Aliases for NFATC2 Gene
External Ids for NFATC2 Gene
Previous GeneCards Identifiers for NFATC2 Gene
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
GeneCards Summary for NFATC2 Gene
NFATC2 (Nuclear Factor Of Activated T-Cells 2) is a Protein Coding gene. Diseases associated with NFATC2 include Leukostasis and Fibrosarcoma Of Bone. Among its related pathways are RANK Signaling in Osteoclasts and Immune response NFAT in immune response. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NFATC1.
UniProtKB/Swiss-Prot for NFATC2 Gene
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.
NFAT (Nuclear Factor of Activated T-Cells) proteins are transcription factors that are integral for the development and function of the immune system. Five NFAT isoforms have been identified to date, NFATC1-C4 and NFAT5.