NEUROG1 Gene

Aliases
for NEUROG1 gene

Previous GC identifers: GC05M134706 GC05M135581 GC05M134900 GC05M134946 GC05M130057

Summaries
for NEUROG1 gene

Genomic Views
for NEUROG1 gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_034772.6  

SwitchGear Promoter luciferase reporter plasmid: NEUROG1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROG1

NEUROG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M134897:  view genomic region     (about GC identifiers)

Proteins
for NEUROG1 gene

Explore the universe of human proteins at neXtProt for NEUROG1: NX_Q92886

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NEUROG1 OriGene Protein Over-expression Lysate: NEUROG1 OriGene Custom Protein Services for NEUROG1
	GenScript Custom Purified and Recombinant Proteins Services for NEUROG1
	Novus Biologicals NEUROG1 Protein Novus Biologicals NEUROG1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NEUROG1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROG1
	R&D Systems Antibodies for NEUROG1 (Neurogenin-1)
	OriGene Antibodies (see all 15): NEUROG1 OriGene Custom Antibody Services for NEUROG1
	GenScript Custom Superior Antibodies Services for NEUROG1
	Novus Biologicals NEUROG1 Antibodies
	Search for Antibodies for NEUROG1 at Abcam
	Uscn Antibodies for NEUROG1
	ThermoFisher Antibodies for NEUROG1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NEUROG1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NEUROG1

Protein Domains /
Families
for NEUROG1 gene

ProtoNet protein and cluster: Q92886

Function
for NEUROG1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROG1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROG1 (see all 23):
		hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-17 hsa-miR-130b hsa-miR-301b
		SwitchGear 3'UTR luciferase reporter plasmid: NEUROG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROG1 (see all 7) OriGene shRNA RFP: NEUROG1 OriGene siRNA: NEUROG1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROG1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NEUROG1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROG1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NEUROG1 (NM_006161)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROG1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROG1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NEUROG1
		Search LifeMap BioReagents cell lines for NEUROG1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 2 alleles) (MGI details for Neurog1)

Pathways & Interactions
for NEUROG1 gene

	Super-pathway	contained gene-specific pathways
1	Transcription factors in neurogenesis	Transcription factors in neurogenesis 1.00
2	Selected targets of Oct-3/4	Selected targets of Oct-3/4 1.00
3	Neural Crest Differentiation	Neural Crest Differentiation 1.00
4	Regulation of Wnt-mediated beta catenin signaling and target gene transcription	Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1.00
5	Transcriptional Regulatory Network in Embryonic Stem Cell	Transcriptional Regulatory Network in Embryonic Stem Cell 1.00

2 EMD Millipore Pathways for NEUROG1

	Selected targets of Oct-3/4
	Transcription factors in neurogenesis

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NEUROG1

Transcriptional Regulatory Network in Embryonic Stem Cell

2 BioSystems Pathways for NEUROG1

	Neural Crest Differentiation
	Regulation of Wnt-mediated beta catenin signaling and target gene transcription

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

Drugs & Compounds
for NEUROG1 gene

Transcripts
for NEUROG1 gene

Expression
for NEUROG1 gene

NEUROG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Head MesenchymeBranchial Arch 1Sensory Ganglia Of Cranial Nerves			Neural Crest
	Head MesenchymeBranchial Arch 2Sensory Ganglia Of Cranial Nerves			Neural Crest
	Head MesenchymeBranchial Arch 3,4,6Sensory Ganglia Of Cranial Nerves			Neural Crest
	Head MesenchymePrechordal MesenchymeSensory Ganglia Of Cranial Nerves			Neural Crest
	Neural CrestTrunk Neural CrestDorsal Root Ganglia			Neural Crest
	BoneMaxillary Process			Bone
	BrainHypothalamus			Brain
	BrainThalamus			Brain
	Head MesenchymeFrontonasal Process			Head Mesenchyme
	Neural TubeDiencephalic Ventricular Zone			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Skeletal myocytes (Generation of skelet...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROG1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEUROG1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROG1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROG1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROG1

Orthologs
for NEUROG1 gene

Paralogs
for NEUROG1 gene

Paralogs for NEUROG1 gene

NEUROG3²  FERD3L²  NEUROD2²  NEUROD1²  NEUROD6²  NEUROG2²  ATOH1²  BHLHA15²  

PTF1A²  ATOH7²  NEUROD4²  

2 SIMAP similar genes for NEUROG1 using alignment to 2 protein entries:     NGN1_HUMAN (see all proteins):

NEUROG3    NEUROG2

NEUROG1 for paralogs           About GeneDecksing

Genomic Variants
for NEUROG1 gene

10/70 NCBI SNPs in NEUROG1 are shown (see all 70)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1476605801,2		--	134869510(+)	GTTATA/GAGAGT	1	--	int1		0	--	--	--	--
rs1407313351,2		--	134869684(+)	AGCTGC/TGGATC	1	--	int1		0	--	--	--	--
rs68956041,2	C,F,H,	--	134869976(+)	CTTATT/ATTTAG	1	--	ut31		8		NS EA WA CSA	604
rs1922603511,2		--	134870109(+)	TACTCC/TCCAGC	1	--	ut31		0	--	--	--	--
rs1827712241,2		--	134870275(+)	GCTCGC/TTTTTC	1	--	ut31		0	--	--	--	--
rs1852394481,2		--	134870473(+)	GCTGAA/GGGCCG	1	--	ut31		0	--	--	--	--
rs119604421,2	C,H,	--	134870640(+)	GGAGGG/AGGAAA	1	--	ut31		5		NS EA	594
rs2009615981,2		--	134870642(+)	AGGGGA/GAAAGT	1	--	ut31		0	--	--	--	--
rs1997103811,2		--	134870657(+)	GTGTCG/TACAAA	1	--	ut31		0	--	--	--	--
rs617375161,2	C,F	--	134870722(+)	GGCTTG/AGGAAG	2	/P /L	mis1		2		NS NA	4586

HapMap Linkage Disequilibrium report for NEUROG1 (134869972 - 134871639 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NEUROG1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEUROG1

DNA2.0 Custom Variant and Variant Library Synthesis for NEUROG1

Disorders / Diseases
for NEUROG1 gene

12 diseases for NEUROG1

4 Novoseek disease relationships for NEUROG1 gene    About this table

Publications
for NEUROG1 gene

PubMed articles for NEUROG1 gene, integrated from 9 sources (see all 62): (articles sorted by number of sources associating them with NEUROG1)

Utopia: connect your pdf to the dynamic world of online information

1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
2. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. (PubMed id 9119405)^{1, 3} Tamimi R.M....Tapscott S.J. (1997)
3. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. (PubMed id 8816493)^{1, 2} McCormick M.B....Tapscott S.J. (1996)
4. Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells. (PubMed id 12526089)^{1, 9} Kim S....Suh-Kim H. (2002)
5. Stable expression of neurogenin 1 induces LGR5, a nov el stem cell marker, in an immortalized human neural stem cell line HB1.F3. (PubMed id 19813087)^{1, 9} Satoh J....Kim S.U. (2010)
6. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a 'fuzzy' com plex upon DNA binding. (PubMed id 20102160)^{1, 9} Aguado-Llera D....Neira J.L. (2010)
7. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. (PubMed id 11239394)^{1, 9} Sun Y....Greenberg M.E. (2001)
8. Methylation of NEUROG1 in serum is a sensitive marker for the detection of early colorectal cancer. (PubMed id 21326223)¹ Herbst A....Kolligs F.T. (2011)
9. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)¹ Oshikawa M.... Kato S. (2011)
10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)

External Searches for NEUROG1 gene

Genome Databases showing NEUROG1 gene

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Products
for NEUROG1 gene