Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEUROG2 Gene

protein-coding   GIFtS: 54
GCID: GC04M113434

neurogenin 2

 Explore 10 diseases affiliated with
NEUROG2 via our new
 Human Malady Compendium 
Biological research products
for NEUROG2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neurogenin 21 2     Class A Basic Helix-Loop-Helix Protein 82 3
NGN21 2 3     Protein Atonal Homolog 42 3
BHLHa81     Neurogenin-21
Atoh41 2     ATOH43
Math4A1 2     BHLHA83
Ngn-21     NGN-23

External Ids:    HGNC: 138051   Entrez Gene: 639732   Ensembl: ENSG000001784037   OMIM: 6066245   UniProtKB: Q9H2A33   

Export aliases for NEUROG2 gene to outside databases

Previous GC identifers: GC00U990846 GC04M113715 GC04M113827 GC04M113893 GC04M113792 GC04M113654 GC04M109166


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEUROG2:
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate
on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous
systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain
dopaminergic neurons. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3
Function: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E
box (5'-CANNTG-3')

Gene Wiki entry for NEUROG2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEUROG2 gene promoter:
         GR   NRSF form 1   GR-beta   Lmo2   POU3F2 (N-Oct-5a)   HEN1   S8   CP2   COMP1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEUROG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

NEUROG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROG2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M113434:  view genomic region     (about GC identifiers)

Start:
113,434,672 bp from pter      End:
113,437,328 bp from pter
Size:
2,657 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3 (See protein sequence)
Recommended Name: Neurogenin-2  
Size: 272 amino acids; 28621 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8N416

Explore the universe of human proteins at neXtProt for NEUROG2: NX_Q9H2A3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2A3

  • NEUROG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_076924.1  
    ENSEMBL proteins: 
     ENSP00000317333  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NEUROG2
    OriGene Custom Protein Services for NEUROG2 
    GenScript Custom Purified and Recombinant Proteins Services for NEUROG2
    Novus Biologicals NEUROG2 Proteins
    Novus Biologicals NEUROG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NEUROG2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    NEUROG2 for ontologies           About GeneDecksing



    NEUROG2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROG2
    R&D Systems Antibodies for NEUROG2 (Neurogenin-2)
    OriGene Antibodies (see all 2): NEUROG2
    OriGene Custom Antibody Services for NEUROG2 
    GenScript Custom Superior Antibodies Services for NEUROG2
    Novus Biologicals NEUROG2 Antibodies
    Abcam antibodies for NEUROG2 
    Uscn Antibodies for NEUROG2
    ThermoFisher Antibodies for NEUROG2

    Assay Products for NEUROG2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEUROG2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NEUROG2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NEUROG2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2A3

    ProtoNet protein and cluster: Q9H2A3

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3
    Function: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E
    box (5'-CANNTG-3')

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: NEUROG2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROG2
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROG2 (see all 72):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-3605-3p hsa-miR-1260b hsa-miR-374a hsa-miR-632 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROG2 (see all 4)
    OriGene shRNA RFP: NEUROG2
    OriGene siRNA: NEUROG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEUROG2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEUROG2 (NM_024019)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NEUROG2
    Search LifeMap BioReagents cell lines for NEUROG2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046983protein dimerization activity IEA--
    GO:0070888E-box binding ISS--


    NEUROG2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NEUROG2:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Neurog2tm1Fgu for NEUROG2
         8 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Neurog2):
     behavior/neurological  cellular  growth/size  mortality/aging  nervous system 
     no phenotypic analysis  reproductive system  vision/eye 

    NEUROG2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NEUROG2
        Transcription factors in neurogenesis




    NEUROG2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEUROG2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for NEUROG2 (Q9H2A32, 3 ENSP000003173334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCL1P505533, ENSP000002667444I2D: score=1 STRING: ENSP00000266744
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    --P310162MINT-8108650
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007411axon guidance IEA--
    GO:0021954central nervous system neuron development IEA--
    GO:0022008neurogenesis ----


    NEUROG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEUROG2
    Search CenterWatch for drugs/clinical trials and news about NEUROG2 / NGN2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEUROG2 gene: 
    NM_024019.3  

    Unigene Cluster for NEUROG2:

    Neurogenin 2
    Hs.744415  [show with all ESTs]
    Unigene Representative Sequence: NM_024019
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313341(uc003ias.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: NEUROG2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROG2
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROG2 (see all 72):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-3605-3p hsa-miR-1260b hsa-miR-374a hsa-miR-632 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROG2 (see all 4)
    OriGene shRNA RFP: NEUROG2
    OriGene siRNA: NEUROG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROG2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEUROG2 (NM_024019)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROG2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEUROG2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG2

    Additional cDNA sequence: BC036847.1 

    2 DOTS entries:

    DT.40296987  DT.100744096 

    11 AceView cDNA sequences:

    AA775240 CR615296 AI018422 NM_024019 BC036847 AL540071 BX451659 BX445903 
    AA333330 BI917790 AL568209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEUROG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    NEUROG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerGanglion Precursor CellsGanglion, Retina
    EyeNeuroblastic LayerEarly Retinal Progenitor CellsRetina
    EyeGanglion Cell LayerCholinergic Amacrine CellsAmacrine, Retina
    EyeGanglion Cell LayerDisplaced Amacrine CellsAmacrine, Retina
    EyeGanglion Cell LayerDopaminergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerBipolar Precursor CellsBipolar, Retina
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerDopaminergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Neural TubeDiencephalic Ventricular ZoneMeso-diencephalic Dopaminergic Precursor CellsDopaminergic neurons
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See NEUROG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEUROG2

    SOURCE GeneReport for Unigene cluster: Hs.744415
        SABiosciences Expression via Pathway-Focused PCR Arrays including NEUROG2: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROG2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEUROG2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEUROG2 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NEUROG21 neurogenin 2 74.43(n)
    69.31(a)
      395577  NM_204796.1  NP_990127.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEUROG26
    --
    55(a)
    1 ↔ 1
    5(143048593-143049312)
    African clawed frog
    (Xenopus laevis)
    Amphibia X-NGNR-1b2 neurogenin-related 1b 77.02(n)    U67779.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tap6
    target of Poxn
    16(a)
    1 → many
    3L(17352782-17354911)
    worm
    (Caenorhabditis elegans)
    Secernentea ngn-16
    NeuroGeNin family member (ngn-1)
    26(a)
    1 → many
    IV(2626130-2628228)


    ENSEMBL Gene Tree for NEUROG2 (if available)
    TreeFam Gene Tree for NEUROG2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEUROG2 gene
    NEUROG32  FERD3L2  NEUROD22  NEUROD12  NEUROD62  ATOH12  BHLHA152  PTF1A2  
    ATOH72  NEUROG12  NEUROD42  
    3 SIMAP similar genes for NEUROG2 using alignment to 1 protein entry:     NGN2_HUMAN:
    NEUROG1    TAL2    NEUROG3

    NEUROG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEUROG2
    DNA2.0 Custom Variant and Variant Library Synthesis for NEUROG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NEUROG2 for disorders           About GeneDecksing

    OMIM gene information: 606624    OMIM disorders: --

    10 diseases for NEUROG2:    About MalaCards
    supratentorial primitive neuroectodermal tumor    primitive neuroectodermal tumor    neuronitis    alcohol dependence
    neuroectodermal tumors    parkinson's disease    alcoholism    cerebritis
    neuroblastoma    retinitis

    Human Genome Epidemiology (HuGE) Navigator: NEUROG2 (2 documents)

    Export disorders for NEUROG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEUROG2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with NEUROG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. (PubMed id 17784840)1, 9 Kumar M....Mani S. (2007)
    3. Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. (PubMed id 19879328)1, 9 Deng S....Jankovic J. (2010)
    4. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
    5. Grafted human embryonic progenitors expressing neurog enin-2 stimulate axonal sprouting and improve motor recovery after severe spina l cord injury. (PubMed id 21209909)1 Perrin F.E....Privat A. (2010)
    6. Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro. (PubMed id 18242186)1 Park C.H....Lee S.H. (2008)
    7. Geminin regulates neuronal differentiation by antagon izing Brg1 activity. (PubMed id 16024661)1 Seo S....Kroll K.L. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers. (PubMed id 11203697)1 Simmons A.D....Johnson J.E. (2001)
    10. neurogenin2 elicits the genesis of retinal neurons fro m cultures of nonneural cells. (PubMed id 11752450)1 Yan R.T....Wang S.Z. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63973 HGNC: 13805 AceView: NEUROG2 Ensembl:ENSG00000178403 euGenes: HUgn63973
    ECgene: NEUROG2 H-InvDB: NEUROG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEUROG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEUROG2 gene:
    Search GeneIP for patents involving NEUROG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROG2
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NEUROG2 (Neurogenin-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NEUROG2   OriGene shRNA RFP for NEUROG2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROG2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROG2  
     OriGene Protein Over-expression Lysate for NEUROG2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NEUROG2   OriGene 3'-UTR Clone for NEUROG2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEUROG2   OriGene Custom Protein Services for NEUROG2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEUROG2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEUROG2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROG2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROG2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG2
     GenScript Custom Purified and Recombinant Proteins Services for NEUROG2 GenScript cDNA clones with any tag delivered in your preferred vector for NEUROG2
     GenScript Custom Assay Services for NEUROG2 GenScript Custom Superior Antibodies Services for NEUROG2
     GenScript Custom overexpressing Cell Line Services for NEUROG2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NEUROG2 promoter
     Search Chromatin IP Primers for NEUROG2
     RT2 qPCR Primer Assay in human, mouse, rat NEUROG2
     Search GNC Networks for NEUROG2
     SABiosciences PCR Arrays including human, mouse, rat NEUROG2
     Search Tocris compounds for NEUROG2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NEUROG2 antibodies
     NEUROG2 proteins
     NEUROG2 lysates
     Antibodies for NEUROG2
     See all of Abcam's Antibodies, Kits and Proteins for NEUROG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NEUROG2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NEUROG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2
     SwitchGear 3'UTR luciferase reporter plasmids for NEUROG2
     SwitchGear Promoter luciferase reporter plasmids for NEUROG2
     ThermoFisher Antibodies for NEUROG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NEUROG2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4