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Aliases for NEUROG1 Gene

Aliases for NEUROG1 Gene

  • Neurogenin 1 2 3 5
  • Neurogenic Basic-Helix-Loop-Helix Protein 3 4
  • Class A Basic Helix-Loop-Helix Protein 6 3 4
  • Neurogenic Differentiation Factor 3 3 4
  • Neurogenic Differentiation 3 2 3
  • NEUROD3 3 4
  • BHLHa6 3 4
  • NGN-1 3 4
  • Ngn1 3 4
  • Math4C 3
  • NGN 4
  • AKA 3

External Ids for NEUROG1 Gene

Previous HGNC Symbols for NEUROG1 Gene

  • NEUROD3

Previous GeneCards Identifiers for NEUROG1 Gene

  • GC05M134706
  • GC05M134900
  • GC05M134946
  • GC05M134897
  • GC05M130057

Summaries for NEUROG1 Gene

GeneCards Summary for NEUROG1 Gene

NEUROG1 (Neurogenin 1) is a Protein Coding gene. Diseases associated with NEUROG1 include Cerebellar Liponeurocytoma and Moebius Syndrome. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is BHLHA15.

UniProtKB/Swiss-Prot for NEUROG1 Gene

  • Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Gene Wiki entry for NEUROG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROG1 Gene

Genomics for NEUROG1 Gene

Regulatory Elements for NEUROG1 Gene

Enhancers for NEUROG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NEUROG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEUROG1 Gene

Chromosome:
5
Start:
135,534,282 bp from pter
End:
135,535,949 bp from pter
Size:
1,668 bases
Orientation:
Minus strand

Genomic View for NEUROG1 Gene

Genes around NEUROG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROG1 Gene

Proteins for NEUROG1 Gene

  • Protein details for NEUROG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92886-NGN1_HUMAN
    Recommended name:
    Neurogenin-1
    Protein Accession:
    Q92886
    Secondary Accessions:
    • Q5U0Q9
    • Q96HE1

    Protein attributes for NEUROG1 Gene

    Size:
    237 amino acids
    Molecular mass:
    25718 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROG1 Gene

Proteomics data for NEUROG1 Gene at MOPED

Post-translational modifications for NEUROG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEUROG1 Gene

Domains & Families for NEUROG1 Gene

Gene Families for NEUROG1 Gene

Protein Domains for NEUROG1 Gene

Suggested Antigen Peptide Sequences for NEUROG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92886

UniProtKB/Swiss-Prot:

NGN1_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NEUROG1: view

Function for NEUROG1 Gene

Molecular function for NEUROG1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8816493
GO:0005515 protein binding IEA,IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NEUROG1: view
genes like me logo Genes that share phenotypes with NEUROG1: view

Animal Models for NEUROG1 Gene

MGI Knock Outs for NEUROG1:

Animal Model Products

miRNA for NEUROG1 Gene

miRTarBase miRNAs that target NEUROG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROG1 Gene

Localization for NEUROG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROG1 Gene COMPARTMENTS Subcellular localization image for NEUROG1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for NEUROG1 Gene

Pathways & Interactions for NEUROG1 Gene

genes like me logo Genes that share pathways with NEUROG1: view

Gene Ontology (GO) - Biological Process for NEUROG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022008 neurogenesis IEA --
GO:0030182 neuron differentiation IEA --
GO:0031536 positive regulation of exit from mitosis IEA --
GO:0042472 inner ear morphogenesis IEA --
GO:0045165 cell fate commitment IEA --
genes like me logo Genes that share ontologies with NEUROG1: view

No data available for SIGNOR curated interactions for NEUROG1 Gene

Drugs & Compounds for NEUROG1 Gene

(2) Drugs for NEUROG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NEUROG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEUROG1: view

Transcripts for NEUROG1 Gene

mRNA/cDNA for NEUROG1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROG1 Gene

Neurogenin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROG1 Gene

No ASD Table

Relevant External Links for NEUROG1 Gene

GeneLoc Exon Structure for
NEUROG1
ECgene alternative splicing isoforms for
NEUROG1

Expression for NEUROG1 Gene

mRNA expression in normal human tissues for NEUROG1 Gene

mRNA differential expression in normal tissues according to GTEx for NEUROG1 Gene

This gene is overexpressed in Testis (x18.4) and Ovary (x5.7).

Protein differential expression in normal tissues from HIPED for NEUROG1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEUROG1 Gene



SOURCE GeneReport for Unigene cluster for NEUROG1 Gene Hs.248149

mRNA Expression by UniProt/SwissProt for NEUROG1 Gene

Q92886-NGN1_HUMAN
Tissue specificity: Expression restricted to the embryonic nervous system.
genes like me logo Genes that share expression patterns with NEUROG1: view

Protein tissue co-expression partners for NEUROG1 Gene

Primer Products

Orthologs for NEUROG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEUROG1 35
  • 86.36 (n)
  • 87.34 (a)
NEUROG1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROG1 35
  • 86.36 (n)
  • 86.92 (a)
NEUROG1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurog1 35
  • 84.95 (n)
  • 90.3 (a)
Neurog1 16
Neurog1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEUROG1 35
  • 99.44 (n)
  • 99.16 (a)
NEUROG1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurog1 35
  • 85.09 (n)
  • 90.3 (a)
oppossum
(Monodelphis domestica)
Mammalia NEUROG1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROG1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEUROG1 35
  • 72.55 (n)
  • 72.55 (a)
lizard
(Anolis carolinensis)
Reptilia NEUROG1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurog1 35
  • 55.45 (n)
  • 52.97 (a)
zebrafish
(Danio rerio)
Actinopterygii neurog1 35
  • 62.5 (n)
  • 61.76 (a)
neurog1 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tap 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for NEUROG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEUROG1 Gene

ENSEMBL:
Gene Tree for NEUROG1 (if available)
TreeFam:
Gene Tree for NEUROG1 (if available)

Paralogs for NEUROG1 Gene

(2) SIMAP similar genes for NEUROG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEUROG1: view

Variants for NEUROG1 Gene

Sequence variations from dbSNP and Humsavar for NEUROG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs740661 -- 135,536,665(+) GCTGA(C/T)GAAGA upstream-variant-2KB
rs758459 -- 135,537,014(+) CAGGG(C/T)GAGCC upstream-variant-2KB
rs123121 -- 135,536,917(+) TTCTT(C/T)GGCGT upstream-variant-2KB
rs6895604 -- 135,534,286(+) CTTAT(A/T)TTTAG utr-variant-3-prime
rs34137563 -- 135,535,590(-) TGCCA(A/G)ACTCC reference, missense

Variation tolerance for NEUROG1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEUROG1 Gene

Human Gene Mutation Database (HGMD)
NEUROG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEUROG1 Gene

Disorders for NEUROG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NEUROG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebellar liponeurocytoma
  • central neurocytoma
moebius syndrome
  • mobius syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NEUROG1

Genetic Association Database (GAD)
NEUROG1
Human Genome Epidemiology (HuGE) Navigator
NEUROG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEUROG1
genes like me logo Genes that share disorders with NEUROG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEUROG1 Gene

Publications for NEUROG1 Gene

  1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48 67
  2. Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3. (PMID: 19813087) Satoh J. … Kim S.U. (Cell. Mol. Neurobiol. 2010) 3 23
  3. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. (PMID: 20102160) Aguado-Llera D. … Neira J.L. (Biochemistry 2010) 3 23
  4. Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells. (PMID: 12526089) Kim S. … Suh-Kim H. (Exp. Mol. Med. 2002) 3 23
  5. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. (PMID: 11239394) Sun Y. … Greenberg M.E. (Cell 2001) 3 23

Products for NEUROG1 Gene

Sources for NEUROG1 Gene

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