NFATC2 Gene
protein-coding GIFtS: 64
GCID: GC20M050003
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nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent...
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Aliases
for NFATC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent21 2 | | NFAT Transcription Complex, Preexisting Component2 | | NFAT11 2 3 | | Nuclear Factor Of Activated T-Cells, Cytoplasmic 22 | | NFATP2 3 5 | | Nuclear Factor Of Activated T-Cells, Preexisting Component2 | | NF-ATc22 3 | | Preexisting Nuclear Factor Of Activated T-Cells 22 | | NFAT Pre-Existing Subunit2 3 | | T Cell Transcription Factor NFAT12 | | T-Cell Transcription Factor NFAT12 3 | | NF-ATp3 | | NF-ATP1 | | NFATc23 | | NFATp1 | | |
Export aliases for NFATC2 gene to outside databasesPrevious GC identifers: GC20M049743 GC20M050646 GC20M050693 GC20M049442 GC20M046756 |
Summaries
for NFATC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NFATC2:
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is aDNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in thecytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of thenuclear factors of activated T cells transcription complex. This complex plays a central role in inducing genetranscription during the immune response. Alternate transcriptional splice variants encoding different isoforms havebeen characterized. (provided by RefSeq, Apr 2012)
UniProtKB/Swiss-Prot: NFAC2_HUMAN, Q13469Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of theIL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5Asignaling pathway
Gene Wiki entry for NFATC2
|
Genomic Views
for NFATC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NFATC2 gene promoter:
Elk-1 c-Rel NF-kappaB1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for NFATC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFATC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.2 HGNC cytogenetic band: 20q13.2NFATC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M050003: view genomic region
(about GC identifiers)
Start:
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50,003,494 bp from pter |
End:
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50,179,168 bp from pter |
Size:
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175,675 bases |
Orientation:
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minus strand |
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Proteins
for NFATC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NFAC2_HUMAN, Q13469 (See
protein sequence)Recommended Name: Nuclear factor of activated T-cells, cytoplasmic 2 Size: 925 amino acids; 100146 Da
Subunit: Member of the multicomponent NFATC transcription complex that consists of at least two components, apre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4,NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. Thephosphorylated form specifically interacts with XPO1; which mediates nuclear export. NFATC proteins bind to DNA asmonomers. Interacts with NFATC2IP (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activationthat is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be onemechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization ofNFATC plays a key role in the regulation of gene transcription
6/8 PDB 3D structures from  and Proteopedia  for NFATC2 (see all 8):1A02 (3D)
1OWR (3D)
1P7H (3D)
1PZU (3D)
1S9K (3D)
2AS5 (3D)
Secondary accessions: B5B2N8 B5B2N9 Q13468 Q5TFW7 Q5TFW8 Q9NPX6 Q9NQH3 Q9UJR2Alternative splicing: 3 isoforms: Q13469-1 Q13469-2 Q13469-3 Explore the universe of human proteins at neXtProt for NFATC2: NX_Q13469
Post-translational modifications:
In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, allthese sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change thatsimultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 orSer-56 is phosphorylated; which is required for full transcriptional activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13469
NFATC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_001129493.1 NP_001245221.1 NP_001245223.1 NP_001245224.1 NP_001245225.1 NP_001245226.1 NP_036472.2 NP_775114.1
ENSEMBL proteins: ENSP00000360619 ENSP00000379330 ENSP00000396471 Reactome Protein details: Q13469
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
NFATC2 for ontologies About GeneDecksing
NFATC2 Antibody Products:
Assay Products for NFATC2: |
Protein
Domains /
Families
for NFATC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NFATC2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13469ProtoNet protein and cluster: Q13469 3 Blocks protein families: IPB002909 Cell surface receptor IPT/TIG IPB008366 Nuclear factor of activated T cells (NFAT) signature IPB011539 Rel homology
UniProtKB/Swiss-Prot: NFAC2_HUMAN, Q13469Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcriptionfactorsDomain: Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity)Similarity: Contains 1 RHD (Rel-like) domain |
Function
for NFATC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NFAC2_HUMAN, Q13469Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of theIL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5Asignaling pathwayInduction: Inducibly expressed in T-lymphocytes upon activation of the T-cell receptor (TCR) complex. Induced afterco-addition of phorbol 12-myristate 13-acetate (PMA) and ionomycin Genatlas biochemistry entry for NFATC2:nuclear factor activated T cells c2,pre-existing,component,related to the NFKB/REL proteins and forming cooperativecomplexes with FOS and JUN on DNA,calcineurin dependent,involved in expression of genes collectively coordinatingimmune response
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC2 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NFATC2 (NM_173091) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NFATC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFATC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFATC2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NFATC2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NFATC2:
Animal Models:
Mouse knock-outs for NFATC2: Nfatc2tm1Srf Nfatc2tm1Glm Nfatc2tm1Rao
12 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Nfatc2):
NFATC2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NFATC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways - 5/45 super-pathways (see all 45) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | BAFF in B-Cell Signaling | | | 2 | Immune response_IL-2 activation and signaling pathway | | | 3 | Activation of cAMP-Dependent PKA | | | 4 | PKC-Theta Pathway | | | 5 | B cell receptor signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/13 EMD Millipore Pathways for NFATC2 (see all 13)
1  R&D Systems Pathway for NFATC2
5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NFATC2 (see all 31)
1 
Cell Signaling Technology (CST) Pathway for NFATC2
5/13  GeneGo (Thomson Reuters) Pathways for NFATC2 (see all 13)
5/10  BioSystems Pathways for NFATC2 (see all 10)
1 
Reactome Pathway for NFATC2
1  PharmGKB Pathway for NFATC2
5/8 
Kegg Pathways (Kegg details for NFATC2) (see all 8):
NFATC2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NFATC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/99 Interacting proteins for NFATC2 (Q134691, 2, 3 ENSP000003793304) via UniProtKB, MINT, STRING, and/or I2D (see all 99)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
NFATC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NFATC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NFATC2 for compounds About GeneDecksing
 Browse Tocris compounds for NFATC2
1 HMDB Compound for NFATC2 About this table
7 Novoseek chemical compound relationships for NFATC2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ionomycin |
68 |
20 |
8668213 (3), 11982754 (2), 8631904 (2), 9111316 (2) (see all 7) |
| cyclosporin a |
67.1 |
39 |
11982754 (3), 8668213 (3), 7657645 (3), 7650486 (2) (see all 17) |
| tacrolimus |
53 |
6 |
11982754 (3), 8631904 (1), 12594826 (1) |
| calcium |
35.6 |
13 |
10940935 (2), 16172401 (2), 8668212 (1), 11982754 (1) (see all 8) |
| cyclic amp |
8.82 |
1 |
8816436 (1) |
| oligonucleotide |
0 |
1 |
11320240 (1) |
| vitamin d |
0 |
1 |
10330159 (1) |
Search CenterWatch for drugs/clinical trials and news about NFATC2 / NFAC2
|
Transcripts
for NFATC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NFATC2 gene (8 alternative transcripts): NM_001136021.2 NM_001258292.1 NM_001258294.1 NM_001258295.1 NM_001258296.1 NM_001258297.1 NM_012340.4 NM_173091.3 Unigene Cluster for NFATC2: Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 Hs.744148 [show with all ESTs]Unigene Representative Sequence: NM_0123404 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371564(uc002xwc.3 uc010zyv.2) ENST00000396009(uc002xwd.3 uc010zyw.2)
ENST00000496054 ENST00000414705(uc010zyx.2 uc010zyy.2 uc010zyz.2 uc002xwe.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC2 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NFATC2 (NM_173091) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NFATC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFATC2 |
Additional cDNA sequence: AK025758.1 AK226146.1 AK304147.1 AY927566.1 BC136418.1 BC144074.1 EU887573.1 EU887574.1 EU887575.1 EU887576.1 EU887577.1 EU887578.1 EU887579.1 EU887580.1 FJ573259.1 FJ573260.1 U43341.1 U43342.1 5 DOTS entries: DT.313953 DT.100754220 DT.91753121 DT.95208979 DT.99969200 24/103 AceView cDNA sequences (see all 103): BX279897 BM977026 NM_012340 AW518114 AA814436 AI365196 AI191843 AU185751 AA740241 AW028983 AA886395 AW008188 AI458188 AI192984 AA648810 AA491103 CA449812 BQ006208 AA490916 BM766967 NM_173091 AA746235 BM822689 BF196861
GeneLoc Exon Structure
|
Expression
for NFATC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NFATC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATATTTCC
About this image
See NFATC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NFATC2
SOURCE GeneReport for Unigene cluster: Hs.744148
UniProtKB/Swiss-Prot: NFAC2_HUMAN, Q13469Tissue specificity: Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 ishighly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highlyexpressed in stomach, uterus, placenta, trachea and thyroid
SABiosciences Expression via Pathway-Focused PCR Arrays including NFATC2 (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFATC2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFATC2 |
Orthologs
for NFATC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NFATC2 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for NFATC2 (if available)
TreeFam Gene Tree for NFATC2 (if available) |
Paralogs
for NFATC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NFATC2 gene
- NFATC32 NFATC42 NFATC12 NFAT52
2 SIMAP similar genes for NFATC2 using alignment to 5 protein entries: NFAC2_HUMAN (see all proteins):NFATC1 NFATC3
NFATC2 for paralogs About GeneDecksing
|
Genomic Variants
for NFATC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NFATC2 (50003494 - 50179168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NFATC2
2 CNVs: 8888 102985 | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing NFATC2: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFATC2 |
|
Disorders
/ Diseases
for NFATC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NFATC2 for disorders About GeneDecksing
OMIM gene information: 600490
OMIM disorders: --
20/33  diseases for NFATC2 (see all 33): About MalaCardswiskott-aldrich syndrome bullous pemphigoid lupus erythematosus b-cell lymphomas
enchondroma systemic lupus erythematosus aplastic anemia hypereosinophilic syndrome
chronic lymphocytic leukemia lymphocytic leukemia burkitt's lymphoma colon carcinoma
pulmonary hypertension hemangioma hepatitis b chondrosarcoma
breast cancer anemia hypertension alzheimer's disease
8 Novoseek disease relationships for NFATC2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: NFATC2 (10 documents)
Export disorders for NFATC2 gene to outside databases
|
Publications
for NFATC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NFATC2 gene, integrated from 9 sources (see all 238):
(articles sorted by number of sources associating them with NFATC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. (PubMed id 8668213)1, 2, 9 Luo C.... Rao A. (1996)
- Alternative splicing and expression of human and mouse NFAT genes. (PubMed id 18675896)1, 2, 9 Vihma H.... Timmusk T. (2008)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. (PubMed id 10089876)1, 2 Crabtree G.R. (1999)
- NF-AT components define a family of transcription factors targeted in T-cell activation. (PubMed id 8202141)1, 3 Northrop J.P.... Crabtree G.R. (1994)
- Characterization of DNA binding, transcriptional acti vation, and regulated nuclear association of recombinant human NFATp. (PubMed id 11231878)1, 9 Kim L.J....Goodrich J.A. (2000)
- Cot/Tpl2 and PKCzeta cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain. (PubMed id 17398070)1, 9 Gomez-Casero E....Fresno M. (2007)
- Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. (PubMed id 15117942)1, 9 Terui Y....Yuan J. (2004)
- Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. (PubMed id 11982754)1, 9 Al-Daraji W.I....Reynolds N.J. (2002)
|
External Searches for NFATC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NFATC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NFATC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NFATC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NFATC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NFATC2 gene:
Search GeneIP for patents involving NFATC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NFATC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for NFATC2 | | OriGene shRNA RFP for NFATC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NFATC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NFATC2 | | | OriGene Protein Over-expression Lysate for NFATC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NFATC2 | | OriGene 3'-UTR Clone for NFATC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NFATC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NFATC2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NFATC2 | | OriGene Custom Protein Services for NFATC2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NFATC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NFATC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NFATC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NFATC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NFATC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NFATC2 |
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| | Antibodies & Assays for NFATC2 (NFAT1) |
| | | | Search Tocris compounds for NFATC2 |
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 | | | NFATC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NFATC2 |
|  |  |  | | | | ThermoFisher Antibody for NFATC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NFATC2 |
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