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Aliases for NEUROG2 Gene

Aliases for NEUROG2 Gene

  • Neurogenin 2 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 8 3 4
  • Protein Atonal Homolog 4 3 4
  • BHLHa8 3 4
  • Atoh4 3 4
  • Ngn-2 3 4
  • NGN2 3 4
  • Neurogenin-2 3
  • Math4A 3

External Ids for NEUROG2 Gene

Previous GeneCards Identifiers for NEUROG2 Gene

  • GC00U990846
  • GC04M113715
  • GC04M113827
  • GC04M113893
  • GC04M113792
  • GC04M113654
  • GC04M113434
  • GC04M109166

Summaries for NEUROG2 Gene

Entrez Gene Summary for NEUROG2 Gene

  • This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]

GeneCards Summary for NEUROG2 Gene

NEUROG2 (Neurogenin 2) is a Protein Coding gene. Diseases associated with NEUROG2 include Partial Fetal Alcohol Syndrome. Among its related pathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include sequence-specific DNA binding and E-box binding. An important paralog of this gene is NEUROG1.

UniProtKB/Swiss-Prot for NEUROG2 Gene

  • Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3).

Gene Wiki entry for NEUROG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROG2 Gene

Genomics for NEUROG2 Gene

Regulatory Elements for NEUROG2 Gene

Enhancers for NEUROG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G112510 0.5 FANTOM5 21.7 +6.0 5971 0.3 SUZ12 CBX2 TCF7 EZH2 NEUROG2 LOC105377372 ANK2 TOX4P1
GH04G112321 0.9 Ensembl ENCODE 11.7 +194.2 194201 0.5 CTCF PKNOX1 ZNF654 TRIM22 CHD1 ZNF175 REST DPF2 RAD21 KLF16 ZGRF1 LARP7 LOC105377372 NEUROG2 GC04P112321 GC04P112341
GH04G112379 0.9 Ensembl ENCODE 10.7 +136.7 136699 0.5 CTCF BHLHE40 TEAD4 MAX JUND HDAC2 POLR2A SMARCA4 FOS KDM6A NEUROG2 LOC105377372 RTEL1P1 GC04P112446
GH04G112328 0.8 ENCODE 11.7 +188.1 188093 0.1 CTCF PKNOX1 CEBPG RAD21 ARID3A CBX5 ZNF143 SMC3 RELB ZNF654 LARP7 ZGRF1 LOC105377372 NEUROG2 GC04P112321 GC04P112341
GH04G112317 0.8 dbSUPER 11.5 +197.4 197399 2.0 HDGF TBP PKNOX1 MXI1 BACH1 EBF1 POLR2A EED ZNF207 ETV6 LOC105377372 NEUROG2 GC04P112321 TIFA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEUROG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEUROG2 Gene

Chromosome:
4
Start:
112,513,516 bp from pter
End:
112,516,172 bp from pter
Size:
2,657 bases
Orientation:
Minus strand

Genomic View for NEUROG2 Gene

Genes around NEUROG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROG2 Gene

Proteins for NEUROG2 Gene

  • Protein details for NEUROG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2A3-NGN2_HUMAN
    Recommended name:
    Neurogenin-2
    Protein Accession:
    Q9H2A3
    Secondary Accessions:
    • Q8N416

    Protein attributes for NEUROG2 Gene

    Size:
    272 amino acids
    Molecular mass:
    28621 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROG2 Gene

Post-translational modifications for NEUROG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NEUROG2 (Neurogenin-2)
  • Cell Signaling Technology (CST) Antibodies for NEUROG2 (neurogenin 2)

No data available for DME Specific Peptides for NEUROG2 Gene

Domains & Families for NEUROG2 Gene

Gene Families for NEUROG2 Gene

Protein Domains for NEUROG2 Gene

Suggested Antigen Peptide Sequences for NEUROG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEUROG2: view

No data available for UniProtKB/Swiss-Prot for NEUROG2 Gene

Function for NEUROG2 Gene

Molecular function for NEUROG2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3).

Gene Ontology (GO) - Molecular Function for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
GO:0070888 E-box binding ISS --
genes like me logo Genes that share ontologies with NEUROG2: view
genes like me logo Genes that share phenotypes with NEUROG2: view

Animal Models for NEUROG2 Gene

MGI Knock Outs for NEUROG2:

Animal Model Products

miRNA for NEUROG2 Gene

miRTarBase miRNAs that target NEUROG2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROG2 Gene

Localization for NEUROG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEUROG2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEUROG2: view

Pathways & Interactions for NEUROG2 Gene

genes like me logo Genes that share pathways with NEUROG2: view

Pathways by source for NEUROG2 Gene

1 Cell Signaling Technology pathway for NEUROG2 Gene
1 BioSystems pathway for NEUROG2 Gene

Gene Ontology (GO) - Biological Process for NEUROG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NEUROG2: view

No data available for SIGNOR curated interactions for NEUROG2 Gene

Drugs & Compounds for NEUROG2 Gene

No Compound Related Data Available

Transcripts for NEUROG2 Gene

mRNA/cDNA for NEUROG2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROG2 Gene

Neurogenin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG2 Gene

No ASD Table

Relevant External Links for NEUROG2 Gene

GeneLoc Exon Structure for
NEUROG2
ECgene alternative splicing isoforms for
NEUROG2

Expression for NEUROG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEUROG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEUROG2 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEUROG2 Gene



Protein tissue co-expression partners for NEUROG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEUROG2 Gene:

NEUROG2

SOURCE GeneReport for Unigene cluster for NEUROG2 Gene:

Hs.744415

Evidence on tissue expression from TISSUES for NEUROG2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NEUROG2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEUROG2 Gene

Orthologs for NEUROG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROG2 34 35
  • 97.67 (n)
dog
(Canis familiaris)
Mammalia NEUROG2 34 35
  • 90.56 (n)
cow
(Bos Taurus)
Mammalia NEUROG2 34 35
  • 88.4 (n)
rat
(Rattus norvegicus)
Mammalia Neurog2 34
  • 84.79 (n)
mouse
(Mus musculus)
Mammalia Neurog2 34 16 35
  • 83.9 (n)
oppossum
(Monodelphis domestica)
Mammalia NEUROG2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEUROG2 34
  • 71.06 (n)
lizard
(Anolis carolinensis)
Reptilia NEUROG2 35
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia X-NGNR-1b 34
fruit fly
(Drosophila melanogaster)
Insecta tap 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for NEUROG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NEUROG2 Gene

ENSEMBL:
Gene Tree for NEUROG2 (if available)
TreeFam:
Gene Tree for NEUROG2 (if available)

Paralogs for NEUROG2 Gene

(3) SIMAP similar genes for NEUROG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEUROG2: view

Variants for NEUROG2 Gene

Sequence variations from dbSNP and Humsavar for NEUROG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000782099 -- 112,515,422(+) AGCAG(A/C)ACTAA nc-transcript-variant, reference, synonymous-codon
rs1000990135 -- 112,514,837(+) CTCCA(C/T)GTGGA upstream-variant-2KB, reference, synonymous-codon
rs1001897165 -- 112,514,511(+) CAACC(A/G)AGGAA upstream-variant-2KB, utr-variant-3-prime
rs1001983168 -- 112,515,812(+) AACCA(C/T)CTGCG intron-variant
rs1002963445 -- 112,517,060(+) GTCGA(A/C)ACTGG intron-variant, upstream-variant-2KB

Variation tolerance for NEUROG2 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEUROG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEUROG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEUROG2 Gene

Disorders for NEUROG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEUROG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
partial fetal alcohol syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NEUROG2

Genetic Association Database (GAD)
NEUROG2
Human Genome Epidemiology (HuGE) Navigator
NEUROG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEUROG2
genes like me logo Genes that share disorders with NEUROG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEUROG2 Gene

Publications for NEUROG2 Gene

  1. Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. (PMID: 19879328) Deng S. … Jankovic J. (Neurosci. Lett. 2010) 3 22 46 64
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  3. Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. (PMID: 17784840) Kumar M. … Mani S. (Stem Cells Dev. 2007) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Neurogenin 2 enhances the generation of patient-specific induced neuronal cells. (PMID: 25912433) Zhao P. … Li L. (Brain Res. 2015) 3 64

Products for NEUROG2 Gene

Sources for NEUROG2 Gene

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