Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEUROG1 Gene

Aliases for NEUROG1 Gene

  • Neurogenin 1 2 3
  • NEUROD3 3 4 6
  • Neurogenic Basic-Helix-Loop-Helix Protein 3 4
  • Class A Basic Helix-Loop-Helix Protein 6 3 4
  • Neurogenic Differentiation Factor 3 3 4
  • Neurogenic Differentiation 3 2 3
  • BHLHa6 3 4
  • NGN-1 3 4
  • Ngn1 3 4
  • Neurogenin-1 3
  • Math4C 3
  • AKA 3
  • NGN 4

External Ids for NEUROG1 Gene

Previous HGNC Symbols for NEUROG1 Gene

  • NEUROD3

Previous GeneCards Identifiers for NEUROG1 Gene

  • GC05M134706
  • GC05M134900
  • GC05M134946
  • GC05M134897
  • GC05M130057

Summaries for NEUROG1 Gene

GeneCards Summary for NEUROG1 Gene

NEUROG1 (Neurogenin 1) is a Protein Coding gene. Diseases associated with NEUROG1 include moebius syndrome and medulloblastoma. Among its related pathways are Neural Crest Differentiation and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is BHLHA15.

UniProtKB/Swiss-Prot for NEUROG1 Gene

  • Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Gene Wiki entry for NEUROG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROG1 Gene

Genomics for NEUROG1 Gene

Regulatory Elements for NEUROG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NEUROG1 Gene

Start:
135,534,282 bp from pter
End:
135,535,949 bp from pter
Size:
1,668 bases
Orientation:
Minus strand

Genomic View for NEUROG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEUROG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROG1 Gene

Proteins for NEUROG1 Gene

  • Protein details for NEUROG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92886-NGN1_HUMAN
    Recommended name:
    Neurogenin-1
    Protein Accession:
    Q92886
    Secondary Accessions:
    • Q5U0Q9
    • Q96HE1

    Protein attributes for NEUROG1 Gene

    Size:
    237 amino acids
    Molecular mass:
    25718 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein

neXtProt entry for NEUROG1 Gene

Proteomics data for NEUROG1 Gene at MOPED

Post-translational modifications for NEUROG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NEUROG1 (Neurogenin-1)

No data available for DME Specific Peptides for NEUROG1 Gene

Domains for NEUROG1 Gene

Gene Families for NEUROG1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for NEUROG1 Gene

Suggested Antigen Peptide Sequences for NEUROG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92886

UniProtKB/Swiss-Prot:

NGN1_HUMAN :
  • Q92886
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NEUROG1: view

Function for NEUROG1 Gene

Molecular function for NEUROG1 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000989 transcription factor binding transcription factor activity ISS --
GO:0003677 DNA binding ISS --
GO:0003682 chromatin binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8816493
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NEUROG1: view
genes like me logo Genes that share phenotypes with NEUROG1: view

Animal Model Products

miRNA for NEUROG1 Gene

miRTarBase miRNAs that target NEUROG1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NEUROG1 Gene

Localization for NEUROG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROG1 Gene COMPARTMENTS Subcellular localization image for NEUROG1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043025 neuronal cell body --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with NEUROG1: view

Pathways for NEUROG1 Gene

genes like me logo Genes that share pathways with NEUROG1: view

Pathways by source for NEUROG1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8816493
GO:0007399 nervous system development TAS 8816493
GO:0022008 neurogenesis --
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with NEUROG1: view

Compounds for NEUROG1 Gene

(3) Novoseek inferred chemical compound relationships for NEUROG1 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 29.7 6
calcium 0 2
dopamine 0 2
genes like me logo Genes that share compounds with NEUROG1: view

Transcripts for NEUROG1 Gene

mRNA/cDNA for NEUROG1 Gene

(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROG1 Gene

Neurogenin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEUROG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG1 Gene

No ASD Table

Relevant External Links for NEUROG1 Gene

GeneLoc Exon Structure for
NEUROG1
ECgene alternative splicing isoforms for
NEUROG1

Expression for NEUROG1 Gene

mRNA expression in normal human tissues for NEUROG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROG1 Gene

This gene is overexpressed in Testis (18.4) and Ovary (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEUROG1 Gene

SOURCE GeneReport for Unigene cluster for NEUROG1 Gene Hs.248149

mRNA Expression by UniProt/SwissProt for NEUROG1 Gene

Q92886-NGN1_HUMAN
Tissue specificity: Expression restricted to the embryonic nervous system
genes like me logo Genes that share expressions with NEUROG1: view

In Situ Assay Products

Orthologs for NEUROG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROG1 35
  • 99.44 (n)
  • 99.16 (a)
NEUROG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEUROG1 35
  • 86.36 (n)
  • 87.34 (a)
NEUROG1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROG1 35
  • 86.36 (n)
  • 86.92 (a)
NEUROG1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurog1 35
  • 84.95 (n)
  • 90.3 (a)
Neurog1 16
Neurog1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEUROG1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROG1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurog1 35
  • 85.09 (n)
  • 90.3 (a)
chicken
(Gallus gallus)
Aves NEUROG1 35
  • 72.55 (n)
  • 72.55 (a)
lizard
(Anolis carolinensis)
Reptilia NEUROG1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurog1 35
  • 55.45 (n)
  • 52.97 (a)
zebrafish
(Danio rerio)
Actinopterygii neurog1 35
  • 62.5 (n)
  • 61.76 (a)
neurog1 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tap 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for NEUROG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEUROG1 Gene

ENSEMBL:
Gene Tree for NEUROG1 (if available)
TreeFam:
Gene Tree for NEUROG1 (if available)

Paralogs for NEUROG1 Gene

Selected SIMAP similar genes for NEUROG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEUROG1: view

Variants for NEUROG1 Gene

Sequence variations from dbSNP and Humsavar for NEUROG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs123121 -- 135,536,917(+) TTCTT(C/T)GGCGT upstream-variant-2KB
rs740661 -- 135,536,665(+) GCTGA(C/T)GAAGA upstream-variant-2KB
rs758459 -- 135,537,014(+) CAGGG(C/T)GAGCC upstream-variant-2KB
rs4976309 -- 135,536,008(+) ACAAT(A/G/T)GGCGC upstream-variant-2KB
rs6895604 -- 135,534,286(+) CTTAT(A/T)TTTAG utr-variant-3-prime

Relevant External Links for NEUROG1 Gene

HapMap Linkage Disequilibrium report
NEUROG1
Human Gene Mutation Database (HGMD)
NEUROG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEUROG1 Gene

Disorders for NEUROG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NEUROG1 Gene including...

Search for NEUROG1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NEUROG1 Gene

(4) Novoseek inferred disease relationships for NEUROG1 Gene

Disease -log(P) Hits PubMed IDs
medulloblastoma 34.1 5
inflammation 0 1
tumors 0 2
carcinoma 0 1

Relevant External Links for NEUROG1

Genetic Association Database (GAD)
NEUROG1
Human Genome Epidemiology (HuGE) Navigator
NEUROG1
genes like me logo Genes that share disorders with NEUROG1: view

No data available for UniProtKB/Swiss-Prot for NEUROG1 Gene

Publications for NEUROG1 Gene

  1. Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells. (PMID: 12526089) Kim S. … Suh-Kim H. (Exp. Mol. Med. 2002) 3 23
  2. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. (PMID: 11239394) Sun Y. … Greenberg M.E. (Cell 2001) 3 23
  3. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. (PMID: 20102160) Aguado-Llera D. … Neira J.L. (Biochemistry 2010) 3 23
  4. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. (PMID: 8816493) McCormick M.B. … Tapscott S.J. (Mol. Cell. Biol. 1996) 3 4
  5. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. (PMID: 9119405) Tamimi R.M. … Tapscott S.J. (Genomics 1997) 2 3

Products for NEUROG1 Gene

Sources for NEUROG1 Gene

Back to Top

Content