Aliases for NFATC2 Gene
External Ids for NFATC2 Gene
Previous GeneCards Identifiers for NFATC2 Gene
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
GeneCards Summary for NFATC2 Gene
NFATC2 (Nuclear Factor Of Activated T-Cells 2) is a Protein Coding gene. Diseases associated with NFATC2 include Leukostasis and Fibrosarcoma Of Bone. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and RANK Signaling in Osteoclasts. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NFATC1.
UniProtKB/Swiss-Prot for NFATC2 Gene
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.
NFAT (Nuclear Factor of Activated T-Cells) proteins are transcription factors that are integral for the development and function of the immune system. Five NFAT isoforms have been identified to date, NFATC1-C4 and NFAT5.