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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEUROG1 Gene

protein-coding   GIFtS: 55
GCID: GC05M134897

Neurogenin 1


(Previous symbol: NEUROD3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurogenin 11 2     AKA2
NEUROD31 2 3 5     Math4C2
Neurogenic Differentiation 31 2     neurogenin-12
Class A Basic Helix-Loop-Helix Protein 62 3     ngn12
Neurogenic Basic-Helix-Loop-Helix Protein2 3     BHLHA63
Neurogenic Differentiation Factor 32 3     NGN3
NGN-12 3     NGN13
bHLHa62 3     NeuroD33

External Ids:    HGNC: 77641   Entrez Gene: 47622   Ensembl: ENSG000001819657   OMIM: 6017265   UniProtKB: Q928863   

Export aliases for NEUROG1 gene to outside databases

Previous GC identifers: GC05M134706 GC05M135581 GC05M134900 GC05M134946 GC05M130057


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NEUROG1 Gene: 
NEUROG1 (neurogenin 1) is a protein-coding gene. Diseases associated with NEUROG1 include cerebellar liponeurocytoma, and medulloblastoma. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NEUROG3.

UniProtKB/Swiss-Prot: NGN1_HUMAN, Q92886
Function: Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates
transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements
in genes encoding key transcriptional regulators of neurogenesis (By similarity)

Gene Wiki entry for NEUROG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEUROG1 gene promoter:
         TBP   Pax-2   USF-1:USF-2   Pax-2a   IRF-1   AREB6   FAC1   USF-1   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEUROG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23-q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

NEUROG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROG1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M134897:  view genomic region     (about GC identifiers)

Start:
134,869,972 bp from pter      End:
134,871,639 bp from pter
Size:
1,668 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NGN1_HUMAN, Q92886 (See protein sequence)
Recommended Name: Neurogenin-1  
Size: 237 amino acids; 25718 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5U0Q9 Q96HE1

Explore the universe of human proteins at neXtProt for NEUROG1: NX_Q92886

Explore proteomics data for NEUROG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92886

  • NEUROG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEUROG1 Protein Expression
    REFSEQ proteins: NP_006152.2  
    ENSEMBL proteins: 
     ENSP00000317580  

    Human Recombinant Protein Products for NEUROG1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for NEUROG1 
    OriGene Custom Protein Services for NEUROG1
    GenScript Custom Purified and Recombinant Proteins Services for NEUROG1
    Novus Biologicals NEUROG1 Protein
    Novus Biologicals NEUROG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEUROG1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0043025neuronal cell body ----
    GO:0043204perikaryon IEA--

    NEUROG1 for ontologies           About GeneDecksing



    NEUROG1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROG1
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    Novus Biologicals NEUROG1 Antibodies
    Abcam antibodies for NEUROG1
    Cloud-Clone Corp. Antibodies for NEUROG1 
    ThermoFisher Antibodies for NEUROG1
    LSBio Antibodies in human, mouse, rat for NEUROG1 

    Assay Products for NEUROG1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NEUROG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEUROG1 
    Cloud-Clone Corp. CLIAs for NEUROG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q92886

    ProtoNet protein and cluster: Q92886

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NGN1_HUMAN, Q92886
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    NEUROG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NGN1_HUMAN, Q92886
    Function: Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates
    transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements
    in genes encoding key transcriptional regulators of neurogenesis (By similarity)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000989transcription factor binding transcription factor activity ISS--
    GO:0003677DNA binding ISS--
    GO:0003682chromatin binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8816493
    GO:0005515protein binding ----
         
    NEUROG1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Neurog1):
     behavior/neurological  cellular  mortality/aging  nervous system  no phenotypic analysis 

    NEUROG1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEUROG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEUROG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEUROG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEUROG1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROG1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROG1 (see all 23):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-17 hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEUROG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEUROG1
    Sirion Biotech Customized adenovirus for overexpression of NEUROG1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NEUROG1 (see all 6)
    OriGene ORF clones in mouse, rat for NEUROG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROG1 (NM_006161)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG1
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                         Customized lentivirus expression plasmids for stable overexpression of NEUROG1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NEUROG1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEUROG1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2Selected targets of Oct-3/4
    Selected targets of Oct-3/4
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    4Neural Crest Differentiation
    Neural Crest Differentiation
    5Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for NEUROG1
        Selected targets of Oct-3/4
    Transcription factors in neurogenesis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NEUROG1
        Transcriptional Regulatory Network in Embryonic Stem Cell

    2 BioSystems Pathways for NEUROG1
        Neural Crest Differentiation
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription



    NEUROG1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEUROG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for NEUROG1 (Q928863 ENSP000003175804) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    SMAD1Q157973, ENSP000003057694I2D: score=2 STRING: ENSP00000305769
    RUNX1T1Q064553, ENSP000002658144I2D: score=2 STRING: ENSP00000265814
    CBFA2T2O434393, ENSP000002626534I2D: score=1 STRING: ENSP00000262653
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8816493
    GO:0007399nervous system development TAS8816493
    GO:0022008neurogenesis ----
    GO:0030182neuron differentiation IEA--

    NEUROG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEUROG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEUROG1 (NGN1)

    3 Novoseek inferred chemical compound relationships for NEUROG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 29.7 9 15206818 (4), 16699497 (1), 17270239 (1)
    calcium 0 4 16699497 (1), 17270239 (1)
    dopamine 0 2 16723737 (1), 14508844 (1)

    Search CenterWatch for drugs/clinical trials and news about NEUROG1 / NGN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEUROG1 gene: 
    NM_006161.2  

    Unigene Cluster for NEUROG1:

    Neurogenin 1
    Hs.248149  [show with all ESTs]
    Unigene Representative Sequence: NM_006161
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314744(uc003lax.3)
    miRNA
    Products:
         
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROG1 (see all 23):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-17 hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidNEUROG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG1
    Sirion Biotech Customized lentivirus for stable overexpression of NEUROG1 
                         Customized lentivirus expression plasmids for stable overexpression of NEUROG1 
    Primer
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    OriGene qPCR primer pairs and template standards for NEUROG1
    OriGene qSTAR qPCR primer pairs in human, mouse for NEUROG1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG1

    Additional mRNA sequence: 

    AB593107.1 AK314280.1 BC008687.1 BC028226.1 BT019366.1 

    1 DOTS entry:

    DT.91985139 

    7 AceView cDNA sequences:

    BX281027 BI915394 BC008687 BC028226 NM_006161 BE780690 AA074359 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEUROG1 expression in normal human tissues (normalized intensities)      NEUROG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEUROG1 Expression
    About this image


    NEUROG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             d6 Neural Progenitor Cells dP6 Neural Domain
             Telencephalon
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Sensory Ganglia Of Cranial Nerves Branchial Arch 2
             Frontonasal Process

    See NEUROG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEUROG1

    SOURCE GeneReport for Unigene cluster: Hs.248149

    UniProtKB/Swiss-Prot: NGN1_HUMAN, Q92886
    Tissue specificity: Expression restricted to the embryonic nervous system

        SABiosciences Expression via Pathway-Focused PCR Array including NEUROG1: 
              Neurogenesis in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEUROG1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurog11 , 5 neurogenin 11, 5 84.95(n)1
    90.3(a)1
      13 (30.06 cM)5
    180141  NM_010896.21  NP_035026.11 
     562505055 
    chicken
    (Gallus gallus)
    Aves NEUROG11 neurogenin 1 72.55(n)
    72.55(a)
      395699  NM_204883.1  NP_990214.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEUROG16
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343223.1(1068761-1069447)
    zebrafish
    (Danio rerio)
    Actinopterygii neurog12 neurogenin 1 78.43(n)   30239  AF036149.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tap6
    target of Poxn
    16(a)
    1 → many
    3L(17352782-17354911)
    worm
    (Caenorhabditis elegans)
    Secernentea ngn-16
    cnd-16
    Neurogenic differentiation factor 1
    25(a)
    24(a)
    many → 1
    possible ortholog
    IV(2626132-2628230)
    III(5240593-5242108)


    ENSEMBL Gene Tree for NEUROG1 (if available)
    TreeFam Gene Tree for NEUROG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEUROG1 gene
    NEUROG32  NEUROD22  NEUROG22  NEUROD12  NEUROD62  ATOH12  BHLHA152  ATOH72  
    NEUROD42  
    2 SIMAP similar genes for NEUROG1 using alignment to 2 protein entries:     NGN1_HUMAN (see all proteins):
    NEUROG3    NEUROG2

    NEUROG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/91 SNPs in NEUROG1 are shown (see all 91)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476605801,2
    C--134869510(+) GTTATA/GAGAGT 1 -- int10--------
    rs1407313351,2
    --134869684(+) AGCTGC/TGGATC 1 -- int10--------
    rs68956041,2
    C,F,H--134869976(+) CTTATT/ATTTAG 1 -- ut318Minor allele frequency- A:0.06NS EA WA CSA 604
    rs1922603511,2
    --134870109(+) TACTCC/TCCAGC 1 -- ut310--------
    rs1827712241,2
    --134870275(+) GCTCGC/TTTTTC 1 -- ut310--------
    rs1852394481,2
    --134870473(+) GCTGAA/GGGCCG 1 -- ut310--------
    rs119604421,2
    C,H--134870640(+) GGAGGG/AGGAAA 1 -- ut315Minor allele frequency- A:0.00NS EA 594
    rs2009615981,2
    --134870642(+) AGGGGA/GAAAGT 1 -- ut310--------
    rs1997103811,2
    --134870657(+) GTGTCG/TACAAA 1 -- ut310--------
    rs617375161,2
    C,F--134870722(+) GGCTTG/AGGAAG 2 /P /L mis12Minor allele frequency- A:0.00NS NA 4586

    HapMap Linkage Disequilibrium report for NEUROG1 (134869972 - 134871639 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NEUROG1: --

    Human Gene Mutation Database (HGMD): NEUROG1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601726    OMIM disorders: --

    9 diseases for NEUROG1:    About MalaCards
    cerebellar liponeurocytoma    medulloblastoma    primitive neuroectodermal tumor    neuroblastoma
    schizophrenia    retinitis    colorectal cancer    adenocarcinoma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NEUROG1:
    Colorectal cancer

    NEUROG1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for NEUROG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    medulloblastoma 34.1 8 17522332 (5)
    inflammation 0 1 11390944 (1)
    tumors 0 3 16699497 (1), 9270024 (1)
    carcinoma 0 6 16699497 (1)

    Genetic Association Database (GAD): NEUROG1
    Human Genome Epidemiology (HuGE) Navigator: NEUROG1 (9 documents)

    Export disorders for NEUROG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEUROG1 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with NEUROG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: Effects on illness susceptibility, MRI brain morphometry and cognitive abilities. (PubMed id 18799289)1, 4 Ho B.C....Wassink T.H. (2008)
    2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    3. Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis. (PubMed id 18053270)1, 4 Philippi A....Hager J. (2007)
    4. Association between the 5q31.1 gene neurogenin1 and schizophrenia. (PubMed id 17044100)1, 4 Fanous A.H....Kendler K.S. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. (PubMed id 9119405)1, 3 Tamimi R.M....Tapscott S.J. (1997)
    7. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. (PubMed id 8816493)1, 2 McCormick M.B....Tapscott S.J. (1996)
    8. Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells. (PubMed id 12526089)1, 9 Kim S....Suh-Kim H. (2002)
    9. Stable expression of neurogenin 1 induces LGR5, a nov el stem cell marker, in an immortalized human neural stem cell line HB1.F3. (PubMed id 19813087)1, 9 Satoh J....Kim S.U. (2010)
    10. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a 'fuzzy' com plex upon DNA binding. (PubMed id 20102160)1, 9 Aguado-Llera D....Neira J.L. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4762 HGNC: 7764 AceView: NEUROG1 Ensembl:ENSG00000181965 euGenes: HUgn4762
    ECgene: NEUROG1 H-InvDB: NEUROG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEUROG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEUROG1 gene:
    Search GeneIP for patents involving NEUROG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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