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NEUROG2 Gene

protein-coding   GIFtS: 51
GCID: GC04M113434

Neurogenin 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neurogenin 21 2     Atoh42
NGN22 3 5     Math4A2
Class A Basic Helix-Loop-Helix Protein 82 3     neurogenin-22
Protein Atonal Homolog 42 3     ngn-22
bHLHa82 3     BHLHA83
ATOH43 5     NGN-23

External Ids:    HGNC: 138051   Entrez Gene: 639732   Ensembl: ENSG000001784037   OMIM: 6066245   UniProtKB: Q9H2A33   

Export aliases for NEUROG2 gene to outside databases

Previous GC identifers: GC00U990846 GC04M113715 GC04M113827 GC04M113893 GC04M113792 GC04M113654 GC04M109166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEUROG2 Gene:
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal
fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral
nervous systems. The protein product of this gene also plays a role in the differentiation and survival of
midbrain dopaminergic neurons. (provided by RefSeq, Apr 2012)

GeneCards Summary for NEUROG2 Gene:
NEUROG2 (neurogenin 2) is a protein-coding gene. Diseases associated with NEUROG2 include supratentorial primitive neuroectodermal tumor, and primitive neuroectodermal tumor. GO annotations related to this gene include E-box binding and sequence-specific DNA binding. An important paralog of this gene is NEUROG3.

UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3
Function: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to
the E box (5'-CANNTG-3')

Gene Wiki entry for NEUROG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NEUROG2 gene promoter:
         GR   NRSF form 1   GR-beta   Lmo2   POU3F2 (N-Oct-5a)   HEN1   S8   CP2   COMP1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROG2 promoter sequence
   Search Chromatin IP Primers for NEUROG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEUROG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

NEUROG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROG2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M113434:  view genomic region     (about GC identifiers)

Start:
113,434,672 bp from pter      End:
113,437,328 bp from pter
Size:
2,657 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3 (See protein sequence)
Recommended Name: Neurogenin-2  
Size: 272 amino acids; 28621 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Secondary accessions: Q8N416

Explore the universe of human proteins at neXtProt for NEUROG2: NX_Q9H2A3

Explore proteomics data for NEUROG2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NEUROG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076924.1  
    ENSEMBL proteins: 
     ENSP00000317333  

    NEUROG2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NEUROG2
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    Novus Biologicals NEUROG2 Proteins
    Novus Biologicals NEUROG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NEUROG2

    NEUROG2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROG2
    R&D Systems Antibodies for NEUROG2 (Neurogenin-2)
    OriGene Antibodies for NEUROG2
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    Novus Biologicals NEUROG2 Antibodies
    Abcam antibodies for NEUROG2
    Cloud-Clone Corp. Antibodies for NEUROG2
    ThermoFisher Antibodies for NEUROG2
    LSBio Antibodies in human, mouse, rat for NEUROG2

    NEUROG2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NEUROG2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEUROG2
    Cloud-Clone Corp. CLIAs for NEUROG2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2A3

    ProtoNet protein and cluster: Q9H2A3

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    NEUROG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NGN2_HUMAN, Q9H2A3
    Function: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to
    the E box (5'-CANNTG-3')

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046983protein dimerization activity IEA--
    GO:0070888E-box binding ISS--
         
    NEUROG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NEUROG2:
     Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Neurog2):
     behavior/neurological  cellular  growth/size/body  mortality/aging  nervous system 
     no phenotypic analysis  reproductive system  vision/eye 

    NEUROG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neurog2tm1Fgu for NEUROG2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEUROG2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEUROG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEUROG2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEUROG2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NEUROG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEUROG2 (see all 72):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-3605-3p hsa-miR-1260b hsa-miR-374a hsa-miR-632 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEUROG2
    Predesigned siRNA for gene silencing in human, mouse, rat NEUROG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEUROG2

    Clone
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    OriGene clones in human, mouse for NEUROG2 (see all 8)
    OriGene ORF clones in mouse, rat for NEUROG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROG2 (NM_024019)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NEUROG2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NGN2_HUMAN, Q9H2A3: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    extracellular2
    cytoskeleton1
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NEUROG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEUROG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis



        Pathway & Disease-focused RT2 Profiler PCR Arrays including NEUROG2: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NEUROG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NEUROG2 (Q9H2A32, 3 ENSP000003173334) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCL1P505533, ENSP000002667444I2D: score=1 STRING: ENSP00000266744
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    TCF12ENSP000003310574STRING: ENSP00000331057
    TCF3ENSP000002629654STRING: ENSP00000262965
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007411axon guidance IEA--
    GO:0021954central nervous system neuron development IEA--
    GO:0022008neurogenesis ----

    NEUROG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEUROG2 (NGN2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEUROG2 gene: 
    NM_024019.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313341(uc003ias.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NEUROG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEUROG2 (see all 72):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-3605-3p hsa-miR-1260b hsa-miR-374a hsa-miR-632 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NEUROG2
    Predesigned siRNA for gene silencing in human, mouse, rat NEUROG2
    Clone
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    OriGene clones in human, mouse for NEUROG2 (see all 8)
    OriGene ORF clones in mouse, rat for NEUROG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROG2 (NM_024019)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NEUROG2
    OriGene qSTAR qPCR primer pairs in human, mouse for NEUROG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEUROG2
      QuantiTect SYBR Green Assays in human, mouse, rat NEUROG2
      QuantiFast Probe-based Assays in human, mouse, rat NEUROG2

    11 AceView cDNA sequences:

    CR615296 NM_024019 AI018422 AA775240 BC036847 AL540071 BX451659 AA333330 
    BX445903 BI917790 AL568209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEUROG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEUROG2 Expression
    About this image


    NEUROG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 14 entries
             Meso-diencephalic Dopaminergic Precursor Cells Mesencephalic Ventricular Zone
             Metencephalon
             Floor plate-like cells
     
     Neurons
             Motor Neural Progenitor Cells Motor Neural Progenitor Domain
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
             Midbrain tegmentum
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Motor Neural Progenitor Cells Motor Neural Progenitor Domain
             Retinoic acid- and Sonic hedgehog-induced neural rosettes
     
     Eye (Sensory Organs)    fully expand to see all 9 entries
             Ganglion Precursor Cells Ganglion Cell Layer
    NEUROG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEUROG2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NEUROG2: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NEUROG2
    OriGene qSTAR qPCR primer pairs in human, mouse for NEUROG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEUROG2
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    QuantiFast Probe-based Assays in human, mouse, rat NEUROG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEUROG2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurog21 , 5 neurogenin 21, 5 83.9(n)1
    86.31(a)1
      3 (56.54 cM)5
    119241  NM_009718.21  NP_033848.11 
     1276331365 
    chicken
    (Gallus gallus)
    Aves NEUROG21 neurogenin 2 71.06(n)
    66.47(a)
      395577  NM_204796.1  NP_990127.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEUROG26
    neurogenin 2
    60(a)
    1 ↔ 1
    5(143048593-143049312)
    African clawed frog
    (Xenopus laevis)
    Amphibia X-NGNR-1b2 neurogenin-related 1b 77.02(n)    U67779.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tap6
    target of Poxn
    18(a)
    1 → many
    3L(17352782-17354911)


    ENSEMBL Gene Tree for NEUROG2 (if available)
    TreeFam Gene Tree for NEUROG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEUROG2 gene
    NEUROG32  NEUROD22  NEUROD12  NEUROD62  ATOH12  BHLHA152  ATOH72  NEUROG12  
    NEUROD42  
    3 SIMAP similar genes for NEUROG2 using alignment to 1 protein entry:     NGN2_HUMAN:
    NEUROG1    TAL2    NEUROG3

    NEUROG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEUROG2 (see all 87)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs751502081,2
    F--113434178(+) TATACG/ATACTG 1 -- int11Minor allele frequency- A:0.07WA 118
    rs287208801,2
    C--113434279(+) AGTTGC/TACAAA 1 -- int13Minor allele frequency- T:0.05CSA WA EA 240
    rs1141976261,2
    C,F--113434418(+) TGTTTG/TCTCAG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs602734901,2
    C--113434461(+) CTTAA-/AAATAGAA 1 -- int10--------
    rs1875663451,2
    --113434464(+) TTAAAA/CATAGA 1 -- int10--------
    rs775411031,2
    F--113434624(+) TTGGCA/GTCTAA 1 -- int10--------
    rs1928061681,2
    --113434827(+) AACACG/TTGTGT 1 -- ut310--------
    rs1830681611,2
    --113435004(+) TTTGAC/TAGAGA 1 -- ut310--------
    rs1878220591,2
    --113435065(+) TTATAC/TAATGA 1 -- ut310--------
    rs784042391,2
    C,F--113435363(+) TACTCG/AACATT 1 -- ut311Minor allele frequency- A:0.02EA 120

    HapMap Linkage Disequilibrium report for NEUROG2 (113434672 - 113437328 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NEUROG2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEUROG2
    DNA2.0 Custom Variant and Variant Library Synthesis for NEUROG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606624    OMIM disorders: --

    9 diseases for NEUROG2:    
    About MalaCards
    supratentorial primitive neuroectodermal tumor    primitive neuroectodermal tumor    alcohol dependence    neuronitis
    spinal cord injury    neuroblastoma    parkinson's disease    retinitis
    cerebritis

    1 disease from the University of Copenhagen DISEASES database for NEUROG2:
    Supratentorial primitive neuroectodermal tumor

    NEUROG2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NEUROG2
    Human Genome Epidemiology (HuGE) Navigator: NEUROG2 (2 documents)

    Export disorders for NEUROG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEUROG2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with NEUROG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. (PubMed id 19879328)1, 4, 9 Deng S....Jankovic J. (Neurosci. Lett. 2010)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. (PubMed id 17784840)1, 9 Kumar M....Mani S. (Stem Cells Dev. 2007)
    5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    6. Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. (PubMed id 21209909)1 Perrin F.E....Privat A. (PLoS ONE 2010)
    7. Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro. (PubMed id 18242186)1 Park C.H....Lee S.H. (FEBS Lett. 2008)
    8. Geminin regulates neuronal differentiation by antagonizing Brg1 activity. (PubMed id 16024661)1 Seo S....Kroll K.L. (amp 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers. (PubMed id 11203697)1 Simmons A.D....Johnson J.E. (Dev. Biol. 2001)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63973 HGNC: 13805 AceView: NEUROG2 Ensembl:ENSG00000178403 euGenes: HUgn63973
    ECgene: NEUROG2 H-InvDB: NEUROG2

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEUROG2 Pharmacogenomics, SNPs, Pathways

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