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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEUROG3 Gene

protein-coding   GIFtS: 59
GCID: GC10M071331

Neurogenin 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurogenin 31 2     NGN33 5
Class A Basic Helix-Loop-Helix Protein 72 3     Atoh52
Protein Atonal Homolog 52 3     Math4B2
NGN-32 3     neurogenin-32
bHLHa72 3     ngn32
ATOH53 5     BHLHA73

External Ids:    HGNC: 138061   Entrez Gene: 506742   Ensembl: ENSG000001228597   OMIM: 6048825   UniProtKB: Q9Y4Z23   

Export aliases for NEUROG3 gene to outside databases

Previous GC identifers: GC10M070143 GC10M070418 GC10M071224 GC10M070676 GC10M071001 GC10M065321


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEUROG3 Gene:
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis.
The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of
congenital malabsorptive diarrhea 4 (DIAR4).(provided by RefSeq, May 2010)

GeneCards Summary for NEUROG3 Gene: 
NEUROG3 (neurogenin 3) is a protein-coding gene. Diseases associated with NEUROG3 include diarrhea 4, malabsorptive, congenital, and pancreatic endocrine tumor, and among its related super-pathways are Regulation of beta-cell development and Axon guidance. GO annotations related to this gene include double-stranded DNA binding and transcription coactivator activity. An important paralog of this gene is NEUROD2.

UniProtKB/Swiss-Prot: NGN3_HUMAN, Q9Y4Z2
Function: Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of
NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic
endocrine cell types (By similarity)

Gene Wiki entry for NEUROG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEUROG3 gene promoter:
         E2F-4   E2F-3a   E2F-5   GATA-3   POU6F1 (c2)   E2F-2   Max   E2F   E2F-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEUROG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21.3

NEUROG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROG3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M071331:  view genomic region     (about GC identifiers)

Start:
71,331,454 bp from pter      End:
71,333,210 bp from pter
Size:
1,757 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NGN3_HUMAN, Q9Y4Z2 (See protein sequence)
Recommended Name: Neurogenin-3  
Size: 214 amino acids; 23077 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5VVI0 Q6DJX6 Q9BY24

Explore the universe of human proteins at neXtProt for NEUROG3: NX_Q9Y4Z2

Explore proteomics data for NEUROG3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4Z2

  • NEUROG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEUROG3 Protein Expression
    REFSEQ proteins: NP_066279.2  
    ENSEMBL proteins: 
     ENSP00000242462  
    Reactome Protein details: Q9Y4Z2
    Human Recombinant Protein Products for NEUROG3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    GenScript Custom Purified and Recombinant Proteins Services for NEUROG3
    Novus Biologicals NEUROG3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEUROG3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    NEUROG3 for ontologies           About GeneDecksing



    NEUROG3 Antibody Products: 
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    ThermoFisher Antibodies for NEUROG3
    LSBio Antibodies in human, mouse, rat for NEUROG3 

    Assay Products for NEUROG3: 
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    Cloud-Clone Corp. ELISAs for NEUROG3 
    Cloud-Clone Corp. CLIAs for NEUROG3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4Z2

    ProtoNet protein and cluster: Q9Y4Z2

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NGN3_HUMAN, Q9Y4Z2
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    NEUROG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NGN3_HUMAN, Q9Y4Z2
    Function: Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of
    NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic
    endocrine cell types (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003713transcription coactivator activity ISS--
    GO:0046983protein dimerization activity IEA--
         
    NEUROG3 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Neurog3):
     adipose tissue  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  mortality/aging  no phenotypic analysis  normal  renal/urinary system 

    NEUROG3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neurog3tm1Fgu for NEUROG3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEUROG3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEUROG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEUROG3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEUROG3 

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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of NEUROG3

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of NEUROG3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEUROG3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.56
    Maturity onset diabetes of the young0.56
    2Axon guidance
    Developmental Biology0.69
    3Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    4Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    5Notch-mediated HES/HEY network
    Notch-mediated HES/HEY network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NEUROG3
        Transcription factors in neurogenesis


    1 BioSystems Pathway for NEUROG3
        Notch-mediated HES/HEY network

    3        Reactome Pathways for NEUROG3
        Developmental Biology
    Regulation of beta-cell development
    Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells


    1         Kegg Pathway  (Kegg details for NEUROG3):
        Maturity onset diabetes of the young


    NEUROG3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEUROG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for NEUROG3 (ENSP000002424624) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HES6ENSP000002729374STRING: ENSP00000272937
    INSM1ENSP000003126314STRING: ENSP00000312631
    NEUROD1ENSP000002951084STRING: ENSP00000295108
    NKX2-2ENSP000003663474STRING: ENSP00000366347
    ONECUT1ENSP000003026304STRING: ENSP00000302630
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development ----
    GO:0007399nervous system development TAS9000438
    GO:0007417central nervous system development TAS9000438
    GO:0007422peripheral nervous system development TAS9000438

    NEUROG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEUROG3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEUROG3 (NGN3)

    1 Novoseek inferred chemical compound relationship for NEUROG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 26.4 7 15793239 (3), 15277395 (2), 16504534 (1), 17512083 (1)

    Search CenterWatch for drugs/clinical trials and news about NEUROG3 / NGN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEUROG3 gene: 
    NM_020999.3  

    Unigene Cluster for NEUROG3:

    Neurogenin 3
    Hs.532682
    Unigene Representative Sequence: NM_020999
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000242462(uc001jpp.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NEUROG3
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG3

    Additional mRNA sequence: 

    AK313952.1 BC069098.1 BC074938.2 BC074939.2 BC117488.1 BC126468.1 GQ904714.1 

    1 DOTS entry:

    DT.91948879 

    4 AceView cDNA sequences:

    BC074939 BC069098 BC074938 NM_020999 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEUROG3 expression in normal human tissues (normalized intensities)      NEUROG3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEUROG3 Expression
    About this image


    NEUROG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 21 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Beta-like cells ( Serum-free protocol to generate islet clusters from embryonic...
             visceral organ/gut/foregut-midgut junction   
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
             Telencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Gonad
             Spermatogonium Type A Seminiferous Tubules

    See NEUROG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEUROG3

    SOURCE GeneReport for Unigene cluster: Hs.532682
        SABiosciences Custom PCR Arrays for NEUROG3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEUROG3 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurog31 , 5 neurogenin 31, 5 78.72(n)1
    76.53(a)1
      10 (32.35 cM)5
    119251  NM_009719.61  NP_033849.31 
     621330905 
    chicken
    (Gallus gallus)
    Aves LOC1008581741 neurogenin-3-like 70.37(n)
    68.38(a)
      100858174  XM_003641471.1  XP_003641519.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurog36
    neurogenin 3
    36(a)
    1 ↔ 1
    13(25985171-25986281)
    fruit fly
    (Drosophila melanogaster)
    Insecta tap6
    target of Poxn
    14(a)
    1 → many
    3L(17352782-17354911)
    worm
    (Caenorhabditis elegans)
    Secernentea ngn-16
    cnd-16
    Neurogenic differentiation factor 1
    24(a)
    23(a)
    1 ↔ many
    possible ortholog
    IV(2626132-2628230)
    III(5240593-5242108)


    ENSEMBL Gene Tree for NEUROG3 (if available)
    TreeFam Gene Tree for NEUROG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEUROG3 gene
    NEUROD22  NEUROG22  NEUROD12  NEUROD62  ATOH12  BHLHA152  ATOH72  NEUROG12  
    NEUROD42  
    4 SIMAP similar genes for NEUROG3 using alignment to 2 protein entries:     NGN3_HUMAN (see all proteins):
    NEUROG1    BHLHA15    NEUROG2    TAL2

    NEUROG3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 SNPs in NEUROG3 are shown (see all 87)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0290034
    Diarrhea 4, malabsorptive, congenital (DIAR4)4--see VAR_0290032 R L mis40--------
    VAR_0290044
    Diarrhea 4, malabsorptive, congenital (DIAR4)4--see VAR_0290042 R S mis40--------
    rs1219178371,2
    Cpathogenic171705878(-) CCCTGA/CGCGGT 2 S R mis10--------
    rs1219178381,2
    Cpathogenic171705919(-) CGAGCG/TCAATC 2 R L mis10--------
    rs759607191,2
    C,F--71704774(+) GCCATA/GTAATT 1 -- ds50011Minor allele frequency- G:0.08WA 118
    rs109988611,2
    C,F,H--71704965(+) CGCCCC/TGGGAG 1 -- ds5001 ese316Minor allele frequency- T:0.07NS EA NA WA 2338
    rs108234081,2
    C,F,A,H--71705042(+) TGAGGC/TGCCCT 1 -- ds5001 ese33Minor allele frequency- T:0.06WA NA EA 358
    rs1931675551,2
    --71705154(+) TGGAGA/GAGGGG 1 -- ds50010--------
    rs1163809581,2
    C,F--71705319(+) ATGCCC/TACTTC 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs1512146291,2
    --71705359(+) TGGCGC/GGGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NEUROG3 (71331454 - 71333210 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NEUROG3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv32737CNV Gain+Loss17666407


    Human Gene Mutation Database (HGMD): NEUROG3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604882   
    OMIM disorders: 610370  
    UniProtKB/Swiss-Prot: NGN3_HUMAN, Q9Y4Z2
  • Diarrhea 4, malabsorptive, congenital (DIAR4) [MIM:610370]: A disease characterized by severe,
    life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine
    cells. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 15 diseases for NEUROG3:    About MalaCards
    diarrhea 4, malabsorptive, congenital    pancreatic endocrine tumor    diarrhea    maturity-onset diabetes of the young
    glucose intolerance    multiple endocrine neoplasia    duodenitis    insulinoma
    coronary heart disease    hyperglycemia    diabetes mellitus    retinitis
    pancreatitis    adenoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NEUROG3:
    Diabetes mellitus

    NEUROG3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for NEUROG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 34.6 10 11270683 (3), 11246894 (2), 11206403 (1), 11344245 (1)
    hyperinsulinemia 16.7 2 15793239 (1)
    tumors 5.55 9 19307926 (3)

    Genetic Association Database (GAD): NEUROG3
    Human Genome Epidemiology (HuGE) Navigator: NEUROG3 (11 documents)

    Export disorders for NEUROG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEUROG3 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with NEUROG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutant neurogenin-3 in congenital malabsorptive diarrhea. (PubMed id 16855267)1, 2, 9 Wang J.... Martin M.G. (2006)
    2. NEUROG3 variants and type 2 diabetes in Italians. (PubMed id 17146417)1, 4, 9 Milord E. and Gragnoli C. (2006)
    3. Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population. (PubMed id 15277395)1, 4, 9 Jackson A.E....Hitman G.A. (2004)
    4. Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes. (PubMed id 18072012)1, 4, 9 Li J....Schwarz P.E. (2008)
    5. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. (PubMed id 18093211)1, 4, 9 Louet J.F....Mauvais-Jarvis F. (2007)
    6. Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects. (PubMed id 11270683)1, 4, 9 Okada T....Kadowaki T. (2001)
    7. Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population. (PubMed id 11206403)1, 4, 9 Jensen J.N....Pedersen O. (2001)
    8. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (2009)
    9. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. (PubMed id 18210030)1, 4 Cauchi S....Froguel P. (2008)
    10. Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. (PubMed id 18461161)1, 4 Cauchi S....Froguel P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50674 HGNC: 13806 AceView: NEUROG3 Ensembl:ENSG00000122859 euGenes: HUgn50674
    ECgene: NEUROG3 Kegg: 50674 H-InvDB: NEUROG3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEUROG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEUROG3 gene:
    Search GeneIP for patents involving NEUROG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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