for NFATC2IP:

Animal Model Products

  • Taconic Biosciences Mouse Models for NFATC2IP

CRISPR Products

miRNA for NFATC2IP Gene

miRTarBase miRNAs that target NFATC2IP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NFATC2IP Gene

Localization for NFATC2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFATC2IP Gene

Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NFATC2IP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NFATC2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NFATC2IP: view

Pathways & Interactions for NFATC2IP Gene

SuperPathways for NFATC2IP Gene

No Data Available

Pathways by source for NFATC2IP Gene

1 GeneTex pathway for NFATC2IP Gene

Gene Ontology (GO) - Biological Process for NFATC2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0016925 protein sumoylation IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with NFATC2IP: view

No data available for SIGNOR curated interactions for NFATC2IP Gene

Transcripts for NFATC2IP Gene

Unigene Clusters for NFATC2IP Gene

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFATC2IP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - - -
SP4:
SP5: - - - - - - - - - -
SP6: -
SP7: -
SP8: -

Relevant External Links for NFATC2IP Gene

GeneLoc Exon Structure for
NFATC2IP
ECgene alternative splicing isoforms for
NFATC2IP

Expression for NFATC2IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NFATC2IP Gene

Protein differential expression in normal tissues from HIPED for NFATC2IP Gene

This gene is overexpressed in CD8 Tcells (15.3), Testis (12.2), Fetal ovary (9.3), NK cells (7.4), CD4 Tcells (6.6), Blymphocyte (6.5), and Monocytes (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NFATC2IP Gene



Protein tissue co-expression partners for NFATC2IP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NFATC2IP Gene:

NFATC2IP

SOURCE GeneReport for Unigene cluster for NFATC2IP Gene:

Hs.513470

Evidence on tissue expression from TISSUES for NFATC2IP Gene

  • Nervous system(4.5)
  • Eye(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with NFATC2IP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NFATC2IP Gene

Orthologs for NFATC2IP Gene

This gene was present in the common ancestor of chordates.

Orthologs for NFATC2IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFATC2IP 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia NFATC2IP 34 35
  • 83.95 (n)
cow
(Bos Taurus)
Mammalia NFATC2IP 34 35
  • 81.74 (n)
mouse
(Mus musculus)
Mammalia Nfatc2ip 34 16 35
  • 77.75 (n)
rat
(Rattus norvegicus)
Mammalia Nfatc2ip 34
  • 77.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NFATC2IP 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NFATC2IP 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nfatc2ip 34 35
  • 49.82 (n)
Species where no ortholog for NFATC2IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFATC2IP Gene

ENSEMBL:
Gene Tree for NFATC2IP (if available)
TreeFam:
Gene Tree for NFATC2IP (if available)

Paralogs for NFATC2IP Gene

(3) SIMAP similar genes for NFATC2IP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFATC2IP: view

No data available for Paralogs for NFATC2IP Gene

Variants for NFATC2IP Gene

Sequence variations from dbSNP and Humsavar for NFATC2IP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000024985 -- 28,949,773(+) ACCTC(A/T)GCCTC upstream-variant-2KB
rs1000558574 -- 28,954,988(+) AACCC(C/T)GTTTT intron-variant
rs1000777265 -- 28,960,915(+) GATAG(A/G)AGATT intron-variant
rs1000801723 -- 28,960,619(+) CATAG(A/G)ATAGA intron-variant
rs1001020308 -- 28,967,386(+) CACTC(C/G)AGCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NFATC2IP Gene

Variant ID Type Subtype PubMed ID
dgv2830n100 CNV gain 25217958
dgv2831n100 CNV gain 25217958
dgv4987n54 CNV gain 21841781
esv2758640 CNV gain+loss 17122850
esv33811 CNV loss 17666407
esv3570454 CNV gain 25503493
esv3892826 CNV gain+loss 25118596
nsv1059555 CNV gain 25217958
nsv457480 CNV gain 19166990
nsv518648 CNV loss 19592680
nsv519100 CNV gain 19592680
nsv571805 CNV loss 21841781
nsv571808 CNV gain 21841781

Variation tolerance for NFATC2IP Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NFATC2IP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NFATC2IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFATC2IP Gene

Disorders for NFATC2IP Gene

Relevant External Links for NFATC2IP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NFATC2IP

No disorders were found for NFATC2IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NFATC2IP Gene

Publications for NFATC2IP Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. (PMID: 15698469) Novatchkova M. … Eisenhaber F. (BMC Bioinformatics 2005) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NFATC2IP Gene

Sources for NFATC2IP Gene

Content
Loading form....