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Aliases for NEUROG3 Gene

Aliases for NEUROG3 Gene

  • Neurogenin 3 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 7 3 4
  • Protein Atonal Homolog 5 3 4
  • BHLHa7 3 4
  • Atoh5 3 4
  • NGN-3 3 4
  • Ngn3 3 4
  • Neurogenin-3 3
  • Math4B 3

External Ids for NEUROG3 Gene

Previous GeneCards Identifiers for NEUROG3 Gene

  • GC10M070143
  • GC10M070418
  • GC10M071224
  • GC10M070676
  • GC10M071001
  • GC10M071331
  • GC10M065321

Summaries for NEUROG3 Gene

Entrez Gene Summary for NEUROG3 Gene

  • The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]

GeneCards Summary for NEUROG3 Gene

NEUROG3 (Neurogenin 3) is a Protein Coding gene. Diseases associated with NEUROG3 include Diarrhea 4, Malabsorptive, Congenital and Congenital Diarrhea. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Regulation of beta-cell development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NEUROG1.

UniProtKB/Swiss-Prot for NEUROG3 Gene

  • Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).

Gene Wiki entry for NEUROG3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROG3 Gene

Genomics for NEUROG3 Gene

Regulatory Elements for NEUROG3 Gene

Enhancers for NEUROG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G069490 1.1 ENCODE dbSUPER 11.2 +78.0 77957 9.1 PKNOX1 RAD21 ZNF23 GATA2 SCRT2 ZSCAN5C ZMIZ1 FOS EGR2 SMARCA5 TSPAN15 NEUROG3 LOC101929021 C10orf35 TMEM256P1 GC10M069447
GH10G069507 1.1 dbSUPER 11.2 +67.0 66962 0.5 HDGF CREB3L1 FEZF1 ZNF2 KLF13 REST ZNF592 ZNF610 SMARCA4 GLIS1 NEUROG3 LOC101929021 C10orf35 TMEM256P1 GC10M069447
GH10G069637 0.7 ENCODE 11.3 -63.6 -63626 0.2 CTCF MAZ ZNF654 RBBP5 RAD21 ZNF560 ZNF335 POLR2A ZNF692 PATZ1 NEUROG3 LOC101929021 COL13A1 LOC102723350 C10orf35 LOC105378346
GH10G069501 0.7 dbSUPER 11.2 +70.7 70680 1.8 RBBP5 ZNF398 ZBTB8A OSR2 ZNF664 ZNF589 ZFHX2 PATZ1 ZNF24 PRDM10 TSPAN15 LOC101929021 NEUROG3 C10orf35 TMEM256P1 GC10M069447
GH10G069538 0.4 FANTOM5 12.2 +34.8 34797 0.2 POLR2A HK1 NEUROG3 LOC101929021 C10orf35 LOC105378345 TMEM256P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEUROG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEUROG3 Gene

Chromosome:
10
Start:
69,571,698 bp from pter
End:
69,573,454 bp from pter
Size:
1,757 bases
Orientation:
Minus strand

Genomic View for NEUROG3 Gene

Genes around NEUROG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROG3 Gene

Proteins for NEUROG3 Gene

  • Protein details for NEUROG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4Z2-NGN3_HUMAN
    Recommended name:
    Neurogenin-3
    Protein Accession:
    Q9Y4Z2
    Secondary Accessions:
    • Q5VVI0
    • Q6DJX6
    • Q9BY24

    Protein attributes for NEUROG3 Gene

    Size:
    214 amino acids
    Molecular mass:
    23077 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ATOH8.

neXtProt entry for NEUROG3 Gene

Post-translational modifications for NEUROG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NEUROG3 (Neurogenin-3)
  • Cloud-Clone Corp. Antibodies for NEUROG3

No data available for DME Specific Peptides for NEUROG3 Gene

Domains & Families for NEUROG3 Gene

Gene Families for NEUROG3 Gene

Protein Domains for NEUROG3 Gene

Suggested Antigen Peptide Sequences for NEUROG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEUROG3: view

No data available for UniProtKB/Swiss-Prot for NEUROG3 Gene

Function for NEUROG3 Gene

Molecular function for NEUROG3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 14576336
GO:0001047 core promoter binding IEA,ISS --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 14576336
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NEUROG3: view
genes like me logo Genes that share phenotypes with NEUROG3: view

Human Phenotype Ontology for NEUROG3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NEUROG3 Gene

MGI Knock Outs for NEUROG3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NEUROG3 Gene

Localization for NEUROG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEUROG3 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NEUROG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 20807725
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NEUROG3: view

Pathways & Interactions for NEUROG3 Gene

genes like me logo Genes that share pathways with NEUROG3: view

Gene Ontology (GO) - Biological Process for NEUROG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14576336
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with NEUROG3: view

No data available for SIGNOR curated interactions for NEUROG3 Gene

Drugs & Compounds for NEUROG3 Gene

(1) Drugs for NEUROG3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NEUROG3: view

Transcripts for NEUROG3 Gene

mRNA/cDNA for NEUROG3 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROG3 Gene

Neurogenin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG3 Gene

No ASD Table

Relevant External Links for NEUROG3 Gene

GeneLoc Exon Structure for
NEUROG3
ECgene alternative splicing isoforms for
NEUROG3

Expression for NEUROG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEUROG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROG3 Gene

This gene is overexpressed in Brain - Hippocampus (x20.4), Small Intestine - Terminal Ileum (x8.4), and Colon - Transverse (x6.8).

NURSA nuclear receptor signaling pathways regulating expression of NEUROG3 Gene:

NEUROG3

SOURCE GeneReport for Unigene cluster for NEUROG3 Gene:

Hs.532682

Evidence on tissue expression from TISSUES for NEUROG3 Gene

  • Intestine(4.4)
  • Pancreas(3.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NEUROG3 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • digestive
  • nervous
  • urinary
Organs:
Head and neck:
  • brain
  • head
Thorax:
  • esophagus
Abdomen:
  • intestine
  • kidney
  • large intestine
  • small intestine
  • stomach
genes like me logo Genes that share expression patterns with NEUROG3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NEUROG3 Gene

Orthologs for NEUROG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROG3 34 35
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia NEUROG3 34 35
  • 85.36 (n)
dog
(Canis familiaris)
Mammalia NEUROG3 34 35
  • 85.2 (n)
rat
(Rattus norvegicus)
Mammalia Neurog3 34
  • 79.97 (n)
mouse
(Mus musculus)
Mammalia Neurog3 34 16 35
  • 78.72 (n)
oppossum
(Monodelphis domestica)
Mammalia NEUROG3 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurog3 34
  • 58.42 (n)
zebrafish
(Danio rerio)
Actinopterygii neurog3 35
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tap 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for NEUROG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEUROG3 Gene

ENSEMBL:
Gene Tree for NEUROG3 (if available)
TreeFam:
Gene Tree for NEUROG3 (if available)

Paralogs for NEUROG3 Gene

(4) SIMAP similar genes for NEUROG3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEUROG3: view

Variants for NEUROG3 Gene

Sequence variations from dbSNP and Humsavar for NEUROG3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs121917837 Pathogenic, Diarrhea 4, malabsorptive, congenital (DIAR4) [MIM:610370] 69,572,725(-) CCCTG(A/C)GCGGT upstream-variant-2KB, reference, missense
rs121917838 Pathogenic, Diarrhea 4, malabsorptive, congenital (DIAR4) [MIM:610370] 69,572,766(-) CGAGC(G/T)CAATC upstream-variant-2KB, reference, missense
rs4536103 Likely benign 69,572,448(+) CGGAA(A/G)AGGTG upstream-variant-2KB, reference, missense
rs41277236 Benign 69,572,545(+) GTCCC(C/T)GGGGG upstream-variant-2KB, reference, missense
rs1001348641 -- 69,571,444(+) GCCCT(C/T)CTCTC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NEUROG3 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
nsv950975 CNV deletion 24416366

Variation tolerance for NEUROG3 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.95; 87.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEUROG3 Gene

Human Gene Mutation Database (HGMD)
NEUROG3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEUROG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEUROG3 Gene

Disorders for NEUROG3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NEUROG3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diarrhea 4, malabsorptive, congenital
  • congenital malabsorptive diarrhea 4
congenital diarrhea
diarrhea
  • diarrhea of presumed infectious origin
functioning pancreatic endocrine tumor
non-functioning pancreatic endocrine tumor
  • non functioning pancreatic endocrine tumor
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NGN3_HUMAN
  • Diarrhea 4, malabsorptive, congenital (DIAR4) [MIM:610370]: A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. {ECO:0000269 PubMed:16855267}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NEUROG3

Genetic Association Database (GAD)
NEUROG3
Human Genome Epidemiology (HuGE) Navigator
NEUROG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEUROG3
genes like me logo Genes that share disorders with NEUROG3: view

No data available for Genatlas for NEUROG3 Gene

Publications for NEUROG3 Gene

  1. Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes. (PMID: 18072012) Li J. … Schwarz P.E. (Exp. Clin. Endocrinol. Diabetes 2008) 3 22 46 64
  2. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. (PMID: 18093211) Louet J.F. … Mauvais-Jarvis F. (Diabetes Obes Metab 2008) 3 22 46 64
  3. Mutant neurogenin-3 in congenital malabsorptive diarrhea. (PMID: 16855267) Wang J. … Martin M.G. (N. Engl. J. Med. 2006) 3 4 22 64
  4. NEUROG3 variants and type 2 diabetes in Italians. (PMID: 17146417) Milord E. … Gragnoli C. (Minerva Med. 2006) 3 22 46 64
  5. Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population. (PMID: 15277395) Jackson A.E. … Hitman G.A. (Diabetes 2004) 3 22 46 64

Products for NEUROG3 Gene

Sources for NEUROG3 Gene

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