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Aliases for NFATC2IP Gene

Aliases for NFATC2IP Gene

  • Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein 2 3
  • NIP45 3 4 6
  • Nuclear Factor Of Activated T-Cells, Cytoplasmic 2-Interacting Protein 3 4
  • 45 KDa NF-AT-Interacting Protein 3 4
  • 45 KDa NFAT-Interacting Protein 3 4
  • NFATC2-Interacting Protein 3
  • RAD60 3
  • ESC2 3

External Ids for NFATC2IP Gene

Previous GeneCards Identifiers for NFATC2IP Gene

  • GC16P028870
  • GC16P026830

Summaries for NFATC2IP Gene

GeneCards Summary for NFATC2IP Gene

NFATC2IP (Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NFATC2IP Gene

  • In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFATC2IP Gene

Genomics for NFATC2IP Gene

Regulatory Elements for NFATC2IP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFATC2IP Gene

Start:
28,950,807 bp from pter
End:
28,967,097 bp from pter
Size:
16,291 bases
Orientation:
Plus strand

Genomic View for NFATC2IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFATC2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFATC2IP Gene

Proteins for NFATC2IP Gene

  • Protein details for NFATC2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCF5-NF2IP_HUMAN
    Recommended name:
    NFATC2-interacting protein
    Protein Accession:
    Q8NCF5
    Secondary Accessions:
    • B7Z4G5
    • Q66K34
    • Q6NVK1
    • Q8NFR2
    • Q96ST9

    Protein attributes for NFATC2IP Gene

    Size:
    419 amino acids
    Molecular mass:
    45817 Da
    Quaternary structure:
    • Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).
    SequenceCaution:
    • Sequence=AAM49721.1; Type=Frameshift; Positions=107, 114; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NFATC2IP Gene

    Alternative splice isoforms for NFATC2IP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NFATC2IP Gene

Proteomics data for NFATC2IP Gene at MOPED

Post-translational modifications for NFATC2IP Gene

  • Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFATC2IP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NFATC2IP Gene

Domains for NFATC2IP Gene

Protein Domains for NFATC2IP Gene

Suggested Antigen Peptide Sequences for NFATC2IP Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCF5

UniProtKB/Swiss-Prot:

NF2IP_HUMAN :
  • Q8NCF5
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with NFATC2IP: view

No data available for Gene Families for NFATC2IP Gene

Function for NFATC2IP Gene

Molecular function for NFATC2IP Gene

UniProtKB/Swiss-Prot Function: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Gene Ontology (GO) - Molecular Function for NFATC2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NFATC2IP: view

Phenotypes for NFATC2IP Gene

genes like me logo Genes that share phenotypes with NFATC2IP: view

Animal Models for NFATC2IP Gene

MGI Knock Outs for NFATC2IP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFATC2IP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NFATC2IP Gene

Localization for NFATC2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFATC2IP Gene

Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NFATC2IP Gene COMPARTMENTS Subcellular localization image for NFATC2IP gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NFATC2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NFATC2IP: view

Pathways for NFATC2IP Gene

SuperPathways for NFATC2IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFATC2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with NFATC2IP: view

No data available for Pathways by source for NFATC2IP Gene

Transcripts for NFATC2IP Gene

Unigene Clusters for NFATC2IP Gene

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFATC2IP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NFATC2IP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFATC2IP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - - -
SP4:
SP5: - - - - - - - - - -
SP6: -
SP7: -
SP8: -

Relevant External Links for NFATC2IP Gene

GeneLoc Exon Structure for
NFATC2IP
ECgene alternative splicing isoforms for
NFATC2IP

Expression for NFATC2IP Gene

mRNA expression in normal human tissues for NFATC2IP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NFATC2IP Gene

SOURCE GeneReport for Unigene cluster for NFATC2IP Gene Hs.513470

genes like me logo Genes that share expressions with NFATC2IP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NFATC2IP Gene

Orthologs for NFATC2IP Gene

This gene was present in the common ancestor of chordates.

Orthologs for NFATC2IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NFATC2IP 35
  • 99.12 (n)
  • 98.33 (a)
NFATC2IP 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NFATC2IP 35
  • 81.74 (n)
  • 77.52 (a)
NFATC2IP 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NFATC2IP 35
  • 83.95 (n)
  • 78.99 (a)
NFATC2IP 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nfatc2ip 35
  • 77.75 (n)
  • 72.82 (a)
Nfatc2ip 16
Nfatc2ip 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NFATC2IP 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nfatc2ip 35
  • 77.72 (n)
  • 71.67 (a)
lizard
(Anolis carolinensis)
Reptilia NFATC2IP 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nfatc2ip 35
  • 49.82 (n)
  • 39.27 (a)
nfatc2ip 36
  • 31 (a)
OneToOne
Species with no ortholog for NFATC2IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFATC2IP Gene

ENSEMBL:
Gene Tree for NFATC2IP (if available)
TreeFam:
Gene Tree for NFATC2IP (if available)

Paralogs for NFATC2IP Gene

Selected SIMAP similar genes for NFATC2IP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NFATC2IP: view

No data available for Paralogs for NFATC2IP Gene

Variants for NFATC2IP Gene

Sequence variations from dbSNP and Humsavar for NFATC2IP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1138309 -- 28,954,914(+) AGTAA(A/T)GTGAG intron-variant
rs1138670 -- 28,953,654(+) ctcaa(A/G)gtgct intron-variant
rs7201257 - 28,951,108(+) GTCCT(C/T)GGGCC reference, missense
rs7498839 -- 28,953,762(+) aaaaa(A/T)aaaaa intron-variant
rs8045247 -- 28,949,654(+) ttaaa(C/T)aaatg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NFATC2IP Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
nsv905700 CNV Loss 21882294
nsv905702 CNV Gain+Loss 21882294
nsv518648 CNV Loss 19592680
nsv519100 CNV Gain 19592680
nsv457480 CNV Gain 19166990
esv33811 CNV Loss 17666407

Relevant External Links for NFATC2IP Gene

HapMap Linkage Disequilibrium report
NFATC2IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFATC2IP Gene

Disorders for NFATC2IP Gene

No disorders were found for NFATC2IP Gene.

No data available for UniProtKB/Swiss-Prot for NFATC2IP Gene

Publications for NFATC2IP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. (PMID: 15698469) Novatchkova M. … Eisenhaber F. (BMC Bioinformatics 2005) 2 3
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for NFATC2IP Gene

Sources for NFATC2IP Gene

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