Aliases for NEUROG3 Gene
External Ids for NEUROG3 Gene
Previous GeneCards Identifiers for NEUROG3 Gene
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
GeneCards Summary for NEUROG3 Gene
NEUROG3 (Neurogenin 3) is a Protein Coding gene. Diseases associated with NEUROG3 include diarrhea 4, malabsorptive, congenital and congenital malabsorptive diarrhea due to paucity of enteroendocrine cells. Among its related pathways are Regulation of beta-cell development and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NEUROG1.
UniProtKB/Swiss-Prot for NEUROG3 Gene
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).