NEUROG3 Gene

Aliases
for NEUROG3 gene

Previous GC identifers: GC10M070143 GC10M070418 GC10M071224 GC10M070676 GC10M071001 GC10M065321

Summaries
for NEUROG3 gene

Genomic Views
for NEUROG3 gene

RefSeq DNA sequence:

NC_000010.10  NC_018921.1  NT_030059.13  

SwitchGear Promoter luciferase reporter plasmid: NEUROG3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROG3

NEUROG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M071331:  view genomic region     (about GC identifiers)

Proteins
for NEUROG3 gene

Explore the universe of human proteins at neXtProt for NEUROG3: NX_Q9Y4Z2

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NEUROG3 OriGene Protein Over-expression Lysate: NEUROG3 OriGene Custom Protein Services for NEUROG3
	GenScript Custom Purified and Recombinant Proteins Services for NEUROG3
	Novus Biologicals NEUROG3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NEUROG3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROG3
	R&D Systems Antibodies for NEUROG3 (Neurogenin-3)
	OriGene Antibodies (see all 3): NEUROG3 OriGene Custom Antibody Services for NEUROG3
	GenScript Superior Antibodies for NEUROG3
	Novus Biologicals NEUROG3 Antibodies
	Search for Antibodies for NEUROG3 at Abcam
	Uscn Antibodies for NEUROG3
	ThermoFisher Antibodies for NEUROG3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NEUROG3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NEUROG3

Protein Domains /
Families
for NEUROG3 gene

ProtoNet protein and cluster: Q9Y4Z2

Function
for NEUROG3 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROG3
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NEUROG3
		SwitchGear 3'UTR luciferase reporter plasmid: NEUROG3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROG3 (see all 7) OriGene shRNA RFP: NEUROG3 OriGene siRNA: NEUROG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROG3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NEUROG3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NEUROG3 (NM_020999)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NEUROG3
		Search LifeMap BioReagents cell lines for NEUROG3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 9 alleles) (MGI details for Neurog3)

Pathways & Interactions
for NEUROG3 gene

	Super-pathway	contained gene-specific pathways
1	Regulation of beta-cell development	Regulation of beta-cell development 1.00 Maturity onset diabetes of the young 0.56
2	Transcription factors in neurogenesis	Transcription factors in neurogenesis 1.00
3	Notch-mediated HES/HEY network	Notch-mediated HES/HEY network 1.00
4	HNF6-dependent synthesis of NEUROG3 protein during morphogenesis	HNF6-dependent synthesis of NEUROG3 protein during morphogenesis 1.00
5	Axon guidance	Developmental Biology 0.69

1 EMD Millipore Pathway for NEUROG3

Transcription factors in neurogenesis

1 BioSystems Pathway for NEUROG3

Notch-mediated HES/HEY network

4        Reactome Pathways for NEUROG3

	Developmental Biology
	Regulation of beta-cell development
	HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

1         Kegg Pathway  (Kegg details for NEUROG3)

Maturity onset diabetes of the young

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

Drugs & Compounds
for NEUROG3 gene

Transcripts
for NEUROG3 gene

Expression
for NEUROG3 gene

NEUROG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	PancreasDorsal Pancreatic BudEndocrine Progenitor Cells			Pancreas
	PancreasVentral Pancreatic BudEndocrine Progenitor Cells			Pancreas
	PancreasVentral Pancreatic BudPancreatic Progenitor Cells			Pancreas
	TestisSeminiferous TubulesSpermatogonium Type A			Germ Cells, Male Gametocytes
	PancreasDorsal Pancreatic BudDuct Progenitor Cells			Pancreas
	PancreasDorsal Pancreatic BudExocrine Progenitor Cells			Pancreas
	PancreasIslets of LangerhansMature Beta Cells			Pancreas
	PancreasVentral Pancreatic BudDuct Progenitor Cells			Pancreas
	PancreasVentral Pancreatic BudExocrine Progenitor Cells			Pancreas
	PancreasDorsal Pancreatic BudBipotent Endocrine/Duct Progenitor Cells			Pancreas
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 8 LifeMap Cells
	Name			Category
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
	Posterior foregut-like cells (A scalable, suspensi...)
	Indolactam V-induced cells (Derivation of pancre...)
	Pancreatic endoderm-like cells (Generation of beta c...)
	Endocrine progenitors (Generation of pancre...)
	Posterior foregut (Generation of pancre...)
	Pancreatic progenitor-like cells (Derivation of beta c...)
	beta-like cells (Serum-free protocol ...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEUROG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG3

Orthologs
for NEUROG3 gene

Paralogs
for NEUROG3 gene

Paralogs for NEUROG3 gene

FERD3L²  NEUROD2²  NEUROD1²  NEUROD6²  NEUROG2²  ATOH1²  BHLHA15²  PTF1A²  

ATOH7²  NEUROG1²  NEUROD4²  

4 SIMAP similar genes for NEUROG3 using alignment to 2 protein entries:     NGN3_HUMAN (see all proteins):

NEUROG1    BHLHA15    NEUROG2    TAL2

NEUROG3 for paralogs           About GeneDecksing

Genomic Variants
for NEUROG3 gene

10/71 NCBI SNPs in NEUROG3 are shown (see all 71)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1219178371,2	C	pathogenic	65322405(-)	CCCTGA/CGCGGT	2	S R	mis1		0	--	--	--	--
rs1219178381,2	C	pathogenic	65322446(-)	CGAGCG/TCAATC	2	R L	mis1		0	--	--	--	--
rs759607191,2	C,F,	--	65321302(+)	GCCATA/GTAATT	1	--	ds5001		1		WA	118
rs1163809581,2	C,F,	--	65321846(+)	ATGCCC/TACTTC	1	--	ut31		1		WA	118
rs1123442071,2	C,F	--	65322668(+)	AGGACC/AGCTCC	2	/R /L	mis1		2		CSA NA	3712
rs785875621,2	F,	--	65323366(+)	GAGAAG/AAGCCT	1	--	us2k1		1		WA	118
rs780695281,2	F,	--	65323401(+)	CAGACG/AGCTTT	1	--	us2k1		1		WA	118
rs127848761,2	C,F	--	65323863(+)	AGCCTA/CCTACA	1	--	us2k1		3		NA	6
rs798068721,2	F,	--	65324266(+)	AAGGCG/TCTGGG	1	--	us2k1		1		WA	118
rs727989291,2	C,	--	65324526(+)	AAGGGG/ACTCTG	1	--	us2k1		1		NA	2

HapMap Linkage Disequilibrium report for NEUROG3 (71331454 - 71333210 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NEUROG3
     1 CNV: 6879
Human Gene Mutation Database (HGMD): NEUROG3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEUROG3

DNA2.0 Custom Variant and Variant Library Synthesis for NEUROG3

Disorders / Diseases
for NEUROG3 gene

17 diseases for NEUROG3

3 Novoseek disease relationships for NEUROG3 gene    About this table

Publications
for NEUROG3 gene

PubMed articles for NEUROG3 gene, integrated from 9 sources (see all 88): (articles sorted by number of sources associating them with NEUROG3)

Utopia: connect your pdf to the dynamic world of online information

1. Mutant neurogenin-3 in congenital malabsorptive diarrhea. (PubMed id 16855267)^{1, 2, 9} Wang J.... Martin M.G. (2006)
2. Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population. (PubMed id 15277395)^{1, 4, 9} Jackson A.E....Hitman G.A. (2004)
3. Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects. (PubMed id 11270683)^{1, 4, 9} Okada T....Kadowaki T. (2001)
4. Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population. (PubMed id 11206403)^{1, 4, 9} Jensen J.N....Pedersen O. (2001)
5. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. (PubMed id 10677506)^{1, 3} Gradwohl G....Guillemot F. (2000)
6. neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. (PubMed id 9000438)^{1, 3} Sommer L....Anderson D.J. (1996)
7. NEUROG3 variants and type 2 diabetes in Italians. (PubMed id 17146417)^{1, 9} Milord E. and Gragnoli C. (2006)
8. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. (PubMed id 12403815)^{1, 9} Heremans Y....Heimberg H. (2002)
9. Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects. (PubMed id 11246894)^{1, 9} del Bosque-Plata L....Bell G.I. (2001)
10. Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells. (PubMed id 19307926)^{1, 9} Lejonklou M.H....Skogseid B. (2009)

External Searches for NEUROG3 gene

Genome Databases showing NEUROG3 gene

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Specialized Databases showing NEUROG3 gene

Products
for NEUROG3 gene