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Aliases for NEUROG2 Gene

Aliases for NEUROG2 Gene

  • Neurogenin 2 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 8 3 4
  • Protein Atonal Homolog 4 3 4
  • BHLHa8 3 4
  • Atoh4 3 4
  • Ngn-2 3 4
  • NGN2 3 4
  • Math4A 3

External Ids for NEUROG2 Gene

Previous GeneCards Identifiers for NEUROG2 Gene

  • GC00U990846
  • GC04M113715
  • GC04M113827
  • GC04M113893
  • GC04M113792
  • GC04M113654
  • GC04M113434
  • GC04M109166

Summaries for NEUROG2 Gene

Entrez Gene Summary for NEUROG2 Gene

  • This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]

GeneCards Summary for NEUROG2 Gene

NEUROG2 (Neurogenin 2) is a Protein Coding gene. Diseases associated with NEUROG2 include partial fetal alcohol syndrome. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include sequence-specific DNA binding and E-box binding. An important paralog of this gene is NEUROG1.

UniProtKB/Swiss-Prot for NEUROG2 Gene

  • Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3).

Gene Wiki entry for NEUROG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROG2 Gene

Genomics for NEUROG2 Gene

Regulatory Elements for NEUROG2 Gene

Promoters for NEUROG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEUROG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEUROG2 Gene

Chromosome:
4
Start:
112,513,516 bp from pter
End:
112,516,172 bp from pter
Size:
2,657 bases
Orientation:
Minus strand

Genomic View for NEUROG2 Gene

Genes around NEUROG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROG2 Gene

Proteins for NEUROG2 Gene

  • Protein details for NEUROG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2A3-NGN2_HUMAN
    Recommended name:
    Neurogenin-2
    Protein Accession:
    Q9H2A3
    Secondary Accessions:
    • Q8N416

    Protein attributes for NEUROG2 Gene

    Size:
    272 amino acids
    Molecular mass:
    28621 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROG2 Gene

Proteomics data for NEUROG2 Gene at MOPED

Post-translational modifications for NEUROG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NEUROG2 (Neurogenin-2)
  • Cell Signaling Technology (CST) Antibodies for NEUROG2 (neurogenin 2)

No data available for DME Specific Peptides for NEUROG2 Gene

Domains & Families for NEUROG2 Gene

Gene Families for NEUROG2 Gene

Protein Domains for NEUROG2 Gene

Suggested Antigen Peptide Sequences for NEUROG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2A3

UniProtKB/Swiss-Prot:

NGN2_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NEUROG2: view

Function for NEUROG2 Gene

Molecular function for NEUROG2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3).

Gene Ontology (GO) - Molecular Function for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070888 E-box binding ISS --
genes like me logo Genes that share ontologies with NEUROG2: view
genes like me logo Genes that share phenotypes with NEUROG2: view

Animal Models for NEUROG2 Gene

MGI Knock Outs for NEUROG2:

Animal Model Products

miRNA for NEUROG2 Gene

miRTarBase miRNAs that target NEUROG2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROG2 Gene

Localization for NEUROG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROG2 Gene COMPARTMENTS Subcellular localization image for NEUROG2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 2
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NEUROG2 Gene

Pathways & Interactions for NEUROG2 Gene

genes like me logo Genes that share pathways with NEUROG2: view

Pathways by source for NEUROG2 Gene

Gene Ontology (GO) - Biological Process for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030182 neuron differentiation IEA --
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity ISS --
genes like me logo Genes that share ontologies with NEUROG2: view

No data available for SIGNOR curated interactions for NEUROG2 Gene

Drugs & Compounds for NEUROG2 Gene

No Compound Related Data Available

Transcripts for NEUROG2 Gene

mRNA/cDNA for NEUROG2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROG2 Gene

Neurogenin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG2 Gene

No ASD Table

Relevant External Links for NEUROG2 Gene

GeneLoc Exon Structure for
NEUROG2
ECgene alternative splicing isoforms for
NEUROG2

Expression for NEUROG2 Gene

mRNA expression in normal human tissues for NEUROG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEUROG2 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEUROG2 Gene



SOURCE GeneReport for Unigene cluster for NEUROG2 Gene Hs.744415

genes like me logo Genes that share expression patterns with NEUROG2: view

Protein tissue co-expression partners for NEUROG2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NEUROG2 Gene

Orthologs for NEUROG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEUROG2 35
  • 88.4 (n)
  • 92.22 (a)
NEUROG2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROG2 35
  • 90.56 (n)
  • 93.75 (a)
NEUROG2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurog2 35
  • 83.9 (n)
  • 86.31 (a)
Neurog2 16
Neurog2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEUROG2 35
  • 97.67 (n)
  • 96.32 (a)
NEUROG2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurog2 35
  • 84.79 (n)
  • 87.45 (a)
oppossum
(Monodelphis domestica)
Mammalia NEUROG2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEUROG2 35
  • 71.06 (n)
  • 66.47 (a)
lizard
(Anolis carolinensis)
Reptilia NEUROG2 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia X-NGNR-1b 35
fruit fly
(Drosophila melanogaster)
Insecta tap 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for NEUROG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NEUROG2 Gene

ENSEMBL:
Gene Tree for NEUROG2 (if available)
TreeFam:
Gene Tree for NEUROG2 (if available)

Paralogs for NEUROG2 Gene

(3) SIMAP similar genes for NEUROG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEUROG2: view

Variants for NEUROG2 Gene

Sequence variations from dbSNP and Humsavar for NEUROG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs28720880 -- 112,513,123(+) AGTTG(C/T)ACAAA downstream-variant-500B
rs75150208 -- 112,513,022(+) TATAC(A/G)TACTG downstream-variant-500B
rs78404239 -- 112,514,207(+) TACTC(A/G)ACATT utr-variant-3-prime
rs78467282 -- 112,514,328(+) GGAGC(G/T)TCAGT utr-variant-3-prime
rs77541103 -- 112,513,468(+) TTGGC(A/G)TCTAA downstream-variant-500B

Variation tolerance for NEUROG2 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEUROG2 Gene

HapMap Linkage Disequilibrium report
NEUROG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEUROG2 Gene

Disorders for NEUROG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEUROG2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
partial fetal alcohol syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NEUROG2

Genetic Association Database (GAD)
NEUROG2
Human Genome Epidemiology (HuGE) Navigator
NEUROG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEUROG2
genes like me logo Genes that share disorders with NEUROG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEUROG2 Gene

Publications for NEUROG2 Gene

  1. Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. (PMID: 19879328) Deng S. … Jankovic J. (Neurosci. Lett. 2010) 3 23 48 67
  2. Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. (PMID: 17784840) Kumar M. … Mani S. (Stem Cells Dev. 2007) 3 23
  3. Rapid neurogenesis through transcriptional activation in human stem cells. (PMID: 25403753) Busskamp V. … Church G.M. (Mol. Syst. Biol. 2014) 3
  4. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3
  5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3

Products for NEUROG2 Gene

Sources for NEUROG2 Gene

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