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NFAM1 Gene

protein-coding   GIFtS: 46
GCID: GC22M042776

NFAT Activating Protein With ITAM Motif 1

  Search for NFAM1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NFAT Activating Protein With ITAM Motif 11 2     bK126B4.42
CNAIP2 3 5     Calcinerin/NFAT-Activating ITAM-Containing Protein2
Calcineurin/NFAT-Activating ITAM-Containing Protein2 3     NFAT Activation Molecule 12
NFAT-Activating Protein With ITAM Motif 12 3     

External Ids:    HGNC: 298721   Entrez Gene: 1503722   Ensembl: ENSG000002355687   OMIM: 6087405   UniProtKB: Q8NET53   

Export aliases for NFAM1 gene to outside databases

Previous GC identifers: GC22M039378 GC22M041007 GC22M041009 GC22M041100 GC22M025742


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NFAM1 Gene:
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the
IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif
(ITAM) and is thought to regulate the signaling and development of B-cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for NFAM1 Gene:
NFAM1 (NFAT activating protein with ITAM motif 1) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot: NFAM1_HUMAN, Q8NET5
Function: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway
the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be
involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors
without ligand binding or antibody cross-linking




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NFAM1 gene promoter:
         RelA   CUTL1   NF-kappaB   GATA-1   GATA-2   POU2F1   Zic1   POU2F1a   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNFAM1 promoter sequence
   Search Chromatin IP Primers for NFAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NFAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

NFAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NFAM1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M042776:  view genomic region     (about GC identifiers)

Start:
42,776,413 bp from pter      End:
42,828,401 bp from pter
Size:
51,989 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NFAM1_HUMAN, Q8NET5 (See protein sequence)
Recommended Name: NFAT activation molecule 1 precursor  
Size: 270 amino acids; 29686 Da
Subunit: No direct interaction with the B-cell antigen receptor (BCR). Interacts with SYK; probably involved in
BCR signaling. Interacts with ZAP70 (By similarity)
Secondary accessions: B0QYD0 Q20WL2 Q5JZ96 Q8IUY8 Q8TEM8

Explore the universe of human proteins at neXtProt for NFAM1: NX_Q8NET5

Explore proteomics data for NFAM1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn107
  • Modification sites at PhosphoSitePlus

  • See NFAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_666017.1  
    ENSEMBL proteins: 
     ENSP00000333680   ENSP00000347650  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003110 Phos_immunorcpt_sig_ITAM
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8NET5

    ProtoNet protein and cluster: Q8NET5

    2 Blocks protein domains:
    IPB003110 Phosphorylated immunoreceptor signaling ITAM
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: NFAM1_HUMAN, Q8NET5
    Domain: The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions.
    The phosphorylated ITAM domain binds ZAP70 and SYK
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
    Similarity: Contains 1 ITAM domain


    NFAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NFAM1_HUMAN, Q8NET5
    Function: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway
    the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be
    involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors
    without ligand binding or antibody cross-linking

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IDA12615919
         
    NFAM1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NFAM1
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    hsa-miR-875-3p hsa-miR-4288 hsa-miR-1224-3p hsa-miR-605 hsa-miR-632 hsa-miR-346 hsa-miR-513c hsa-miR-1205
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NFAM1_HUMAN, Q8NET5: Cell membrane; Single-pass type I membrane protein (By similarity). Note=Partially recruited
    to lipid rafts upon BCR stimulation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion2
    cytosol1
    extracellular1
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IDA12615919
    GO:0045121membrane raft IEA--

    NFAM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NFAM1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NFAM1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NFAM1 (Q8NET53 ENSP000003336804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434053, ENSP000003648984I2D: score=2 STRING: ENSP00000364898
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001819positive regulation of cytokine production NAS12615919
    GO:0006954inflammatory response NAS12615919
    GO:0007165signal transduction IDA12615919
    GO:0007166cell surface receptor signaling pathway ----
    GO:0030183B cell differentiation ISS15143214

    NFAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NFAM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NFAM1 gene: 
    NM_145912.5  

    Unigene Cluster for NFAM1:

    NFAT activating protein with ITAM motif 1
    Hs.436677  [show with all ESTs]
    Unigene Representative Sequence: NM_145912
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329021(uc003bcn.4) ENST00000355469
    miRNA
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    hsa-miR-875-3p hsa-miR-4288 hsa-miR-1224-3p hsa-miR-605 hsa-miR-632 hsa-miR-346 hsa-miR-513c hsa-miR-1205
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      QuantiFast Probe-based Assays in human, mouse, rat NFAM1

    Additional mRNA sequence: 

    AK074094.1 AK097971.1 AY121370.1 AY247409.1 BC038241.1 CT841509.1 

    4 DOTS entries:

    DT.95155006  DT.70103199  DT.95350222  DT.95316763 

    Selected AceView cDNA sequences (see all 46):

    AI651781 BI822131 AY121370 AY247409 NM_145912 H55271 BU584078 BU584310 
    BC038241 BI910588 BI912309 BU584318 AI591214 AI565667 AK097971 BF431893 
    AI565658 AI492017 BQ017181 BF509798 AW513682 AI565657 AI337315 AW271350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NFAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NFAM1 Expression
    About this image


    NFAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Monocytes Peripheral Blood
             neutrophils   
     
     Bone (Muscoskeletal System)
             bone marrow   
    NFAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NFAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436677

    UniProtKB/Swiss-Prot: NFAM1_HUMAN, Q8NET5
    Tissue specificity: Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and
    lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue

        Pathway & Disease-focused RT2 Profiler PCR Array including NFAM1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NFAM1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nfam11 , 5 Nfat activating molecule with ITAM motif 11, 5 63.74(n)1
    50.88(a)1
      15 (39.01 cM)5
    740391  NM_001271411.11  NP_001258340.11 
     829977215 
    chicken
    (Gallus gallus)
    Aves NFAM11 NFAT activating protein with ITAM motif 1 49.11(n)
    36.1(a)
      417979  XM_416217.3  XP_416217.2 
    lizard
    (Anolis carolinensis)
    Reptilia NFAM16
    NFAT activating protein with ITAM motif 1
    27(a)
    1 ↔ 1
    GL343614.1(94033-116901)


    ENSEMBL Gene Tree for NFAM1 (if available)
    TreeFam Gene Tree for NFAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NFAM1 (see all 1278)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616210211,2
    C--26709197(+) TATAT-/ATAT  
            
    CTCAC
    1 -- int11Minor allele frequency- ATAT:0.00NA 2
    rs1124261351,2
    F--42775913(+) AACCTC/TGGGGC 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs610181431,2
    C--42775914(+) ACCTCG/AGGGCC 1 -- ds50013Minor allele frequency- A:0.09NA EA 242
    rs48221211,2
    C,F,A,H--42775948(+) GAACAT/GTGAAC 1 -- ds50015Minor allele frequency- G:0.49NA WA EA 362
    rs2008556141,2
    --42775948(+) GAACA-/GTGAAC 1 -- ds50010--------
    rs48221221,2
    C,F,A,H--42775949(+) AACAGA/TGAACT 1 -- ds50015Minor allele frequency- T:0.49NA WA EA 362
    rs1510253421,2
    --42775954(+) TGAACG/TTCTAT 1 -- ds50010--------
    rs1409352991,2
    --42775993(+) TTCCCA/GTAGGG 1 -- ds50010--------
    rs1173809111,2
    C,F--42776175(+) GTCTCC/TGGCAG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1826791321,2
    --42776190(+) CACCAC/TGTGGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NFAM1 (42776413 - 42828401 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NFAM1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724279CNV Deletion23290073
    esv2724282CNV Deletion23290073
    esv2724281CNV Deletion23290073
    esv2724280CNV Deletion23290073
    nsv915171CNV Loss21882294
    nsv915169CNV Loss21882294
    nsv9909CNV Loss18304495
    nsv834211CNV Loss17160897
    nsv428391CNV Gain18775914
    nsv829244CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NFAM1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608740    OMIM disorders: --


    NFAM1 for disorders           About GeneDecksing


    Export disorders for NFAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NFAM1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with NFAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway. (PubMed id 12615919)1, 2, 3, 9 Yang J.... Yao Z. (J. Biol. Chem. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. (PubMed id 15143214)1, 2 Ohtsuka M.... Saito T. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (DNA Res. 2003)
    5. CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PubMed id 18295596)1 Schneider H. and Rudd C.E. (Biochem. Biophys. Res. Commun. 2008)
    6. Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection. (PubMed id 18031784)1 Manley K....Atwood W.J. (Virology 2008)
    7. Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation. (PubMed id 17079331)1 Nilsson L.M....Gomez M.F. (Am. J. Physiol., Cell Physiol. 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (Genome Biol. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150372 HGNC: 29872 AceView: NFAM1 Ensembl:ENSG00000235568 euGenes: HUgn150372
    ECgene: NFAM1 H-InvDB: NFAM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NFAM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NFAM1 gene:
    Search GeneIP for patents involving NFAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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