NEUROG2 Gene
protein-coding GIFtS : 54
GCID: GC04 M113434
neurogenin 2
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Aliasesfor NEUROG2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Neurogenin 2 1 2 Class A Basic Helix-Loop-Helix Protein 82 3 NGN21 2 3 Protein Atonal Homolog 42 3 BHLHa81 Neurogenin-21 Atoh41 2 ATOH43 Math4A1 2 BHLHA83 Ngn-21 NGN-23
Export aliases for NEUROG2 gene to outside databases Previous GC identifers: GC00U990846 GC04M113715 GC04M113827 GC04M113893 GC04M113792 GC04M113654 GC04M109166
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Summariesfor NEUROG2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for NEUROG2 : This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. (provided by RefSeq, Apr 2012) UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3 Function : Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the Ebox (5'-CANNTG-3') Gene Wiki entry for NEUROG2
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Genomic Viewsfor NEUROG2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NEUROG2 gene promoter: GR NRSF form 1 GR-beta Lmo2 POU3F2 (N-Oct-5a) HEN1 S8 CP2 COMP1 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for NEUROG2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NEUROG2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25 NEUROG2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M113434: view genomic region
(about GC identifiers )
Start:
113,434,672 bp from pter
End:
113,437,328 bp from pter
Size:
2,657 bases
Orientation:
minus strand
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Proteinsfor NEUROG2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3 (See
protein sequence )Recommended Name: Neurogenin-2 Size : 272 amino acids; 28621 Da
Subunit : Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location : Nucleus (Potential)
Secondary accessions : Q8N416Explore the universe of human proteins at neXtProt for NEUROG2: NX_Q9H2A3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H2A3 NEUROG2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_076924.1 ENSEMBL proteins: ENSP00000317333 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
NEUROG2 for ontologies About GeneDecksing NEUROG2 Antibody Products: Assay Products for NEUROG2:
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Protein
Domains / Familiesfor NEUROG2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NEUROG2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9H2A3 ProtoNet protein and cluster: Q9H2A3
1 Blocks protein family : IPB001092 Basic helix-loop-helix dimerization domain bHLH UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3 Similarity : Contains 1 bHLH (basic helix-loop-helix) domain
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Functionfor NEUROG2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3 Function : Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the Ebox (5'-CANNTG-3')
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NEUROG2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NEUROG2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NEUROG2 (NM_024019 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEUROG2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NEUROG2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
NEUROG2 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for NEUROG2 :Animal Models: Mouse knock-out Neurog2 tm1Fgu for NEUROG2 8 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Neurog2) :
NEUROG2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor NEUROG2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Transcription factors in neurogenesis
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for NEUROG2
NEUROG2 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEUROG2 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)4 Interacting proteins for NEUROG2 (Q9H2A3 2 , 3 ENSP00000317333 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
NEUROG2 for ontologies About GeneDecksing
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Drugs & Compoundsfor NEUROG2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NEUROG2 Search CenterWatch for drugs/clinical trials and news about NEUROG2 / NGN2
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Transcriptsfor NEUROG2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NEUROG2 gene: NM_024019.3 Unigene Cluster for NEUROG2:
Neurogenin 2 Hs.744415 [show with all ESTs ] Unigene Representative Sequence: NM_024019 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000313341 (uc003ias.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NEUROG2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NEUROG2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NEUROG2 (NM_024019 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEUROG2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NEUROG2
Additional cDNA sequence: BC036847.1
2 DOTS entries : DT.40296987 DT.100744096
11 AceView cDNA sequences :
AA775240 CR615296 AI018422 NM_024019 BC036847 AL540071 BX451659 BX445903 AA333330 BI917790 AL568209 GeneLoc Exon Structure
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Expression for NEUROG2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NEUROG2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image NEUROG2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See NEUROG2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NEUROG2 SOURCE GeneReport for Unigene cluster: Hs.744415 SABiosciences Expression via Pathway-Focused PCR Arrays including NEUROG2 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NEUROG2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NEUROG2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NEUROG2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NEUROG2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2
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Orthologsfor NEUROG2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for NEUROG2 gene from 5/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
NEUROG21
neurogenin 2
74.43(n) 69.31(a)
 
395577 NM_204796.1 NP_990127.1
lizard (Anolis carolinensis)
Reptilia
NEUROG26
--
55(a)
1 ↔ 1
5(143048593-143049312)
African clawed frog (Xenopus laevis)
Amphibia
X-NGNR-1b2
neurogenin-related 1b
77.02(n)
 
U67779.1
fruit fly (Drosophila melanogaster)
Insecta
tap6
target of Poxn
16(a)
1 → many
3L(17352782-17354911)
worm (Caenorhabditis elegans)
Secernentea
ngn-16
NeuroGeNin family member (ngn-1)
26(a)
1 → many
IV(2626130-2628228)
ENSEMBL Gene Tree for NEUROG2 (if available)TreeFam Gene Tree for NEUROG2 (if available)
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Paralogsfor NEUROG2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NEUROG2 gene NEUROG3 2 FERD3L 2 NEUROD2 2 NEUROD1 2 NEUROD6 2 ATOH1 2 BHLHA15 2 PTF1A 2 ATOH7 2 NEUROG1 2 NEUROD4 2 3 SIMAP similar genes for NEUROG2 using alignment to 1 protein entry: NGN2_HUMAN :NEUROG1 TAL2 NEUROG3
NEUROG2 for paralogs About GeneDecksing
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Genomic Variantsfor NEUROG2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NEUROG2
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Disorders
/ Diseasesfor NEUROG2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NEUROG2 for disorders About GeneDecksing
OMIM gene information: 606624
OMIM disorders : --10 diseases for NEUROG2 : About MalaCards supratentorial primitive neuroectodermal tumor primitive neuroectodermal tumor neuronitis alcohol dependence neuroectodermal tumors parkinson's disease alcoholism cerebritis neuroblastoma retinitis Human Genome Epidemiology (HuGE) Navigator: NEUROG2 (2 documents) Export disorders for NEUROG2 gene to outside databases
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Publicationsfor NEUROG2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NEUROG2 gene, integrated from 9 sources (see all 38 ): (articles sorted by number of sources associating them with NEUROG2) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. (PubMed id 17784840) 1 , 9 Kumar M....Mani S. (2007) Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. (PubMed id 19879328) 1 , 9 Deng S....Jankovic J. (2010) A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099) 1 Kalsi G....Riley B.P. (2010) Grafted human embryonic progenitors expressing neurog enin-2 stimulate axonal sprouting and improve motor recovery after severe spina l cord injury. (PubMed id 21209909) 1 Perrin F.E....Privat A. (2010) Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro. (PubMed id 18242186) 1 Park C.H....Lee S.H. (2008) Geminin regulates neuronal differentiation by antagon izing Brg1 activity. (PubMed id 16024661) 1 Seo S....Kroll K.L. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers. (PubMed id 11203697) 1 Simmons A.D....Johnson J.E. (2001) neurogenin2 elicits the genesis of retinal neurons fro m cultures of nonneural cells. (PubMed id 11752450) 1 Yan R.T....Wang S.Z. (2001)
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External Searches for NEUROG2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NEUROG2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NEUROG2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NEUROG2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NEUROG2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NEUROG2 gene: Search GeneIP for patents involving NEUROG2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NEUROG2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for NEUROG2 OriGene shRNA RFP for NEUROG2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NEUROG2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NEUROG2 OriGene Protein Over-expression Lysate for NEUROG2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NEUROG2 OriGene 3'-UTR Clone for NEUROG2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NEUROG2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NEUROG2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NEUROG2 OriGene Custom Protein Services for NEUROG2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEUROG2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NEUROG2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NEUROG2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NEUROG2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NEUROG2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NEUROG2
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NEUROG2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2
ThermoFisher Antibodies for NEUROG2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NEUROG2
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