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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEUROG2 Gene

protein-coding   GIFtS: 55
GCID: GC04M113434

Neurogenin 2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurogenin 21 2     Math4A2
Class A Basic Helix-Loop-Helix Protein 82 3     neurogenin-22
Protein Atonal Homolog 42 3     ngn-22
NGN22 3     ATOH43
bHLHa82 3     BHLHA83
Atoh42     NGN-23

External Ids:    HGNC: 138051   Entrez Gene: 639732   Ensembl: ENSG000001784037   OMIM: 6066245   UniProtKB: Q9H2A33   

Export aliases for NEUROG2 gene to outside databases

Previous GC identifers: GC00U990846 GC04M113715 GC04M113827 GC04M113893 GC04M113792 GC04M113654 GC04M109166


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEUROG2 Gene:
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal
fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral
nervous systems. The protein product of this gene also plays a role in the differentiation and survival of
midbrain dopaminergic neurons. (provided by RefSeq, Apr 2012)

GeneCards Summary for NEUROG2 Gene: 
NEUROG2 (neurogenin 2) is a protein-coding gene. Diseases associated with NEUROG2 include supratentorial primitive neuroectodermal tumor, and alcohol dependence. GO annotations related to this gene include E-box binding and sequence-specific DNA binding. An important paralog of this gene is NEUROG3.

UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3
Function: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to
the E box (5'-CANNTG-3')

Gene Wiki entry for NEUROG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEUROG2 gene promoter:
         GR   NRSF form 1   GR-beta   Lmo2   POU3F2 (N-Oct-5a)   HEN1   S8   CP2   COMP1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEUROG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

NEUROG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROG2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M113434:  view genomic region     (about GC identifiers)

Start:
113,434,672 bp from pter      End:
113,437,328 bp from pter
Size:
2,657 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3 (See protein sequence)
Recommended Name: Neurogenin-2  
Size: 272 amino acids; 28621 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8N416

Explore the universe of human proteins at neXtProt for NEUROG2: NX_Q9H2A3

Explore proteomics data for NEUROG2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2A3

  • NEUROG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEUROG2 Protein Expression
    REFSEQ proteins: NP_076924.1  
    ENSEMBL proteins: 
     ENSP00000317333  

    Human Recombinant Protein Products for NEUROG2: 
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    Novus Biologicals NEUROG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEUROG2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NEUROG2 for ontologies           About GeneDecksing



    NEUROG2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for NEUROG2 
    Cloud-Clone Corp. CLIAs for NEUROG2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2A3

    ProtoNet protein and cluster: Q9H2A3

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NGN2_HUMAN, Q9H2A3
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    NEUROG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NGN2_HUMAN, Q9H2A3
    Function: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to
    the E box (5'-CANNTG-3')

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046983protein dimerization activity IEA--
    GO:0070888E-box binding ISS--
         
    NEUROG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NEUROG2:
     Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Neurog2):
     behavior/neurological  cellular  growth/size  mortality/aging  nervous system 
     no phenotypic analysis  reproductive system  vision/eye 

    NEUROG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neurog2tm1Fgu for NEUROG2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEUROG2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEUROG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEUROG2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEUROG2 

    miRNA
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    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROG2 (see all 72):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-3605-3p hsa-miR-1260b hsa-miR-374a hsa-miR-632 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for NEUROG2
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of NEUROG2 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEUROG2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NEUROG2
        Transcription factors in neurogenesis




    NEUROG2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEUROG2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for NEUROG2 (Q9H2A32, 3 ENSP000003173334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCL1P505533, ENSP000002667444I2D: score=1 STRING: ENSP00000266744
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    --P310162MINT-8108650
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007411axon guidance IEA--
    GO:0021954central nervous system neuron development IEA--
    GO:0022008neurogenesis ----

    NEUROG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEUROG2 (NGN2)

    Search CenterWatch for drugs/clinical trials and news about NEUROG2 / NGN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEUROG2 gene: 
    NM_024019.3  

    Unigene Cluster for NEUROG2:

    Neurogenin 2
    Hs.744415  [show with all ESTs]
    Unigene Representative Sequence: NM_024019
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313341(uc003ias.3)

    miRNA
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    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROG2 (see all 72):
    hsa-miR-3194-5p hsa-miR-300 hsa-miR-106a hsa-miR-3605-3p hsa-miR-1260b hsa-miR-374a hsa-miR-632 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEUROG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROG2
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG2

    Additional mRNA sequence: BC036847.1 

    2 DOTS entries:

    DT.40296987  DT.100744096 

    11 AceView cDNA sequences:

    NM_024019 BC036847 AA775240 CR615296 AI018422 BX451659 AL540071 AA333330 
    BX445903 BI917790 AL568209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEUROG2 expression in normal human tissues (normalized intensities)      NEUROG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEUROG2 Expression
    About this image


    NEUROG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 31 entries
             Meso-diencephalic Dopaminergic Precursor Cells Mesencephalic Ventricular Zone
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)    fully expand to see all 13 entries
             Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 10 entries
             Ganglion Precursor Cells Ganglion Cell Layer
             Retina
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Motor Neural Progenitor Cells Motor Neural Progenitor Domain
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Human Neuron (HN)   

    See NEUROG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEUROG2

    SOURCE GeneReport for Unigene cluster: Hs.744415
        SABiosciences Expression via Pathway-Focused PCR Arrays including NEUROG2: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEUROG2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurog21 , 5 neurogenin 21, 5 84.66(n)1
    87.07(a)1
      3 (56.54 cM)5
    119241  NM_009718.21  NP_033848.11 
     1276331365 
    chicken
    (Gallus gallus)
    Aves NEUROG21 neurogenin 2 74.43(n)
    69.31(a)
      395577  NM_204796.1  NP_990127.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEUROG26
    Uncharacterized protein
    56(a)
    1 ↔ 1
    5(143048593-143049312)
    African clawed frog
    (Xenopus laevis)
    Amphibia X-NGNR-1b2 neurogenin-related 1b 77.02(n)    U67779.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tap6
    target of Poxn
    16(a)
    1 → many
    3L(17352782-17354911)
    worm
    (Caenorhabditis elegans)
    Secernentea cnd-16
    ngn-16
    Protein NGN-1
    27(a)
    24(a)
    possible ortholog
    1 ↔ many
    III(5240593-5242108)
    IV(2626132-2628230)


    ENSEMBL Gene Tree for NEUROG2 (if available)
    TreeFam Gene Tree for NEUROG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEUROG2 gene
    NEUROG32  NEUROD22  NEUROD12  NEUROD62  ATOH12  BHLHA152  ATOH72  NEUROG12  
    NEUROD42  
    3 SIMAP similar genes for NEUROG2 using alignment to 1 protein entry:     NGN2_HUMAN:
    NEUROG1    TAL2    NEUROG3

    NEUROG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 SNPs in NEUROG2 are shown (see all 87)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs751502081,2
    F--113434178(+) TATACG/ATACTG 1 -- int11Minor allele frequency- A:0.07WA 118
    rs287208801,2
    C--113434279(+) AGTTGC/TACAAA 1 -- int13Minor allele frequency- T:0.05CSA WA EA 240
    rs1141976261,2
    C,F--113434418(+) TGTTTG/TCTCAG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs602734901,2
    C--113434461(+) CTTAA-/AAATAGAA 1 -- int10--------
    rs1875663451,2
    --113434464(+) TTAAAA/CATAGA 1 -- int10--------
    rs775411031,2
    F--113434624(+) TTGGCA/GTCTAA 1 -- int10--------
    rs1928061681,2
    --113434827(+) AACACG/TTGTGT 1 -- ut310--------
    rs1830681611,2
    --113435004(+) TTTGAC/TAGAGA 1 -- ut310--------
    rs1878220591,2
    --113435065(+) TTATAC/TAATGA 1 -- ut310--------
    rs784042391,2
    C,F--113435363(+) TACTCG/AACATT 1 -- ut311Minor allele frequency- A:0.02EA 120

    HapMap Linkage Disequilibrium report for NEUROG2 (113434672 - 113437328 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NEUROG2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NEUROG2
    DNA2.0 Custom Variant and Variant Library Synthesis for NEUROG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606624    OMIM disorders: --

    9 diseases for NEUROG2:    About MalaCards
    supratentorial primitive neuroectodermal tumor    alcohol dependence    primitive neuroectodermal tumor    alcoholism
    neuronitis    neuroblastoma    parkinson's disease    retinitis
    cerebritis

    1 disease from the University of Copenhagen DISEASES database for NEUROG2:
    Supratentorial primitive neuroectodermal tumor

    NEUROG2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NEUROG2
    Human Genome Epidemiology (HuGE) Navigator: NEUROG2 (2 documents)

    Export disorders for NEUROG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEUROG2 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with NEUROG2)
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    1. Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. (PubMed id 19879328)1, 4, 9 Deng S....Jankovic J. (2010)
    2. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells. (PubMed id 17784840)1, 9 Kumar M....Mani S. (2007)
    5. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    6. Grafted human embryonic progenitors expressing neurog enin-2 stimulate axonal sprouting and improve motor recovery after severe spina l cord injury. (PubMed id 21209909)1 Perrin F.E....Privat A. (2010)
    7. Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro. (PubMed id 18242186)1 Park C.H....Lee S.H. (2008)
    8. Geminin regulates neuronal differentiation by antagon izing Brg1 activity. (PubMed id 16024661)1 Seo S....Kroll K.L. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers. (PubMed id 11203697)1 Simmons A.D....Johnson J.E. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63973 HGNC: 13805 AceView: NEUROG2 Ensembl:ENSG00000178403 euGenes: HUgn63973
    ECgene: NEUROG2 H-InvDB: NEUROG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEUROG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEUROG2 gene:
    Search GeneIP for patents involving NEUROG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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