Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NF1 Gene

protein-coding   GIFtS: 68
GCID: GC17P029421

neurofibromin 1
 Explore 110 diseases affiliated with
NF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NF1    

Aliases
for NF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neurofibromin 11 2
Neurofibromatosis-Related Protein NF-12 3
NFNS2 5
VRNF2 5
WSS2 5
Neurofibromin1

External Ids:    HGNC: 77651   Entrez Gene: 47632   Ensembl: ENSG000001967127   OMIM: 6131135   UniProtKB: P213593   

Export aliases for NF1 gene to outside databases

Previous GC identifers: GC17M029610 GC17P031329 GC17P029271 GC17P029567 GC17P026446 GC17P025632


Summaries
for NF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NF1:
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this
gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for
this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination.
Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NF1_HUMAN, P21359
Function: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity.
May be a regulator of Ras activity

Gene Wiki entry for NF1 (Neurofibromin 1)


Genomic Views
for NF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NF1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

NF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NF1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P029421:  view genomic region     (about GC identifiers)

Start:
 29,421,945 bp from pter      End:
 29,709,134 bp from pter
Size:
 287,190 bases      Orientation:
 plus strand

Proteins
for NF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NF1_HUMAN, P21359 (See protein sequence)
Recommended Name: Neurofibromin  
Size: 2839 amino acids; 319372 Da
Rna editing: Modified_positions=1306; Note=The stop codon (UGA) at position 1306 is created by RNA editing. Various
levels of RNA editing occurs in peripheral nerve-sheath tumor samples (PNSTs) from patients with NF1. Preferentially
observed in transcripts containing exon 23A
Caution: Was originally (PubMed:8807336) thought to be associated with LEOPARD (LS), an autosomal dominant syndrome
Sequence caution: Sequence=AAA59923.1; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for NF1:
1NF1 (3D)        2D4Q (3D)        2E2X (3D)        3P7Z (3D)        3PEG (3D)        3PG7 (3D)    
Secondary accessions: O00662 Q14284 Q14930 Q14931 Q9UMK3
Alternative splicing: 5 isoforms:  P21359-1   P21359-2   P21359-3   P21359-4   P21359-5   

Explore the universe of human proteins at neXtProt for NF1: NX_P21359

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21359

    • NF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_000258.1  NP_001035957.1  NP_001121619.1  

    ENSEMBL proteins: 
     ENSP00000351015   ENSP00000348498   ENSP00000412921   ENSP00000462408   ENSP00000467284  
     ENSP00000463682   ENSP00000389907   ENSP00000463819   ENSP00000462157   ENSP00000467080  
     ENSP00000462700   ENSP00000464678   ENSP00000464702   ENSP00000465138   ENSP00000396481  
     ENSP00000398991  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NF1
    OriGene Custom Protein Services for NF1 
    GenScript Custom Purified and Recombinant Proteins Services for NF1
    Novus Biologicals NF1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NF1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS1550670
    GO:0005737cytoplasm ISS1550670
    GO:0030424axon IDA1550670
    GO:0030425dendrite IDA1550670


    NF1 for ontologies           About GeneDecksing



    NF1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NF1
    Browse R&D Systems for Antibodies
    OriGene Antibodies: NF1
    OriGene Custom Antibody Services for NF1 
    GenScript Superior Antibodies for NF1
    Novus Biologicals NF1 Antibodies
    Search for Antibodies for NF1 at Abcam  
    Uscn Antibodies for NF1
    ThermoFisher Antibody for NF1

    Assay Products for NF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NF1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NF1

    Protein Domains /
    Families
    for NF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NF1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR023152 RasGAP_CS
     IPR001936 RasGAP
     IPR011989 ARM-like
     IPR008936 Rho_GTPase_activation_prot
     IPR001251 CRAL-TRIO_dom

    Graphical View of Domain Structure for InterPro Entry P21359

    ProtoNet protein and cluster: P21359

    2 Blocks protein families:
    IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: NF1_HUMAN, P21359
    Similarity: Contains 1 CRAL-TRIO domain
    Similarity: Contains 1 Ras-GAP domain


    Function
    for NF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NF1_HUMAN, P21359
    Function: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity.
    May be a regulator of Ras activity

         Genatlas biochemistry entry for NF1:
    neurofibromin,Ras GTPase activating protein related (280kDa),signal transduction),with at least four alternatively
    spliced transcripts,with a developmental and tissue specific regulation of expression,also a mRNA editing site in exon
    23 creating an in-frame codon stop,putatively involved in suppression of NF1 tumor and in juvenile myelomonocytic
    leukemia

    miRNA
    Products:            		miRTarBase miRNAs that target NF1:
    hsa-mir-10b (MIRT005504)

    OriGene 3'-UTR Clone (see all 3): NF1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NF1
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate NF1 (see all 100):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NF1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NF1 (see all 7)
    OriGene shRNA RFP: NF1
    OriGene siRNA: NF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NF1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NF1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NF1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NF1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NF1 (NM_002236)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NF1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NF1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NF1
    Search LifeMap BioReagents cell lines for NF1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NF1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IDA1570015
    GO:0005515protein binding IPI16374483


    NF1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for NF1:
     Decreased sensitivity to pacli  Increased cell number in G1, s  Stronger migration  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for NF1: Nf1tm1Fcr Nf1tm2Tyj Nf1tm1Cbr Nf1tm1Tyj Nf1tm1.1Par
         15/23 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Nf1) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    NF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling TC21 regulation pathway
    		G-protein signaling TC21 regulation pathway1.00
    		G-protein signaling_M-RAS regulation pathway0.71
    		G-protein signaling_TC21 regulation pathway1.00
    		G-protein signaling M-RAS regulation pathway0.71
    2Development VEGF signaling via VEGFR2 - generic cascades
    		Development VEGF signaling via VEGFR2 - generic cascades1.00
    		Development_VEGF signaling and activation0.75
    		Development VEGF signaling and activation0.75
    		Development_VEGF signaling via VEGFR2 - generic cascades0.51
    3MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    4pilocytic astrocytoma
    		pilocytic astrocytoma1.00
    5Integrated Breast Cancer Pathway
    		Integrated Breast Cancer Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for NF1
        Development VEGF signaling and activation
    G-protein signaling M-RAS regulation pathway
    G-protein signaling TC21 regulation pathway
    Development VEGF signaling via VEGFR2 - generic cascades

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NF1
        Molecular Mechanisms of Cancer
    Glioblastoma Multiforme

    4 GeneGo (Thomson Reuters) Pathways for NF1
        G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling and activation

    5/7 BioSystems Pathways for NF1 (see all 7) 
        Integrated Breast Cancer Pathway
    MAPK signaling pathway
    Signaling Pathways in Glioblastoma
    pilocytic astrocytoma
    Syndecan-2-mediated signaling events


    1         Kegg Pathway  (Kegg details for NF1):
        MAPK signaling pathway


    NF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    548 Interacting proteins for NF1 (P213591, 2, 3 ENSP000003510154) via UniProtKB, MINT, STRING, and/or I2D (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050671, 3, ENSP000002849814EBI-1172917,EBI-77613 I2D: score=3 STRING: ENSP00000284981
    YWHAEP622582, 3MINT-7947479 I2D: score=1 
    SUMO1P631652, 3, ENSP000003760764MINT-3380416 MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    SDC2P347411, 3, ENSP000003070464EBI-1172917,EBI-1172957 I2D: score=3 STRING: ENSP00000307046
    GRIN1Q055863, ENSP000003606164I2D: score=3 STRING: ENSP00000360616
    DNAJC7Q996153, ENSP000004064634I2D: score=2 STRING: ENSP00000406463
    SMARCA4P515323, ENSP000003507204I2D: score=2 STRING: ENSP00000350720
    TBPL1P623803, ENSP000002372644I2D: score=2 STRING: ENSP00000237264
    GRIN2BQ132243, ENSP000002795934I2D: score=1 STRING: ENSP00000279593
    GRIN2DO153993, ENSP000002632694I2D: score=1 STRING: ENSP00000263269
    SDC3O750563, ENSP000003444684I2D: score=1 STRING: ENSP00000344468
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
    TIRAPP587533, ENSP000003764454I2D: score=1 STRING: ENSP00000376445
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    HRASP011123, ENSP000003098454I2D: score=4 STRING: ENSP00000309845
    MYOGP151733, ENSP000002416514I2D: score=1 STRING: ENSP00000241651
    SMAD4Q134853, ENSP000003415514I2D: score=1 STRING: ENSP00000341551
    CASKO149363, ENSP000003674084I2D: score=1 STRING: ENSP00000367408
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    MAPK3P273613I2D: score=1 
    YWHABP319463I2D: score=1 
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    ACTL6AO960192MINT-7947479
    ACTR1AP611632MINT-7947479
    ACTR2P611602MINT-7947479
    ADNPQ9H2P02MINT-7947479
    AHNAKQ096662MINT-7947479
    AKAP8O438232MINT-7947479
    ANAPC1Q9H1A42MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANLNQ9NQW62MINT-7947479
    ANXA11P509952MINT-7947479
    AP1B1Q105672MINT-7947479
    ARCN1P484442MINT-7947479
    ARGLU1Q9NWB62MINT-7947479
    ARHGEF1Q928882MINT-7947479
    ARHGEF2Q929742MINT-7947479
    ARID1AO144972MINT-7947479
    AURKBQ96GD42MINT-7947479
    BAZ1AQ9NRL22MINT-7947479
    BCAS2O759342MINT-7947479
    BCLAF1Q9NYF82MINT-7947479
    BIDP559572MINT-7947479
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRD8Q9H0E92MINT-7947479
    BTAF1O149812MINT-7947479
    BUB1O436832MINT-7947479
    BUB1BO605662MINT-7947479
    BUB3O436842MINT-7947479
    BZW1Q7L1Q62MINT-7947479
    C22orf28Q9Y3I02MINT-7947479
    C7orf13Q8NI282MINT-7947479
    CAPGP401212MINT-7947479
    CAPZA1P529072MINT-7947479
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCNB1P146352MINT-7947479
    CCT2P783712MINT-7947479
    CCT3P493682MINT-7947479
    CCT4P509912MINT-7947479
    CCT5P486432MINT-7947479
    CCT6AP402272MINT-7947479
    CCT7Q998322MINT-7947479
    CCT8P509902MINT-7947479
    CDC16Q130422MINT-7947479
    CDC20Q128342MINT-7947479
    CDC23Q9UJX22MINT-7947479
    CDC27P302602MINT-7947479
    CDC73Q6P1J92MINT-7947479
    CDK9P507502MINT-7947479
    CDKN2AIPQ9NXV62MINT-7947479
    CHD1LQ86WJ12MINT-7947479
    CHD8Q9HCK82MINT-7947479
    CHEK1O147572MINT-7947479
    CKAP5Q140082MINT-7947479
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPAP536212MINT-7947479
    COPB1P536182MINT-7947479
    COPB2P356062MINT-7947479
    COPG1Q9Y6782MINT-7947479
    COPG2Q9UBF22MINT-7947479
    COPS5Q929052MINT-7947479
    CPSF2Q9P2I02MINT-7947479
    CPSF3Q9UKF62MINT-7947479
    CPSF7Q8N6842MINT-7947479
    CSE1LP550602MINT-7947479
    CSTF3Q129962MINT-7947479
    CTNND1O607162MINT-7947479
    CUL1Q136162MINT-7947479
    CWC15Q9P0132MINT-7947479
    DCTN2Q135612MINT-7947479
    DDB1Q165312MINT-7947479
    DDX17Q928412MINT-7947479
    DDX19AQ9NUU72MINT-7947479
    DDX19BQ9UMR22MINT-7947479
    DDX39AO001482MINT-7947479
    DDX39BQ138382MINT-7947479
    DDX3XO005712MINT-7947479
    DDX41Q9UJV92MINT-7947479
    DDX42Q86XP32MINT-7947479
    DDX47Q9H0S42MINT-7947479
    DDX5P178442MINT-7947479
    DDX6P261962MINT-7947479
    DEPDC7Q96QD52MINT-7947479
    DFNA5O604432MINT-7947479
    DIAPH1O606102MINT-7947479
    DIDO1Q9BTC02MINT-7947479
    DMAP1Q9NPF52MINT-7947479
    DNAJA1P316892MINT-7947479
    DNM1LO004292MINT-7947479
    DNM2P505702MINT-7947479
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DRG1Q9Y2952MINT-7947479
    DSPP159242MINT-7947479
    DTYMKP239192MINT-7947479
    DYNC1H1Q142042MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    DYNC1LI2O432372MINT-7947479
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEF1A1P681042MINT-7947479
    EFTUD2Q150292MINT-7947479
    EHD1Q9H4M92MINT-7947479
    EHD4Q9H2232MINT-7947479
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S3P410912MINT-7947479
    EIF3BP558842MINT-7947479
    EIF3GO758212MINT-7947479
    EIF3IQ133472MINT-7947479
    EIF4A1P608422MINT-7947479
    EIF4A2Q142402MINT-7947479
    EIF4A3P389192MINT-7947479
    EIF4G2P783442MINT-7947479
    EIF5BO608412MINT-7947479
    ELAVL1Q157172MINT-7947479
    ELF2Q157232MINT-7947479
    ENAHQ8N8S72MINT-7947479
    ENSG00000266714Q96JP22MINT-7947479
    EPB41L3Q9Y2J22MINT-7947479
    EPPK1P581072MINT-7947479
    EPS8L2Q9H6S32MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    ETF1P624952MINT-7947479
    ETV6P412122MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC2Q96KP12MINT-7947479
    EXOC4Q96A652MINT-7947479
    EXOC5O004712MINT-7947479
    EXOC7Q9UPT52MINT-7947479
    EXOSC10Q017802MINT-7947479
    FAF1Q9UNN52MINT-7947479
    FAM129BQ96TA12MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FANCIQ9NVI12MINT-7947479
    FASNP493272MINT-7947479
    FEN1P397482MINT-7947479
    FERMT1Q9BQL62MINT-7947479
    FHOD1Q9Y6132MINT-7947479
    FUSP356372MINT-7947479
    GAPDHP044062MINT-7947479
    GATAD2AQ86YP42MINT-7947479
    GCN1L1Q926162MINT-7947479
    GEMIN4P576782MINT-7947479
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GTF2IP783472MINT-7947479
    GTF3C2Q8WUA42MINT-7947479
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GULP1Q9UBP92MINT-7947479
    HAUS7Q998712MINT-7947479
    HBS1LQ9Y4502MINT-7947479
    HDAC1Q135472MINT-7947479
    HDAC2Q927692MINT-7947479
    HDLBPQ003412MINT-7947479
    HELLSQ9NRZ92MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIP1RO751462MINT-7947479
    HIRAP541982MINT-7947479
    HLTFQ145272MINT-7947479
    HNRNPA2B1P226262MINT-7947479
    HNRNPCP079102MINT-7947479
    HNRNPFP525972MINT-7947479
    HNRNPH1P319432MINT-7947479
    HNRNPKP619782MINT-7947479
    HNRNPMP522722MINT-7947479
    HNRNPUQ008392MINT-7947479
    HSP90AA1P079002MINT-7947479
    HSP90AB1P082382MINT-7947479
    HSP90B1P146252MINT-7947479
    HSPA12AO433012MINT-7947479
    HSPA5P110212MINT-7947479
    HSPA6P170662MINT-7947479
    HSPA8P111422MINT-7947479
    HSPB1P047922MINT-7947479
    HSPD1P108092MINT-7947479
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF2Q129052MINT-7947479
    INTS1Q8N2012MINT-7947479
    INTS3Q68E012MINT-7947479
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO5O004102MINT-7947479
    IPO7O953732MINT-7947479
    IPO9Q96P702MINT-7947479
    IQGAP1P469402MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KDM1AO603412MINT-7947479
    KHDRBS1Q076662MINT-7947479
    KIF11P527322MINT-7947479
    KIF21AQ7Z4S62MINT-7947479
    KIF2CQ996612MINT-7947479
    KIF4AO952392MINT-7947479
    KPNA2P522922MINT-7947479
    KPNB1Q149742MINT-7947479
    LAS1LQ9Y4W22MINT-7947479
    LENG9Q96B702MINT-7947479
    LIMS1P480592MINT-7947479
    LMNAP025452MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC40Q9H9A62MINT-7947479
    LRWD1Q9UFC02MINT-7947479
    MAD1L1Q9Y6D92MINT-7947479
    MAGEE2Q8TD902MINT-7947479
    MAP2K4P459852MINT-7947479
    MAP2K7O147332MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MATR3P432432MINT-7947479
    MDN1Q9NU222MINT-7947479
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MED4Q9NPJ62MINT-7947479
    MELKQ146802MINT-7947479
    MPP2Q141682MINT-7947479
    MRE11AP499592MINT-7947479
    MSH2P432462MINT-7947479
    MSH6P527012MINT-7947479
    MTA2O947762MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MVPQ147642MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH9P355792MINT-7947479
    MYO15BQ96JP22MINT-7947479
    NACC1Q96RE72MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NBNO609342MINT-7947479
    NCAPD2Q150212MINT-7947479
    NCAPHQ150032MINT-7947479
    NCOR1O753762MINT-7947479
    NDC80O147772MINT-7947479
    NELFBQ8WX922MINT-7947479
    NIPBLQ6KC792MINT-7947479
    NONOQ152332MINT-7947479
    NPM1P067482MINT-7947479
    NRG1Q022972MINT-7947479
    NSFP464592MINT-7947479
    NSUN5Q96P112MINT-7947479
    NUDCQ9Y2662MINT-7947479
    NUDT21O438092MINT-7947479
    NUF2Q9BZD42MINT-7947479
    NUP107P577402MINT-7947479
    NUP155O756942MINT-7947479
    NUP93Q8N1F72MINT-7947479
    ORC2Q134162MINT-7947479
    ORC3Q9UBD52MINT-7947479
    OXSR1O957472MINT-7947479
    PAK4O960132MINT-7947479
    PARP1P098742MINT-7947479
    PARVAQ9NVD72MINT-7947479
    PARVBQ9HBI12MINT-7947479
    PCBP1Q153652MINT-7947479
    PCBP2Q153662MINT-7947479
    PCNTO956132MINT-7947479
    PDLIM7Q9NR122MINT-7947479
    PELOQ9BRX22MINT-7947479
    PFKMP082372MINT-7947479
    PFKPQ018132MINT-7947479
    PHGDHO431752MINT-7947479
    PICALMQ134922MINT-7947479
    PKN2Q165132MINT-7947479
    PLECQ151492MINT-7947479
    PLK1P533502MINT-7947479
    PLRG1O436602MINT-7947479
    PNNQ9H3072MINT-7947479
    POLD1P283402MINT-7947479
    POLR1CO151602MINT-7947479
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP1CAP621362MINT-7947479
    PPP2R1AP301532MINT-7947479
    PRCCQ927332MINT-7947479
    PRKDCP785272MINT-7947479
    PRPF19Q9UMS42MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF4BQ135232MINT-7947479
    PRPF6O949062MINT-7947479
    PRPF8Q6P2Q92MINT-7947479
    PSMC1P621912MINT-7947479
    PSMC2P359982MINT-7947479
    PSMC3P179802MINT-7947479
    PSMC4P436862MINT-7947479
    PSMC5P621952MINT-7947479
    PSMC6P623332MINT-7947479
    PSMD1Q994602MINT-7947479
    PSMD11O002312MINT-7947479
    PSMD12O002322MINT-7947479
    PSMD13Q9UNM62MINT-7947479
    PSMD2Q132002MINT-7947479
    PSMD3O432422MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP1P265992MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUM1Q146712MINT-7947479
    RACGAP1Q9H0H52MINT-7947479
    RAD18Q9NS912MINT-7947479
    RAD50Q928782MINT-7947479
    RALYQ9UKM92MINT-7947479
    RANBP2P497922MINT-7947479
    RANGAP1P460602MINT-7947479
    RAVER1Q8IY672MINT-7947479
    RBBP4Q090282MINT-7947479
    RBBP5Q152912MINT-7947479
    RBBP7Q165762MINT-7947479
    RBM17Q96I252MINT-7947479
    RBM39Q144982MINT-7947479
    RBM4Q9BWF32MINT-7947479
    RBM45Q8IUH32MINT-7947479
    RBM7Q9Y5802MINT-7947479
    RBMXP381592MINT-7947479
    RCOR1Q9UKL02MINT-7947479
    RFC2P352502MINT-7947479
    RFC3P409382MINT-7947479
    RFC4P352492MINT-7947479
    RFC5P409372MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RIF1Q5UIP02MINT-7947479
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    ROCK2O751162MINT-7947479
    RPL13P263732MINT-7947479
    RPL22P352682MINT-7947479
    RPL24P837312MINT-7947479
    RPL31P628992MINT-7947479
    RPLP0P053882MINT-7947479
    RPS13P622772MINT-7947479
    RPS6KA4O756762MINT-7947479
    RPS6KB2Q9UBS02MINT-7947479
    RUVBL1Q9Y2652MINT-7947479
    RUVBL2Q9Y2302MINT-7947479
    RXRBP287022MINT-7947479
    SART1O432902MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SCYL2Q6P3W72MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC24CP539922MINT-7947479
    SEH1LQ96EE32MINT-7947479
    SENP3Q9H4L42MINT-7947479
    SEPT9Q9UHD82MINT-7947479
    SETXQ7Z3332MINT-7947479
    SF3A1Q154592MINT-7947479
    SF3A2Q154282MINT-7947479
    SF3A3Q128742MINT-7947479
    SF3B1O755332MINT-7947479
    SF3B14Q9Y3B42MINT-7947479
    SF3B2Q134352MINT-7947479
    SF3B3Q153932MINT-7947479
    SFPQP232462MINT-7947479
    SHC1P293532MINT-7947479
    SHROOM3Q8TF722MINT-7947479
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA5O602642MINT-7947479
    SMARCAD1Q9H4L72MINT-7947479
    SMARCB1Q128242MINT-7947479
    SMARCC1Q929222MINT-7947479
    SMARCC2Q8TAQ22MINT-7947479
    SMARCD1Q96GM52MINT-7947479
    SMARCE1Q969G32MINT-7947479
    SMC1AQ146832MINT-7947479
    SMC2O953472MINT-7947479
    SMC3Q9UQE72MINT-7947479
    SMC4Q9NTJ32MINT-7947479
    SMCHD1A6NHR92MINT-7947479
    SMN1Q166372MINT-7947479
    SMN2Q166372MINT-7947479
    SNAPC4Q5SXM22MINT-7947479
    SNRNP200O756432MINT-7947479
    SNRNP40Q96DI72MINT-7947479
    SNRNP70P086212MINT-7947479
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPD1P623142MINT-7947479
    SNRPD3P623182MINT-7947479
    SNRPEP623042MINT-7947479
    SNW1Q135732MINT-7947479
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SOGA2Q9Y4B52MINT-7947479
    SPATA5Q8NB902MINT-7947479
    SPENQ96T582MINT-7947479
    SPTAN1Q138132MINT-7947479
    SPTBN1Q010822MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP54P610112MINT-7947479
    SRP68Q9UHB92MINT-7947479
    SRP72O760942MINT-7947479
    SRRM1Q8IYB32MINT-7947479
    SRSF1Q079552MINT-7947479
    SRSF4Q081702MINT-7947479
    SRSF7Q166292MINT-7947479
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUGT1Q9Y2Z02MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SYMPKQ927972MINT-7947479
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TANC2Q9HCD62MINT-7947479
    TARDBPQ131482MINT-7947479
    TBL1XR1Q9BZK72MINT-7947479
    TCP1P179872MINT-7947479
    THAP1Q9NVV92MINT-7947479
    THRAP3Q9Y2W12MINT-7947479
    TIAL1Q010852MINT-7947479
    TLN1Q9Y4902MINT-7947479
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TMPOP421662MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TNPO1Q929732MINT-7947479
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRAP1Q129312MINT-7947479
    TRIM21P194742MINT-7947479
    TRIM28Q132632MINT-7947479
    TRIP13Q156452MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TRUB1Q8WWH52MINT-7947479
    TSG101Q998162MINT-7947479
    TUBA1CQ9BQE32MINT-7947479
    TUBA4AP683662MINT-7947479
    TUBBP074372MINT-7947479
    TUBB4BP683712MINT-7947479
    TUBG1P232582MINT-7947479
    TUBGCP2Q9BSJ22MINT-7947479
    TUBGCP3Q96CW52MINT-7947479
    TUBGCP4Q9UGJ12MINT-7947479
    TWF1Q127922MINT-7947479
    U2AF1Q010812MINT-7947479
    U2AF2P263682MINT-7947479
    U2SURPO150422MINT-7947479
    UBA5Q9GZZ92MINT-7947479
    UBE2MP610812MINT-7947479
    UBE2NP610882MINT-7947479
    UBE2SQ167632MINT-7947479
    UBL4AP114412MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UCHL5Q9Y5K52MINT-7947479
    UMPSP111722MINT-7947479
    UNC45AQ9H3U12MINT-7947479
    UPF1Q929002MINT-7947479
    UPF2Q9HAU52MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP39Q53GS92MINT-7947479
    VIMP086702MINT-7947479
    VPS33AQ96AX12MINT-7947479
    VPS33BQ9H2672MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    WDR18Q9BV382MINT-7947479
    WDR33Q9C0J82MINT-7947479
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XRN2Q9H0D62MINT-7947479
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF638Q149662MINT-7947479
    UBR4ENSP000003644034STRING: ENSP00000364403
    SIRT7ENSP000003294664STRING: ENSP00000329466
    UBCENSP000003448184STRING: ENSP00000344818
    --C9JW422MINT-7947479
    --Q8WU302MINT-7947479
    --O957662MINT-7947479
    --Q130512MINT-7947479
    --Q7Z48 M2MINT-7947479
    --Q8TEF12MINT-7947479
    --ENSP000003230634MINT-7947479 STRING: ENSP00000323063
    --O602892MINT-7947479
    --Q9NVY62MINT-7947479
    --Q9NXK92MINT-7947479
    --Q86TR82MINT-7947479
    --Q7Z6R02MINT-7947479
    --Q133442MINT-7947479
    --ENSP000002779164MINT-7947479 STRING: ENSP00000277916
    --Q8N8M92MINT-7947479
    --Q9H6S72MINT-7947479
    --XP_2903452MINT-7947479
    --Q137272MINT-7947479
    --Q9UNL72MINT-7947479
    --O432092MINT-7947479
    --Q8N1C02MINT-7947479
    --A8K9D92MINT-7947479
    --Q8N2742MINT-7947479
    --Q8N5H62MINT-7947479
    --XP_0397022MINT-7947479
    --Q96PK22MINT-7947479
    --Q9HBD42MINT-7947479
    --Q9NXD32MINT-7947479
    --Q9Y2L02MINT-7947479
    --Q1424 E2MINT-7947479
    --Q9BTU22MINT-7947479
    About this table

    Gene Ontology (GO): 5/64 biological process terms (GO ID links to tree view) (see all 64):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ISS--
    GO:0001649osteoblast differentiation ISS--
    GO:0001656metanephros development ISS--
    GO:0001666response to hypoxia ISS--
    GO:0001889liver development ISS--


    NF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NF1
    10/35 Novoseek chemical compound relationships for NF1 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mantgtp 61.7 1 12667087 (1)
    gtp 58.7 34 8262937 (2), 12667087 (2), 8626511 (2), 8437847 (2) (see all 21)
    gdp 38.3 9 8437847 (2), 8658179 (1), 10555980 (1), 12667087 (1) (see all 5)
    guanosine 34.3 10 1496380 (1), 8658179 (1), 9589427 (1), 8302341 (1) (see all 8)
    rapamycin 24.3 7 19634141 (1), 20154675 (1), 16267007 (1), 18316617 (1)
    succinate 13.7 1 17102089 (1)
    retinoic acid 12.3 3 9619634 (2), 7576949 (1)
    phosphatidylinositol 11.4 2 18271718 (1), 10398103 (1)
    tyrosine 7.37 9 16914719 (3), 15467451 (1), 17348023 (1), 16467864 (1) (see all 7)
    nacl 5.61 2 8262937 (1), 7887472 (1)

    Search CenterWatch for drugs/clinical trials and news about NF1 

    Transcripts
    for NF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NF1 gene (3 alternative transcripts): 
    NM_000267.3  NM_001042492.2  NM_001128147.2  

    Unigene Cluster for NF1:

    Neurofibromin 1
    Hs.113577  [show with all ESTs]
    Unigene Representative Sequence: NM_001042492
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000487476(uc002hge.2) ENST00000358273(uc002hgg.3) ENST00000356175(uc002hgh.3 uc010cso.3)
    ENST00000431387(uc002hgf.2) ENST00000579081 ENST00000489712 ENST00000495910(uc010csn.2)
    ENST00000490416 ENST00000456735 ENST00000493220(uc002hgi.1) ENST00000466819
    ENST00000479614 ENST00000581113 ENST00000479536 ENST00000584328 ENST00000581790
    ENST00000471572 ENST00000582892

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): NF1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NF1
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate NF1 (see all 100):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: NF1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NF1 (see all 7)
    OriGene shRNA RFP: NF1
    OriGene siRNA: NF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NF1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NF1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NF1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NF1 (NM_002236)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NF1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NF1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NF1

    Additional cDNA sequence: 

    AB209336.1 AF055023.1 AF086346.1 AK026658.1 AK289936.1 AK301970.1 AK302063.1 BC144643.1 
    BX648717.1 D12625.1 D42072.1 M38106.1 M38107.1 M60496.1 M60915.1 M61213.1 
    M82814.1 M89914.1 

    24/26 DOTS entries (see all 26):

    DT.91768398  DT.100752198  DT.318104  DT.100752196  DT.97799977  DT.65285211  DT.100752195  DT.100664689 
    DT.91965143  DT.101975503  DT.95286460  DT.97791842  DT.100749793  DT.414179  DT.97771427  DT.120972573 
    DT.120973050  DT.414180  DT.100739552  DT.100749794  DT.75174633  DT.95286423  DT.97796593  DT.75120933 

    24/299 AceView cDNA sequences (see all 299):

    AL120050 AI244300 AA885527 BX118883 M82814 AI273054 D42072 BM013806 
    AA770360 BM683129 AW173779 T81221 CD244261 M60915 AA749036 CB243676 
    D12625 AA917437 M38107 BQ007653 BM504583 BP350476 AA744370 BU619171 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NF1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                  -                                         -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                  -                                                                                                         
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for NF1

    Expression
    for NF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular ValvesAtrioventricular Valve CellsEndocardium, Myocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NF1

    SOURCE GeneReport for Unigene cluster: Hs.113577
        SABiosciences Expression via Pathway-Focused PCR Arrays including NF1 (see all 6): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NF1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NF1

    Orthologs
    for NF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NF1 gene from 3/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NF11 neurofibromin 1 83.83(n)
    95.52(a)    		   396085  XM_415914.3  XP_415914.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufe06d032 Transcribed sequence with moderate similarity to protein more 75.63(n)    57060183 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nf11 , 3 cAMP-mediated signaling RAS GTPase activator3
    Neurofibromin 11    		 55(a)3
    57.97(n)1
    60.35(a)1    		   96F93
    431491  NM_170253.21  NP_733132.21 


    ENSEMBL Gene Tree for NF1 (if available)
    TreeFam Gene Tree for NF1 (if available) 

    Paralogs
    for NF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NF1 gene
    2 SIMAP similar genes for NF1 using alignment to 17 protein entries:     NF1_HUMAN (see all proteins):
    DKFZp686J1293    NF1 gene homologue

    NF1 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for NF1 (see all 9)
    PGOHUM00000239411 PGOHUM00000247700 PGOHUM00000258760 PGOHUM00000246630 PGOHUM00000246642


    Genomic Variants
    for NF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4086 NCBI SNPs in NF1 are shown (see all 4086)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1994747921,2
    		Cpathogenic27340508(+) ATGGCC/TGTCAA 4 P L mis10--------
    rs1378545561,2
    		Cpathogenic27439384(+) CTTCCA/C/GAGGCA 6 Q P R mis10--------
    rs1378545661,2
    		Cpathogenic27445967(+) CTTCCC/G/TTTGTG 6 P R L mis10--------
    rs1994747321,2
    		Cuntested27441998(+) CTGATC/G/TGGTTT 6 R G W mis10--------
    rs1994747401,2
    		C,untested27443021(+) CAAGCA/GTGGAA 4 M V mis10--------
    rs1427127511,2
    		C,F,untested27451579(+) AAATAC/G/TTGATC 6 L V syn1 mis12NA EU 5397
    rs178793861,2
    		C,F,--25630938(+) ACATAG/ACAAGA 3 -- us2k13Minor allele frequency- A:0.02NS NA 302
    rs96752071,2
    		C,F,--25631104(+) actgcA/Gcagag 3 -- us2k13Minor allele frequency- G:0.15WA 122
    rs1116379661,2
    		--25631152(+) GGTAAA/TATGTA 3 -- us2k12Minor allele frequency- T:0.03CSA WA 120
    rs178857171,2
    		C,--25631541(+) TGGATG/ATAATC 3 -- us2k11Minor allele frequency- A:0.01NS 150

    HapMap Linkage Disequilibrium report for NF1 (29421945 - 29671945 bp, first 250kb of NF1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for NF1
         4 CNVs: 72861 4999 72862 72860
         4 Indels: 40176 42474 61566 34310
    Human Gene Mutation Database (HGMD): NF1

    Locus Specific Mutation Databases (LSDB): NF1

    5/15 SABiosciences Cancer Mutation PCR Assays for NF1 (see all 15):
    Cosmic IdAA Change
    24576p.K1444E
    24444p.R816*
    24443p.R1362*
    24486p.R304*
    24495p.Q514fs*43
    1 SABiosciences Cancer Mutation PCR Array containing NF1:
    Tumor Suppressor Panel 384HT
    1 SABiosciences qBiomarker Copy Number PCR Array containing NF1:
    Oncogenes & Tumor Suppressor Genes 384HC
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NF1
    DNA2.0 Custom Variant and Variant Library Synthesis for NF1

    Disorders / Diseases
    for NF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NF1 for disorders           About GeneDecksing

    OMIM gene information: 613113   
    OMIM disorders: 162200  607785  162210  601321  193520  
    UniProtKB/Swiss-Prot: NF1_HUMAN, P21359
  • Defects in NF1 are the cause of neurofibromatosis type 1 (NF1) [MIM:162200]; also known as von Recklinghausen
    • syndrome. A disease characterized by patches of skin pigmentation (cafe-au-lait spots), Lisch nodules of the iris,
    tumors in the peripheral nervous system and fibromatous skin tumors. Individuals with the disorder have increased
    susceptibility to the development of benign and malignant tumors
  • Defects in NF1 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric
    • myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and
    2% of leukemia. Germline mutations of NF1 account for the association of JMML with type 1 neurofibromatosis (NF1)
  • Defects in NF1 are the cause of Watson syndrome (WS) [MIM:193520]. WS is characterized by the presence of
    • pulmonary stenosis, cafe-au-lait spots, and mental retardation. WS is considered as an atypical form of NF1
  • Defects in NF1 are a cause of familial spinal neurofibromatosis (FSNF) [MIM:162210]. Familial spinal NF is
    • considered to be an alternative form of neurofibromatosis, showing multiple spinal tumors
  • Defects in NF1 are a cause of neurofibromatosis-Noonan syndrome (NFNS) [MIM:601321]. NFNS is characterized by
    • manifestations of both NF1 and Noonan syndrome (NS). NS is a disorder characterized by dysmorphic facial features,
    short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis
  • Defects in NF1 may be a cause of colorectal cancer (CRC) [MIM:114500]

    • 20/110 diseases for NF1 (see all 110):    About MalaCards
    cafe-au-lait spots    neurofibromatosis    juvenile myelomonocytic leukemia    watson syndrome
    myelomonocytic leukemia    von hippel-lindau disease    li-fraumeni syndrome    malignant peripheral nerve sheath tumor
    familial spinal neurofibromatosis    melanoma, desmoplastic neurotrophic    multiple endocrine neoplasia    neurofibromatosis-noonan syndrome
    ring chromosome 22    multiple endocrine neoplasia type 2a    leukemia    optic pathway glioma
    dental enamel hypoplasia    ring chromosomes    retinol binding protein    tenosynovial giant cell tumor

    15 diseases from the University of Copenhagen DISEASES database for NF1:
    Neurofibromatosis     Neurofibroma     Malignant peripheral nerve sheath tumor     Malignant glioma
    Neurilemmoma     Optic nerve glioma     Genetic disorder     Juvenile myelomonocytic leukemia
    Noonan syndrome     Paraganglioma     Meningocele     Hemangioma
    Meningioma     Learning disability     Hydrocephalus

    10/92 Novoseek disease relationships for NF1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 1 97.1 238 7614817 (3), 9639526 (2), 9713168 (2), 10863097 (2) (see all 99)
    neurofibroma 91 80 15986446 (5), 11159187 (3), 10629698 (3), 17236191 (2) (see all 48)
    neurofibromatosis 89.5 57 8516298 (3), 1293176 (2), 8328449 (2), 9132486 (2) (see all 43)
    neurofibroma plexiform 83.5 7 19414372 (1), 16536802 (1), 17215493 (1), 17551851 (1) (see all 6)
    cafe-au-lait spots 83.1 6 10629698 (2), 8989459 (1), 15947937 (1), 8456833 (1) (see all 5)
    neurofibrosarcoma 81.9 8 8755348 (1), 7519874 (1), 8637706 (1), 10029430 (1) (see all 6)
    mpnst 81.3 26 19414372 (4), 12152785 (4), 11406645 (2), 10812008 (1) (see all 15)
    juvenile myelomonocytic leukemia 81 8 9639526 (2), 17353900 (2), 12393498 (1), 20015894 (1) (see all 8)
    malignant peripheral nerve sheath tumors 80.4 11 10534774 (1), 17348023 (1), 19414372 (1), 9354454 (1) (see all 10)
    watson syndrome 78.1 1 1770531 (1)

    Genatlas disease: NF1
    neurofibromatosis 1 (von Recklinghausen disease),characterized by cafe au lait spots,axillary freckling,Lisch nodules
    of the iris,multiple neurofibromas,tibial pseudarthrosis and a predisposition to certain benign and malignant tumors
    of the central and peripheral nervous system,with a variable expression even among relatives with the same mutation
    and apparently an earlier onset or a more severe form associated with deletions,including neurofibrosarcoma (see
    TSG17C),Watson disease (cafe au lait spots with pulmonic stenosis)

    GeneTests: NF1
    Neurofibromatosis 1

    Genetic Association Database (GAD): NF1
    Human Genome Epidemiology (HuGE) Navigator: NF1 (38 documents)

    Export disorders for NF1 gene to outside databases

    Publications
    for NF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NF1 gene, integrated from 9 sources (see all 745):
    (articles sorted by number of sources associating them with NF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. NF1 gene analysis based on DHPLC. (PubMed id 12552569)1, 2, 4, 9 De Luca A.... Dallapiccola B. (2003)
    2. NF1 gene mutations represent the major molecular event underlying neurofibromatosis-Noonan syndrome. (PubMed id 16380919)1, 2, 4 De Luca A.... Dallapiccola B. (2005)
    3. Novel and recurrent mutations in the NF1 gene in Italian patients with neurofibromatosis type 1. (PubMed id 15146469)1, 2, 4 De Luca A.... Dallapiccola B. (2004)
    4. Exon 10b of the NF1 gene represents a mutational hotspot and harbors a recurrent missense mutation Y489C associated with aberrant splicing. (PubMed id 11258625)1, 2, 4 Messiaen L.M.... Wallace M.R. (1999)
    5. Genomic organization of the neurofibromatosis 1 gene (NF1). (PubMed id 7774960)1, 2, 9 Li Y.... Viskochil D. (1995)
    6. Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases. (PubMed id 13679444)1, 4, 9 Lasota J....Miettinen M. (2003)
    7. Evidence for the presence of two amino-terminal isoforms of neurofibromin, a gene product responsible for neurofibromatosis type 1. (PubMed id 7570581)1, 2, 9 Suzuki H.... Shibahara S. (1995)
    8. Somatic mutations in the neurofibromatosis 1 gene in human tumors. (PubMed id 1568247)1, 2, 9 Li Y.... Cawthon R.M. (1992)
    9. NF1 mutations and clinical spectrum in patients with spinal neurofibromas. (PubMed id 12746402)1, 2, 9 Kluwe L.... Mautner V.F. (2003)
    10. Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1 (NF1). (PubMed id 9668168)1, 2, 9 Klose A....Nuernberg P. (1998)

    External Searches for NF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4763 HGNC: 7765 AceView: NF1 Ensembl:ENSG00000196712 euGenes: HUgn4763
    ECgene: NF1 Kegg: 4763 H-InvDB: NF1

    Other Databases showing NF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NF1 Genetics and Cytogenetics in Oncology and Haematology
    NF1 Genetic Mutation Analysis Consortiumhttp://www.upmc.edu/Neurofibro/NNFFconsortium.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NF1
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nf1/

    Intellectual Property
    for NF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NF1 gene:
    Search GeneIP for patents involving NF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NF1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NF1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NF1   OriGene shRNA RFP for NF1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NF1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NF1  
     OriGene Protein Over-expression Lysate for NF1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NF1   OriGene 3'-UTR Clone for NF1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NF1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NF1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NF1   OriGene Custom Protein Services for NF1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NF1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NF1
     GenScript Custom Purified and Recombinant Proteins Services for NF1 GenScript cDNA clones with any tag delivered in your preferred vector for NF1
     GenScript Custom Assay Services for NF1 GenScript Superior Antibodies for NF1
     GenScript Custom overexpressing Cell Line Services for NF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NF1 promoter
     Search Chromatin IP Primers for NF1
     RT2 qPCR Primer Assay in human, mouse, rat NF1
     GNC Network for NF1
     SABiosciences PCR Arrays including human, mouse, rat NF1
     Search Tocris compounds for NF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NF1 antibodies
     NF1 proteins
     Search for Antibodies for NF1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NF1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NF1
     SwitchGear 3'UTR luciferase reporter plasmids for NF1
     SwitchGear Promoter luciferase reporter plasmids for NF1
     ThermoFisher Antibody for NF1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NF1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NF1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4